Compounds > febrifugine

Page last updated: 2024-08-24

febrifugine and halofuginone

febrifugine has been researched along with halofuginone in 7 studies

Research

Studies (7)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (14.29)	29.6817
2010's	6 (85.71)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Samant, BS; Sukhthankar, MG	1
Evans, P; McLaughlin, NP	1
Cortese, JF; Dignam, JD; Edenius, M; Hendrick, M; Keller, TL; Kim, YJ; Lee, HK; Mazitschek, R; Rao, A; Sundrud, MS; Whitman, M; Wirth, DF; Yeo, CY; Yum, J; Zocco, D	1
Schimmel, P; Sun, L; Yang, XL; Zhou, H	1
Evans, P; McLaughlin, NP; Pines, M	1
Bopp, SE; Clardy, J; Clish, CB; Cortese, JF; Derbyshire, ER; Estiu, G; Galinsky, K; Herman, JD; Keller, TL; Lindquist, S; Lukens, AK; Mazitschek, R; Mota, MM; Patel, V; Pepper, LR; Ribacke, U; Santos, SA; Schimmel, P; Sullivan, WJ; Whitman, M; Wiest, O; Wirth, DF; Zhou, H; Zuzarte-Luis, V	1
Evans, P; McLaughlin, NP; Smullen, S	1

Reviews

2 review(s) available for febrifugine and halofuginone

Article	Year
The chemistry and biology of febrifugine and halofuginone. Bioorganic & medicinal chemistry, 2014, Apr-01, Volume: 22, Issue:7 Topics: Antimalarials; Humans; Molecular Structure; Parasitic Sensitivity Tests; Piperidines; Plasmodium; Quinazolines; Quinazolinones; Structure-Activity Relationship	2014
Chemical synthesis of febrifugine and analogues. Bioorganic & medicinal chemistry, 2018, 05-15, Volume: 26, Issue:9 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antimalarials; Cyclization; Cycloaddition Reaction; Humans; Piperidines; Plasmodium falciparum; Quinazolines; Quinazolinones; Stereoisomerism	2018

Other Studies

5 other study(ies) available for febrifugine and halofuginone

Article	Year
Synthesis and comparison of antimalarial activity of febrifugine derivatives including halofuginone. Medicinal chemistry (Shariqah (United Arab Emirates)), 2009, Volume: 5, Issue:3 Topics: Animals; Antimalarials; Benzoates; Cell Line; Piperidines; Plasmodium falciparum; Quinazolines; Quinazolinones	2009
Dihydroxylation of vinyl sulfones: stereoselective synthesis of (+)- and (-)-febrifugine and halofuginone. The Journal of organic chemistry, 2010, Jan-15, Volume: 75, Issue:2 Topics: Catalysis; Hydroxylation; Molecular Structure; Piperidines; Quinazolines; Quinazolinones; Stereoisomerism; Sulfones	2010
Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase. Nature chemical biology, 2012, Feb-12, Volume: 8, Issue:3 Topics: Amino Acyl-tRNA Synthetases; Animals; Cell Differentiation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Mice; Mice, Inbred C57BL; Piperidines; Quinazolines; Quinazolinones; Structure-Activity Relationship; Th17 Cells	2012
ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase. Nature, 2013, Feb-07, Volume: 494, Issue:7435 Topics: Adenosine Triphosphate; Amino Acyl-tRNA Synthetases; Antimalarials; Binding Sites; Crystallography, X-Ray; Herbal Medicine; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Ligands; Medicine, Chinese Traditional; Models, Molecular; Piperidines; Proline; Quinazolines; Quinazolinones; RNA, Transfer	2013
The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs. Science translational medicine, 2015, May-20, Volume: 7, Issue:288 Topics: Amino Acyl-tRNA Synthetases; Animals; Antimalarials; Computer-Aided Design; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Drug Resistance; Enzyme Inhibitors; Erythrocytes; Liver; Malaria, Falciparum; Mice; Models, Molecular; Molecular Structure; Molecular Targeted Therapy; Piperidines; Plasmodium falciparum; Protozoan Proteins; Quinazolines; Quinazolinones; Structure-Activity Relationship; Time Factors	2015