ezogabine has been researched along with carbamates in 334 studies
| Studies (ezogabine) | Trials (ezogabine) | Recent Studies (post-2010) (ezogabine) | Studies (carbamates) | Trials (carbamates) | Recent Studies (post-2010) (carbamates) |
|---|---|---|---|---|---|
| 383 | 26 | 241 | 13,717 | 985 | 4,744 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (3.59) | 18.2507 |
| 2000's | 99 (29.64) | 29.6817 |
| 2010's | 195 (58.38) | 24.3611 |
| 2020's | 28 (8.38) | 2.80 |
| Authors | Studies |
|---|---|
| Adams-Curtis, LE; Cheong, JH; Dailey, JW; Jobe, PC; Ko, KH | 1 |
| Bartsch, R; Engel, J; Hönack, D; Kutscher, B; Löscher, W; Polymeropoulos, EE; Rostock, A; Rundfeldt, C; Tober, C; White, HS; Wolf, HH | 1 |
| Bartsch, R; Rostock, A; Rundfeldt, C; Tober, C | 1 |
| Bialer, M; Johannessen, SI; Kupferberg, HJ; Levy, RH; Loiseau, P; Perucca, E | 1 |
| Kapetanovic, IM; Kupferberg, HJ; Yonekawa, WD | 1 |
| Anderson, LW; Kapetanovic, IM; Kupferberg, HJ; McNeilly, PJ; Strong, JM; Torchin, CD | 1 |
| Rundfeldt, C | 2 |
| Armand, V; Heinemann, U; Rundfeldt, C | 2 |
| Engel, J; Hiller, A; Jainta, H; Kronbach, T; Li, Q; Nguyen, N; Pechstein, B; Ruus, P; Strassburg, CP; Tukey, RH | 1 |
| Engel, J; Griesinger, C; Grunwald, C; Heinecke, K; Hempel, R; Kronbach, C; Kronbach, T; McNeilly, PJ; Schupke, H; Zimmermann, G | 1 |
| Dost, R; Rundfeldt, C | 1 |
| Heinemann, U; Hetka, R; Rundfeldt, C; Schmitz, D | 1 |
| Netzer, R; Rundfeldt, C | 2 |
| Burbidge, SA; Clare, JJ; Cox, B; Cryan, JE; Dupere, JR; Main, MJ | 1 |
| Jegla, T; Wagoner, PK; Wickenden, AD; Yu, W; Zou, A | 1 |
| Evert, BO; Klockgether, T; Kovar, KA; Rundfeldt, C; Schulz, JB; Seyfried, J; Wüllner, U | 1 |
| Brodie, MJ; Butler, E; Forrest, G; Rundfeldt, C; Sills, GJ; Thompson, GG | 1 |
| Lawson, K | 1 |
| Grieb, S; Knebel, NG; Leisenheimer, S; Locher, M | 1 |
| Jegla, T; Wagoner, PK; Wickenden, AD; Zou, A | 1 |
| Conte, G; De Sarro, A; De Sarro, G; Di Paola, ED; Pasculli, MP | 1 |
| Ebner, A; Höhling, J; Köhling, R; Pannek, H; Rundfeldt, C; Speckmann, E; Straub, H; Tuxhorn, I; Wolf, P | 1 |
| Christophersen, P; Jensen, BS; Jespersen, T; Olesen, SP; Schrøder, RL; Strøbaek, D | 1 |
| Abogadie, FC; Brown, DA; Delmas, P; Tatulian, L | 1 |
| Ferron, GM; Fruncillo, R; Getsy, J; Knebel, N; Paul, J; Richards, L; Troy, S | 1 |
| Cooper, EC | 1 |
| Christensen, JK; Christophersen, P; Dupuis, DS; Jensen, BS; Jespersen, T; Olesen, SP; Schrøder, RL | 1 |
| Kimball, MM; Otto, JF; Wilcox, KS | 1 |
| Brandt, C; Ebert, U; Löscher, W | 1 |
| Rekling, JC | 1 |
| Cnota, HP; Erb, K; Ferron, GM; Hermann, R; Knebel, N; Paul, J; Richards, L; Ruus, P; Troy, S | 1 |
| Blackburn-Munro, G; Jensen, BS | 1 |
| van Rijn, CM; Willems-van Bree, E | 2 |
| Borlak, J; Hermann, R; Knebel, NG; Locher, M; Niebch, G; Richards, L | 1 |
| Brown, DA; Tatulian, L | 1 |
| Ferron, GM; Parks, V; Patat, A; Rolan, P; Troy, SM | 1 |
| Crankshaw, DJ; Scott, CW; Trivedi, S; Wilkins, DE | 1 |
| Al-Qatari, M; Brown, DA; Brown, TA; Burbidge, SA; Dickenson, AH; Main, M; Marsh, SJ; Matthews, EA; Mistry, M; Passmore, GM; Selyanko, AA | 1 |
| Boehm, S; Lechner, SG; Mayer, M | 1 |
| Annunziato, L; Castaldo, P; D'Amico, M; Martire, M; Preziosi, P; Taglialatela, M | 1 |
| Hoffmann, EK; Hougaard, C; Jorgensen, NK; Klaerke, DA; Olesen, SP | 1 |
| Lopez-Garcia, JA; Martinez-Gomez, J; Rivera-Arconada, I | 1 |
| Dost, R; Rostock, A; Rundfeldt, C | 1 |
| Yaari, Y; Yue, C | 1 |
| Mikkelsen, JD | 1 |
| Friederich, P; Punke, MA | 1 |
| Frankel, WN; Otto, JF; White, HS; Wilcox, KS; Yang, Y | 1 |
| Andersson, KE; Christoph, T; Streng, T | 1 |
| Attali, B; Degani, N; Gibor, G; Nachman, R; Peretz, A; Shabat, D; Uziyel, Y | 1 |
| Bail, S; Lerche, H; Maljevic, S; Seebohm, G; Wuttke, TV | 1 |
| Dworetzky, SI; Wua, YJ | 1 |
| Ahring, PK; Brown, WD; Hartz, BP; Korsgaard, MP; Mirza, NR; Strøbaek, D | 1 |
| Blackburn-Munro, G; Blackburn-Munro, RE; Dalby-Brown, W; Mikkelsen, JD; Mirza, NR | 1 |
| Friedrich, T; Grötzinger, J; Jentsch, TJ; Pusch, M; Saftig, P; Schenzer, A; Schwake, M | 1 |
| Boehm, S; Edelbauer, H; Lechner, SG; Mayer, M; Scholze, T | 1 |
| Jan, LY; Surti, TS | 1 |
| Green, AC; Harrison, PK; Sheridan, RD; Tattersall, JE | 1 |
| Mora, G; Tapia, R | 1 |
| Lopez-Garcia, JA; Rivera-Arconada, I | 2 |
| Brown, JT; Piccinin, S; Randall, AD | 1 |
| Annunziato, L; Boscia, F; Taglialatela, M | 1 |
| Borlak, J; Gasparic, A; Hermann, R; Locher, M; Schupke, H | 1 |
| Ebbesen, C; Hansen, HH; Mathiesen, C; Mikkelsen, JD; Rønn, LC; Scuvée-Moreau, J; Seutin, V; Waroux, O; Weikop, P | 1 |
| Plosker, GL; Scott, LJ | 1 |
| Agdestein, C; Gu, N; Hu, H; Storm, JF; Vervaeke, K | 1 |
| Amann, B; Grunze, H; Stampfer, R; Sterr, A; Vieta, E; Walden, J | 1 |
| Richter, A; Rundfeldt, C; Sander, SE | 1 |
| Churchill, JF; Lawrence, JJ; McBain, CJ; Saraga, F; Skinner, FK; Statland, JM; Travis, KE | 1 |
| Fujiyoshi, M; Hayashi, E; Hirano, K; Kinoshita, M; Kuratani, K; Tashiro, N | 1 |
| Nohria, V; Porter, RJ; Rundfeldt, C | 1 |
| Su, H; Yaari, Y; Yue, C | 1 |
| Miura, Y | 1 |
| Hu, H; Storm, JF; Vervaeke, K | 1 |
| Borges, V; Bu, W; Lin, CC; Nguyen, M; Xu, C; Yeh, LT | 1 |
| Adams, AC; Saunders, GW; Smith, MD; White, HS; Wilcox, KS | 1 |
| Alves, WM; Nohria, V; Partiot, A; Porter, RJ; Sachdeo, R | 1 |
| Annunziato, L; Barrese, V; D'Amico, M; Iannotti, FA; Lavergata, F; Martire, M; Miceli, F; Panza, E; Preziosi, P; Taglialatela, M; Viggiano, D | 1 |
| Calloe, K; Elmedyb, P; Grunnet, M; Hansen, RS; Olesen, SP; Schmitt, N | 1 |
| Greenwood, IA; Moffatt, JD; Ohya, S; Pucovský, V; Saldanha, L; Schwake, M; Yeung, SY | 1 |
| Andreasen, JT; Hansen, HH; Mikkelsen, JD; Mirza, N; Scheel-Krüger, J; Weikop, P | 1 |
| Johnson, BN; Qiu, C; Tallent, MK | 1 |
| Feng, B; Glazebrook, PA; Kunze, DL; Schild, JH; Wladyka, CL | 1 |
| Martire, M; Miceli, F; Soldovieri, MV; Taglialatela, M | 1 |
| Dencker, D; Dias, R; Husum, H; Pedersen, ML | 1 |
| Lerche, H; Maljevic, S; Wuttke, TV | 1 |
| Li, M; Nan, F; Sun, H; Xiong, Q; Zhang, Y | 1 |
| Lopez-Garcia, JA; Roza, C | 1 |
| Brown, DA; Fleckenstein, J; Grafe, P; Lang, PM; Passmore, GM | 1 |
| Kwon, YS; Mazarati, A; Sankar, R; Shin, D; Wu, J | 1 |
| Greenwood, Ia; Pucovský, V; Schwake, M; Yeung, S | 1 |
| Andersson, M; Baines, DL; Greenwood, IA; Hettiarachi, S; Yeung, SY | 1 |
| Greenwood, IA; McCallum, LA; Tribe, RM | 1 |
| Czuczwar, SJ; Luszczki, JJ; Raszewski, G; Wu, JZ | 1 |
| Cherubini, E; Safiulina, VF; Taglialatela, M; Yaari, Y; Zacchi, P | 1 |
| Holmqvist, M; Maduke, M | 1 |
| Friedrich, T; Geissendörfer, J; Grötzinger, J; Lange, W; Schenzer, A; Schwake, M; Seebohm, G | 1 |
| Bundgaard, C; Damgaard, T; Husum, H; Montezinho, LP; Mørk, A; Olsen, CK; Sotty, F | 1 |
| Nielsen, AN; Redrobe, JP | 1 |
| Brown, JT; Randall, AD | 1 |
| Boehm, S; Drobny, H; Kosenburger, K; Kubista, H; Mahlknecht, P | 1 |
| Greenwood, IA; Jepps, TA; Moffatt, JD; Ohya, S; Sanders, KM | 1 |
| Fisher, TE; Kosala, WR; Liu, XH; Rajapaksha, JS; Wang, D; Zhang, W | 1 |
| Boehlen, A; Heinemann, U; Kunert, A | 1 |
| Gerlach, AC; McCormack, K; Padilla, K; Wickenden, AD | 1 |
| Dencker, D; Husum, H | 1 |
| Blom, SM; Jensen, HS; Schmitt, N | 2 |
| Barrese, V; Iannotti, FA; Panza, E; Soldovieri, MV; Taglialatela, M; Viggiano, D | 1 |
| England, SK; Greenwood, IA; McCallum, LA; Pierce, SL; Tribe, RM | 1 |
| Kaba, H; Takahashi, Y | 1 |
| Rode, F; Rønn, LC; Sheykhzade, M; Svalø, J | 1 |
| Lerche, H; Maljevic, S; Seebohm, G; Wuttke, TV | 1 |
| Crean, CS; Dubrovska, G; Gloe, T; Gollasch, M; Huang, Y; Köhn, C; Luft, FC; Schleifenbaum, J; Schubert, R; Voblova, N; Zavarirskaya, O | 1 |
| Auvin, S; Kwon, YS; Mazarati, A; Pineda, E; Sankar, R; Shin, D | 1 |
| Bi, Y; Gan, Y; Tan, L; Wang, K; Wu, Y; Xu, W | 1 |
| Brodie, MJ; Elger, C; Gil-Nagel, A; Hall, S; Lerche, H; Mansbach, H; Nohria, V; Shin, P | 1 |
| Hansen, HH; Kristensen, LV; Sandager-Nielsen, K | 2 |
| Owen, RT | 1 |
| Abou-Khalil, BW; French, JA; Hall, S; Leroy, RF; Mansbach, H; Nohria, V; Shin, P; Yacubian, EM | 1 |
| Shapiro, MS; Zaika, O; Zhang, J | 1 |
| An, HL; Du, XN; Fu, Y; Gao, HX; Gao, ZB; Li, JW; Qi, JL; Wan, YM; Zhan, Y; Zhang, HL; Zhang, X | 1 |
| Hansen, HH; Jensen, MM; Lange, SC; Mikkelsen, JD; Thomsen, MS | 1 |
| Baraban, SC; Chege, SW; Hortopan, GA; T Dinday, M | 1 |
| Anderson, DJ; Baranowski, JL; DeGoey, DA; Gopalakrishnan, M; Honore, P; Patel, JR; Peddi, S; Perez-Medrano, A; Scanio, M; Surowy, CS; Thimmapaya, R; Wang, Z; Yao, BB; Zhang, D; Zhang, XF | 1 |
| Barrese, V; Currò, D; Ipavec, V; Martire, M; Taglialatela, M | 1 |
| Chadha, PS; Cockerill, GW; Davis, AJ; Greenwood, IA; Hansen, RS; Harhun, MI; Jepps, TA; Olesen, SP | 1 |
| Hansen, HH; Munro, G; Rode, F; Rønn, LC; Sheykhzade, M; Svalø, J | 1 |
| Cavaliere, S; Hodge, JJ | 1 |
| Deeks, ED | 1 |
| Nodera, H; Rutkove, S; Spieker, A; Sung, M | 1 |
| Ebers, O; Feuer, A; Halaszovich, CR; Leitner, MG; Oliver, D; Schreiber, DN | 1 |
| Grippon, S; Kirkpatrick, P; Stafstrom, CE | 1 |
| Brueggemann, LI; Byron, KL; Cribbs, LL; Dowell, ML; Kakad, PP; Love, RB; Solway, J | 1 |
| Bi, Y; Bian, X; Cao, X; Chen, H; Su, J; Wang, K | 1 |
| Szupera, Z | 1 |
| Hamann, M; Lange, N; Lemm, C; Richter, A; Sander, SE | 1 |
| Kaji, R | 1 |
| Hughes, BA; Pattnaik, BR | 1 |
| Gamper, N; Huang, D; Linley, JE; Pettinger, L | 1 |
| Belavic, JM | 1 |
| Gunthorpe, MJ; Large, CH; Sankar, R | 1 |
| Crean, CS; Gunthorpe, MJ; Large, CH; Nehlig, A; Sankar, R; Sokal, DM; Vanlandingham, KE; White, HS | 1 |
| Chabwine, JN; Démonet, JF; du Pasquier, RA; Hirt, L; Kuntzer, T; Michel, P; Rossetti, AR; Schluep, M; Vingerhoets, FG | 1 |
| Berry, DJ; Patsalos, PN | 1 |
| Brickel, N; DeRossett, S; Gandhi, P; Hammond, J; VanLandingham, K | 1 |
| Forcelli, PA; Gale, K; Kondratyev, A; Lakhkar, A; Soper, C | 1 |
| Burdette, DE; DeRossett, SE; Gil-Nagel, A; Hall, ST; Porter, RJ; Shaikh, S; White, R | 1 |
| Rheims, S; Ryvlin, P | 1 |
| Hecht, B | 1 |
| Mula, M | 1 |
| Brodie, MJ; Castiglia, M; Cyr, T; Gil-Nagel, A; Hall, S; Leroy, R; Twomey, C; VanLandingham, K | 1 |
| Lerche, H; Nies, AT; Orhan, G; Schwab, M; Wuttke, TV | 1 |
| Greenwood, IA; Jepps, TA; Olesen, SP | 1 |
| Hopkins, CR | 1 |
| Cooper, J; Duffy, S; Glanville, J; Hugel, P; Lane, PW; Martyn-St James, M; McCool, R | 1 |
| Splinter, MY | 1 |
| Kumar, M; Kumar, R; Verma, A | 1 |
| Huang, C; Liu, W; Wang, X; Yu, L; Zeng, S; Zheng, J; Zhou, H | 1 |
| Welty, TE; Yamada, M | 1 |
| Jarvis, MF; McGaraughty, S; Neelands, TR; Surowy, CS; Yao, B; Zhang, D; Zhang, XF | 1 |
| Brueggemann, LI; Byron, KL; Kumar, L; Mani, BK; O'Dowd, J; Ross, M | 1 |
| Hawryluk, JM; Moreira, TS; Mulkey, DK; Takakura, AC; Tzingounis, AV; Wenker, IC | 1 |
| Boehlen, A; Dost, R; Fidzinski, P; Gebhardt, C; Heinemann, U; Kunert, A; Schwake, M | 1 |
| Barrese, V; Formisano, L; Iannotti, FA; Miceli, F; Taglialatela, M | 1 |
| Kim, KS; Kobayashi, M; Takamatsu, K; Tzingounis, AV | 1 |
| Hussar, DA | 1 |
| Crean, CS; Tompson, DJ | 3 |
| Craig, D; Fox, D; Paton, F; Rice, S; Woolacott, N | 1 |
| Cai, J; Fang, D; Han, JS; Liu, M; Wan, Y; Xing, GG; Zheng, Q | 1 |
| Forsgren, L; Kristian, B; Stefan, F; Wachtmeister, K | 1 |
| Amabile, CM; Vasudevan, A | 1 |
| Ambrosino, P; Barrese, V; Cilio, MR; Miceli, F; Migliore, M; Soldovieri, MV; Taglialatela, M | 1 |
| Gamper, N; Gigout, S; Ooi, L; Pettinger, L | 1 |
| Buettner, C; Burstein, R; Gold, M; Jakubowski, M; Kainz, V; Zhang, X | 1 |
| King, AE; Visockis, V | 1 |
| Fretwell, LV; Woolard, J | 1 |
| Brown, DA; Marsh, SJ; Passmore, GM; Reilly, JM; Telezhkin, V | 1 |
| Gao, Z; Gu, M; Li, M; Nan, FJ; Yu, H; Zhou, P | 1 |
| Haut, SR; Lipton, RB | 1 |
| Burke, RA; Faulkner, MA | 1 |
| Berry, NS; Crean, CS; Reeve, R; Tompson, DJ | 1 |
| Legido, A; Valencia, I; Walleigh, DJ | 1 |
| Chen, F; Gao, ZB; Hu, HN; Li, M; Nan, FJ; Zhou, PZ | 1 |
| Abogadie, FC; Brown, DA; Passmore, GM; Reilly, JM; Robbins, J | 1 |
| Buraglio, M; Crean, CS; Tompson, DJ | 1 |
| Ilickovic, I; Jankovic, S | 1 |
| Afeli, SA; Malysz, J; Petkov, GV | 1 |
| Pietrzak, B; Zwierzyńska, E | 1 |
| Biton, V; Brodie, MJ; Derossett, SE; Gil-Nagel, A; Nohria, V | 1 |
| Adduci, A; Arena, V; Coco, C; Currò, D; Martire, M; Rizzo, G; Taglialatela, M | 1 |
| Bock, M; Danker, T; De Jonghe, P; Guenther, E; Ilina, EI; Jezutkovic, N; Lerche, H; Löffler, H; Maljevic, S; Mandelstam, S; Orhan, G; Reichel, SN; Scheffer, IE; Schepers, D; Suls, A; Weckhuysen, S | 1 |
| Mateos-Aparicio, P; Murphy, R; Storm, JF | 1 |
| Brueggemann, LI; Byron, KL; Cribbs, LL; Haick, JM; Neuburg, S; Randhawa, D; Tate, S | 1 |
| Cerný, J; Douša, M; Gibala, P; Havlíček, J; Klecán, O; Nováková, L; Pekárek, T; Rádl, S; Srbek, J; Tkadlecová, M | 1 |
| Hayashi, H; Iwata, M; Matsumoto, T; Tsuchimori, N | 1 |
| Diezi, L; Livio, F; Renard, D; Rothuizen, LE | 1 |
| Hatch, RJ; Petrou, S; Reid, CA | 1 |
| Vossler, DG; Yilmaz, U | 1 |
| Adams, B; Brodie, MJ; DeRossett, S; French, JA; Lee, WJ; McDonald, SA; Nohria, V; Scott, A | 1 |
| Ciraulo, DA; Datta, S; Knapp, CM; O'Malley, M | 1 |
| Biton, V; DeRossett, S; Nohria, V; Partiot, A; Porter, RJ; Rosenfeld, WE; Sachdeo, R; Tompson, D | 1 |
| Davies, KP; Fu, S; Melman, A; Tar, MT; Wang, Y | 1 |
| Bergman, R; Didkovsky, E; Feuerman, H; Garin Shkolnik, T; Hodak, E; Kaplan, I; Pavlovsky, L | 1 |
| Ali, SS; Friedman, LK; Naseer, Z; Slomko, AM; Wongvravit, JP | 1 |
| Song, X; Su, J; Zhang, D | 1 |
| Du, X; Gamper, N; Gigout, S; Hao, H; Huang, D; Jaffe, DB; Li, L; Sundt, D; Wang, C; Yang, Y; Zhang, H | 1 |
| Bell, GS; Chinnasami, S; Duncan, JS; Novy, J; Sander, JW; Wehner, T | 1 |
| Bhatnagar, A; Garg, S; Kumar, A; Pottabathini, R | 1 |
| Guo, L; Huang, P; Li, C; Lu, Q; Xu, X; Zhou, M | 1 |
| Chen, F; Chen, X; Gao, Z; Li, X; Nan, F; Pi, X; Wang, L; Xu, H; Zhan, L; Zhang, Y; Zhou, P | 1 |
| Bullman, J; Buraglio, M; Crean, CS; Rayner, K; Tompson, DJ | 1 |
| Hill, MA; Lee, S; Li, M; Tanner, MA; Yang, Y | 1 |
| Cai, J; Fang, D; Li, S; Liu, XD; Ren, J; Xing, GG | 1 |
