farnesol has been researched along with mevalonic acid in 112 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 36 (32.14) | 18.7374 |
| 1990's | 46 (41.07) | 18.2507 |
| 2000's | 16 (14.29) | 29.6817 |
| 2010's | 14 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cornforth, J | 1 |
| Bhavnani, BR; Woolever, CA | 1 |
| Peter, MG; Schmid, H; Woggon, WD | 1 |
| Parker, TS; Popják, G; Sutherland, K; Wong, SM | 1 |
| Hanson, JR; Nyfeler, R | 1 |
| Edmond, J; Fogelman, AM; Popják, G; Seager, J | 1 |
| Bradfute, DL; Silva, CJ; Simoni, RD | 1 |
| Anant, JS; Fung, BK | 1 |
| Havel, CM; Watson, JA | 1 |
| Armstrong, J; Fawell, EH; Giannakouros, T; Hancock, JF; Magee, AI; Newman, CM | 1 |
| Djerassi, C; Silva, CJ; Wünsche, L | 1 |
| Fujiyama, A; Sakiyama, F; Tamanoi, F; Tsunasawa, S | 1 |
| Brown, MS; Goldstein, JL | 1 |
| Keung, WM | 1 |
| Bourne, JR; Buss, JE; Cochrane, CG; Der, CJ; Jackson, JH; Solski, PA | 1 |
| Cañada, FJ; Lai, RK; Perez-Sala, D; Rando, RR | 1 |
| Chambon, C; Karst, F; Ladeveze, V; Oulmouden, A; Servouse, M | 1 |
| Buss, JE; Casey, PJ; Der, CJ; Solski, PA | 1 |
| Erdman, RA; Maltese, WA | 1 |
| Arison, B; Gonzalez-Pacanowska, D; Havel, CM; Watson, JA | 1 |
| Farnsworth, DE; Feyereisen, R | 1 |
| Beedle, AS; Munday, KA; Wilton, DC | 3 |
| Carlson, JP; Kuehl, L; Muscio, F; Rilling, HC | 1 |
| Gosselin, L | 1 |
| Cornforth, JW; Cornforth, RH; Popják, G; Yengoyan, L | 1 |
| Dorsey, JK; Porter, JW | 1 |
| Fairbairn, D; Frayha, GJ | 1 |
| Heinstein, PF; Herman, DL; Smith, FH; Tove, SB | 1 |
| Gough, DP; Hemming, FW | 1 |
| Flint, AP | 1 |
| Popják, G | 2 |
| Beytia, E; Briedis, A; Craig, MC; Dugan, RE; Feldbruegge, DH; Porter, JW; Qureshi, AA; Slakey, LL; Subbarayan, C | 1 |
| Stone, KJ; Strominger, JL | 1 |
| Benveniste, P; Coates, RM; Heintz, R; Robinson, WH | 1 |
| Ness, GC; Porter, JW; Qureshi, N; Slakey, LL | 1 |
| Cohen, P; Derksen, A | 1 |
| Graebe, JE | 1 |
| Dahm, KH; Metzler, M; Meyer D Röller, H | 1 |
| Pennock, JF; Walton, MJ | 1 |
| Overton, KH; Roberts, FM | 1 |
| Hemming, FW; Richards, JB | 1 |
| Benveniste, P; Hirth, L; Ourisson, G | 1 |
| Bhavnani, BR | 1 |
| Bernini, F; Corsini, A; Fumagalli, R; Paoletti, R; Raiteri, M; Soma, MR | 1 |
| Meigs, TE; Sherwood, SW; Simoni, RD | 1 |
| Andres, DA; Crick, DC; Waechter, CJ | 2 |
| Betteridge, L; Chan, P; Clunn, G; Gallagher, K; Hughes, A; Munro, E; Patel, M; Schachter, M; Sever, P; Wolfe, J | 1 |
| Blazejewski, S; Dhumeaux, D; Mallat, A; Mavier, P; Preaux, AM; Rosenbaum, J | 1 |
| Correll, CC; Edwards, PA; Ng, L | 1 |
| Corsini, A; Fumagalli, R; Gabbiani, G; Mazzotti, M; Paoletti, R; Raiteri, M; Soma, MR | 1 |
| Foster, JM; Marshall, I; Pennock, JF; Rees, HH | 1 |
| Atluru, D; Kasiske, BL; Keane, WF; Kim, Y; O'Donnell, MP | 1 |
| Oi, S; Tachibana, A; Tanaka, T; Taniguchi, M | 1 |
| Andersson, B; Dallner, G; Parmryd, I; Shipton, CA; Swiezewska, E | 1 |
| Meigs, TE; Roseman, DS; Simoni, RD | 1 |
| Chambers, C; Keller, RK; Ness, GC; Zhao, Z | 1 |
| Nakata, H; Nishio, E; Tomiyama, K; Watanabe, Y | 1 |
| Favre, G; Miquel, K; Pradines, A | 1 |
| Ayukawa, K; Isobe, H; Nawata, H; Sakai, H; Satoh, T | 1 |
| Kanayama, Y; Negoro, N; Okamura, M; Takeda, T; Umetani, N | 1 |
| Hamilton, AD; McGuire, TF; Qian, Y; Sebti, SM; Vogt, A | 1 |
| Brown, BE; Denda, M; Elias, PM; Feingold, KR | 1 |
| Durham, SK; Flint, OP; Gregg, RE; Masters, BA | 1 |
| Meigs, TE; Simoni, RD | 1 |
| Andres, DA; Crick, DC; Finlin, BS; Shao, H | 1 |
| Bitterman, P; Greatens, T; Kratzke, RA; Polunovsky, VA; Rubins, JB; Tan, AT | 1 |
| Andres, DA; Crick, DC; Danesi, R; Macchia, M; Waechter, CJ | 1 |
| Bansal, VS; Bergstrom, JD; Bostedor, R; Kurtz, MM; Vaidya, S | 1 |
| Kanda, Y; Nishio, E; Watanabe, Y | 1 |
| Aboushadi, N; Krisans, SK | 1 |
| Croucher, PI; Helfrich, MH; Rogers, MJ; Russell, RG; Shipman, CM | 1 |
| Fisher, JE; Halasy, JM; Hughes, DE; Luckman, SP; Masarachia, PJ; Reszka, AA; Rodan, GA; Rogers, MJ; Russell, RG; Wesolowski, G | 1 |
| Dallner, G; Parmryd, I | 1 |
| Aloj, SM; Bifulco, M; Laezza, C | 1 |
| Foster, BA; Ghosh, PM; Ghosh-Choudhury, N; Greenberg, NM; Kreisberg, JI; Mott, GE; Moyer, ML; Thomas, CA | 1 |
| Andersson, B; Dallner, G; Parmryd, I | 1 |
| Fawcett, TW; Gorospe, M; Holbrook, NJ; Hudgins, WR; Shack, S | 1 |
| Antoni, I; Bentzen, CL; Flach, J; Niesor, EJ; Villemin, P | 1 |
| Arpaia, M; Banfi, C; Mussoni, L; Sironi, L; Tremoli, E | 1 |
| Buurman, SW; Frenkel, J; Houten, SM; Kuis, W; Mandey, SH; Rijkers, GT; Wanders, RJ; Waterham, HR | 1 |
| Iguchi, T; Ikeda, Y; Kizaki, M; Miyakawa, Y; Yamamoto, K | 1 |
| Frenkel, J; Houten, SM; Waterham, HR | 1 |
| Mönkkönen, J; Ollikainen, J; Taskinen, M; Töyräs, A | 1 |
| Csonka, C; Csont, T; Ferdinandy, P; Giricz, Z; Onody, A | 1 |
| DUVIVIER, J; GOSSELIN, L | 1 |
| Brown, MS; DeBose-Boyd, RA; Goldstein, JL; Sever, N; Song, BL; Yabe, D | 1 |
| Domínguez, A; Ruiz-Velasco, N; Vega, MA | 1 |
| Doitsidou, M; Farber, SA; Ho, SY; Raz, E; Thorpe, JL | 1 |
| Deng, Y; DeRose, RA; Farber, SA; Ho, SY; Santana, E; Thorpe, JL | 1 |
| Brunskill, NJ; Chana, RS | 1 |
| Kuroda, M; Nagasaki, S; Ohta, T | 1 |
