ezetimibe has been researched along with sch 60663 in 18 studies
| Studies (ezetimibe) | Trials (ezetimibe) | Recent Studies (post-2010) (ezetimibe) | Studies (sch 60663) | Trials (sch 60663) | Recent Studies (post-2010) (sch 60663) |
|---|---|---|---|---|---|
| 2,484 | 563 | 1,465 | 23 | 4 | 11 |
| Protein | Taxonomy | ezetimibe (IC50) | sch 60663 (IC50) |
|---|---|---|---|
| Niemann-Pick C1-like 1 protein | Canis lupus familiaris (dog) | 0.06 | |
| Niemann-Pick C1-like 1 protein | Macaca mulatta (Rhesus monkey) | 0.03 | |
| NPC1-like intracellular cholesterol transporter 1 | Rattus norvegicus (Norway rat) | 0.58 | |
| NPC1-like intracellular cholesterol transporter 1 | Homo sapiens (human) | 0.3 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 8 (44.44) | 29.6817 |
| 2010's | 8 (44.44) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Davis, HR; Vaccaro, WD | 1 |
| Altmann, SW; Browne, ME; Burnett, DA; Caplen, MA; Clader, JW; Davis, HR; Zhau, H | 1 |
| Auerbach, B; Barton, T; Bousley, R; Cai, H; Davis, J; Esmaiel, N; Larsen, SD; Mertz, T; Mueller, SB; Olsen, K; Pfefferkorn, JA; Sorenson, R; Van Huis, C; Welch, K; Winters, T; Wolfram, TJ; Wu, C | 1 |
| Canet, MJ; Cherrington, NJ; Fisher, CD; Hardwick, RN; Street, SM | 1 |
| Alton, KB; Compton, DS; Davis, HR; Farley, C; Hoos, L; Sybertz, EJ; van Heek, M | 1 |
| Affrime, M; Alton, KB; Cayen, MN; Chowdhury, S; Iannucci, R; Kosoglou, T; Maxwell, SE; Patrick, JE; Statkevich, P; Stauber, KL; Zhu, Y | 1 |
| Achari, R; Burt, DA; Chira, T; Edeki, T; Gustavson, LE; Kelly, MT; Rieser, MJ; Schweitzer, SM; Yannicelli, HD | 1 |
| Basha, SJ; Kumar, NV; Kumar, TR; Mullangi, R; Muzeeb, S; Naveed, SA; Rao, NP; Shashikumar, D; Srinivas, N; Srinivas, NR; Tiwari, NK | 1 |
| Koll, C; Oswald, S; Siegmund, W | 1 |
| de Waart, DR; Kunne, C; Oude Elferink, RP; Schinkel, AH; Vlaming, ML | 1 |
| Lütjohann, D; May, K; Oswald, S; Rosin, J; Siegmund, W | 1 |
| Bae, JW; Choi, CI; Chung, MW; Jang, CG; Lee, JH; Lee, SY | 1 |
| Auge, D; Fahrmayr, C; Fromm, MF; König, J; Mieth, M | 1 |
| Ban, MR; DeGorter, MK; Hegele, RA; Kim, RB; Schwarz, UI; Tirona, RG; Ziada, A | 1 |
| Chiba, T; Kawagishi, H; Kimura, Y; Kioka, N; Matsuo, M; Sakurada, T; Ueda, K; Watanabe, R; Yamaguchi, K | 1 |
| Guo, L; He, M; Jiang, J; Qiu, FR; Wang, MM | 1 |
| Karalis, V; Soulele, K | 1 |
| Kagatani, S; Nakagami, H; Sasagane, Y; Wada, S | 1 |
4 trial(s) available for ezetimibe and sch 60663
| Article | Year |
|---|---|
Disposition of the selective cholesterol absorption inhibitor ezetimibe in healthy male subjects.
Topics: Adult; Anticholesteremic Agents; Area Under Curve; Azetidines; Biotransformation; Chromatography, Liquid; Enterohepatic Circulation; Ezetimibe; Feces; Humans; Male; Mass Spectrometry; Urine | 2002 |
Evaluation of the potential for pharmacokinetic interaction between fenofibrate and ezetimibe: A phase I, open-label, multiple-dose, three-period crossover study in healthy subjects.
Topics: Adult; Azetidines; Cross-Over Studies; Drug Interactions; Drug Therapy, Combination; Ezetimibe; Female; Fenofibrate; Glucuronides; Humans; Hypolipidemic Agents; Male; Middle Aged | 2006 |
Simultaneous determination of ezetimibe and its glucuronide metabolite in human plasma by solid phase extraction and liquid chromatography-tandem mass spectrometry.
Topics: Azetidines; Chromatography, Liquid; Ezetimibe; Glucuronides; Humans; Linear Models; Male; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Tandem Mass Spectrometry | 2015 |
Development of a joint population pharmacokinetic model of ezetimibe and its conjugated metabolite.
Topics: Adult; Azetidines; Drug Compounding; Ezetimibe; Glucuronides; Humans; Hypolipidemic Agents; Models, Biological | 2019 |
14 other study(ies) available for ezetimibe and sch 60663
| Article | Year |
|---|---|
Sugar-substituted 2-azetidinone cholesterol absorption inhibitors: enhanced potency by modification of the sugar.
Topics: Animals; Anticholesteremic Agents; Azetidines; Carbohydrates; Cholesterol; Chromatography, High Pressure Liquid; Cricetinae; Liver; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Structure-Activity Relationship | 1998 |
Synthesis of fluorescent biochemical tools related to the 2-azetidinone class of cholesterol absorption inhibitors.
