Compounds > exp3174
Page last updated: 2024-09-02

exp3174 and angiotensin ii

exp3174 has been researched along with angiotensin ii in 98 studies

Compound Research Comparison

Studies
(exp3174)		Trials
(exp3174)		Recent Studies (post-2010)
(exp3174)		Studies
(angiotensin ii)		Trials
(angiotensin ii)		Recent Studies (post-2010) (angiotensin ii)
236294338,1521,0897,413

Protein Interaction Comparison

ProteinTaxonomyexp3174 (IC50)angiotensin ii (IC50)
Atrial natriuretic peptide receptor 3Homo sapiens (human)0.002
Type-1A angiotensin II receptor Rattus norvegicus (Norway rat)0.002
Type-1B angiotensin II receptorRattus norvegicus (Norway rat)0.0018
Type-1 angiotensin II receptorHomo sapiens (human)0.0055
Type-2 angiotensin II receptorRattus norvegicus (Norway rat)0.004
Type-2 angiotensin II receptorHomo sapiens (human)0.0011

Research

Studies (98)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's74 (75.51)18.2507
2000's20 (20.41)29.6817
2010's3 (3.06)24.3611
2020's1 (1.02)2.80

Authors

AuthorsStudies
De Backer, JP; Fierens, FL; Fraeyman, N; Vanderheyden, PM; Vauquelin, G1
Alajarín, R; Alvarez-Builla, J; Díez-Marqués, ML; García, G; Griera, M; Rodríguez-Puyol, D; Rodríguez-Puyol, M; Sánchez-Alonso, P; Serrano, I; Vaquero, JJ1
Brunner, HR; Christen, Y; Lee, RJ; Munafo, A; Nussberger, J; Waeber, B1
Brooks, DP; DePalma, PD; Ruffolo, RR1
Chen, SJ; Jin, H; Oparil, S; Wyss, JM; Yang, RH1
Bennett, T; Gardiner, SM; Kemp, PA; Widdop, RE3
Hood, JS; Kadowitz, PJ; Kaye, AD; McMahon, TJ; Minkes, RK; Nossaman, BD1
Biollaz, J; Borland, RM; Brunner, HR; Christen, Y; Lee, RJ; Munafo, A; Nussberger, J; Shum, LY; Waeber, B1
Furtek, CI; Lo, MW1
Entzeroth, M; Mauz, AB; Van Meel, JC; Wienen, W1
Chakravarty, PK; Chang, RS; Clineschmidt, BV; Greenlee, WJ; Lotti, VJ; Mantlo, NB; Patchett, AA; Siegl, PK1
Chakravarty, PK; Chang, RS; Greenlee, WJ; Lotti, VJ; Mantlo, NB; Ondeyka, DL; Patchett, AA; Siegl, PK; Sweet, CS1
Duncia, JV; Hart, SD; Timmermans, PB; Wong, PC1
Carini, DJ; Chiu, AT; Duncia, JV; Johnson, AL; Price, WA; Timmermans, PB; Wells, GJ; Wexler, RR; Wong, PC1
Hart, SD; Timmermans, PB; Wong, PC1
Carini, DJ; Chiu, AT; Duncia, JV; Johnson, AL; Price, WA; Timmermans, PB; Wexler, RR; Wong, PC1
Baker, KM; Conrad, KM; Dostal, DE; Schorb, W; Singer, HA1
Ciccocioppo, R; Cirillo, R; Massi, M; Polidori, C; Pompei, P2
Baker, KM; Bhat, GJ; Conrad, KM; Thekkumkara, TJ; Thomas, WG1
Kunihara, M; Kushida, H; Morita, O1
Baker, KM; Dostal, DE; Du, J; Motel, TJ; Thekkumkara, TJ; Thomas, WG1
Christ, DD1
Berdeaux, A; Giudicelli, JF; Richard, V1
Berman, RS; Bradstreet, DC; Jallard, N; Saenz, A; Sweet, CS; Weidler, DJ1
Guengerich, FP; Jeong, HG; Lee, H; Lee, HS; Rho, JK; Yun, CH1
Fink, GD; Gorbea-Oppliger, VJ1
Fujishima, K; Hachisu, M; Hui, C; Katano, K; Kawano, K; Konno, F; Nagura, J; Ogino, H; Yamamoto, M; Yasuda, S1
Cohen, RB; Delaney, CL; Dickinson, KE; Gu, Z; Moreland, S; Poss, MA; Powell, JR; Ryono, DE; Serafino, RP; Skwish, S1
Bennett, T; Gardiner, SM; Widdop, RE1
Chiu, AT; Keiser, J; Madison, AB; Nishimura, H; Patton, CM; Walker, OE1
Ardaillou, R; Bizet, T; Chansel, D; Levy, B; Pham, P; Vandermeersch, S1
Bensoussan, M; Mitchell, T; Reilly, T; Ronco, PM; Timmermans, PB; Verroust, PJ1
Berdeaux, A; Ghaleh, B; Giudicelli, JF; Richard, V1
Aki, Y; Fukui, T; He, H; Iwao, H; Kimura, S; Miyatake, A; Nishiyama, A; Tamaki, T; Yamamoto, A; Yoshida, H1
Inada, Y; Kohara, Y; Kubo, K; Naka, T; Nishikawa, K; Noda, M; Ojima, M; Sanada, T; Shibouta, Y; Wada, T1
Christian, R; Düsing, R; Ko, Y; Meyer zu Brickwedde, MK; Sachinidis, A; Vetter, H; Weisser, P; Wieczorek, AJ1
Bellan, JA; Kadowitz, PJ; Minkes, RK; Osei, SY1
Nakashima, M; Ohtawa, M; Saitoh, K; Takayama, F; Yoshinaga, T1