| Body, JJ; Chaboteaux, C; Durbecq, V; Journe, F; Larsimont, D; Laurent, G; Nonclercq, D | 1 |
| Head, DD; Kotti, T; McKenna, CE; Russell, DW | 1 |
| Auriola, S; Mönkkönen, H; Mönkkönen, J; Räikkönen, J | 1 |
| Dushkin, MI; Feofanova, NA; Khoshchenko, OM; Schwartz, YSh | 1 |
| Engelmann, U; Epplen, R; Heidenreich, A; Ohlmann, CH; Stöckle, M | 1 |
| Choi, ES; Chung, YR; Keasling, JD; Kim, JY; Kim, SW; Shah, AA; Wang, C; Yoon, SH | 1 |
| Hamashima, H; Hirohara, M; Inoue, Y; Kaneko, M; Togashi, N | 1 |
| Li, L; Mans, RA; McMahon, LL | 1 |
| Capecchi, PL; Capperucci, C; Ferrata, P; Frediani, B; Galeazzi, M; Laghi-Pasini, F; Lazzerini, PE; Niccolini, S; Spreafico, A | 1 |
| Choi, ES; Jang, HJ; Kim, JY; Kim, SW; Lee, SG; Wang, C; Yoon, SH; Zhou, J | 1 |
| Csonka, C; Csont, T; Ferdinandy, P; Görbe, A; Kocsis, GF; Murlasits, Z; Pálóczi, J; Szűcs, G; Török, S | 1 |
| Morris, AJ; Onono, F; Spielmann, HP; Subramanian, KL; Subramanian, T; Sunkara, M | 1 |
| Coates, DE; Cullinan, MP; Drummond, BK; Milne, T; Seymour, GJ; Zafar, S | 1 |
| Ikebe, T; Kajiya, H; Nagaoka, Y; Okabe, K; Ozeki, S | 1 |
| Mo, H; Torabi, S | 1 |
| Bissinger, BW; Egekwu, N; Khalil, SM; Mitchell, RD; Roe, RM; Sonenshine, DE; Zhu, J | 1 |
| Choi, ES; Kim, SW; Park, JE; Wang, C | 1 |
3 review(s) available for farnesol and mevalonic acid
| Article | Year |
|---|---|
Regulation of the mevalonate pathway.
Topics: Animals; Cell Division; Cholesterol; Farnesol; Gene Expression Regulation; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Synthase; Mevalonic Acid; Receptors, LDL; Sterols; Transcription, Genetic | 1990 |
Conversion of mevalonic acid into prenyl hydrocarbons as exemplified by the synthesis of squalene.
Topics: Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, DEAE-Cellulose; Chromatography, Thin Layer; Deuterium; Farnesol; Glycols; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mevalonic Acid; Models, Chemical; Models, Structural; Optical Rotatory Dispersion; Phosphoric Acids; Phosphorus Isotopes; Squalene; Stereoisomerism; Terpenes; Tritium; Yeasts | 1970 |
Isoprenoid biosynthesis in hereditary periodic fever syndromes and inflammation.
Topics: Cholesterol; Diterpenes; Familial Mediterranean Fever; Farnesol; Humans; Inflammation; Mevalonic Acid; Models, Biological; Mutation; Phosphotransferases (Alcohol Group Acceptor); Polyisoprenyl Phosphates; Syndrome | 2003 |
109 other study(ies) available for farnesol and mevalonic acid
| Article | Year |
|---|---|
Symmetry of squalene epoxidation in vivo.
Topics: Acetyl Coenzyme A; Animals; Cholesterol; Epoxy Compounds; Farnesol; Lanosterol; Liver; Mevalonic Acid; Rats; Squalene | 1977 |
Formation of steroids by the pregnant mare. VI. Metabolism of [14C]farnesyl pyrophosphate and [3H]dehydroepiandrosterone injected into the fetus.
Topics: Animals; Dehydroepiandrosterone; Farnesol; Female; Fetus; Horses; Maternal-Fetal Exchange; Mevalonic Acid; Polyisoprenyl Phosphates; Pregnancy; Pregnancy, Animal; Sesquiterpenes; Steroids | 1978 |
[Identification of farnesol as an intermediate in the biosynthesis of cantharidin from mevalonolactone].
Topics: Animals; Cantharidin; Coleoptera; Farnesol; Lactones; Male; Mevalonic Acid | 1977 |
Inhibition of liver prenyltransferase by alkyl phosphonates and phosphonophosphates.
Topics: Animals; Binding Sites; Cholesterol; Dimethylallyltranstransferase; Farnesol; Kinetics; Liver; Mevalonic Acid; Organophosphonates; Polyisoprenyl Phosphates; Sesquiterpenes; Structure-Activity Relationship; Swine; Transferases | 1978 |
Studies in terpenoid biosynthesis. Part 18. Biosynthesis of culmorin.
Topics: Cyclization; Farnesol; Fusarium; Mevalonic Acid; Organophosphorus Compounds; Sesquiterpenes | 1976 |
Abnormal induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase in leukocytes from subjects with heterozygous familial hypercholesterolemia.
Topics: Acetates; Adolescent; Adult; Alcohol Oxidoreductases; Enzyme Induction; Farnesol; Glutarates; Heterozygote; Humans; Hypercholesterolemia; Leukocytes; Lipids; Male; Mevalonic Acid; Middle Aged; Squalene; Sterols; Time Factors | 1975 |
Squalene synthase-deficient mutant of Chinese hamster ovary cells.
Topics: Acetates; Animals; CHO Cells; Cholesterol; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cricetinae; Farnesol; Farnesyl-Diphosphate Farnesyltransferase; Flow Cytometry; Hydroxymethylglutaryl CoA Reductases; Lovastatin; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mevalonic Acid; Mutagenesis | 1992 |
In vivo farnesylation of rat rhodopsin kinase.
Topics: Animals; Eye Proteins; Farnesol; G-Protein-Coupled Receptor Kinase 1; Light; Membranes; Mevalonic Acid; Phosphorylation; Protein Kinases; Protein Processing, Post-Translational; Rats; Rod Cell Outer Segment | 1992 |
Isopentenoid synthesis in isolated embryonic Drosophila cells: absolute, basal mevalonate synthesis rate determination.
Topics: Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Drosophila; Embryo, Nonmammalian; Farnesol; Hydroxymethylglutaryl CoA Reductases; Mevalonic Acid; Terpenes; Tritium | 1992 |
Post-translational processing of Schizosaccharomyces pombe YPT proteins.
