farnesol has been researched along with geranylgeraniol in 77 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 34 (44.16) | 18.2507 |
| 2000's | 30 (38.96) | 29.6817 |
| 2010's | 11 (14.29) | 24.3611 |
| 2020's | 2 (2.60) | 2.80 |
| Authors | Studies |
|---|---|
| Franzblau, SG; Inui, T; Jaki, BU; Pauli, GF; Ramos Alvarenga, RF; Wan, B | 1 |
| Baker, BR; Bray, A; Caffrey, M; Cochrane, SA; Ives, CM | 1 |
| Buss, JE; Cox, AD; Der, CJ; Hisaka, MM | 1 |
| Armstrong, J; Fawell, EH; Giannakouros, T; Hancock, JF; Magee, AI; Newman, CM | 1 |
| Gilbert, BA; Pérez-Sala, D; Rando, RR; Tan, EW | 1 |
| Cañada, FJ; Lai, RK; Perez-Sala, D; Rando, RR | 1 |
| Ermolaeva, M; Gautam, N; Kisselev, O | 1 |
| Bernini, F; Corsini, A; Fumagalli, R; Paoletti, R; Raiteri, M; Soma, MR | 1 |
| Andres, DA; Crick, DC; Waechter, CJ | 4 |
| Brenner, DA; Cox, AD; Der, CJ; Garcia, AM; Kowalczyk, JJ; Lewis, MD; Westwick, JK | 1 |
| Lübben, M; Morand, K | 1 |
| Becker, JM; Caldwell, GA; Naider, F; Wang, SH | 1 |
| Corsini, A; Fumagalli, R; Gabbiani, G; Mazzotti, M; Paoletti, R; Raiteri, M; Soma, MR | 1 |
| Doi, T; Koike-Takeshita, A; Koyama, T; Nishino, T; Obata, S; Ogura, K; Sano, H; Tajima, M | 1 |
| Favre, G; Miquel, K; Pradines, A | 1 |
| Hamilton, AD; McGuire, TF; Qian, Y; Sebti, SM; Vogt, A | 2 |
| Katagiri, T; Kizaki, M; Miyazawa, K; Nishimaki, J; Tohyama, K; Toyama, K; Yaguchi, M | 1 |
| Durham, SK; Flint, OP; Gregg, RE; Masters, BA | 1 |
| De Busser, H; Lagrou, A; Van Dessel, G | 1 |
| Ghidoni, JJ; Ghosh, PM; Ghosh-Choudhury, N; Kreisberg, JI; Mott, GE; Radnik, RA; Stapleton, ML | 1 |
| Badimon, L; Llorente-Cortés, V; Martínez-González, J | 1 |
| Andres, DA; Crick, DC; Danesi, R; Macchia, M; Waechter, CJ | 1 |
| Favre, G; Miquel, K; Pradines, A; Selmi, S; Tercé, F | 1 |
| Croucher, PI; Helfrich, MH; Rogers, MJ; Russell, RG; Shipman, CM | 1 |
| Fisher, JE; Halasy, JM; Hughes, DE; Luckman, SP; Masarachia, PJ; Reszka, AA; Rodan, GA; Rogers, MJ; Russell, RG; Wesolowski, G | 1 |
| Auriola, S; Benford, HL; Frith, JC; Mönkkönen, J; Rogers, MJ | 1 |
| Andres, DA; Crick, DC; Finlin, BS; Waechter, CJ | 1 |
| Corsini, A; Farnsworth, CC; Gelb, MH; Glomset, JA; McGeady, P | 1 |
| Foster, BA; Ghosh, PM; Ghosh-Choudhury, N; Greenberg, NM; Kreisberg, JI; Mott, GE; Moyer, ML; Thomas, CA | 1 |
| Andersson, B; Dallner, G; Parmryd, I | 1 |
| Gibbs, BS; Gibbs, RA; Mu, Y; Sebolt-Leopold, JS; Zahn, TJ | 1 |
| Fawcett, TW; Gorospe, M; Holbrook, NJ; Hudgins, WR; Shack, S | 1 |
| Tamanoi, F; Urano, J; Yang, W | 1 |
| Arpaia, M; Banfi, C; Mussoni, L; Sironi, L; Tremoli, E | 1 |
| Clausen, VA; Distefano, MD; Edelstein, RL | 1 |
| Cheng, QF; Rao, PV; Zigler, JS | 1 |
| Corey, EJ; Radetich, B | 1 |
| Hohl, RJ; Ownby, SE | 2 |
| Fushiki, T; Goto, T; Hosokawa, M; Kawada, T; Kimura, K; Matsui, N; Miyashita, K; Saito, M; Taimatsu, A; Takahashi, N; Yamamoto, T | 1 |
| Davis, BA; Lowry, CW; Muir, AQ; Raner, GM | 1 |
| Allen, CM; Barger, J; Chakrabarti, D; Da Silva, T; Paquette, S; Patel, H; Patterson, S | 1 |
| Eisele, F; Ludolph, B; Waldmann, H | 1 |
| Buurman, SW; Frenkel, J; Houten, SM; Kuis, W; Mandey, SH; Rijkers, GT; Wanders, RJ; Waterham, HR | 1 |
| Phipps, RJ; Scutt, A; Still, K | 1 |
| Iguchi, T; Ikeda, Y; Kizaki, M; Miyakawa, Y; Yamamoto, K | 1 |
| Frenkel, J; Houten, SM; Waterham, HR | 1 |
| Mönkkönen, J; Ollikainen, J; Taskinen, M; Töyräs, A | 1 |
| Brown, MS; DeBose-Boyd, RA; Goldstein, JL; Sever, N; Song, BL; Yabe, D | 1 |
| Domínguez, A; Ruiz-Velasco, N; Vega, MA | 1 |
| Doitsidou, M; Farber, SA; Ho, SY; Raz, E; Thorpe, JL | 1 |
| Deng, Y; DeRose, RA; Farber, SA; Ho, SY; Santana, E; Thorpe, JL | 1 |
| Bergh, C; Billig, H; Friberg, PA; Rung, E | 1 |
| Bieler, G; Hasmim, M; Rüegg, C | 1 |
| Kondo, T; Teshima, K | 1 |
| De Leo, L; Decorti, G; Marcuzzi, A; Not, T; Pontillo, A; Tommasini, A; Ventura, A | 1 |