Topics: Animals; Anticholesteremic Agents; Azetidines; Catalysis; Cholesterol; Drug Design; Ezetimibe; Fluorescent Dyes; Intestinal Absorption; Male; Palladium; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship | 2002 |
Substituted oxazolidinones as novel NPC1L1 ligands for the inhibition of cholesterol absorption.
Topics: Animals; Cholesterol; Intestinal Absorption; Ligands; Membrane Transport Proteins; Microvilli; Oxazolidinones; Rats; X-Ray Diffraction | 2008 |
Molecular mechanism of altered ezetimibe disposition in nonalcoholic steatohepatitis.
Topics: Animals; Anticholesteremic Agents; Azetidines; Bile Acids and Salts; Biliary Tract; Biological Transport; Choline Deficiency; Diet; Ezetimibe; Fatty Liver; Glucuronosyltransferase; Intestinal Mucosa; Liver; Male; Membrane Transport Proteins; Methionine; Multidrug Resistance-Associated Proteins; Non-alcoholic Fatty Liver Disease; Rats; Rats, Sprague-Dawley | 2012 |
Comparison of the activity and disposition of the novel cholesterol absorption inhibitor, SCH58235, and its glucuronide, SCH60663.
Topics: Animals; Anticholesteremic Agents; Autoradiography; Azetidines; Bile; Bile Ducts; Catheterization; Cholesterol; Chromatography, High Pressure Liquid; Ezetimibe; Injections, Intravenous; Intestinal Absorption; Intestines; Male; Rats; Rats, Sprague-Dawley; Time Factors; Tritium | 2000 |
Concurrent determination of ezetimibe and its phase-I and II metabolites by HPLC with UV detection: quantitative application to various in vitro metabolic stability studies and for qualitative estimation in bile.
Topics: Animals; Azetidines; Bile; Chromatography, High Pressure Liquid; Ezetimibe; Glucuronides; Male; Molecular Structure; Rats; Rats, Wistar; Reproducibility of Results; Spectrophotometry, Ultraviolet; Tandem Mass Spectrometry | 2007 |
Disposition of the cholesterol absorption inhibitor ezetimibe in mdr1a/b (-/-) mice.
Topics: Administration, Oral; Animals; Anticholesteremic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Azetidines; Biological Availability; Biotransformation; Cholesterol; Ezetimibe; Feces; Glucuronides; Intestinal Absorption; Kidney; Male; Mice; Mice, Knockout; Tissue Distribution | 2007 |
Complex pharmacokinetic behavior of ezetimibe depends on abcc2, abcc3, and abcg2.
Topics: Administration, Oral; Animals; Anticholesteremic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Azetidines; Biological Transport; Biotransformation; Cell Line; Enterohepatic Circulation; Estradiol; Ezetimibe; Glucuronides; Intestinal Absorption; Intestine, Small; Intubation, Gastrointestinal; Methotrexate; Mice; Mice, Knockout; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Transfection | 2009 |
Synergistic influence of Abcb1 and Abcc2 on disposition and sterol lowering effects of ezetimibe in rats.
Topics: Animals; Anticholesteremic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Azetidines; Cholesterol, Dietary; Cyclosporins; Ezetimibe; Feces; Glucuronides; Male; Metabolic Clearance Rate; Rats; Rats, Inbred Lew; Species Specificity; Sterols; Tissue Distribution | 2010 |
Effects of UDP-glucuronosyltransferase polymorphisms on the pharmacokinetics of ezetimibe in healthy subjects.
Topics: Alleles; Anticholesteremic Agents; Area Under Curve; Azetidines; Ezetimibe; Female; Genotype; Glucuronides; Glucuronosyltransferase; Humans; Intestinal Mucosa; Intestines; Male; Polymorphism, Genetic | 2011 |
Identification of drugs and drug metabolites as substrates of multidrug resistance protein 2 (MRP2) using triple-transfected MDCK-OATP1B1-UGT1A1-MRP2 cells.
Topics: Animals; Azetidines; Cell Line; Dogs; Etoposide; Ezetimibe; Glucuronides; Glucuronosyltransferase; HEK293 Cells; Humans; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organic Anion Transport Protein 1; RNA, Messenger; Transfection | 2012 |
Incremental lowering of low-density lipoprotein cholesterol with ezetimibe 20 mg vs 10 mg daily in patients receiving concomitant statin therapy.
Topics: Aged; Anticholesteremic Agents; Aspartate Aminotransferases; Azetidines; Cholesterol, LDL; Creatine Kinase; Dose-Response Relationship, Drug; Dyslipidemias; Ezetimibe; Female; Glucuronides; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Retrospective Studies | 2013 |
Fomiroid A, a novel compound from the mushroom Fomitopsis nigra, inhibits NPC1L1-mediated cholesterol uptake via a mode of action distinct from that of ezetimibe.
Topics: Anticholesteremic Agents; Azetidines; Binding Sites; Binding, Competitive; Caco-2 Cells; Cholesterol; Coriolaceae; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Esterification; Ezetimibe; Glucuronides; HEK293 Cells; Humans; Lanosterol; Membrane Proteins; Membrane Transport Proteins; Molecular Structure | 2014 |
Bioequivalence Study of Ezetimibe Tablets After a Single Oral Dose of 10 mg in Healthy Japanese Subjects Under Fasting Conditions.
Topics: Administration, Oral; Drugs, Generic; East Asian People; Ezetimibe; Fasting; Healthy Volunteers; Humans; Male; Tablets; Therapeutic Equivalency | 2023 |