Topics: Amino Acid Sequence; Chromatography, High Pressure Liquid; Diterpenes; DNA; Electrophoresis, Polyacrylamide Gel; Farnesol; Fungal Proteins; GTP-Binding Proteins; Hydroxylamine; Hydroxylamines; Methylation; Mevalonic Acid; Molecular Sequence Data; Oncogene Protein p21(ras); Protein Biosynthesis; Protein Processing, Post-Translational; rab GTP-Binding Proteins; Saccharomyces cerevisiae Proteins; Schizosaccharomyces | 1992 |
Biosynthetic studies of marine lipids. 35. The demonstration of de novo sterol biosynthesis in sponges using radiolabeled isoprenoid precursors.
Topics: Animals; Farnesol; Mevalonic Acid; Porifera; Squalene; Sterols; Tritium | 1991 |
S-farnesylation and methyl esterification of C-terminal domain of yeast RAS2 protein prior to fatty acid acylation.
Topics: Acylation; Amino Acid Sequence; Chromatography, High Pressure Liquid; Esters; Farnesol; Fatty Acids; Fungal Proteins; GTP-Binding Proteins; Methylation; Mevalonic Acid; Molecular Sequence Data; Protein Processing, Post-Translational; ras Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 1991 |
Human liver alcohol dehydrogenases catalyze the oxidation of the intermediary alcohols of the shunt pathway of mevalonate metabolism.
Topics: 1-Propanol; Acyclic Monoterpenes; Alcohol Dehydrogenase; Farnesol; Humans; Isoenzymes; Kinetics; Liver; Mevalonic Acid; Oxidation-Reduction; Propanols; Substrate Specificity; Terpenes | 1991 |
Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation.
Topics: Animals; Anticholesteremic Agents; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Exons; Farnesol; Genetic Vectors; Humans; Lovastatin; Mevalonic Acid; Mice; Mutation; Oligonucleotide Probes; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Transfection | 1990 |
The gamma subunit of transducin is farnesylated.
Topics: Animals; Cattle; Diterpenes; Farnesol; Gas Chromatography-Mass Spectrometry; In Vitro Techniques; Leucine; Macromolecular Substances; Mevalonic Acid; Protein Processing, Post-Translational; Retina; Transducin | 1990 |
Isolation and properties of yeast mutants affected in farnesyl diphosphate synthetase.
Topics: Acyclic Monoterpenes; Cell Membrane Permeability; Dimethylallyltranstransferase; Ergosterol; Farnesol; Genes, Fungal; Genetic Complementation Test; Mevalonic Acid; Mutation; Phenotype; Restriction Mapping; Saccharomyces cerevisiae; Terpenes | 1990 |
p21ras is modified by a farnesyl isoprenoid.
Topics: Amino Acid Sequence; Animals; Cells, Cultured; Farnesol; Genes, ras; Mevalonic Acid; Mice; Molecular Sequence Data; Oncogene Protein p21(ras); Transfection | 1989 |
Characterization of isoprenoid involved in the post-translational modification of mammalian cell proteins.
Topics: Animals; Cell Line; Electrophoresis, Polyacrylamide Gel; Farnesol; Leukemia, Erythroblastic, Acute; Mevalonic Acid; Mice; Neoplasm Proteins; Protein Processing, Post-Translational | 1989 |
Isopentenoid synthesis in isolated embryonic Drosophila cells. Farnesol catabolism and omega-oxidation.
Topics: Animals; Cell Line; Drosophila; Farnesol; Isomerism; Kinetics; Liver; Male; Mevalonic Acid; Oxidation-Reduction; Polyisoprenyl Phosphates; Rats; Rats, Inbred Strains; Sesquiterpenes | 1988 |
Characterization and regulation of HMG-CoA reductase during a cycle of juvenile hormone synthesis.
Topics: Animals; Cockroaches; Corpora Allata; Cycloheximide; Enzyme Activation; Farnesol; Female; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Kinetics; Lovastatin; Mevalonic Acid; Microsomes; Sesquiterpenes; Stereoisomerism | 1987 |
Studies on the biosynthesis of tetrahymanol in Tetrahymena pyriformis. The mechanism of inhibition by cholesterol.
Topics: Acetates; Alcohol Oxidoreductases; Carbon Radioisotopes; Cholesterol; Chromatography, DEAE-Cellulose; Chromatography, Thin Layer; Diphosphates; Farnesol; Ligases; Mevalonic Acid; Oxygenases; Phosphoric Acids; Polycyclic Compounds; Squalene; Tetrahymena pyriformis; Triterpenes; Tritium | 1974 |
Prequalene pyrophosphate. A normal intermediate in squalene biosynthesis.
Topics: Animals; Butanols; Dimethylformamide; Dose-Response Relationship, Drug; Farnesol; Liver; Male; Methanol; Mevalonic Acid; Microsomes; NAD; NADP; Oxidation-Reduction; Phosphoric Acids; Rats; Saccharomyces cerevisiae; Squalene; Sterols; Tritium | 1974 |
[Utilization of farnesyl pyrophosphate by rat liver microsomes in the absence of nicotinamide adenine dinucleotides].
Topics: Animals; Carbon Isotopes; Chromatography, Thin Layer; Diphosphates; Farnesol; In Vitro Techniques; Liver; Mevalonic Acid; Microsomes; NAD; NADP; Radiometry; Rats; Squalene | 1964 |
Studies on the biosynthesis of cholesterol. XX. Steric course of decarboxylation of 5-pyrophosphomevalonate and of the carbon to carbon bond formation in the biosynthesis of farnesyl pyrophosphate.
Topics: Alkenes; Chemical Phenomena; Chemistry; Cholesterol; Chromatography, Gas; Deuterium; Diphosphates; Ethers; Farnesol; Mevalonic Acid; Spectrum Analysis | 1966 |
The inhibition of mevalonic kinase by geranyl and farnesyl pyrophosphates.
Topics: Adenosine Triphosphate; Animals; Carbon Isotopes; Computers; Diphosphates; Farnesol; Kinetics; Magnesium; Mevalonic Acid; Phosphotransferases; Plants, Medicinal; Swine; Terpenes | 1968 |
Lipid metabolism in helminth parasites--VI. Synthesis of 2-cis,6-trans farnesol by Hymenolepis diminuta (Cestoda).
Topics: Acetates; Animals; Carbon Isotopes; Cestoda; Cholesterol; Chromatography, Gas; Farnesol; Glutarates; Invertebrate Hormones; Mevalonic Acid; Phosphoric Acids; Rats; Squalene; Stereoisomerism; Terpenes | 1969 |
Biosynthesis of gossypol. Incorporation of mevalonate-2-14C and isoprenyl pyrophosphates.
Topics: Adenosine Triphosphate; Alcohols; Carbon Isotopes; Farnesol; Gossypol; Mevalonic Acid; Phosphoric Acids; Plants; Stereoisomerism; Terpenes | 1970 |
The characterization and stereochemistry of biosynthesis of dolichols in rat liver.
Topics: Alcohols; Animals; Carbon Isotopes; Chromatography; Diphosphates; Farnesol; Female; Isomerases; Liver; Mevalonic Acid; Rats; Stereoisomerism; Terpenes; Transferases; Tritium | 1970 |
The activity and kinetic properties of mevalonate kinase in superovulated rat ovary.
Topics: Acetates; Adenosine Triphosphate; Alkenes; Animals; Carbon Isotopes; Chorionic Gonadotropin; Farnesol; Female; Gonadotropins, Equine; Kinetics; Luteinizing Hormone; Magnesium; Mevalonic Acid; Ovary; Ovulation; Phosphoric Acids; Phosphotransferases; Rats; Steroids; Terpenes | 1970 |
The effects of fasting, refeeding, and time of day on the levels of enzymes effecting the conversion of -hydroxy- -methylglutaryl-coenzyme A to squalene.
