Page last updated: 2024-08-24

fadrozole and aldosterone

fadrozole has been researched along with aldosterone in 26 studies

Research

Studies (26)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (7.69)	18.7374
1990's	5 (19.23)	18.2507
2000's	4 (15.38)	29.6817
2010's	13 (50.00)	24.3611
2020's	2 (7.69)	2.80

Authors

Authors	Studies
Aupetit, B; Bhatnagar, AS; Ezzet, F; Girard, F; Menard, J; Mueller, P; Trunet, PF; Zognbi, F	1
Demers, LM; Garber, JE; Hanagan, J; Harvey, H; Henderson, IC; Lipton, A; Lynch, J; Mulagha, M; Navari, RM; Santen, RJ	1
Coombes, RC; Davenport, J; Dowsett, M; Ford, HT; Gazet, JC; Hedley, A; Stein, RC	1
Demers, LM; Harvey, HA; Lipton, A; Melby, JC; Santen, RJ; Wilson, TE	1
Bhatnagar, AS; Borer, C; Häusler, A; Monnet, G	1
Blijd, JJ; Bruining, HA; De Jong, FH; Hackeng, WH; Lamberts, SW; Marzouk, H; Uitterlinden, P; Zuiderwijk, J	1
Demers, LM; Hanagan, J; Harvey, HA; Lipton, A; Mulagha, M; Santen, RJ	1
Kimura, M; Nomura, Y; Ohashi, Y; Takashima, S; Toge, T; Tominaga, T	1
Angotti, M; Hartmann, RW; Müller-Vieira, U	1
Bissery, A; Gonzalez, MF; Guyene, TT; Ménard, J	1
Beugels, IP; Cohuet, GM; de Gooyer, ME; Emmen, JM; Hermans, JJ; Hilbers, PA; Minnaard-Huiban, M; Ottenheijm, HC; Pieterse, K; Plate, R; Roumen, L; Ruijters, E; Smits, JF; van Essen, H	1
Beil, M; Fu, F; Hu, CW; Jeng, AY; Liang, G; Rigel, DF	1
Ahmad, M; Ahmadi, S; Huang, BS; Leenen, FH; White, RA	1
Coleman, R; Gamliel-Lazarovich, A; Gantman, A; Jeng, AY; Kaplan, M; Keidar, S	1
Briones, AM; Callera, GE; He, Y; Montezano, AC; Nguyen Dinh Cat, A; Touyz, RM; Yogi, A	1
Arrowsmith, CH; Edwards, AM; Gilep, AA; Park, HW; Shen, L; Strushkevich, N; Usanov, SA	1
Kumagai, H; Nishida, Y; Oda, T; Onimaru, H; Oshima, N; Takechi, H; Uchida, T; Watanabe, A; Yamamoto, K	1
Brown, NJ	1
Ahmad, M; Huang, BS; Leenen, FH; White, RA	1
Hartmann, RW; Hu, Q; Yin, L	1
Ahmad, M; Chen, A; Huang, BS; Leenen, FH; Wang, HW; White, RA	1
Bornstein, SR; Brown, NF; Brunssen, C; Deussen, A; Eisenhofer, G; Engelmann, F; Hofmann, A; Huber, J; Jannasch, A; Martin, M; Mittag, J; Morawietz, H; Peitzsch, M; Streicher, R; Weldon, SM	1
Du, N; Du, Y; Gu, H; Kowala, MC; Ma, Z; Shatara, A; Wang, J; Yi, X; Zhu, T	1
Bornstein, SR; Brown, NF; Brunssen, C; Eisenhofer, G; Frenzel, A; Hofmann, A; Morawietz, H; Peitzsch, M; Weldon, SM; Willenberg, HS; Ziegler, CG	1
Korpela, R; Launonen, H; Linden, J; Luiskari, L; Salmenkari, H; Siltari, A; Vapaatalo, H	1
Groessl, M; Hafele, E; Kollar, J; Pignatti, E; Schumacher, C; Schuster, D; Steele, RE; Vogt, B	1

Reviews

1 review(s) available for fadrozole and aldosterone

Article	Year
Contribution of aldosterone to cardiovascular and renal inflammation and fibrosis. Nature reviews. Nephrology, 2013, Volume: 9, Issue:8 Topics: Aldosterone; Animals; Aromatase Inhibitors; Cardiovascular System; Cytochrome P-450 CYP11B2; Endothelial Cells; Fadrozole; Fibrosis; Humans; Imidazoles; Inflammation; Kidney; Macrophages; Mineralocorticoid Receptor Antagonists; Myocardium; Myocytes, Cardiac; Pyridines; Reactive Oxygen Species; Receptors, Mineralocorticoid; Sodium, Dietary	2013

Article

Year

Contribution of aldosterone to cardiovascular and renal inflammation and fibrosis.

Nature reviews. Nephrology, 2013, Volume: 9, Issue:8

Topics: Aldosterone; Animals; Aromatase Inhibitors; Cardiovascular System; Cytochrome P-450 CYP11B2; Endothelial Cells; Fadrozole; Fibrosis; Humans; Imidazoles; Inflammation; Kidney; Macrophages; Mineralocorticoid Receptor Antagonists; Myocardium; Myocytes, Cardiac; Pyridines; Reactive Oxygen Species; Receptors, Mineralocorticoid; Sodium, Dietary

2013

Trials

3 trial(s) available for fadrozole and aldosterone

Article	Year
The effects of fadrozole hydrochloride on aldosterone secretion in healthy male subjects. The Journal of clinical endocrinology and metabolism, 1992, Volume: 74, Issue:3 Topics: Adult; Aldosterone; Cosyntropin; Desoxycorticosterone; Double-Blind Method; Estradiol; Estrogen Antagonists; Estrone; Fadrozole; Furosemide; Humans; Hydrocortisone; Imidazoles; Nitriles; Posture; Reference Values; Renin	1992
The effects of long term fadrozole hydrochloride treatment in patients with advanced stage breast cancer. The Journal of steroid biochemistry and molecular biology, 1993, Volume: 44, Issue:4-6 Topics: Adrenocorticotropic Hormone; Aldosterone; Breast Neoplasms; Estradiol; Estrone; Fadrozole; Female; Humans; Hydrocortisone; Neoplasm Staging	1993
[A combined effect of fadrozole and tamoxifen in postmenopausal patients with recurrent breast cancer: a preliminary report: Japanese Cooperative Study Group of Fadrozole and Tamoxifen]. Gan to kagaku ryoho. Cancer & chemotherapy, 2000, Volume: 27, Issue:11 Topics: Aged; Aldosterone; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Administration Schedule; Fadrozole; Female; Humans; Middle Aged; Neoplasm Recurrence, Local; Postmenopause; Tamoxifen	2000

