famotidine has been researched along with indomethacin in 54 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (14.81) | 18.2507 |
| 2000's | 21 (38.89) | 29.6817 |
| 2010's | 19 (35.19) | 24.3611 |
| 2020's | 6 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Kodama, H; Kuratani, K; Yamaguchi, I; Yamazaki, M | 1 |
| Aihara, H; Isobe, Y; Muramatsu, M; Nagai, H; Otomo, S | 1 |
| Kuratani, K; Maeda, N; Nomura, K; Yamaguchi, I | 1 |
| Akuzawa, S; Ito, H; Kamato, T; Kobayashi, A; Miyata, K; Nagakura, Y; Nishida, A; Takinami, Y; Yamano, M; Yuki, H | 1 |
| Khoo, NK; Lala, PK; Saarloos, MN | 1 |
| Asano, S; Inatomi, N; Murakami, I; Nagaya, H; Satoh, H; Yukishige, K | 1 |
| Conejo, L; Ortiz, JA; Palop, D; Romero, A; Sacristán, A; Villamayor, F | 1 |
| Aoyama, M; Arai, Y; Inaba, N; Nishizawa, A; Onodera, S; Sekine, Y; Shibata, M; Suzuki, T; Tanaka, M | 1 |
| Borrelli, F; Tavares, IA; Welsh, NJ | 1 |
| Akcay, MF; Banoglu, ZN; Büyükokuroglu, ME; Demirezer, LO; Gepdiremen, A; Göçer, F; Süleyman, H | 1 |
| Arceiz Gonzalo, E; Lanas Arbeloa, A; Ortego Díez De Retana, J; Pérez Aisa, A; Sainz Samitier, R; Sopeña Biarge, F | 1 |
| Borrelli, F; Tavares, IA | 1 |
| Ahrens, F; Aschenbach, JR; Gäbel, G | 1 |
| Arceiz, E; Lanas, A; Ortego, J; Pérez-Aisa, A; Sainz, R; Sopeña, F | 1 |
| Gürsan, N; Ozbakiş Dengiz, G | 1 |
| Harada, N; Okajima, K | 1 |
| Agashe, HB; Gupta, U; Jain, NK | 1 |
| Cadirci, E; Dengiz, GO; Halici, Z; Odabasoglu, F; Suleyman, H | 1 |
| Hasumura, M; Hirose, M; Imai, T; Onose, J; Ozeki, Y; Ueda, M | 1 |
| Albayrak, F; Bilici, M; Dursun, H; Gulaboglu, M; Ozturk, C; Saglam, MB; Tekin, SB; Uyanik, A | 1 |
| Antonioli, L; Blandizzi, C; Colucci, R; Del Tacca, M; Fornai, M; Ghisu, N; Tuccori, M | 1 |
| Albayrak, A; Bayir, Y; Cadirci, E; Hacimuftuoglu, A; Halici, Z; Koc, F; Polat, B; Suleyman, H | 1 |
| Bektas, S; Can, M; Comert, M; Emre, AU; Hanci, V; Irkorucu, O; Karadeniz Cakmak, G; Karakaya, K; Ozkocak Turan, I; Tascilar, O; Ucan, HB | 1 |
| Higuchi, K; Murano, M; Tokioka, S; Umegaki, E; Yoda, Y | 1 |
| Albayrak, F; Albayrak, Y; Bayir, Y; Dursun, H; Halici, Z; Koc, F; Odabasoglu, F; Polat, B; Suleyman, H; Uyanik, A | 1 |
| Antonioli, L; Awwad, O; Basolo, F; Blandizzi, C; Colucci, R; Fornai, M; Fulceri, F; Natale, G; Tuccori, M; Ugolini, C | 1 |
| Albayrak, Y; Dursun, H; Halici, Z; Odabasoglu, F; Polat, B; Suleyman, B; Suleyman, H; Yigiter, M | 1 |
| Czimmer, J; Mózsik, G; Szabó, IL; Szolcsányi, J | 1 |
| Cadırcı, E; Ozbakış-Dengiz, G; Yurdakan, G | 1 |
| Abourehab, MA; Ahmed, OA; Khaled, KA; Sarhan, HA | 1 |
| Bao, Z; Li, J; Li, S; Pan, W; Wang, H; Xu, L; Yang, B | 1 |
| Albayrak, A; Cadirci, E; Calik, I; Calik, M; Cinar, I; Halici, Z; Sirin, B; Yayla, M | 1 |
| Goto, S; Kasai, T; Komatsu, K; Otsuka, Y; Shimada, Y; Shiono, K; Terada, H | 1 |
| Assali, M; Zohud, N | 1 |
| Abdelfattah, MAO; Abdo, W; Drissi, B; El-Shazly, AM; Mahmoud, MF; Nabil, M; Sobeh, M | 1 |
| Akbaş, EM; Akbaş, N; Gülaboğlu, M; Mammadov, R; Süleyman, B; Süleyman, H | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Avdeef, A; Tam, KY | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Giacomini, KM; Huang, Y; Khuri, N; Kido, Y; Kosaka, A; Morrissey, KM; Sali, A; Wittwer, MB; Zhang, X; Zur, AA | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Bajusz, D; Balogh, GT; Dargó, G; Müller, J; Simon, K | 1 |
2 review(s) available for famotidine and indomethacin
| Article | Year |
|---|---|
Molecular pharmacological approaches to effects of capsaicinoids and of classical antisecretory drugs on gastric basal acid secretion and on indomethacin-induced gastric mucosal damage in human healthy subjects (mini review).