Topics: Acetates; Alcohol Oxidoreductases; Alkenes; Allyl Compounds; Animals; Carbon Isotopes; Carboxy-Lyases; Cholesterol; Circadian Rhythm; Dietary Fats; Farnesol; Fasting; Glutarates; Isomerases; Kinetics; Ligases; Liver; Male; Mevalonic Acid; Microsomes, Liver; Phosphoric Acids; Phosphotransferases; Rats; Squalene; Subcellular Fractions; Transferases | 1972 |
Inhibition of sterol biosynthesis by bacitracin.
Topics: Alkaline Phosphatase; Animals; Bacitracin; Carbon Isotopes; Depression, Chemical; Diphosphates; Escherichia coli; Farnesol; Liver; Male; Mevalonic Acid; Nitrophenols; Phosphoric Monoester Hydrolases; Rats; Rats, Inbred Strains; Squalene; Sterols; Terpenes; Tritium | 1972 |
Plant sterol metabolism. Demonstration and identification of a biosynthetic intermediate between farnesyl PP and squalene in a higher plant.
Topics: Acetates; Acetylation; Alcohols; Alkaline Phosphatase; Anhydrides; Carbon Isotopes; Cell-Free System; Chromatography, Thin Layer; Culture Techniques; Farnesol; Mevalonic Acid; Microsomes; NAD; Organophosphorus Compounds; Phosphoric Acids; Phytosterols; Plants; Squalene; Tritium | 1972 |
Occurrence of the enzymes effecting the conversion of acetyl CoA to squalene in homogenates of hog aorta.
Topics: Acetyl Coenzyme A; Alcohol Oxidoreductases; Alkenes; Animals; Aorta; Carbon Isotopes; Chromatography, DEAE-Cellulose; Chromatography, Gas; Chromatography, Paper; Coenzyme A; Farnesol; Glutarates; Hemiterpenes; Ligases; Mevalonic Acid; Multienzyme Complexes; Muscle, Smooth; Organophosphorus Compounds; Phosphoric Acids; Squalene; Subcellular Fractions; Swine | 1973 |
Extensive incorporation of (2-14C) mevalonic acid into cholesterol precursors by human platelets in vitro.
Topics: Acetates; Animals; Autoradiography; Blood Platelets; Carbon Dioxide; Carbon Radioisotopes; Cholesterol; Dealkylation; Farnesol; Fatty Acids; Fatty Acids, Unsaturated; Humans; Lanosterol; Lipids; Liver; Mevalonic Acid; Phosphoric Acids; Rats; Squalene; Sterols | 1973 |
Isoprenoid biosynthesis in a cell-free system from pea shoots.
Topics: Carbon Isotopes; Chromatography, Thin Layer; Farnesol; In Vitro Techniques; Lipids; Mevalonic Acid; NAD; NADP; Plants, Edible; Squalene; Terpenes | 1967 |
On the biosynthesis of juvenile hormone in the adult Cecropia moth.
Topics: Acetates; Biological Evolution; Carbon Isotopes; Farnesol; Insecta; Juvenile Hormones; Methionine; Methylation; Mevalonic Acid; Propionates; Time Factors; Tritium | 1971 |
The stereochemistry of hydrogen transfer from NADPH catalysed by 3-hydroxy-3-methylglutaryl-coenzyme A reductase from rat liver.
Topics: Alcohol Oxidoreductases; Aldehydes; Animals; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Farnesol; Female; Glutarates; Hydrogen; Liver; Mevalonic Acid; Microsomes, Liver; NADP; Rats; Tritium; Valerates | 1972 |
Some studies on the biosynthesis of ubiguinone, isoprenoid alcohols, squalene and sterols by marine invertebrates.
Topics: Alcohols; Animals; Annelida; Carbon Isotopes; Chromatography, Thin Layer; Cnidaria; Crustacea; Echinodermata; Farnesol; Fatty Alcohols; Invertebrates; Marine Biology; Mevalonic Acid; Mollusca; Porifera; Squalene; Sterols; Terpenes; Ubiquinone | 1972 |
The stereochemistry of the reduction of mevaldic acid-coenzyme A hemithioacetal by rat liver 3-hydroxy-3-methylglutaryl coenzyme A reductase.
Topics: Alcohol Oxidoreductases; Aldehydes; Alkaline Phosphatase; Animals; Carbon Isotopes; Catalysis; Chemical Phenomena; Chemistry; Coenzyme A; Farnesol; Glutarates; Liver; Mevalonic Acid; NADP; Rats; Sulfides; Tritium; Valerates | 1972 |
Biosynthesis of trans, trans- and cis, trans-farnesols by soluble enzymes from tissue cultures of Andrographis paniculata.
Topics: Chemical Phenomena; Chemistry; Culture Techniques; Farnesol; Mevalonic Acid; Plants | 1974 |
Dolichols, ubiquinones, geranylgeraniol and farnesol as the major metabolites of mevalonate in Phytophthora cactorum.
Topics: Alcohols; Carbon Isotopes; Chromatography, Thin Layer; Farnesol; Fatty Alcohols; Fungi; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mevalonic Acid; Terpenes; Tritium; Ubiquinone | 1972 |
Lessons learnt from small molecules.
Topics: Acetates; Animals; Biochemistry; Cholesterol; Farnesol; Fatty Acids; Female; Glycerol; Goats; History, 20th Century; Kinetics; Lactation; Lactose; Mammary Glands, Animal; Mevalonic Acid; Pregnancy; Rabbits; Radioisotopes; Transferases; Triglycerides; United Kingdom | 1970 |
[Biosynthesis of squalene with the help of microsomes originating from the tissue of tobacco cultivated in vitro].
Topics: Culture Techniques; Farnesol; Mevalonic Acid; Microsomes; Nicotiana; Plant Extracts; Plants, Toxic; Squalene | 1967 |
Oestrogen biosynthesis in the pregnant mare.
Topics: Acetates; Alkenes; Androstenedione; Animals; Chemical Phenomena; Chemistry; Cholesterol; Dehydroepiandrosterone; Equilin; Estrogens; Farnesol; Female; Hemiterpenes; Horses; Maternal-Fetal Exchange; Mevalonic Acid; Organophosphorus Compounds; Polyisoprenyl Phosphates; Pregnancy; Pregnancy, Animal; Sesquiterpenes; Squalene; Tyrosine | 1981 |
Pathogenesis of atherosclerosis and the role of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors.
Topics: Animals; Anticholesteremic Agents; Arteriosclerosis; Cell Division; Cell Movement; Cells, Cultured; Cholesterol Esters; Diterpenes; Farnesol; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Macrophages, Peritoneal; Male; Mevalonic Acid; Mice; Mice, Inbred BALB C; Muscle, Smooth, Vascular; Pravastatin; Rabbits; Rats; Rats, Sprague-Dawley; Simvastatin | 1995 |
Farnesyl acetate, a derivative of an isoprenoid of the mevalonate pathway, inhibits DNA replication in hamster and human cells.
Topics: Animals; Cells, Cultured; CHO Cells; Cricetinae; DNA; DNA Replication; Farnesol; Flow Cytometry; HeLa Cells; Humans; Mevalonic Acid; S Phase | 1995 |
Farnesol is utilized for protein isoprenylation and the biosynthesis of cholesterol in mammalian cells.
