Page last updated: 2024-09-03

ezogabine and flupirtine

ezogabine has been researched along with flupirtine in 25 studies

Compound Research Comparison

Studies (ezogabine)	Trials (ezogabine)	Recent Studies (post-2010) (ezogabine)	Studies (flupirtine)	Trials (flupirtine)	Recent Studies (post-2010) (flupirtine)
383	26	241	292	48	117

Protein Interaction Comparison

Protein	Taxonomy	ezogabine (IC50)	flupirtine (IC50)
Serine hydroxymethyltransferase, mitochondrial	Homo sapiens (human)		0.9333

Research

Studies (25)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	8 (32.00)	29.6817
2010's	12 (48.00)	24.3611
2020's	5 (20.00)	2.80

Authors

Authors	Studies
Al-Ahmad, A; Boustany, RM; Kinarivala, N; Patel, R; Trippier, PC	1
Freiberg, GM; Osuma, AT; Van Camp, JA; Wang, Z; Xu, X	1
Hernandez, CC; Hill, C; Keith Duncan, R; Liu, R; Miguel I Limcaoco, J; Mondal, P; O'Meara, MJ; Stephenson, CRJ; Tarfa, RA; Tzounopoulos, T; Wipf, P	1
Evert, BO; Klockgether, T; Kovar, KA; Rundfeldt, C; Schulz, JB; Seyfried, J; Wüllner, U	1
Lawson, K	1
Annunziato, L; Castaldo, P; D'Amico, M; Martire, M; Preziosi, P; Taglialatela, M	1
Dworetzky, SI; Wua, YJ	1
Annunziato, L; Boscia, F; Taglialatela, M	1
Greenwood, IA; Moffatt, JD; Ohya, S; Pucovský, V; Saldanha, L; Schwake, M; Yeung, SY	1
Martire, M; Miceli, F; Soldovieri, MV; Taglialatela, M	1
Greenwood, Ia; Pucovský, V; Schwake, M; Yeung, S	1
England, SK; Greenwood, IA; McCallum, LA; Pierce, SL; Tribe, RM	1
Brueggemann, LI; Byron, KL; Cribbs, LL; Dowell, ML; Kakad, PP; Love, RB; Solway, J	1
Hamann, M; Lange, N; Lemm, C; Richter, A; Sander, SE	1
Gamper, N; Huang, D; Linley, JE; Pettinger, L	1
King, AE; Visockis, V	1
Adduci, A; Arena, V; Coco, C; Currò, D; Martire, M; Rizzo, G; Taglialatela, M	1
Guo, L; Huang, P; Li, C; Lu, Q; Xu, X; Zhou, M	1
Ambrosino, P; Barrese, V; Breschi, MC; Calderone, V; Canduela, MJ; Curtis, MJ; Grandes, P; Greenwood, IA; Martelli, A; Miceli, F; Scorziello, A; Sisalli, MJ; Soldovieri, MV; Taglialatela, M; Testai, L; Vinciguerra, I	1
Lopez-Garcia, JA; Rivera-Arconada, I; Vicente-Baz, J	1
Burris, KD; Eastwood, BJ; Priest, BT; Sher, E; Wilenkin, B; Williams, AC	1
Huo, B; Jin, L; Li, H; Liu, R; Liu, S; Tang, L; Wang, Y; Yang, T; Zhang, F; Zhao, X	1
Bartz, FM; Bednarski, PJ; Bodtke, A; Link, A; Schulig, L; Wurm, KW	1
Barreira, B; Cho, S; Climent, B; Cogolludo, A; de Olaiz, B; Greenwood, I; Kim, SJ; Kwon, JW; Morales-Cano, D; Moreno, L; Navarro-Dorado, J; Pérez-Vizcaíno, F; Telli, G; Vera-Zambrano, A; Villegas-Esguevillas, M	1
Chen, YM; Huang, CN; Jiang, X; Li, Z; Qin, HM; Xiao, XY; Zhang, GS; Zhou, HL; Zhu, J; Zhuang, T	1