| Bierbower, SM; Choveau, FS; Lechleiter, JD; Shapiro, MS | 1 |
| Krupa, A; Pietrzak, B; Zwierzyńska, E | 1 |
| Budde, T; Cerina, M; Coulon, P; Göbel, K; Kanyshkova, T; Meuth, P; Meuth, SG; Nguyen, XV; Pape, HC; Seidenbecher, T; Szkudlarek, HJ | 1 |
| Assadpour, E; Boehm, S; Gantumur, E; Hilber, K; Koenig, X; Kubista, H; Meyer, C; Treven, M | 1 |
| Bocchicchio, M; Huber, B | 1 |
| Chen, GD; Salvi, R; Sheppard, AM | 1 |
| Cao, M; Geng, L; Hui, Z; Li, Y; Shi, R; Wang, J; Zhang, W; Zhou, X | 1 |
| Chen, B; Chen, J; Li, H; Sun, R; Wang, F; Wang, X; Zhang, Y | 1 |
| Czuczwar, SJ; Florek-Luszczki, M; Luszczki, JJ; Miziak, B; Zagaja, M | 1 |
| Duignan, KM; Edwards, S; Furuya, T; Kalappa, BI; Soh, H; Tzingounis, AV; Tzounopoulos, T | 1 |
| Chesler, EJ; Gass, JT; Griffin, WC; McGuier, NS; Mulholland, PJ; Padula, AE | 1 |
| Eggan, K; Gardner, JP; McNeish, J; Wainger, BJ; Woolf, CJ | 1 |
| Cheng, Y; Jia, Q; Li, H; Zhang, F; Zhang, H; Zhao, S | 1 |
| Brandt, C; Daniluk, J; DeRossett, S; Edwards, S; Lerche, H; Lotay, N | 1 |
| Abd-Elsayed, AA; Gu, JG; Ikeda, R; Jia, Z; Li, M; Ling, J; Zuo, X | 1 |
| Chen, Y; Cheng, Y; Duan, R; Li, H; Li, J; Yuan, J; Zhao, S | 1 |
| Citraro, R; Coppola, A; De Sarro, G; Del Gaudio, L; Palleria, C; Russo, E; Striano, S | 1 |
| Ahern, CA; Galpin, JD; Kim, RY; Kurata, HT; Pless, SA; Seebohm, G; Yau, MC | 1 |
| Greene, DL; Hoshi, N; Kang, S; Kay, HY; Kosenko, A | 1 |
| Beacher, NG; Brodie, MJ; Goodall, C | 1 |
| Brodie, MJ | 1 |
| Aizawa, N; Homma, Y; Igawa, Y; Kida, J; Matsuya, H; Otsuki, T; Saito, Y; Wakamatsu, D | 1 |
| Montal, M; Santos, JS; Syeda, R | 1 |
| Gu, JG; Kanda, H | 1 |
| Ambrosino, P; Barrese, V; Breschi, MC; Calderone, V; Canduela, MJ; Curtis, MJ; Grandes, P; Greenwood, IA; Martelli, A; Miceli, F; Scorziello, A; Sisalli, MJ; Soldovieri, MV; Taglialatela, M; Testai, L; Vinciguerra, I | 1 |
| Apostolova, E; Kokova, V; Peychev, L; Zagorchev, P | 2 |
| Elger, CE; Graf, W; Hamer, HM; Kasper, B; Kull, A; Kurth, C; Nass, RD; Rosenow, F; Steinhoff, BJ; Strzelczyk, A; Surges, R | 1 |
| Brown, L; Forcelli, PA; Gutherz, S; Kondratyev, A; Kulick, C; Soper, C | 1 |
| Corbin-Leftwich, A; Ha, J; Le, AH; Mossadeq, SM; Ruchala, I; Villalba-Galea, CA | 1 |
| Deshimaru, M; Hirose, S; Ihara, Y; Ishii, A; Tomonoh, Y; Uchida, T; Zhang, B | 1 |
| Forcelli, PA; Frankel, S; Gutherz, S; Kondratyev, A; Kulick, C; Medvedeva, N | 1 |
| Duignan, KM; Hawryluk, JM; Kim, KS; Soh, H; Tzingounis, AV | 1 |
| Aizenman, E; Kumar, M; Liu, R; Reed, N; Tzounopoulos, T; Wipf, P | 1 |
| Abidi, A; Aniksztejn, L; Becq, H; Devaux, J; Lacoste, C; Milh, M; Molinari, F; Roubertie, A; Villard, L | 1 |
| Bernal, L; Lopez-Garcia, JA; Roza, C | 1 |
| Calizo, RC; Chaudhury, D; Dietz, DM; Friedman, AK; Han, MH; Hawkins, A; Juarez, B; Ku, SM; Murrough, JW; Neve, RL; Ribadeneira, M; Walsh, JJ; Wong, EH; Zhang, H; Zhang, S | 1 |
| Gedzelman, ER; Karakis, I; Mauricio, EA; Rudzinski, LA; Shih, JJ; Vélez-Ruiz, NJ | 1 |
| Lopez-Garcia, JA; Rivera-Arconada, I; Vicente-Baz, J | 2 |
| Li, G; Ma, TY; Qi, JL; Song, Y; Teng, BC; Wang, K; Zhang, F; Zhang, HL | 1 |
| Kwan, P; Lim, KS; Lotay, N; White, R | 1 |
| Hansen, HH; Mikkelsen, JD; Mikkelsen, MD; Rode, F; Weikop, P | 1 |
| Bihin, B; de Fays, K; Ossemann, M; Vandermeeren, Y | 1 |
| Kurata, HT; Wang, AW; Yang, R | 1 |
| Bastin, ML; Cook, AM; Oyler, DR; Smetana, KS | 1 |
| Bocksteins, E; Jensen, CS; Schmitt, N; Snyders, DJ; Stas, JI | 1 |
| Carlton, SM; Du, J; Frost, JA; Li, L; Walters, ET; Wu, Z; Xie, F; Yang, Q; Zuo, Y | 1 |
| Byron, KL; Majetschak, M; Nassoiy, SP | 1 |
| Barary, MA; El-Yazbi, AF; Ibrahim, FA; Wagih, MM | 1 |
| Greene, DL; Hoshi, N; Kang, S | 1 |
| Boehm, S; Dominguez-Rodriguez, M; Hilber, K; Koenig, X; Kovar, M; Kubista, H; Rubi, L; Todt, H; Zebedin-Brandl, E | 1 |
| Holt, JC; Jones, TA; Lee, C | 1 |
| Krupa-Burtnik, A; Pietrzak, B; Zwierzyńska, E | 2 |
| Adamczuk, P; Czuczwar, SJ; Florek-Luszczki, M; Kondrat-Wrobel, MW; Luszczki, JJ; Miziak, B; Wroblewska-Luczka, P; Zagaja, M; Zaluska, K | 1 |
| Ambrosino, P; Manocchio, L; Miceli, F; Mosca, I; Soldovieri, MV; Taglialatela, M | 1 |
| Kim, RY; Kurata, HT; Pless, SA | 1 |
| Gautier, NM; Glasscock, E; Mishra, V; Vanhoof-Villalba, SL | 1 |
| Chen, J; Cui, J; Lai, R; Li, B; Liang, P; Lu, Q; Lu, X; Luo, L; Ombati, R; Tian, C; Wang, S; Wang, X; Wu, F; Yang, S; Zhang, L; Zhou, M | 1 |
| Chang, M; Li, C; Lv, C; Song, Z; Tian, X; Xu, H; Xue, W; Zhang, J; Zhang, L; Zhang, X | 1 |
| Buchta, WC; Culver, O; Goswamee, P; Harlan, B; Kalivas, P; Khanna, R; Lauer, A; McKendrick, G; Moutal, A; Parrilla-Carrero, J; Penrod, R; Ramakrishnan, V; Riegel, AC | 1 |
| Ferguson, TA; Franssen, H; Groeneveld, GJ; Heuberger, JAAC; Kovalchuk, MO; Sleutjes, BTHM; van den Berg, LH; Ziagkos, D | 1 |
| Ghezzi, F; Monni, L; Nistri, A | 1 |
| Díaz, AL; Etchenique, R; Murer, MG; Paz, RM; Rela, L; Stahl, A; Tubert, C | 1 |
| Dawson-Scully, K; Jia, K; Kelly, SP; Minnerly, J; Risley, MG | 1 |
| Feng, XM; Li, GB; Liu, JY; Zhang, BL; Zhang, RS | 1 |
| Ammar, T; Kim, RY; Kurata, HT; Li, J; Pless, SA; Wang, CK; Yang, RY; Yau, MC | 1 |
| Abbott, GW; Manville, RW | 1 |
| Ali, MFB; Mohamed, FA; Mostafa, AM; Rageh, AH | 1 |
| Kurata, HT; Lamothe, SM; Wang, AW; Wang, CK; Yang, RY | 1 |
| Ahle, G; Chadha, N; Collins, KA; Costi, S; Do, B; Friedman, AK; Han, MH; Iosifescu, DV; Kautz, M; Morris, LS; Murrough, JW; Nestler, EJ; Pizzagalli, DA; Tan, A; Van Dam, NT; Whitton, AE | 1 |
| Dang, D; Frost, JA; Li, J; Li, L; Yang, Q; Zuo, Y | 1 |
| Diao, Y; Li, J; Luo, Y; Sun, W; Yan, W; Yin, Y | 1 |
| Bonev, AD; Dalsgaard, T; Heppner, TJ; Nelson, MT; Tykocki, NR | 1 |
| Li, SY; Nai, Y; Zhao, YJ; Zheng, YH | 1 |
| Castellino, S; Groseclose, MR | 1 |
| Lee, LY; Lin, AH; Meeker, S; Patil, MJ; Ru, F; Sun, H; Undem, BJ | 1 |
| Denman, KS; Dupont, C; Hawash, AA; Rich, MM; Voss, AA | 1 |
| Bugni, SE; Crowley, NA; Feng, M; Guo, Y; Luscher, B; Patel, A | 1 |
| Burris, KD; Eastwood, BJ; Priest, BT; Sher, E; Wilenkin, B; Williams, AC | 1 |
| Boll, MC; Brickel, N; Cooper, J; Daniluk, J; De'Ath, J; Hewett, K; Joshi, K; McDonald, S; Rayner, K; Tiamkao, S; Vorobyeva, O | 1 |
| Dang, D; Li, L; Wu, Z; Xie, F; Xu, G; Yang, Q | 1 |
| Huo, B; Jin, L; Li, H; Liu, R; Liu, S; Tang, L; Wang, Y; Yang, T; Zhang, F; Zhao, X | 1 |
| An, H; Chen, Y; Geng, Y; Guo, S; Li, J; Pang, C; Qi, J; Shi, S; Sun, F; Wang, X; Zhan, Y; Zhang, H | 1 |
| Dong, H; Feng, S; Lin, L; Liu, Y; Shi, G; Tian, Y; Zhao, F | 1 |
| Karlsson, U; Larsson, JE; Liin, SI; Wu, X | 1 |
| Kurata, HT | 1 |
| Allison, WT; Kanyo, R; Kurata, HT; Li, J; Locskai, LF; Wang, CK | 1 |
| Fu, J; Guo, J; Guo, P; Lai, D; Li, X; Lv, D; Mei, L; Wang, J; Yang, H; Ye, S; Zhang, Q | 1 |
| Ambrosino, P; Binda, A; Canafoglia, L; Castellotti, B; DiFrancesco, JC; Freri, E; Gellera, C; Granata, T; Labalme, A; Lesca, G; Messina, G; Mosca, I; Murano, C; Ragona, F; Rivolta, I; Solazzi, R; Soldovieri, MV; Taglialatela, M; Vannicola, C | 1 |
| Atassi, N; Baloh, RH; Bedlack, R; Berry, JD; Camprodon, JA; Celnik, PA; Chaudhry, V; Cudkowicz, ME; David, WS; Davila-Perez, P; Eggan, K; Evora, A; Gable, K; Goutman, SA; Goyal, NA; Hall, M; Hurtado, A; Juel, VC; Kassis, SB; Kaur, D; Kiernan, MC; Kiskinis, E; Klements, D; Koh, J; La, T; Ladha, SS; Lange, DJ; Lewis, RA; Macklin, EA; Maragakis, NJ; Marei, A; Mauricio, EA; McIlduff, CE; Meehan, S; Oskarsson, B; Paganoni, S; Pascual-Leone, A; Pereira, JD; Phielipp, N; Pothier, L; Rivner, MH; Rosenquist, P; Rutkove, SB; Shefner, JM; Simmons, Z; Vucic, S; Wainger, BJ; Weiss, MD; Woolf, CJ | 1 |
| Li, T; Shen, H; Wang, Y; Wu, K; Yue, Z; Zhang, F | 1 |
| Feng, C; Gao, R; Guo, J; He, Z; Qin, C; Ren, J; Wang, Q; Wang, Z; Zang, L; Zhao, C; Zhu, S | 1 |
| Bagiella, E; Bevilacqua, L; Chadha, N; Collins, KA; Corniquel, M; Costi, S; Han, MH; Hoch, M; Iosifescu, DV; Iqbal, T; Jha, MK; Kirkwood, KA; Mathew, SJ; Morris, LS; Murrough, JW; Parides, MK; Pizzagalli, DA; Salas, R; Stern, ER; Swann, AC; Ursu, S; Vo-Le, B; Whitton, A | 1 |
| Lauritano, A; Taglialatela, M; Tzingounis, AV; Varghese, N | 1 |
| Aiba, I; Noebels, JL | 1 |
| Barker, BS; Berger, K; Dudek, FE; Jackson, CE; McCarren, HS; McDonough, JH; Spampanato, J; Yeung, DT | 1 |
| Chen, F; Gao, ZB; Hu, HN; Liu, HN; Liu, J; Nan, FJ; Pi, XP; Tian, FY; Xu, HY; Zhan, L; Zhang, YM | 1 |
| Deyama, S; Esaki, H; Fukao, A; Izumi, S; Kaneda, K; Nishitani, N | 1 |
| Bankstahl, J; Bankstahl, M; Bloms-Funke, P; Kneip, C; Löscher, W; Schröder, W | 1 |
| Hotta, N; Miyamoto, M; Suzuki, K | 1 |
| Bartz, FM; Bednarski, PJ; Bodtke, A; Link, A; Schulig, L; Wurm, KW | 1 |
| Chavez, A; Cooper, EC; Dunbar, C; Jiang, X; Jing, J; Lee, M; Maheshwari, A; Park, S; Soh, H; Sonesra, A; Tzingounis, AV; Yang, R | 1 |
| Franssen, H; Groeneveld, GJ; Heuberger, JAAC; Kovalchuk, MO; Sleutjes, BTHM; Stikvoort García, DJL; van den Berg, LH | 1 |
| Cannon, SC; DiFranco, M; Quiñonez, M; Wu, F | 1 |
| Bazaldua, II; Belchior, H; Bozdemir, E; Brenner, R; Bugay, V; Cavazos, JE; Chun, SH; Dantas, DC; Farmer, A; Holstein, DM; Lechleiter, JD; Shapiro, MS; Stoja, A; Vigil, FA | 1 |
38 review(s) available for ezogabine and carbamates
| Article | Year |
|---|---|
Is there a role for potassium channel openers in neuronal ion channel disorders?
Topics: Aminopyridines; Animals; Anticonvulsants; Antihypertensive Agents; Ataxia; Carbamates; Diazoxide; Epilepsy; Humans; Ion Channels; Isaacs Syndrome; Membrane Potentials; Mice; Mice, Neurologic Mutants; Mutation; Nervous System Diseases; Neuroprotective Agents; Parkinson Disease; Phenylenediamines; Potassium Channels | 2000 |
Potassium channels: how genetic studies of epileptic syndromes open paths to new therapeutic targets and drugs.
Topics: Animals; Anticonvulsants; Carbamates; Clinical Trials as Topic; Drug Design; Epilepsy; Epilepsy, Benign Neonatal; Humans; Mutation; Neurons; Phenylenediamines; Potassium Channels; Potassium Channels, Voltage-Gated; Receptors, Muscarinic; Synaptic Transmission | 2001 |
Recent developments on KCNQ potassium channel openers.
Topics: Acrylamides; Aminopyridines; Benzamides; Carbamates; Epilepsy; Humans; Indoles; Ion Channel Gating; KCNQ Potassium Channels; KCNQ1 Potassium Channel; Migraine Disorders; Oxindoles; Pain; Phenylenediamines; Potassium Channels, Voltage-Gated | 2005 |
Retigabine: chemical synthesis to clinical application.
Topics: Animals; Anticonvulsants; Anxiety; Carbamates; Dose-Response Relationship, Drug; Epilepsy; Humans; KCNQ Potassium Channels; KCNQ1 Potassium Channel; Neurons; Pain; Phenylenediamines; Potassium Channels, Voltage-Gated; Time Factors | 2005 |
A potassium channel, the M-channel, as a therapeutic target.
Topics: Animals; Carbamates; Central Nervous System Agents; Clinical Trials as Topic; Humans; Indoles; Molecular Structure; Phenylenediamines; Potassium Channels, Voltage-Gated; Pyridines | 2005 |
Retigabine.
Topics: Animals; Anticonvulsants; Brain; Carbamates; Clinical Trials as Topic; Epilepsy; Humans; Phenylenediamines | 2007 |
[A new aspect in the research on antiepileptic drugs].
Topics: Acetamides; Amines; Animals; Anticonvulsants; Benzodiazepines; Carbamates; Cyclohexanecarboxylic Acids; Disease Models, Animal; Drug Design; Gabapentin; gamma-Aminobutyric Acid; Humans; Lacosamide; Levetiracetam; Phenylenediamines; Piracetam; Pregabalin; Pregnanolone; Pyrrolidinones; Triazoles | 2007 |
Molecular pharmacology and therapeutic potential of neuronal Kv7-modulating drugs.
Topics: Aminopyridines; Animals; Binding Sites; Carbamates; Epilepsy, Benign Neonatal; Hearing Loss; Humans; KCNQ Potassium Channels; KCNQ1 Potassium Channel; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Phenylenediamines | 2008 |
Nervous system KV7 disorders: breakdown of a subthreshold brake.
Topics: Anticonvulsants; Carbamates; Epilepsy, Benign Neonatal; Humans; KCNQ Potassium Channels; Mutation; Nervous System Diseases; Peripheral Nervous System Diseases; Phenylenediamines | 2008 |
KV7 channelopathies.
Topics: Animals; Carbamates; Channelopathies; Epilepsy; Humans; KCNQ Potassium Channels; Long QT Syndrome; Mutation; Phenylenediamines | 2010 |
Ezogabine: a novel antiepileptic as adjunctive therapy for partial onset seizures.
Topics: Animals; Anticonvulsants; Carbamates; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Interactions; Epilepsies, Partial; Humans; Phenylenediamines; Time Factors | 2010 |
Retigabine (ezogabine): in partial-onset seizures in adults with epilepsy.
Topics: Anticonvulsants; Carbamates; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Epilepsy; Humans; Phenylenediamines; Randomized Controlled Trials as Topic; Seizures | 2011 |
[New antiepileptic drugs, and therapeutic considerations].
Topics: Acetamides; Anticonvulsants; Carbamates; Dibenzazepines; Epilepsy; Humans; Lacosamide; Phenylenediamines | 2011 |
The mechanism of action of retigabine (ezogabine), a first-in-class K+ channel opener for the treatment of epilepsy.
Topics: Animals; Anticonvulsants; Carbamates; Epilepsy; Humans; KCNQ Potassium Channels; Phenylenediamines; Rats; Treatment Outcome | 2012 |
Pharmacotherapy of the third-generation AEDs: lacosamide, retigabine and eslicarbazepine acetate.
Topics: Acetamides; Anticonvulsants; Carbamates; Dibenzazepines; Drug Interactions; Epilepsy; Humans; Lacosamide; Phenylenediamines | 2012 |
The urinary safety profile and secondary renal effects of retigabine (ezogabine): a first-in-class antiepileptic drug that targets KCNQ (K(v)7) potassium channels.
Topics: Animals; Anticonvulsants; Carbamates; Epilepsies, Partial; Humans; KCNQ Potassium Channels; Muscle, Smooth; Phenylenediamines; Urinary Retention | 2012 |
Retigabine for partial onset seizures.
Topics: Animals; Anticonvulsants; Carbamates; Disease Models, Animal; Epilepsies, Partial; Humans; Phenylenediamines; Randomized Controlled Trials as Topic; Treatment Outcome | 2012 |
[Retigabine. A novel anticonvulsant drug for the adjunctive treatment of partial seizures].
