famotidine has been researched along with aspirin in 44 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (4.55) | 18.7374 |
| 1990's | 1 (2.27) | 18.2507 |
| 2000's | 12 (27.27) | 29.6817 |
| 2010's | 27 (61.36) | 24.3611 |
| 2020's | 2 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Bhaskar, NK; Daneshmend, TK; Hawkey, CJ; Millns, PJ; Prichard, PJ | 1 |
| Maeno, H; Takagi, T; Takeda, M; Yashima, Y | 1 |
| Ayukawa, O; Kariyazono, H; Moriyama, Y; Nakamura, K; Shinkawa, T; Taira, A; Toyohira, H; Yamada, K; Yamaguchi, T; Yamashita, T; Yotsumoto, G | 1 |
| Arbak, S; Ayanoğlu-Dülger, G; Hürdağ, C; Paskaloğlu, K; Sener-Muratoğlu, G | 1 |
| Denton, MB; Liang, Y; Simon, RE; Walton, LK | 1 |
| Akay, C; Degim, T; Degim, Z; Zaimoglu, V | 1 |
| Bezlyak, V; McCloskey, C; Prasad, R; Taha, AS | 1 |
| Hawkey, CJ | 1 |
| Chan, P; Chu, WM; Kng, C; Kwan, A; Lam, KF; Lau, YK; Ling, YH; Ng, FH; Wong, BC; Wong, SY; Yuen, WC | 1 |
| Furuta, T; Hishida, A; Ikuma, M; Kodaira, C; Nishino, M; Shirai, N; Sugimoto, M; Sugimura, H; Tanaka, T; Uotani, T; Yamade, M | 1 |
| Sugiyama, T; Yamawaki, H | 1 |
| Kato, M; Nema, H | 1 |
| Hiraishi, H; Kanke, K; Maeda, M; Sasai, T; Shimada, T | 1 |
| Chan, K; Chu, WM; Keung, KK; Kng, C; Kwan, A; Lam, KF; Lau, YK; Li, A; Ng, FH; Tunggal, P; Wong, BC | 1 |
| Furuta, T; Ikuma, M; Kodaira, C; Nishino, M; Sugimoto, M; Uotani, T; Yamade, M | 1 |
| Hashimoto, E; Izuhara, C; Kaneko, S; Takayama, S; Takeuchi, K; Yamada, N; Yamanaka, S | 1 |
| Ong, CT; Sung, SF; Tong, SH; Wu, CS | 1 |
| Endo, T; Fukui, K; Hibi, K; Himeno, H; Kimura, K; Morita, S; Sugano, T; Tsukahara, K; Umemura, S; Yano, H | 1 |
| Aburadani, I; Inomata, J; Kinoshita, M; Kurokawa, K; Maruyama, M; Nagata, Y; Usuda, K | 1 |
| Horiuchi, H | 1 |
| Kadota, J; Murakami, K; Tamura, A | 1 |
| Abramowitz, Y; Arbel, Y; Banai, S; Berliner, S; Birati, EY; Deutsch, V; Finkelstein, A; Halkin, A; Herz, I; Keren, G; Kletzel, H | 1 |
| Furuta, T; Ichikawa, H; Iwaizumi, M; Miyajima, H; Nishino, M; Osawa, S; Sahara, S; Sugimoto, K; Sugimoto, M; Umemura, K; Uotani, T; Watanabe, H; Yamada, T; Yamade, M | 1 |
| Chan, HH; Chen, WC; Cheng, JS; Chiang, PH; Lai, KH; Li, YD; Tsai, TJ; Tsai, WL; Tsay, FW; Wang, EM | 1 |
| Azuma, T; Fujimoto, K; Fujita, T; Harada, S; Higuchi, K; Inoue, T; Iwakiri, R; Kojima, Y; Ota, K; Sakata, Y; Takeuchi, T | 1 |
| Abe, T; Arakawa, T; Chan, FK; Chan, H; Cheong, PK; Ching, JY; Fujimoto, K; Handa, O; Higuchi, K; Kinoshita, Y; Kyaw, M; Lam, K; Lee, V; Lo, A; Lui, R; Mishiro, T; Naito, Y; Nebiki, H; Ng, SC; Sakata, Y; Takeuchi, T; Tang, RS; Tanigawa, T; Tse, YK; Watanabe, T; Wu, JC | 1 |
| Chen, C; Huang, S; Lin, D; Luo, Y; Wu, Y; Yu, W | 1 |
| Chen, WC; Cheng, JS; Chuah, SK; Hsu, PI; Kao, SS; Peng, NJ; Shie, CB; Tang, SY; Tsai, KF; Tsay, FW; Tseng, ZF | 1 |
| Akbas, N; Altuner, D; Bulut, S; Cerrah, S; Mammadov, R; Ozcicek, F; Suleyman, H | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
3 review(s) available for famotidine and aspirin
| Article | Year |
|---|---|
[Mucoprotective drugs and aspirin-induced gastric injury].
