ezogabine has been researched along with lamotrigine in 11 studies
| Studies (ezogabine) | Trials (ezogabine) | Recent Studies (post-2010) (ezogabine) | Studies (lamotrigine) | Trials (lamotrigine) | Recent Studies (post-2010) (lamotrigine) |
|---|---|---|---|---|---|
| 383 | 26 | 241 | 3,550 | 501 | 1,351 |
| Protein | Taxonomy | ezogabine (IC50) | lamotrigine (IC50) |
|---|---|---|---|
| Sodium channel protein type 2 subunit alpha | Homo sapiens (human) | 10 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (45.45) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 2 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Rekling, JC | 1 |
| Borlak, J; Hermann, R; Knebel, NG; Locher, M; Niebch, G; Richards, L | 1 |
| Dencker, D; Dias, R; Husum, H; Pedersen, ML | 1 |
| Czuczwar, SJ; Luszczki, JJ; Raszewski, G; Wu, JZ | 1 |
| Nielsen, AN; Redrobe, JP | 1 |
| Pietrzak, B; Zwierzyńska, E | 1 |
| Vossler, DG; Yilmaz, U | 1 |
| Brandt, C; Daniluk, J; DeRossett, S; Edwards, S; Lerche, H; Lotay, N | 1 |
| Bastin, ML; Cook, AM; Oyler, DR; Smetana, KS | 1 |
| Hotta, N; Miyamoto, M; Suzuki, K | 1 |
| Bleakley, LE; McKenzie, CE; Reid, CA | 1 |
2 review(s) available for ezogabine and lamotrigine
| Article | Year |
|---|---|
[Retigabine - a new antiepileptic drug with a different mechanism of action].
Topics: Adult; Anticonvulsants; Carbamates; Drug Interactions; GABA Modulators; Humans; Lamotrigine; Membrane Transport Modulators; Phenylenediamines; Potassium Channels; Seizures; Triazines | 2013 |
Antiepileptic dosing for critically ill adult patients receiving renal replacement therapy.
Topics: Acetamides; Acute Kidney Injury; Amines; Anticonvulsants; Carbamates; Critical Illness; Cyclohexanecarboxylic Acids; Dibenzazepines; Dose-Response Relationship, Drug; Ethosuximide; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lacosamide; Lamotrigine; Levetiracetam; Phenobarbital; Phenylcarbamates; Phenylenediamines; Phenytoin; Piracetam; Propylene Glycols; Renal Dialysis; Renal Replacement Therapy; Seizures; Topiramate; Triazines; Valproic Acid; Zonisamide | 2016 |
2 trial(s) available for ezogabine and lamotrigine
| Article | Year |
|---|---|
Pharmacokinetic interaction between retigabine and lamotrigine in healthy subjects.
Topics: Adult; Anticonvulsants; Area Under Curve; Carbamates; Drug Interactions; Half-Life; Humans; Lamotrigine; Male; Metabolic Clearance Rate; Phenylenediamines; Triazines | 2003 |
Efficacy and safety of ezogabine/retigabine as adjunctive therapy to specified single antiepileptic medications in an open-label study of adults with partial-onset seizures.
Topics: Aged; Anticonvulsants; Carbamates; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilepsies, Partial; Female; Humans; Kaplan-Meier Estimate; Lamotrigine; Levetiracetam; Male; Middle Aged; Oxcarbazepine; Phenylenediamines; Piracetam; Seizures; Treatment Outcome; Triazines; Valproic Acid | 2015 |
7 other study(ies) available for ezogabine and lamotrigine
| Article | Year |
|---|---|
Neuroprotective effects of anticonvulsants in rat hippocampal slice cultures exposed to oxygen/glucose deprivation.
Topics: Acetates; Amines; Animals; Anticonvulsants; Carbamates; Carbamazepine; Cell Death; Cells, Cultured; Chlordiazepoxide; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Ethosuximide; Felbamate; Gabapentin; gamma-Aminobutyric Acid; Glucose; Hippocampus; Hypoxia; Ischemia; Lamotrigine; Levetiracetam; Midazolam; Neurons; Neuroprotective Agents; Nipecotic Acids; Oxcarbazepine; Phenobarbital; Phenylcarbamates; Phenylenediamines; Phenytoin; Piracetam; Propylene Glycols; Rats; Rats, Wistar; Tiagabine; Triazines; Valproic Acid | 2003 |
Effect of the new antiepileptic drug retigabine in a rodent model of mania.
Topics: Amphetamine; Animals; Anticonvulsants; Behavior, Animal; Bipolar Disorder; Carbamates; Chlordiazepoxide; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Lamotrigine; Lithium Chloride; Male; Motor Activity; Phenylenediamines; Rats; Rats, Wistar; Triazines | 2008 |
Isobolographic characterization of interactions of retigabine with carbamazepine, lamotrigine, and valproate in the mouse maximal electroshock-induced seizure model.
Topics: Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Brain; Carbamates; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Electroshock; Injections, Intraperitoneal; Lamotrigine; Male; Memory; Mice; Motor Activity; Muscle Strength; Phenylenediamines; Psychomotor Performance; Seizures; Triazines; Valproic Acid | 2009 |
Effects of neuronal Kv7 potassium channel activators on hyperactivity in a rodent model of mania.
Topics: Amphetamine; Animals; Anticonvulsants; Antimanic Agents; Benzamides; Bipolar Disorder; Carbamates; Central Nervous System Stimulants; Chlordiazepoxide; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Hyperkinesis; Indoles; Injections, Intraperitoneal; KCNQ Potassium Channels; Lamotrigine; Lithium Compounds; Male; Mice; Mice, Inbred C57BL; Motor Activity; Phenylenediamines; Pyridines; Triazines | 2009 |
Ezogabine treatment of childhood absence epilepsy.
Topics: Anticonvulsants; Carbamates; Drug Interactions; Electroencephalography; Epilepsy, Absence; Female; Humans; Isoxazoles; Lamotrigine; Middle Aged; Phenylenediamines; Treatment Outcome; Triazines; Zonisamide | 2014 |
Lamotrigine and retigabine increase motor threshold in transcranial magnetic stimulation at the dose required to produce an antiepileptic effect against maximal electroshock-induced seizure in rats.
Topics: Animals; Anticonvulsants; Carbamates; Electroshock; Evoked Potentials, Motor; Lamotrigine; Male; Phenylenediamines; Rats; Rats, Sprague-Dawley; Seizures; Transcranial Magnetic Stimulation | 2022 |
Efficacy of antiseizure medication in a mouse model of HCN1 developmental and epileptic encephalopathy.
Topics: Animals; Anticonvulsants; Epilepsy; Epilepsy, Generalized; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Lamotrigine; Mice; Potassium Channels; Seizures; Valproic Acid | 2023 |