Page last updated: 2024-09-03

ezogabine and xe 991, anthracenone

ezogabine has been researched along with xe 991, anthracenone in 60 studies

Compound Research Comparison

Studies (ezogabine)	Trials (ezogabine)	Recent Studies (post-2010) (ezogabine)	Studies (xe 991, anthracenone)	Trials (xe 991, anthracenone)	Recent Studies (post-2010) (xe 991, anthracenone)
383	26	241	150	0	82

Protein Interaction Comparison

Protein	Taxonomy	ezogabine (IC50)	xe 991, anthracenone (IC50)
Potassium voltage-gated channel subfamily KQT member 2	Homo sapiens (human)		0.055

Research

Studies (60)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	25 (41.67)	29.6817
2010's	34 (56.67)	24.3611
2020's	1 (1.67)	2.80

Authors

Authors	Studies
Christensen, JK; Christophersen, P; Dupuis, DS; Jensen, BS; Jespersen, T; Olesen, SP; Schrøder, RL	1
Blackburn-Munro, G; Jensen, BS	1
Crankshaw, DJ; Scott, CW; Trivedi, S; Wilkins, DE	1
Al-Qatari, M; Brown, DA; Brown, TA; Burbidge, SA; Dickenson, AH; Main, M; Marsh, SJ; Matthews, EA; Mistry, M; Passmore, GM; Selyanko, AA	1
Annunziato, L; Castaldo, P; D'Amico, M; Martire, M; Preziosi, P; Taglialatela, M	1
Lopez-Garcia, JA; Martinez-Gomez, J; Rivera-Arconada, I	1
Yaari, Y; Yue, C	1
Lopez-Garcia, JA; Rivera-Arconada, I	2
Brown, JT; Piccinin, S; Randall, AD	1
Ebbesen, C; Hansen, HH; Mathiesen, C; Mikkelsen, JD; Rønn, LC; Scuvée-Moreau, J; Seutin, V; Waroux, O; Weikop, P	1
Agdestein, C; Gu, N; Hu, H; Storm, JF; Vervaeke, K	1
Churchill, JF; Lawrence, JJ; McBain, CJ; Saraga, F; Skinner, FK; Statland, JM; Travis, KE	1
Hu, H; Storm, JF; Vervaeke, K	1
Calloe, K; Elmedyb, P; Grunnet, M; Hansen, RS; Olesen, SP; Schmitt, N	1
Greenwood, IA; Moffatt, JD; Ohya, S; Pucovský, V; Saldanha, L; Schwake, M; Yeung, SY	1
Feng, B; Glazebrook, PA; Kunze, DL; Schild, JH; Wladyka, CL	1
Brown, DA; Fleckenstein, J; Grafe, P; Lang, PM; Passmore, GM	1
Greenwood, Ia; Pucovský, V; Schwake, M; Yeung, S	1
Andersson, M; Baines, DL; Greenwood, IA; Hettiarachi, S; Yeung, SY	1
Greenwood, IA; McCallum, LA; Tribe, RM	1
Bundgaard, C; Damgaard, T; Husum, H; Montezinho, LP; Mørk, A; Olsen, CK; Sotty, F	1
Brown, JT; Randall, AD	1
Greenwood, IA; Jepps, TA; Moffatt, JD; Ohya, S; Sanders, KM	1
Boehlen, A; Heinemann, U; Kunert, A	1
Barrese, V; Iannotti, FA; Panza, E; Soldovieri, MV; Taglialatela, M; Viggiano, D	1
England, SK; Greenwood, IA; McCallum, LA; Pierce, SL; Tribe, RM	1
Rode, F; Rønn, LC; Sheykhzade, M; Svalø, J	1
Crean, CS; Dubrovska, G; Gloe, T; Gollasch, M; Huang, Y; Köhn, C; Luft, FC; Schleifenbaum, J; Schubert, R; Voblova, N; Zavarirskaya, O	1
Bi, Y; Gan, Y; Tan, L; Wang, K; Wu, Y; Xu, W	1
Hansen, HH; Kristensen, LV; Sandager-Nielsen, K	1
Hansen, HH; Jensen, MM; Lange, SC; Mikkelsen, JD; Thomsen, MS	1
Baraban, SC; Chege, SW; Hortopan, GA; T Dinday, M	1
Hansen, HH; Munro, G; Rode, F; Rønn, LC; Sheykhzade, M; Svalø, J	1
Cavaliere, S; Hodge, JJ	1
Brueggemann, LI; Byron, KL; Cribbs, LL; Dowell, ML; Kakad, PP; Love, RB; Solway, J	1
Bi, Y; Bian, X; Cao, X; Chen, H; Su, J; Wang, K	1
Brueggemann, LI; Byron, KL; Kumar, L; Mani, BK; O'Dowd, J; Ross, M	1
Cai, J; Fang, D; Han, JS; Liu, M; Wan, Y; Xing, GG; Zheng, Q	1
Gamper, N; Gigout, S; Ooi, L; Pettinger, L	1
King, AE; Visockis, V	1
Brown, DA; Marsh, SJ; Passmore, GM; Reilly, JM; Telezhkin, V	1
Chen, F; Gao, ZB; Hu, HN; Li, M; Nan, FJ; Zhou, PZ	1
Afeli, SA; Malysz, J; Petkov, GV	1
Adduci, A; Arena, V; Coco, C; Currò, D; Martire, M; Rizzo, G; Taglialatela, M	1
Brueggemann, LI; Byron, KL; Cribbs, LL; Haick, JM; Neuburg, S; Randhawa, D; Tate, S	1
Hayashi, H; Iwata, M; Matsumoto, T; Tsuchimori, N	1
Davies, KP; Fu, S; Melman, A; Tar, MT; Wang, Y	1
Guo, L; Huang, P; Li, C; Lu, Q; Xu, X; Zhou, M	1
Cai, J; Fang, D; Li, S; Liu, XD; Ren, J; Xing, GG	1
Bierbower, SM; Choveau, FS; Lechleiter, JD; Shapiro, MS	1
Budde, T; Cerina, M; Coulon, P; Göbel, K; Kanyshkova, T; Meuth, P; Meuth, SG; Nguyen, XV; Pape, HC; Seidenbecher, T; Szkudlarek, HJ	1
Chesler, EJ; Gass, JT; Griffin, WC; McGuier, NS; Mulholland, PJ; Padula, AE	1
Greene, DL; Hoshi, N; Kang, S; Kay, HY; Kosenko, A	1
Li, G; Ma, TY; Qi, JL; Song, Y; Teng, BC; Wang, K; Zhang, F; Zhang, HL	1
Apostolova, E; Kokova, V; Peychev, L; Zagorchev, P	1
Greene, DL; Hoshi, N; Kang, S	1
Holt, JC; Jones, TA; Lee, C	1
Lee, LY; Lin, AH; Meeker, S; Patil, MJ; Ru, F; Sun, H; Undem, BJ	1
Deyama, S; Esaki, H; Fukao, A; Izumi, S; Kaneda, K; Nishitani, N	1

Other Studies