Topics: Aged; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Famotidine; Humans; Stomach Ulcer | 2010 |
[Strategy to manage low dose aspirin-induced gastrointestinal injury].
Topics: Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Cerebrovascular Disorders; Clopidogrel; Famotidine; Gastric Mucosa; Humans; Omeprazole; Peptic Ulcer; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Proton Pump Inhibitors; Ticlopidine | 2011 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
13 trial(s) available for famotidine and aspirin
| Article | Year |
|---|---|
Use of microbleeding and an ultrathin endoscope to assess gastric mucosal protection by famotidine.
Topics: Adolescent; Adult; Aspirin; Double-Blind Method; Famotidine; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; Gastroscopes; Gastroscopy; Histamine H2 Antagonists; Humans; Male; Thiazoles | 1989 |
Famotidine for the prevention of peptic ulcers and oesophagitis in patients taking low-dose aspirin (FAMOUS): a phase III, randomised, double-blind, placebo-controlled trial.
Topics: Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Double-Blind Method; Esophagitis; Famotidine; Female; Fibrinolytic Agents; Helicobacter Infections; Helicobacter pylori; Histamine H2 Antagonists; Humans; Logistic Models; Male; Middle Aged; Peptic Ulcer; Risk Factors; Scotland; Statistics, Nonparametric | 2009 |
Famotidine is inferior to pantoprazole in preventing recurrence of aspirin-related peptic ulcers or erosions.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Famotidine; Female; Follow-Up Studies; Gastrointestinal Hemorrhage; Helicobacter Infections; Histamine H2 Antagonists; Humans; Male; Middle Aged; Pantoprazole; Peptic Ulcer; Risk Factors; Secondary Prevention; Treatment Outcome | 2010 |
Preventive effects of lansoprazole and famotidine on gastric mucosal injury induced by low-dose aspirin in Helicobacter pylori-negative healthy volunteers.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aryl Hydrocarbon Hydroxylases; Aspirin; Cross-Over Studies; Cytochrome P-450 CYP2C19; Famotidine; Female; Gastric Acidity Determination; Gastric Mucosa; Genotype; Histamine H2 Antagonists; Humans; Japan; Lansoprazole; Male; Proton Pump Inhibitors; Severity of Illness Index; Stomach Ulcer; Young Adult | 2011 |
Comparative study of therapeutic effects of PPI and H2RA on ulcers during continuous aspirin therapy.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Drug Therapy, Combination; Endoscopy; Famotidine; Histamine H2 Antagonists; Humans; Lansoprazole; Male; Middle Aged; Peptic Ulcer; Prospective Studies; Proton Pump Inhibitors; Ranitidine; Treatment Outcome; Wound Healing | 2010 |
Esomeprazole compared with famotidine in the prevention of upper gastrointestinal bleeding in patients with acute coronary syndrome or myocardial infarction.
Topics: Acute Coronary Syndrome; Aged; Anti-Ulcer Agents; Aspirin; Chi-Square Distribution; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Enoxaparin; Esomeprazole; Famotidine; Female; Fibrinolytic Agents; Follow-Up Studies; Gastrointestinal Hemorrhage; Humans; Intestinal Perforation; Male; Middle Aged; Platelet Aggregation Inhibitors; Proportional Hazards Models; Ticlopidine; Treatment Outcome | 2012 |
Impact of acid inhibition on esophageal mucosal injury induced by low-dose aspirin.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aspirin; Cross-Over Studies; Esophagus; Famotidine; Female; Gastric Acid; Gastric Acidity Determination; Gastroesophageal Reflux; Gastroscopy; Humans; Lansoprazole; Male; Mucous Membrane; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Rabeprazole; Treatment Outcome; Young Adult | 2012 |
Influence of omeprazole and famotidine on the antiplatelet effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes: a prospective, randomized, multicenter study.
