ezogabine has been researched along with gamma-aminobutyric acid in 14 studies
*gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system. [MeSH]
*gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system. [MeSH]
| Studies (ezogabine) | Trials (ezogabine) | Recent Studies (post-2010) (ezogabine) | Studies (gamma-aminobutyric acid) | Trials (gamma-aminobutyric acid) | Recent Studies (post-2010) (gamma-aminobutyric acid) |
|---|---|---|---|---|---|
| 383 | 26 | 241 | 40,215 | 1,423 | 9,631 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 11 (78.57) | 29.6817 |
| 2010's | 2 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kapetanovic, IM; Kupferberg, HJ; Yonekawa, WD | 1 |
| Dost, R; Rundfeldt, C | 1 |
| Brodie, MJ; Butler, E; Forrest, G; Rundfeldt, C; Sills, GJ; Thompson, GG | 1 |
| Netzer, R; Rundfeldt, C | 1 |
| Rekling, JC | 1 |
| van Rijn, CM; Willems-van Bree, E | 2 |
| Annunziato, L; Castaldo, P; D'Amico, M; Martire, M; Preziosi, P; Taglialatela, M | 1 |
| Dost, R; Rostock, A; Rundfeldt, C | 1 |
| Green, AC; Harrison, PK; Sheridan, RD; Tattersall, JE | 1 |
| Miura, Y | 1 |
| Cherubini, E; Safiulina, VF; Taglialatela, M; Yaari, Y; Zacchi, P | 1 |
| Kaba, H; Takahashi, Y | 1 |
| Bastin, ML; Cook, AM; Oyler, DR; Smetana, KS | 1 |
2 review(s) available for ezogabine and gamma-aminobutyric acid
| Article | Year |
|---|---|
[A new aspect in the research on antiepileptic drugs].
Topics: Acetamides; Amines; Animals; Anticonvulsants; Benzodiazepines; Carbamates; Cyclohexanecarboxylic Acids; Disease Models, Animal; Drug Design; Gabapentin; gamma-Aminobutyric Acid; Humans; Lacosamide; Levetiracetam; Phenylenediamines; Piracetam; Pregabalin; Pregnanolone; Pyrrolidinones; Triazoles | 2007 |
Antiepileptic dosing for critically ill adult patients receiving renal replacement therapy.
Topics: Acetamides; Acute Kidney Injury; Amines; Anticonvulsants; Carbamates; Critical Illness; Cyclohexanecarboxylic Acids; Dibenzazepines; Dose-Response Relationship, Drug; Ethosuximide; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lacosamide; Lamotrigine; Levetiracetam; Phenobarbital; Phenylcarbamates; Phenylenediamines; Phenytoin; Piracetam; Propylene Glycols; Renal Dialysis; Renal Replacement Therapy; Seizures; Topiramate; Triazines; Valproic Acid; Zonisamide | 2016 |
12 other study(ies) available for ezogabine and gamma-aminobutyric acid
| Article | Year |
|---|---|
The effects of D-23129, a new experimental anticonvulsant drug, on neurotransmitter amino acids in the rat hippocampus in vitro.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Carbamates; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; Nerve Tissue Proteins; Neurotransmitter Agents; Phenylenediamines; Rats; Rats, Inbred Strains; Tetrodotoxin | 1995 |
The anticonvulsant retigabine potently suppresses epileptiform discharges in the low Ca ++ and low Mg++ model in the hippocampal slice preparation.
Topics: Animals; Anticonvulsants; Calcium; Carbamates; Electrophysiology; Epilepsy; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Magnesium Deficiency; Male; Phenylenediamines; Potassium Channels; Rats; Rats, Wistar | 2000 |
A neurochemical study of the novel antiepileptic drug retigabine in mouse brain.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Brain Chemistry; Carbamates; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Glutamine; Male; Mice; Mice, Inbred ICR; Phenylenediamines | 2000 |
Investigations into the mechanism of action of the new anticonvulsant retigabine. Interaction with GABAergic and glutamatergic neurotransmission and with voltage gated ion channels.
Topics: Animals; Anticonvulsants; Calcium Channels; Carbamates; Cells, Cultured; Excitatory Amino Acid Agonists; Female; gamma-Aminobutyric Acid; Glutamic Acid; Ion Channel Gating; Kainic Acid; Neurons; Patch-Clamp Techniques; Phenylenediamines; Rats; Sodium Channels; Synaptic Transmission | 2000 |
Neuroprotective effects of anticonvulsants in rat hippocampal slice cultures exposed to oxygen/glucose deprivation.
