Page last updated: 2024-09-03

ezogabine and linopirdine

ezogabine has been researched along with linopirdine in 29 studies

Compound Research Comparison

Studies (ezogabine)	Trials (ezogabine)	Recent Studies (post-2010) (ezogabine)	Studies (linopirdine)	Trials (linopirdine)	Recent Studies (post-2010) (linopirdine)
383	26	241	169	8	44

Research

Studies (29)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	19 (65.52)	29.6817
2010's	9 (31.03)	24.3611
2020's	1 (3.45)	2.80

Authors

Authors	Studies
Jegla, T; Wagoner, PK; Wickenden, AD; Yu, W; Zou, A	1
Jegla, T; Wagoner, PK; Wickenden, AD; Zou, A	1
Abogadie, FC; Brown, DA; Delmas, P; Tatulian, L	1
Christensen, JK; Christophersen, P; Dupuis, DS; Jensen, BS; Jespersen, T; Olesen, SP; Schrøder, RL	1
Crankshaw, DJ; Scott, CW; Trivedi, S; Wilkins, DE	1
Al-Qatari, M; Brown, DA; Brown, TA; Burbidge, SA; Dickenson, AH; Main, M; Marsh, SJ; Matthews, EA; Mistry, M; Passmore, GM; Selyanko, AA	1
Hoffmann, EK; Hougaard, C; Jorgensen, NK; Klaerke, DA; Olesen, SP	1
Dost, R; Rostock, A; Rundfeldt, C	1
Yaari, Y; Yue, C	1
Frankel, WN; Otto, JF; White, HS; Wilcox, KS; Yang, Y	1
Jan, LY; Surti, TS	1
Brown, JT; Piccinin, S; Randall, AD	1
Churchill, JF; Lawrence, JJ; McBain, CJ; Saraga, F; Skinner, FK; Statland, JM; Travis, KE	1
Hu, H; Storm, JF; Vervaeke, K	1
Calloe, K; Elmedyb, P; Grunnet, M; Hansen, RS; Olesen, SP; Schmitt, N	1
Greenwood, IA; Moffatt, JD; Ohya, S; Pucovský, V; Saldanha, L; Schwake, M; Yeung, SY	1
Johnson, BN; Qiu, C; Tallent, MK	1
Cherubini, E; Safiulina, VF; Taglialatela, M; Yaari, Y; Zacchi, P	1
Greenwood, IA; Jepps, TA; Moffatt, JD; Ohya, S; Sanders, KM	1
Baraban, SC; Chege, SW; Hortopan, GA; T Dinday, M	1
Cavaliere, S; Hodge, JJ	1
Hughes, BA; Pattnaik, BR	1
King, AE; Visockis, V	1
Hill, MA; Lee, S; Li, M; Tanner, MA; Yang, Y	1
Abidi, A; Aniksztejn, L; Becq, H; Devaux, J; Lacoste, C; Milh, M; Molinari, F; Roubertie, A; Villard, L	1
Byron, KL; Majetschak, M; Nassoiy, SP	1
Greene, DL; Hoshi, N; Kang, S	1
Ambrosino, P; Manocchio, L; Miceli, F; Mosca, I; Soldovieri, MV; Taglialatela, M	1
Li, T; Shen, H; Wang, Y; Wu, K; Yue, Z; Zhang, F	1

Reviews

2 review(s) available for ezogabine and linopirdine

Article	Year
A potassium channel, the M-channel, as a therapeutic target. Current opinion in investigational drugs (London, England : 2000), 2005, Volume: 6, Issue:7 Topics: Animals; Carbamates; Central Nervous System Agents; Clinical Trials as Topic; Humans; Indoles; Molecular Structure; Phenylenediamines; Potassium Channels, Voltage-Gated; Pyridines	2005
Pharmacological Targeting of Neuronal Kv7.2/3 Channels: A Focus on Chemotypes and Receptor Sites. Current medicinal chemistry, 2018, Volume: 25, Issue:23 Topics: Animals; Carbamates; Epilepsy; Humans; Indoles; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Membrane Transport Modulators; Neurons; Phenylenediamines; Potassium Channel Blockers; Pyridines	2018