Topics: Adult; Afferent Pathways; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Atropine; Capsaicin; Cimetidine; Dose-Response Relationship, Drug; Famotidine; Female; Gastric Acid; Gastric Mucosa; Humans; Indomethacin; Male; Omeprazole; Peptic Ulcer; Ranitidine | 2013 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
1 trial(s) available for famotidine and indomethacin
| Article | Year |
|---|---|
Molecular pharmacological approaches to effects of capsaicinoids and of classical antisecretory drugs on gastric basal acid secretion and on indomethacin-induced gastric mucosal damage in human healthy subjects (mini review).
Topics: Adult; Afferent Pathways; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Atropine; Capsaicin; Cimetidine; Dose-Response Relationship, Drug; Famotidine; Female; Gastric Acid; Gastric Mucosa; Humans; Indomethacin; Male; Omeprazole; Peptic Ulcer; Ranitidine | 2013 |
52 other study(ies) available for famotidine and indomethacin
| Article | Year |
|---|---|
Possible involvement of hyperinsulinemia and adrenergic activation in the pathogenesis of indomethacin-induced antral ulcers in nonfasted hamsters and refed rats.
Topics: Animals; Atropine; Cricetinae; Famotidine; Fasting; Indomethacin; Insulin; Male; Mesocricetus; Prazosin; Propranolol; Pyloric Antrum; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Stomach Ulcer; Streptozocin; Yohimbine | 1992 |
Antisecretory and antilesional effect of a new histamine H2-receptor antagonist, IT-066, in rats.
Topics: Animals; Cimetidine; Cold Temperature; Cysteamine; Dose-Response Relationship, Drug; Duodenal Neoplasms; Famotidine; Gastric Acid; Gastric Mucosa; Histamine H2 Antagonists; Indomethacin; Male; Perfusion; Piperidines; Pyridines; Rats; Rats, Inbred Strains; Stomach Neoplasms | 1990 |
Sulpiride specifically attenuates psychological stress-induced gastric lesions in rodents.
Topics: Animals; Anti-Ulcer Agents; Famotidine; Gastric Acid; Indomethacin; Male; Mice; Mice, Inbred ICR; Pylorus; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Stress, Mechanical; Stress, Psychological; Sulpiride | 1995 |
YM022 [(R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo-5-phenyl- 1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea], a potent and selective gastrin/cholecystokinin-B receptor antagonist, prevents gastric and duodenal lesions in rats.
Topics: Animals; Anti-Ulcer Agents; Benzodiazepines; Duodenal Ulcer; Epirizole; Ethanol; Famotidine; Gastric Acid; Gastric Mucosa; Hydrogen-Ion Concentration; Indomethacin; Male; Omeprazole; Pyloric Antrum; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Stomach Ulcer; Stress, Physiological | 1994 |
Effects of histamine type-2 receptor antagonists on indomethacin and IL-2 immunotherapy of metastasis.
Topics: Adenocarcinoma; Adjuvants, Immunologic; Animals; Cimetidine; Famotidine; Female; Histamine H2 Antagonists; Immunotherapy, Adoptive; Indomethacin; Interleukin-2; Killer Cells, Natural; Lung Neoplasms; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Neoplasm Metastasis; Neoplasm Transplantation; Ranitidine | 1993 |
[Effects of lansoprazole on indomethacin-induced gastric bleeding and mucosal lesions in rats].