Ardaillou, R; Badre, L; Cambar, J; Chansel, D; Czekalski, S; Vandermeersch, S1
Edwards, RM; Stack, EJ; Trizna, W; Weinstock, J1
Li, XC; Widdop, RE1
Dunham, EW; Zhang, X; Zimmerman, BG1
Bosch, SM; Diz, DI; Li, Z; Smith, TL1
Baan, J; Chang, PC; Pfaffendorf, M; van Zwieten, PA; Vermeij, P1
Feng, YH; Husain, A; Karnik, SS; Liu, XP; Noda, K; Saad, Y1
Dunn, FW; Farhadian, F; Hamon, G; Ossart, C; Rappaport, L; Roux, MH; Sabri, K; Samuel, JL1
Caussade, F; Cazes, M; Cloarec, A; Desangle, V; Provost, D; Virone-Oddos, A1
Harada, Y; Hashimoto, Y; Murata, S; Naito, K; Narita, H1
Arendshorst, WJ; Chatziantoniou, C; Kurtz, A; Ruan, X; Wagner, C1
Goldsmith, DJ1
Baker, KM; Conrad, KM; Dostal, DE; Hunt, RA; McWhinney, CD1
Fujimori, A; Inagaki, O; Kusayama, T; Okazaki, T; Satoh, Y; Shibasaki, M; Takanashi, M; Tokioka, T; Uchida, W; Yanagisawa, I1
Bai, SA; Christ, DD; Hellyer, P; Lankford, SM; Plummer, D1
Heller, J; Horácek, V; Kramer, HJ1
Hong, KW; Kim, CD; Lee, SH; Yoo, SE1
Mangiapane, ML; Peters, BR1
Mutschler, E; Palm, D; Soldner, A; Spahn-Langguth, H1
Busse, R; Fisslthaler, B; Fleming, I; Schini-Kerth, VB1
Brosnihan, KB; Ferrario, CM; Li, P1
Freel, RW; Hatch, M; Vaziri, ND1
Carini, DJ; Christ, DD; Duncia, JV; Pierce, ME1
Iouzalen, L; Marche, P; Stepien, O1
Barbe, F; Crozatier, B; Guyene, TT; Hittinger, L; Houël, R; Su, J1
Abrahamsson, T; Adler, G; Brandt-Eliasson, U; Karp, L; Morsing, P; Ohlson, K; Renberg, L; Sjöquist, PO1
De Backer, JP; Fierens, FL; Vanderheyden, PM; Vauquelin, G1
Oberhauser, V; Rump, LC; Schwertfeger, E1
Garcha, RS; Hughes, AD; Sever, PS1
Gould, RJ; Grossman, W; Kusma, SE; Lynch, JJ; Painter, CA; Stump, GL; Thomas, JM; Wallace, AA1
Cheung, PK; Saward, L; Wilson, DP; Zahradka, P1
Hashimoto, Y; Minami, K; Narita, H; Ohashi, R1
Ardaillou, R; Chansel, D; Llorens-Cortes, C; Vandermeersch, S1
Coca, A; Giner, V1
Benet, LZ; Christians, U; Mutschler, E; Soldner, A1
Casado, S; Castilla, C; Farré, J; Gómez, J; Guerra, JI; Jiménez, AM; López-Farré, A; Marcos, P; Montón, M; Núñez, A; Rico, L; Rodríguez-Feo, JA; Sánchez De Miguel, L1
Cervenka, L; Heller, J; Horácek, V; Kramer, HJ; Malý, J1
Casado, S; Farré, J; Gómez, J; Jiménez, A; López-Blaya, A; López-Farré, A; Montón, M; Núñez, A; Sánchez de Miguel, L; Zalba, LR1
Hatta, E; Levi, R; Maruyama, R; Smith, NC; Yasuda, K1
Alova, L; Georgiev, V; Stancheva, S1
Jankowski, J; Schlüter, H; Schmid, A; Tepel, M; van der Giet, M; Zidek, W1
Böger, RH; Drexler, H; Forssmann, WG; Krämer, C; Luchtefeld, M; Schieffer, B; Schmidt, B; Sunkomat, J; Tsikas, D; Walden, M; Witte, J1
Koyama, M; Levi, R; Mackins, CJ; Seyedi, N1
Buczko, W; Kucharewicz, I; Matys, T; Pawlak, D; Pawlak, R1
Edvinsson, L; Malmsjö, M; Pantev, E; Stenman, E; Wackenfors, A1
Chiba, S; Inada, Y; Nakane, T1
Boonstra, PW; Buikema, H; Lübeck, RH; van Buiten, A; van Gilst, WH; van Veldhuisen, DJ; Voors, AA; Wagenaar, LJ1
Bessard, G; Caron, F; Cracowski, JL; Hakim, A; Hoffmann, P; Sessa, C; Stanke-Labesque, F1
Alova, L; Georgiev, V; Stancheva, S; Velkova, M1
Bäcker, A; Heller, J; Horacek, V; Kramer, HJ; Vaneckova, I1
Dominiak, P; Häuser, W1
Arguin, G; Auger-Messier, M; Chaloux, B; Escher, E; Guillemette, G; Leduc, R1
Oberhauser, V; Rump, LC; Sellin, L; Stegbauer, J; Vonend, O1
Auger-Messier, M; Escher, E; Guillemette, G; Leduc, R; Turgeon, ES1
Arsenault, J; Cabana, J; Escher, E; Guillemette, G; Lanthier, L; Lavigne, P; Leduc, R; Lehoux, J1
Breunig, M; Goepferich, A; Haunberger, A; Hennig, R; Ohlmann, A; Pollinger, K; Schweda, F; Staffel, J; Tamm, ER1
Atmuri, NDP; Bernatchez, P; Cait, J; Ciufolini, MA; Donen, G; Dong, Y; Hughes, M; McNagny, KM; Pechkovsky, D; Sauge, E; Sin, DD; Tam, A; Tehrani, AY; Walker, MJA; White, Z; Yuen, C1