Topics: Animals; Cell Line; Chlorocebus aethiops; Cholesterol; Cysteine; Diterpenes; Electrophoresis, Polyacrylamide Gel; Farnesol; Glioma; Kinetics; Mevalonic Acid; Neoplasm Proteins; Protein Biosynthesis; Protein Prenylation; Proteins; Rats; Tritium; Tumor Cells, Cultured; Ubiquinone | 1995 |
Inhibition of human vascular smooth muscle cell proliferation by lovastatin: the role of isoprenoid intermediates of cholesterol synthesis.
Topics: Adenine; Cell Division; Cells, Cultured; Cholesterol; Coronary Disease; Farnesol; Humans; Isopentenyladenosine; L-Lactate Dehydrogenase; Lovastatin; Mevalonic Acid; Muscle, Smooth, Vascular; Saphenous Vein | 1994 |
Effect of simvastatin, an inhibitor of hydroxy-methylglutaryl coenzyme A reductase, on the growth of human Ito cells.
Topics: Actins; Adenine; Analysis of Variance; Autoradiography; Cell Division; Cells, Cultured; Cholesterol, LDL; Desmin; DNA; Farnesol; Fibroblasts; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isopentenyladenosine; Liver; Lovastatin; Mevalonic Acid; Simvastatin | 1994 |
Identification of farnesol as the non-sterol derivative of mevalonic acid required for the accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Topics: Animals; Cattle; Cell Membrane; Cell Membrane Permeability; Cells, Cultured; Culture Techniques; Digitonin; Farnesol; Hydrolysis; Hydroxymethylglutaryl CoA Reductases; Mevalonic Acid; Polyisoprenyl Phosphates; Sesquiterpenes | 1994 |
Relationship between mevalonate pathway and arterial myocyte proliferation: in vitro studies with inhibitors of HMG-CoA reductase.
Topics: Acyclic Monoterpenes; Animals; Aorta; Cell Division; Cells, Cultured; Cholesterol; Diterpenes; Dose-Response Relationship, Drug; Farnesol; Fatty Acids, Monounsaturated; Femoral Artery; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Male; Mevalonic Acid; Muscle, Smooth, Vascular; Pravastatin; Rats; Rats, Sprague-Dawley; Simvastatin; Squalene; Terpenes | 1993 |
Biosynthesis of isoprenoid compounds in Schistosoma mansoni.
Topics: Alcohols; Animals; Chromatography, Thin Layer; Dolichols; Farnesol; Lipid Metabolism; Lipids; Mevalonic Acid; Phospholipids; Schistosoma mansoni; Triglycerides; Ubiquinone | 1993 |
Lovastatin inhibits proliferation of rat mesangial cells.
Topics: Adenine; Animals; Cell Division; Cells, Cultured; DNA; DNA Replication; Dose-Response Relationship, Drug; Farnesol; Glomerular Mesangium; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isopentenyladenosine; Kinetics; Lovastatin; Mevalonic Acid; Rats; Thymidine | 1993 |
Evidence for farnesol-mediated isoprenoid synthesis regulation in a halophilic archaeon, Haloferax volcanii.
Topics: Acetates; Acetic Acid; Alkyl and Aryl Transferases; Farnesol; Farnesyltranstransferase; Fatty Alcohols; Halobacteriales; Hydroxymethylglutaryl CoA Reductases; Lipids; Mevalonic Acid; Phosphorylation; Polyisoprenyl Phosphates; Sesquiterpenes; Transferases | 1996 |
Identification of spinach farnesyl protein transferase. Dithiothreitol as an acceptor in vitro.
Topics: Alkyl and Aryl Transferases; Blotting, Western; Chlorides; Cytoplasm; Dithiothreitol; Edetic Acid; Enzyme Activation; Enzyme Inhibitors; Farnesol; Hydrogen-Ion Concentration; Magnesium Chloride; Mass Spectrometry; Mevalonic Acid; Polyisoprenyl Phosphates; Polypropylenes; Protein Prenylation; Sesquiterpenes; Spinacia oleracea; Temperature; Transferases; Zinc Compounds | 1995 |
Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation by the nonsterol mevalonate metabolite farnesol in vivo.
Topics: Animals; Calcium-Binding Proteins; Calnexin; Cell Compartmentation; CHO Cells; Cricetinae; Farnesol; Farnesyl-Diphosphate Farnesyltransferase; Hydroxymethylglutaryl CoA Reductases; Mevalonic Acid; Solubility | 1996 |
Farnesol is not the nonsterol regulator mediating degradation of HMG-CoA reductase in rat liver.
Topics: Animals; Anticholesteremic Agents; Bridged Bicyclo Compounds, Heterocyclic; Chromatography, High Pressure Liquid; Cycloheximide; Enzyme Inhibitors; Farnesol; Farnesyl-Diphosphate Farnesyltransferase; Half-Life; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Liver; Lovastatin; Male; Mevalonic Acid; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Time Factors; Tricarboxylic Acids | 1996 |
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor impairs cell p4fferentiation in cultured adipogenic cells (3T3-L1).
Topics: 3T3 Cells; Acyclic Monoterpenes; Animals; Azo Compounds; Cell Differentiation; Cholesterol; Enzyme Inhibitors; Farnesol; Glycerolphosphate Dehydrogenase; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Metabolism; Lovastatin; Mevalonic Acid; Mice; Terpenes | 1996 |
Farnesol and geranylgeraniol induce actin cytoskeleton disorganization and apoptosis in A549 lung adenocarcinoma cells.
Topics: Actins; Acyclic Monoterpenes; Apoptosis; Cholesterol; Cytoskeleton; Desmosterol; Diterpenes; Enzyme Inhibitors; Farnesol; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Squalene; Terpenes; Tumor Cells, Cultured | 1996 |
The effects of pravastatin, an HMG-CoA reductase inhibitor, on cell viability and DNA production of rat hepatocytes.
Topics: Adenine; Animals; Apoptosis; Cell Survival; Cells, Cultured; Cholesterol, LDL; Chromatin; DNA; Enzyme Inhibitors; Epidermal Growth Factor; Farnesol; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isopentenyladenosine; Liver; Male; Mevalonic Acid; Pravastatin; Rats; Rats, Wistar | 1996 |
Lovastatin inhibits gene expression of type-I scavenger receptor in THP-1 human macrophages.
Topics: Cell Line; Dactinomycin; Enzyme Inhibitors; Farnesol; Gene Expression; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Macrophages; Membrane Proteins; Mevalonic Acid; Receptors, Immunologic; Receptors, Lipoprotein; Receptors, Scavenger; RNA, Messenger; Scavenger Receptors, Class B; Tetradecanoylphorbol Acetate | 1996 |
Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts.
Topics: Actins; Alkyl and Aryl Transferases; Animals; Benzamides; Cell Cycle; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Cytoskeleton; Diterpenes; DNA; Enzyme Inhibitors; Farnesol; Fibroblasts; G1 Phase; Genes, ras; GTP-Binding Proteins; Lovastatin; Methionine; Mevalonic Acid; Mice; Protein Prenylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; rap GTP-Binding Proteins; ras Proteins; Resting Phase, Cell Cycle; S Phase; Transferases | 1996 |
Epidermal injury stimulates prenylation in the epidermis of hairless mice.
Topics: Alkyl and Aryl Transferases; Animals; Basal Metabolism; Enzyme Inhibitors; Epidermis; Farnesol; Farnesyltranstransferase; Male; Mevalonic Acid; Mice; Mice, Hairless; Molecular Weight; Organophosphonates; Protein Prenylation; Radioligand Assay; Time Factors; Transferases; Tritium | 1997 |
Geranylgeraniol promotes entry of UT-2 cells into the cell cycle in the absence of mevalonate.
Topics: Animals; Cell Cycle; CHO Cells; Cricetinae; Cricetulus; Diterpenes; Farnesol; Hydroxymethylglutaryl CoA Reductases; Mevalonic Acid; Protein Prenylation; Protein Processing, Post-Translational; S Phase | 1997 |
Inhibition of cholesterol synthesis by squalene synthase inhibitors does not induce myotoxicity in vitro.
Topics: Analysis of Variance; Animals; Animals, Newborn; Anticholesteremic Agents; Butylamines; Cells, Cultured; Cholesterol; Diterpenes; Enzyme Inhibitors; Farnesol; Farnesyl-Diphosphate Farnesyltransferase; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; L-Lactate Dehydrogenase; Lovastatin; Mevalonic Acid; Muscle, Skeletal; Pravastatin; Pregnancy; Prodrugs; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Squalene; Sulfonic Acids | 1997 |
Farnesol as a regulator of HMG-CoA reductase degradation: characterization and role of farnesyl pyrophosphatase.
Topics: Animals; beta-Galactosidase; CHO Cells; Cricetinae; Edetic Acid; Enzyme Inhibitors; Farnesol; Hydroxymethylglutaryl CoA Reductases; Magnesium; Mevalonic Acid; Organophosphonates; Phosphinic Acids; Pyrophosphatases; Recombinant Fusion Proteins | 1997 |
Expression cloning of a novel farnesylated protein, RDJ2, encoding a DnaJ protein homologue.
Topics: Alkyl and Aryl Transferases; Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; DNA, Complementary; Escherichia coli Proteins; Farnesol; Gene Expression; Heat-Shock Proteins; HSP40 Heat-Shock Proteins; Mevalonic Acid; Molecular Sequence Data; Polyisoprenyl Phosphates; Protein Prenylation; Rats; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Sesquiterpenes | 1997 |
Lovastatin induces apoptosis in malignant mesothelioma cells.
Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Apoptosis; Cell Division; Cell Line; Cell Membrane; Cell Survival; Cytosol; DNA, Neoplasm; Dose-Response Relationship, Drug; Farnesol; Fibroblasts; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mesothelioma; Mevalonic Acid; Protein Prenylation; ras Proteins; Tumor Cells, Cultured | 1998 |
Geranylgeraniol overcomes the block of cell proliferation by lovastatin in C6 glioma cells.
Topics: Animals; Cell Division; Diterpenes; Electrophoresis, Polyacrylamide Gel; Farnesol; Glioma; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Molecular Weight; Nerve Tissue Proteins; Polyisoprenyl Phosphates; Protein Prenylation; Rats; Thymidine; Tumor Cells, Cultured | 1998 |
Massive production of farnesol-derived dicarboxylic acids in mice treated with the squalene synthase inhibitor zaragozic acid A.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Chromatography, Gas; Chromatography, High Pressure Liquid; Dicarboxylic Acids; Enzyme Inhibitors; Farnesol; Farnesyl-Diphosphate Farnesyltransferase; Female; In Vitro Techniques; Kidney; Liver; Mevalonic Acid; Mice; Tricarboxylic Acids | 1998 |
Alpha1-adrenoreceptor stimulation causes vascular smooth muscle cell hypertrophy: a possible role for isoprenoid intermediates.
Topics: Adrenergic alpha-Agonists; Animals; Anticholesteremic Agents; Aorta, Thoracic; Carbon Radioisotopes; Cell Count; Cells, Cultured; Cholesterol; Drug Interactions; Farnesol; Hypertrophy; Leucine; Lovastatin; Mevalonic Acid; Muscle, Smooth, Vascular; Phenylephrine; Protein Prenylation; Rats; Receptors, Adrenergic, alpha-1; Transferases | 1998 |
Analysis of isoprenoid biosynthesis in peroxisomal-deficient Pex2 CHO cell lines.
Topics: Acetates; Animals; Cell Membrane Permeability; CHO Cells; Cholesterol; Cricetinae; Cytosol; Dolichol Phosphates; Farnesol; Hydroxymethylglutaryl CoA Reductases; Immunoblotting; Lanosterol; Mevalonic Acid; Microbodies; Mutation; Polyisoprenyl Phosphates; Tritium | 1998 |
The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Division; Diphosphonates; Diterpenes; Enzyme Inhibitors; Farnesol; Humans; Lovastatin; Mevalonic Acid; Multiple Myeloma; Protein Prenylation; Tumor Cells, Cultured | 1998 |
Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro.
Topics: Alendronate; Animals; Bone Resorption; Cell Differentiation; Cells, Cultured; Cholesterol; Clodronic Acid; Diterpenes; Enzyme Activation; Farnesol; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Mice; Osteoclasts; Protein Kinases; Rabbits; Skull; Squalene | 1999 |
In vivo prenylation of rat proteins: modification of proteins with penta- and hexaprenyl groups.
Topics: Animals; Farnesol; Kidney; Mevalonic Acid; Protein Prenylation; Proteins; Rats; Rats, Sprague-Dawley; Subcellular Fractions; Tritium | 1999 |
Inhibition of farnesylation blocks growth but not differentiation in FRTL-5 thyroid cells.
Topics: Animals; Cattle; Cell Differentiation; Cell Division; Cell Line; DNA; Farnesol; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Protein Prenylation; Rats; Thyroid Gland; Thyrotropin | 1999 |
Role of RhoA activation in the growth and morphology of a murine prostate tumor cell line.
Topics: Actin Cytoskeleton; Adenocarcinoma; Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Apoptosis; Cell Adhesion; Cell Division; Cell Size; Diterpenes; Drug Interactions; Enzyme Activation; Farnesol; G1 Phase; Genes, ras; GTP-Binding Proteins; Guanosine Triphosphate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Mevalonic Acid; Mice; Mice, Transgenic; Polyisoprenyl Phosphates; Prostatic Neoplasms; Protein Prenylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras); rac GTP-Binding Proteins; rhoA GTP-Binding Protein; Sesquiterpenes; Tumor Cells, Cultured | 1999 |
Protein prenylation in spinach chloroplasts.
Topics: Animals; Cell Fractionation; Chloroplasts; Cotyledon; Diterpenes; Farnesol; Gas Chromatography-Mass Spectrometry; Mammals; Mevalonic Acid; Plant Proteins; Protein Prenylation; Protein Synthesis Inhibitors; Spinacia oleracea; Tritium | 1999 |
Activation of the cholesterol pathway and Ras maturation in response to stress.
Topics: Adenocarcinoma; Calcium-Calmodulin-Dependent Protein Kinases; Cholesterol; Diterpenes; Farnesol; Genes, ras; Heat-Shock Response; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Lovastatin; Male; Mevalonic Acid; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Prostatic Neoplasms; Protein Prenylation; ras Proteins; Sterols; Stress, Physiological | 1999 |
The mevalonate/isoprenoid pathway inhibitor apomine (SR-45023A) is antiproliferative and induces apoptosis similar to farnesol.
Topics: Anticholesteremic Agents; Antineoplastic Agents; Apoptosis; Cell Division; Diphosphonates; Dose-Response Relationship, Drug; Farnesol; Humans; Hydroxycholesterols; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Molecular Mimicry; Simvastatin; Terpenes; Tumor Cells, Cultured | 2000 |
Fluvastatin inhibits basal and stimulated plasminogen activator inhibitor 1, but induces tissue type plasminogen activator in cultured human endothelial cells.