| Au-Yeung, KK; Chan, C; Ko, JK; Lee, SS; Liu, PL; Wu, WY | 1 |
| Muramatsu, M; Obata, S; Ohto, C; Sakuradani, E; Shimizu, S | 2 |
| Head, DD; Kotti, T; McKenna, CE; Russell, DW | 1 |
| Hamashima, H; Inoue, Y; Takano, A; Togashi, N | 1 |
| Alcudia, JF; Badimon, L; Guadall, A; Martínez-González, J; Raposo, B; Rodríguez, C; Sánchez-Gómez, S | 1 |
| Charron, G; Hang, HC; Ivanov, SS; Roy, CR | 1 |
| El-Kabbani, O; Endo, S; Hara, A; Kanamori, A; Kitade, Y; Matsunaga, T; Ohno, S; Ohta, C; Soda, M; Tajima, K | 1 |
| Li, L; Mans, RA; McMahon, LL | 1 |
| Capecchi, PL; Capperucci, C; Ferrata, P; Frediani, B; Galeazzi, M; Laghi-Pasini, F; Lazzerini, PE; Niccolini, S; Spreafico, A | 1 |
| Morris, AJ; Onono, F; Spielmann, HP; Subramanian, KL; Subramanian, T; Sunkara, M | 1 |
| Coates, DE; Cullinan, MP; Drummond, BK; Milne, T; Seymour, GJ; Zafar, S | 1 |
| Hagelauer, N; Pabst, AM; Walter, C; Ziebart, T | 1 |
| Hiroshima, K; Jiang, Y; Kawamura, K; Kobayashi, H; Okamoto, S; Sekine, I; Shimada, H; Shingyoji, M; Tada, Y; Tagawa, M; Takiguchi, Y; Tatsumi, K | 1 |
| Fukushima, S; Minegaki, T; Morioka, C; Nishiguchi, K; Takanashi, H; Tsuji, S; Tsujimoto, M; Uno, J; Watanabe, A; Yamamoto, S | 1 |
| Cheng, HL; Hsieh, MJ; Lin, CW; Lu, KH; Yang, JS; Yang, SF | 1 |
| Crispim, M; Hernández, A; Katzin, AM; Verdaguer, IB | 1 |
6 review(s) available for farnesol and geranylgeraniol
| Article | Year |
|---|---|
Undecaprenol kinase: Function, mechanism and substrate specificity of a potential antibiotic target.
Topics: Anti-Bacterial Agents; Enzyme Inhibitors; Gram-Positive Bacteria; Microbial Sensitivity Tests; Molecular Structure; Phosphotransferases (Alcohol Group Acceptor) | 2021 |
Novel salvage pathway utilizing farnesol and geranylgeraniol for protein isoprenylation.
Topics: Animals; Cell Line; Diterpenes; Farnesol; Mammals; Models, Biological; Protein Prenylation; Sterols | 1997 |
Rapid identification of cysteine-linked isoprenyl groups by metabolic labeling with [3H]farnesol and [3H]geranylgeraniol.
Topics: Animals; Cysteine; Diterpenes; Farnesol; Isotope Labeling; Protein Prenylation; Time Factors; Tritium | 1999 |
Incorporation of radiolabeled prenyl alcohols and their analogs into mammalian cell proteins. A useful tool for studying protein prenylation.
Topics: Animals; Diterpenes; Farnesol; Hemiterpenes; Isotope Labeling; Pentanols; Protein Prenylation | 1999 |
Isoprenoid biosynthesis in hereditary periodic fever syndromes and inflammation.
Topics: Cholesterol; Diterpenes; Familial Mediterranean Fever; Farnesol; Humans; Inflammation; Mevalonic Acid; Models, Biological; Mutation; Phosphotransferases (Alcohol Group Acceptor); Polyisoprenyl Phosphates; Syndrome | 2003 |
The Biomedical Importance of the Missing Pathway for Farnesol and Geranylgeraniol Salvage.
Topics: Animals; Diterpenes; Farnesol; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Terpenes | 2022 |
71 other study(ies) available for farnesol and geranylgeraniol
| Article | Year |
|---|---|
Airborne antituberculosis activity of Eucalyptus citriodora essential oil.
Topics: Acyclic Monoterpenes; Antitubercular Agents; Cyclohexane Monoterpenes; Cyclohexanols; Cyclohexenes; Databases, Factual; Eucalyptol; Eucalyptus; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Molecular Structure; Monoterpenes; Oils, Volatile; Plant Leaves; Sesquiterpenes, Eudesmane; Tuberculosis; Tuberculosis, Multidrug-Resistant | 2014 |
Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Cell Division; Cell Membrane; Cell Transformation, Neoplastic; Cysteine; Diterpenes; Farnesol; GTP-Binding Proteins; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras); Proto-Oncogene Proteins pp60(c-src); rap GTP-Binding Proteins; Structure-Activity Relationship | 1992 |
Post-translational processing of Schizosaccharomyces pombe YPT proteins.