Other Studies

27 other study(ies) available for ezogabine and linopirdine

Article	Year
Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels. Molecular pharmacology, 2000, Volume: 58, Issue:3 Topics: Animals; Anticonvulsants; Barium; Carbamates; Cell Differentiation; Cell Line; CHO Cells; Cricetinae; Drug Interactions; Electrophysiology; Humans; Indoles; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; PC12 Cells; Phenylenediamines; Potassium; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Rats; Transfection	2000
Characterization of KCNQ5/Q3 potassium channels expressed in mammalian cells. British journal of pharmacology, 2001, Volume: 132, Issue:2 Topics: Animals; Anticonvulsants; Barium; Carbamates; CHO Cells; Cricetinae; Electrophysiology; Indoles; KCNQ3 Potassium Channel; Oocytes; Patch-Clamp Techniques; Phenylenediamines; Plasmids; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Xenopus laevis	2001
Activation of expressed KCNQ potassium currents and native neuronal M-type potassium currents by the anti-convulsant drug retigabine. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Aug-01, Volume: 21, Issue:15 Topics: Action Potentials; Animals; Anticonvulsants; Carbamates; Cells, Cultured; CHO Cells; Cricetinae; Humans; Indoles; Ion Transport; KCNQ Potassium Channels; KCNQ1 Potassium Channel; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Muscarinic Agonists; Neurons; Patch-Clamp Techniques; Phenylenediamines; Potassium; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1; Receptors, Muscarinic; Superior Cervical Ganglion; Sympathetic Nervous System; Transfection	2001
Activation of KCNQ5 channels stably expressed in HEK293 cells by BMS-204352. European journal of pharmacology, 2002, Feb-22, Volume: 437, Issue:3 Topics: Anthracenes; Carbamates; Cell Line; Dose-Response Relationship, Drug; Gene Expression; Humans; Indoles; KCNQ Potassium Channels; Membrane Potentials; Phenylenediamines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines	2002
A medium-throughput functional assay of KCNQ2 potassium channels using rubidium efflux and atomic absorption spectrometry. Analytical biochemistry, 2003, Aug-15, Volume: 319, Issue:2 Topics: Anthracenes; Carbamates; Cell Line; Clone Cells; Dose-Response Relationship, Drug; Humans; Indoles; KCNQ2 Potassium Channel; Kinetics; Phenylenediamines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Potassium Chloride; Pyridines; Quaternary Ammonium Compounds; Rubidium; Spectrophotometry, Atomic; Tetraethylammonium; Transfection	2003
KCNQ/M currents in sensory neurons: significance for pain therapy. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Aug-06, Volume: 23, Issue:18 Topics: Animals; Anthracenes; Anura; Carbamates; Cells, Cultured; CHO Cells; Cricetinae; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Indoles; Male; Neurons, Afferent; Oocytes; Pain; Pain Management; Pain Measurement; Patch-Clamp Techniques; Phenylenediamines; Potassium Channel Blockers; Potassium Channels; Pyridines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Transfection	2003
Modulation of KCNQ4 channel activity by changes in cell volume. Biochimica et biophysica acta, 2004, Jan-28, Volume: 1660, Issue:1-2 Topics: Calcium; Carbamates; Cell Line; Cell Size; Cyclic AMP-Dependent Protein Kinases; Humans; Indoles; KCNQ Potassium Channels; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Osmolar Concentration; Patch-Clamp Techniques; Phenylenediamines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Kinase C; Pyridines; Signal Transduction	2004
The anti-hyperalgesic activity of retigabine is mediated by KCNQ potassium channel activation. Naunyn-Schmiedeberg's archives of pharmacology, 2004, Volume: 369, Issue:4 Topics: Acute Disease; Amines; Analgesics, Opioid; Animals; Carbamates; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Indoles; Ion Channel Gating; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Male; Mice; Peripheral Nervous System Diseases; Phenylenediamines; Physical Stimulation; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Pyridines; Rats; Rats, Wistar; Spinal Nerves; Touch; Tramadol	2004
KCNQ/M channels control spike afterdepolarization and burst generation in hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, May-12, Volume: 24, Issue:19 Topics: Action Potentials; Animals; Anthracenes; Carbamates; Hippocampus; In Vitro Techniques; Indoles; Neurons; Phenylenediamines; Potassium; Potassium Channel Blockers; Potassium Channels; Pyramidal Cells; Pyridines; Rats	2004