Topics: Acute Coronary Syndrome; Aged; Anti-Ulcer Agents; Aspirin; Blood Platelets; Clopidogrel; Drug Antagonism; Famotidine; Female; Humans; Male; Middle Aged; Myocardial Infarction; Omeprazole; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2012 |
Platelet inhibitory effect of clopidogrel in patients treated with omeprazole, pantoprazole, and famotidine: a prospective, randomized, crossover study.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Aged, 80 and over; Aspirin; Chi-Square Distribution; Clopidogrel; Cross-Over Studies; Drug Interactions; Drug Resistance; Drug Therapy, Combination; Famotidine; Female; Histamine H2 Antagonists; Humans; Israel; Linear Models; Male; Middle Aged; Omeprazole; Pantoprazole; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Proton Pump Inhibitors; Single-Blind Method; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
Prevention of gastric mucosal injury induced by anti-platelet drugs by famotidine.
Topics: Adult; Anti-Ulcer Agents; Asian People; Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Therapy, Combination; Famotidine; Female; Gastric Acidity Determination; Gastric Mucosa; Genotype; Helicobacter Infections; Helicobacter pylori; Histamine H2 Antagonists; Humans; Hydrogen-Ion Concentration; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Young Adult | 2014 |
Comparison of teprenone and famotidine against gastroduodenal mucosal damage in patients taking low-dose aspirin.
Topics: Aged; Anti-Ulcer Agents; Aspirin; Diterpenes; Famotidine; Female; Histamine H2 Antagonists; Humans; Male; Middle Aged; Peptic Ulcer; Prospective Studies; Treatment Outcome | 2014 |
Similar Efficacy of Proton-Pump Inhibitors vs H2-Receptor Antagonists in Reducing Risk of Upper Gastrointestinal Bleeding or Ulcers in High-Risk Users of Low-Dose Aspirin.
Topics: Aged; Aged, 80 and over; Aspirin; Double-Blind Method; Famotidine; Female; Hemoglobins; Histamine H2 Antagonists; Humans; Male; Middle Aged; Peptic Ulcer; Peptic Ulcer Hemorrhage; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Rabeprazole; Recurrence; Risk Factors; Secondary Prevention | 2017 |
Omeprazole vs famotidine for the prevention of gastroduodenal injury in high-risk users of low-dose aspirin: A randomized controlled trial.
Topics: Aged; Aged, 80 and over; Aspirin; Famotidine; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; Humans; Intestinal Mucosa; Male; Middle Aged; Omeprazole; Risk Factors | 2021 |
28 other study(ies) available for famotidine and aspirin
| Article | Year |
|---|---|
Effect of a new potent H2-blocker, 3-[[[2-(diaminomethylene)amino]-4-thiazolyl]methyl]thio]-N2-sulfamoyl propionamidine (YM-11170), on gastric secretion, ulcer formation and weight of male accessory sex organs in rats.
Topics: Androgen Antagonists; Animals; Aspirin; Castration; Cimetidine; Famotidine; Gastric Juice; Gastric Mucosa; Genitalia, Male; Histamine H2 Antagonists; Male; Organ Size; Rats; Rats, Inbred Strains; Stomach Ulcer; Testosterone; Thiazoles | 1982 |
Inhibitory effects of H2-receptor antagonists on platelet function in vitro.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Blood Platelets; Cimetidine; Collagen; Famotidine; Female; Heterocyclic Compounds, 1-Ring; Histamine H2 Antagonists; Humans; In Vitro Techniques; Male; Middle Aged; P-Selectin; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Ranitidine; Structure-Activity Relationship | 1999 |
Protective effect of famotidine, omeprazole, and melatonin against acetylsalicylic acid-induced gastric damage in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Aspirin; Disease Models, Animal; Drug Evaluation, Preclinical; Famotidine; Female; Free Radical Scavengers; Gastric Acidity Determination; Lipid Peroxidation; Male; Melatonin; Omeprazole; Rats; Stomach Ulcer | 2001 |
Fluorescence quenching high-performance thin-layer chromatographic analysis utilizing a scientifically operated charge-coupled device detector.