Topics: Amino Acid Sequence; Chromatography, High Pressure Liquid; Diterpenes; DNA; Electrophoresis, Polyacrylamide Gel; Farnesol; Fungal Proteins; GTP-Binding Proteins; Hydroxylamine; Hydroxylamines; Methylation; Mevalonic Acid; Molecular Sequence Data; Oncogene Protein p21(ras); Protein Biosynthesis; Protein Processing, Post-Translational; rab GTP-Binding Proteins; Saccharomyces cerevisiae Proteins; Schizosaccharomyces | 1992 |
Prenylated protein methyltransferases do not distinguish between farnesylated and geranylgeranylated substrates.
Topics: Alkyl and Aryl Transferases; Animals; Cattle; Diterpenes; Farnesol; Kinetics; Methylation; Protein Methyltransferases; Protein Processing, Post-Translational; Rod Cell Outer Segment; Substrate Specificity; Transferases | 1992 |
The gamma subunit of transducin is farnesylated.
Topics: Animals; Cattle; Diterpenes; Farnesol; Gas Chromatography-Mass Spectrometry; In Vitro Techniques; Leucine; Macromolecular Substances; Mevalonic Acid; Protein Processing, Post-Translational; Retina; Transducin | 1990 |
Efficient interaction with a receptor requires a specific type of prenyl group on the G protein gamma subunit.
Topics: Acyclic Monoterpenes; Amino Acid Sequence; Diterpenes; Farnesol; GTP-Binding Proteins; Molecular Sequence Data; Peptide Fragments; Protein Prenylation; Receptors, Cell Surface; Rhodopsin; Rod Opsins; Terpenes | 1995 |
Pathogenesis of atherosclerosis and the role of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors.
Topics: Animals; Anticholesteremic Agents; Arteriosclerosis; Cell Division; Cell Movement; Cells, Cultured; Cholesterol Esters; Diterpenes; Farnesol; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Macrophages, Peritoneal; Male; Mevalonic Acid; Mice; Mice, Inbred BALB C; Muscle, Smooth, Vascular; Pravastatin; Rabbits; Rats; Rats, Sprague-Dawley; Simvastatin | 1995 |
Farnesol is utilized for protein isoprenylation and the biosynthesis of cholesterol in mammalian cells.
Topics: Animals; Cell Line; Chlorocebus aethiops; Cholesterol; Cysteine; Diterpenes; Electrophoresis, Polyacrylamide Gel; Farnesol; Glioma; Kinetics; Mevalonic Acid; Neoplasm Proteins; Protein Biosynthesis; Protein Prenylation; Proteins; Rats; Tritium; Tumor Cells, Cultured; Ubiquinone | 1995 |
The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation.
Topics: 3T3 Cells; Animals; Cell Transformation, Neoplastic; Diterpenes; DNA-Binding Proteins; ets-Domain Protein Elk-1; Farnesol; Mice; Myristic Acid; Myristic Acids; Oligopeptides; Oncogene Protein p21(ras); Protein Prenylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-jun; Retroviridae Proteins, Oncogenic; Signal Transduction; Transcription Factors; Transcription, Genetic | 1994 |
Novel prenylated hemes as cofactors of cytochrome oxidases. Archaea have modified hemes A and O.
Topics: Archaea; Bacteria; Chromatography, High Pressure Liquid; Diterpenes; Electron Transport Complex IV; Farnesol; Heme; Mass Spectrometry; Membranes; Spectrophotometry; Sulfolobus acidocaldarius; Terpenes; Thermoplasma | 1994 |
Consequences of altered isoprenylation targets on a-factor export and bioactivity.
Topics: Amino Acid Sequence; ATP-Binding Cassette Transporters; Biological Transport; Dimethylallyltranstransferase; Diterpenes; Farnesol; Fungal Proteins; Glycoproteins; Mating Factor; Molecular Sequence Data; Mutagenesis; Oligopeptides; Peptides; Protein Prenylation; Regulatory Sequences, Nucleic Acid; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Substrate Specificity | 1994 |
Relationship between mevalonate pathway and arterial myocyte proliferation: in vitro studies with inhibitors of HMG-CoA reductase.
Topics: Acyclic Monoterpenes; Animals; Aorta; Cell Division; Cells, Cultured; Cholesterol; Diterpenes; Dose-Response Relationship, Drug; Farnesol; Fatty Acids, Monounsaturated; Femoral Artery; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Male; Mevalonic Acid; Muscle, Smooth, Vascular; Pravastatin; Rats; Rats, Sprague-Dawley; Simvastatin; Squalene; Terpenes | 1993 |
Geranylgeraniol restores cell proliferation to lovastatin treated C6 glial cells.
Topics: Animals; Cell Division; Cell Line; Diterpenes; Enzyme Inhibitors; Farnesol; Haplorhini; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney; Lovastatin; Neuroglia; Rats | 1996 |
Identification of significant residues in the substrate binding site of Bacillus stearothermophilus farnesyl diphosphate synthase.