Topics: Animals; Anticonvulsants; Carbamates; Clinical Trials, Phase III as Topic; Epilepsies, Partial; Humans; Phenylenediamines; Potassium Channel Blockers | 2012 |
Recent and future antiepileptic drugs and their impact on cognition: what can we expect?
Topics: Acetamides; Animals; Anticonvulsants; Carbamates; Cognition; Cognition Disorders; Epilepsy; Forecasting; Humans; Lacosamide; Phenylenediamines | 2012 |
Retigabine/Ezogabine, a KCNQ/K(V)7 channel opener: pharmacological and clinical data.
Topics: Animals; Anticonvulsants; Carbamates; Epilepsy; Humans; KCNQ Potassium Channels; Membrane Transport Modulators; Phenylenediamines | 2012 |
One man's side effect is another man's therapeutic opportunity: targeting Kv7 channels in smooth muscle disorders.
Topics: Animals; Anticonvulsants; Carbamates; Constipation; Female; Humans; Hypertension; KCNQ1 Potassium Channel; Membrane Potentials; Membrane Transport Modulators; Muscle Tonus; Muscle, Smooth; Muscle, Smooth, Vascular; Muscular Diseases; Neurons; Obstetric Labor, Premature; Phenylenediamines; Potassium Channels, Voltage-Gated; Pregnancy; Urinary Bladder Diseases | 2013 |
ACS chemical neuroscience molecule spotlight on Potiga (Ezogabine).
Topics: Anticonvulsants; Carbamates; Epilepsy; Humans; KCNQ Potassium Channels; Phenylenediamines; Potassium Channels; Randomized Controlled Trials as Topic; Seizures; United States; United States Food and Drug Administration | 2012 |
The efficacy and safety of retigabine and other adjunctive treatments for refractory partial epilepsy: a systematic review and indirect comparison.
Topics: Anticonvulsants; Carbamates; Disorders of Excessive Somnolence; Epilepsies, Partial; Humans; Phenylenediamines; Randomized Controlled Trials as Topic; Treatment Outcome | 2012 |
Ezogabine (retigabine) and its role in the treatment of partial-onset seizures: a review.
Topics: Animals; Anticonvulsants; Carbamates; Dose-Response Relationship, Drug; Drug Interactions; Epilepsies, Partial; Humans; Phenylenediamines; Potassium Channels, Voltage-Gated | 2012 |
Ezogabine: development and role in the management of epileptic seizures.
Topics: Anticonvulsants; Carbamates; Clinical Trials as Topic; Cytochrome P-450 Enzyme System; Epilepsy; Half-Life; Humans; Phenylenediamines; Potassium Channels | 2013 |
Ezogabine: an evaluation of its efficacy and safety as adjunctive therapy for partial-onset seizures in adults.
Topics: Adult; Animals; Anticonvulsants; Carbamates; Drug Interactions; Epilepsies, Partial; Humans; Phenylenediamines; Treatment Outcome | 2012 |
Retigabine for the adjunctive treatment of adults with partial-onset seizures in epilepsy with and without secondary generalization : a NICE single technology appraisal.
Topics: Adolescent; Adult; Anticonvulsants; Carbamates; Cost-Benefit Analysis; Decision Support Techniques; Drug Industry; Epilepsies, Partial; Humans; Models, Theoretical; Phenylenediamines; Randomized Controlled Trials as Topic; Seizures; Young Adult | 2013 |
Clinical pharmacokinetics of retigabine/ezogabine.
Topics: Age Factors; Aged; Anticonvulsants; Biological Availability; Carbamates; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Interactions; Epilepsies, Partial; Half-Life; Humans; Liver Diseases; Phenylenediamines; Renal Insufficiency | 2013 |
Ezogabine: a novel antiepileptic for adjunctive treatment of partial-onset seizures.
Topics: Animals; Anticonvulsants; Carbamates; Drug Therapy, Combination; Humans; Phenylenediamines; Randomized Controlled Trials as Topic; Seizures | 2013 |
Safety profile of two novel antiepileptic agents approved for the treatment of refractory partial seizures: ezogabine (retigabine) and perampanel.
Topics: Anticonvulsants; Carbamates; Drug Monitoring; Drug Resistance; Epilepsy, Complex Partial; Humans; Nitriles; Patient Selection; Phenylenediamines; Potassium Channels, Voltage-Gated; Pyridones; Receptors, AMPA | 2013 |
[Retigabine - a new antiepileptic drug with a different mechanism of action].
Topics: Adult; Anticonvulsants; Carbamates; Drug Interactions; GABA Modulators; Humans; Lamotrigine; Membrane Transport Modulators; Phenylenediamines; Potassium Channels; Seizures; Triazines | 2013 |
The interaction potential of retigabine (ezogabine) with other antiepileptic drugs.
Topics: Anticonvulsants; Carbamates; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; KCNQ Potassium Channels; Phenylenediamines | 2014 |
[Pharmacovigilance update].
Topics: Aminopyridines; Antibodies, Monoclonal, Murine-Derived; Azithromycin; Benzamides; Carbamates; Cyclopropanes; Humans; Nitrofurantoin; Oligopeptides; Pharmacovigilance; Phenylenediamines; Pyridines; Rituximab; Zolpidem | 2014 |
Perspectives on treatment options for mesial temporal lobe epilepsy with hippocampal sclerosis.
Topics: Acetamides; Anticonvulsants; Carbamates; Clinical Trials as Topic; Dibenzazepines; Epilepsy, Temporal Lobe; Hippocampus; Humans; Lacosamide; Levetiracetam; Nitriles; Phenylenediamines; Piracetam; Pyridones; Sclerosis; Syndrome | 2015 |
Practical Use of Newer Antiepileptic Drugs as Adjunctive Therapy in Focal Epilepsy.
Topics: Acetamides; Adult; Aged; Animals; Anticonvulsants; Carbamates; Dibenzazepines; Drug Resistant Epilepsy; Epilepsies, Partial; Female; Humans; Lacosamide; Male; Middle Aged; Nitriles; Phenylenediamines; Pyridones | 2015 |
New antiepileptic drugs: focus on ezogabine, clobazam, and perampanel.
Topics: Anticonvulsants; Benzodiazepines; Carbamates; Clobazam; Humans; Nitriles; Phenylenediamines; Pyridones; Treatment Outcome | 2016 |
Antiepileptic dosing for critically ill adult patients receiving renal replacement therapy.
Topics: Acetamides; Acute Kidney Injury; Amines; Anticonvulsants; Carbamates; Critical Illness; Cyclohexanecarboxylic Acids; Dibenzazepines; Dose-Response Relationship, Drug; Ethosuximide; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lacosamide; Lamotrigine; Levetiracetam; Phenobarbital; Phenylcarbamates; Phenylenediamines; Phenytoin; Piracetam; Propylene Glycols; Renal Dialysis; Renal Replacement Therapy; Seizures; Topiramate; Triazines; Valproic Acid; Zonisamide | 2016 |
Pharmacological Targeting of Neuronal Kv7.2/3 Channels: A Focus on Chemotypes and Receptor Sites.
Topics: Animals; Carbamates; Epilepsy; Humans; Indoles; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Membrane Transport Modulators; Neurons; Phenylenediamines; Potassium Channel Blockers; Pyridines | 2018 |
25 trial(s) available for ezogabine and carbamates
| Article | Year |
|---|---|
Multiple-dose, linear, dose-proportional pharmacokinetics of retigabine in healthy volunteers.
Topics: Acetylation; Adult; Anticonvulsants; Area Under Curve; Biotransformation; Carbamates; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Double-Blind Method; Half-Life; Humans; Male; Mass Spectrometry; Phenylenediamines; Reproducibility of Results | 2002 |
Effects of age and sex on the disposition of retigabine.
Topics: Adult; Aged; Aged, 80 and over; Aging; Anticonvulsants; Area Under Curve; Carbamates; Creatinine; Female; Half-Life; Humans; Male; Phenylenediamines; Reference Values; Sex Characteristics | 2003 |
Pharmacokinetic interaction between retigabine and lamotrigine in healthy subjects.
Topics: Adult; Anticonvulsants; Area Under Curve; Carbamates; Drug Interactions; Half-Life; Humans; Lamotrigine; Male; Metabolic Clearance Rate; Phenylenediamines; Triazines | 2003 |
Lack of pharmacokinetic interaction between retigabine and phenobarbitone at steady-state in healthy subjects.
Topics: Adult; Anticonvulsants; Carbamates; Dose-Response Relationship, Drug; Drug Interactions; Half-Life; Humans; Male; Middle Aged; Phenobarbital; Phenylenediamines; Prospective Studies | 2003 |
N-Glucuronidation of the antiepileptic drug retigabine: results from studies with human volunteers, heterologously expressed human UGTs, human liver, kidney, and liver microsomal membranes of Crigler-Najjar type II.
Topics: Anticonvulsants; Carbamates; Carbon Isotopes; Cell Line; Chromatography, High Pressure Liquid; Crigler-Najjar Syndrome; Drug Interactions; Glucuronides; Humans; Kidney; Kinetics; Liver; Male; Mass Spectrometry; Microsomes; Monosaccharide Transport Proteins; Phenylenediamines | 2006 |
An exploratory open trial on safety and efficacy of the anticonvulsant retigabine in acute manic patients.
Topics: Acute Disease; Adult; Anticonvulsants; Bipolar Disorder; Carbamates; Female; Humans; Male; Middle Aged; Patient Dropouts; Phenylenediamines; Pilot Projects; Psychiatric Status Rating Scales; Treatment Outcome | 2006 |
Randomized, multicenter, dose-ranging trial of retigabine for partial-onset seizures.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Australia; Carbamates; Dose-Response Relationship, Drug; Epilepsies, Partial; Europe; Female; Humans; Male; Middle Aged; Phenylenediamines; Risk Assessment; Risk Factors; Treatment Outcome; United States | 2007 |
Efficacy and safety of adjunctive ezogabine (retigabine) in refractory partial epilepsy.
Topics: Adult; Anticonvulsants; Carbamates; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Epilepsies, Partial; Female; Humans; Male; Middle Aged; Outcome Assessment, Health Care; Phenylenediamines; Prospective Studies; Treatment Outcome | 2010 |
Randomized, double-blind, placebo-controlled trial of ezogabine (retigabine) in partial epilepsy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamates; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Epilepsies, Partial; Female; Humans; Male; Middle Aged; Phenylenediamines; Treatment Outcome | 2011 |
Retigabine as adjunctive therapy in adults with partial-onset seizures: integrated analysis of three pivotal controlled trials.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamates; Double-Blind Method; Endpoint Determination; Epilepsies, Partial; Female; Humans; Male; Middle Aged; Phenylenediamines; Treatment Outcome; Vital Signs; Young Adult | 2012 |
Safety and efficacy of ezogabine (retigabine) in adults with refractory partial-onset seizures: Interim results from two ongoing open-label studies.
Topics: Adult; Anticonvulsants; Carbamates; Dizziness; Drug Resistance; Epilepsies, Partial; Fatigue; Female; Headache; Humans; Male; Middle Aged; Phenylenediamines; Sleep Stages; Time; Treatment Outcome; Young Adult | 2012 |
The effects of ethanol on the pharmacokinetics, pharmacodynamics, safety, and tolerability of ezogabine (retigabine).
Topics: Adult; Anticonvulsants; Area Under Curve; Attention; Carbamates; Cross-Over Studies; Dizziness; Double-Blind Method; Drug Interactions; Ethanol; Female; Humans; Least-Squares Analysis; Male; Metabolic Clearance Rate; Middle Aged; Phenylenediamines; Postural Balance; Psychomotor Performance; Reaction Time; Vision, Ocular; Young Adult | 2013 |
Efficacy and tolerability exposure-response relationship of retigabine (ezogabine) immediate-release tablets in patients with partial-onset seizures.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamates; Disorders of Excessive Somnolence; Dizziness; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Epilepsies, Partial; Female; Gait Disorders, Neurologic; Humans; Male; Middle Aged; Phenylenediamines; Tablets; Treatment Outcome; Young Adult | 2013 |
The effect of ezogabine on the pharmacokinetics of an oral contraceptive agent.
Topics: Adolescent; Adult; Anticonvulsants; Carbamates; Contraceptives, Oral, Combined; Drug Interactions; Ethinyl Estradiol; Female; Humans; Middle Aged; Norethindrone; Phenylenediamines; Young Adult | 2013 |
Safety and tolerability of different titration rates of retigabine (ezogabine) in patients with partial-onset seizures.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamates; Dose-Response Relationship, Drug; Double-Blind Method; Epilepsies, Partial; Female; Humans; Male; Middle Aged; Phenylenediamines; Treatment Outcome | 2013 |
A novel design for a dose finding, safety, and drug interaction study of an antiepileptic drug (retigabine) in early clinical development.
Topics: Adolescent; Adult; Anticonvulsants; Carbamates; Drug Administration Schedule; Drug Dosage Calculations; Drug Interactions; Drug Therapy, Combination; Epilepsies, Partial; Epilepsy, Generalized; Female; Humans; Male; Maximum Tolerated Dose; Middle Aged; Patient Safety; Phenylenediamines; Research Design; Risk Assessment; Time Factors; Treatment Outcome; United States; Young Adult | 2014 |
Effect of hemodialysis on pharmacokinetics of ezogabine/retigabine and its N-acetyl metabolite in patients with end stage renal disease.
Topics: Adult; Aged; Anticonvulsants; Area Under Curve; Carbamates; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Phenylenediamines; Renal Dialysis | 2014 |
Efficacy and safety of ezogabine/retigabine as adjunctive therapy to specified single antiepileptic medications in an open-label study of adults with partial-onset seizures.
Topics: Aged; Anticonvulsants; Carbamates; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilepsies, Partial; Female; Humans; Kaplan-Meier Estimate; Lamotrigine; Levetiracetam; Male; Middle Aged; Oxcarbazepine; Phenylenediamines; Piracetam; Seizures; Treatment Outcome; Triazines; Valproic Acid | 2015 |
Efficacy and safety of retigabine/ezogabine as adjunctive therapy in adult Asian patients with drug-resistant partial-onset seizures: A randomized, placebo-controlled Phase III study.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamates; Double-Blind Method; Drug Resistant Epilepsy; Epilepsies, Partial; Female; Humans; Male; Middle Aged; Phenylenediamines; Seizures; Skin Pigmentation; Treatment Outcome; Young Adult | 2016 |
Effect of a single dose of retigabine in cortical excitability parameters: A cross-over, double-blind placebo-controlled TMS study.
Topics: Adult; Analysis of Variance; Anticonvulsants; Carbamates; Cross-Over Studies; Double-Blind Method; Electromyography; Female; Humans; Male; Motor Cortex; Movement; Muscle, Skeletal; Phenylenediamines; Rest; Transcranial Magnetic Stimulation | 2016 |
Acute Effects of Riluzole and Retigabine on Axonal Excitability in Patients With Amyotrophic Lateral Sclerosis: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Axons; Carbamates; Cross-Over Studies; Double-Blind Method; Electromyography; Evoked Potentials, Motor; Excitatory Amino Acid Antagonists; Female; Humans; Male; Middle Aged; Motor Neurons; Netherlands; Neuroprotective Agents; Phenylenediamines; Refractory Period, Electrophysiological; Riluzole; Time Factors; Treatment Outcome | 2018 |
Effects of the KCNQ channel opener ezogabine on functional connectivity of the ventral striatum and clinical symptoms in patients with major depressive disorder.
Topics: Carbamates; Depressive Disorder, Major; Female; Humans; Ion Channel Gating; KCNQ Potassium Channels; Magnetic Resonance Imaging; Male; Middle Aged; Phenylenediamines; Reward; Ventral Striatum | 2020 |
Safety of retigabine in adults with partial-onset seizures after long-term exposure: focus on unexpected ophthalmological and dermatological events.
Topics: Adult; Anticonvulsants; Carbamates; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Eye Diseases; Female; Follow-Up Studies; Humans; Male; Middle Aged; Phenylenediamines; Seizures; Skin Diseases; Treatment Outcome | 2020 |
Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial.
Topics: Aged; Amyotrophic Lateral Sclerosis; Anticonvulsants; Carbamates; Cerebral Cortex; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Motor Neurons; Phenylenediamines; Spinal Cord; Treatment Outcome | 2021 |
Impact of the KCNQ2/3 Channel Opener Ezogabine on Reward Circuit Activity and Clinical Symptoms in Depression: Results From a Randomized Controlled Trial.
Topics: Adult; Anhedonia; Carbamates; Depressive Disorder; Depressive Disorder, Major; Double-Blind Method; Female; Functional Neuroimaging; Humans; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Magnetic Resonance Imaging; Male; Membrane Transport Modulators; Middle Aged; Phenylenediamines; Reward; Ventral Striatum | 2021 |
271 other study(ies) available for ezogabine and carbamates
| Article | Year |
|---|---|
Anticonvulsant properties of D-20443 in genetically epilepsy-prone rats: prediction of clinical response.
Topics: Animals; Anticonvulsants; Carbamates; Dose-Response Relationship, Drug; Epilepsy; Female; Male; Phenylenediamines; Rats; Rats, Inbred Strains | 1995 |
D-23129: a new anticonvulsant with a broad spectrum activity in animal models of epileptic seizures.
Topics: Administration, Oral; Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Carbamates; Dyskinesia, Drug-Induced; Electroshock; Female; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Pentylenetetrazole; Phenylenediamines; Postural Balance; Rats; Rats, Wistar; Seizures; Strychnine | 1996 |
D-23129: a potent anticonvulsant in the amygdala kindling model of complex partial seizures.
Topics: Animals; Anticonvulsants; Carbamates; Female; Kindling, Neurologic; Phenylenediamines; Rats; Rats, Wistar; Seizures; Valproic Acid | 1996 |
Progress report on new antiepileptic drugs: a summary of the Third Eilat Conference.
Topics: Acetamides; Animals; Anticonvulsants; Azetidines; Carbamates; Drug Evaluation, Preclinical; Drugs, Investigational; Epilepsy; Humans; Israel; Levetiracetam; Nipecotic Acids; Phenylenediamines; Piracetam; Product Surveillance, Postmarketing; Randomized Controlled Trials as Topic; Thiazoles; Tiagabine; Triazoles | 1996 |
The effects of D-23129, a new experimental anticonvulsant drug, on neurotransmitter amino acids in the rat hippocampus in vitro.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Carbamates; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; Nerve Tissue Proteins; Neurotransmitter Agents; Phenylenediamines; Rats; Rats, Inbred Strains; Tetrodotoxin | 1995 |
In vitro glucuronidation of D-23129, a new anticonvulsant, by human liver microsomes and liver slices.
Topics: Anticonvulsants; Carbamates; Drug Evaluation, Preclinical; Glucuronates; Humans; In Vitro Techniques; Kinetics; Liver; Microsomes, Liver; Phenylenediamines; Regression Analysis | 1997 |
The new anticonvulsant retigabine (D-23129) acts as an opener of K+ channels in neuronal cells.
Topics: Animals; Anticonvulsants; Carbamates; Humans; Mice; Neurons; Patch-Clamp Techniques; Phenylenediamines; Potassium Channels; Rats; Tumor Cells, Cultured | 1997 |
Effects of retigabine (D-23129) on different patterns of epileptiform activity induced by 4-aminopyridine in rat entorhinal cortex hippocampal slices.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Bicuculline; Carbamates; Convulsants; Electrophysiology; Entorhinal Cortex; Epilepsy; Excitatory Amino Acid Antagonists; In Vitro Techniques; Phenylenediamines; Rats; Rats, Wistar; Seizures | 1999 |
Retigabine N-glucuronidation and its potential role in enterohepatic circulation.
Topics: Animals; Anticonvulsants; Carbamates; Chromatography, High Pressure Liquid; Dogs; Enterohepatic Circulation; Glucuronates; Humans; Individuality; Isoenzymes; Kinetics; Male; Microsomes, Liver; Phenylenediamines; Rats; Rats, Gunn; Rats, Wistar | 1999 |
Metabolism of retigabine (D-23129), a novel anticonvulsant.
Topics: Animals; Anticonvulsants; Bile; Carbamates; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Dogs; Glucuronates; Humans; Male; Microsomes, Liver; Nuclear Magnetic Resonance, Biomolecular; Phenylenediamines; Radiometry; Rats; Rats, Wistar | 1999 |
Characterization of the K+ channel opening effect of the anticonvulsant retigabine in PC12 cells.
Topics: Animals; Anticonvulsants; Carbamates; Cells, Cultured; Electrophysiology; Epilepsy; Nerve Growth Factor; PC12 Cells; Phenylenediamines; Potassium Channels; Rats | 1999 |
The anticonvulsant retigabine potently suppresses epileptiform discharges in the low Ca ++ and low Mg++ model in the hippocampal slice preparation.
Topics: Animals; Anticonvulsants; Calcium; Carbamates; Electrophysiology; Epilepsy; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Magnesium Deficiency; Male; Phenylenediamines; Potassium Channels; Rats; Rats, Wistar | 2000 |
Retigabine strongly reduces repetitive firing in rat entorhinal cortex.
Topics: Animals; Anticonvulsants; Carbamates; Electrophysiology; Entorhinal Cortex; Excitatory Postsynaptic Potentials; Female; In Vitro Techniques; Male; Membrane Potentials; Neurons; Phenylenediamines; Rats; Rats, Wistar | 1999 |
Effects of retigabine (D-23129) on different patterns of epileptiform activity induced by low magnesium in rat entorhinal cortex hippocampal slices.