Reviews

3 review(s) available for exp3174 and angiotensin ii

ArticleYear
Angiotensin II receptor antagonists. From discovery to antihypertensive drugs.
    Hypertension (Dallas, Tex. : 1979), 1991, Volume: 18, Issue:5 Suppl

    Topics: Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Humans; Imidazoles; Losartan; Receptors, Angiotensin; Tetrazoles

1991
The discovery and development of angiotensin II antagonists.
    Pharmaceutical biotechnology, 1998, Volume: 11

    Topics: Angiotensin II; Animals; Humans; Imidazoles; Losartan; Structure-Activity Relationship; Tetrazoles

1998
[Antihypertensive advantages of angiotensin II AT1 receptor antagonism].
    Revista espanola de cardiologia, 1999, Volume: 52 Suppl 3

    Topics: Aged; Angiotensin II; Angiotensin Receptor Antagonists; Anti-Arrhythmia Agents; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Clinical Trials as Topic; Heart Diseases; Heart Failure; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan

1999

Trials

7 trial(s) available for exp3174 and angiotensin ii

ArticleYear
Clinical experience with angiotensin II receptor antagonists.
    American journal of hypertension, 1992, Volume: 5, Issue:12 Pt 2

    Topics: Administration, Oral; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Humans; Hypertension; Imidazoles; Injections, Intravenous; Losartan; Renin-Angiotensin System; Tetrazoles; Time Factors

