Page last updated: 2024-09-04

febuxostat and cyclosporine

febuxostat has been researched along with cyclosporine in 4 studies

Compound Research Comparison

Studies (febuxostat)	Trials (febuxostat)	Recent Studies (post-2010) (febuxostat)	Studies (cyclosporine)	Trials (cyclosporine)	Recent Studies (post-2010) (cyclosporine)
818	133	710	377	2	170

Protein Interaction Comparison

Protein	Taxonomy	cyclosporine (IC50)
ATP-binding cassette sub-family C member 3	Homo sapiens (human)	0.6315
Bile salt export pump	Rattus norvegicus (Norway rat)	0.6
Bile salt export pump	Homo sapiens (human)	3.5
Interleukin-2	Mus musculus (house mouse)	0.005
ATP-dependent translocase ABCB1	Mus musculus (house mouse)	0.7
ATP-dependent translocase ABCB1	Homo sapiens (human)	1.6792
Cytochrome P450 3A4	Homo sapiens (human)	3.734
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	5.82
Alpha-1B adrenergic receptor	Rattus norvegicus (Norway rat)	9.34
Cytochrome P450 3A5	Homo sapiens (human)	2.06
ATP-dependent translocase ABCB1	Mus musculus (house mouse)	4.8
Substance-K receptor	Homo sapiens (human)	4.139
Peptidyl-prolyl cis-trans isomerase B	Homo sapiens (human)	0.0088
Alpha-1D adrenergic receptor	Rattus norvegicus (Norway rat)	9.34
Cytochrome P450 3A7	Homo sapiens (human)	2.06
Cytochrome P450 2C19	Homo sapiens (human)	7
Multidrug resistance-associated protein 1	Homo sapiens (human)	3.5082
Alpha-1A adrenergic receptor	Rattus norvegicus (Norway rat)	9.34
Peptidyl-prolyl cis-trans isomerase A	Homo sapiens (human)	0.0252
Peptidyl-prolyl cis-trans isomerase FKBP4	Homo sapiens (human)	0.016
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	Homo sapiens (human)	0.183
Peptidyl-prolyl cis-trans isomerase D	Homo sapiens (human)	0.0036
Sodium/bile acid cotransporter	Homo sapiens (human)	1
Reverse transcriptase/RNaseH	Human immunodeficiency virus 1	0.455
Cytochrome P450 3A43	Homo sapiens (human)	2.06
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Mus musculus (house mouse)	0.57
Solute carrier organic anion transporter family member 1B3	Homo sapiens (human)	1.3
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)	4.3
Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)	0.95

Research

Studies (4)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	3 (75.00)	24.3611
2020's	1 (25.00)	2.80

Authors

Authors	Studies
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Delabio, LC; Dutra, JP; Hembecker, M; Kita, DH; Moure, VR; Pereira, GDS; Scheiffer, G; Valdameri, G; Zattoni, IF	1

Reviews

2 review(s) available for febuxostat and cyclosporine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Targeting breast cancer resistance protein (BCRP/ABCG2): Functional inhibitors and expression modulators. European journal of medicinal chemistry, 2022, Jul-05, Volume: 237 Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Breast Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Neoplasm Proteins; Neoplastic Stem Cells	2022

Other Studies

2 other study(ies) available for febuxostat and cyclosporine

Article	Year
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016

Article

Year

A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.

Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013

Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.

Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16

Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone

2016