Page last updated: 2024-09-02

exp3174 and avapro

exp3174 has been researched along with avapro in 21 studies

Compound Research Comparison

Studies
(exp3174)
Trials
(exp3174)
Recent Studies (post-2010)
(exp3174)
Studies
(avapro)
Trials
(avapro)
Recent Studies (post-2010) (avapro)
23629431,369385495

Protein Interaction Comparison

ProteinTaxonomyexp3174 (IC50)avapro (IC50)
Bile salt export pumpHomo sapiens (human)7.3067
Type-1 angiotensin II receptorHomo sapiens (human)0.0099
Type-2 angiotensin II receptorHomo sapiens (human)0.003

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (28.57)18.2507
2000's10 (47.62)29.6817
2010's4 (19.05)24.3611
2020's1 (4.76)2.80

Authors

AuthorsStudies
Goldberg, MR; Greenlee, WJ; Irvin, JD; Prendergast, K; Smith, RD; Timmermans, PB; Wexler, RR1
De Backer, JP; Fierens, FL; Fraeyman, N; Vanderheyden, PM; Vauquelin, G1
Schieffer, B; Schmidt, B1
Berellini, G; Cruciani, G; Mannhold, R1
Giridhar, R; Murumkar, P; Naik, P; Yadav, MR1
Fukami, T; Hosomi, H; Iwamura, A; Nakajima, M; Yokoi, T1
Benachour, N; Vanderheyden, PML1
Bauer, JH; Reams, GP1
Abrahamsson, T; Adler, G; Brandt-Eliasson, U; Karp, L; Morsing, P; Ohlson, K; Renberg, L; Sjöquist, PO1
De Backer, JP; Fierens, FL; Vanderheyden, PM; Vauquelin, G1
Coca, A; Giner, V1
Casado, S; Farré, J; Gómez, J; Jiménez, A; López-Blaya, A; López-Farré, A; Montón, M; Núñez, A; Sánchez de Miguel, L; Zalba, LR1
De Backer, JP; Vanderheyden, P; Vauquelin, G; Verheijen, I1
Bessard, G; Caron, F; Cracowski, JL; Hakim, A; Hoffmann, P; Sessa, C; Stanke-Labesque, F1
Dominiak, P; Häuser, W1
Daliani, I; Dimitriou, D; Kamoutsis, C; Kyrikou, I; Laggner, P; Mavromoustakos, T; Pitsas, A; Siapi, E; Zervou, M; Zoga, A; Zoumpoulakis, P1
Avery, MA; Benson, SC; Chittiboyina, A; Desai, P; Ho, CI; Kurtz, TW; Pershadsingh, HA; Pravenec, M; Qi, N; Wang, J1
Ivanova, NA; Preobrazhenskiĭ, DV; Sidorenko, BA; Soplevenko, AV; Stetsenko, TM1
Bähr, IN; Fleck, E; Fritzsche, J; Goebel, M; Gust, R; Hässle, PL; Kappert, K; Kaufmann, J; Kintscher, U; Ott, I; Stawowy, P; Tsuprykov, O; Unger, T1
Arsenault, J; Cabana, J; Escher, E; Guillemette, G; Lanthier, L; Lavigne, P; Leduc, R; Lehoux, J1
Bester, K; Kisielius, V; Li, R; Liang, C; Svendsen, SB1

Reviews

8 review(s) available for exp3174 and avapro

ArticleYear
Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy.
    Journal of medicinal chemistry, 1996, Feb-02, Volume: 39, Issue:3

    Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Humans; Receptors, Angiotensin; Structure-Activity Relationship

1996
Angiotensin II AT1 receptor antagonists. Clinical implications of active metabolites.
    Journal of medicinal chemistry, 2003, Jun-05, Volume: 46, Issue:12

    Topics: Acrylates; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Growth Hormone; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Models, Molecular; Receptor, Angiotensin, Type 1; Tetrazoles; Thiophenes; Thromboxane A2

2003
Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective.
    Bioorganic & medicinal chemistry, 2010, Dec-15, Volume: 18, Issue:24

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Antihypertensive Agents; Humans; Losartan

2010
Influence of the cellular environment on ligand binding kinetics at membrane-bound targets.
    Bioorganic & medicinal chemistry letters, 2017, 08-15, Volume: 27, Issue:16

