Compounds > ezogabine

Page last updated: 2024-09-03

ezogabine and ica 27243

ezogabine has been researched along with ica 27243 in 9 studies

Compound Research Comparison

Studies (ezogabine)	Trials (ezogabine)	Recent Studies (post-2010) (ezogabine)	Studies (ica 27243)	Trials (ica 27243)	Recent Studies (post-2010) (ica 27243)
383	26	241	17	0	8

Research

Studies (9)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (33.33)	29.6817
2010's	6 (66.67)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Dalby-Brown, W; Munro, G	1
Bakshi, T; Bhamidipati, R; Brady, P; Cato, M; Chapman, M; Chaudhary, KW; Donovan, B; Dougherty, RW; Downie, D; Fu, T; Higgins, GA; Holenz, J; Kuppusamy, BM; Lin, H; Lluel, P; Madhyastha, N; Matsuoka, Y; Mohd, Z; Morrow, D; Pasikanti, K; Rajagopal, S; Rouget, C; Samanta, SK; Seefeld, MA; Zhen, W	1
Nielsen, AN; Redrobe, JP	1
Gerlach, AC; McCormack, K; Padilla, K; Wickenden, AD	1
Blom, SM; Jensen, HS; Schmitt, N	1
Hansen, HH; Kristensen, LV; Sandager-Nielsen, K	2
Hansen, HH; Jensen, MM; Lange, SC; Mikkelsen, JD; Thomsen, MS	1
Hayashi, H; Iwata, M; Matsumoto, T; Tsuchimori, N	1

Reviews

1 review(s) available for ezogabine and ica 27243

Article	Year
Kv7 (KCNQ) channel modulators and neuropathic pain. Journal of medicinal chemistry, 2007, May-31, Volume: 50, Issue:11 Topics: Analgesics; Animals; Humans; Ion Channel Gating; KCNQ Potassium Channels; Pain; Peripheral Nervous System Diseases; Signal Transduction	2007

Other Studies

8 other study(ies) available for ezogabine and ica 27243

Article	Year
Novel K Bioorganic & medicinal chemistry letters, 2018, 12-15, Volume: 28, Issue:23-24 Topics: Animals; Anticonvulsants; Epilepsy; Humans; KCNQ Potassium Channels; Mice; Muscle Contraction; Muscle, Smooth; Protein Isoforms; Seizures; Urinary Bladder	2018
Effects of neuronal Kv7 potassium channel activators on hyperactivity in a rodent model of mania. Behavioural brain research, 2009, Mar-17, Volume: 198, Issue:2 Topics: Amphetamine; Animals; Anticonvulsants; Antimanic Agents; Benzamides; Bipolar Disorder; Carbamates; Central Nervous System Stimulants; Chlordiazepoxide; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Hyperkinesis; Indoles; Injections, Intraperitoneal; KCNQ Potassium Channels; Lamotrigine; Lithium Compounds; Male; Mice; Mice, Inbred C57BL; Motor Activity; Phenylenediamines; Pyridines; Triazines	2009
The KCNQ2/3 selective channel opener ICA-27243 binds to a novel voltage-sensor domain site. Neuroscience letters, 2009, Nov-13, Volume: 465, Issue:2 Topics: Amino Acid Sequence; Animals; Anticonvulsants; Benzamides; Binding Sites; Carbamates; CHO Cells; Cricetinae; Cricetulus; Humans; KCNQ Potassium Channels; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Membrane Potentials; Membrane Transport Modulators; Molecular Sequence Data; Mutation; Phenylenediamines; Pyridines; Sequence Alignment; Tryptophan	2009
Differential effects of ICA-27243 on cloned K(V)7 channels. Pharmacology, 2010, Volume: 86, Issue:3 Topics: Animals; Benzamides; Binding Sites; Carbamates; Cells, Cultured; CHO Cells; Cloning, Molecular; Cricetinae; Cricetulus; Female; KCNQ Potassium Channels; KCNQ2 Potassium Channel; Membrane Potentials; Oocytes; Phenylenediamines; Pyridines; Rubidium Radioisotopes; Xenopus laevis	2010
Kv7 (KCNQ) channel openers induce hypothermia in the mouse. Neuroscience letters, 2011, Jan-20, Volume: 488, Issue:2 Topics: Animals; Anthracenes; Anticonvulsants; Benzamides; Body Temperature Regulation; Carbamates; Female; Hypothermia; Indoles; KCNQ Potassium Channels; Mice; Phenylenediamines; Protein Isoforms; Pyridines	2011
The pharmacological effect of positive KCNQ (Kv7) modulators on dopamine release from striatal slices. Basic & clinical pharmacology & toxicology, 2011, Volume: 109, Issue:5 Topics: Animals; Anthracenes; Anticonvulsants; Benzamides; Carbamates; Dopamine; Dopamine Antagonists; In Vitro Techniques; Indoles; Inhibitory Concentration 50; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Male; Mesencephalon; Neostriatum; Neurons; Nonlinear Dynamics; Phenylenediamines; Potassium Channel Blockers; Potassium Chloride; Pyridines; Rats; Rats, Wistar; Regression Analysis	2011
K(v) 7 (KCNQ) channel openers normalize central 2-deoxyglucose uptake in a mouse model of mania and increase prefrontal cortical and hippocampal serine-9 phosphorylation levels of GSK3β. Journal of neurochemistry, 2012, Volume: 121, Issue:3 Topics: Animals; Antimanic Agents; Autoradiography; Benzamides; Bipolar Disorder; Carbamates; Central Nervous System Stimulants; Chlordiazepoxide; Deoxyglucose; Dextroamphetamine; Dose-Response Relationship, Drug; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; Hypnotics and Sedatives; KCNQ Potassium Channels; Male; Mice; Mice, Inbred C57BL; Phenylenediamines; Phosphorylation; Prefrontal Cortex; Pyridines; Serine	2012
Activation of peripheral KCNQ channels attenuates inflammatory pain. Molecular pain, 2014, Feb-21, Volume: 10 Topics: Animals; Anthracenes; Anticonvulsants; Benzamides; Carbamates; Disease Models, Animal; Electric Stimulation; Exploratory Behavior; Formaldehyde; Freund's Adjuvant; Functional Laterality; Hyperalgesia; Inflammation; KCNQ Potassium Channels; Motor Skills Disorders; Pain; Pain Measurement; Pain Threshold; Phenylenediamines; Potassium Channel Blockers; Pyridines; Rats	2014