1992
Drug concentration response relationships in normal volunteers after oral administration of losartan, an angiotensin II receptor antagonist.
    Clinical pharmacology and therapeutics, 1992, Volume: 51, Issue:5

    Topics: Administration, Oral; Adult; Aldosterone; Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biotransformation; Biphenyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Humans; Imidazoles; Losartan; Male; Reference Values; Renin; Tetrazoles

1992
Pharmacodynamic activity of intravenous E-3174, an angiotensin II antagonist, in patients with essential hypertension.
    American journal of hypertension, 1994, Volume: 7, Issue:12

    Topics: Adult; Aged; Angiotensin II; Antihypertensive Agents; Blood Pressure; Double-Blind Method; Female; Heart Rate; Humans; Hypertension; Imidazoles; Injections, Intravenous; Kidney Function Tests; Losartan; Male; Middle Aged; Renin; Tetrazoles; Uric Acid

1994
Pharmacokinetics and biochemical efficacy after single and multiple oral administration of losartan, an orally active nonpeptide angiotensin II receptor antagonist, in humans.
    British journal of clinical pharmacology, 1993, Volume: 35, Issue:3

    Topics: Administration, Oral; Adult; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Blood Pressure; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Heart Rate; Humans; Imidazoles; Losartan; Male; Middle Aged; Renin; Tetrazoles

1993
Effects of losartan on vasoconstrictor responses to angiotensin II in the forearm vascular bed of healthy volunteers.
    Cardiovascular research, 1996, Volume: 32, Issue:5

    Topics: Administration, Oral; Adult; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Depression, Chemical; Dose-Response Relationship, Drug; Forearm; Humans; Imidazoles; Infusions, Intra-Arterial; Losartan; Male; Plethysmography; Tetrazoles; Vascular Resistance; Vasoconstrictor Agents

1996
A radioreceptor assay for the analysis of AT1-receptor antagonists. Correlation with complementary LC data reveals a potential contribution of active metabolites.
    Journal of pharmaceutical and biomedical analysis, 1998, Volume: 17, Issue:1

    Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Proteins; Chromatography, High Pressure Liquid; Double-Blind Method; Humans; Imidazoles; Losartan; Male; Placebos; Pyrimidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Angiotensin; Reference Values; Sensitivity and Specificity; Tetrazoles

1998
Angiotensin II receptor-independent antiinflammatory and antiaggregatory properties of losartan: role of the active metabolite EXP3179.
    Circulation research, 2002, Apr-19, Volume: 90, Issue:7

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Arachidonic Acid; Biotransformation; Cells, Cultured; Cyclooxygenase 2; Dinoprost; Drug Design; Endothelium, Vascular; Enzyme Activation; Female; Humans; Hypertension; Imidazoles; Inflammation; Intercellular Adhesion Molecule-1; Isoenzymes; Lipopolysaccharides; Losartan; Male; Membrane Proteins; Middle Aged; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; RNA, Messenger; Tetrazoles; Thromboxane A2; Up-Regulation; Vasoconstrictor Agents

2002

Other Studies

88 other study(ies) available for exp3174 and angiotensin ii

ArticleYear
Distinction between surmountable and insurmountable selective AT1 receptor antagonists by use of CHO-K1 cells expressing human angiotensin II AT1 receptors.
    British journal of pharmacology, 1999, Volume: 126, Issue:4

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Cattle; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Humans; Inositol Phosphates; Receptors, Angiotensin; Recombinant Proteins; Tetrazoles; Transfection

1999
New losartan-hydrocaffeic acid hybrids as antihypertensive-antioxidant dual drugs: Ester, amide and amine linkers.
    European journal of medicinal chemistry, 2012, Volume: 50

    Topics: Amides; Amines; Angiotensin II; Animals; Antihypertensive Agents; Antioxidants; Aorta, Thoracic; Caffeic Acids; Cells, Cultured; Esters; Hypertension; Losartan; Male; Molecular Structure; Muscle, Smooth, Vascular; Rats; Rats, Wistar; Structure-Activity Relationship; Vasoconstrictor Agents

2012
Effect of captopril and the nonpeptide angiotensin II antagonists, SK&F 108566 and EXP3174, on renal function in dogs with a renal artery stenosis.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 263, Issue:2

    Topics: Acrylates; Angiotensin II; Animals; Blood Pressure; Captopril; Dogs; Dose-Response Relationship, Drug; Female; Glomerular Filtration Rate; Imidazoles; Inulin; Kidney; Losartan; Regional Blood Flow; Renal Artery Obstruction; Tetrazoles; Thiophenes

