Page last updated: 2024-09-04

ezetimibe and tacrolimus

ezetimibe has been researched along with tacrolimus in 8 studies

Compound Research Comparison

Studies
(ezetimibe)
Trials
(ezetimibe)
Recent Studies (post-2010)
(ezetimibe)
Studies
(tacrolimus)
Trials
(tacrolimus)
Recent Studies (post-2010) (tacrolimus)
2,4845631,46517,7572,3196,661

Protein Interaction Comparison

ProteinTaxonomyezetimibe (IC50)tacrolimus (IC50)
Bile salt export pumpHomo sapiens (human)7.18
Cytochrome P450 3A4Homo sapiens (human)0.58
Cytochrome P450 3A5Homo sapiens (human)0.385
Serine/threonine-protein kinase mTORHomo sapiens (human)0.0021
Peptidyl-prolyl cis-trans isomerase FKBP1AHomo sapiens (human)0.2547
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoformHomo sapiens (human)0.0148
Splicing factor 3B subunit 3Homo sapiens (human)0.0123
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)3.3
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)3.7

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (37.50)29.6817
2010's4 (50.00)24.3611
2020's1 (12.50)2.80

Authors

AuthorsStudies
Chang, TK; Ensom, MH; Kiang, TK1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Heemann, U; Kohnle, M; Kribben, A; Philipp, T; Pietruck, F; Witzke, O1
Engel, A; Hanke, U; Keiser, M; Lütjohann, D; Modess, C; Nassif, A; Oswald, S; Runge, D; Siegmund, W; Ulrich, A; Weitschies, W1
Bašić-Jukić, N; Sabljić, Z1

Reviews

2 review(s) available for ezetimibe and tacrolimus

ArticleYear
UDP-glucuronosyltransferases and clinical drug-drug interactions.
    Pharmacology & therapeutics, 2005, Volume: 106, Issue:1

    Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic

2005
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

2 trial(s) available for ezetimibe and tacrolimus

ArticleYear
Ezetimibe for the treatment of uncontrolled hypercholesterolemia in patients with high-dose statin therapy after renal transplantation.
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2006, Volume: 6, Issue:1

    Topics: Adult; Aged; Anticholesteremic Agents; Azetidines; Cholesterol; Cyclosporine; Drug Therapy, Combination; Ezetimibe; Fatty Acids, Monounsaturated; Female; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Kidney Transplantation; Liver; Male; Middle Aged; Muscle, Skeletal; Pravastatin; Simvastatin; Tacrolimus

2006
Drug interactions between the immunosuppressant tacrolimus and the cholesterol absorption inhibitor ezetimibe in healthy volunteers.
    Clinical pharmacology and therapeutics, 2011, Volume: 89, Issue:4

    Topics: Administration, Oral; Adult; Animals; Anticholesteremic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azetidines; Cell Line; Cross-Over Studies; Dogs; Drug Interactions; Ezetimibe; Female; Glucuronosyltransferase; Humans; Immunosuppressive Agents; In Vitro Techniques; Male; Tacrolimus; Young Adult

2011

Other Studies

4 other study(ies) available for ezetimibe and tacrolimus

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
New drugs.
    Canadian family physician Medecin de famille canadien, 2004, Volume: 50

    Topics: Administration, Topical; Adult; Anti-Bacterial Agents; Anticholesteremic Agents; Azetidines; Child; Drug Therapy; Ezetimibe; Humans; Immunosuppressive Agents; Ketolides; Pharmaceutical Preparations; Tacrolimus

2004
Toxic myopathy and liver damage caused by concomitant therapy with remdesivir, atorvastatin, ezetimibe, and tacrolimus in a renal transplant patient with recently treated SARS-CoV-2 induced pneumonia: A case report.
    Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy, 2022, Volume: 26, Issue:2

    Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Atorvastatin; COVID-19 Drug Treatment; Ezetimibe; Humans; Kidney Transplantation; Liver; Myotoxicity; Pneumonia; SARS-CoV-2; Tacrolimus

2022