Other Studies

22 other study(ies) available for fadrozole and aldosterone

Article	Year
Specificity of low dose fadrozole hydrochloride (CGS 16949A) as an aromatase inhibitor. The Journal of clinical endocrinology and metabolism, 1991, Volume: 73, Issue:1 Topics: 17-alpha-Hydroxyprogesterone; Adrenocorticotropic Hormone; Aldosterone; Androstenedione; Aromatase Inhibitors; Breast Neoplasms; Estradiol; Estrone; Fadrozole; Female; Humans; Hydrocortisone; Hydroxyprogesterones; Imidazoles; Kinetics; Menopause; Nitriles	1991
Preliminary study of the treatment of advanced breast cancer in postmenopausal women with the aromatase inhibitor CGS 16949A. Cancer research, 1990, Mar-01, Volume: 50, Issue:5 Topics: Aldosterone; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Drug Evaluation; Electrolytes; Estradiol; Fadrozole; Female; Humans; Imidazoles; Menopause; Nitriles; Receptors, Estrogen	1990
The effects of CGS 16949A, an aromatase inhibitor on adrenal mineralocorticoid biosynthesis. The Journal of clinical endocrinology and metabolism, 1990, Volume: 70, Issue:4 Topics: 18-Hydroxycorticosterone; Adrenal Cortex; Adrenocorticotropic Hormone; Aged; Aldosterone; Aromatase Inhibitors; Binding Sites; Breast Neoplasms; Chemical Phenomena; Chemistry; Cytochrome P-450 CYP11B2; Cytochrome P-450 Enzyme Inhibitors; Electrolytes; Fadrozole; Female; Humans; Hydrocortisone; Imidazoles; In Vitro Techniques; Mineralocorticoids; Mixed Function Oxygenases; Nitriles	1990
Evidence that corticosterone is not an obligatory intermediate in aldosterone biosynthesis in the rat adrenal. Journal of steroid biochemistry, 1989, Volume: 34, Issue:1-6 Topics: Adrenal Glands; Aldosterone; Aminoglutethimide; Animals; Aromatase Inhibitors; Corticosterone; Cosyntropin; Delayed-Action Preparations; Desoxycorticosterone; Fadrozole; Imidazoles; In Vitro Techniques; Male; Nitriles; Rats; Rats, Inbred Strains	1989
The new aromatase inhibitor CGS-16949A suppresses aldosterone and cortisol production by human adrenal cells in vitro. The Journal of clinical endocrinology and metabolism, 1989, Volume: 69, Issue:4 Topics: Adrenal Cortex; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Aldosterone; Aromatase Inhibitors; Cells, Cultured; Fadrozole; Female; Humans; Hydrocortisone; Imidazoles; Kinetics; Male; Nitriles	1989
The adrenocortical tumor cell line NCI-H295R as an in vitro screening system for the evaluation of CYP11B2 (aldosterone synthase) and CYP11B1 (steroid-11beta-hydroxylase) inhibitors. The Journal of steroid biochemistry and molecular biology, 2005, Volume: 96, Issue:3-4 Topics: Adrenal Cortex; Aldosterone; Aromatase Inhibitors; Cell Line, Tumor; Cytochrome P-450 CYP11B2; Drug Evaluation, Preclinical; Enzyme Inhibitors; Fadrozole; Humans; Steroid 11-beta-Hydroxylase; Steroids	2005
Investigation of aldosterone-synthase inhibition in rats. Journal of hypertension, 2006, Volume: 24, Issue:6 Topics: Aldosterone; Animals; Blood Pressure; Body Weight; Cytochrome P-450 CYP11B2; Diuretics; Dose-Response Relationship, Drug; Drug Interactions; Fadrozole; Furosemide; Hypokalemia; Male; Mineralocorticoid Receptor Antagonists; Potassium; Potassium, Dietary; Rats; Rats, Inbred SHR; Renin-Angiotensin System; Sodium; Sodium, Dietary; Urea	2006
Fadrozole reverses cardiac fibrosis in spontaneously hypertensive heart failure rats: discordant enantioselectivity versus reduction of plasma aldosterone. Endocrinology, 2008, Volume: 149, Issue:1 Topics: Aldosterone; Animals; Canrenoic Acid; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type III; Drug Evaluation, Preclinical; Fadrozole; Fibrosis; Gene Expression Regulation; Heart; Heart Failure; Male; Mineralocorticoid Receptor Antagonists; Myocardium; Rats; Rats, Inbred SHR; Stereoisomerism; Structure-Activity Relationship; Treatment Outcome	2008
Pharmacodynamic and pharmacokinetic characterization of the aldosterone synthase inhibitor FAD286 in two rodent models of hyperaldosteronism: comparison with the 11beta-hydroxylase inhibitor metyrapone. The Journal of pharmacology and experimental therapeutics, 2010, Volume: 334, Issue:1 Topics: Adrenal Glands; Aldosterone; Animals; Blood Pressure; Blood Proteins; Chromatography, Liquid; Corticosterone; Cytochrome P-450 CYP11B2; Disease Models, Animal; Enzyme Inhibitors; Fadrozole; Hyperaldosteronism; Imidazoles; In Vitro Techniques; Male; Mass Spectrometry; Metyrapone; Protein Binding; Pyridines; Rats; Rats, Sprague-Dawley; Steroid 11-beta-Hydroxylase	2010
Central neuronal activation and pressor responses induced by circulating ANG II: role of the brain aldosterone-"ouabain" pathway. American journal of physiology. Heart and circulatory physiology, 2010, Volume: 299, Issue:2 Topics: Aldosterone; Angiotensin II; Animals; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Brain; Cardenolides; Cytochrome P-450 CYP11B2; Enzyme Inhibitors; Fadrozole; Heart Rate; Hypothalamus; Imidazoles; Immunoglobulin Fab Fragments; Immunohistochemistry; Infusion Pumps, Implantable; Infusions, Parenteral; Infusions, Subcutaneous; Male; Mineralocorticoid Receptor Antagonists; Neural Pathways; Neurons; Proto-Oncogene Proteins c-fos; Pyridines; Rats; Rats, Wistar; Renin-Angiotensin System; Saponins; Spironolactone; Subfornical Organ; Telemetry; Time Factors	2010
FAD286, an aldosterone synthase inhibitor, reduced atherosclerosis and inflammation in apolipoprotein E-deficient mice. Journal of hypertension, 2010, Volume: 28, Issue:9 Topics: Aldosterone; Animals; Apolipoproteins E; Atherosclerosis; Cell Line; Cytochrome P-450 CYP11B2; Diet, Sodium-Restricted; Enzyme Inhibitors; Fadrozole; Imidazoles; Inflammation; Macrophages; Male; Mice; Mice, Knockout; Pyridines	2010
Adipocyte-derived factors regulate vascular smooth muscle cells through mineralocorticoid and glucocorticoid receptors. Hypertension (Dallas, Tex. : 1979), 2011, Volume: 58, Issue:3 Topics: 3T3-L1 Cells; Adipocytes; Aldosterone; Angiotensin II; Animals; Blotting, Western; Cells, Cultured; Corticosterone; Culture Media, Conditioned; Eplerenone; Fadrozole; Fibronectins; Hormone Antagonists; Mice; Mice, Inbred C57BL; Mifepristone; Mineralocorticoid Receptor Antagonists; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins c-bcl-2; Receptor, Angiotensin, Type 1; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Spironolactone	2011
Structural insights into aldosterone synthase substrate specificity and targeted inhibition. Molecular endocrinology (Baltimore, Md.), 2013, Volume: 27, Issue:2 Topics: Aldosterone; Blood Pressure; Catalysis; Crystallography, X-Ray; Cytochrome P-450 CYP11B2; Desoxycorticosterone; Fadrozole; Humans; Hypertension; Models, Molecular; Protein Structure, Tertiary; Renin-Angiotensin System; Steroid 11-beta-Hydroxylase; Substrate Specificity; Water-Electrolyte Balance	2013
Aldosterone is synthesized in and activates bulbospinal neurons through mineralocorticoid receptors and ENaCs in the RVLM. Hypertension research : official journal of the Japanese Society of Hypertension, 2013, Volume: 36, Issue:6 Topics: Aldosterone; Amiloride; Animals; Aromatase Inhibitors; Calcium; Diuretics; Epithelial Sodium Channels; Eplerenone; Excitatory Postsynaptic Potentials; Fadrozole; Magnesium; Medulla Oblongata; Membrane Potentials; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Mineralocorticoid; Spinal Cord; Spironolactone; Tissue Fixation	2013