60 other study(ies) available for ezogabine and xe 991, anthracenone

Article	Year
Activation of KCNQ5 channels stably expressed in HEK293 cells by BMS-204352. European journal of pharmacology, 2002, Feb-22, Volume: 437, Issue:3 Topics: Anthracenes; Carbamates; Cell Line; Dose-Response Relationship, Drug; Gene Expression; Humans; Indoles; KCNQ Potassium Channels; Membrane Potentials; Phenylenediamines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines	2002
The anticonvulsant retigabine attenuates nociceptive behaviours in rat models of persistent and neuropathic pain. European journal of pharmacology, 2003, Jan-24, Volume: 460, Issue:2-3 Topics: Animals; Anthracenes; Anticonvulsants; Behavior, Animal; Carbamates; Disease Models, Animal; Dose-Response Relationship, Drug; Hindlimb; Male; Neuralgia; Pain Measurement; Phenylenediamines; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Time Factors	2003
A medium-throughput functional assay of KCNQ2 potassium channels using rubidium efflux and atomic absorption spectrometry. Analytical biochemistry, 2003, Aug-15, Volume: 319, Issue:2 Topics: Anthracenes; Carbamates; Cell Line; Clone Cells; Dose-Response Relationship, Drug; Humans; Indoles; KCNQ2 Potassium Channel; Kinetics; Phenylenediamines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Potassium Chloride; Pyridines; Quaternary Ammonium Compounds; Rubidium; Spectrophotometry, Atomic; Tetraethylammonium; Transfection	2003
KCNQ/M currents in sensory neurons: significance for pain therapy. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Aug-06, Volume: 23, Issue:18 Topics: Animals; Anthracenes; Anura; Carbamates; Cells, Cultured; CHO Cells; Cricetinae; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Indoles; Male; Neurons, Afferent; Oocytes; Pain; Pain Management; Pain Measurement; Patch-Clamp Techniques; Phenylenediamines; Potassium Channel Blockers; Potassium Channels; Pyridines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Transfection	2003
M channels containing KCNQ2 subunits modulate norepinephrine, aspartate, and GABA release from hippocampal nerve terminals. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Jan-21, Volume: 24, Issue:3 Topics: Aminopyridines; Animals; Anthracenes; Anticonvulsants; Aspartic Acid; Carbamates; CHO Cells; Cricetinae; gamma-Aminobutyric Acid; Hippocampus; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Male; Norepinephrine; Patch-Clamp Techniques; Phenylenediamines; Potassium; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Presynaptic Terminals; Protein Subunits; Rats; Synaptosomes	2004
M-current modulators alter rat spinal nociceptive transmission: an electrophysiological study in vitro. Neuropharmacology, 2004, Volume: 46, Issue:4 Topics: Animals; Anthracenes; Carbamates; Electrophysiology; Female; In Vitro Techniques; Male; Nerve Fibers; Pain Measurement; Phenylenediamines; Potassium Channels, Voltage-Gated; Rats; Rats, Wistar; Spinal Cord; Synaptic Transmission	2004
KCNQ/M channels control spike afterdepolarization and burst generation in hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, May-12, Volume: 24, Issue:19 Topics: Action Potentials; Animals; Anthracenes; Carbamates; Hippocampus; In Vitro Techniques; Indoles; Neurons; Phenylenediamines; Potassium; Potassium Channel Blockers; Potassium Channels; Pyramidal Cells; Pyridines; Rats	2004
Effects of M-current modulators on the excitability of immature rat spinal sensory and motor neurones. The European journal of neuroscience, 2005, Volume: 22, Issue:12 Topics: Action Potentials; Analysis of Variance; Animals; Animals, Newborn; Anthracenes; Anticonvulsants; Carbamates; Dose-Response Relationship, Radiation; Electric Stimulation; Female; In Vitro Techniques; Male; Membrane Potentials; Motor Neurons; Neurons, Afferent; Phenylenediamines; Potassium Channels, Voltage-Gated; Rats; Reaction Time; Spinal Cord; Synaptic Transmission; Time Factors	2005
KCNQ/Kv7 channel regulation of hippocampal gamma-frequency firing in the absence of synaptic transmission. Journal of neurophysiology, 2006, Volume: 95, Issue:5 Topics: Action Potentials; Animals; Anthracenes; Calcium; Carbamates; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Hippocampus; In Vitro Techniques; Indoles; KCNQ Potassium Channels; Male; Neurons; Periodicity; Phenylenediamines; Potassium; Potassium Channel Blockers; Pyridines; Rats; Synaptic Transmission	2006