Mice carrying the szt1 mutation exhibit increased seizure susceptibility and altered sensitivity to compounds acting at the m-channel. Epilepsia, 2004, Volume: 45, Issue:9 Topics: Animals; Anticonvulsants; Carbamates; Disease Models, Animal; Electroshock; Female; Genetic Predisposition to Disease; Indoles; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Mutant Strains; Mutation; Nerve Tissue Proteins; Phenylenediamines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Receptors, Nicotinic; Seizures; Sequence Deletion	2004
KCNQ/Kv7 channel regulation of hippocampal gamma-frequency firing in the absence of synaptic transmission. Journal of neurophysiology, 2006, Volume: 95, Issue:5 Topics: Action Potentials; Animals; Anthracenes; Calcium; Carbamates; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Hippocampus; In Vitro Techniques; Indoles; KCNQ Potassium Channels; Male; Neurons; Periodicity; Phenylenediamines; Potassium; Potassium Channel Blockers; Pyridines; Rats; Synaptic Transmission	2006
Somatodendritic Kv7/KCNQ/M channels control interspike interval in hippocampal interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Nov-22, Volume: 26, Issue:47 Topics: Action Potentials; Animals; Anthracenes; Carbamates; Cell Line; Computer Simulation; Dendrites; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Green Fluorescent Proteins; Hippocampus; Humans; Immunohistochemistry; In Vitro Techniques; Indoles; Interneurons; KCNQ Potassium Channels; Membrane Potentials; Mice; Mice, Transgenic; Models, Neurological; Patch-Clamp Techniques; Phenylenediamines; Potassium Channel Blockers; Pyridines; Tetraethylammonium; Transfection	2006
M-channels (Kv7/KCNQ channels) that regulate synaptic integration, excitability, and spike pattern of CA1 pyramidal cells are located in the perisomatic region. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, Feb-21, Volume: 27, Issue:8 Topics: Action Potentials; Animals; Anthracenes; Calcium; Carbamates; Cerebral Cortex; Computer Simulation; Dendrites; Electrophysiology; Excitatory Postsynaptic Potentials; Extracellular Space; In Vitro Techniques; Indoles; KCNQ Potassium Channels; Male; Models, Neurological; Patch-Clamp Techniques; Phenylenediamines; Potassium Channel Blockers; Pyramidal Cells; Pyridines; Rats; Rats, Wistar; Synapses; Tissue Distribution	2007
Modulation of ERG channels by XE991. Basic & clinical pharmacology & toxicology, 2007, Volume: 100, Issue:5 Topics: Acetylcholine; Animals; Anthracenes; Carbamates; Cell Line; Chromans; Dose-Response Relationship, Drug; Electrophysiology; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Gene Expression; Indoles; Oocytes; Patch-Clamp Techniques; Phenylenediamines; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Pyridines; Xenopus laevis	2007
Molecular expression and pharmacological identification of a role for K(v)7 channels in murine vascular reactivity. British journal of pharmacology, 2007, Volume: 151, Issue:6 Topics: Aminopyridines; Animals; Anthracenes; Carbamates; Dose-Response Relationship, Drug; Gene Expression Profiling; Immunohistochemistry; Indoles; Isometric Contraction; KCNQ Potassium Channels; KCNQ1 Potassium Channel; Meclofenamic Acid; Mice; Mice, Inbred BALB C; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phenylenediamines; Potassium Channel Blockers; Potassium Channels; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA	2007
K+ M-current regulates the transition to seizures in immature and adult hippocampus. Epilepsia, 2007, Volume: 48, Issue:11 Topics: Action Potentials; Animals; Anticonvulsants; Carbamates; Disease Models, Animal; Epilepsy, Benign Neonatal; Hippocampus; Humans; Indoles; Male; Mutation; Phenylenediamines; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures	2007
Low expression of Kv7/M channels facilitates intrinsic and network bursting in the developing rat hippocampus. The Journal of physiology, 2008, Nov-15, Volume: 586, Issue:22 Topics: Action Potentials; Animals; Animals, Newborn; Carbamates; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Indoles; KCNQ2 Potassium Channel; Kinetics; Nerve Net; Phenylenediamines; Potassium Channel Blockers; Pyramidal Cells; Pyridines; Rats; Rats, Wistar; Sodium Potassium Chloride Symporter Inhibitors; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; Synaptic Transmission	2008
Molecular and functional characterization of Kv7 K+ channel in murine gastrointestinal smooth muscles. American journal of physiology. Gastrointestinal and liver physiology, 2009, Volume: 297, Issue:1 Topics: Animals; Anthracenes; Blotting, Western; Carbamates; Chromans; Colon; Gastrointestinal Tract; Immunohistochemistry; Indoles; KCNQ Potassium Channels; KCNQ1 Potassium Channel; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Myography; Phenylenediamines; Potassium Channel Blockers; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides	2009