1992
Blocking hypothalamic AT1 receptors lowers blood pressure in salt-sensitive rats.
    Hypertension (Dallas, Tex. : 1979), 1992, Volume: 20, Issue:6

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Anterior Hypothalamic Nucleus; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Diet; Heart Rate; Imidazoles; Losartan; Microinjections; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sodium Chloride; Tetrazoles

1992
Inhibition of the haemodynamic effects of angiotensin II in conscious rats by AT2-receptor antagonists given after the AT1-receptor antagonist, EXP 3174.
    British journal of pharmacology, 1992, Volume: 107, Issue:3

    Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Heart Rate; Hemodynamics; Imidazoles; Losartan; Male; Pyridines; Rats; Regional Blood Flow; Tetrazoles

1992
Inhibitory effects of DuP 753 and EXP3174 on responses to angiotensin II in pulmonary vascular bed of the cat.
    Journal of applied physiology (Bethesda, Md. : 1985), 1992, Volume: 73, Issue:5

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Gas Analysis; Cats; Endothelins; Female; Hydrogen-Ion Concentration; Imidazoles; Losartan; Male; Norepinephrine; Pulmonary Circulation; Serotonin; Tetrazoles; Vasopressins

1992
Simultaneous determination of a novel angiotensin II receptor blocking agent, losartan, and its metabolite in human plasma and urine by high-performance liquid chromatography.
    Journal of chromatography, 1992, Jan-17, Volume: 573, Issue:2

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Chromatography, High Pressure Liquid; Humans; Imidazoles; Losartan; Reproducibility of Results; Spectrophotometry, Ultraviolet; Tetrazoles

1992
Different types of receptor interaction of peptide and nonpeptide angiotensin II antagonists revealed by receptor binding and functional studies.
    Molecular pharmacology, 1992, Volume: 41, Issue:6

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Thoracic; Binding Sites; Biphenyl Compounds; Female; Imidazoles; In Vitro Techniques; Iodine Radioisotopes; Kinetics; Losartan; Male; Muscle Contraction; Peptides; Rabbits; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Tetrazoles

1992
In vitro pharmacology of L-158,809, a new highly potent and selective angiotensin II receptor antagonist.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 262, Issue:1

    Topics: Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Binding, Competitive; Biphenyl Compounds; Brain; Cell Membrane; Culture Techniques; Humans; Imidazoles; Losartan; Macaca mulatta; Muscle, Smooth, Vascular; Rabbits; Rats; Species Specificity; Tetrazoles

1992
In vivo pharmacology of L-158,809, a new highly potent and selective nonpeptide angiotensin II receptor antagonist.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 262, Issue:1

    Topics: Administration, Oral; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Female; Imidazoles; Injections, Intravenous; Losartan; Macaca mulatta; Male; Pressoreceptors; Pyridines; Rats; Rats, Inbred Strains; Tetrazoles

1992
Nonpeptide angiotensin II receptor antagonists. Studies with DuP 753 and EXP3174 in dogs.
    European journal of pharmacology, 1991, Sep-24, Volume: 202, Issue:3

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Captopril; Dogs; Female; Furosemide; Imidazoles; Kidney; Kidney Function Tests; Losartan; Male; Pyridines; Radioimmunoassay; Renin-Angiotensin System; Tetrazoles

1991
Effect of angiotensin II antagonism on canine renal sympathetic nerve function.
    Hypertension (Dallas, Tex. : 1979), 1991, Volume: 17, Issue:6 Pt 2

    Topics: Angiotensin II; Animals; Blood Pressure; Captopril; Dogs; Electric Stimulation; Female; Imidazoles; Kidney; Losartan; Male; Norepinephrine; Pyridines; Saralasin; Sympathetic Nervous System; Tetrazoles; Vascular Resistance; Vasoconstriction

1991
Nonpeptide angiotensin II receptor antagonists. XI. Pharmacology of EXP3174: an active metabolite of DuP 753, an orally active antihypertensive agent.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 255, Issue:1

    Topics: Administration, Oral; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Imidazoles; In Vitro Techniques; Losartan; Male; Rabbits; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Tetrazoles

1990
Angiotensin II is a potent stimulator of MAP-kinase activity in neonatal rat cardiac fibroblasts.
    Journal of molecular and cellular cardiology, 1995, Volume: 27, Issue:5