The KCNQ channel opener retigabine inhibits the activity of mesencephalic dopaminergic systems of the rat. The Journal of pharmacology and experimental therapeutics, 2006, Volume: 318, Issue:3 Topics: Animals; Anthracenes; Carbamates; Dopamine; Dopamine Antagonists; Haloperidol; KCNQ Potassium Channels; Male; Mesencephalon; Phenylenediamines; Phosphorylation; Protein Subunits; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Substantia Nigra; Tyrosine 3-Monooxygenase; Ventral Tegmental Area	2006
Kv7/KCNQ/M-channels in rat glutamatergic hippocampal axons and their role in regulation of excitability and transmitter release. The Journal of physiology, 2006, Oct-01, Volume: 576, Issue:Pt 1 Topics: 4-Aminopyridine; Action Potentials; Animals; Anthracenes; Anticonvulsants; Axons; Carbamates; Electrophysiology; Excitatory Postsynaptic Potentials; Hippocampus; KCNQ Potassium Channels; Male; Models, Theoretical; Phenylenediamines; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Rats; Rats, Wistar; Synaptic Transmission	2006
Retigabine-induced population primary afferent hyperpolarisation in vitro. Neuropharmacology, 2006, Volume: 51, Issue:4 Topics: Action Potentials; Afferent Pathways; Animals; Animals, Newborn; Anthracenes; Anticonvulsants; Carbamates; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; Ganglia, Spinal; Glutamates; In Vitro Techniques; Male; Phenylenediamines; Picrotoxin; Rats; Rats, Wistar; Spinal Cord	2006
Somatodendritic Kv7/KCNQ/M channels control interspike interval in hippocampal interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Nov-22, Volume: 26, Issue:47 Topics: Action Potentials; Animals; Anthracenes; Carbamates; Cell Line; Computer Simulation; Dendrites; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Green Fluorescent Proteins; Hippocampus; Humans; Immunohistochemistry; In Vitro Techniques; Indoles; Interneurons; KCNQ Potassium Channels; Membrane Potentials; Mice; Mice, Transgenic; Models, Neurological; Patch-Clamp Techniques; Phenylenediamines; Potassium Channel Blockers; Pyridines; Tetraethylammonium; Transfection	2006
M-channels (Kv7/KCNQ channels) that regulate synaptic integration, excitability, and spike pattern of CA1 pyramidal cells are located in the perisomatic region. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, Feb-21, Volume: 27, Issue:8 Topics: Action Potentials; Animals; Anthracenes; Calcium; Carbamates; Cerebral Cortex; Computer Simulation; Dendrites; Electrophysiology; Excitatory Postsynaptic Potentials; Extracellular Space; In Vitro Techniques; Indoles; KCNQ Potassium Channels; Male; Models, Neurological; Patch-Clamp Techniques; Phenylenediamines; Potassium Channel Blockers; Pyramidal Cells; Pyridines; Rats; Rats, Wistar; Synapses; Tissue Distribution	2007
Modulation of ERG channels by XE991. Basic & clinical pharmacology & toxicology, 2007, Volume: 100, Issue:5 Topics: Acetylcholine; Animals; Anthracenes; Carbamates; Cell Line; Chromans; Dose-Response Relationship, Drug; Electrophysiology; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Gene Expression; Indoles; Oocytes; Patch-Clamp Techniques; Phenylenediamines; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Pyridines; Xenopus laevis	2007
Molecular expression and pharmacological identification of a role for K(v)7 channels in murine vascular reactivity. British journal of pharmacology, 2007, Volume: 151, Issue:6 Topics: Aminopyridines; Animals; Anthracenes; Carbamates; Dose-Response Relationship, Drug; Gene Expression Profiling; Immunohistochemistry; Indoles; Isometric Contraction; KCNQ Potassium Channels; KCNQ1 Potassium Channel; Meclofenamic Acid; Mice; Mice, Inbred BALB C; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phenylenediamines; Potassium Channel Blockers; Potassium Channels; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA	2007
The KCNQ/M-current modulates arterial baroreceptor function at the sensory terminal in rats. The Journal of physiology, 2008, Feb-01, Volume: 586, Issue:3 Topics: Animals; Anthracenes; Anticonvulsants; Aorta, Thoracic; Carbamates; KCNQ Potassium Channels; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Male; Membrane Potentials; Neurons, Afferent; Nodose Ganglion; Patch-Clamp Techniques; Phenylenediamines; Pressoreceptors; Presynaptic Terminals; Rats; Rats, Sprague-Dawley	2008