Reviews

3 review(s) available for ezogabine and flupirtine

Article	Year
Is there a role for potassium channel openers in neuronal ion channel disorders? Expert opinion on investigational drugs, 2000, Volume: 9, Issue:10 Topics: Aminopyridines; Animals; Anticonvulsants; Antihypertensive Agents; Ataxia; Carbamates; Diazoxide; Epilepsy; Humans; Ion Channels; Isaacs Syndrome; Membrane Potentials; Mice; Mice, Neurologic Mutants; Mutation; Nervous System Diseases; Neuroprotective Agents; Parkinson Disease; Phenylenediamines; Potassium Channels	2000
Recent developments on KCNQ potassium channel openers. Current medicinal chemistry, 2005, Volume: 12, Issue:4 Topics: Acrylamides; Aminopyridines; Benzamides; Carbamates; Epilepsy; Humans; Indoles; Ion Channel Gating; KCNQ Potassium Channels; KCNQ1 Potassium Channel; Migraine Disorders; Oxindoles; Pain; Phenylenediamines; Potassium Channels, Voltage-Gated	2005
Molecular pharmacology and therapeutic potential of neuronal Kv7-modulating drugs. Current opinion in pharmacology, 2008, Volume: 8, Issue:1 Topics: Aminopyridines; Animals; Binding Sites; Carbamates; Epilepsy, Benign Neonatal; Hearing Loss; Humans; KCNQ Potassium Channels; KCNQ1 Potassium Channel; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Phenylenediamines	2008

