fd-891 has been researched along with 3-hydroxybutanal* in 1 studies
1 other study(ies) available for fd-891 and 3-hydroxybutanal
Article | Year |
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A concise and unified strategy for synthesis of the C1-C18 macrolactone fragments of FD-891, FD-892 and their analogues: formal total synthesis of FD-891.
A concise and unified strategy for the synthesis of C1-C18 macrolactone fragments of FD-891 and FD-892 as well as their analogues is reported. The strategy includes a stereoselective vinylogous Mukaiyama aldol reaction (VMAR) using chiral silyl ketene N,O-acetal to construct C6-C7 stereocenters, an E-selective ring closing metathesis to construct a C12-C13 olefin, and stereodivergent construction of a C8-C9 epoxide. Topics: Aldehydes; Lactones; Macrolides; Molecular Structure; Stereoisomerism | 2014 |