    Topics: Angiotensin II Type 1 Receptor Blockers; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Humans; Kinetics; Ligands; Protein Binding; Receptor, Angiotensin, Type 1; Receptors, Cell Surface; Signal Transduction

2017
The angiotensin II type 1 receptor antagonists. A new class of antihypertensive drugs.
    Archives of internal medicine, 1995, Jul-10, Volume: 155, Issue:13

    Topics: Acrylates; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Humans; Imidazoles; Irbesartan; Losartan; Pyridines; Quinolines; Telmisartan; Tetrazoles; Thiophenes; Valine; Valsartan

1995
[Antihypertensive advantages of angiotensin II AT1 receptor antagonism].
    Revista espanola de cardiologia, 1999, Volume: 52 Suppl 3

    Topics: Aged; Angiotensin II; Angiotensin Receptor Antagonists; Anti-Arrhythmia Agents; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Clinical Trials as Topic; Heart Diseases; Heart Failure; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan

1999
Efforts to understand the molecular basis of hypertension through drug:membrane interactions.
    Current topics in medicinal chemistry, 2004, Volume: 4, Issue:4

    Topics: Amino Acids; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Binding Sites; Biphenyl Compounds; Calorimetry, Differential Scanning; Cell Membrane; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Magnetic Resonance Spectroscopy; Models, Molecular; Receptor, Angiotensin, Type 1; Tetrazoles; X-Ray Diffraction

2004
[Candesartan - a novel AT(1)-angiotensin receptor blocker: peculiarities of pharmacology and experience of use in arterial hypertension].
    Kardiologiia, 2004, Volume: 44, Issue:1

    Topics: Acrylates; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Diabetic Nephropathies; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Tetrazoles; Thiophenes; Valine; Valsartan

2004

Trials

1 trial(s) available for exp3174 and avapro

ArticleYear
Chronic treatment with losartan results in sufficient serum levels of the metabolite EXP3179 for PPARgamma activation.
    Hypertension (Dallas, Tex. : 1979), 2009, Volume: 54, Issue:4

    Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Benzoates; Biphenyl Compounds; Cell Movement; Dose-Response Relationship, Drug; Female; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Male; Middle Aged; Muscle Cells; PPAR gamma; Telmisartan; Tetrazoles

2009

Other Studies

12 other study(ies) available for exp3174 and avapro

ArticleYear
Distinction between surmountable and insurmountable selective AT1 receptor antagonists by use of CHO-K1 cells expressing human angiotensin II AT1 receptors.
    British journal of pharmacology, 1999, Volume: 126, Issue:4

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Cattle; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Humans; Inositol Phosphates; Receptors, Angiotensin; Recombinant Proteins; Tetrazoles; Transfection

1999
Pharmacophore, drug metabolism, and pharmacokinetics models on non-peptide AT1, AT2, and AT1/AT2 angiotensin II receptor antagonists.
    Journal of medicinal chemistry, 2005, Jun-30, Volume: 48, Issue:13

    Topics: Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Binding Sites; Biphenyl Compounds; Kinetics; Losartan; Models, Molecular; Molecular Conformation; Oxidation-Reduction; Pharmaceutical Preparations; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Structure-Activity Relationship; Tetrazoles

2005
CYP2C9-mediated metabolic activation of losartan detected by a highly sensitive cell-based screening assay.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:5

    Topics: Antihypertensive Agents; Aryl Hydrocarbon Hydroxylases; Benzbromarone; Biotransformation; Cyclooxygenase Inhibitors; Cytochrome P-450 CYP2C9; Diclofenac; HEK293 Cells; Hep G2 Cells; Hepatocytes; Humans; Losartan; NF-E2-Related Factor 2; Semicarbazides; Sensitivity and Specificity; Time Factors; Uricosuric Agents

2011
Mechanistic differences of various AT1-receptor blockers in isolated vessels of different origin.
    Hypertension (Dallas, Tex. : 1979), 1999, Volume: 33, Issue:6

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Blood Proteins; Female; Humans; Imidazoles; In Vitro Techniques; Irbesartan; Kinetics; Losartan; Male; Muscle Contraction; Muscle, Smooth, Vascular; Portal Vein; Rabbits; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Tetrazoles