Topics: Acyclic Monoterpenes; Alkyl and Aryl Transferases; Amino Acid Sequence; Base Sequence; Binding Sites; Chromatography, Thin Layer; Conserved Sequence; Diterpenes; Farnesol; Geobacillus stearothermophilus; Geranyltranstransferase; Hemiterpenes; Indoles; Kinetics; Models, Chemical; Molecular Sequence Data; Molecular Structure; Mutagenesis, Site-Directed; Organophosphorus Compounds; Sequence Alignment; Terpenes; Transferases | 1996 |
Farnesol and geranylgeraniol induce actin cytoskeleton disorganization and apoptosis in A549 lung adenocarcinoma cells.
Topics: Actins; Acyclic Monoterpenes; Apoptosis; Cholesterol; Cytoskeleton; Desmosterol; Diterpenes; Enzyme Inhibitors; Farnesol; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Squalene; Terpenes; Tumor Cells, Cultured | 1996 |
Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation.
Topics: 3T3 Cells; Alkyl and Aryl Transferases; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Diterpenes; Enzyme Inhibitors; Farnesol; Farnesyltranstransferase; Kinetics; Lovastatin; Methionine; Mice; Phosphorylation; Phosphotyrosine; Protein Prenylation; Receptors, Platelet-Derived Growth Factor; Recombinant Proteins; Structure-Activity Relationship; Transfection; Transferases | 1996 |
Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts.
Topics: Actins; Alkyl and Aryl Transferases; Animals; Benzamides; Cell Cycle; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Cytoskeleton; Diterpenes; DNA; Enzyme Inhibitors; Farnesol; Fibroblasts; G1 Phase; Genes, ras; GTP-Binding Proteins; Lovastatin; Methionine; Mevalonic Acid; Mice; Protein Prenylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; rap GTP-Binding Proteins; ras Proteins; Resting Phase, Cell Cycle; S Phase; Transferases | 1996 |
Geranylgeraniol promotes entry of UT-2 cells into the cell cycle in the absence of mevalonate.
Topics: Animals; Cell Cycle; CHO Cells; Cricetinae; Cricetulus; Diterpenes; Farnesol; Hydroxymethylglutaryl CoA Reductases; Mevalonic Acid; Protein Prenylation; Protein Processing, Post-Translational; S Phase | 1997 |
Vitamin K2 and its derivatives induce apoptosis in leukemia cells and enhance the effect of all-trans retinoic acid.
Topics: Apoptosis; Bone Marrow; Diterpenes; Drug Synergism; Farnesol; Flow Cytometry; Gefarnate; Humans; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid; Leukemia, Promyelocytic, Acute; Molecular Structure; Myelodysplastic Syndromes; Structure-Activity Relationship; Tretinoin; Tumor Cells, Cultured; Vitamin K; Vitamin K 1; Vitamin K 2 | 1997 |
Inhibition of cholesterol synthesis by squalene synthase inhibitors does not induce myotoxicity in vitro.
Topics: Analysis of Variance; Animals; Animals, Newborn; Anticholesteremic Agents; Butylamines; Cells, Cultured; Cholesterol; Diterpenes; Enzyme Inhibitors; Farnesol; Farnesyl-Diphosphate Farnesyltransferase; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; L-Lactate Dehydrogenase; Lovastatin; Mevalonic Acid; Muscle, Skeletal; Pravastatin; Pregnancy; Prodrugs; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Squalene; Sulfonic Acids | 1997 |
Internalisation of short-chain isoprenyl diphosphates by chromaffin cells from bovine adrenal medulla.
Topics: Adrenal Medulla; Amino Acids; Animals; Cations; Cattle; Cells, Cultured; Chromaffin Cells; Diterpenes; Energy Metabolism; Farnesol; Kinetics; Polyisoprenyl Phosphates; Subcellular Fractions; Tritium | 1997 |
Lovastatin induces apoptosis by inhibiting mitotic and post-mitotic events in cultured mesangial cells.
Topics: Actins; Animals; Apoptosis; Bromodeoxyuridine; Cell Count; Cell Division; Cell Movement; Cell Size; Cells, Cultured; Diterpenes; Farnesol; Glomerular Mesangium; GTP-Binding Proteins; Lovastatin; Microscopy, Electron; Microscopy, Video; Mitosis; Protein Prenylation; Rats; rhoA GTP-Binding Protein | 1997 |
Esterified cholesterol accumulation induced by aggregated LDL uptake in human vascular smooth muscle cells is reduced by HMG-CoA reductase inhibitors.
Topics: Cells, Cultured; Cholesterol; Diterpenes; Esterification; Farnesol; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Lipoproteins, LDL; Muscle, Smooth, Vascular; Simvastatin | 1998 |
Geranylgeraniol overcomes the block of cell proliferation by lovastatin in C6 glioma cells.
Topics: Animals; Cell Division; Diterpenes; Electrophoresis, Polyacrylamide Gel; Farnesol; Glioma; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Molecular Weight; Nerve Tissue Proteins; Polyisoprenyl Phosphates; Protein Prenylation; Rats; Thymidine; Tumor Cells, Cultured | 1998 |
Competitive inhibition of choline phosphotransferase by geranylgeraniol and farnesol inhibits phosphatidylcholine synthesis and induces apoptosis in human lung adenocarcinoma A549 cells.
Topics: Actins; Apoptosis; Binding, Competitive; Cell Division; Choline; Choline-Phosphate Cytidylyltransferase; Cytidine Diphosphate Choline; Cytoskeleton; Diacylglycerol Cholinephosphotransferase; Diglycerides; Diterpenes; Enzyme Inhibitors; Farnesol; Humans; Interphase; Microscopy, Fluorescence; Microsomes; Phosphatidylcholines; Protein Prenylation; Tumor Cells, Cultured | 1998 |
The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Division; Diphosphonates; Diterpenes; Enzyme Inhibitors; Farnesol; Humans; Lovastatin; Mevalonic Acid; Multiple Myeloma; Protein Prenylation; Tumor Cells, Cultured | 1998 |
Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro.
