Compounds > ezogabine
Page last updated: 2024-09-03

ezogabine and tryptophan

ezogabine has been researched along with tryptophan in 6 studies

Compound Research Comparison

Studies
(ezogabine)		Trials
(ezogabine)		Recent Studies (post-2010)
(ezogabine)		Studies
(tryptophan)		Trials
(tryptophan)		Recent Studies (post-2010) (tryptophan)
3832624132,7629367,183

Protein Interaction Comparison

ProteinTaxonomyezogabine (IC50)tryptophan (IC50)
MyeloperoxidaseHomo sapiens (human)2.25

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (66.67)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Friedrich, T; Grötzinger, J; Jentsch, TJ; Pusch, M; Saftig, P; Schenzer, A; Schwake, M1
Friedrich, T; Geissendörfer, J; Grötzinger, J; Lange, W; Schenzer, A; Schwake, M; Seebohm, G1
Gerlach, AC; McCormack, K; Padilla, K; Wickenden, AD1
Blom, SM; Jensen, HS; Schmitt, N1
Ahern, CA; Galpin, JD; Kim, RY; Kurata, HT; Pless, SA; Seebohm, G; Yau, MC1
Aizenman, E; Kumar, M; Liu, R; Reed, N; Tzounopoulos, T; Wipf, P1

Other Studies

6 other study(ies) available for ezogabine and tryptophan

ArticleYear
Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, May-18, Volume: 25, Issue:20

    Topics: Animals; Anticonvulsants; Carbamates; Cloning, Molecular; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Electric Stimulation; Humans; KCNQ Potassium Channels; Membrane Potentials; Microinjections; Models, Molecular; Mutagenesis; Oocytes; Patch-Clamp Techniques; Phenylenediamines; Point Mutation; Protein Structure, Tertiary; Sequence Alignment; Tryptophan; Xenopus

2005
Refinement of the binding site and mode of action of the anticonvulsant Retigabine on KCNQ K+ channels.
    Molecular pharmacology, 2009, Volume: 75, Issue:2

    Topics: Action Potentials; Animals; Anticonvulsants; Binding Sites; Carbamates; KCNQ3 Potassium Channel; Leucine; Membrane Potentials; Models, Molecular; Phenylenediamines; Tryptophan; Xenopus laevis

2009
The KCNQ2/3 selective channel opener ICA-27243 binds to a novel voltage-sensor domain site.
    Neuroscience letters, 2009, Nov-13, Volume: 465, Issue:2

    Topics: Amino Acid Sequence; Animals; Anticonvulsants; Benzamides; Binding Sites; Carbamates; CHO Cells; Cricetinae; Cricetulus; Humans; KCNQ Potassium Channels; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Membrane Potentials; Membrane Transport Modulators; Molecular Sequence Data; Mutation; Phenylenediamines; Pyridines; Sequence Alignment; Tryptophan

2009
The acrylamide (S)-2 as a positive and negative modulator of Kv7 channels expressed in Xenopus laevis oocytes.
    PloS one, 2009, Dec-11, Volume: 4, Issue:12

    Topics: Acrylamide; Acrylamides; Animals; Binding Sites; Carbamates; Humans; Ion Channel Gating; KCNQ Potassium Channels; Kinetics; Membrane Potentials; Mutant Proteins; Oocytes; Oxazines; Phenylenediamines; Tryptophan; Xenopus laevis

2009
Atomic basis for therapeutic activation of neuronal potassium channels.
    Nature communications, 2015, Sep-03, Volume: 6

    Topics: Animals; Anticonvulsants; Carbamates; Fluorine; Humans; Hydrogen Bonding; KCNQ Potassium Channels; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Molecular Docking Simulation; Mutagenesis, Site-Directed; Neurons; Oocytes; Patch-Clamp Techniques; Phenylenediamines; Tryptophan; Xenopus laevis

2015
Synthesis and Evaluation of Potent KCNQ2/3-Specific Channel Activators.
    Molecular pharmacology, 2016, Volume: 89, Issue:6

    Topics: Animals; Carbamates; CHO Cells; Conserved Sequence; Cricetinae; Cricetulus; Drug Synergism; Halogenation; Humans; Ion Channel Gating; KCNQ Potassium Channels; Membrane Transport Modulators; Phenylenediamines; Protein Subunits; Structure-Activity Relationship; Tryptophan

2016