Page last updated: 2024-08-24

fadrozole and letrozole

fadrozole has been researched along with letrozole in 28 studies

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's14 (50.00)18.2507
2000's10 (35.71)29.6817
2010's3 (10.71)24.3611
2020's1 (3.57)2.80

Authors

AuthorsStudies
Muftuoglu, Y; Mustata, G1
Cushman, M; Kondratyuk, TP; Marler, L; Mayhoub, AS; Park, EJ; Pezzuto, JM1
Hartmann, RW; Hu, Q; Yin, L1
Chen, JZ; Khan, MZI; Nazli, A; Uzair, M1
Borja, J; Pérez, N1
Beh, I; Bhatnagar, AS; Müller, P; Schenkel, L; Schieweck, K; Trunet, PF1
Bhatnagar, AS; Bowman, R; Häusler, A; Lang, M; Schieweck, K1
Brodie, A; Savinov, A; Wang, J; Yue, W1
Bergeron, JM; Crews, D1
Demers, LM1
Manni, A1
Batzl, C; Bhatnagar, AS; Bowman, R; Furet, P; Häusler, A; Lang, M1
Crews, D; Wennstrom, KL1
Bhatnagar, S; Krishnamurthy, H; Krishnamurthy, HN; Moudgal, RN; Shetty, G1
Norton, A; Smith, IE1
Bershteĭn, LM; Larionov, AA; Poroshina, TE; Zimarina, TS1
Dowsett, M1
Smith, IE1
Sonoo, H1
Auvray, P; Bichat, F; Genne, P1
de Crémoux, P1
Buzdar, A; Howell, A1
Buzdar, AU1
Adachi, I; Ikeda, T; Ohashi, Y; Sasaki, Y; Suwa, T; Tabei, T; Takatsuka, Y; Toi, M; Tominaga, T1
Hori, H; Kagawa, N; Waterman, MR; Yoshioka, S1
Bria, E; Carlini, P; Cognetti, F; Di Cosimo, S; Fabi, A; Felici, A; Ferretti, G; Giannarelli, D; Milella, M; Mottolese, M; Nisticò, C; Papaldo, P; Ruggeri, EM; Terzoli, E1
Ioannidis, JP; Mauri, D; Pavlidis, N; Polyzos, NP1
Dutta, U; Pant, K1

Reviews

15 review(s) available for fadrozole and letrozole

ArticleYear
An overview on Estrogen receptors signaling and its ligands in breast cancer.
    European journal of medicinal chemistry, 2022, Nov-05, Volume: 241

    Topics: Breast Neoplasms; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens; Female; Humans; Ligands; Male; Receptors, Estrogen

2022
Aromatase inhibitors: clinical pharmacology and therapeutic implications in breast cancer.
    The Journal of international medical research, 1992, Volume: 20, Issue:4

    Topics: Aminoglutethimide; Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Fadrozole; Female; Humans; Imidazoles; Letrozole; Nitriles; Triazoles

1992
Highly selective inhibition of estrogen biosynthesis by CGS 20267, a new non-steroidal aromatase inhibitor.
    The Journal of steroid biochemistry and molecular biology, 1990, Dec-20, Volume: 37, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Aromatase Inhibitors; Estrogen Antagonists; Estrogens; Fadrozole; Imidazoles; Letrozole; Mammary Neoplasms, Experimental; Nitriles; Steroids; Triazoles

1990
Clinical use of aromatase inhibitors in the treatment of breast cancers.
    Journal of cellular biochemistry. Supplement, 1993, Volume: 17G

    Topics: Aminoglutethimide; Animals; Aromatase Inhibitors; Breast Neoplasms; Fadrozole; Female; Humans; Letrozole; Nitriles; Rats; Triazoles

1993
Fadrozole and letrozole in advanced breast cancer: clinical and biochemical effects.
    Breast cancer research and treatment, 1998, Volume: 49 Suppl 1

    Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Enzyme Inhibitors; Fadrozole; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Randomized Controlled Trials as Topic; Triazoles

1998
Drug and hormone interactions of aromatase inhibitors.
    Endocrine-related cancer, 1999, Volume: 6, Issue:2

    Topics: Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Drug Interactions; Enzyme Inhibitors; Estrogens; Fadrozole; Female; Humans; Letrozole; Male; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Premenopause; Sensitivity and Specificity; Tamoxifen; Triazoles

1999
Aromatase inhibitors: a dose-response effect?
    Endocrine-related cancer, 1999, Volume: 6, Issue:2

    Topics: Aminoglutethimide; Anastrozole; Animals; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estrogens; Fadrozole; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Triazoles

1999
[Aromatase inhibitors for treatment of advanced breast cancers].
    Nihon rinsho. Japanese journal of clinical medicine, 2000, Volume: 58 Suppl

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Estrogen Antagonists; Fadrozole; Female; Humans; Letrozole; Nitriles; Treatment Outcome; Triazoles

2000
[Preclinical evaluation of aromatase inhibitors antitumor activity].
    Bulletin du cancer, 2000, Volume: 87 Spec No

    Topics: Aminoglutethimide; Anastrozole; Androstadienes; Androstenedione; Animals; Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Drug Evaluation, Preclinical; Enzyme Inhibitors; Fadrozole; Female; Humans; Letrozole; Models, Animal; Nitriles; Rats; Structure-Activity Relationship; Triazoles

2000
[Aromatase inhibitors: pharmacological aspects].
    Bulletin du cancer, 2000, Volume: 87 Spec No

    Topics: Aminoglutethimide; Anastrozole; Androstadienes; Androstenedione; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Enzyme Inhibitors; Fadrozole; Female; Humans; Letrozole; Nitriles; Triazoles

2000
Advances in aromatase inhibition: clinical efficacy and tolerability in the treatment of breast cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:9

    Topics: Anastrozole; Androstadienes; Androstenedione; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Fadrozole; Female; Headache; Humans; Letrozole; Nausea; Nitriles; Treatment Outcome; Triazoles; Vomiting

2001
A summary of second-line randomized studies of aromatase inhibitors.
    The Journal of steroid biochemistry and molecular biology, 2001, Volume: 79, Issue:1-5

    Topics: Aminoglutethimide; Anastrozole; Androstadienes; Aromatase Inhibitors; Breast Neoplasms; Drug Tolerance; Enzyme Inhibitors; Estrogen Receptor Modulators; Fadrozole; Female; Humans; Letrozole; Megestrol Acetate; Neoplasms, Hormone-Dependent; Nitriles; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles

2001
New aromatase inhibitors as second-line endocrine therapy in postmenopausal patients with metastatic breast carcinoma: a pooled analysis of the randomized trials.
    Cancer, 2005, Oct-01, Volume: 104, Issue:7

    Topics: Aged; Anastrozole; Androstenedione; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Carcinoma; Clinical Trials, Phase III as Topic; Confidence Intervals; Dose-Response Relationship, Drug; Drug Administration Schedule; Fadrozole; Female; Humans; Letrozole; Middle Aged; Neoplasm Staging; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Probability; Prognosis; Remission Induction; Risk Assessment; Survival Analysis; Triazoles

2005
Survival with aromatase inhibitors and inactivators versus standard hormonal therapy in advanced breast cancer: meta-analysis.
    Journal of the National Cancer Institute, 2006, Sep-20, Volume: 98, Issue:18

    Topics: Adult; Aged; Aminoglutethimide; Anastrozole; Androstenedione; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Fadrozole; Female; Humans; Letrozole; Middle Aged; Neoplasm Staging; Neoplasms, Hormone-Dependent; Nitriles; Odds Ratio; Randomized Controlled Trials as Topic; Survival Analysis; Triazoles

2006
Aromatase inhibitors: past, present and future in breast cancer therapy.
    Medical oncology (Northwood, London, England), 2008, Volume: 25, Issue:2

    Topics: Aminoglutethimide; Androstadienes; Androstenedione; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Fadrozole; Female; Humans; Letrozole; Nitriles; Triazoles

2008

Trials

2 trial(s) available for fadrozole and letrozole

ArticleYear
Effects of Fadrozole (CGS 16949A) and Letrozole (CGS 20267) on the inhibition of aromatase activity in breast cancer patients.
    Breast cancer research and treatment, 1994, Volume: 30, Issue:1

    Topics: Aromatase Inhibitors; Breast Neoplasms; Estradiol; Estrogens; Estrone; Fadrozole; Female; Humans; Letrozole; Middle Aged; Nitriles; Radioimmunoassay; Triazoles

1994
Double-blind randomised trial comparing the non-steroidal aromatase inhibitors letrozole and fadrozole in postmenopausal women with advanced breast cancer.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2003, Volume: 14, Issue:1

    Topics: Administration, Oral; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Disease Progression; Double-Blind Method; Enzyme Inhibitors; Estradiol; Estrone; Fadrozole; Female; Humans; Letrozole; Middle Aged; Neoplasm Recurrence, Local; Nitriles; Postmenopause; Receptors, Estrogen; Receptors, Progesterone; Safety; Survival Rate; Triazoles

2003

Other Studies

11 other study(ies) available for fadrozole and letrozole

ArticleYear
Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19).
    Bioorganic & medicinal chemistry letters, 2010, May-15, Volume: 20, Issue:10

    Topics: Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Binding Sites; Breast Neoplasms; Computer Simulation; Drug Design; Female; Humans; Models, Chemical; Models, Molecular; Structure-Activity Relationship

2010
Optimization of the aromatase inhibitory activities of pyridylthiazole analogues of resveratrol.
    Bioorganic & medicinal chemistry, 2012, Apr-01, Volume: 20, Issue:7

    Topics: Aromatase; Aromatase Inhibitors; Binding Sites; Catalytic Domain; Computer Simulation; Enzyme Assays; Humans; Resveratrol; Stilbenes; Structure-Activity Relationship; Thiazoles

2012
Tetrahydropyrroloquinolinone type dual inhibitors of aromatase/aldosterone synthase as a novel strategy for breast cancer patients with elevated cardiovascular risks.
    Journal of medicinal chemistry, 2013, Jan-24, Volume: 56, Issue:2

    Topics: Aromatase Inhibitors; Breast Neoplasms; Cardiovascular Diseases; Cytochrome P-450 CYP11B2; Female; Humans; Magnetic Resonance Spectroscopy; Models, Molecular; Quinolones; Risk Factors; Spectrometry, Mass, Electrospray Ionization

2013
Inhibition of estrogen biosynthesis and its consequences on gonadotrophin secretion in the male.
    The Journal of steroid biochemistry and molecular biology, 1992, Volume: 41, Issue:3-8

    Topics: Animals; Aromatase Inhibitors; Estradiol; Estrogen Antagonists; Fadrozole; Follicle Stimulating Hormone; Humans; Imidazoles; Letrozole; Luteinizing Hormone; Male; Nitriles; Organ Size; Rats; Reference Values; Testosterone; Triazoles

1992
Effect of aromatase inhibitors on growth of mammary tumors in a nude mouse model.
    Cancer research, 1995, Jul-15, Volume: 55, Issue:14

    Topics: Androstenedione; Animals; Antineoplastic Agents; Aromatase Inhibitors; Cell Division; Fadrozole; Female; Letrozole; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Nitriles; Organ Size; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Triazoles; Uterus

1995
Role of reductase and aromatase in sex determination in the red-eared slider (Trachemys scripta), a turtle with temperature-dependent sex determination.
    The Journal of endocrinology, 1994, Volume: 143, Issue:2

    Topics: Animals; Aromatase; Aromatase Inhibitors; Azasteroids; Dihydrotestosterone; Dose-Response Relationship, Drug; Fadrozole; Female; Finasteride; Letrozole; Male; Nitriles; Oxidoreductases; Sex Determination Analysis; Sex Ratio; Temperature; Testosterone; Triazoles; Turtles

1994
Structure-activity relationships and binding model of novel aromatase inhibitors.
    The Journal of steroid biochemistry and molecular biology, 1993, Volume: 44, Issue:4-6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aromatase Inhibitors; Fadrozole; Female; Humans; Letrozole; Microsomes; Models, Molecular; Molecular Structure; Nitriles; Placenta; Pregnancy; Structure-Activity Relationship; Tetrazoles; Triazoles

1993
Making males from females: the effects of aromatase inhibitors on a parthenogenetic species of whiptail lizard.
    General and comparative endocrinology, 1995, Volume: 99, Issue:3

    Topics: Animals; Aromatase Inhibitors; Enzyme Inhibitors; Fadrozole; Female; Letrozole; Lizards; Male; Nitriles; Parthenogenesis; Sex Determination Analysis; Sex Differentiation; Triazoles

1995
Effect of estrogen deprivation on the reproductive physiology of male and female primates.
    The Journal of steroid biochemistry and molecular biology, 1997, Volume: 61, Issue:3-6

    Topics: Animals; Aromatase; Aromatase Inhibitors; Enzyme Inhibitors; Estrogen Antagonists; Estrogens; Fadrozole; Female; Letrozole; Macaca radiata; Male; Nitriles; Pregnancy; Reproduction; Triazoles

1997
[Metabolism of the androgenic precursor androstenedione and effects of aromatase inhibitors in cultured blood lymphocytes].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 1998, Volume: 84, Issue:11

    Topics: Adolescent; Adult; Age Factors; Aged; Androstenedione; Aromatase Inhibitors; Bucladesine; Cells, Cultured; Dexamethasone; Enzyme Inhibitors; Fadrozole; Female; Humans; Letrozole; Lymphocytes; Middle Aged; Nitriles; Triazoles

1998
Characterization of stable human aromatase expressed in E. coli.
    Steroids, 2004, Volume: 69, Issue:4

    Topics: Amino Acid Sequence; Androstenedione; Arginine; Aromatase; Aromatase Inhibitors; Cell Membrane; Chaperonin 10; Chaperonin 60; Chloramphenicol; Cysteine; Electron Spin Resonance Spectroscopy; Enzyme Stability; Escherichia coli; Estradiol; Estrone; Fadrozole; Gene Expression; Humans; Letrozole; Molecular Sequence Data; Nitriles; Polymorphism, Genetic; Protein Structure, Secondary; Protein Synthesis Inhibitors; Recombinant Proteins; Solubility; Testosterone; Triazoles

2004