Topics: Animals; Anticonvulsants; Carbamates; Disease Models, Animal; Electroencephalography; Entorhinal Cortex; Epilepsy; Hippocampus; Magnesium Deficiency; Phenylenediamines; Rats; Rats, Wistar | 2000 |
The novel anticonvulsant retigabine activates M-currents in Chinese hamster ovary-cells tranfected with human KCNQ2/3 subunits.
Topics: Animals; Anticonvulsants; Carbamates; CHO Cells; Cricetinae; Humans; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Patch-Clamp Techniques; Phenylenediamines; Potassium Channels; Potassium Channels, Voltage-Gated; Transfection | 2000 |
Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine.
Topics: Animals; Anticonvulsants; Carbamates; CHO Cells; Cricetinae; Electrophysiology; Humans; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Oocytes; Patch-Clamp Techniques; Phenylenediamines; Potassium Channels; Potassium Channels, Voltage-Gated; Transfection; Xenopus | 2000 |
Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels.
Topics: Animals; Anticonvulsants; Barium; Carbamates; Cell Differentiation; Cell Line; CHO Cells; Cricetinae; Drug Interactions; Electrophysiology; Humans; Indoles; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; PC12 Cells; Phenylenediamines; Potassium; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Rats; Transfection | 2000 |
Flupirtine and retigabine prevent L-glutamate toxicity in rat pheochromocytoma PC 12 cells.
Topics: Aminopyridines; Analgesics; Animals; Antidepressive Agents; Carbamates; Cell Death; Clorgyline; Culture Media; Cystine; Dopamine Agents; Excitatory Amino Acid Antagonists; Glutamic Acid; Glutathione; Levodopa; Monoamine Oxidase; Monoamine Oxidase Inhibitors; PC12 Cells; Phenylenediamines; Rats; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate | 2000 |
A neurochemical study of the novel antiepileptic drug retigabine in mouse brain.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Brain Chemistry; Carbamates; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Glutamine; Male; Mice; Mice, Inbred ICR; Phenylenediamines | 2000 |
Determination of retigabine and its acetyl metabolite in biological matrices by on-line solid-phase extraction (column switching) liquid chromatography with tandem mass spectrometry.
Topics: Anticonvulsants; Calibration; Carbamates; Chromatography, High Pressure Liquid; Mass Spectrometry; Phenylenediamines; Reproducibility of Results; Sensitivity and Specificity | 2000 |
Characterization of KCNQ5/Q3 potassium channels expressed in mammalian cells.
Topics: Animals; Anticonvulsants; Barium; Carbamates; CHO Cells; Cricetinae; Electrophysiology; Indoles; KCNQ3 Potassium Channel; Oocytes; Patch-Clamp Techniques; Phenylenediamines; Plasmids; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Xenopus laevis | 2001 |
Investigations into the mechanism of action of the new anticonvulsant retigabine. Interaction with GABAergic and glutamatergic neurotransmission and with voltage gated ion channels.
Topics: Animals; Anticonvulsants; Calcium Channels; Carbamates; Cells, Cultured; Excitatory Amino Acid Agonists; Female; gamma-Aminobutyric Acid; Glutamic Acid; Ion Channel Gating; Kainic Acid; Neurons; Patch-Clamp Techniques; Phenylenediamines; Rats; Sodium Channels; Synaptic Transmission | 2000 |
Influence of retigabine on the anticonvulsant activity of some antiepileptic drugs against audiogenic seizures in DBA/2 mice.
Topics: Animals; Anticonvulsants; Body Temperature; Carbamates; Dose-Response Relationship, Drug; Drug Synergism; Female; Male; Mice; Mice, Inbred DBA; Motor Activity; Phenylenediamines; Seizures | 2001 |
Effects of retigabine on rhythmic synchronous activity of human neocortical slices.
Topics: Action Potentials; Adolescent; Adult; Anticonvulsants; Bicuculline; Carbamates; Child; Child, Preschool; Epilepsies, Partial; Female; GABA Antagonists; Humans; Magnesium; Male; Neocortex; Phenylenediamines | 2001 |
KCNQ4 channel activation by BMS-204352 and retigabine.
Topics: Anticonvulsants; Carbamates; Cell Line; Dose-Response Relationship, Drug; Humans; Indoles; KCNQ Potassium Channels; Phenylenediamines; Potassium Channels; Potassium Channels, Voltage-Gated | 2001 |
Activation of expressed KCNQ potassium currents and native neuronal M-type potassium currents by the anti-convulsant drug retigabine.
Topics: Action Potentials; Animals; Anticonvulsants; Carbamates; Cells, Cultured; CHO Cells; Cricetinae; Humans; Indoles; Ion Transport; KCNQ Potassium Channels; KCNQ1 Potassium Channel; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Muscarinic Agonists; Neurons; Patch-Clamp Techniques; Phenylenediamines; Potassium; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1; Receptors, Muscarinic; Superior Cervical Ganglion; Sympathetic Nervous System; Transfection | 2001 |
Activation of KCNQ5 channels stably expressed in HEK293 cells by BMS-204352.
Topics: Anthracenes; Carbamates; Cell Line; Dose-Response Relationship, Drug; Gene Expression; Humans; Indoles; KCNQ Potassium Channels; Membrane Potentials; Phenylenediamines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines | 2002 |
Effects of the anticonvulsant retigabine on cultured cortical neurons: changes in electroresponsive properties and synaptic transmission.
Topics: Animals; Anticonvulsants; Carbamates; Cerebral Cortex; Electrophysiology; Excitatory Postsynaptic Potentials; Mice; Neuronal Plasticity; Neurons; Phenylenediamines; Synaptic Transmission | 2002 |
Delayed sclerosis, neuroprotection, and limbic epileptogenesis after status epilepticus in the rat.
Topics: Animals; Anticonvulsants; Apoptosis; Biomarkers; Carbamates; Caspase Inhibitors; Dizocilpine Maleate; Enzyme Inhibitors; Epilepsy; Female; Hippocampus; Limbic System; Neuroprotective Agents; Phenylenediamines; Rats; Rats, Wistar; Sclerosis; Status Epilepticus; Time Factors | 2002 |
Neuroprotective effects of anticonvulsants in rat hippocampal slice cultures exposed to oxygen/glucose deprivation.
Topics: Acetates; Amines; Animals; Anticonvulsants; Carbamates; Carbamazepine; Cell Death; Cells, Cultured; Chlordiazepoxide; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Ethosuximide; Felbamate; Gabapentin; gamma-Aminobutyric Acid; Glucose; Hippocampus; Hypoxia; Ischemia; Lamotrigine; Levetiracetam; Midazolam; Neurons; Neuroprotective Agents; Nipecotic Acids; Oxcarbazepine; Phenobarbital; Phenylcarbamates; Phenylenediamines; Phenytoin; Piracetam; Propylene Glycols; Rats; Rats, Wistar; Tiagabine; Triazines; Valproic Acid | 2003 |
The anticonvulsant retigabine attenuates nociceptive behaviours in rat models of persistent and neuropathic pain.
Topics: Animals; Anthracenes; Anticonvulsants; Behavior, Animal; Carbamates; Disease Models, Animal; Dose-Response Relationship, Drug; Hindlimb; Male; Neuralgia; Pain Measurement; Phenylenediamines; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Time Factors | 2003 |
Synergy between retigabine and GABA in modulating the convulsant site of the GABAA receptor complex.
Topics: Animals; Anticonvulsants; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Carbamates; Dose-Response Relationship, Drug; Drug Synergism; gamma-Aminobutyric Acid; Kinetics; Models, Biological; Phenylenediamines; Rats; Rats, Wistar; Receptors, GABA-A; Tritium | 2003 |
Effect of the KCNQ potassium channel opener retigabine on single KCNQ2/3 channels expressed in CHO cells.
Topics: Animals; Anticonvulsants; Carbamates; CHO Cells; Cricetinae; Humans; Ion Channel Gating; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Kinetics; Phenylenediamines; Potassium Channels; Potassium Channels, Voltage-Gated; Transfection | 2003 |
A medium-throughput functional assay of KCNQ2 potassium channels using rubidium efflux and atomic absorption spectrometry.
Topics: Anthracenes; Carbamates; Cell Line; Clone Cells; Dose-Response Relationship, Drug; Humans; Indoles; KCNQ2 Potassium Channel; Kinetics; Phenylenediamines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Potassium Chloride; Pyridines; Quaternary Ammonium Compounds; Rubidium; Spectrophotometry, Atomic; Tetraethylammonium; Transfection | 2003 |
KCNQ/M currents in sensory neurons: significance for pain therapy.
Topics: Animals; Anthracenes; Anura; Carbamates; Cells, Cultured; CHO Cells; Cricetinae; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Indoles; Male; Neurons, Afferent; Oocytes; Pain; Pain Management; Pain Measurement; Patch-Clamp Techniques; Phenylenediamines; Potassium Channel Blockers; Potassium Channels; Pyridines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Transfection | 2003 |
Activation of M1 muscarinic receptors triggers transmitter release from rat sympathetic neurons through an inhibition of M-type K+ channels.
Topics: Animals; Animals, Newborn; Carbamates; Cells, Cultured; Evoked Potentials; Mecamylamine; Membrane Potentials; Muscarinic Agonists; Neurons; Norepinephrine; Oxotremorine; Pertussis Toxin; Phenylenediamines; Potassium Channels, Voltage-Gated; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1; Superior Cervical Ganglion; Tetrodotoxin | 2003 |
M channels containing KCNQ2 subunits modulate norepinephrine, aspartate, and GABA release from hippocampal nerve terminals.
Topics: Aminopyridines; Animals; Anthracenes; Anticonvulsants; Aspartic Acid; Carbamates; CHO Cells; Cricetinae; gamma-Aminobutyric Acid; Hippocampus; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Male; Norepinephrine; Patch-Clamp Techniques; Phenylenediamines; Potassium; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Presynaptic Terminals; Protein Subunits; Rats; Synaptosomes | 2004 |
A four-ligand hypercube model to quantify allosteric interactions within the GABAA receptor complex.
Topics: Allosteric Site; Animals; Binding Sites; Carbamates; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Ligands; Models, Chemical; Models, Molecular; Models, Neurological; Phenylenediamines; Prosencephalon; Rats; Rats, Wistar; Receptors, GABA-A | 2004 |
Modulation of KCNQ4 channel activity by changes in cell volume.
Topics: Calcium; Carbamates; Cell Line; Cell Size; Cyclic AMP-Dependent Protein Kinases; Humans; Indoles; KCNQ Potassium Channels; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Osmolar Concentration; Patch-Clamp Techniques; Phenylenediamines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Kinase C; Pyridines; Signal Transduction | 2004 |
M-current modulators alter rat spinal nociceptive transmission: an electrophysiological study in vitro.
Topics: Animals; Anthracenes; Carbamates; Electrophysiology; Female; In Vitro Techniques; Male; Nerve Fibers; Pain Measurement; Phenylenediamines; Potassium Channels, Voltage-Gated; Rats; Rats, Wistar; Spinal Cord; Synaptic Transmission | 2004 |
The anti-hyperalgesic activity of retigabine is mediated by KCNQ potassium channel activation.
Topics: Acute Disease; Amines; Analgesics, Opioid; Animals; Carbamates; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Indoles; Ion Channel Gating; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Male; Mice; Peripheral Nervous System Diseases; Phenylenediamines; Physical Stimulation; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Pyridines; Rats; Rats, Wistar; Spinal Nerves; Touch; Tramadol | 2004 |
KCNQ/M channels control spike afterdepolarization and burst generation in hippocampal neurons.
Topics: Action Potentials; Animals; Anthracenes; Carbamates; Hippocampus; In Vitro Techniques; Indoles; Neurons; Phenylenediamines; Potassium; Potassium Channel Blockers; Potassium Channels; Pyramidal Cells; Pyridines; Rats | 2004 |
The KCNQ channel activator retigabine blocks haloperidol-induced c-Fos expression in the striatum of the rat.
Topics: Animals; Anticonvulsants; Carbamates; Cell Count; Corpus Striatum; Dopamine Antagonists; Drug Administration Schedule; Drug Interactions; Gene Expression Regulation; Haloperidol; Immunohistochemistry; KCNQ Potassium Channels; KCNQ1 Potassium Channel; Male; Phenylenediamines; Potassium Channels; Potassium Channels, Voltage-Gated; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar | 2004 |
Retigabine stimulates human KCNQ2/Q3 channels in the presence of bupivacaine.
Topics: Anesthetics, Local; Animals; Bupivacaine; Carbamates; CHO Cells; Cricetinae; Humans; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Kinetics; Membrane Potentials; Neurotoxicity Syndromes; Patch-Clamp Techniques; Phenylenediamines; Potassium Channels; Potassium Channels, Voltage-Gated | 2004 |
Mice carrying the szt1 mutation exhibit increased seizure susceptibility and altered sensitivity to compounds acting at the m-channel.
Topics: Animals; Anticonvulsants; Carbamates; Disease Models, Animal; Electroshock; Female; Genetic Predisposition to Disease; Indoles; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Mutant Strains; Mutation; Nerve Tissue Proteins; Phenylenediamines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Receptors, Nicotinic; Seizures; Sequence Deletion | 2004 |
Urodynamic effects of the K+ channel (KCNQ) opener retigabine in freely moving, conscious rats.
Topics: Animals; Carbamates; Consciousness; Female; Movement; Phenylenediamines; Potassium Channels; Rats; Rats, Sprague-Dawley; Urodynamics | 2004 |
Meclofenamic acid and diclofenac, novel templates of KCNQ2/Q3 potassium channel openers, depress cortical neuron activity and exhibit anticonvulsant properties.
Topics: Action Potentials; Animals; Anticonvulsants; Carbamates; Cerebral Cortex; CHO Cells; Cricetinae; Diclofenac; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Meclofenamic Acid; Phenylenediamines; Potassium Channels, Voltage-Gated; Rats; Rats, Sprague-Dawley | 2005 |
The new anticonvulsant retigabine favors voltage-dependent opening of the Kv7.2 (KCNQ2) channel by binding to its activation gate.
Topics: Amino Acid Sequence; Animals; Anticonvulsants; Binding Sites; Carbamates; Female; Ion Channel Gating; KCNQ Potassium Channels; KCNQ1 Potassium Channel; KCNQ2 Potassium Channel; Molecular Sequence Data; Phenylenediamines; Point Mutation; Potassium Channels, Voltage-Gated; Xenopus laevis | 2005 |
Anxiolytic effects of Maxipost (BMS-204352) and retigabine via activation of neuronal Kv7 channels.
Topics: Algorithms; Animals; Anti-Anxiety Agents; Anxiety; Ataxia; Behavior, Animal; Carbamates; Cell Line; Dose-Response Relationship, Drug; Emotions; Exploratory Behavior; Female; Hand Strength; Indoles; KCNQ Potassium Channels; KCNQ1 Potassium Channel; Male; Membrane Potentials; Mice; Neurons; Oocytes; Patch-Clamp Techniques; Phenylenediamines; Potassium Channels, Voltage-Gated; Rats; Rats, Wistar; Receptors, GABA-A; RNA, Complementary; Stereoisomerism; Xenopus laevis | 2005 |
Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine.
Topics: Animals; Anticonvulsants; Carbamates; Cloning, Molecular; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Electric Stimulation; Humans; KCNQ Potassium Channels; Membrane Potentials; Microinjections; Models, Molecular; Mutagenesis; Oocytes; Patch-Clamp Techniques; Phenylenediamines; Point Mutation; Protein Structure, Tertiary; Sequence Alignment; Tryptophan; Xenopus | 2005 |
Presynaptic inhibition of transmitter release from rat sympathetic neurons by bradykinin.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Calcium Channels; Carbamates; Cells, Cultured; Cyclooxygenase Inhibitors; Electric Conductivity; Electric Stimulation; Enzyme Activation; Ganglia, Sympathetic; Neurons; Norepinephrine; Phenylenediamines; Potassium; Potassium Channels; Presynaptic Terminals; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Signal Transduction; Time Factors; Tritium | 2005 |
Effects of anticonvulsants on soman-induced epileptiform activity in the guinea-pig in vitro hippocampus.
Topics: Amines; Animals; Anticonvulsants; Carbamates; Carbamazepine; Chlormethiazole; Clozapine; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Levetiracetam; Male; Phenylcarbamates; Phenylenediamines; Piracetam; Propylene Glycols; Soman; Topiramate | 2005 |
Effects of retigabine on the neurodegeneration and extracellular glutamate changes induced by 4-aminopyridine in rat hippocampus in vivo.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Carbamates; Drug Interactions; Electroencephalography; Extracellular Space; Glutamic Acid; Hippocampus; Male; Microdialysis; Neurodegenerative Diseases; Phenylenediamines; Rats; Rats, Wistar | 2005 |
Effects of M-current modulators on the excitability of immature rat spinal sensory and motor neurones.
Topics: Action Potentials; Analysis of Variance; Animals; Animals, Newborn; Anthracenes; Anticonvulsants; Carbamates; Dose-Response Relationship, Radiation; Electric Stimulation; Female; In Vitro Techniques; Male; Membrane Potentials; Motor Neurons; Neurons, Afferent; Phenylenediamines; Potassium Channels, Voltage-Gated; Rats; Reaction Time; Spinal Cord; Synaptic Transmission; Time Factors | 2005 |
KCNQ/Kv7 channel regulation of hippocampal gamma-frequency firing in the absence of synaptic transmission.
Topics: Action Potentials; Animals; Anthracenes; Calcium; Carbamates; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Hippocampus; In Vitro Techniques; Indoles; KCNQ Potassium Channels; Male; Neurons; Periodicity; Phenylenediamines; Potassium; Potassium Channel Blockers; Pyridines; Rats; Synaptic Transmission | 2006 |
Retigabine and flupirtine exert neuroprotective actions in organotypic hippocampal cultures.
Topics: Aminopyridines; Animals; Carbamates; Culture Media, Serum-Free; Glucose; Hippocampus; KCNQ Potassium Channels; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Oxygen; Phenylenediamines; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; Tissue Culture Techniques | 2006 |
The KCNQ channel opener retigabine inhibits the activity of mesencephalic dopaminergic systems of the rat.
Topics: Animals; Anthracenes; Carbamates; Dopamine; Dopamine Antagonists; Haloperidol; KCNQ Potassium Channels; Male; Mesencephalon; Phenylenediamines; Phosphorylation; Protein Subunits; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Substantia Nigra; Tyrosine 3-Monooxygenase; Ventral Tegmental Area | 2006 |
Retigabine: in partial seizures.
Topics: Animals; Anticonvulsants; Carbamates; Epilepsies, Partial; Humans; Phenylenediamines | 2006 |
Kv7/KCNQ/M-channels in rat glutamatergic hippocampal axons and their role in regulation of excitability and transmitter release.
Topics: 4-Aminopyridine; Action Potentials; Animals; Anthracenes; Anticonvulsants; Axons; Carbamates; Electrophysiology; Excitatory Postsynaptic Potentials; Hippocampus; KCNQ Potassium Channels; Male; Models, Theoretical; Phenylenediamines; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Rats; Rats, Wistar; Synaptic Transmission | 2006 |
Retigabine-induced population primary afferent hyperpolarisation in vitro.
Topics: Action Potentials; Afferent Pathways; Animals; Animals, Newborn; Anthracenes; Anticonvulsants; Carbamates; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; Ganglia, Spinal; Glutamates; In Vitro Techniques; Male; Phenylenediamines; Picrotoxin; Rats; Rats, Wistar; Spinal Cord | 2006 |
Antidystonic effects of Kv7 (KCNQ) channel openers in the dt sz mutant, an animal model of primary paroxysmal dystonia.
Topics: Animals; Carbamates; Cricetinae; Disease Models, Animal; Dystonia; Mesocricetus; Phenylenediamines; Potassium Channels | 2006 |
Somatodendritic Kv7/KCNQ/M channels control interspike interval in hippocampal interneurons.
Topics: Action Potentials; Animals; Anthracenes; Carbamates; Cell Line; Computer Simulation; Dendrites; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Green Fluorescent Proteins; Hippocampus; Humans; Immunohistochemistry; In Vitro Techniques; Indoles; Interneurons; KCNQ Potassium Channels; Membrane Potentials; Mice; Mice, Transgenic; Models, Neurological; Patch-Clamp Techniques; Phenylenediamines; Potassium Channel Blockers; Pyridines; Tetraethylammonium; Transfection | 2006 |
Kv7.2-7.5 voltage-gated potassium channel (KCNQ2-5) opener, retigabine, reduces capsaicin-induced visceral pain in mice.
Topics: Animals; Anticonvulsants; Capsaicin; Carbamates; Colon; KCNQ2 Potassium Channel; Male; Mice; Mice, Inbred ICR; Nociceptors; Pain; Pain Measurement; Pain Threshold; Phenylenediamines; Reaction Time; Sensory Receptor Cells; Visceral Afferents | 2007 |
Recruitment of apical dendritic T-type Ca2+ channels by backpropagating spikes underlies de novo intrinsic bursting in hippocampal epileptogenesis.
Topics: Amiloride; Animals; Calcium; Calcium Channels, R-Type; Calcium Channels, T-Type; Carbamates; Dendrites; Male; Nickel; Phenylenediamines; Phorbol 12,13-Dibutyrate; Pyramidal Cells; Rats; Recruitment, Neurophysiological; Riluzole; Sodium; Spider Venoms; Status Epilepticus; Tetrodotoxin | 2007 |
M-channels (Kv7/KCNQ channels) that regulate synaptic integration, excitability, and spike pattern of CA1 pyramidal cells are located in the perisomatic region.