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Dose-Response Relationship, Drug; Famotidine; Gastric Mucosa; Gastrointestinal Hemorrhage; Histamine H2 Antagonists; Indomethacin; Lansoprazole; Male; Omeprazole; Ranitidine; Rats; Rats, Sprague-Dawley | 1996 |
Effect of ebrotidine on ethanol-induced gastric mucosal damage in the rat. Comparative study with other H2-receptor antagonists.
Topics: Animals; Benzenesulfonates; Cimetidine; Dose-Response Relationship, Drug; Ethanol; Famotidine; Female; Gastric Mucosa; Histamine H2 Antagonists; Indomethacin; Peptic Ulcer; Ranitidine; Rats; Rats, Sprague-Dawley; Thiazoles | 1997 |
Antiulcer effect of lafutidine on indomethacin-induced gastric antral ulcers in refed rats.
Topics: 16,16-Dimethylprostaglandin E2; Acetamides; Administration, Oral; Animals; Anti-Ulcer Agents; Capsaicin; Cimetidine; Denervation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Famotidine; Food; Indomethacin; Male; Nitroarginine; Piperidines; Pyloric Antrum; Pyridines; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Wound Healing | 1999 |
Inhibition of gastric acid secretion by nimesulide: a possible factor in its gastric tolerability.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Famotidine; Gastric Acid; Gastric Mucosa; Histamine; Histamine H2 Antagonists; Hydrogen-Ion Concentration; In Vitro Techniques; Indomethacin; Male; Mice; Mice, Inbred C57BL; Muscarine; Perfusion; Sulfonamides | 2001 |
Antiulcerogenic effect of Hippophae rhamnoides L.
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Famotidine; Fruit; Indomethacin; Male; Misoprostol; Omeprazole; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Rosales; Stomach Ulcer; Stress, Physiological | 2001 |
[Effect of exogenous administration of platelet-derived growth factor and epidermal growth factor on duodenal ulcer healing in rats treated with indomethacin].
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Duodenal Ulcer; Epidermal Growth Factor; Famotidine; Indomethacin; Male; Platelet-Derived Growth Factor; Rats; Rats, Wistar; Wound Healing | 2002 |
Effect of nimesulide on gastric acid secretion in the mouse stomach in vitro.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Drug Combinations; Famotidine; Gastric Acid; Gastric Mucosa; Histamine; Histamine H2 Antagonists; Hydrogen-Ion Concentration; In Vitro Techniques; Indomethacin; Male; Mice; Mice, Inbred C57BL; Stomach; Sulfonamides | 2003 |
A23187-activated mast cells affect intestinal function in the pig proximal colon--role for prostaglandins.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcimycin; Colon; Famotidine; Histamine H2 Antagonists; In Vitro Techniques; Indomethacin; Inflammation Mediators; Intestinal Mucosa; Ionophores; Male; Mast Cells; Prostaglandins; Swine | 2003 |
Effect of exogenous administration of transforming growth factor-beta and famotidine on the healing of duodenal ulcer under the impact of indomethacin.
Topics: Animals; Duodenal Ulcer; Famotidine; Gastric Acid; Indomethacin; Male; Rats; Rats, Wistar; Transforming Growth Factor beta | 2003 |
Effects of Momordica charantia L. (Cucurbitaceae) on indomethacin-induced ulcer model in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dietary Fats, Unsaturated; Disease Models, Animal; Drug Therapy, Combination; Famotidine; Fruit; Gastric Mucosa; Histamine H2 Antagonists; Indomethacin; Male; Momordica charantia; Olive Oil; Phytotherapy; Plant Oils; Plant Preparations; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Treatment Outcome | 2005 |
Inhibition of neutrophil activation by lafutidine, an H2-receptor antagonist, through enhancement of sensory neuron activation contributes to the reduction of stress-induced gastric mucosal injury in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Acetamides; Animals; Anti-Ulcer Agents; Arachidonic Acids; Calcitonin Gene-Related Peptide; Capsaicin; Cells, Cultured; Cyclooxygenase Inhibitors; Disease Models, Animal; Endocannabinoids; Famotidine; Ganglia, Spinal; Gastric Acid; Gastric Mucosa; Histamine H2 Antagonists; Indomethacin; Male; Neurons, Afferent; Neutrophil Activation; Peptide Fragments; Piperidines; Polyunsaturated Alkamides; Pyridines; Rats; Rats, Wistar; Restraint, Physical; Stomach Ulcer; Stress, Psychological | 2007 |
Polypropylene imine dendrimer mediated solubility enhancement: effect of pH and functional groups of hydrophobes.
