Page last updated: 2024-09-04

ezetimibe and cyclosporine

ezetimibe has been researched along with cyclosporine in 15 studies

Compound Research Comparison

Studies
(ezetimibe)
Trials
(ezetimibe)
Recent Studies (post-2010)
(ezetimibe)
Studies
(cyclosporine)
Trials
(cyclosporine)
Recent Studies (post-2010) (cyclosporine)
2,4845631,4653772170
2,4845631,46530,5473,8026,558

Protein Interaction Comparison

ProteinTaxonomyezetimibe (IC50)cyclosporine (IC50)
ATP-binding cassette sub-family C member 3Homo sapiens (human)0.6315
Bile salt export pumpRattus norvegicus (Norway rat)0.6
Bile salt export pumpHomo sapiens (human)3.5
Interleukin-2Mus musculus (house mouse)0.005
ATP-dependent translocase ABCB1Mus musculus (house mouse)0.7
ATP-dependent translocase ABCB1Homo sapiens (human)1.6792
Cytochrome P450 3A4Homo sapiens (human)3.734
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 25.82
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)9.34
Cytochrome P450 3A5Homo sapiens (human)2.06
ATP-dependent translocase ABCB1Mus musculus (house mouse)4.8
Substance-K receptorHomo sapiens (human)4.139
Peptidyl-prolyl cis-trans isomerase BHomo sapiens (human)0.0088
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)9.34
Cytochrome P450 3A7Homo sapiens (human)2.06
Cytochrome P450 2C19Homo sapiens (human)7
Multidrug resistance-associated protein 1 Homo sapiens (human)3.5082
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)9.34
Peptidyl-prolyl cis-trans isomerase A Homo sapiens (human)0.0252
Peptidyl-prolyl cis-trans isomerase FKBP4Homo sapiens (human)0.016
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoformHomo sapiens (human)0.183
Peptidyl-prolyl cis-trans isomerase DHomo sapiens (human)0.0036
Sodium/bile acid cotransporterHomo sapiens (human)1
Reverse transcriptase/RNaseH Human immunodeficiency virus 10.455
Cytochrome P450 3A43 Homo sapiens (human)2.06
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Mus musculus (house mouse)0.57
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)1.3
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)4.3
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)0.95

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's9 (60.00)29.6817
2010's6 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chang, TK; Ensom, MH; Kiang, TK1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Burton, I; Koshman, SL; Lalonde, LD; Pearson, GJ; Tymchak, WJ1
Ito, MK1
Heemann, U; Kohnle, M; Kribben, A; Philipp, T; Pietruck, F; Witzke, O1
Bergman, AJ; Burke, J; Frick, G; Gottesdiener, K; Greenberg, HE; Johnson-Levonas, AO; Kosoglou, T; Kraft, WK; Larson, P; Murphy, G; Paolini, JF; Reyderman, L; Statkevich, P1
Bergman, AJ; Burke, J; Gottesdiener, K; Johnson-Levonas, AO; Kosoglou, T; Larson, P; Maxwell, SE; Murphy, G; Paolini, JF; Reyderman, L; Robson, R; Statkevich, P1
Barsotti, G; Carpi, A; Consani, C; Manca-Rizza, G; Mantuano, E; Marchetti, V; Panichi, V; Paoletti, S; Sbragia, G; Taccola, D1
Narushima, K; Suzuki, H; Takada, T; Yamanashi, Y1
Baynes, AC; Chaggar, P; Fildes, JE; O'Neill, N; Ritchie, J; Shah, MK; Shaw, SM; Williams, SG; Yonan, N1
Majidi, R; Moghaddasi, S; Nouri-Majalan, N1
Lempp, FA; Urban, S1

Reviews

3 review(s) available for ezetimibe and cyclosporine

ArticleYear
UDP-glucuronosyltransferases and clinical drug-drug interactions.
    Pharmacology & therapeutics, 2005, Volume: 106, Issue:1

    Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic

2005
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Inhibitors of hepatitis B virus attachment and entry.
    Intervirology, 2014, Volume: 57, Issue:3-4

    Topics: Animals; Antibodies, Monoclonal; Antiviral Agents; Azetidines; Cyclosporine; Ezetimibe; Hepatitis B Antibodies; Hepatitis B virus; Hepatocytes; Humans; Immunoglobulins; Lipopeptides; Mice; Organic Anion Transporters, Sodium-Dependent; Symporters; Virus Attachment; Virus Internalization