Topics: Alendronate; Animals; Bone Resorption; Cell Differentiation; Cells, Cultured; Cholesterol; Clodronic Acid; Diterpenes; Enzyme Activation; Farnesol; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Mice; Osteoclasts; Protein Kinases; Rabbits; Skull; Squalene | 1999 |
Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates: biochemical evidence for two distinct pharmacological classes of bisphosphonate drugs.
Topics: Adenosine Triphosphate; Alendronate; Animals; Apoptosis; Caspase 3; Caspase Inhibitors; Cells, Cultured; Diphosphonates; Diterpenes; Endopeptidases; Enzyme Activation; Farnesol; Mice; Protein Prenylation | 1999 |
Role of RhoA activation in the growth and morphology of a murine prostate tumor cell line.
Topics: Actin Cytoskeleton; Adenocarcinoma; Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Apoptosis; Cell Adhesion; Cell Division; Cell Size; Diterpenes; Drug Interactions; Enzyme Activation; Farnesol; G1 Phase; Genes, ras; GTP-Binding Proteins; Guanosine Triphosphate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Mevalonic Acid; Mice; Mice, Transgenic; Polyisoprenyl Phosphates; Prostatic Neoplasms; Protein Prenylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras); rac GTP-Binding Proteins; rhoA GTP-Binding Protein; Sesquiterpenes; Tumor Cells, Cultured | 1999 |
Protein prenylation in spinach chloroplasts.
Topics: Animals; Cell Fractionation; Chloroplasts; Cotyledon; Diterpenes; Farnesol; Gas Chromatography-Mass Spectrometry; Mammals; Mevalonic Acid; Plant Proteins; Protein Prenylation; Protein Synthesis Inhibitors; Spinacia oleracea; Tritium | 1999 |
Novel farnesol and geranylgeraniol analogues: A potential new class of anticancer agents directed against protein prenylation.
Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Catalysis; Diterpenes; Electrophoresis, Polyacrylamide Gel; Farnesol; Kinetics; Models, Chemical; Protein Prenylation; Tumor Cells, Cultured | 1999 |
Activation of the cholesterol pathway and Ras maturation in response to stress.
Topics: Adenocarcinoma; Calcium-Calmodulin-Dependent Protein Kinases; Cholesterol; Diterpenes; Farnesol; Genes, ras; Heat-Shock Response; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Lovastatin; Male; Mevalonic Acid; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Prostatic Neoplasms; Protein Prenylation; ras Proteins; Sterols; Stress, Physiological | 1999 |
Protein farnesylation is critical for maintaining normal cell morphology and canavanine resistance in Schizosaccharomyces pombe.
Topics: Alkyl and Aryl Transferases; Amino Acid Sequence; Arginine; Biological Transport; Canavanine; Cell Differentiation; Diterpenes; Drug Resistance; Farnesol; Farnesyltranstransferase; Fungal Proteins; Molecular Sequence Data; Mutation; Phenotype; Protein Prenylation; ras Proteins; rho GTP-Binding Proteins; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Sequence Homology, Amino Acid; Substrate Specificity | 2000 |
Fluvastatin inhibits basal and stimulated plasminogen activator inhibitor 1, but induces tissue type plasminogen activator in cultured human endothelial cells.
Topics: Cells, Cultured; Depression, Chemical; Diterpenes; Endothelium, Vascular; Farnesol; Fatty Acids, Monounsaturated; Fluvastatin; Gene Expression Regulation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lipopolysaccharides; Mevalonic Acid; Plasminogen Activator Inhibitor 1; RNA, Messenger; Tetradecanoylphorbol Acetate; Tissue Plasminogen Activator; Tumor Necrosis Factor-alpha; Umbilical Veins | 2000 |
Stereochemical analysis of the reaction catalyzed by human protein geranylgeranyl transferase.
Topics: Alkyl and Aryl Transferases; Catalysis; Dansyl Compounds; Deuterium; Dipeptides; Diterpenes; Farnesol; Humans; Nuclear Magnetic Resonance, Biomolecular; Oligopeptides; Protein Prenylation; Stereoisomerism; Substrate Specificity | 2001 |
Effect of perillic acid, a putative isoprenylation inhibitor, on the cultured rat lens.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cataract; Cyclohexenes; Diterpenes; Dose-Response Relationship, Drug; Farnesol; Female; GTP Phosphohydrolases; Lens, Crystalline; Lovastatin; Male; Monoterpenes; Organ Culture Techniques; Protein Prenylation; Rats; Rats, Sprague-Dawley; Terpenes | 2001 |
A general stereocontrolled, convergent synthesis of oligoprenols that parallels the biosynthetic pathway.
Topics: Acyclic Monoterpenes; Diterpenes; Farnesol; Hemiterpenes; Pentanols; Stereoisomerism; Terpenes | 2002 |
Farnesol and geranylgeraniol: prevention and reversion of lovastatin-induced effects in NIH3T3 cells.
Topics: 3T3 Cells; Animals; Anticholesteremic Agents; Diterpenes; Farnesol; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mice; Protein Prenylation | 2002 |
Dual action of isoprenols from herbal medicines on both PPARgamma and PPARalpha in 3T3-L1 adipocytes and HepG2 hepatocytes.
Topics: 3T3 Cells; Adipocytes; Animals; Carotenoids; Cell Line; CREB-Binding Protein; Diterpenes; Dose-Response Relationship, Drug; Farnesol; Genes, Reporter; Hepatocytes; Humans; Ligands; Mice; Nuclear Proteins; Oleic Acid; Plant Preparations; Polymerase Chain Reaction; Receptors, Cytoplasmic and Nuclear; Terpenes; Trans-Activators; Transcription Factors; Transfection; Up-Regulation | 2002 |
Farnesol as an inhibitor and substrate for rabbit liver microsomal P450 enzymes.
Topics: Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diterpenes; Enzyme Inhibitors; Farnesol; Isoenzymes; Kinetics; Microsomes, Liver; Rabbits; Recombinant Proteins; Substrate Specificity | 2002 |
Protein farnesyltransferase and protein prenylation in Plasmodium falciparum.
Topics: Alkyl and Aryl Transferases; Animals; Antimalarials; Diterpenes; Enzyme Inhibitors; Farnesol; Farnesyltranstransferase; Plasmodium falciparum; Protein Prenylation; Protozoan Proteins; Substrate Specificity | 2002 |
Solution- and solid-phase synthesis of the polybasic lipid-modified C termini of Rho A and K-Ras 4B.
Topics: Diterpenes; Farnesol; Humans; Lipids; Peptides; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins; rhoA GTP-Binding Protein | 2002 |
Lack of isoprenoid products raises ex vivo interleukin-1beta secretion in hyperimmunoglobulinemia D and periodic fever syndrome.
Topics: Antibodies; CD2 Antigens; CD28 Antigens; Cell Division; Cells, Cultured; Child; Diterpenes; Familial Mediterranean Fever; Farnesol; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypergammaglobulinemia; Immunoglobulin D; Interleukin-1; Lovastatin; Male; Mevalonic Acid; Phosphotransferases (Alcohol Group Acceptor); Polyisoprenyl Phosphates; T-Lymphocytes | 2002 |
Effects of risedronate, alendronate, and etidronate on the viability and activity of rat bone marrow stromal cells in vitro.
Topics: Alendronate; Animals; Bone and Bones; Bone Marrow Cells; Cell Survival; Diphosphonates; Diterpenes; Etidronic Acid; Farnesol; Fibroblasts; Models, Animal; Rats; Rats, Wistar; Risedronic Acid; Stromal Cells | 2003 |
Nitrogen-containing bisphosphonates induce S-phase cell cycle arrest and apoptosis of myeloma cells by activating MAPK pathway and inhibiting mevalonate pathway.
Topics: Apoptosis; Cell Division; Cell Line, Tumor; Checkpoint Kinase 1; Diphosphonates; Diterpenes; Enzyme Inhibitors; Farnesol; Humans; Imidazoles; Interleukin-6; MAP Kinase Signaling System; Mevalonic Acid; Multiple Myeloma; Phosphorylation; Protein Kinases; S Phase; Signal Transduction; Stromal Cells | 2003 |
Inhibition of mevalonate pathway is involved in alendronate-induced cell growth inhibition, but not in cytokine secretion from macrophages in vitro.
Topics: Alendronate; Animals; Cell Division; Cell Line; Diterpenes; Farnesol; Lipopolysaccharides; Macrophages; Mevalonic Acid; Mice | 2003 |
Isoprenoid alcohols restore protein isoprenylation in a time-dependent manner independent of protein synthesis.
Topics: Alcohols; Animals; Cycloheximide; Diterpenes; Farnesol; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Lovastatin; Mice; Monomeric GTP-Binding Proteins; NIH 3T3 Cells; Protein Biosynthesis; Protein Prenylation; Protein Synthesis Inhibitors; ras Proteins; Terpenes | 2003 |
Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol.
Topics: Alanine; Amino Acid Sequence; Animals; Carrier Proteins; Cell Membrane; CHO Cells; Cricetinae; Diterpenes; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Farnesol; Hydroxymethylglutaryl CoA Reductases; Immunoblotting; Intracellular Signaling Peptides and Proteins; Lysine; Membrane Proteins; Mevalonic Acid; Molecular Sequence Data; Peptides; Plasmids; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Sequence Homology, Amino Acid; Sterols; Subcellular Fractions; Time Factors; Transfection; Ubiquitin | 2003 |
Statins upregulate CD36 expression in human monocytes, an effect strengthened when combined with PPAR-gamma ligands Putative contribution of Rho GTPases in statin-induced CD36 expression.
Topics: Actins; Anticholesteremic Agents; CD36 Antigens; Cells, Cultured; Cytoskeleton; Diterpenes; Farnesol; Gene Expression Regulation; Humans; Lipoproteins, LDL; Lovastatin; Mevalonic Acid; Monocytes; Receptors, Cytoplasmic and Nuclear; rho GTP-Binding Proteins; RNA, Messenger; Transcription Factors; Transcription, Genetic | 2004 |
Germ cell migration in zebrafish is dependent on HMGCoA reductase activity and prenylation.
Topics: Animals; Anticholesteremic Agents; Atorvastatin; Cell Movement; Chemokine CXCL12; Chemokines, CXC; Diterpenes; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Nonmammalian; Enzyme Inhibitors; Farnesol; gamma-Glutamyltransferase; Germ Cells; Heptanoic Acids; Hydroxymethylglutaryl CoA Reductases; Mevalonic Acid; Microinjections; Morpholines; Protein Prenylation; Pyrroles; RNA-Binding Proteins; RNA, Messenger; Somites; Time Factors; Zebrafish; Zebrafish Proteins | 2004 |
Lipid metabolism in zebrafish.
Topics: 4-Chloro-7-nitrobenzofurazan; Alkyl and Aryl Transferases; Animals; Annexin A2; Atorvastatin; Azetidines; Boron Compounds; Caveolin 1; Caveolins; Cell Movement; Cholesterol; Diterpenes; DNA; Embryo, Nonmammalian; Ethylnitrosourea; Ezetimibe; Farnesol; Farnesyltranstransferase; Geranyltranstransferase; Germ Cells; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Metabolism; Lipids; Lovastatin; Mevalonic Acid; Microscopy, Fluorescence; Mutagenesis, Site-Directed; Mutation; Phosphatidylethanolamines; Protein Binding; Protein Prenylation; Pyrroles; Simvastatin; Zebrafish | 2004 |
Depletion of substrates for protein prenylation increases apoptosis in human periovulatory granulosa cells.
Topics: Apoptosis; Cells, Cultured; Cholesterol; Diterpenes; Estrenes; Farnesol; Farnesyltranstransferase; Female; Furans; Granulosa Cells; Hormone Antagonists; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazoles; Leucine; Mifepristone; Ovulation; Protein Prenylation; Quinolones; Receptors, Progesterone | 2006 |
Zoledronate inhibits endothelial cell adhesion, migration and survival through the suppression of multiple, prenylation-dependent signaling pathways.
Topics: Angiogenesis Inhibitors; Bone Density Conservation Agents; Cell Adhesion; Cell Movement; Cell Survival; Cells, Cultured; Diphosphonates; Diterpenes; Endothelial Cells; Extracellular Signal-Regulated MAP Kinases; Farnesol; Focal Adhesion Kinase 1; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; Phosphorylation; Protein Kinase Inhibitors; Protein Prenylation; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins c-akt; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Tumor Necrosis Factor-alpha; Umbilical Veins; Zoledronic Acid | 2007 |
Analytical method for determination of allylic isoprenols in rat tissues by liquid chromatography/tandem mass spectrometry following chemical derivatization with 3-nitrophtalic anhydride.
Topics: Animals; Chromatography, High Pressure Liquid; Diterpenes; Farnesol; Liver; Male; Phthalic Anhydrides; Rats; Tandem Mass Spectrometry; Testis | 2008 |
Natural isoprenoids are able to reduce inflammation in a mouse model of mevalonate kinase deficiency.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Acyclic Monoterpenes; Alendronate; Animals; Disease Models, Animal; Diterpenes; Farnesol; Inflammation; Male; Mevalonate Kinase Deficiency; Mice; Mice, Inbred BALB C; Terpenes | 2008 |
Herbal isoprenols induce apoptosis in human colon cancer cells through transcriptional activation of PPARgamma.
Topics: Anilides; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-X Protein; Caspase 3; Cell Proliferation; Cell Survival; Colonic Neoplasms; Diterpenes; Dose-Response Relationship, Drug; Enzyme Activation; Farnesol; Gene Expression Regulation, Neoplastic; HCT116 Cells; HT29 Cells; Humans; Inhibitor of Apoptosis Proteins; Microtubule-Associated Proteins; Neoplasm Proteins; Poly(ADP-ribose) Polymerases; PPAR gamma; Promoter Regions, Genetic; Survivin; Time Factors; Transcriptional Activation | 2008 |
Accumulation of prenyl alcohols by terpenoid biosynthesis inhibitors in various microorganisms.
Topics: Alkyl and Aryl Transferases; Biosynthetic Pathways; Diphenylamine; Diterpenes; Enzyme Inhibitors; Farnesol; Farnesyl-Diphosphate Farnesyltransferase; Fungi; Terpenes | 2008 |
Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation.
Topics: Alkyl and Aryl Transferases; Animals; Apolipoproteins E; Cholesterol; Cholesterol 24-Hydroxylase; Dendrites; Disease Models, Animal; Diterpenes; Farnesol; Hippocampus; Hyperlipoproteinemia Type III; Learning; Long-Term Potentiation; Mevalonic Acid; Mice; Mice, Knockout; Prenylation; Steroid Hydroxylases; Time Factors; Transferases | 2008 |
Effects of two terpene alcohols on the antibacterial activity and the mode of action of farnesol against Staphylococcus aureus.
Topics: Acyclic Monoterpenes; Anti-Bacterial Agents; Cell Membrane; Diterpenes; Farnesol; Microbial Sensitivity Tests; Potassium; Staphylococcus aureus; Terpenes | 2008 |
Prenyl alcohol production by expression of exogenous isopentenyl diphosphate isomerase and farnesyl diphosphate synthase genes in Escherichia coli.
Topics: Carbon-Carbon Double Bond Isomerases; Diterpenes; Escherichia coli; Escherichia coli Proteins; Farnesol; Geranyltranstransferase; Hemiterpenes | 2009 |
Statins normalize vascular lysyl oxidase down-regulation induced by proatherogenic risk factors.
Topics: Animals; Atherosclerosis; Atorvastatin; Capillary Permeability; Cattle; Cells, Cultured; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Down-Regulation; Endothelial Cells; Farnesol; Female; Gene Expression Regulation, Enzymologic; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipoproteins, LDL; Protein Kinase C; Protein Kinase Inhibitors; Protein-Lysine 6-Oxidase; Pyrroles; rho-Associated Kinases; rhoA GTP-Binding Protein; Risk Factors; RNA, Messenger; Simvastatin; Swine; Transfection; Tumor Necrosis Factor-alpha | 2009 |
Lipidation by the host prenyltransferase machinery facilitates membrane localization of Legionella pneumophila effector proteins.