Topics: Acetaminophen; Aspirin; Autoanalysis; Caffeine; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Famotidine; Sensitivity and Specificity; Signal Processing, Computer-Assisted | 2001 |
pH-Metric log K calculations of famotidine, naproxen, nizatidine, ranitidine and salicylic acid.
Topics: Anti-Inflammatory Agents; Anti-Ulcer Agents; Aspirin; Chromatography, High Pressure Liquid; Computers; Famotidine; Hydrogen-Ion Concentration; Naproxen; Nizatidine; Ranitidine; Structure-Activity Relationship | 2001 |
NSAIDs and aspirin: notorious or FAMOUS?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Cyclooxygenase Inhibitors; Esophagitis; Famotidine; Helicobacter Infections; Helicobacter pylori; Humans; Patient Selection; Peptic Ulcer; Risk Factors; Safety | 2009 |
A new model of gastric bleeding induced in rats by aspirin plus clopidogrel under stimulation of acid secretion. Prophylactic effects of antiulcer drugs.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Clopidogrel; Drug Interactions; Famotidine; Gastric Acid; Gastric Mucosa; Gastrointestinal Hemorrhage; Male; Omeprazole; Peroxidase; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Ticlopidine | 2012 |
Multiple cerebral infarctions related to famotidine-induced eosinophilia.
Topics: Acarbose; Adrenergic alpha-1 Receptor Antagonists; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antihypertensive Agents; Aspirin; Calcium Channel Blockers; Cerebral Infarction; Diabetes Mellitus, Type 2; Diffusion Magnetic Resonance Imaging; Drug-Related Side Effects and Adverse Reactions; Eosinophilia; Famotidine; Humans; Hypertension; Hypoglycemic Agents; Labetalol; Male; Metformin; Middle Aged; Nifedipine; Peptic Ulcer; Prazosin; Sulfonylurea Compounds | 2012 |
Impact of proton pump inhibitors or famotidine on the antiplatelet actions during dual-antiplatelet therapy in Japanese patients.
Topics: Aged; Asian People; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Drug Interactions; Famotidine; Female; Histamine H2 Antagonists; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Proton Pump Inhibitors; Ticlopidine | 2013 |
Proton-pump inhibitors could be innocent when used concomitantly with clopidogrel.
Topics: Acute Coronary Syndrome; Anti-Ulcer Agents; Aspirin; Blood Platelets; Clopidogrel; Famotidine; Female; Humans; Male; Omeprazole; Platelet Aggregation Inhibitors; Ticlopidine | 2012 |
Prevalence of gastroduodenal ulcers/erosions in patients taking low-dose aspirin with either 15 mg/day of lansoprazole or 40 mg/day of famotidine: the OITA-GF study 2.
Topics: Aged; Anti-Ulcer Agents; Aspirin; Cohort Studies; Cross-Sectional Studies; Drug Administration Schedule; Endoscopy; Famotidine; Female; Gastric Mucosa; Humans; Lansoprazole; Male; Middle Aged; Peptic Ulcer; Prevalence; Steroids | 2013 |
Comparison of proton pump inhibitor and histamine-2 receptor antagonist in the prevention of recurrent peptic ulcers/erosions in long-term low-dose aspirin users: a retrospective cohort study.
Topics: Aged; Aged, 80 and over; Aspirin; Cohort Studies; Drug-Related Side Effects and Adverse Reactions; Famotidine; Female; Histamine H2 Antagonists; Humans; Male; Middle Aged; Omeprazole; Peptic Ulcer; Proton Pump Inhibitors; Retrospective Studies; Thromboembolism | 2014 |
The effect of esomeprazole vs famotidine on aspirin/clopidogrel dual therapy after percutaneous coronary intervention.
Topics: Aspirin; Blood Platelets; Clopidogrel; Drug Therapy, Combination; Esomeprazole; Famotidine; Humans; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine; Treatment Outcome | 2019 |
Effects of taxifolin on aspirin-induced gastric damage in rats: macroscopic and biochemical evaluation.
Topics: Animals; Antioxidants; Aspirin; Famotidine; Quercetin; Rats | 2023 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Prediction of drug intestinal absorption by new linear and non-linear QSPR.
Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |