ezlopitant has been researched along with quinidine in 2 studies
Studies (ezlopitant) | Trials (ezlopitant) | Recent Studies (post-2010) (ezlopitant) | Studies (quinidine) | Trials (quinidine) | Recent Studies (post-2010) (quinidine) |
---|---|---|---|---|---|
22 | 2 | 1 | 6,608 | 387 | 594 |
Protein | Taxonomy | ezlopitant (IC50) | quinidine (IC50) |
---|---|---|---|
Voltage-dependent L-type calcium channel subunit alpha-1F | Homo sapiens (human) | 6.4 | |
Cholinesterase | Homo sapiens (human) | 1.23 | |
ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | 10 | |
ATP-dependent translocase ABCB1 | Homo sapiens (human) | 3.32 | |
Cytochrome P450 2D26 | Rattus norvegicus (Norway rat) | 2.8 | |
Cytochrome P450 2D6 | Homo sapiens (human) | 0.3532 | |
Potassium voltage-gated channel subfamily A member 5 | Homo sapiens (human) | 7.3 | |
Cholinesterase | Equus caballus (horse) | 7.37 | |
Voltage-dependent L-type calcium channel subunit alpha-1D | Homo sapiens (human) | 6.4 | |
Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | 0.7882 | |
Voltage-dependent L-type calcium channel subunit alpha-1S | Homo sapiens (human) | 6.4 | |
Voltage-dependent L-type calcium channel subunit alpha-1C | Homo sapiens (human) | 6.4 | |
Sodium channel protein type 5 subunit alpha | Homo sapiens (human) | 6.9 | |
Potassium voltage-gated channel subfamily D member 2 | Rattus norvegicus (Norway rat) | 2.2 |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 2 (100.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Obach, RS | 1 |
Margolis, JM; Obach, RS | 1 |
2 other study(ies) available for ezlopitant and quinidine
Article | Year |
---|---|
Metabolism of ezlopitant, a nonpeptidic substance P receptor antagonist, in liver microsomes: enzyme kinetics, cytochrome P450 isoform identity, and in vitro-in vivo correlation.
Topics: Animals; Benzylamines; Bridged Bicyclo Compounds, Heterocyclic; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dogs; Enzyme Inhibitors; Guinea Pigs; Haplorhini; Humans; Isoenzymes; Ketoconazole; Kinetics; Metabolic Clearance Rate; Microsomes, Liver; Neurokinin-1 Receptor Antagonists; Quinidine; Rats; Species Specificity; Sulfaphenazole; Tritium; Troleandomycin | 2000 |
Impact of nonspecific binding to microsomes and phospholipid on the inhibition of cytochrome P4502D6: implications for relating in vitro inhibition data to in vivo drug interactions.
Topics: Benzylamines; Bridged Bicyclo Compounds, Heterocyclic; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Drug Interactions; Enzyme Inhibitors; Ethanolamines; Fluoxetine; Humans; Imipramine; In Vitro Techniques; Microsomes; Phospholipids; Protein Binding; Quinidine | 2003 |