Topics: Action Potentials; Animals; Anthracenes; Calcium; Carbamates; Cerebral Cortex; Computer Simulation; Dendrites; Electrophysiology; Excitatory Postsynaptic Potentials; Extracellular Space; In Vitro Techniques; Indoles; KCNQ Potassium Channels; Male; Models, Neurological; Patch-Clamp Techniques; Phenylenediamines; Potassium Channel Blockers; Pyramidal Cells; Pyridines; Rats; Rats, Wistar; Synapses; Tissue Distribution | 2007 |
Determination of N-acetyl retigabine in dog plasma by LC/MS/MS following off-line microElution 96-well solid phase extraction.
Topics: Animals; Calibration; Carbamates; Chromatography, Liquid; Dogs; Female; Male; Phenylenediamines; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2007 |
Phenytoin- and carbamazepine-resistant spontaneous bursting in rat entorhinal cortex is blocked by retigabine in vitro.
Topics: Animals; Anticonvulsants; Carbamates; Carbamazepine; Cell Count; Dose-Response Relationship, Drug; Drug Resistance; Electrophysiology; Entorhinal Cortex; Epilepsy, Temporal Lobe; Evoked Potentials; Excitatory Amino Acid Antagonists; Hippocampus; Ketamine; Male; Nerve Net; Phenylenediamines; Phenytoin; Rats; Rats, Sprague-Dawley | 2007 |
Involvement of KCNQ2 subunits in [3H]dopamine release triggered by depolarization and pre-synaptic muscarinic receptor activation from rat striatal synaptosomes.
Topics: Animals; Blotting, Western; Carbamates; CHO Cells; Cricetinae; Cricetulus; Dopamine; Electrophysiology; Fluorescent Antibody Technique; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Male; Microscopy, Confocal; Muscarinic Agonists; Muscarinic Antagonists; Neostriatum; Nerve Endings; Patch-Clamp Techniques; Phenylenediamines; Rats; Rats, Wistar; Receptors, Muscarinic; Receptors, Presynaptic; Synaptosomes | 2007 |
Modulation of ERG channels by XE991.
Topics: Acetylcholine; Animals; Anthracenes; Carbamates; Cell Line; Chromans; Dose-Response Relationship, Drug; Electrophysiology; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Gene Expression; Indoles; Oocytes; Patch-Clamp Techniques; Phenylenediamines; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Pyridines; Xenopus laevis | 2007 |
Molecular expression and pharmacological identification of a role for K(v)7 channels in murine vascular reactivity.
Topics: Aminopyridines; Animals; Anthracenes; Carbamates; Dose-Response Relationship, Drug; Gene Expression Profiling; Immunohistochemistry; Indoles; Isometric Contraction; KCNQ Potassium Channels; KCNQ1 Potassium Channel; Meclofenamic Acid; Mice; Mice, Inbred BALB C; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phenylenediamines; Potassium Channel Blockers; Potassium Channels; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA | 2007 |
The neuronal KCNQ channel opener retigabine inhibits locomotor activity and reduces forebrain excitatory responses to the psychostimulants cocaine, methylphenidate and phencyclidine.
Topics: Animals; Carbamates; Central Nervous System Stimulants; Cocaine; Dopamine; Excitatory Amino Acid Antagonists; KCNQ Potassium Channels; Male; Membrane Transport Modulators; Methylphenidate; Motor Activity; Phencyclidine; Phenylenediamines; Prosencephalon; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2007 |
K+ M-current regulates the transition to seizures in immature and adult hippocampus.
Topics: Action Potentials; Animals; Anticonvulsants; Carbamates; Disease Models, Animal; Epilepsy, Benign Neonatal; Hippocampus; Humans; Indoles; Male; Mutation; Phenylenediamines; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures | 2007 |
The KCNQ/M-current modulates arterial baroreceptor function at the sensory terminal in rats.
Topics: Animals; Anthracenes; Anticonvulsants; Aorta, Thoracic; Carbamates; KCNQ Potassium Channels; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Male; Membrane Potentials; Neurons, Afferent; Nodose Ganglion; Patch-Clamp Techniques; Phenylenediamines; Pressoreceptors; Presynaptic Terminals; Rats; Rats, Sprague-Dawley | 2008 |
Effect of the new antiepileptic drug retigabine in a rodent model of mania.
Topics: Amphetamine; Animals; Anticonvulsants; Behavior, Animal; Bipolar Disorder; Carbamates; Chlordiazepoxide; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Lamotrigine; Lithium Chloride; Male; Motor Activity; Phenylenediamines; Rats; Rats, Wistar; Triazines | 2008 |
Combinatorial augmentation of voltage-gated KCNQ potassium channels by chemical openers.
Topics: Animals; Binding Sites; Carbamates; CHO Cells; Cricetinae; Cricetulus; Electrophysiology; KCNQ Potassium Channels; Membrane Potentials; Mutagenesis; Organometallic Compounds; Patch-Clamp Techniques; Phenylenediamines; Point Mutation; Pyridines; Sequence Analysis, DNA | 2008 |
Retigabine, the specific KCNQ channel opener, blocks ectopic discharges in axotomized sensory fibres.
Topics: Action Potentials; Animals; Axons; Axotomy; Carbamates; Female; KCNQ Potassium Channels; Male; Mice; Neural Inhibition; Phenylenediamines; Sensory Receptor Cells | 2008 |
Retigabine reduces the excitability of unmyelinated peripheral human axons.
Topics: Action Potentials; Aged; Aged, 80 and over; Anthracenes; Anticonvulsants; Axons; Carbamates; Electrophysiology; Female; Humans; In Vitro Techniques; Male; Middle Aged; Nerve Fibers, Unmyelinated; Patch-Clamp Techniques; Peripheral Nerves; Phenylenediamines; Sural Nerve; Tachyphylaxis | 2008 |
Antiepileptogenic and antiictogenic effects of retigabine under conditions of rapid kindling: an ontogenic study.
Topics: Aging; Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Carbamates; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Electroencephalography; Epilepsy; Hippocampus; Kindling, Neurologic; Male; Motor Activity; Phenylenediamines; Rats; Rats, Wistar; Time Factors | 2008 |
Bimodal effects of the Kv7 channel activator retigabine on vascular K+ currents.
Topics: Aminopyridines; Animals; Anthracenes; Carbamates; Dose-Response Relationship, Drug; In Vitro Techniques; KCNQ Potassium Channels; KCNQ1 Potassium Channel; Membrane Potentials; Mice; Mice, Inbred BALB C; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phenylenediamines; Portal Vein; Potassium; Potassium Channel Blockers; Recombinant Proteins; RNA, Messenger; Time Factors; Vasoconstriction; Vasodilator Agents; Xenopus laevis | 2008 |
KCNQ-encoded channels regulate Na+ transport across H441 lung epithelial cells.
Topics: Anthracenes; Anticonvulsants; Brain; Carbamates; Cell Line; Epithelial Cells; Humans; KCNQ Potassium Channels; Lung; Myocardium; Peptides; Phenylenediamines; Potassium Channel Blockers; Protein Isoforms; Sodium | 2009 |
Expression and function of K(v)7 channels in murine myometrium throughout oestrous cycle.
Topics: Animals; Anthracenes; Carbamates; Chromans; Estrous Cycle; Female; KCNQ1 Potassium Channel; Mice; Mice, Inbred C57BL; Myometrium; Phenylenediamines; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Sulfonamides; Uterine Contraction | 2009 |
Isobolographic characterization of interactions of retigabine with carbamazepine, lamotrigine, and valproate in the mouse maximal electroshock-induced seizure model.
Topics: Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Brain; Carbamates; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Electroshock; Injections, Intraperitoneal; Lamotrigine; Male; Memory; Mice; Motor Activity; Muscle Strength; Phenylenediamines; Psychomotor Performance; Seizures; Triazines; Valproic Acid | 2009 |
Low expression of Kv7/M channels facilitates intrinsic and network bursting in the developing rat hippocampus.
Topics: Action Potentials; Animals; Animals, Newborn; Carbamates; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Indoles; KCNQ2 Potassium Channel; Kinetics; Nerve Net; Phenylenediamines; Potassium Channel Blockers; Pyramidal Cells; Pyridines; Rats; Rats, Wistar; Sodium Potassium Chloride Symporter Inhibitors; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; Synaptic Transmission | 2008 |
Deal watch: GSK acquires rights to Valeant's anti-epileptic drug.
Topics: Anticonvulsants; Carbamates; Clinical Trials as Topic; Commerce; Drug Industry; Epilepsy; Legislation, Drug; Phenylenediamines | 2008 |
Ion channel targets - select biosciences' fourth annual conference.
Topics: Anticonvulsants; Autoimmune Diseases; Carbamates; Drug Evaluation, Preclinical; Humans; Ion Channel Gating; Ion Channels; Phenylenediamines | 2008 |
Refinement of the binding site and mode of action of the anticonvulsant Retigabine on KCNQ K+ channels.
Topics: Action Potentials; Animals; Anticonvulsants; Binding Sites; Carbamates; KCNQ3 Potassium Channel; Leucine; Membrane Potentials; Models, Molecular; Phenylenediamines; Tryptophan; Xenopus laevis | 2009 |
Antipsychotic-like effect of retigabine [N-(2-Amino-4-(fluorobenzylamino)-phenyl)carbamic acid ester], a KCNQ potassium channel opener, via modulation of mesolimbic dopaminergic neurotransmission.
Topics: Animals; Anthracenes; Antipsychotic Agents; Carbamates; Dopamine; KCNQ Potassium Channels; Limbic System; Male; Microdialysis; Nucleus Accumbens; Phenylenediamines; Rats; Rats, Wistar; Synaptic Transmission | 2009 |
Effects of neuronal Kv7 potassium channel activators on hyperactivity in a rodent model of mania.
Topics: Amphetamine; Animals; Anticonvulsants; Antimanic Agents; Benzamides; Bipolar Disorder; Carbamates; Central Nervous System Stimulants; Chlordiazepoxide; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Hyperkinesis; Indoles; Injections, Intraperitoneal; KCNQ Potassium Channels; Lamotrigine; Lithium Compounds; Male; Mice; Mice, Inbred C57BL; Motor Activity; Phenylenediamines; Pyridines; Triazines | 2009 |
Activity-dependent depression of the spike after-depolarization generates long-lasting intrinsic plasticity in hippocampal CA3 pyramidal neurons.
Topics: Action Potentials; Animals; Anthracenes; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Signaling; Carbamates; Cardiovascular Agents; Chelating Agents; Egtazic Acid; Hippocampus; In Vitro Techniques; KCNQ Potassium Channels; Male; Membrane Potentials; Neuronal Plasticity; Patch-Clamp Techniques; Phenylenediamines; Pyramidal Cells; Pyrimidines; Rats; Rats, Wistar | 2009 |
Inhibition of transmitter release from rat sympathetic neurons via presynaptic M(1) muscarinic acetylcholine receptors.
Topics: Acetylcholine; Action Potentials; Adrenergic Fibers; Animals; Animals, Newborn; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Carbamates; Cells, Cultured; Diamines; Dose-Response Relationship, Drug; Electric Stimulation; KCNQ Potassium Channels; Muscarinic Agonists; Muscarinic Antagonists; Neural Inhibition; Norepinephrine; omega-Conotoxin GVIA; Oxotremorine; Pertussis Toxin; Phenylenediamines; Pirenzepine; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1; Receptors, Presynaptic; Superior Cervical Ganglion; Synaptic Transmission; Time Factors; Type C Phospholipases | 2009 |
Molecular and functional characterization of Kv7 K+ channel in murine gastrointestinal smooth muscles.
Topics: Animals; Anthracenes; Blotting, Western; Carbamates; Chromans; Colon; Gastrointestinal Tract; Immunohistochemistry; Indoles; KCNQ Potassium Channels; KCNQ1 Potassium Channel; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Myography; Phenylenediamines; Potassium Channel Blockers; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides | 2009 |
An osmosensitive voltage-gated K+ current in rat supraoptic neurons.
Topics: Action Potentials; Animals; Anticonvulsants; Barium; Carbamates; Ion Channel Gating; KCNQ2 Potassium Channel; Male; Neurons; Organ Culture Techniques; Osmolar Concentration; Patch-Clamp Techniques; Phenylenediamines; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Rats; Rats, Long-Evans; Supraoptic Nucleus; Water-Electrolyte Balance | 2009 |
Effects of XE991, retigabine, losigamone and ZD7288 on kainate-induced theta-like and gamma network oscillations in the rat hippocampus in vitro.
Topics: Animals; Anthracenes; Anticonvulsants; Biological Clocks; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Carbamates; Electrophysiology; Excitatory Amino Acid Agonists; Furans; Kainic Acid; Membrane Potentials; Nerve Net; Neurons; Periodicity; Phenylenediamines; Pyrimidines; Rats; Rats, Wistar | 2009 |
The KCNQ2/3 selective channel opener ICA-27243 binds to a novel voltage-sensor domain site.
Topics: Amino Acid Sequence; Animals; Anticonvulsants; Benzamides; Binding Sites; Carbamates; CHO Cells; Cricetinae; Cricetulus; Humans; KCNQ Potassium Channels; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Membrane Potentials; Membrane Transport Modulators; Molecular Sequence Data; Mutation; Phenylenediamines; Pyridines; Sequence Alignment; Tryptophan | 2009 |
Antimanic efficacy of retigabine in a proposed mouse model of bipolar disorder.
Topics: Amphetamine; Analysis of Variance; Animals; Anticonvulsants; Antimanic Agents; Behavior, Animal; Bipolar Disorder; Carbamates; Disease Models, Animal; Dose-Response Relationship, Drug; Food Preferences; Lithium Chloride; Male; Mice; Motor Activity; Phenylenediamines; Saccharin; Treatment Outcome | 2010 |
The acrylamide (S)-2 as a positive and negative modulator of Kv7 channels expressed in Xenopus laevis oocytes.
Topics: Acrylamide; Acrylamides; Animals; Binding Sites; Carbamates; Humans; Ion Channel Gating; KCNQ Potassium Channels; Kinetics; Membrane Potentials; Mutant Proteins; Oocytes; Oxazines; Phenylenediamines; Tryptophan; Xenopus laevis | 2009 |
Expression, localization, and pharmacological role of Kv7 potassium channels in skeletal muscle proliferation, differentiation, and survival after myotoxic insults.
Topics: Adult; Animals; Anthracenes; Carbamates; Cell Differentiation; Cell Line; Cell Proliferation; Cell Survival; Cricetinae; Cricetulus; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; KCNQ Potassium Channels; KCNQ1 Potassium Channel; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Lovastatin; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Myoblasts, Skeletal; Phenylenediamines; Protein Subunits; RNA, Messenger; Up-Regulation | 2010 |
The contribution of Kv7 channels to pregnant mouse and human myometrial contractility.
Topics: Aminopyridines; Animals; Anthracenes; Anticonvulsants; Carbamates; Female; Gene Expression; Gestational Age; Humans; KCNQ Potassium Channels; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Myometrium; Phenylenediamines; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Pregnancy; Protein Isoforms; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Uterine Contraction | 2011 |
Muscarinic receptor type 1 (M1) stimulation, probably through KCNQ/Kv7 channel closure, increases spontaneous GABA release at the dendrodendritic synapse in the mouse accessory olfactory bulb.
Topics: Alkaloids; Animals; Anticonvulsants; Calcium; Calcium Channel Blockers; Calcium Channels, R-Type; Carbachol; Carbamates; Cholinergic Agonists; Dendrites; Diclofenac; Excitatory Amino Acid Antagonists; Furans; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Ion Channel Gating; KCNQ Potassium Channels; Mice; Mice, Inbred BALB C; Muscarinic Antagonists; Naphthalenes; Nimodipine; Olfactory Bulb; Patch-Clamp Techniques; Phenylenediamines; Piperidines; Pirenzepine; Potassium Channel Blockers; Receptor, Muscarinic M1; Receptors, Glutamate; Synapses | 2010 |
Functional effects of the KCNQ modulators retigabine and XE991 in the rat urinary bladder.
Topics: Animals; Anthracenes; Anticonvulsants; Carbachol; Carbamates; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; In Vitro Techniques; KCNQ Potassium Channels; Muscle Contraction; Phenylenediamines; Potassium Channel Blockers; Potassium Chloride; Rats; Rats, Sprague-Dawley; Urinary Bladder | 2010 |
Systemic peripheral artery relaxation by KCNQ channel openers and hydrogen sulfide.
Topics: Adipose Tissue; Animals; Anthracenes; Aorta; Arteries; Carbamates; Hydrogen Sulfide; In Vitro Techniques; Isometric Contraction; KCNQ Potassium Channels; Male; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Paracrine Communication; Phenylenediamines; Rats; Rats, Sprague-Dawley; Vasodilation | 2010 |
Evaluation of development-specific targets for antiepileptogenic therapy using rapid kindling.
Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Bumetanide; Carbamates; Disease Models, Animal; Fructose; Hippocampus; Kindling, Neurologic; Phenylenediamines; Rats; Topiramate | 2010 |
Differential effects of ICA-27243 on cloned K(V)7 channels.
Topics: Animals; Benzamides; Binding Sites; Carbamates; Cells, Cultured; CHO Cells; Cloning, Molecular; Cricetinae; Cricetulus; Female; KCNQ Potassium Channels; KCNQ2 Potassium Channel; Membrane Potentials; Oocytes; Phenylenediamines; Pyridines; Rubidium Radioisotopes; Xenopus laevis | 2010 |
Activation of voltage-gated KCNQ/Kv7 channels by anticonvulsant retigabine attenuates mechanical allodynia of inflammatory temporomandibular joint in rats.
Topics: Analgesia; Animals; Anthracenes; Anticonvulsants; Carbamates; Feeding Behavior; Freund's Adjuvant; Hyperalgesia; Inflammation; Injections, Intraventricular; Ion Channel Gating; KCNQ Potassium Channels; Male; Phenylenediamines; Rats; Rats, Sprague-Dawley; Temporomandibular Joint | 2010 |
Kv7 (KCNQ) channel openers induce hypothermia in the mouse.
Topics: Animals; Anthracenes; Anticonvulsants; Benzamides; Body Temperature Regulation; Carbamates; Female; Hypothermia; Indoles; KCNQ Potassium Channels; Mice; Phenylenediamines; Protein Isoforms; Pyridines | 2011 |
Functional role of M-type (KCNQ) K⁺ channels in adrenergic control of cardiomyocyte contraction rate by sympathetic neurons.
Topics: Animals; Carbamates; Cardiotonic Agents; Cells, Cultured; Coculture Techniques; Ganglionic Stimulants; Heart; Heart Rate; Isoproterenol; KCNQ Potassium Channels; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Contraction; Myocytes, Cardiac; Nicotine; Phenylenediamines; Purinergic P2Y Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptor, Bradykinin B2; Sympathetic Nervous System | 2011 |
Characteristics and molecular basis of celecoxib modulation on K(v)7 potassium channels.
Topics: Animals; Carbamates; Celecoxib; Cells, Cultured; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; HEK293 Cells; Humans; KCNQ Potassium Channels; Neurons; Phenylenediamines; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides; Superior Cervical Ganglion; Transfection | 2011 |
The pharmacological effect of positive KCNQ (Kv7) modulators on dopamine release from striatal slices.
Topics: Animals; Anthracenes; Anticonvulsants; Benzamides; Carbamates; Dopamine; Dopamine Antagonists; In Vitro Techniques; Indoles; Inhibitory Concentration 50; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Male; Mesencephalon; Neostriatum; Neurons; Nonlinear Dynamics; Phenylenediamines; Potassium Channel Blockers; Potassium Chloride; Pyridines; Rats; Rats, Wistar; Regression Analysis | 2011 |
Expression and function of KCNQ channels in larval zebrafish.
Topics: Action Potentials; Analysis of Variance; Animals; Anthracenes; Anticonvulsants; Brain; Carbamates; Dose-Response Relationship, Drug; Electrophysiology; Gene Expression Regulation, Developmental; Indoles; KCNQ Potassium Channels; Larva; Locomotion; Morpholinos; Phenylenediamines; Potassium Channel Blockers; Pyridines; RNA, Messenger; Swimming; Zebrafish | 2012 |
KCNQ2/3 openers show differential selectivity and site of action across multiple KCNQ channels.
Topics: Carbamates; HEK293 Cells; Humans; Ion Channel Gating; KCNQ Potassium Channels; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Mutation; Phenylenediamines; Thallium | 2011 |
KV7 channels regulate muscle tone and nonadrenergic noncholinergic relaxation of the rat gastric fundus.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Anticonvulsants; Carbamates; Female; Gastric Fundus; KCNQ Potassium Channels; Male; Muscle Relaxation; Muscle Tonus; Phenylenediamines; Rats; Rats, Wistar | 2011 |
Downregulation of Kv7.4 channel activity in primary and secondary hypertension.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Blood Pressure; Carbamates; Down-Regulation; Hypertension; In Vitro Techniques; Indoles; KCNQ Potassium Channels; Male; Membrane Potentials; Mesenteric Arteries; Mice; Phenylenediamines; Rats; Rats, Inbred SHR; Rats, Wistar; Vasoconstrictor Agents | 2011 |
Kv 7 positive modulators reduce detrusor overactivity and increase bladder capacity in rats.
Topics: Animals; Anthracenes; Capsaicin; Carbamates; Female; KCNQ Potassium Channels; Phenylenediamines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Urinary Bladder; Urinary Bladder, Overactive | 2012 |
Drosophila KCNQ channel displays evolutionarily conserved electrophysiology and pharmacology with mammalian KCNQ channels.