Retigabine reduces the excitability of unmyelinated peripheral human axons. Neuropharmacology, 2008, Volume: 54, Issue:8 Topics: Action Potentials; Aged; Aged, 80 and over; Anthracenes; Anticonvulsants; Axons; Carbamates; Electrophysiology; Female; Humans; In Vitro Techniques; Male; Middle Aged; Nerve Fibers, Unmyelinated; Patch-Clamp Techniques; Peripheral Nerves; Phenylenediamines; Sural Nerve; Tachyphylaxis	2008
Bimodal effects of the Kv7 channel activator retigabine on vascular K+ currents. British journal of pharmacology, 2008, Volume: 155, Issue:1 Topics: Aminopyridines; Animals; Anthracenes; Carbamates; Dose-Response Relationship, Drug; In Vitro Techniques; KCNQ Potassium Channels; KCNQ1 Potassium Channel; Membrane Potentials; Mice; Mice, Inbred BALB C; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phenylenediamines; Portal Vein; Potassium; Potassium Channel Blockers; Recombinant Proteins; RNA, Messenger; Time Factors; Vasoconstriction; Vasodilator Agents; Xenopus laevis	2008
KCNQ-encoded channels regulate Na+ transport across H441 lung epithelial cells. Pflugers Archiv : European journal of physiology, 2009, Volume: 457, Issue:4 Topics: Anthracenes; Anticonvulsants; Brain; Carbamates; Cell Line; Epithelial Cells; Humans; KCNQ Potassium Channels; Lung; Myocardium; Peptides; Phenylenediamines; Potassium Channel Blockers; Protein Isoforms; Sodium	2009
Expression and function of K(v)7 channels in murine myometrium throughout oestrous cycle. Pflugers Archiv : European journal of physiology, 2009, Volume: 457, Issue:5 Topics: Animals; Anthracenes; Carbamates; Chromans; Estrous Cycle; Female; KCNQ1 Potassium Channel; Mice; Mice, Inbred C57BL; Myometrium; Phenylenediamines; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Sulfonamides; Uterine Contraction	2009
Antipsychotic-like effect of retigabine [N-(2-Amino-4-(fluorobenzylamino)-phenyl)carbamic acid ester], a KCNQ potassium channel opener, via modulation of mesolimbic dopaminergic neurotransmission. The Journal of pharmacology and experimental therapeutics, 2009, Volume: 328, Issue:3 Topics: Animals; Anthracenes; Antipsychotic Agents; Carbamates; Dopamine; KCNQ Potassium Channels; Limbic System; Male; Microdialysis; Nucleus Accumbens; Phenylenediamines; Rats; Rats, Wistar; Synaptic Transmission	2009
Activity-dependent depression of the spike after-depolarization generates long-lasting intrinsic plasticity in hippocampal CA3 pyramidal neurons. The Journal of physiology, 2009, Mar-15, Volume: 587, Issue:Pt 6 Topics: Action Potentials; Animals; Anthracenes; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Signaling; Carbamates; Cardiovascular Agents; Chelating Agents; Egtazic Acid; Hippocampus; In Vitro Techniques; KCNQ Potassium Channels; Male; Membrane Potentials; Neuronal Plasticity; Patch-Clamp Techniques; Phenylenediamines; Pyramidal Cells; Pyrimidines; Rats; Rats, Wistar	2009
Molecular and functional characterization of Kv7 K+ channel in murine gastrointestinal smooth muscles. American journal of physiology. Gastrointestinal and liver physiology, 2009, Volume: 297, Issue:1 Topics: Animals; Anthracenes; Blotting, Western; Carbamates; Chromans; Colon; Gastrointestinal Tract; Immunohistochemistry; Indoles; KCNQ Potassium Channels; KCNQ1 Potassium Channel; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Myography; Phenylenediamines; Potassium Channel Blockers; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides	2009
Effects of XE991, retigabine, losigamone and ZD7288 on kainate-induced theta-like and gamma network oscillations in the rat hippocampus in vitro. Brain research, 2009, Oct-27, Volume: 1295 Topics: Animals; Anthracenes; Anticonvulsants; Biological Clocks; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Carbamates; Electrophysiology; Excitatory Amino Acid Agonists; Furans; Kainic Acid; Membrane Potentials; Nerve Net; Neurons; Periodicity; Phenylenediamines; Pyrimidines; Rats; Rats, Wistar	2009
Expression, localization, and pharmacological role of Kv7 potassium channels in skeletal muscle proliferation, differentiation, and survival after myotoxic insults. The Journal of pharmacology and experimental therapeutics, 2010, Volume: 332, Issue:3 Topics: Adult; Animals; Anthracenes; Carbamates; Cell Differentiation; Cell Line; Cell Proliferation; Cell Survival; Cricetinae; Cricetulus; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; KCNQ Potassium Channels; KCNQ1 Potassium Channel; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Lovastatin; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Myoblasts, Skeletal; Phenylenediamines; Protein Subunits; RNA, Messenger; Up-Regulation	2010
