farnesyl-pyrophosphate has been researched along with tetronic-acid* in 1 studies
1 other study(ies) available for farnesyl-pyrophosphate and tetronic-acid
| Article | Year |
|---|---|
Design and structure-activity relationships of potent and selective inhibitors of undecaprenyl pyrophosphate synthase (UPPS): tetramic, tetronic acids and dihydropyridin-2-ones.
Based on a pharmacophore hypothesis substituted tetramic and tetronic acid 3-carboxamides as well as dihydropyridin-2-one-3-carboxamides were investigated as inhibitors of undecaprenyl pyrophosphate synthase (UPPS) for use as novel antimicrobial agents. Synthesis and structure-activity relationship patterns for this class of compounds are discussed. Selectivity data and antibacterial activities for selected compounds are provided. Topics: Alkyl and Aryl Transferases; Amides; Cyclization; Drug Design; Enzyme Inhibitors; Escherichia coli; Furans; Microbial Sensitivity Tests; Molecular Structure; Polyisoprenyl Phosphates; Protein Conformation; Pyrrolidinones; Sesquiterpenes; Streptococcus pneumoniae; Structure-Activity Relationship | 2008 |