Other Studies

22 other study(ies) available for ezogabine and flupirtine

Article	Year
Discovery of Aromatic Carbamates that Confer Neuroprotective Activity by Enhancing Autophagy and Inducing the Anti-Apoptotic Protein B-Cell Lymphoma 2 (Bcl-2). Journal of medicinal chemistry, 2017, 12-14, Volume: 60, Issue:23 Topics: Animals; Autophagy; Carbamates; Cell Line; Drug Discovery; Humans; Neurons; Neuroprotection; Neuroprotective Agents; Proto-Oncogene Proteins c-bcl-2; Rats	2017
Design and evaluation of pyrazolopyrimidines as KCNQ channel modulators. Bioorganic & medicinal chemistry letters, 2019, 10-01, Volume: 29, Issue:19 Topics: Drug Design; Humans; Hyperalgesia; Ion Channel Gating; KCNQ Potassium Channels; Potassium Channel Blockers; Pyrazoles; Pyrimidines	2019
Development of an automated screen for Kv7.2 potassium channels and discovery of a new agonist chemotype. Bioorganic & medicinal chemistry letters, 2022, 09-01, Volume: 71 Topics: KCNQ Potassium Channels; KCNQ2 Potassium Channel	2022
Flupirtine and retigabine prevent L-glutamate toxicity in rat pheochromocytoma PC 12 cells. European journal of pharmacology, 2000, Jul-21, Volume: 400, Issue:2-3 Topics: Aminopyridines; Analgesics; Animals; Antidepressive Agents; Carbamates; Cell Death; Clorgyline; Culture Media; Cystine; Dopamine Agents; Excitatory Amino Acid Antagonists; Glutamic Acid; Glutathione; Levodopa; Monoamine Oxidase; Monoamine Oxidase Inhibitors; PC12 Cells; Phenylenediamines; Rats; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate	2000
M channels containing KCNQ2 subunits modulate norepinephrine, aspartate, and GABA release from hippocampal nerve terminals. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Jan-21, Volume: 24, Issue:3 Topics: Aminopyridines; Animals; Anthracenes; Anticonvulsants; Aspartic Acid; Carbamates; CHO Cells; Cricetinae; gamma-Aminobutyric Acid; Hippocampus; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Male; Norepinephrine; Patch-Clamp Techniques; Phenylenediamines; Potassium; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Presynaptic Terminals; Protein Subunits; Rats; Synaptosomes	2004
Retigabine and flupirtine exert neuroprotective actions in organotypic hippocampal cultures. Neuropharmacology, 2006, Volume: 51, Issue:2 Topics: Aminopyridines; Animals; Carbamates; Culture Media, Serum-Free; Glucose; Hippocampus; KCNQ Potassium Channels; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Oxygen; Phenylenediamines; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; Tissue Culture Techniques	2006
Molecular expression and pharmacological identification of a role for K(v)7 channels in murine vascular reactivity. British journal of pharmacology, 2007, Volume: 151, Issue:6 Topics: Aminopyridines; Animals; Anthracenes; Carbamates; Dose-Response Relationship, Drug; Gene Expression Profiling; Immunohistochemistry; Indoles; Isometric Contraction; KCNQ Potassium Channels; KCNQ1 Potassium Channel; Meclofenamic Acid; Mice; Mice, Inbred BALB C; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phenylenediamines; Potassium Channel Blockers; Potassium Channels; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA	2007
Bimodal effects of the Kv7 channel activator retigabine on vascular K+ currents. British journal of pharmacology, 2008, Volume: 155, Issue:1 Topics: Aminopyridines; Animals; Anthracenes; Carbamates; Dose-Response Relationship, Drug; In Vitro Techniques; KCNQ Potassium Channels; KCNQ1 Potassium Channel; Membrane Potentials; Mice; Mice, Inbred BALB C; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phenylenediamines; Portal Vein; Potassium; Potassium Channel Blockers; Recombinant Proteins; RNA, Messenger; Time Factors; Vasoconstriction; Vasodilator Agents; Xenopus laevis	2008
The contribution of Kv7 channels to pregnant mouse and human myometrial contractility. Journal of cellular and molecular medicine, 2011, Volume: 15, Issue:3 Topics: Aminopyridines; Animals; Anthracenes; Anticonvulsants; Carbamates; Female; Gene Expression; Gestational Age; Humans; KCNQ Potassium Channels; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Myometrium; Phenylenediamines; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Pregnancy; Protein Isoforms; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Uterine Contraction	2011
Kv7 potassium channels in airway smooth muscle cells: signal transduction intermediates and pharmacological targets for bronchodilator therapy. American journal of physiology. Lung cellular and molecular physiology, 2012, Jan-01, Volume: 302, Issue:1 Topics: Aminopyridines; Animals; Anthracenes; Bronchoconstriction; Bronchodilator Agents; Calcium Channel Blockers; Carbamates; Celecoxib; Guinea Pigs; Histamine; Humans; KCNQ Potassium Channels; Male; Methacholine Chloride; Myocytes, Smooth Muscle; Patch-Clamp Techniques; Phenylenediamines; Pyrazoles; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sulfonamides; Verapamil	2012