Topics: Animals; Anthracenes; Carbamates; Cell Line; Chromans; Drosophila; Drosophila Proteins; Electrophysiology; Humans; Indoles; KCNQ Potassium Channels; KCNQ1 Potassium Channel; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Organometallic Compounds; Patch-Clamp Techniques; Phenylenediamines; Pyridines; Sulfonamides | 2011 |
Neuroprotective effects of Kv7 channel agonist, retigabine, for cisplatin-induced peripheral neuropathy.
Topics: Action Potentials; Animals; Carbamates; Cisplatin; Disease Models, Animal; Drug Interactions; Injections, Intraperitoneal; Male; Mice; Neural Conduction; Neuroprotective Agents; Peripheral Nervous System Diseases; Phenylenediamines; Potassium Channel Blockers; Time Factors | 2011 |
Restoration of ion channel function in deafness-causing KCNQ4 mutants by synthetic channel openers.
Topics: Animals; Carbamates; CHO Cells; Cricetinae; Cricetulus; Hair Cells, Auditory, Outer; Hearing Loss, Sensorineural; KCNQ Potassium Channels; Models, Molecular; Mutant Proteins; Organometallic Compounds; Patch-Clamp Techniques; Phenylenediamines; Pyridines; Rats; Rats, Wistar; Recombinant Fusion Proteins | 2012 |
Ezogabine (retigabine).
Topics: Animals; Anticonvulsants; Carbamates; Epilepsies, Partial; Humans; Phenylenediamines; Randomized Controlled Trials as Topic | 2011 |
Kv7 potassium channels in airway smooth muscle cells: signal transduction intermediates and pharmacological targets for bronchodilator therapy.
Topics: Aminopyridines; Animals; Anthracenes; Bronchoconstriction; Bronchodilator Agents; Calcium Channel Blockers; Carbamates; Celecoxib; Guinea Pigs; Histamine; Humans; KCNQ Potassium Channels; Male; Methacholine Chloride; Myocytes, Smooth Muscle; Patch-Clamp Techniques; Phenylenediamines; Pyrazoles; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sulfonamides; Verapamil | 2012 |
Visceral hyperalgesia induced by forebrain-specific suppression of native Kv7/KCNQ/M-current in mice.
Topics: Animals; Anthracenes; Capsaicin; Carbamates; Hyperalgesia; KCNQ2 Potassium Channel; Magnesium Sulfate; Mice; Mice, Transgenic; Phenylenediamines; Prosencephalon; Proto-Oncogene Proteins c-fos; Somatosensory Cortex; Visceral Pain | 2011 |
Retigabine, a K(V)7 (KCNQ) potassium channel opener, attenuates L-DOPA-induced dyskinesias in 6-OHDA-lesioned rats.
Topics: Amantadine; Aminopyridines; Animals; Anticonvulsants; Antiparkinson Agents; Behavior, Animal; Carbamates; Dyskinesia, Drug-Induced; Female; Motor Activity; Oxidopamine; Phenylenediamines; Rats; Rats, Sprague-Dawley; Stereotyped Behavior | 2012 |
A potassium channel opener for neuropathy, motor neuron disease and beyond.
Topics: Animals; Carbamates; Cisplatin; Male; Neuroprotective Agents; Peripheral Nervous System Diseases; Phenylenediamines; Potassium Channel Blockers | 2011 |
Effects of KCNQ channel modulators on the M-type potassium current in primate retinal pigment epithelium.
Topics: Animals; Carbamates; Cells, Cultured; Chromans; Ethylmaleimide; Indoles; KCNQ Potassium Channels; Macaca fascicularis; Macaca mulatta; Neurons; Organometallic Compounds; Patch-Clamp Techniques; Phenylenediamines; Potassium; Potassium Channel Blockers; Protein Subunits; Pyridines; Retinal Pigment Epithelium; Sulfonamides; Tetraethylammonium | 2012 |
M channel enhancers and physiological M channel block.
Topics: Aminopyridines; Animals; Bradykinin; Calcium; Carbamates; CHO Cells; Cricetinae; Cricetulus; Ganglia, Spinal; Hydrogen Peroxide; Inflammation; KCNQ Potassium Channels; Organometallic Compounds; Pain; Phenylenediamines; Phosphatidylinositol 4,5-Diphosphate; Pyridines; Rats; Rats, Wistar; Sensory Receptor Cells; Type C Phospholipases | 2012 |
Annual drug update: 2011 in review.
Topics: Abatacept; Aminoglycosides; Carbamates; Drug Approval; Fentanyl; Fidaxomicin; Humans; Immunoconjugates; Indans; Linagliptin; Phenylenediamines; Proline; Purines; Quinazolines; Quinolones; United States; United States Food and Drug Administration | 2012 |
The spectrum of anticonvulsant efficacy of retigabine (ezogabine) in animal models: implications for clinical use.
Topics: Animals; Anticonvulsants; Carbamates; Disease Models, Animal; Drug Synergism; Epilepsy; Humans; KCNQ Potassium Channels; Neurons; Phenylenediamines; Treatment Outcome | 2012 |
[Neurology].
Topics: Antibodies, Monoclonal; Anticonvulsants; Atrial Fibrillation; Carbamates; Chronic Disease; Deep Brain Stimulation; Dopamine Agonists; Epilepsy; Fingolimod Hydrochloride; Genetic Therapy; Humans; Immunosuppressive Agents; Ischemic Attack, Transient; Multiple Sclerosis; Muscular Diseases; Neurology; Parkinson Disease; Phenylenediamines; Polyneuropathies; Propylene Glycols; Sphingosine; Stroke; Treatment Outcome; Valproic Acid | 2012 |
K(v) 7 (KCNQ) channel openers normalize central 2-deoxyglucose uptake in a mouse model of mania and increase prefrontal cortical and hippocampal serine-9 phosphorylation levels of GSK3β.
Topics: Animals; Antimanic Agents; Autoradiography; Benzamides; Bipolar Disorder; Carbamates; Central Nervous System Stimulants; Chlordiazepoxide; Deoxyglucose; Dextroamphetamine; Dose-Response Relationship, Drug; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; Hypnotics and Sedatives; KCNQ Potassium Channels; Male; Mice; Mice, Inbred C57BL; Phenylenediamines; Phosphorylation; Prefrontal Cortex; Pyridines; Serine | 2012 |
Retigabine: fewer drug interactions.
Topics: Anticonvulsants; Carbamates; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Phenylenediamines; Randomized Controlled Trials as Topic | 2012 |
Anticonvulsant effect of retigabine during postnatal development in rats.
Topics: Aging; Animals; Animals, Newborn; Anticonvulsants; Carbamates; Convulsants; Dose-Response Relationship, Drug; Epilepsy; Female; Injections, Subcutaneous; Kindling, Neurologic; Pentylenetetrazole; Phenylenediamines; Pregnancy; Rats; Rats, Sprague-Dawley; Seizures | 2012 |
Treating seizures. Achievable control.
Topics: Anticonvulsants; Carbamates; Electric Stimulation Therapy; Humans; Neurosurgical Procedures; Phenylenediamines; Risk Factors; Seizures | 2012 |
Ezogabine (Potiga) for epilepsy.
Topics: Administration, Oral; Adult; Anticonvulsants; Carbamates; Drug Interactions; Epilepsies, Partial; Humans; Phenylenediamines | 2012 |
Identification and characterization of four process-related impurities in retigabine.
Topics: Anticonvulsants; Carbamates; Chromatography, High Pressure Liquid; Drug Contamination; Magnetic Resonance Spectroscopy; Phenylenediamines; Spectrophotometry, Infrared; Spectroscopy, Fourier Transform Infrared; Tandem Mass Spectrometry | 2012 |
Development and validation of a medium-throughput electrophysiological assay for KCNQ2/3 channel openers using QPatch HT.
Topics: Carbamates; Electrophysiological Phenomena; HEK293 Cells; High-Throughput Screening Assays; Humans; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Membrane Transport Modulators; Patch-Clamp Techniques; Phenylenediamines | 2013 |
Vascular KCNQ (Kv7) potassium channels as common signaling intermediates and therapeutic targets in cerebral vasospasm.
Topics: Animals; Anthracenes; Arginine Vasopressin; Basilar Artery; Carbamates; Celecoxib; Disease Models, Animal; Endothelin-1; KCNQ Potassium Channels; Male; Membrane Transport Modulators; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Myography; Patch-Clamp Techniques; Phenylenediamines; Potassium Channel Blockers; Pyrazoles; Rats; Rats, Sprague-Dawley; Serotonin; Signal Transduction; Subarachnoid Hemorrhage; Sulfonamides; Time Factors; Vasoconstriction; Vasoconstrictor Agents; Vasospasm, Intracranial | 2013 |
KCNQ channels determine serotonergic modulation of ventral surface chemoreceptors and respiratory drive.
Topics: Anesthesia; Animals; Animals, Newborn; Brain Stem; Carbamates; Carbon Dioxide; Chemoreceptor Cells; Drive; Electrophysiological Phenomena; In Vitro Techniques; KCNQ Potassium Channels; Male; Phenylenediamines; Phrenic Nerve; Rats; Respiratory Mechanics; Serotonin; Small-Conductance Calcium-Activated Potassium Channels; Substance P; Thyrotropin-Releasing Hormone | 2012 |
The new KCNQ2 activator 4-Chlor-N-(6-chlor-pyridin-3-yl)-benzamid displays anticonvulsant potential.
Topics: Amygdala; Animals; Anticonvulsants; Benzamides; CA1 Region, Hippocampal; Carbamates; CHO Cells; Cricetinae; Cricetulus; Female; In Vitro Techniques; KCNQ2 Potassium Channel; Oocytes; Phenylenediamines; Pyramidal Cells; Pyridines; Rats; Rats, Wistar; Synaptic Transmission; Xenopus laevis | 2013 |
Specification of skeletal muscle differentiation by repressor element-1 silencing transcription factor (REST)-regulated Kv7.4 potassium channels.
Topics: 5' Untranslated Regions; Animals; Binding Sites; Carbamates; Cell Differentiation; Cell Line; Gene Knockdown Techniques; KCNQ Potassium Channels; Membrane Transport Modulators; Mice; Muscle Development; Muscle Fibers, Skeletal; Muscle, Skeletal; Phenylenediamines; Protein Binding; Repressor Proteins; RNA, Small Interfering; Transcription Initiation Site; Transcription, Genetic; Transcriptional Activation | 2013 |
Hippocalcin and KCNQ channels contribute to the kinetics of the slow afterhyperpolarization.
Topics: Animals; CA3 Region, Hippocampal; Calcium; Carbamates; Female; Gene Knockout Techniques; Hippocalcin; KCNQ Potassium Channels; Kinetics; Male; Membrane Potentials; Mice; Neurons; Phenylenediamines | 2012 |
New drugs 2013, Part I.
Topics: Aminophenols; Anilides; Antibodies, Monoclonal, Humanized; Axitinib; Benzodiazepines; Carbamates; Clobazam; Diterpenes; Drug Approval; gamma-Glutamyl Hydrolase; Glucosylceramidase; Humans; Imidazoles; Indans; Indazoles; Peptides; Phenylenediamines; Prostaglandins F; Pyridines; Quinolones | 2013 |
Suppression of KCNQ/M (Kv7) potassium channels in dorsal root ganglion neurons contributes to the development of bone cancer pain in a rat model.
Topics: Animals; Anthracenes; Bone Neoplasms; Carbamates; Carcinoma; Down-Regulation; Female; Ganglia, Spinal; Hot Temperature; Hyperalgesia; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Mammary Neoplasms, Experimental; Neoplasm Transplantation; Nociception; Pain; Patch-Clamp Techniques; Phenylenediamines; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Stress, Mechanical; Synaptic Transmission; Tibia | 2013 |
Retigabine as add-on treatment of refractory epilepsy--a cost-utility study in a Swedish setting.
Topics: Acetamides; Adult; Anticonvulsants; Carbamates; Cost-Benefit Analysis; Drug Therapy, Combination; Epilepsies, Partial; Health Care Costs; Humans; Lacosamide; Phenylenediamines; Quality-Adjusted Life Years; Sensitivity and Specificity; Sweden | 2013 |
Genotype-phenotype correlations in neonatal epilepsies caused by mutations in the voltage sensor of K(v)7.2 potassium channel subunits.
Topics: Amino Acid Substitution; Animals; Anticonvulsants; Carbamates; CHO Cells; Cricetinae; Cricetulus; Epilepsy, Benign Neonatal; Genotype; Humans; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Models, Molecular; Mutation, Missense; Phenotype; Phenylenediamines; Pyramidal Cells; Structural Homology, Protein | 2013 |
Triple cysteine module within M-type K+ channels mediates reciprocal channel modulation by nitric oxide and reactive oxygen species.
Topics: Action Potentials; Aniline Compounds; Animals; Animals, Newborn; Anthracenes; Benzoates; Biotin; Calcitonin Gene-Related Peptide; Carbamates; Cells, Cultured; Cysteine; Enzyme Inhibitors; Female; Humans; Imidazoles; KCNQ Potassium Channels; Male; Membrane Transport Modulators; Models, Molecular; Mutation; Neurons; Nitric Oxide; Nitric Oxide Donors; Patch-Clamp Techniques; Phenylenediamines; Potassium Channel Blockers; Rats; Reactive Oxygen Species; S-Nitroso-N-Acetylpenicillamine; Transfection; Trigeminal Ganglion | 2013 |
Ezogabine (KCNQ2/3 channel opener) prevents delayed activation of meningeal nociceptors if given before but not after the occurrence of cortical spreading depression.
Topics: Action Potentials; Animals; Anticonvulsants; Carbamates; Cortical Spreading Depression; Drug Administration Schedule; Male; Nociceptors; Pain Measurement; Phenylenediamines; Physical Stimulation; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Time Factors; Trigeminal Ganglion | 2013 |
M-channels modulate network excitatory activity induced by 4-aminopyridine in immature rat substantia gelatinosa in vitro.
Topics: 4-Aminopyridine; Action Potentials; Aminopyridines; Analgesics; Animals; Animals, Newborn; Anthracenes; Biological Clocks; Biophysical Phenomena; Carbamates; Dose-Response Relationship, Drug; Drug Interactions; Female; In Vitro Techniques; Indoles; Male; Membrane Transport Modulators; Nerve Net; Neurons; Phenylenediamines; Potassium Channel Blockers; Pyridines; Rats; Rats, Wistar; Substantia Gelatinosa | 2013 |
Cardiovascular responses to retigabine in conscious rats--under normotensive and hypertensive conditions.
Topics: Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Agonists; Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Carbamates; CHO Cells; Coronary Circulation; Cricetulus; Dose-Response Relationship, Drug; Humans; Hypertension; KCNQ Potassium Channels; KCNQ2 Potassium Channel; Male; Membrane Transport Modulators; Phenylenediamines; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta-2; Recombinant Proteins; Vasodilation | 2013 |
Kv7/M-type potassium channels in rat skin keratinocytes.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Anthracenes; Calcium; Carbamates; Cells, Cultured; Cymenes; KCNQ2 Potassium Channel; Keratinocytes; Monoterpenes; Phenylenediamines; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Skin; TRPV Cation Channels | 2013 |
Phosphatidylinositol 4,5-bisphosphate alters pharmacological selectivity for epilepsy-causing KCNQ potassium channels.
Topics: Animals; Anticonvulsants; Carbamates; CHO Cells; Cricetinae; Cricetulus; Epilepsy; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Keratolytic Agents; Mice; Mutation; Nerve Tissue Proteins; Neurons; Organometallic Compounds; Phenylenediamines; Phosphatidylinositol 4,5-Diphosphate; Pyridines; Signal Transduction | 2013 |
Migraine and epilepsy: progress towards preemptive therapy.
Topics: Animals; Anticonvulsants; Carbamates; Cortical Spreading Depression; Male; Nociceptors; Phenylenediamines; Trigeminal Ganglion | 2013 |
Ring chromosome 20: a pediatric potassium channelopathy responsive to treatment with ezogabine.
Topics: Anticonvulsants; Carbamates; Channelopathies; Child; Chromosomes, Human, Pair 20; Female; Humans; Phenylenediamines; Potassium Channels; Ring Chromosomes | 2013 |
Discovery of a retigabine derivative that inhibits KCNQ2 potassium channels.
Topics: Animals; Anthracenes; Anticonvulsants; Carbamates; CHO Cells; Cricetinae; Cricetulus; Drug Design; Inhibitory Concentration 50; KCNQ2 Potassium Channel; Patch-Clamp Techniques; Phenylenediamines; Potassium Channel Blockers; Structure-Activity Relationship | 2013 |
Effects of KCNQ2 gene truncation on M-type Kv7 potassium currents.
Topics: Action Potentials; Animals; Carbamates; Cells, Cultured; Female; Gene Expression; Humans; KCNQ2 Potassium Channel; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Phenylenediamines; Potassium Channel Blockers; RNA, Messenger; Superior Cervical Ganglion; Tetraethylammonium | 2013 |
The preclinical discovery and development of ezogabine for the treatment of epilepsy.
Topics: Animals; Anticonvulsants; Carbamates; Drug Discovery; Epilepsy; Humans; Phenylenediamines; Product Surveillance, Postmarketing | 2013 |
Molecular expression and pharmacological evidence for a functional role of kv7 channel subtypes in Guinea pig urinary bladder smooth muscle.
Topics: Acetylcholine; Animals; Anthracenes; Benzodiazepines; Blotting, Western; Carbamates; Cells, Cultured; Electric Stimulation; Guinea Pigs; Immunoenzyme Techniques; KCNQ Potassium Channels; Male; Membrane Transport Modulators; Muscle Contraction; Muscle, Smooth; Patch-Clamp Techniques; Phenylenediamines; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Urinary Bladder | 2013 |
Expression and motor functional roles of voltage-dependent type 7 K(+) channels in the human taenia coli.
Topics: Aged; Aged, 80 and over; Aminopyridines; Anthracenes; Carbamates; Colon; Gastrointestinal Motility; Gene Expression Regulation; Humans; In Vitro Techniques; KCNQ Potassium Channels; Middle Aged; Phenylenediamines; RNA, Messenger | 2013 |
Ezogabine (Potiga) toxicity.
Topics: Adult; Anticonvulsants; Carbamates; Drug Labeling; Epilepsies, Partial; Humans; Phenylenediamines; United States; United States Food and Drug Administration | 2013 |
Dominant-negative effects of KCNQ2 mutations are associated with epileptic encephalopathy.
Topics: Animals; Carbamates; Epilepsy, Benign Neonatal; Genetic Predisposition to Disease; Humans; KCNQ2 Potassium Channel; Membrane Potentials; Mutation, Missense; Oocytes; Phenylenediamines; Potassium Channels, Voltage-Gated; Xenopus | 2014 |
Complementary functions of SK and Kv7/M potassium channels in excitability control and synaptic integration in rat hippocampal dentate granule cells.
Topics: Action Potentials; Animals; Benzimidazoles; Carbamates; Excitatory Postsynaptic Potentials; Hippocampus; KCNQ Potassium Channels; Male; Membrane Potentials; Membrane Transport Modulators; Neurons; Phenylenediamines; Rats; Rats, Wistar; Small-Conductance Calcium-Activated Potassium Channels; Synapses | 2014 |
Retigabine: blue skin discoloration and retinal pigment abnormalities.
Topics: Anticonvulsants; Carbamates; Humans; Phenylenediamines; Pigmentation Disorders; Retinal Pigment Epithelium | 2013 |
KCNQ (Kv7) potassium channel activators as bronchodilators: combination with a β2-adrenergic agonist enhances relaxation of rat airways.
Topics: Acetylcholine; Adrenergic beta-2 Receptor Agonists; Animals; Anthracenes; Asthma; Bronchi; Bronchoconstriction; Bronchoconstrictor Agents; Bronchodilator Agents; Carbamates; Ethanolamines; Formoterol Fumarate; KCNQ Potassium Channels; Keratolytic Agents; Male; Membrane Transport Modulators; Methacholine Chloride; Myocytes, Smooth Muscle; Organometallic Compounds; Patch-Clamp Techniques; Phenylenediamines; Potassium Channel Blockers; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Sulfonamides | 2014 |
Identification, characterization, synthesis and HPLC quantification of new process-related impurities and degradation products in retigabine.
Topics: Carbamates; Chromatography, High Pressure Liquid; Drug Contamination; Drug Stability; Limit of Detection; Phenylenediamines; Reference Standards | 2014 |
Activation of peripheral KCNQ channels attenuates inflammatory pain.
Topics: Animals; Anthracenes; Anticonvulsants; Benzamides; Carbamates; Disease Models, Animal; Electric Stimulation; Exploratory Behavior; Formaldehyde; Freund's Adjuvant; Functional Laterality; Hyperalgesia; Inflammation; KCNQ Potassium Channels; Motor Skills Disorders; Pain; Pain Measurement; Pain Threshold; Phenylenediamines; Potassium Channel Blockers; Pyridines; Rats | 2014 |
Enhanced in vitro CA1 network activity in a sodium channel β1(C121W) subunit model of genetic epilepsy.
Topics: Action Potentials; Animals; Anticonvulsants; CA1 Region, Hippocampal; Carbamates; Carbamazepine; Disease Models, Animal; Epilepsy; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Net; Organ Culture Techniques; Phenylenediamines; Up-Regulation; Voltage-Gated Sodium Channel beta-1 Subunit | 2014 |
Ezogabine treatment of childhood absence epilepsy.