Topics: Amphotericin B; Dendrimers; Drug Stability; Famotidine; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Indomethacin; Polypropylenes; Solubility; Static Electricity; Thermodynamics | 2007 |
Gastroprotective and antioxidant effects of montelukast on indomethacin-induced gastric ulcer in rats.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acetates; Animals; Anti-Ulcer Agents; Antioxidants; Catalase; Cyclopropanes; Dose-Response Relationship, Drug; Famotidine; Gastrointestinal Agents; Glutathione Reductase; Glutathione Transferase; Histamine H2 Antagonists; Indomethacin; Intubation, Gastrointestinal; Lansoprazole; Male; Molecular Structure; Peroxidase; Quinolines; Ranitidine; Rats; Rats, Sprague-Dawley; Stomach; Stomach Ulcer; Sulfides; Superoxide Dismutase | 2007 |
Evaluation of subchronic toxicity of dietary administered Cry1Ab protein from Bacillus thuringiensis var. Kurustaki HD-1 in F344 male rats with chemically induced gastrointestinal impairment.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Bacillus thuringiensis; Bacillus thuringiensis Toxins; Bacterial Proteins; Diet; Eating; Endotoxins; Famotidine; Gastric Acid; Gastrointestinal Diseases; Hemolysin Proteins; Indomethacin; Male; Organ Size; Rats; Rats, Inbred F344; Weight Gain | 2008 |
Protective effect of mirtazapine on indomethacin-induced ulcer in rats and its relationship with oxidant and antioxidant parameters.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antidepressive Agents, Tricyclic; Antioxidants; Famotidine; Glutathione; Indomethacin; Male; Malondialdehyde; Mianserin; Mirtazapine; Oxidative Stress; Oxidoreductases; Rats; Rats, Wistar; Stomach; Stomach Ulcer | 2009 |
Characterization of mechanisms underlying the effects of esomeprazole on the impairment of gastric ulcer healing with addition of NSAID treatment.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Caspase 3; Dinoprostone; Disease Models, Animal; Esomeprazole; Famotidine; Indomethacin; Male; Malondialdehyde; Melatonin; NF-kappa B; Proliferating Cell Nuclear Antigen; Rats; Rats, Wistar; Stomach Ulcer; Treatment Outcome; Wound Healing | 2009 |
Comparative study on the gastroprotective potential of some antidepressants in indomethacin-induced ulcer in rats.
Topics: Animals; Anti-Ulcer Agents; Antidepressive Agents; Cyclohexanols; Famotidine; Indomethacin; Male; Rats; Rats, Inbred WF; Stomach Ulcer; Thiazepines; Trazodone; Venlafaxine Hydrochloride | 2009 |
Mitigation of indomethacin-induced gastric mucosal lesions by a potent specific type V phosphodiesterase inhibitor.
Topics: Animals; Antineoplastic Agents; Cyclooxygenase Inhibitors; Famotidine; Female; Gastric Mucosa; Humans; Imidazoles; Indomethacin; Malondialdehyde; Nitric Oxide; Oxidative Stress; Phosphodiesterase Inhibitors; Piperazines; Rats; Rats, Wistar; Sulfones; Triazines; Vardenafil Dihydrochloride | 2009 |
Protective effect of roxatidine against indomethacin-induced small intestinal mucosal injury in rats.