Retigabine, a K(V)7 (KCNQ) potassium channel opener, attenuates L-DOPA-induced dyskinesias in 6-OHDA-lesioned rats. Neuropharmacology, 2012, Volume: 62, Issue:2 Topics: Amantadine; Aminopyridines; Animals; Anticonvulsants; Antiparkinson Agents; Behavior, Animal; Carbamates; Dyskinesia, Drug-Induced; Female; Motor Activity; Oxidopamine; Phenylenediamines; Rats; Rats, Sprague-Dawley; Stereotyped Behavior	2012
M channel enhancers and physiological M channel block. The Journal of physiology, 2012, Feb-15, Volume: 590, Issue:4 Topics: Aminopyridines; Animals; Bradykinin; Calcium; Carbamates; CHO Cells; Cricetinae; Cricetulus; Ganglia, Spinal; Hydrogen Peroxide; Inflammation; KCNQ Potassium Channels; Organometallic Compounds; Pain; Phenylenediamines; Phosphatidylinositol 4,5-Diphosphate; Pyridines; Rats; Rats, Wistar; Sensory Receptor Cells; Type C Phospholipases	2012
M-channels modulate network excitatory activity induced by 4-aminopyridine in immature rat substantia gelatinosa in vitro. Brain research, 2013, Jun-04, Volume: 1513 Topics: 4-Aminopyridine; Action Potentials; Aminopyridines; Analgesics; Animals; Animals, Newborn; Anthracenes; Biological Clocks; Biophysical Phenomena; Carbamates; Dose-Response Relationship, Drug; Drug Interactions; Female; In Vitro Techniques; Indoles; Male; Membrane Transport Modulators; Nerve Net; Neurons; Phenylenediamines; Potassium Channel Blockers; Pyridines; Rats; Rats, Wistar; Substantia Gelatinosa	2013
Expression and motor functional roles of voltage-dependent type 7 K(+) channels in the human taenia coli. European journal of pharmacology, 2013, Dec-05, Volume: 721, Issue:1-3 Topics: Aged; Aged, 80 and over; Aminopyridines; Anthracenes; Carbamates; Colon; Gastrointestinal Motility; Gene Expression Regulation; Humans; In Vitro Techniques; KCNQ Potassium Channels; Middle Aged; Phenylenediamines; RNA, Messenger	2013
KCNQ/Kv7 channel activator flupirtine protects against acute stress-induced impairments of spatial memory retrieval and hippocampal LTP in rats. Neuroscience, 2014, Nov-07, Volume: 280 Topics: Aminopyridines; Animals; Anthracenes; Carbamates; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Long-Term Potentiation; Male; Maze Learning; Memory Disorders; Nootropic Agents; Phenylenediamines; Phosphorylation; Potassium Channel Blockers; Rats, Sprague-Dawley; Spatial Memory; Stress, Psychological	2014
Expression and function of Kv7.4 channels in rat cardiac mitochondria: possible targets for cardioprotection. Cardiovascular research, 2016, May-01, Volume: 110, Issue:1 Topics: Aminopyridines; Animals; Carbamates; KCNQ Potassium Channels; Male; Membrane Potentials; Mitochondria, Heart; Myocytes, Cardiac; Phenylenediamines; Potassium Channel Blockers; Rats	2016
Targeting Kv7 channels in pain pathways. Oncotarget, 2017, Feb-21, Volume: 8, Issue:8 Topics: Aminopyridines; Animals; Carbamates; Deafness; Epilepsy; Humans; Inflammation; KCNQ Potassium Channels; Long QT Syndrome; Mutation; Neurons; Pain; Pain Management; Phenylenediamines; Protein Conformation	2017
Development of an Electrophysiological Assay for Kv7 Modulators on IonWorks Barracuda. Assay and drug development technologies, 2019, Volume: 17, Issue:7 Topics: Aminopyridines; Carbamates; Cells, Cultured; Drug Development; Electrophysiological Phenomena; HEK293 Cells; High-Throughput Screening Assays; Humans; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Patch-Clamp Techniques; Phenylenediamines	2019
Antinociceptive Efficacy of Retigabine and Flupirtine for Gout Arthritis Pain. Pharmacology, 2020, Volume: 105, Issue:7-8 Topics: Aminopyridines; Analgesics; Animals; Arthritis, Experimental; Arthritis, Gouty; Behavior, Animal; Carbamates; Disease Models, Animal; Hyperalgesia; KCNQ Potassium Channels; Male; Pain; Phenylenediamines; Rats; Rats, Sprague-Dawley; Uric Acid	2020
Carba Analogues of Flupirtine and Retigabine with Improved Oxidation Resistance and Reduced Risk of Quinoid Metabolite Formation. ChemMedChem, 2022, 08-17, Volume: 17, Issue:16 Topics: Aminopyridines; Carbamates; KCNQ Potassium Channels; Phenylenediamines	2022
The novel K Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 164 Topics: Animals; Humans; KCNQ Potassium Channels; Morpholinos; Potassium Channels, Voltage-Gated; Rats; Vasodilator Agents	2023
Pregabalin can interact synergistically with Kv7 channel openers to exert antinociception in mice. European journal of pharmacology, 2023, Sep-05, Volume: 954 Topics: Analgesics; Animals; Chronic Pain; Mice; Pregabalin	2023