Topics: Cells, Cultured; Depression, Chemical; Diterpenes; Endothelium, Vascular; Farnesol; Fatty Acids, Monounsaturated; Fluvastatin; Gene Expression Regulation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lipopolysaccharides; Mevalonic Acid; Plasminogen Activator Inhibitor 1; RNA, Messenger; Tetradecanoylphorbol Acetate; Tissue Plasminogen Activator; Tumor Necrosis Factor-alpha; Umbilical Veins | 2000 |
Lack of isoprenoid products raises ex vivo interleukin-1beta secretion in hyperimmunoglobulinemia D and periodic fever syndrome.
Topics: Antibodies; CD2 Antigens; CD28 Antigens; Cell Division; Cells, Cultured; Child; Diterpenes; Familial Mediterranean Fever; Farnesol; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypergammaglobulinemia; Immunoglobulin D; Interleukin-1; Lovastatin; Male; Mevalonic Acid; Phosphotransferases (Alcohol Group Acceptor); Polyisoprenyl Phosphates; T-Lymphocytes | 2002 |
Nitrogen-containing bisphosphonates induce S-phase cell cycle arrest and apoptosis of myeloma cells by activating MAPK pathway and inhibiting mevalonate pathway.
Topics: Apoptosis; Cell Division; Cell Line, Tumor; Checkpoint Kinase 1; Diphosphonates; Diterpenes; Enzyme Inhibitors; Farnesol; Humans; Imidazoles; Interleukin-6; MAP Kinase Signaling System; Mevalonic Acid; Multiple Myeloma; Phosphorylation; Protein Kinases; S Phase; Signal Transduction; Stromal Cells | 2003 |
Inhibition of mevalonate pathway is involved in alendronate-induced cell growth inhibition, but not in cytokine secretion from macrophages in vitro.
Topics: Alendronate; Animals; Cell Division; Cell Line; Diterpenes; Farnesol; Lipopolysaccharides; Macrophages; Mevalonic Acid; Mice | 2003 |
Role of cholesterol-enriched diet and the mevalonate pathway in cardiac nitric oxide synthesis.
Topics: Animals; Blotting, Western; Cholesterol, Dietary; Electron Spin Resonance Spectroscopy; Farnesol; Heart; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Lovastatin; Male; Mevalonic Acid; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Superoxides | 2003 |
[BIOSYNTHESIS OF FARNESOL PYROPHOSPHATE AND SQUALENE FROM 2-C14-MEVALONIC ACID BY CELL FRACTIONS OF ADRENAL HOMOGENATE].
Topics: Adrenal Glands; Animals; Cattle; Chromatography; Diphosphates; Farnesol; Ligases; Metabolism; Mevalonic Acid; Microsomes; NADP; Research; Squalene; Terpenes | 1965 |
Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol.
Topics: Alanine; Amino Acid Sequence; Animals; Carrier Proteins; Cell Membrane; CHO Cells; Cricetinae; Diterpenes; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Farnesol; Hydroxymethylglutaryl CoA Reductases; Immunoblotting; Intracellular Signaling Peptides and Proteins; Lysine; Membrane Proteins; Mevalonic Acid; Molecular Sequence Data; Peptides; Plasmids; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Sequence Homology, Amino Acid; Sterols; Subcellular Fractions; Time Factors; Transfection; Ubiquitin | 2003 |
Statins upregulate CD36 expression in human monocytes, an effect strengthened when combined with PPAR-gamma ligands Putative contribution of Rho GTPases in statin-induced CD36 expression.
Topics: Actins; Anticholesteremic Agents; CD36 Antigens; Cells, Cultured; Cytoskeleton; Diterpenes; Farnesol; Gene Expression Regulation; Humans; Lipoproteins, LDL; Lovastatin; Mevalonic Acid; Monocytes; Receptors, Cytoplasmic and Nuclear; rho GTP-Binding Proteins; RNA, Messenger; Transcription Factors; Transcription, Genetic | 2004 |
Germ cell migration in zebrafish is dependent on HMGCoA reductase activity and prenylation.
Topics: Animals; Anticholesteremic Agents; Atorvastatin; Cell Movement; Chemokine CXCL12; Chemokines, CXC; Diterpenes; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Nonmammalian; Enzyme Inhibitors; Farnesol; gamma-Glutamyltransferase; Germ Cells; Heptanoic Acids; Hydroxymethylglutaryl CoA Reductases; Mevalonic Acid; Microinjections; Morpholines; Protein Prenylation; Pyrroles; RNA-Binding Proteins; RNA, Messenger; Somites; Time Factors; Zebrafish; Zebrafish Proteins | 2004 |
Lipid metabolism in zebrafish.
Topics: 4-Chloro-7-nitrobenzofurazan; Alkyl and Aryl Transferases; Animals; Annexin A2; Atorvastatin; Azetidines; Boron Compounds; Caveolin 1; Caveolins; Cell Movement; Cholesterol; Diterpenes; DNA; Embryo, Nonmammalian; Ethylnitrosourea; Ezetimibe; Farnesol; Farnesyltranstransferase; Geranyltranstransferase; Germ Cells; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Metabolism; Lipids; Lovastatin; Mevalonic Acid; Microscopy, Fluorescence; Mutagenesis, Site-Directed; Mutation; Phosphatidylethanolamines; Protein Binding; Protein Prenylation; Pyrroles; Simvastatin; Zebrafish | 2004 |
Thiazolidinediones inhibit albumin uptake by proximal tubular cells through a mechanism independent of peroxisome proliferator activated receptor gamma.
Topics: Albumins; Anilides; Animals; Cells, Cultured; Cholesterol; Chromans; Farnesol; Kidney Tubules, Proximal; Ligands; Mevalonic Acid; Opossums; Polyisoprenyl Phosphates; PPAR gamma; Rosiglitazone; Thiazoles; Thiazolidinediones; Thiazolidines; Troglitazone | 2006 |
Sesquiterpene farnesol inhibits recycling of the C55 lipid carrier of the murein monomer precursor contributing to increased susceptibility to beta-lactams in methicillin-resistant Staphylococcus aureus.
Topics: beta-Lactamases; beta-Lactams; Biological Transport; Cell Wall; Farnesol; Methicillin Resistance; Mevalonic Acid; Microbial Sensitivity Tests; Penicillin-Binding Proteins; Peptidoglycan; Polyisoprenyl Phosphates; Staphylococcus aureus; Xanthophylls | 2007 |
Farnesol, a mevalonate pathway intermediate, stimulates MCF-7 breast cancer cell growth through farnesoid-X-receptor-mediated estrogen receptor activation.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; DNA-Binding Proteins; Farnesol; Gene Silencing; Humans; Ligands; Mevalonic Acid; Microscopy, Fluorescence; Models, Genetic; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Estrogen; Receptors, Progesterone; Receptors, Steroid; Transcription Factors; Transcriptional Activation | 2008 |
Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation.
Topics: Alkyl and Aryl Transferases; Animals; Apolipoproteins E; Cholesterol; Cholesterol 24-Hydroxylase; Dendrites; Disease Models, Animal; Diterpenes; Farnesol; Hippocampus; Hyperlipoproteinemia Type III; Learning; Long-Term Potentiation; Mevalonic Acid; Mice; Mice, Knockout; Prenylation; Steroid Hydroxylases; Time Factors; Transferases | 2008 |
Mevalonate pathway intermediates downregulate zoledronic acid-induced isopentenyl pyrophosphate and ATP analog formation in human breast cancer cells.