Role of brain corticosterone and aldosterone in central angiotensin II-induced hypertension. Hypertension (Dallas, Tex. : 1979), 2013, Volume: 62, Issue:3 Topics: Aldosterone; Angiotensin II; Animals; Blood Pressure; Brain; Corticosterone; Cytochrome P-450 CYP11B2; Dose-Response Relationship, Drug; Eplerenone; Fadrozole; Heart Rate; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptors, Mineralocorticoid; Spironolactone	2013
Aldosterone synthase inhibitors as promising treatments for mineralocorticoid dependent cardiovascular and renal diseases. Journal of medicinal chemistry, 2014, Jun-26, Volume: 57, Issue:12 Topics: Aldosterone; Animals; Benzimidazoles; Cardiovascular Diseases; Cytochrome P-450 CYP11B2; Fadrozole; Humans; Indans; Indoles; Kidney Diseases; Mineralocorticoids; Naphthalenes; Quinolines; Receptors, Mineralocorticoid	2014
Role of brain aldosterone and mineralocorticoid receptors in aldosterone-salt hypertension in rats. Neuroscience, 2016, Feb-09, Volume: 314 Topics: Aldosterone; Animals; Arterial Pressure; Corticosterone; Cytochrome P-450 CYP11B2; Drinking Behavior; Eplerenone; Fadrozole; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Neurons; Paraventricular Hypothalamic Nucleus; Rats; Rats, Wistar; Receptors, Mineralocorticoid; RNA, Messenger; Sodium Chloride; Spironolactone; Subfornical Organ; Supraoptic Nucleus	2016
Aldosterone Synthase Inhibition Improves Glucose Tolerance in Zucker Diabetic Fatty (ZDF) Rats. Endocrinology, 2016, Volume: 157, Issue:10 Topics: Adrenal Glands; Aldosterone; Animals; Blood Glucose; Body Weight; Cytochrome P-450 CYP11B2; Diabetes Mellitus, Type 2; Disease Models, Animal; Drug Evaluation, Preclinical; Eating; Eplerenone; Fadrozole; Glucose Tolerance Test; Glycated Hemoglobin; Insulin; Insulin Resistance; Insulin Secretion; Liver; Male; Mineralocorticoid Receptor Antagonists; Organ Size; Potassium; Random Allocation; Rats, Zucker; Sodium; Spironolactone; Triglycerides	2016
Salt-dependent Blood Pressure in Human Aldosterone Synthase-Transgenic Mice. Scientific reports, 2017, 03-28, Volume: 7, Issue:1 Topics: Aldosterone; Animals; Biomarkers; Blood Pressure; Cytochrome P-450 CYP11B2; Electrolytes; Fadrozole; Gene Expression; Genotype; Hematocrit; Humans; Hypertension; Kidney; Mice; Mice, Transgenic; Phenotype; Renin; Sodium Chloride, Dietary; Steroid 11-beta-Hydroxylase	2017
Impact of Aldosterone Synthase Inhibitor FAD286 on Steroid Hormone Profile in Human Adrenocortical Cells. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2017, Volume: 49, Issue:9 Topics: Adrenal Cortex; Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Biphenyl Compounds; Cell Line; Cytochrome P-450 CYP11B2; Enzyme Inhibitors; Fadrozole; Gene Expression Regulation, Enzymologic; Glucocorticoids; Hormones; Humans; Receptor, Angiotensin, Type 1; RNA, Messenger; Steroids; Tetrazoles	2017
Adverse effects of an aldosterone synthase (CYP11B2) inhibitor, fadrozole (FAD286), on inflamed rat colon. Basic & clinical pharmacology & toxicology, 2023, Volume: 133, Issue:3 Topics: Aldosterone; Animals; Colon; Cytochrome P-450 CYP11B2; Fadrozole; Iatrogenic Disease; Inflammation; Mice; Rats; Rats, Sprague-Dawley	2023
Structural and clinical characterization of CYP11B2 inhibition by dexfadrostat phosphate. The Journal of steroid biochemistry and molecular biology, 2023, Volume: 235 Topics: Aldosterone; Corticosterone; Cytochrome P-450 CYP11B2; Fadrozole; Humans; Phosphates; Steroid 11-beta-Hydroxylase	2023