The contribution of Kv7 channels to pregnant mouse and human myometrial contractility. Journal of cellular and molecular medicine, 2011, Volume: 15, Issue:3 Topics: Aminopyridines; Animals; Anthracenes; Anticonvulsants; Carbamates; Female; Gene Expression; Gestational Age; Humans; KCNQ Potassium Channels; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Myometrium; Phenylenediamines; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Pregnancy; Protein Isoforms; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Uterine Contraction	2011
Functional effects of the KCNQ modulators retigabine and XE991 in the rat urinary bladder. European journal of pharmacology, 2010, Jul-25, Volume: 638, Issue:1-3 Topics: Animals; Anthracenes; Anticonvulsants; Carbachol; Carbamates; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; In Vitro Techniques; KCNQ Potassium Channels; Muscle Contraction; Phenylenediamines; Potassium Channel Blockers; Potassium Chloride; Rats; Rats, Sprague-Dawley; Urinary Bladder	2010
Systemic peripheral artery relaxation by KCNQ channel openers and hydrogen sulfide. Journal of hypertension, 2010, Volume: 28, Issue:9 Topics: Adipose Tissue; Animals; Anthracenes; Aorta; Arteries; Carbamates; Hydrogen Sulfide; In Vitro Techniques; Isometric Contraction; KCNQ Potassium Channels; Male; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Paracrine Communication; Phenylenediamines; Rats; Rats, Sprague-Dawley; Vasodilation	2010
Activation of voltage-gated KCNQ/Kv7 channels by anticonvulsant retigabine attenuates mechanical allodynia of inflammatory temporomandibular joint in rats. Molecular pain, 2010, Aug-27, Volume: 6 Topics: Analgesia; Animals; Anthracenes; Anticonvulsants; Carbamates; Feeding Behavior; Freund's Adjuvant; Hyperalgesia; Inflammation; Injections, Intraventricular; Ion Channel Gating; KCNQ Potassium Channels; Male; Phenylenediamines; Rats; Rats, Sprague-Dawley; Temporomandibular Joint	2010
Kv7 (KCNQ) channel openers induce hypothermia in the mouse. Neuroscience letters, 2011, Jan-20, Volume: 488, Issue:2 Topics: Animals; Anthracenes; Anticonvulsants; Benzamides; Body Temperature Regulation; Carbamates; Female; Hypothermia; Indoles; KCNQ Potassium Channels; Mice; Phenylenediamines; Protein Isoforms; Pyridines	2011
The pharmacological effect of positive KCNQ (Kv7) modulators on dopamine release from striatal slices. Basic & clinical pharmacology & toxicology, 2011, Volume: 109, Issue:5 Topics: Animals; Anthracenes; Anticonvulsants; Benzamides; Carbamates; Dopamine; Dopamine Antagonists; In Vitro Techniques; Indoles; Inhibitory Concentration 50; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Male; Mesencephalon; Neostriatum; Neurons; Nonlinear Dynamics; Phenylenediamines; Potassium Channel Blockers; Potassium Chloride; Pyridines; Rats; Rats, Wistar; Regression Analysis	2011
Expression and function of KCNQ channels in larval zebrafish. Developmental neurobiology, 2012, Volume: 72, Issue:2 Topics: Action Potentials; Analysis of Variance; Animals; Anthracenes; Anticonvulsants; Brain; Carbamates; Dose-Response Relationship, Drug; Electrophysiology; Gene Expression Regulation, Developmental; Indoles; KCNQ Potassium Channels; Larva; Locomotion; Morpholinos; Phenylenediamines; Potassium Channel Blockers; Pyridines; RNA, Messenger; Swimming; Zebrafish	2012
Kv 7 positive modulators reduce detrusor overactivity and increase bladder capacity in rats. Basic & clinical pharmacology & toxicology, 2012, Volume: 110, Issue:2 Topics: Animals; Anthracenes; Capsaicin; Carbamates; Female; KCNQ Potassium Channels; Phenylenediamines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Urinary Bladder; Urinary Bladder, Overactive	2012
Drosophila KCNQ channel displays evolutionarily conserved electrophysiology and pharmacology with mammalian KCNQ channels. PloS one, 2011, Volume: 6, Issue:9 Topics: Animals; Anthracenes; Carbamates; Cell Line; Chromans; Drosophila; Drosophila Proteins; Electrophysiology; Humans; Indoles; KCNQ Potassium Channels; KCNQ1 Potassium Channel; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Organometallic Compounds; Patch-Clamp Techniques; Phenylenediamines; Pyridines; Sulfonamides	2011