Expression and function of KCNQ channels in larval zebrafish. Developmental neurobiology, 2012, Volume: 72, Issue:2 Topics: Action Potentials; Analysis of Variance; Animals; Anthracenes; Anticonvulsants; Brain; Carbamates; Dose-Response Relationship, Drug; Electrophysiology; Gene Expression Regulation, Developmental; Indoles; KCNQ Potassium Channels; Larva; Locomotion; Morpholinos; Phenylenediamines; Potassium Channel Blockers; Pyridines; RNA, Messenger; Swimming; Zebrafish	2012
Drosophila KCNQ channel displays evolutionarily conserved electrophysiology and pharmacology with mammalian KCNQ channels. PloS one, 2011, Volume: 6, Issue:9 Topics: Animals; Anthracenes; Carbamates; Cell Line; Chromans; Drosophila; Drosophila Proteins; Electrophysiology; Humans; Indoles; KCNQ Potassium Channels; KCNQ1 Potassium Channel; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Organometallic Compounds; Patch-Clamp Techniques; Phenylenediamines; Pyridines; Sulfonamides	2011
Effects of KCNQ channel modulators on the M-type potassium current in primate retinal pigment epithelium. American journal of physiology. Cell physiology, 2012, Mar-01, Volume: 302, Issue:5 Topics: Animals; Carbamates; Cells, Cultured; Chromans; Ethylmaleimide; Indoles; KCNQ Potassium Channels; Macaca fascicularis; Macaca mulatta; Neurons; Organometallic Compounds; Patch-Clamp Techniques; Phenylenediamines; Potassium; Potassium Channel Blockers; Protein Subunits; Pyridines; Retinal Pigment Epithelium; Sulfonamides; Tetraethylammonium	2012
M-channels modulate network excitatory activity induced by 4-aminopyridine in immature rat substantia gelatinosa in vitro. Brain research, 2013, Jun-04, Volume: 1513 Topics: 4-Aminopyridine; Action Potentials; Aminopyridines; Analgesics; Animals; Animals, Newborn; Anthracenes; Biological Clocks; Biophysical Phenomena; Carbamates; Dose-Response Relationship, Drug; Drug Interactions; Female; In Vitro Techniques; Indoles; Male; Membrane Transport Modulators; Nerve Net; Neurons; Phenylenediamines; Potassium Channel Blockers; Pyridines; Rats; Rats, Wistar; Substantia Gelatinosa	2013
Heterogeneity in Kv7 channel function in the cerebral and coronary circulation. Microcirculation (New York, N.Y. : 1994), 2015, Volume: 22, Issue:2 Topics: Animals; Basilar Artery; Carbamates; Cerebrovascular Circulation; Circle of Willis; Colforsin; Coronary Circulation; Indoles; KCNQ Potassium Channels; KCNQ1 Potassium Channel; Male; Mice; Mice, Knockout; Muscle Contraction; Muscle, Smooth, Vascular; Organ Specificity; Phenylenediamines; Potassium Channel Blockers; Pyridines; Vasoconstriction; Vasodilation; Vasodilator Agents	2015
A Kv7.2 mutation associated with early onset epileptic encephalopathy with suppression-burst enhances Kv7/M channel activity. Epilepsia, 2016, Volume: 57, Issue:5 Topics: Animals; Ankyrins; Anticonvulsants; Carbamates; CHO Cells; Cricetulus; Electric Stimulation; Female; Hippocampus; Humans; Indoles; KCNQ2 Potassium Channel; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Phenylenediamines; Polymorphism, Single Nucleotide; Potassium Channel Blockers; Pyridines; Spasms, Infantile	2016
Kv7 voltage-activated potassium channel inhibitors reduce fluid resuscitation requirements after hemorrhagic shock in rats. Journal of biomedical science, 2017, Jan-17, Volume: 24, Issue:1 Topics: Animals; Carbamates; Indoles; KCNQ Potassium Channels; Male; Phenylenediamines; Potassium Channel Blockers; Pyridines; Rats; Rats, Sprague-Dawley; Resuscitation; Shock, Hemorrhagic	2017
XE991 and Linopirdine Are State-Dependent Inhibitors for Kv7/KCNQ Channels that Favor Activated Single Subunits. The Journal of pharmacology and experimental therapeutics, 2017, Volume: 362, Issue:1 Topics: Animals; Anthracenes; Carbamates; CHO Cells; Cricetinae; Cricetulus; Indoles; KCNQ1 Potassium Channel; KCNQ2 Potassium Channel; Kinetics; Membrane Potentials; Mutation; Patch-Clamp Techniques; Phenylenediamines; Potassium Channel Blockers; Protein Subunits; Pyridines; Rats	2017
Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs. Molecular cell, 2021, 01-07, Volume: 81, Issue:1 Topics: Animals; Carbamates; Cryoelectron Microscopy; Humans; Indoles; KCNQ Potassium Channels; Mutation; Phenylenediamines; Phosphatidylinositol 4,5-Diphosphate; Protein Domains; Pyridines; Sf9 Cells; Spodoptera	2021