1999
Insurmountable angiotensin AT1 receptor antagonists: the role of tight antagonist binding.
    European journal of pharmacology, 1999, May-14, Volume: 372, Issue:2

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Binding, Competitive; Biphenyl Compounds; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Humans; Imidazoles; Irbesartan; Losartan; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Recombinant Proteins; Tetrazoles

1999
Comparative effects of angiotensin II AT-1-type receptor antagonists in vitro on human platelet activation.
    Journal of cardiovascular pharmacology, 2000, Volume: 35, Issue:6

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Angiotensin II; Angiotensin Receptor Antagonists; Antibodies, Monoclonal; Benzimidazoles; Benzoates; Binding, Competitive; Biphenyl Compounds; Blood Platelets; Dose-Response Relationship, Drug; Humans; Imidazoles; Irbesartan; Losartan; Platelet Activation; Pyridines; Radioligand Assay; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Telmisartan; Tetrazoles; Thromboxane A2; Time Factors; Valine; Valsartan

2000
A two-state model of antagonist-AT1 receptor interaction: further support by binding studies at low temperature.
    Biochemical pharmacology, 2003, Apr-15, Volume: 65, Issue:8

    Topics: Angiotensin Receptor Antagonists; Animals; Binding Sites; Biphenyl Compounds; CHO Cells; Cold Temperature; Computer Simulation; Cricetinae; Imidazoles; Irbesartan; Kinetics; Losartan; Models, Biological; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Recombinant Proteins; Tetrazoles; Thermodynamics; Transfection

2003
Functional comparison of the antagonistic properties of some Angiotensin II type 1 receptor blockers on the contraction elicited by Angiotensin II and thromboxane A2 on human saphenous veins.
    Journal of cardiovascular pharmacology, 2003, Volume: 42, Issue:1

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Biphenyl Compounds; Drug Antagonism; Humans; Imidazoles; In Vitro Techniques; Irbesartan; Losartan; Muscle Contraction; Muscle, Smooth, Vascular; Receptors, Thromboxane A2, Prostaglandin H2; Saphenous Vein; Tetrazoles; Valine; Valsartan

2003
[Dosage equivalents of AT1-receptor antagonists available in Germany].
    Deutsche medizinische Wochenschrift (1946), 2003, Oct-31, Volume: 128, Issue:44

    Topics: Acrylates; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Clinical Trials as Topic; Germany; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Olmesartan Medoxomil; Placebos; Telmisartan; Tetrazoles; Therapeutic Equivalency; Thiophenes; Time Factors; Valine; Valsartan

2003
Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity.
    Hypertension (Dallas, Tex. : 1979), 2004, Volume: 43, Issue:5

    Topics: Adipocytes; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Benzoates; Biphenyl Compounds; Blood Glucose; Cell Differentiation; Cells, Cultured; Chlorocebus aethiops; Drug Evaluation, Preclinical; Gene Expression Regulation; Imidazoles; Insulin; Irbesartan; Losartan; Male; Mice; Models, Molecular; Myoblasts; Protein Conformation; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Structure-Activity Relationship; Telmisartan; Tetrazoles; Thiazoles; Thiazolidinediones; Thiazolidines; Transcription Factors; Triglycerides; Valine; Valsartan; Weight Gain

2004
A single-nucleotide polymorphism of alanine to threonine at position 163 of the human angiotensin II type 1 receptor impairs Losartan affinity.
    Pharmacogenetics and genomics, 2010, Volume: 20, Issue:6

    Topics: Alanine; Angiotensin II; Animals; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Blood Pressure; Chlorocebus aethiops; COS Cells; Humans; Imidazoles; Inositol Phosphates; Irbesartan; Losartan; Polymorphism, Single Nucleotide; Receptor, Angiotensin, Type 1; Telmisartan; Tetrazoles; Threonine; Valine; Valsartan

2010
Sartan blood pressure regulators in classical and biofilm wastewater treatment - Concentrations and metabolism.
    Water research, 2023, Feb-01, Volume: 229

    Topics: Angiotensin II Type 1 Receptor Blockers; Biofilms; Blood Pressure; Humans; Irbesartan; Losartan; Sewage; Valsartan; Wastewater; Water Pollutants, Chemical; Water Purification

2023