Kv7 potassium channels in airway smooth muscle cells: signal transduction intermediates and pharmacological targets for bronchodilator therapy. American journal of physiology. Lung cellular and molecular physiology, 2012, Jan-01, Volume: 302, Issue:1 Topics: Aminopyridines; Animals; Anthracenes; Bronchoconstriction; Bronchodilator Agents; Calcium Channel Blockers; Carbamates; Celecoxib; Guinea Pigs; Histamine; Humans; KCNQ Potassium Channels; Male; Methacholine Chloride; Myocytes, Smooth Muscle; Patch-Clamp Techniques; Phenylenediamines; Pyrazoles; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sulfonamides; Verapamil	2012
Visceral hyperalgesia induced by forebrain-specific suppression of native Kv7/KCNQ/M-current in mice. Molecular pain, 2011, Oct-26, Volume: 7 Topics: Animals; Anthracenes; Capsaicin; Carbamates; Hyperalgesia; KCNQ2 Potassium Channel; Magnesium Sulfate; Mice; Mice, Transgenic; Phenylenediamines; Prosencephalon; Proto-Oncogene Proteins c-fos; Somatosensory Cortex; Visceral Pain	2011
Vascular KCNQ (Kv7) potassium channels as common signaling intermediates and therapeutic targets in cerebral vasospasm. Journal of cardiovascular pharmacology, 2013, Volume: 61, Issue:1 Topics: Animals; Anthracenes; Arginine Vasopressin; Basilar Artery; Carbamates; Celecoxib; Disease Models, Animal; Endothelin-1; KCNQ Potassium Channels; Male; Membrane Transport Modulators; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Myography; Patch-Clamp Techniques; Phenylenediamines; Potassium Channel Blockers; Pyrazoles; Rats; Rats, Sprague-Dawley; Serotonin; Signal Transduction; Subarachnoid Hemorrhage; Sulfonamides; Time Factors; Vasoconstriction; Vasoconstrictor Agents; Vasospasm, Intracranial	2013
Suppression of KCNQ/M (Kv7) potassium channels in dorsal root ganglion neurons contributes to the development of bone cancer pain in a rat model. Pain, 2013, Volume: 154, Issue:3 Topics: Animals; Anthracenes; Bone Neoplasms; Carbamates; Carcinoma; Down-Regulation; Female; Ganglia, Spinal; Hot Temperature; Hyperalgesia; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Mammary Neoplasms, Experimental; Neoplasm Transplantation; Nociception; Pain; Patch-Clamp Techniques; Phenylenediamines; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Stress, Mechanical; Synaptic Transmission; Tibia	2013
Triple cysteine module within M-type K+ channels mediates reciprocal channel modulation by nitric oxide and reactive oxygen species. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, Apr-03, Volume: 33, Issue:14 Topics: Action Potentials; Aniline Compounds; Animals; Animals, Newborn; Anthracenes; Benzoates; Biotin; Calcitonin Gene-Related Peptide; Carbamates; Cells, Cultured; Cysteine; Enzyme Inhibitors; Female; Humans; Imidazoles; KCNQ Potassium Channels; Male; Membrane Transport Modulators; Models, Molecular; Mutation; Neurons; Nitric Oxide; Nitric Oxide Donors; Patch-Clamp Techniques; Phenylenediamines; Potassium Channel Blockers; Rats; Reactive Oxygen Species; S-Nitroso-N-Acetylpenicillamine; Transfection; Trigeminal Ganglion	2013
M-channels modulate network excitatory activity induced by 4-aminopyridine in immature rat substantia gelatinosa in vitro. Brain research, 2013, Jun-04, Volume: 1513 Topics: 4-Aminopyridine; Action Potentials; Aminopyridines; Analgesics; Animals; Animals, Newborn; Anthracenes; Biological Clocks; Biophysical Phenomena; Carbamates; Dose-Response Relationship, Drug; Drug Interactions; Female; In Vitro Techniques; Indoles; Male; Membrane Transport Modulators; Nerve Net; Neurons; Phenylenediamines; Potassium Channel Blockers; Pyridines; Rats; Rats, Wistar; Substantia Gelatinosa	2013
Kv7/M-type potassium channels in rat skin keratinocytes. Pflugers Archiv : European journal of physiology, 2013, Volume: 465, Issue:9 Topics: Action Potentials; Adenosine Triphosphate; Animals; Anthracenes; Calcium; Carbamates; Cells, Cultured; Cymenes; KCNQ2 Potassium Channel; Keratinocytes; Monoterpenes; Phenylenediamines; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Skin; TRPV Cation Channels	2013
Discovery of a retigabine derivative that inhibits KCNQ2 potassium channels. Acta pharmacologica Sinica, 2013, Volume: 34, Issue:10 Topics: Animals; Anthracenes; Anticonvulsants; Carbamates; CHO Cells; Cricetinae; Cricetulus; Drug Design; Inhibitory Concentration 50; KCNQ2 Potassium Channel; Patch-Clamp Techniques; Phenylenediamines; Potassium Channel Blockers; Structure-Activity Relationship	2013