Topics: Anticonvulsants; Carbamates; Drug Interactions; Electroencephalography; Epilepsy, Absence; Female; Humans; Isoxazoles; Lamotrigine; Middle Aged; Phenylenediamines; Treatment Outcome; Triazines; Zonisamide | 2014 |
Adjunctive use of ezogabine/retigabine with either traditional sodium channel blocking antiepileptic drugs (AEDs) or AEDs with other mechanisms of action: Evaluation of efficacy and tolerability.
Topics: Adult; Anticonvulsants; Carbamates; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Phenylenediamines; Randomized Controlled Trials as Topic; Sodium Channel Blockers; Treatment Outcome | 2014 |
The Kv7 potassium channel activator retigabine decreases alcohol consumption in rats.
Topics: Alcohol Drinking; Animals; Carbamates; Choice Behavior; Drinking Behavior; Male; Membrane Transport Modulators; Phenylenediamines; Potassium Channels; Rats; Rats, Long-Evans | 2014 |
Diabetes attenuates urothelial modulation of detrusor contractility and spontaneous activity.
Topics: Animals; Anthracenes; Carbachol; Carbamates; Cholinergic Agonists; Diabetes Mellitus, Experimental; KCNQ Potassium Channels; Large-Conductance Calcium-Activated Potassium Channels; Male; Membrane Transport Modulators; Muscle Contraction; Peptides; Phenylenediamines; Rats; Rats, Inbred F344; Tetraethylammonium; Urinary Bladder; Urothelium | 2014 |
Blue-gray mucocutaneous discoloration: a new adverse effect of ezogabine.
Topics: Adult; Anticonvulsants; Carbamates; Drug Eruptions; Female; Humans; Hypopigmentation; Mucous Membrane; Phenylenediamines | 2014 |
Retigabine calms seizure-induced behavior following status epilepticus.
Topics: Animals; Anticonvulsants; Anxiety; Behavior, Animal; Carbamates; Convulsants; Hippocampus; Hyperkinesis; Kainic Acid; Male; Phenylenediamines; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 2014 |
Isolation, identification and structure elucidation of two novel process-related impurities of retigabine.
Topics: Anticonvulsants; Carbamates; Carboxylic Acids; Chromatography, High Pressure Liquid; Drug Contamination; Imidazoles; Molecular Conformation; Phenylenediamines; Spectrometry, Mass, Electrospray Ionization; Technology, Pharmaceutical | 2014 |
Control of somatic membrane potential in nociceptive neurons and its implications for peripheral nociceptive transmission.
Topics: Animals; Animals, Newborn; Bradykinin; Calcium Channels, T-Type; Carbamates; Cells, Cultured; Cricetulus; Ganglia, Spinal; Humans; In Vitro Techniques; Ion Channels; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Male; Membrane Potentials; Membrane Transport Modulators; Models, Neurological; Nociceptors; Phenylenediamines; Rats; Rats, Sprague-Dawley; Spectrophotometry, Atomic | 2014 |
Long term retention of retigabine in a cohort of people with drug resistant epilepsy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamates; Drug Resistance; Epilepsy; Female; Humans; Levetiracetam; Male; Middle Aged; Phenylenediamines; Piracetam; Time; Treatment Outcome; Young Adult | 2014 |
Possible involvement of nitric oxide modulatory mechanism in the protective effect of retigabine against spinal nerve ligation-induced neuropathic pain.
Topics: Animals; Carbamates; Ligation; Male; Neuralgia; Neuroprotective Agents; Nitric Oxide; Pain Threshold; Phenylenediamines; Rats; Rats, Sprague-Dawley; Spinal Nerves | 2015 |
KCNQ/Kv7 channel activator flupirtine protects against acute stress-induced impairments of spatial memory retrieval and hippocampal LTP in rats.
Topics: Aminopyridines; Animals; Anthracenes; Carbamates; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Long-Term Potentiation; Male; Maze Learning; Memory Disorders; Nootropic Agents; Phenylenediamines; Phosphorylation; Potassium Channel Blockers; Rats, Sprague-Dawley; Spatial Memory; Stress, Psychological | 2014 |
P-retigabine: an N-propargyled retigabine with improved brain distribution and enhanced antiepileptic activity.
Topics: Action Potentials; Animals; Anticonvulsants; Carbamates; Cells, Cultured; CHO Cells; Cricetulus; Disease Models, Animal; Dose-Response Relationship, Drug; Hippocampus; KCNQ Potassium Channels; Male; Mice; Phenylenediamines; Seizures | 2015 |
Heterogeneity in Kv7 channel function in the cerebral and coronary circulation.
Topics: Animals; Basilar Artery; Carbamates; Cerebrovascular Circulation; Circle of Willis; Colforsin; Coronary Circulation; Indoles; KCNQ Potassium Channels; KCNQ1 Potassium Channel; Male; Mice; Mice, Knockout; Muscle Contraction; Muscle, Smooth, Vascular; Organ Specificity; Phenylenediamines; Potassium Channel Blockers; Pyridines; Vasoconstriction; Vasodilation; Vasodilator Agents | 2015 |
Suppression of KCNQ/M (Kv7) potassium channels in the spinal cord contributes to the sensitization of dorsal horn WDR neurons and pain hypersensitivity in a rat model of bone cancer pain.
Topics: Acetylcholine; Animals; Anthracenes; Bone Neoplasms; Carbamates; Disease Models, Animal; Female; Hyperalgesia; KCNQ Potassium Channels; Membrane Transport Modulators; Neoplasm Transplantation; Pain; Phenylenediamines; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Spinal Cord | 2015 |
Augmentation of M-type (KCNQ) potassium channels as a novel strategy to reduce stroke-induced brain injury.
Topics: Animals; Anthracenes; Carbamates; Drug Therapy, Combination; Infarction, Middle Cerebral Artery; KCNQ Potassium Channels; Male; Mice; Mice, Inbred C57BL; Phenylenediamines; Potassium Channel Blockers | 2015 |
A pharmaco-EEG study of the interaction between ethanol and retigabine in rabbits.
Topics: Animals; Anticonvulsants; Carbamates; Drug Interactions; Electroencephalography; Ethanol; Female; Frontal Lobe; Hippocampus; Male; Phenylenediamines; Rabbits | 2015 |
Thalamic Kv 7 channels: pharmacological properties and activity control during noxious signal processing.
Topics: Action Potentials; Acute Pain; Animals; Anthracenes; Brain; Carbamates; Disease Models, Animal; KCNQ Potassium Channels; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Mice; Mice, Inbred C57BL; Neurons; Pain Threshold; Phenylenediamines; Thalamus | 2015 |
The anticonvulsant retigabine is a subtype selective modulator of GABAA receptors.
Topics: Animals; Anticonvulsants; Carbamates; Cells, Cultured; Dose-Response Relationship, Drug; GABA Modulators; Hippocampus; Phenylenediamines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures | 2015 |
A retrospective evaluation of retigabine in patients with cognitive impairment with highly drug-resistant epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Carbamates; Cognition; Cognition Disorders; Cohort Studies; Epilepsy; Female; Humans; Intellectual Disability; Male; Middle Aged; Phenylenediamines; Retrospective Studies; Treatment Outcome; Young Adult | 2015 |
Potassium ion channel openers, Maxipost and Retigabine, protect against peripheral salicylate ototoxicity in rats.
Topics: Acoustic Stimulation; Animals; Carbamates; Cochlea; Cochlear Microphonic Potentials; Cytoprotection; Disease Models, Animal; Hearing Loss, Sensorineural; Indoles; KCNQ Potassium Channels; Large-Conductance Calcium-Activated Potassium Channels; Male; Otoacoustic Emissions, Spontaneous; Phenylenediamines; Potassium Channels; Rats, Sprague-Dawley; Sodium Salicylate; Tinnitus | 2015 |
Functional analysis of potassium channels in Kv7.2 G271V mutant causing early onset familial epilepsy.
Topics: Anticonvulsants; Biophysical Phenomena; Carbamates; Dose-Response Relationship, Drug; Electric Stimulation; Glycine; Green Fluorescent Proteins; HEK293 Cells; Humans; KCNQ2 Potassium Channel; Membrane Potentials; Microscopy, Fluorescence; Mutagenesis; Mutation; Patch-Clamp Techniques; Phenylenediamines; Time Factors; Valine | 2015 |
Antinociceptive Efficacy of Retigabine in the Monosodium Lodoacetate Rat Model for Osteoarthritis Pain.
Topics: Analgesics; Animals; Arthritis, Experimental; Behavior, Animal; Carbamates; Disease Models, Animal; Iodoacetates; Knee Joint; Male; Membrane Transport Modulators; Osteoarthritis; Pain; Phenylenediamines; Rats, Sprague-Dawley; Treatment Outcome | 2015 |
Synergistic Interaction of Retigabine with Levetiracetam in the Mouse Maximal Electroshock-Induced Seizure Model: A Type II Isobolographic Analysis.
Topics: Animals; Brain; Carbamates; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Electroshock; Levetiracetam; Male; Mice; Models, Statistical; Phenylenediamines; Piracetam; Seizures | 2015 |
Potent KCNQ2/3-specific channel activator suppresses in vivo epileptic activity and prevents the development of tinnitus.
Topics: Animals; Animals, Newborn; Anticonvulsants; Carbamates; Disease Models, Animal; Epilepsy; Evoked Potentials, Auditory, Brain Stem; Female; HEK293 Cells; Homeodomain Proteins; Humans; In Vitro Techniques; KCNQ Potassium Channels; KCNQ2 Potassium Channel; Male; Membrane Potentials; Mice; Mice, Inbred ICR; Mice, Knockout; Mutation; Phenylenediamines; Rats; Rats, Sprague-Dawley; Tinnitus; Transcription Factors | 2015 |
Kv7 channels in the nucleus accumbens are altered by chronic drinking and are targets for reducing alcohol consumption.
Topics: Alcohol Deterrents; Alcohol Drinking; Alcohol Withdrawal Seizures; Animals; Anthracenes; Anticonvulsants; Behavior, Animal; Carbamates; Conditioning, Operant; Genomics; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Male; Membrane Transport Modulators; Microinjections; Motor Activity; Nucleus Accumbens; Phenylenediamines; Potassium Channel Blockers; Rats, Wistar; Sumoylation; Taste Perception | 2016 |
From Dish to Bedside: Lessons Learned While Translating Findings from a Stem Cell Model of Disease to a Clinical Trial.
Topics: Amyotrophic Lateral Sclerosis; Animals; Carbamates; Clinical Trials as Topic; Drug Discovery; Humans; Induced Pluripotent Stem Cells; Mice; Models, Neurological; Motor Neurons; Mutation; Phenylenediamines; Superoxide Dismutase; Superoxide Dismutase-1; Translational Research, Biomedical | 2015 |
Inhibition of Kv7/M Channel Currents by the Local Anesthetic Chloroprocaine.
Topics: Anesthetics, Local; Animals; Carbamates; Dose-Response Relationship, Drug; Ganglia, Spinal; HEK293 Cells; Humans; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Membrane Potentials; Neurons; Patch-Clamp Techniques; Phenylenediamines; Potassium Channel Blockers; Procaine; Rats; Rats, Sprague-Dawley; Seizures | 2015 |
KCNQ channels in nociceptive cold-sensing trigeminal ganglion neurons as therapeutic targets for treating orofacial cold hyperalgesia.
Topics: Action Potentials; Animals; Carbamates; Chronic Disease; Cold Temperature; Constriction; Disease Models, Animal; Face; Hyperalgesia; KCNQ Potassium Channels; Male; Molecular Targeted Therapy; Neurons; Nociception; Organoplatinum Compounds; Oxaliplatin; Phenylenediamines; Rats, Sprague-Dawley; Thermosensing; Trigeminal Ganglion | 2015 |
Effectiveness of retigabine against levobupivacaine-induced central nervous system toxicity: a prospective, randomized animal study.
Topics: Animals; Anticonvulsants; Bupivacaine; Carbamates; Central Nervous System; KCNQ2 Potassium Channel; Levobupivacaine; Neurons; Phenylenediamines; Prospective Studies; Rabbits; Random Allocation; Seizures | 2016 |
Atomic basis for therapeutic activation of neuronal potassium channels.
Topics: Animals; Anticonvulsants; Carbamates; Fluorine; Humans; Hydrogen Bonding; KCNQ Potassium Channels; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Molecular Docking Simulation; Mutagenesis, Site-Directed; Neurons; Oocytes; Patch-Clamp Techniques; Phenylenediamines; Tryptophan; Xenopus laevis | 2015 |
M-current preservation contributes to anticonvulsant effects of valproic acid.
Topics: A Kinase Anchor Proteins; Action Potentials; Animals; Anthracenes; Anticonvulsants; Carbamates; Cells, Cultured; Drug Interactions; Female; Hippocampus; Humans; Kainic Acid; KCNQ2 Potassium Channel; Lipoylation; Male; Mice; Mice, Inbred C57BL; Muscarinic Agonists; Muscarinic Antagonists; Neurons; Phenylenediamines; Phosphorylation; Potassium Channel Blockers; Protein Processing, Post-Translational; Rats; Receptor, Muscarinic M1; Recombinant Fusion Proteins; Seizures; Signal Transduction; Superior Cervical Ganglion; Valproic Acid | 2015 |
A case report: retigabine induced oral mucosal dyspigmentation of the hard palate.
Topics: Aged; Anticonvulsants; Carbamates; Humans; Male; Mouth Mucosa; Palate, Hard; Phenylenediamines; Pigmentation Disorders | 2015 |
Inhibitory effects of retigabine, a Kv7 channel activator, on mechanosensitive primary bladder afferent activities and nociceptive behaviors in rats.
Topics: Animals; Behavior, Animal; Carbamates; Female; Mechanotransduction, Cellular; Membrane Transport Modulators; Neurons, Afferent; Nociception; Phenylenediamines; Potassium Channels, Voltage-Gated; Rats; Rats, Sprague-Dawley; Urinary Bladder | 2017 |
The Sensorless Pore Module of Voltage-gated K+ Channel Family 7 Embodies the Target Site for the Anticonvulsant Retigabine.
Topics: Amino Acid Substitution; Anticonvulsants; Carbamates; Humans; Ion Channel Gating; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Models, Molecular; Mutation, Missense; Phenylenediamines | 2016 |
Effects of cold temperatures on the excitability of rat trigeminal ganglion neurons that are not for cold sensing.
Topics: Action Potentials; Animals; Carbamates; Cell Membrane; Cold Temperature; In Vitro Techniques; Membrane Transport Modulators; Neurons; Nociceptors; Patch-Clamp Techniques; Phenylenediamines; Potassium Channels; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Thermosensing; Trigeminal Ganglion; TRPM Cation Channels | 2017 |
Expression and function of Kv7.4 channels in rat cardiac mitochondria: possible targets for cardioprotection.
Topics: Aminopyridines; Animals; Carbamates; KCNQ Potassium Channels; Male; Membrane Potentials; Mitochondria, Heart; Myocytes, Cardiac; Phenylenediamines; Potassium Channel Blockers; Rats | 2016 |
Activation of KCNQ channels located on the skeletal muscle membrane by retigabine and its influence on the maximal muscle force in rat muscle strips.
Topics: Animals; Anticonvulsants; Carbamates; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Techniques; KCNQ Potassium Channels; Male; Membrane Transport Modulators; Muscle Contraction; Muscle Relaxation; Muscle Strength; Muscle, Skeletal; Phenylenediamines; Potassium Channel Blockers; Rats, Wistar | 2016 |
Adjunctive retigabine in refractory focal epilepsy: Postmarketing experience at four tertiary epilepsy care centers in Germany.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamates; Child; Death, Sudden, Cardiac; Drug Resistant Epilepsy; Electrocardiography; Epilepsies, Partial; Female; Germany; Humans; Incidence; Male; Middle Aged; Phenylenediamines; Product Surveillance, Postmarketing; Retrospective Studies; Seizures; Tertiary Care Centers; Treatment Outcome; Young Adult | 2016 |
Profile of retigabine-induced neuronal apoptosis in the developing rat brain.
Topics: Animals; Animals, Newborn; Anticonvulsants; Apoptosis; Brain; Carbamates; Dose-Response Relationship, Drug; Male; Neurons; Phenylenediamines; Rats; Rats, Sprague-Dawley | 2016 |
Retigabine holds KV7 channels open and stabilizes the resting potential.
Topics: Animals; Anticonvulsants; Carbamates; Humans; Ion Channel Gating; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Membrane Potentials; Phenylenediamines; Protein Domains; Protein Multimerization; Xenopus | 2016 |
Retigabine, a Kv7.2/Kv7.3-Channel Opener, Attenuates Drug-Induced Seizures in Knock-In Mice Harboring Kcnq2 Mutations.
Topics: Animals; Carbamates; Gene Knock-In Techniques; Humans; Ion Channel Gating; Kainic Acid; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Mice; Models, Molecular; Mutation; Phenylenediamines; Protein Structure, Tertiary; Seizures | 2016 |
Comparison of the long-term behavioral effects of neonatal exposure to retigabine or phenobarbital in rats.
Topics: Animals; Animals, Newborn; Anticonvulsants; Anxiety; Behavior, Animal; Carbamates; Cognition; Dose-Response Relationship, Drug; Female; Male; Memory; Phenobarbital; Phenylenediamines; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley | 2016 |
The Voltage Activation of Cortical KCNQ Channels Depends on Global PIP2 Levels.
Topics: Animals; Carbamates; Cerebral Cortex; Female; HEK293 Cells; Hippocalcin; Humans; Ion Channel Gating; KCNQ3 Potassium Channel; Male; Membrane Potentials; Mice, Inbred C57BL; Mice, Knockout; Neurons; Phenylenediamines; Phosphatidylinositol 4,5-Diphosphate; Pyramidal Cells | 2016 |
Synthesis and Evaluation of Potent KCNQ2/3-Specific Channel Activators.
Topics: Animals; Carbamates; CHO Cells; Conserved Sequence; Cricetinae; Cricetulus; Drug Synergism; Halogenation; Humans; Ion Channel Gating; KCNQ Potassium Channels; Membrane Transport Modulators; Phenylenediamines; Protein Subunits; Structure-Activity Relationship; Tryptophan | 2016 |
A Kv7.2 mutation associated with early onset epileptic encephalopathy with suppression-burst enhances Kv7/M channel activity.
Topics: Animals; Ankyrins; Anticonvulsants; Carbamates; CHO Cells; Cricetulus; Electric Stimulation; Female; Hippocampus; Humans; Indoles; KCNQ2 Potassium Channel; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Phenylenediamines; Polymorphism, Single Nucleotide; Potassium Channel Blockers; Pyridines; Spasms, Infantile | 2016 |
Spontaneous activity in C-fibres after partial damage to the saphenous nerve in mice: Effects of retigabine.
Topics: Action Potentials; Animals; Axotomy; Carbamates; Disease Models, Animal; Male; Membrane Transport Modulators; Mice; Nerve Fibers; Neuralgia; Neuroma; Peripheral Nerves; Phenylenediamines | 2016 |
KCNQ channel openers reverse depressive symptoms via an active resilience mechanism.
Topics: Adaptation, Psychological; Animals; Antidepressive Agents; Behavior, Animal; Carbamates; Depressive Disorder, Major; Disease Models, Animal; Dopaminergic Neurons; Electrophysiological Phenomena; Humans; KCNQ3 Potassium Channel; Male; Membrane Transport Modulators; Mice; Mice, Inbred C57BL; Phenylenediamines; Resilience, Psychological; Stress, Psychological; Ventral Tegmental Area | 2016 |
Effects of novel subtype selective M-current activators on spinal reflexes in vitro: Comparison with retigabine.
Topics: Anilides; Animals; Anticonvulsants; Bridged Bicyclo Compounds; Carbamates; Female; Ganglia, Spinal; KCNQ Potassium Channels; Male; Mice; Phenylenediamines; Reflex; Spinal Cord | 2016 |
Activation of neuronal Kv7/KCNQ/M-channels by the opener QO58-lysine and its anti-nociceptive effects on inflammatory pain in rodents.
Topics: Animals; Anthracenes; Biological Availability; Carbamates; Dose-Response Relationship, Drug; HEK293 Cells; Humans; KCNQ Potassium Channels; Lysine; Male; Membrane Potentials; Pain Measurement; Phenylenediamines; Rats | 2016 |
The pan-Kv7 (KCNQ) Channel Opener Retigabine Inhibits Striatal Excitability by Direct Action on Striatal Neurons In Vivo.
Topics: Animals; Anticonvulsants; Biomarkers; Carbamates; Corpus Striatum; Cortical Excitability; Dopamine Antagonists; Drug Interactions; Gene Expression Regulation; Haloperidol; Injections, Intraventricular; KCNQ Potassium Channels; Male; Membrane Transport Modulators; Nerve Tissue Proteins; Neurons, Afferent; Neurons, Efferent; Nucleus Accumbens; Phenylenediamines; Protein Subunits; Proto-Oncogene Proteins c-fos; Rats, Wistar; Synaptic Transmission | 2017 |
Sequence determinants of subtype-specific actions of KCNQ channel openers.
Topics: Carbamates; HEK293 Cells; Humans; Ion Channel Gating; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Membrane Transport Modulators; Models, Molecular; Mutation; Phenylenediamines | 2017 |
The anticonvulsant retigabine suppresses neuronal K
Topics: Animals; Anticonvulsants; Carbamates; Cell Line; HEK293 Cells; Humans; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Membrane Potentials; Neurons; Phenylenediamines; Rats; Shab Potassium Channels | 2016 |
Retigabine diminishes the effects of acetylcholine, adrenaline and adrenergic agonists on the spontaneous activity of guinea pig smooth muscle strips in vitro.
