Page last updated: 2024-09-04

ezetimibe and ritonavir

ezetimibe has been researched along with ritonavir in 7 studies

Compound Research Comparison

Studies
(ezetimibe)
Trials
(ezetimibe)
Recent Studies (post-2010)
(ezetimibe)
Studies
(ritonavir)
Trials
(ritonavir)
Recent Studies (post-2010) (ritonavir)
2,4845631,4655,4191,2912,772

Protein Interaction Comparison

ProteinTaxonomyezetimibe (IC50)ritonavir (IC50)
Solute carrier organic anion transporter family member 2B1 Homo sapiens (human)6.1
Bile salt export pumpHomo sapiens (human)2.085
ATP-dependent translocase ABCB1Homo sapiens (human)2.65
Cytochrome P450 3A4Homo sapiens (human)0.1623
Cytochrome P450 2D6Homo sapiens (human)2.3
Cytochrome P450 2C9 Homo sapiens (human)2.458
Gag-Pol polyproteinHuman immunodeficiency virus type 1 (NEW YORK-5 ISOLATE)0.067
Substance-K receptorHomo sapiens (human)2.622
UDP-glucuronosyltransferase 1A1 Homo sapiens (human)2.35
Thromboxane-A synthase Homo sapiens (human)0.076
Multidrug and toxin extrusion protein 2Homo sapiens (human)4.4
Multidrug and toxin extrusion protein 1Homo sapiens (human)2.1933
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)4.4
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)2
Protease Human immunodeficiency virus 14.9253

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (14.29)29.6817
2010's5 (71.43)24.3611
2020's1 (14.29)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Chen, S; Chen, Y; Fu, L; Zhang, L1
Gaughan, JP; Klibanov, OM; Tedaldi, EM; van den Berg-Wolf, M1
Blanchet, M; Labonté, P; Sureau, C1

Reviews

2 review(s) available for ezetimibe and ritonavir

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Inhibiting Sodium Taurocholate Cotransporting Polypeptide in HBV-Related Diseases: From Biological Function to Therapeutic Potential.
    Journal of medicinal chemistry, 2022, 10-13, Volume: 65, Issue:19

    Topics: Carcinoma, Hepatocellular; Hep G2 Cells; Hepatitis B; Hepatitis B virus; Hepatocytes; Humans; Interferons; Liver Neoplasms; Nucleotides; Organic Anion Transporters, Sodium-Dependent; Symporters; Virus Internalization

2022

Other Studies

5 other study(ies) available for ezetimibe and ritonavir

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Ezetimibe combined with low-dose statin effectively lowers LDL in protease inhibitor treated patients.
    AIDS patient care and STDs, 2008, Volume: 22, Issue:6

    Topics: Adult; Anticholesteremic Agents; Antiretroviral Therapy, Highly Active; Atorvastatin; Azetidines; Cholesterol, LDL; Drug Administration Schedule; Ezetimibe; Female; Follow-Up Studies; Heptanoic Acids; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Hypercholesterolemia; Lopinavir; Male; Middle Aged; Pilot Projects; Pravastatin; Prospective Studies; Pyrroles; Ritonavir; Treatment Outcome

2008
Use of FDA approved therapeutics with hNTCP metabolic inhibitory properties to impair the HDV lifecycle.
    Antiviral research, 2014, Volume: 106

    Topics: Antiviral Agents; Azetidines; Biphenyl Compounds; Cell Line; Ezetimibe; Hepatitis B virus; Hepatitis Delta Virus; Hepatocytes; Humans; Irbesartan; Organic Anion Transporters, Sodium-Dependent; Receptors, Virus; Ritonavir; Symporters; Tetrazoles; Virus Internalization

2014