Topics: Acetates; Amines; Animals; Anticonvulsants; Carbamates; Carbamazepine; Cell Death; Cells, Cultured; Chlordiazepoxide; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Ethosuximide; Felbamate; Gabapentin; gamma-Aminobutyric Acid; Glucose; Hippocampus; Hypoxia; Ischemia; Lamotrigine; Levetiracetam; Midazolam; Neurons; Neuroprotective Agents; Nipecotic Acids; Oxcarbazepine; Phenobarbital; Phenylcarbamates; Phenylenediamines; Phenytoin; Piracetam; Propylene Glycols; Rats; Rats, Wistar; Tiagabine; Triazines; Valproic Acid | 2003 |
Synergy between retigabine and GABA in modulating the convulsant site of the GABAA receptor complex.
Topics: Animals; Anticonvulsants; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Carbamates; Dose-Response Relationship, Drug; Drug Synergism; gamma-Aminobutyric Acid; Kinetics; Models, Biological; Phenylenediamines; Rats; Rats, Wistar; Receptors, GABA-A; Tritium | 2003 |
M channels containing KCNQ2 subunits modulate norepinephrine, aspartate, and GABA release from hippocampal nerve terminals.
Topics: Aminopyridines; Animals; Anthracenes; Anticonvulsants; Aspartic Acid; Carbamates; CHO Cells; Cricetinae; gamma-Aminobutyric Acid; Hippocampus; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Male; Norepinephrine; Patch-Clamp Techniques; Phenylenediamines; Potassium; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Presynaptic Terminals; Protein Subunits; Rats; Synaptosomes | 2004 |
A four-ligand hypercube model to quantify allosteric interactions within the GABAA receptor complex.
Topics: Allosteric Site; Animals; Binding Sites; Carbamates; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Ligands; Models, Chemical; Models, Molecular; Models, Neurological; Phenylenediamines; Prosencephalon; Rats; Rats, Wistar; Receptors, GABA-A | 2004 |
The anti-hyperalgesic activity of retigabine is mediated by KCNQ potassium channel activation.
Topics: Acute Disease; Amines; Analgesics, Opioid; Animals; Carbamates; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Indoles; Ion Channel Gating; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Male; Mice; Peripheral Nervous System Diseases; Phenylenediamines; Physical Stimulation; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Pyridines; Rats; Rats, Wistar; Spinal Nerves; Touch; Tramadol | 2004 |
Effects of anticonvulsants on soman-induced epileptiform activity in the guinea-pig in vitro hippocampus.
Topics: Amines; Animals; Anticonvulsants; Carbamates; Carbamazepine; Chlormethiazole; Clozapine; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Levetiracetam; Male; Phenylcarbamates; Phenylenediamines; Piracetam; Propylene Glycols; Soman; Topiramate | 2005 |
Low expression of Kv7/M channels facilitates intrinsic and network bursting in the developing rat hippocampus.
Topics: Action Potentials; Animals; Animals, Newborn; Carbamates; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Indoles; KCNQ2 Potassium Channel; Kinetics; Nerve Net; Phenylenediamines; Potassium Channel Blockers; Pyramidal Cells; Pyridines; Rats; Rats, Wistar; Sodium Potassium Chloride Symporter Inhibitors; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; Synaptic Transmission | 2008 |
Muscarinic receptor type 1 (M1) stimulation, probably through KCNQ/Kv7 channel closure, increases spontaneous GABA release at the dendrodendritic synapse in the mouse accessory olfactory bulb.
Topics: Alkaloids; Animals; Anticonvulsants; Calcium; Calcium Channel Blockers; Calcium Channels, R-Type; Carbachol; Carbamates; Cholinergic Agonists; Dendrites; Diclofenac; Excitatory Amino Acid Antagonists; Furans; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Ion Channel Gating; KCNQ Potassium Channels; Mice; Mice, Inbred BALB C; Muscarinic Antagonists; Naphthalenes; Nimodipine; Olfactory Bulb; Patch-Clamp Techniques; Phenylenediamines; Piperidines; Pirenzepine; Potassium Channel Blockers; Receptor, Muscarinic M1; Receptors, Glutamate; Synapses | 2010 |