Topics: Acetylcholine; Adrenergic Agonists; Animals; Anthracenes; Carbamates; Cholinergic Agonists; Clonidine; Drug Interactions; Epinephrine; Guinea Pigs; Isoproterenol; KCNQ Potassium Channels; Membrane Potentials; Methoxamine; Muscle Contraction; Muscle, Smooth; Phenylenediamines; Random Allocation; Stomach; Tissue Culture Techniques | 2017 |
Activation of KCNQ Channels Suppresses Spontaneous Activity in Dorsal Root Ganglion Neurons and Reduces Chronic Pain after Spinal Cord Injury.
Topics: Animals; Behavior, Animal; Carbamates; Chronic Pain; Disease Models, Animal; Ganglia, Spinal; KCNQ Potassium Channels; Male; Membrane Transport Modulators; Phenylenediamines; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries | 2017 |
Kv7 voltage-activated potassium channel inhibitors reduce fluid resuscitation requirements after hemorrhagic shock in rats.
Topics: Animals; Carbamates; Indoles; KCNQ Potassium Channels; Male; Phenylenediamines; Potassium Channel Blockers; Pyridines; Rats; Rats, Sprague-Dawley; Resuscitation; Shock, Hemorrhagic | 2017 |
Targeting Kv7 channels in pain pathways.
Topics: Aminopyridines; Animals; Carbamates; Deafness; Epilepsy; Humans; Inflammation; KCNQ Potassium Channels; Long QT Syndrome; Mutation; Neurons; Pain; Pain Management; Phenylenediamines; Protein Conformation | 2017 |
Sensitive inexpensive spectrophotometric and spectrofluorimetric analysis of ezogabine, levetiracetam and topiramate in tablet formulations using Hantzsch condensation reaction.
Topics: Carbamates; Drug Combinations; Drug Stability; Formaldehyde; Fructose; Hydrogen-Ion Concentration; Levetiracetam; Limit of Detection; Linear Models; Pentanones; Phenylenediamines; Piracetam; Reproducibility of Results; Spectrometry, Fluorescence; Tablets; Topiramate | 2017 |
XE991 and Linopirdine Are State-Dependent Inhibitors for Kv7/KCNQ Channels that Favor Activated Single Subunits.
Topics: Animals; Anthracenes; Carbamates; CHO Cells; Cricetinae; Cricetulus; Indoles; KCNQ1 Potassium Channel; KCNQ2 Potassium Channel; Kinetics; Membrane Potentials; Mutation; Patch-Clamp Techniques; Phenylenediamines; Potassium Channel Blockers; Protein Subunits; Pyridines; Rats | 2017 |
Modulation of the heart's electrical properties by the anticonvulsant drug retigabine.
Topics: Action Potentials; Animals; Anticonvulsants; Arrhythmias, Cardiac; Calcium Channel Blockers; Calcium Channels, L-Type; Carbamates; Cell Line; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ganglia, Sympathetic; Ganglionic Blockers; Guinea Pigs; Heart Conduction System; Heart Rate; Humans; Induced Pluripotent Stem Cells; Ion Channels; Isolated Heart Preparation; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Norepinephrine; Phenylenediamines; Potassium Channel Blockers; Rats, Sprague-Dawley; Risk Assessment; Time Factors; Transfection; Voltage-Gated Sodium Channel Blockers | 2017 |
Effect of M-current modulation on mammalian vestibular responses to transient head motion.
Topics: Animals; Anthracenes; Carbamates; Evoked Potentials; Female; Head Movements; KCNQ Potassium Channels; Membrane Transport Modulators; Mice; Mice, Inbred C57BL; Motor Neurons; Phenylenediamines; Vestibule, Labyrinth | 2017 |
The possibility of adverse effect of Kv7-channel opener retigabine on memory processes in rats.
Topics: Animals; Anticonvulsants; Avoidance Learning; Carbamates; Dose-Response Relationship, Drug; Fear; Male; Maze Learning; Phenylenediamines; Rats; Rats, Wistar; Spatial Memory | 2017 |
Beneficial Combination of Lacosamide with Retigabine in Experimental Animals: An Isobolographic Analysis.
Topics: Acetamides; Animals; Anticonvulsants; Brain; Carbamates; Dose-Response Relationship, Drug; Drug Combinations; Electroshock; Lacosamide; Male; Mice; Phenylenediamines; Psychomotor Performance; Seizures | 2018 |
PIP2 mediates functional coupling and pharmacology of neuronal KCNQ channels.
Topics: Animals; Anticonvulsants; Carbamates; Ion Channel Gating; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Neurons; Phenylenediamines; Phosphatidylinositol 4,5-Diphosphate; Phospholipids; Potassium Channels, Voltage-Gated; Xenopus laevis | 2017 |
Pharmacogenetics of KCNQ channel activation in 2 potassium channelopathy mouse models of epilepsy.
Topics: Animals; Anticonvulsants; Atrioventricular Block; Behavior, Animal; Bradycardia; Carbamates; Channelopathies; Death, Sudden; Disease Models, Animal; Drug Resistance; Drug Resistant Epilepsy; Electroencephalography; Epilepsy; Gene Expression Profiling; Heart Rate; KCNQ Potassium Channels; KCNQ1 Potassium Channel; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Kv1.1 Potassium Channel; Mice; Nerve Tissue Proteins; Pharmacogenetics; Pharmacogenomic Testing; Phenylenediamines; RNA, Messenger; Transcriptome | 2018 |
Centipedes subdue giant prey by blocking KCNQ channels.
Topics: Animals; Anticonvulsants; Arthropod Venoms; Arthropods; Carbamates; KCNQ Potassium Channels; Mice; Nervous System Diseases; Phenylenediamines; Predatory Behavior; Respiratory System Abnormalities | 2018 |
Retigabine ameliorates acute stress-induced impairment of spatial memory retrieval through regulating USP2 signaling pathways in hippocampal CA1 area.
Topics: Animals; Autophagy; beta Catenin; CA1 Region, Hippocampal; Carbamates; Male; Memory Disorders; Mental Recall; Muscle Proteins; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phenylenediamines; Rats; Receptors, AMPA; Repressor Proteins; Signal Transduction; Stress, Psychological; Ubiquitin Thiolesterase | 2018 |
Restoration of Kv7 Channel-Mediated Inhibition Reduces Cued-Reinstatement of Cocaine Seeking.
Topics: Action Potentials; Adaptation, Physiological; Animals; Carbamates; Cocaine-Related Disorders; Cues; Drug-Seeking Behavior; KCNQ Potassium Channels; Male; Membrane Transport Modulators; Phenylenediamines; Prefrontal Cortex; Rats; Rats, Long-Evans; Rats, Sprague-Dawley | 2018 |
Functional up-regulation of the M-current by retigabine contrasts hyperexcitability and excitotoxicity on rat hypoglossal motoneurons.
Topics: Action Potentials; Animals; Animals, Newborn; Anticonvulsants; Carbamates; Excitatory Postsynaptic Potentials; Hypoglossal Nerve; Motor Neurons; Phenylenediamines; Potassium Channels; Rats; Rats, Wistar; Reactive Oxygen Species; Synaptic Transmission; Up-Regulation | 2018 |
Inhibition of striatal cholinergic interneuron activity by the Kv7 opener retigabine and the nonsteroidal anti-inflammatory drug diclofenac.
Topics: Acetylcholine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbamates; Corpus Striatum; Diclofenac; Excitatory Postsynaptic Potentials; Interneurons; Male; Membrane Transport Modulators; Mice, Transgenic; Phenylenediamines; Potassium Channel Blockers; Potassium Channels; Tissue Culture Techniques | 2018 |
egl-4 modulates electroconvulsive seizure duration in C. elegans.
Topics: Animals; Anticonvulsants; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Carbamates; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Electroshock; Phenylenediamines; Recovery of Function; Seizures; Signal Transduction | 2018 |
Retigabine attenuates focal cerebral ischemic injury through inhibiting mitochondria-dependent apoptotic pathway.
Topics: Animals; Apoptosis; Brain Injuries; Carbamates; Caspase 3; Disease Models, Animal; Glutathione; JNK Mitogen-Activated Protein Kinases; Male; Malondialdehyde; Mice; Mice, Inbred C57BL; Mitochondria; Oxidative Stress; Phenylenediamines; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Superoxide Dismutase | 2018 |
One drug-sensitive subunit is sufficient for a near-maximal retigabine effect in KCNQ channels.
Topics: Animals; Anticonvulsants; Carbamates; KCNQ3 Potassium Channel; Mutation; Phenylenediamines; Xenopus laevis | 2018 |
Ancient and modern anticonvulsants act synergistically in a KCNQ potassium channel binding pocket.
Topics: Animals; Anticonvulsants; Carbamates; Drug Synergism; Hemiterpenes; KCNQ Potassium Channels; Mallotus Plant; Mice; Pentanoic Acids; Phenylenediamines; Phytotherapy; Seizures; Xenopus laevis | 2018 |
Micelle and inclusion complex enhanced spectrofluorimetric methods for determination of Retigabine: Application in pharmaceutical and biological analysis.
Topics: Animals; Anticonvulsants; Carbamates; Drug Monitoring; Drug Stability; Limit of Detection; Micelles; Phenylenediamines; Rabbits; Sodium Dodecyl Sulfate; Spectrometry, Fluorescence; Tablets | 2019 |
Pore- and voltage sensor-targeted KCNQ openers have distinct state-dependent actions.
Topics: Anticonvulsants; Carbamates; HEK293 Cells; Humans; KCNQ2 Potassium Channel; Mutation; Patch-Clamp Techniques; Phenylenediamines | 2018 |
Activation of KCNQ Channels Prevents Paclitaxel-Induced Peripheral Neuropathy and Associated Neuropathic Pain.
Topics: Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Carbamates; Cell Line, Tumor; Drug Repositioning; Humans; KCNQ Potassium Channels; Male; Neuralgia; Neurons; Neuroprotective Agents; Paclitaxel; Peripheral Nervous System Diseases; Phenylenediamines; Random Allocation; Rats, Sprague-Dawley | 2019 |
The dual role of KCNQ/M channels upon OGD or OGD/R insults in cultured cortical neurons of mice: Timing is crucial in targeting M-channels against ischemic injur ies.
Topics: Animals; Carbamates; Female; Glucose; Glutamic Acid; KCNQ Potassium Channels; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Neurons; Oxygen; Phenylenediamines; Reperfusion Injury | 2019 |
The K
Topics: Animals; Carbamates; Isometric Contraction; Large-Conductance Calcium-Activated Potassium Channels; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Muscle Contraction; Muscle, Smooth; Myocytes, Smooth Muscle; Neurons, Afferent; Phenylenediamines; Urinary Bladder | 2019 |
Retigabine protects the blood-brain barrier by regulating tight junctions between cerebral vascular endothelial cells in cerebral ischemia-reperfusion rats.
Topics: Animals; Blood-Brain Barrier; Brain Ischemia; Carbamates; Cerebral Infarction; Claudin-5; Endothelial Cells; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Occludin; Permeability; Phenylenediamines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Tight Junction Proteins; Tight Junctions | 2018 |
An Investigation into Retigabine (Ezogabine) Associated Dyspigmentation in Rat Eyes by MALDI Imaging Mass Spectrometry.
Topics: Animals; Carbamates; Dimerization; Male; Melanins; Phenylenediamines; Rats; Rats, Long-Evans; Retinal Pigments; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Uvea | 2019 |
KCNQ/M-channels regulate mouse vagal bronchopulmonary C-fiber excitability and cough sensitivity.
Topics: Action Potentials; Animals; Anthracenes; Carbamates; Cough; KCNQ Potassium Channels; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Lung; Male; Mice; Mice, Inbred C57BL; Models, Animal; Nerve Tissue Proteins; Nodose Ganglion; Patch-Clamp Techniques; Phenylenediamines; RNA, Messenger; Transcriptome; Vagus Nerve | 2019 |
Treatment of myotonia congenita with retigabine in mice.
Topics: Action Potentials; Animals; Behavior, Animal; Carbamates; Chloride Channels; In Vitro Techniques; KCNQ Potassium Channels; Membrane Potentials; Membrane Transport Modulators; Mice; Muscle Contraction; Muscle, Skeletal; Myotonia Congenita; Phenylenediamines; Psychomotor Performance | 2019 |
Reversal of a Treatment-Resistant, Depression-Related Brain State with the Kv7 Channel Opener Retigabine.
Topics: Animals; Anticonvulsants; Brain; Carbamates; Depressive Disorder, Treatment-Resistant; Diet, High-Fat; Female; KCNQ1 Potassium Channel; Male; Mice; Mice, Inbred C57BL; Organ Culture Techniques; Phenylenediamines | 2019 |
Development of an Electrophysiological Assay for Kv7 Modulators on IonWorks Barracuda.
Topics: Aminopyridines; Carbamates; Cells, Cultured; Drug Development; Electrophysiological Phenomena; HEK293 Cells; High-Throughput Screening Assays; Humans; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Patch-Clamp Techniques; Phenylenediamines | 2019 |
Enhancing KCNQ Channel Activity Improves Neurobehavioral Recovery after Spinal Cord Injury.
Topics: Animals; Carbamates; KCNQ Potassium Channels; Locomotion; Male; Membrane Transport Modulators; Phenylenediamines; Rats; Rats, Sprague-Dawley; Recovery of Function; Spinal Cord Injuries; Thoracic Vertebrae | 2020 |
Antinociceptive Efficacy of Retigabine and Flupirtine for Gout Arthritis Pain.
Topics: Aminopyridines; Analgesics; Animals; Arthritis, Experimental; Arthritis, Gouty; Behavior, Animal; Carbamates; Disease Models, Animal; Hyperalgesia; KCNQ Potassium Channels; Male; Pain; Phenylenediamines; Rats; Rats, Sprague-Dawley; Uric Acid | 2020 |
Molecular Mechanisms and Structural Basis of Retigabine Analogues in Regulating KCNQ2 Channel.
Topics: Amino Acid Sequence; Binding Sites; Carbamates; Hydrogen Bonding; Ion Channel Gating; KCNQ2 Potassium Channel; Membrane Transport Modulators; Molecular Docking Simulation; Molecular Dynamics Simulation; Phenylenediamines; Protein Binding; Protein Conformation; Structure-Activity Relationship | 2020 |
An Electrochemophysiological Microarray for Real-Time Monitoring and Quantification of Multiple Ions in the Brain of a Freely Moving Rat.
Topics: Animals; Anticonvulsants; Brain; Calcium; Carbamates; Diamines; Electrochemical Techniques; Epilepsy; Hydrogen-Ion Concentration; Ionophores; Limit of Detection; Male; Microelectrodes; Monitoring, Physiologic; Phenylenediamines; Potassium; Rats, Wistar; Sodium; Zonisamide | 2020 |
Combining endocannabinoids with retigabine for enhanced M-channel effect and improved KV7 subtype selectivity.
Topics: Animals; Carbamates; Endocannabinoids; Humans; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Oocytes; Phenylenediamines; Xenopus laevis | 2020 |
Chemical regulation of Kv7 channels: Diverse scaffolds, sites, and mechanisms of action.
Topics: Carbamates; Endocannabinoids; Phenylenediamines | 2020 |
Functional and behavioral signatures of Kv7 activator drug subtypes.
Topics: Anilides; Animals; Animals, Genetically Modified; Anticonvulsants; Bridged Bicyclo Compounds; Calcium; Carbamates; Disease Models, Animal; Drug Resistance; Epilepsy; In Vitro Techniques; KCNQ Potassium Channels; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Luminescent Proteins; Membrane Potentials; Mutation; Neurons; Optical Imaging; Patch-Clamp Techniques; Phenylenediamines; Seizures; Zebrafish | 2020 |
Molecular basis for ligand activation of the human KCNQ2 channel.
Topics: Action Potentials; Benzamides; Binding Sites; Carbamates; Cryoelectron Microscopy; Humans; KCNQ2 Potassium Channel; Ligands; Molecular Dynamics Simulation; Mutagenesis; Phenylenediamines; Protein Binding; Protein Structure, Tertiary; Pyridines | 2021 |
Gabapentin treatment in a patient with KCNQ2 developmental epileptic encephalopathy.
Topics: Age of Onset; Animals; Anticonvulsants; Carbamates; Cells, Cultured; Child; CHO Cells; Cricetinae; Cricetulus; Electroencephalography; Epilepsy; Female; Gabapentin; Humans; KCNQ2 Potassium Channel; Mutation; Phenylenediamines; Precision Medicine; Rats; Treatment Outcome | 2020 |
Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs.
Topics: Animals; Carbamates; Cryoelectron Microscopy; Humans; Indoles; KCNQ Potassium Channels; Mutation; Phenylenediamines; Phosphatidylinositol 4,5-Diphosphate; Protein Domains; Pyridines; Sf9 Cells; Spodoptera | 2021 |
The Role of Potassium Channels in Chronic Stress-Induced Brain Injury.
Topics: Animals; Brain; Brain Injuries; Carbamates; Disease Models, Animal; Female; Humans; Neuroprotective Agents; Phenylenediamines; Potassium Channel Blockers; Potassium Channels; Rats; RNA-Seq; Signal Transduction; Stress, Psychological | 2021 |
Beneficial effect of retigabine on memory in rats receiving ethanol.
Topics: Animals; Anticonvulsants; Brain; Carbamates; Disease Models, Animal; Ethanol; Hippocampus; Learning; Male; Maze Learning; Memory; Memory Disorders; Phenylenediamines; Rats; Rats, Wistar | 2021 |
KCNQ3 is the principal target of retigabine in CA1 and subicular excitatory neurons.
Topics: Action Potentials; Animals; Anticonvulsants; CA1 Region, Hippocampal; Carbamates; Female; KCNQ3 Potassium Channel; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Patch-Clamp Techniques; Phenylenediamines; Pyramidal Cells | 2021 |
Kcnq2/Kv7.2 controls the threshold and bi-hemispheric symmetry of cortical spreading depolarization.
Topics: Anilides; Animals; Brain; Bridged Bicyclo Compounds; Carbamates; Cortical Spreading Depression; KCNQ2 Potassium Channel; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins; Organ Culture Techniques; Phenylenediamines | 2021 |
The K
Topics: Animals; Anticonvulsants; Carbamates; Humans; Male; Organophosphates; Pharmaceutical Preparations; Phenylenediamines; Rats; Rats, Sprague-Dawley; Status Epilepticus; Time-to-Treatment | 2021 |
Discovery of HN37 as a Potent and Chemically Stable Antiepileptic Drug Candidate.
Topics: Animals; Anticonvulsants; Carbamates; Disease Models, Animal; Dogs; Drug Design; Drug Evaluation, Preclinical; Drug Stability; Electroshock; Half-Life; Humans; KCNQ Potassium Channels; Mice; Phenylenediamines; Protein Isoforms; Rats; Rats, Sprague-Dawley; Seizures; Structure-Activity Relationship | 2021 |
Nicotine enhances object recognition memory through inhibition of voltage-dependent potassium 7 channels in the medial prefrontal cortex of mice.
Topics: Animals; Anthracenes; Carbamates; Male; Memory; Mice, Inbred C57BL; Nicotine; Phenylenediamines; Potassium Channels, Voltage-Gated; Prefrontal Cortex; Recognition, Psychology; Stimulation, Chemical | 2021 |
The novel dual-mechanism Kv7 potassium channel/TSPO receptor activator GRT-X is more effective than the Kv7 channel opener retigabine in the 6-Hz refractory seizure mouse model.
Topics: Animals; Anticonvulsants; Carbamates; CHO Cells; Cricetulus; Dose-Response Relationship, Drug; Electroshock; Male; Mice; Mice, Inbred DBA; Mice, Transgenic; Phenylenediamines; Potassium Channels, Voltage-Gated; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, GABA; Seizures; Treatment Outcome | 2022 |
Lamotrigine and retigabine increase motor threshold in transcranial magnetic stimulation at the dose required to produce an antiepileptic effect against maximal electroshock-induced seizure in rats.
Topics: Animals; Anticonvulsants; Carbamates; Electroshock; Evoked Potentials, Motor; Lamotrigine; Male; Phenylenediamines; Rats; Rats, Sprague-Dawley; Seizures; Transcranial Magnetic Stimulation | 2022 |
Carba Analogues of Flupirtine and Retigabine with Improved Oxidation Resistance and Reduced Risk of Quinoid Metabolite Formation.
Topics: Aminopyridines; Carbamates; KCNQ Potassium Channels; Phenylenediamines | 2022 |
Removal of KCNQ2 from parvalbumin-expressing interneurons improves anti-seizure efficacy of retigabine.
Topics: Animals; Carbamates; Interneurons; KCNQ2 Potassium Channel; Mice; Nerve Tissue Proteins; Parvalbumins; Phenylenediamines | 2022 |
Acute retigabine-induced effects on myelinated motor axons in amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Axons; Carbamates; Humans; Motor Neurons; Phenylenediamines | 2022 |
Retigabine suppresses loss of force in mouse models of hypokalaemic periodic paralysis.
Topics: Animals; Carbamates; Hypokalemic Periodic Paralysis; Mice; Muscle, Skeletal; Phenylenediamines | 2023 |
Acute Treatment with the M-Channel (K
Topics: Animals; Brain Injuries, Traumatic; Carbamates; Epilepsy, Post-Traumatic; Mice; Seizures | 2023 |