Molecular expression and pharmacological evidence for a functional role of kv7 channel subtypes in Guinea pig urinary bladder smooth muscle. PloS one, 2013, Volume: 8, Issue:9 Topics: Acetylcholine; Animals; Anthracenes; Benzodiazepines; Blotting, Western; Carbamates; Cells, Cultured; Electric Stimulation; Guinea Pigs; Immunoenzyme Techniques; KCNQ Potassium Channels; Male; Membrane Transport Modulators; Muscle Contraction; Muscle, Smooth; Patch-Clamp Techniques; Phenylenediamines; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Urinary Bladder	2013
Expression and motor functional roles of voltage-dependent type 7 K(+) channels in the human taenia coli. European journal of pharmacology, 2013, Dec-05, Volume: 721, Issue:1-3 Topics: Aged; Aged, 80 and over; Aminopyridines; Anthracenes; Carbamates; Colon; Gastrointestinal Motility; Gene Expression Regulation; Humans; In Vitro Techniques; KCNQ Potassium Channels; Middle Aged; Phenylenediamines; RNA, Messenger	2013
KCNQ (Kv7) potassium channel activators as bronchodilators: combination with a β2-adrenergic agonist enhances relaxation of rat airways. American journal of physiology. Lung cellular and molecular physiology, 2014, Mar-15, Volume: 306, Issue:6 Topics: Acetylcholine; Adrenergic beta-2 Receptor Agonists; Animals; Anthracenes; Asthma; Bronchi; Bronchoconstriction; Bronchoconstrictor Agents; Bronchodilator Agents; Carbamates; Ethanolamines; Formoterol Fumarate; KCNQ Potassium Channels; Keratolytic Agents; Male; Membrane Transport Modulators; Methacholine Chloride; Myocytes, Smooth Muscle; Organometallic Compounds; Patch-Clamp Techniques; Phenylenediamines; Potassium Channel Blockers; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Sulfonamides	2014
Activation of peripheral KCNQ channels attenuates inflammatory pain. Molecular pain, 2014, Feb-21, Volume: 10 Topics: Animals; Anthracenes; Anticonvulsants; Benzamides; Carbamates; Disease Models, Animal; Electric Stimulation; Exploratory Behavior; Formaldehyde; Freund's Adjuvant; Functional Laterality; Hyperalgesia; Inflammation; KCNQ Potassium Channels; Motor Skills Disorders; Pain; Pain Measurement; Pain Threshold; Phenylenediamines; Potassium Channel Blockers; Pyridines; Rats	2014
Diabetes attenuates urothelial modulation of detrusor contractility and spontaneous activity. International journal of urology : official journal of the Japanese Urological Association, 2014, Volume: 21, Issue:10 Topics: Animals; Anthracenes; Carbachol; Carbamates; Cholinergic Agonists; Diabetes Mellitus, Experimental; KCNQ Potassium Channels; Large-Conductance Calcium-Activated Potassium Channels; Male; Membrane Transport Modulators; Muscle Contraction; Peptides; Phenylenediamines; Rats; Rats, Inbred F344; Tetraethylammonium; Urinary Bladder; Urothelium	2014
KCNQ/Kv7 channel activator flupirtine protects against acute stress-induced impairments of spatial memory retrieval and hippocampal LTP in rats. Neuroscience, 2014, Nov-07, Volume: 280 Topics: Aminopyridines; Animals; Anthracenes; Carbamates; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Long-Term Potentiation; Male; Maze Learning; Memory Disorders; Nootropic Agents; Phenylenediamines; Phosphorylation; Potassium Channel Blockers; Rats, Sprague-Dawley; Spatial Memory; Stress, Psychological	2014
Suppression of KCNQ/M (Kv7) potassium channels in the spinal cord contributes to the sensitization of dorsal horn WDR neurons and pain hypersensitivity in a rat model of bone cancer pain. Oncology reports, 2015, Volume: 33, Issue:3 Topics: Acetylcholine; Animals; Anthracenes; Bone Neoplasms; Carbamates; Disease Models, Animal; Female; Hyperalgesia; KCNQ Potassium Channels; Membrane Transport Modulators; Neoplasm Transplantation; Pain; Phenylenediamines; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Spinal Cord	2015
Augmentation of M-type (KCNQ) potassium channels as a novel strategy to reduce stroke-induced brain injury. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015, Feb-04, Volume: 35, Issue:5 Topics: Animals; Anthracenes; Carbamates; Drug Therapy, Combination; Infarction, Middle Cerebral Artery; KCNQ Potassium Channels; Male; Mice; Mice, Inbred C57BL; Phenylenediamines; Potassium Channel Blockers	2015
