ezetimibe has been researched along with methotrexate in 5 studies
Studies (ezetimibe) | Trials (ezetimibe) | Recent Studies (post-2010) (ezetimibe) | Studies (methotrexate) | Trials (methotrexate) | Recent Studies (post-2010) (methotrexate) |
---|---|---|---|---|---|
2,484 | 563 | 1,465 | 41,593 | 5,666 | 11,969 |
Protein | Taxonomy | ezetimibe (IC50) | methotrexate (IC50) |
---|---|---|---|
Thymidylate synthase | Escherichia coli | 1.8 | |
nuclear receptor coactivator 3 isoform a | Homo sapiens (human) | 0.211 | |
Toll-like receptor 4 | Homo sapiens (human) | 1.04 | |
Fatty-acid amide hydrolase 1 | Mus musculus (house mouse) | 0.08 | |
Dihydrofolate reductase | Homo sapiens (human) | 0.0522 | |
Dihydrofolate reductase | Mus musculus (house mouse) | 0.0331 | |
Dihydrofolate reductase | Bos taurus (cattle) | 0.0348 | |
Dihydrofolate reductase | Gallus gallus (chicken) | 0.0545 | |
Dihydrofolate reductase | Enterococcus faecium | 0.0014 | |
Dihydrofolate reductase | Lacticaseibacillus casei | 0.0138 | |
Thymidylate synthase | Homo sapiens (human) | 0.343 | |
5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | 0.0147 | |
Thymidylate synthase | Escherichia coli K-12 | 0.0181 | |
Dihydrofolate reductase | Escherichia coli K-12 | 0.1529 | |
Bifunctional dihydrofolate reductase-thymidylate synthase | Plasmodium falciparum K1 | 0.084 | |
Folate receptor beta | Homo sapiens (human) | 0.1585 | |
5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | 0.0011 | |
Cytochrome P450 11B1, mitochondrial | Bos taurus (cattle) | 0.0012 | |
Folate receptor alpha | Homo sapiens (human) | 0.2263 | |
Dihydrofolate reductase | Pneumocystis carinii | 0.0717 | |
Histidine decarboxylase | Rattus norvegicus (Norway rat) | 0.0014 | |
Trifunctional purine biosynthetic protein adenosine-3 | Homo sapiens (human) | 0.01 | |
Bifunctional purine biosynthesis protein ATIC | Homo sapiens (human) | 0.01 | |
Delta-type opioid receptor | Rattus norvegicus (Norway rat) | 0.003 | |
Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 0.003 | |
Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.003 | |
Reduced folate transporter | Homo sapiens (human) | 0.012 | |
Dihydrofolate reductase | Mycobacterium tuberculosis H37Rv | 0.0174 | |
Folylpolyglutamate synthase, mitochondrial | Homo sapiens (human) | 3.2 | |
Bifunctional dihydrofolate reductase-thymidylate synthase | Toxoplasma gondii | 0.0547 | |
Bifunctional dihydrofolate reductase-thymidylate synthase | Trypanosoma cruzi | 0.11 | |
Dihydrofolate reductase | Bacillus anthracis | 0.0136 | |
Dihydrofolate reductase | Rattus norvegicus (Norway rat) | 0.0047 | |
Proton-coupled folate transporter | Homo sapiens (human) | 0.1207 |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (20.00) | 29.6817 |
2010's | 4 (80.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
de Waart, DR; Kunne, C; Oude Elferink, RP; Schinkel, AH; Vlaming, ML | 1 |
1 review(s) available for ezetimibe and methotrexate
Article | Year |
---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
4 other study(ies) available for ezetimibe and methotrexate
Article | Year |
---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Complex pharmacokinetic behavior of ezetimibe depends on abcc2, abcc3, and abcg2.
Topics: Administration, Oral; Animals; Anticholesteremic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Azetidines; Biological Transport; Biotransformation; Cell Line; Enterohepatic Circulation; Estradiol; Ezetimibe; Glucuronides; Intestinal Absorption; Intestine, Small; Intubation, Gastrointestinal; Methotrexate; Mice; Mice, Knockout; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Transfection | 2009 |