Topics: Alkyl and Aryl Transferases; Amino Acid Motifs; Animals; Bacterial Proteins; Chlorocebus aethiops; COS Cells; Dimethylallyltranstransferase; Diterpenes; Farnesol; Farnesyltranstransferase; HeLa Cells; Host-Pathogen Interactions; Humans; Legionella pneumophila; Legionnaires' Disease; Mice; Protein Prenylation | 2010 |
Roles of rat and human aldo-keto reductases in metabolism of farnesol and geranylgeraniol.
Topics: Aldehydes; Animals; Cell Line; Cytosol; Diterpenes; Farnesol; Humans; Microsomes; Oxidoreductases; Rats; Terpenes | 2011 |
Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation.
Topics: Alkyl and Aryl Transferases; Animals; Blotting, Western; CA1 Region, Hippocampal; Diterpenes; Electrophysiological Phenomena; Farnesol; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Long-Term Potentiation; Male; Mevalonic Acid; Mice; Mice, Inbred C57BL; Phosphatidylinositol 3-Kinases; Polyisoprenyl Phosphates; Prenylation; Proto-Oncogene Proteins c-akt; Sesquiterpenes; Signal Transduction; Simvastatin | 2012 |
Rosuvastatin inhibits spontaneous and IL-1β-induced interleukin-6 production from human cultured osteoblastic cells.
Topics: Aged; Bone Resorption; Cell Proliferation; Cell Survival; Cells, Cultured; Culture Media; Diterpenes; Farnesol; Femur Head; Fluorobenzenes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Interleukin-1beta; Interleukin-6; Mevalonic Acid; Middle Aged; Osteoblasts; Osteoporosis; Osteoprotegerin; Pyrimidines; RNA, Messenger; Rosuvastatin Calcium; Sulfonamides; Terpenes | 2013 |
Efficient use of exogenous isoprenols for protein isoprenylation by MDA-MB-231 cells is regulated independently of the mevalonate pathway.
Topics: Antineoplastic Agents; Cell Line, Tumor; Diterpenes; Farnesol; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Mutation; Neoplasms; Polyisoprenyl Phosphates; Protein Prenylation; Tumor Suppressor Protein p53 | 2013 |
Zoledronic acid and geranylgeraniol regulate cellular behaviour and angiogenic gene expression in human gingival fibroblasts.
Topics: Adult; Apoptosis; Bone Density Conservation Agents; Bone Morphogenetic Protein 2; Cell Culture Techniques; Cell Survival; Cells, Cultured; Diphosphonates; Diterpenes; Epiregulin; Farnesol; Female; Fibroblasts; Gene Expression Regulation; Gingiva; Humans; Imidazoles; Interferon-alpha; Mevalonic Acid; Microscopy, Electron, Transmission; Middle Aged; Neovascularization, Physiologic; Polyisoprenyl Phosphates; rhoB GTP-Binding Protein; Sesquiterpenes; Signal Transduction; Vascular Endothelial Growth Factor A; Zoledronic Acid | 2014 |
Bisphosphonates inhibit cell functions of HUVECs, fibroblasts and osteogenic cells via inhibition of protein geranylgeranylation.
Topics: Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone Density Conservation Agents; Cell Movement; Cell Survival; Cells, Cultured; Cyclohexenes; Diphosphonates; Diterpenes; Endothelial Cells; Eugenol; Farnesol; Fibroblasts; Humans; Imidazoles; Limonene; Menthol; Osteogenesis; Protein Prenylation; Recurrence; Squalene; Terpenes; Umbilical Veins; Zoledronic Acid | 2015 |
Zoledronic acid induces apoptosis and S-phase arrest in mesothelioma through inhibiting Rab family proteins and topoisomerase II actions.
Topics: Apoptosis; cdc42 GTP-Binding Protein; Cell Line, Tumor; Diphosphonates; Diterpenes; DNA Topoisomerases, Type II; Farnesol; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Leucine; Mesothelioma; Myeloid Cell Leukemia Sequence 1 Protein; Protein Prenylation; rab GTP-Binding Proteins; rac1 GTP-Binding Protein; rhoA GTP-Binding Protein; RNA, Small Interfering; S Phase; Signal Transduction; Transferases; Zoledronic Acid | 2014 |
Effects of bisphosphonates on human esophageal squamous cell carcinoma cell survival.
Topics: Annexins; Apoptosis; Bone Density Conservation Agents; Carcinoma, Squamous Cell; Caspase 3; Caspase 7; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Cyclin D1; Diphosphonates; Diterpenes; Drug Screening Assays, Antitumor; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Farnesol; G1 Phase Cell Cycle Checkpoints; Humans; Squalene | 2016 |
Zoledronate blocks geranylgeranylation not farnesylation to suppress human osteosarcoma U2OS cells metastasis by EMT via Rho A activation and FAK-inhibited JNK and p38 pathways.
Topics: Biological Transport; Bone Density Conservation Agents; Bone Neoplasms; Cadherins; cdc42 GTP-Binding Protein; Cell Line, Tumor; Cell Movement; Cell Survival; Diphosphonates; Diterpenes; Epithelial-Mesenchymal Transition; Farnesol; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Neoplasm Invasiveness; Nuclear Proteins; Osteoporosis; Osteosarcoma; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Prenylation; Proto-Oncogene Proteins pp60(c-src); rho-Associated Kinases; Snail Family Transcription Factors; Twist-Related Protein 1; Zoledronic Acid | 2016 |