2014

Trials

4 trial(s) available for ezetimibe and cyclosporine

ArticleYear
Ezetimibe for the treatment of uncontrolled hypercholesterolemia in patients with high-dose statin therapy after renal transplantation.
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2006, Volume: 6, Issue:1

    Topics: Adult; Aged; Anticholesteremic Agents; Azetidines; Cholesterol; Cyclosporine; Drug Therapy, Combination; Ezetimibe; Fatty Acids, Monounsaturated; Female; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Kidney Transplantation; Liver; Male; Middle Aged; Muscle, Skeletal; Pravastatin; Simvastatin; Tacrolimus

2006
Effects of ezetimibe on cyclosporine pharmacokinetics in healthy subjects.
    Journal of clinical pharmacology, 2006, Volume: 46, Issue:3

    Topics: Adult; Anticholesteremic Agents; Area Under Curve; Azetidines; Cross-Over Studies; Cyclosporine; Dose-Response Relationship, Drug; Drug Interactions; Drug Monitoring; Ezetimibe; Female; Humans; Immunosuppressive Agents; Male

2006
Interaction of single-dose ezetimibe and steady-state cyclosporine in renal transplant patients.
    Journal of clinical pharmacology, 2006, Volume: 46, Issue:3

    Topics: Adult; Aged; Anticholesteremic Agents; Area Under Curve; Azetidines; Cyclosporine; Dose-Response Relationship, Drug; Drug Interactions; Drug Monitoring; Ezetimibe; Female; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged

2006
The efficacy and tolerability of ezetimibe in cardiac transplant recipients taking cyclosporin.
    Transplantation, 2009, Mar-15, Volume: 87, Issue:5

    Topics: Adult; Aged; Anticholesteremic Agents; Azetidines; Cholesterol; Cyclosporine; Double-Blind Method; Ezetimibe; Female; Heart Transplantation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunosuppressive Agents; Lipoproteins, LDL; Male; Middle Aged; Placebos; Safety

2009

Other Studies

8 other study(ies) available for ezetimibe and cyclosporine

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Supratherapeutic response to ezetimibe administered with cyclosporine.
    The Annals of pharmacotherapy, 2005, Volume: 39, Issue:9

    Topics: Anticholesteremic Agents; Atorvastatin; Azetidines; Cyclosporine; Drug Interactions; Ezetimibe; Heart Transplantation; Heptanoic Acids; Humans; Hyperlipidemias; Immunosuppressive Agents; Male; Middle Aged; Postoperative Complications; Pyrroles

2005
Comment: supratherapeutic response to ezetimibe administered with cyclosporine.
    The Annals of pharmacotherapy, 2005, Volume: 39, Issue:12

    Topics: Anticholesteremic Agents; Azetidines; Cholesterol, LDL; Cyclosporine; Drug Interactions; Ezetimibe; Humans; Immunosuppressive Agents

2005
Safety and effects on the lipid and C-reactive protein plasma concentration of the association of ezetimibe plus atorvastatin in renal transplant patients treated by cyclosporine-A: a pilot study.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2006, Volume: 60, Issue:5

    Topics: Aged; Anticholesteremic Agents; Atorvastatin; Azetidines; C-Reactive Protein; Cyclosporine; Drug Combinations; Ezetimibe; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunosuppressive Agents; Kidney Function Tests; Kidney Transplantation; Lipids; Male; Middle Aged; Pilot Projects; Pyrroles; Triglycerides

2006
Niemann-pick C1-like 1 mediates alpha-tocopherol transport.
    Molecular pharmacology, 2008, Volume: 74, Issue:1

    Topics: alpha-Tocopherol; Animals; Anticholesteremic Agents; Azetidines; Biological Transport; Caco-2 Cells; Cholesterol; Cyclosporine; Ezetimibe; Humans; Immunohistochemistry; Intestinal Absorption; Male; Membrane Proteins; Membrane Transport Proteins; Micelles; Phosphatidylcholines; Rats; Rats, Wistar; Taurocholic Acid; Temperature; Time Factors; Vitamin A

2008
Impaired kidney allograft function following ezetimibe therapy.
    Iranian journal of kidney diseases, 2011, Volume: 5, Issue:2

    Topics: Anticholesteremic Agents; Azetidines; Creatinine; Cyclosporine; Ezetimibe; Humans; Kidney Transplantation; Male; Middle Aged; Primary Graft Dysfunction

2011