Topics: Adenosine Triphosphate; Anticarcinogenic Agents; Breast Neoplasms; Cell Line, Tumor; Diphosphonates; Down-Regulation; Drug Screening Assays, Antitumor; Farnesol; Female; Gene Expression Regulation, Neoplastic; Hemiterpenes; Humans; Imidazoles; Mevalonic Acid; Organophosphorus Compounds; Zoledronic Acid | 2010 |
Effects of cholesterol and nuclear hormone receptor agonists on the production of transforming growth factor-beta in macrophages.
Topics: Alitretinoin; Animals; Cells, Cultured; Cholesterol; Farnesol; Hydroxycholesterols; Hydroxysteroids; Ketocholesterols; Lipopolysaccharides; Liver X Receptors; Macrophages; Male; Mevalonic Acid; Mice; Mice, Inbred C57BL; Orphan Nuclear Receptors; Receptors, Cytoplasmic and Nuclear; Retinoid X Receptors; Transforming Growth Factor beta; Tretinoin | 2009 |
Differential effects of ibandronate, docetaxel and farnesol treatment alone and in combination on the growth of prostate cancer cell lines.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Survival; Diphosphonates; Docetaxel; Drug Synergism; Farnesol; Humans; Ibandronic Acid; Male; Mevalonic Acid; Prenylation; Prostatic Neoplasms; Signal Transduction; Taxoids | 2011 |
Farnesol production from Escherichia coli by harnessing the exogenous mevalonate pathway.
Topics: Culture Media; Escherichia coli; Farnesol; Gene Dosage; Gene Expression; Geranyltranstransferase; Hemiterpenes; Metabolic Networks and Pathways; Mevalonic Acid; Organophosphorus Compounds; Plasmids; Polyisoprenyl Phosphates; Sesquiterpenes | 2010 |
Effect of farnesol on mevalonate pathway of Staphylococcus aureus.
Topics: Acyl Coenzyme A; Anti-Bacterial Agents; Culture Media; Farnesol; Humans; Mevalonic Acid; Staphylococcus aureus | 2011 |
Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation.
Topics: Alkyl and Aryl Transferases; Animals; Blotting, Western; CA1 Region, Hippocampal; Diterpenes; Electrophysiological Phenomena; Farnesol; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Long-Term Potentiation; Male; Mevalonic Acid; Mice; Mice, Inbred C57BL; Phosphatidylinositol 3-Kinases; Polyisoprenyl Phosphates; Prenylation; Proto-Oncogene Proteins c-akt; Sesquiterpenes; Signal Transduction; Simvastatin | 2012 |
Rosuvastatin inhibits spontaneous and IL-1β-induced interleukin-6 production from human cultured osteoblastic cells.
Topics: Aged; Bone Resorption; Cell Proliferation; Cell Survival; Cells, Cultured; Culture Media; Diterpenes; Farnesol; Femur Head; Fluorobenzenes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Interleukin-1beta; Interleukin-6; Mevalonic Acid; Middle Aged; Osteoblasts; Osteoporosis; Osteoprotegerin; Pyrimidines; RNA, Messenger; Rosuvastatin Calcium; Sulfonamides; Terpenes | 2013 |
Engineered heterologous FPP synthases-mediated Z,E-FPP synthesis in E. coli.
Topics: Bacterial Proteins; Escherichia coli; Farnesol; Geranyltranstransferase; Mevalonic Acid; Mycobacterium tuberculosis; Polyisoprenyl Phosphates; Recombinant Fusion Proteins; Sesquiterpenes | 2013 |
Cardioprotection by farnesol: role of the mevalonate pathway.
Topics: Animals; Animals, Newborn; Cardiotonic Agents; Cell Survival; Cells, Cultured; Cholesterol; Dolichols; Farnesol; Male; Mevalonic Acid; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Protein Prenylation; Rats; Rats, Wistar; Tyrosine; Ubiquinone | 2013 |
Efficient use of exogenous isoprenols for protein isoprenylation by MDA-MB-231 cells is regulated independently of the mevalonate pathway.
Topics: Antineoplastic Agents; Cell Line, Tumor; Diterpenes; Farnesol; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Mutation; Neoplasms; Polyisoprenyl Phosphates; Protein Prenylation; Tumor Suppressor Protein p53 | 2013 |
Zoledronic acid and geranylgeraniol regulate cellular behaviour and angiogenic gene expression in human gingival fibroblasts.
Topics: Adult; Apoptosis; Bone Density Conservation Agents; Bone Morphogenetic Protein 2; Cell Culture Techniques; Cell Survival; Cells, Cultured; Diphosphonates; Diterpenes; Epiregulin; Farnesol; Female; Fibroblasts; Gene Expression Regulation; Gingiva; Humans; Imidazoles; Interferon-alpha; Mevalonic Acid; Microscopy, Electron, Transmission; Middle Aged; Neovascularization, Physiologic; Polyisoprenyl Phosphates; rhoB GTP-Binding Protein; Sesquiterpenes; Signal Transduction; Vascular Endothelial Growth Factor A; Zoledronic Acid | 2014 |
Mevalonates restore zoledronic acid-induced osteoclastogenesis inhibition.
Topics: Acid Phosphatase; Adaptor Proteins, Signal Transducing; Animals; Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone Density Conservation Agents; Bone Remodeling; Calcification, Physiologic; Cathepsin K; Cell Differentiation; Cells, Cultured; Diphosphonates; Diterpenes; Farnesol; Imidazoles; Isoenzymes; Lipopolysaccharides; Macrophages; Male; Maxilla; Membrane Proteins; Mevalonic Acid; Mice; Mice, Inbred C57BL; Osteoclasts; Polyisoprenyl Phosphates; Receptors, Calcitonin; Salmonella; Tartrate-Resistant Acid Phosphatase; Tooth Socket; Vacuolar Proton-Translocating ATPases; Zoledronic Acid | 2015 |
Trans, trans-farnesol as a mevalonate-derived inducer of murine 3T3-F442A pre-adipocyte differentiation.
Topics: Adipocytes; Animals; Blotting, Western; Cell Differentiation; Cell Line; Cell Survival; Farnesol; Gene Expression Profiling; Glucose; Glucose Transporter Type 4; Mevalonic Acid; Mice; PPAR gamma; Real-Time Polymerase Chain Reaction; Triglycerides | 2016 |
Mevalonate-Farnesal Biosynthesis in Ticks: Comparative Synganglion Transcriptomics and a New Perspective.
Topics: Aedes; Amino Acid Sequence; Animals; Biosynthetic Pathways; Cholesterol; Corpora Allata; Farnesol; Female; Geranyltranstransferase; Juvenile Hormones; Male; Methyltransferases; Mevalonic Acid; Mice; Models, Biological; Molecular Sequence Data; NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases; Phylogeny; Sequence Alignment; Ticks; Transcriptome | 2016 |
Farnesol production in Escherichia coli through the construction of a farnesol biosynthesis pathway - application of PgpB and YbjG phosphatases.
Topics: Biosynthetic Pathways; Escherichia coli; Escherichia coli Proteins; Farnesol; Hydrolysis; Membrane Proteins; Mevalonic Acid; Mutagenesis, Site-Directed; Phosphatidate Phosphatase; Polyisoprenyl Phosphates; Recombinant Proteins; Sesquiterpenes; Up-Regulation | 2016 |