Topics: Animals; Anti-Ulcer Agents; Cimetidine; Disease Models, Animal; Famotidine; Histamine H2 Antagonists; Indomethacin; Intestinal Mucosa; Intestine, Small; Male; Mucus; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peptic Ulcer; Piperidines; Prostaglandins; Rats; Rats, Sprague-Dawley | 2010 |
The role of erythropoietin in the protection of gastric mucosa from indometacin-induced gastric injury and its relationship with oxidant and antioxidant parameters in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Dose-Response Relationship, Drug; Erythropoietin; Famotidine; Gastric Mucosa; Glutathione; Indomethacin; Male; Oxidants; Peroxidase; Rats; Rats, Wistar; Stomach Ulcer; Superoxide Dismutase | 2010 |
Effects of esomeprazole on healing of nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcers in the presence of a continued NSAID treatment: Characterization of molecular mechanisms.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Apoptosis; Blotting, Western; Caspase 3; Cell Proliferation; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Esomeprazole; Famotidine; Gastric Acid; Gastric Mucosa; Histamine H2 Antagonists; Immunohistochemistry; Indomethacin; Ki-67 Antigen; Lansoprazole; Male; Malondialdehyde; Proliferating Cell Nuclear Antigen; Proton Pump Inhibitors; Rats; Rats, Wistar; Stomach Ulcer; Time Factors; Vascular Endothelial Growth Factor A; Wound Healing | 2011 |
Antiulcerative effect of dexmedetomidine on indomethacin-induced gastric ulcer in rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Dexmedetomidine; Disease Models, Animal; Dose-Response Relationship, Drug; Famotidine; Indomethacin; Male; Oxidants; Rats; Rats, Wistar; Stomach Ulcer | 2011 |
Histopathologic evaluation of anti-ulcerogenic effect of montelukast in indomethacin-induced experimental ulcer model.
Topics: Acetates; Animals; Anti-Ulcer Agents; Cyclopropanes; Disease Models, Animal; Famotidine; Gastric Mucosa; Indomethacin; Leukocyte Count; Leukotriene Antagonists; Male; Neutrophils; Quinolines; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Sulfides | 2013 |
Evaluation of combined famotidine with quercetin for the treatment of peptic ulcer: in vivo animal study.
Topics: Alginates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Drug Carriers; Drug Combinations; Famotidine; Indomethacin; Male; Particle Size; Peptic Ulcer; Polymethacrylic Acids; Quercetin; Rats | 2015 |
Facile synthesis of functionalized ionic surfactant templated mesoporous silica for incorporation of poorly water-soluble drug.
Topics: Drug Carriers; Drug Liberation; Famotidine; Indomethacin; Porosity; Propylamines; Silanes; Silicon Dioxide; Solubility; Surface-Active Agents; Water | 2015 |
LP44 (4-[2-(methylthio)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazinehexanamide) exerts anti-ulcer effects via 5-hydroxytryptamine receptor 7 activation on indomethacin-induced gastric ulcers in rats.
Topics: Amides; Animals; Famotidine; Gene Expression; Indomethacin; Male; Nitric Oxide Synthase Type III; Phenols; Piperazines; Rats; Rats, Wistar; Receptors, Serotonin; RNA, Messenger; Serotonin Antagonists; Serotonin Receptor Agonists; Stomach Ulcer; Sulfonamides | 2020 |
Molecular recognizable ion-paired complex formation between diclofenac/indomethacin and famotidine/cimetidine regulates their aqueous solubility.
Topics: Cimetidine; Diclofenac; Famotidine; Indomethacin; Solubility; Water | 2020 |
Design of multicomponent indomethacin-paracetamol and famotidine loaded nanoparticles for sustained and effective anti-inflammatory therapy.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Drug Compounding; Emulsions; Famotidine; Fibroblasts; HeLa Cells; Histamine H2 Antagonists; Humans; Indomethacin; Molecular Structure; Nanoparticles | 2021 |
Apple (Malus domestica Borkh) leaves attenuate indomethacin-induced gastric ulcer in rats.
Topics: Animals; Cyclooxygenase 2; Cytokines; Famotidine; Gastric Mucosa; Gastritis; HSP70 Heat-Shock Proteins; Indomethacin; Malus; Rats; Stomach Ulcer | 2023 |
Effect of felodipine on indomethacin-induced gastric ulcers in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Famotidine; Felodipine; Indomethacin; Rats; Rats, Wistar; Stomach Ulcer | 2023 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Prediction of drug intestinal absorption by new linear and non-linear QSPR.
Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling.
Topics: Computer Simulation; Fluorescent Dyes; Organic Cation Transport Proteins; Prescription Drugs | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Human Serum Albumin Binding in a Vial: A Novel UV-pH Titration Method To Assist Drug Design.
Topics: Binding Sites; Chemistry, Pharmaceutical; Drug Design; Humans; Hydrogen-Ion Concentration; Molecular Docking Simulation; Pharmaceutical Preparations; Protein Binding; Serum Albumin, Human; Spectrophotometry, Ultraviolet; Titrimetry | 2020 |