Thalamic Kv 7 channels: pharmacological properties and activity control during noxious signal processing. British journal of pharmacology, 2015, Volume: 172, Issue:12 Topics: Action Potentials; Acute Pain; Animals; Anthracenes; Brain; Carbamates; Disease Models, Animal; KCNQ Potassium Channels; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Mice; Mice, Inbred C57BL; Neurons; Pain Threshold; Phenylenediamines; Thalamus	2015
Kv7 channels in the nucleus accumbens are altered by chronic drinking and are targets for reducing alcohol consumption. Addiction biology, 2016, Volume: 21, Issue:6 Topics: Alcohol Deterrents; Alcohol Drinking; Alcohol Withdrawal Seizures; Animals; Anthracenes; Anticonvulsants; Behavior, Animal; Carbamates; Conditioning, Operant; Genomics; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Male; Membrane Transport Modulators; Microinjections; Motor Activity; Nucleus Accumbens; Phenylenediamines; Potassium Channel Blockers; Rats, Wistar; Sumoylation; Taste Perception	2016
M-current preservation contributes to anticonvulsant effects of valproic acid. The Journal of clinical investigation, 2015, Oct-01, Volume: 125, Issue:10 Topics: A Kinase Anchor Proteins; Action Potentials; Animals; Anthracenes; Anticonvulsants; Carbamates; Cells, Cultured; Drug Interactions; Female; Hippocampus; Humans; Kainic Acid; KCNQ2 Potassium Channel; Lipoylation; Male; Mice; Mice, Inbred C57BL; Muscarinic Agonists; Muscarinic Antagonists; Neurons; Phenylenediamines; Phosphorylation; Potassium Channel Blockers; Protein Processing, Post-Translational; Rats; Receptor, Muscarinic M1; Recombinant Fusion Proteins; Seizures; Signal Transduction; Superior Cervical Ganglion; Valproic Acid	2015
Activation of neuronal Kv7/KCNQ/M-channels by the opener QO58-lysine and its anti-nociceptive effects on inflammatory pain in rodents. Acta pharmacologica Sinica, 2016, Volume: 37, Issue:8 Topics: Animals; Anthracenes; Biological Availability; Carbamates; Dose-Response Relationship, Drug; HEK293 Cells; Humans; KCNQ Potassium Channels; Lysine; Male; Membrane Potentials; Pain Measurement; Phenylenediamines; Rats	2016
Retigabine diminishes the effects of acetylcholine, adrenaline and adrenergic agonists on the spontaneous activity of guinea pig smooth muscle strips in vitro. Autonomic neuroscience : basic & clinical, 2017, Volume: 203 Topics: Acetylcholine; Adrenergic Agonists; Animals; Anthracenes; Carbamates; Cholinergic Agonists; Clonidine; Drug Interactions; Epinephrine; Guinea Pigs; Isoproterenol; KCNQ Potassium Channels; Membrane Potentials; Methoxamine; Muscle Contraction; Muscle, Smooth; Phenylenediamines; Random Allocation; Stomach; Tissue Culture Techniques	2017
XE991 and Linopirdine Are State-Dependent Inhibitors for Kv7/KCNQ Channels that Favor Activated Single Subunits. The Journal of pharmacology and experimental therapeutics, 2017, Volume: 362, Issue:1 Topics: Animals; Anthracenes; Carbamates; CHO Cells; Cricetinae; Cricetulus; Indoles; KCNQ1 Potassium Channel; KCNQ2 Potassium Channel; Kinetics; Membrane Potentials; Mutation; Patch-Clamp Techniques; Phenylenediamines; Potassium Channel Blockers; Protein Subunits; Pyridines; Rats	2017
Effect of M-current modulation on mammalian vestibular responses to transient head motion. Journal of neurophysiology, 2017, 12-01, Volume: 118, Issue:6 Topics: Animals; Anthracenes; Carbamates; Evoked Potentials; Female; Head Movements; KCNQ Potassium Channels; Membrane Transport Modulators; Mice; Mice, Inbred C57BL; Motor Neurons; Phenylenediamines; Vestibule, Labyrinth	2017
KCNQ/M-channels regulate mouse vagal bronchopulmonary C-fiber excitability and cough sensitivity. JCI insight, 2019, 03-07, Volume: 4, Issue:5 Topics: Action Potentials; Animals; Anthracenes; Carbamates; Cough; KCNQ Potassium Channels; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Lung; Male; Mice; Mice, Inbred C57BL; Models, Animal; Nerve Tissue Proteins; Nodose Ganglion; Patch-Clamp Techniques; Phenylenediamines; RNA, Messenger; Transcriptome; Vagus Nerve	2019
Nicotine enhances object recognition memory through inhibition of voltage-dependent potassium 7 channels in the medial prefrontal cortex of mice. Journal of pharmacological sciences, 2021, Volume: 147, Issue:1 Topics: Animals; Anthracenes; Carbamates; Male; Memory; Mice, Inbred C57BL; Nicotine; Phenylenediamines; Potassium Channels, Voltage-Gated; Prefrontal Cortex; Recognition, Psychology; Stimulation, Chemical	2021