Page last updated: 2024-09-04

ezetimibe and orlistat

ezetimibe has been researched along with orlistat in 9 studies

Compound Research Comparison

Studies
(ezetimibe)
Trials
(ezetimibe)
Recent Studies (post-2010)
(ezetimibe)
Studies
(orlistat)
Trials
(orlistat)
Recent Studies (post-2010) (orlistat)
2,4845631,4651,432274539

Protein Interaction Comparison

ProteinTaxonomyezetimibe (IC50)orlistat (IC50)
Phosphatidylserine lipase ABHD16AHomo sapiens (human)0.1
Pancreatic triacylglycerol lipaseSus scrofa (pig)0.4214
Lipoprotein lipaseHomo sapiens (human)0.066
Cytochrome P450 3A4Homo sapiens (human)0.42
Hepatic triacylglycerol lipaseHomo sapiens (human)0.003
Pancreatic triacylglycerol lipaseHomo sapiens (human)0.3253
Translocator proteinRattus norvegicus (Norway rat)1
Cytochrome P450 2C19Homo sapiens (human)0.42
Kappa-type opioid receptorMus musculus (house mouse)0.1903
Fatty acid synthaseHomo sapiens (human)2.99
Fatty-acid amide hydrolase 1Rattus norvegicus (Norway rat)0.01
Platelet-activating factor acetylhydrolaseHomo sapiens (human)0.05
Diacylglycerol lipase-alphaMus musculus (house mouse)0.02
Lysophosphatidylserine lipase ABHD12Homo sapiens (human)0.1682
Diacylglycerol lipase-betaHomo sapiens (human)0.24
Monoacylglycerol lipase ABHD6Homo sapiens (human)0.03
Acyl-protein thioesterase 2Rattus norvegicus (Norway rat)0.17
Diacylglycerol lipase-alphaHomo sapiens (human)0.2677
Endothelial lipaseHomo sapiens (human)0.006

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (44.44)29.6817
2010's4 (44.44)24.3611
2020's1 (11.11)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Song, Z; Wang, X; Xing, D; Xue, J; Zhang, R1
Elisaf, MS; Filippatos, TD; Georgoula, M; Kiortsis, DN; Mikhailidis, DP; Nakou, ES; Tselepis, AD1
Derdemezis, CS; Elisaf, MS; Filippatos, TD; Kiortsis, DN; Mikhailidis, DP; Nakou, ES; Tselepis, AD1
Filippatos, TD; Mikhailidis, DP1
Elisaf, M; Florentin, M; Kostapanos, MS; Liberopoulos, EN; Nakou, ES1
Agouridis, AP; Bairaktari, ET; Elisaf, MS; Filippatos, TD; Kostara, C; Nakou, ES1

Reviews

2 review(s) available for ezetimibe and orlistat

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Lipid-lowering drugs acting at the level of the gastrointestinal tract.
    Current pharmaceutical design, 2009, Volume: 15, Issue:5

    Topics: Animals; Anti-Obesity Agents; Anticholesteremic Agents; Azetidines; Bile Acids and Salts; Clinical Trials as Topic; Ezetimibe; Gastrointestinal Tract; Humans; Lactones; Orlistat; Phytosterols

2009

Trials

4 trial(s) available for ezetimibe and orlistat

ArticleYear
The effect of orlistat and ezetimibe, alone or in combination, on serum LDL and small dense LDL cholesterol levels in overweight and obese patients with hypercholesterolaemia.
    Current medical research and opinion, 2008, Volume: 24, Issue:7

    Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Aged; Anti-Obesity Agents; Anticholesteremic Agents; Azetidines; Body Mass Index; Caloric Restriction; Cholesterol, LDL; Diet, Fat-Restricted; Drug Therapy, Combination; Ezetimibe; Female; gamma-Glutamyltransferase; Homeostasis; Humans; Hypercholesterolemia; Lactones; Male; Middle Aged; Obesity; Orlistat; Overweight; Treatment Outcome; Uric Acid

2008
The effects of ezetimibe and orlistat, alone or in combination, on high-density lipoprotein (HDL) subclasses and HDL-associated enzyme activities in overweight and obese patients with hyperlipidaemia.
    Expert opinion on pharmacotherapy, 2008, Volume: 9, Issue:18

    Topics: Adult; Anti-Obesity Agents; Anticholesteremic Agents; Aryldialkylphosphatase; Azetidines; Body Mass Index; Cholesterol, HDL; Diet, Fat-Restricted; Dose-Response Relationship, Drug; Drug Therapy, Combination; Ezetimibe; Female; Humans; Hyperlipidemias; Lactones; Linear Models; Lipoproteins, HDL2; Lipoproteins, HDL3; Male; Middle Aged; Obesity; Orlistat; Phospholipases A2; Time Factors; Treatment Outcome

2008
Efficacy and safety of ezetimibe plus orlistat or rimonabant in statin-intolerant nondiabetic overweight/obese patients with dyslipidemia.
    Journal of cardiovascular pharmacology and therapeutics, 2009, Volume: 14, Issue:4

    Topics: Anti-Obesity Agents; Anticholesteremic Agents; Azetidines; Body Weight; Drug Therapy, Combination; Dyslipidemias; Ezetimibe; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lactones; Male; Middle Aged; Obesity; Orlistat; Overweight; Piperidines; Pyrazoles; Rimonabant

2009
The effects of ezetimibe and/or orlistat on triglyceride-rich lipoprotein metabolism in obese hypercholesterolemic patients.
    Lipids, 2010, Volume: 45, Issue:5

    Topics: Anti-Obesity Agents; Anticholesteremic Agents; Apolipoprotein C-II; Apolipoprotein C-III; Azetidines; Diet, Fat-Restricted; Drug Therapy, Combination; Ezetimibe; Female; Humans; Lactones; Male; Middle Aged; Obesity; Orlistat; Triglycerides

2010

Other Studies

3 other study(ies) available for ezetimibe and orlistat

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
One-step modification to identify dual-inhibitors targeting both pancreatic triglyceride lipase and Niemann-Pick C1-like 1.
    European journal of medicinal chemistry, 2021, Apr-15, Volume: 216

    Topics: Anticholesteremic Agents; Binding Sites; Cell Line, Tumor; Drug Design; Ezetimibe; Gene Expression Regulation; Humans; Hypercholesterolemia; Lipase; Membrane Transport Proteins; Molecular Docking Simulation; Molecular Dynamics Simulation; Orlistat; Pancreas

2021