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Newborn; Becaplermin; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cell Division; Cells, Cultured; DNA; Enzyme Activation; Fibroblasts; Heart Ventricles; Imidazoles; Immunoblotting; Losartan; Myocardium; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles

1995
The selective angiotensin AT1 receptor antagonist LR-B/081 potently inhibits drinking induced by central injection of angiotensin II in rats.
    European journal of pharmacology, 1995, Apr-24, Volume: 277, Issue:2-3

    Topics: Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Carbachol; Dose-Response Relationship, Drug; Drinking; Eating; Imidazoles; Injections, Intraventricular; Lethal Dose 50; Losartan; Male; Milk; Pyrimidinones; Rats; Rats, Wistar; Renin-Angiotensin System; Tetrazoles; Thiophenes

1995
Angiotensin II stimulates sis-inducing factor-like DNA binding activity. Evidence that the AT1A receptor activates transcription factor-Stat91 and/or a related protein.
    The Journal of biological chemistry, 1994, Dec-16, Volume: 269, Issue:50

    Topics: Angiotensin II; Animals; Animals, Newborn; Base Sequence; Cells, Cultured; DNA-Binding Proteins; Gene Expression Regulation; Imidazoles; In Vitro Techniques; Losartan; Molecular Sequence Data; Myocardium; Nuclear Proteins; Phosphotyrosine; Promoter Regions, Genetic; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Signal Transduction; STAT1 Transcription Factor; Tetrazoles; Trans-Activators; Transcription Factors; Transcription, Genetic; Tyrosine

1994
Effects of U-97018 on pressor responses to intracerebroventricularly administered angiotensin II in conscious normotensive rats.
    Journal of cardiovascular pharmacology, 1995, Volume: 25, Issue:6

    Topics: Administration, Oral; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension; Imidazoles; Injections, Intravenous; Injections, Intraventricular; Losartan; Male; Pyridazines; Pyridines; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Saralasin; Tetrazoles

1995
Stable expression of a functional rat angiotensin II (AT1A) receptor in CHO-K1 cells: rapid desensitization by angiotensin II.
    Molecular and cellular biochemistry, 1995, May-10, Volume: 146, Issue:1

    Topics: Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Base Sequence; Calcium; Cell Membrane; CHO Cells; Concanavalin A; Cricetinae; Gene Expression; Guanosine Triphosphate; Imidazoles; Losartan; Membrane Potentials; Molecular Sequence Data; Pyridines; Rats; Receptors, Angiotensin; Tetradecanoylphorbol Acetate; Tetrazoles; Transfection; Verapamil

1995
Human plasma protein binding of the angiotensin II receptor antagonist losartan potassium (DuP 753/MK 954) and its pharmacologically active metabolite EXP3174.
    Journal of clinical pharmacology, 1995, Volume: 35, Issue:5

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Blood Proteins; Humans; Imidazoles; Losartan; Protein Binding; Receptors, Angiotensin; Tetrazoles

1995
Central administration of PD 123319 or EXP-3174 inhibits effects of angiotensin II.
    The American journal of physiology, 1993, Volume: 264, Issue:1 Pt 2

    Topics: Angiotensin II; Animals; Brain; Hemodynamics; Imidazoles; Injections, Intraventricular; Losartan; Male; Pyridines; Rats; Rats, Inbred Strains; Substance P; Tetrazoles

1993
Systemic and coronary effects of the angiotensin II receptor antagonist EXP3174 in dogs.
    Journal of cardiovascular pharmacology, 1993, Volume: 22, Issue:1

    Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Coronary Circulation; Dogs; Enalaprilat; Female; Furosemide; Hemodynamics; Imidazoles; Losartan; Male; Renin-Angiotensin System; Tetrazoles

1993
Oxidation of the angiotensin II receptor antagonist losartan (DuP 753) in human liver microsomes. Role of cytochrome P4503A(4) in formation of the active metabolite EXP3174.
    Drug metabolism and disposition: the biological fate of chemicals, 1995, Volume: 23, Issue:2

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzoflavones; Biotransformation; Biphenyl Compounds; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Imidazoles; Losartan; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Receptors, Angiotensin; Tetrazoles

1995
Cerebroventricular injection of angiotensin II antagonist: effects on blood pressure responses to central and systemic angiotensin II.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 273, Issue:2

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Imidazoles; Injections, Intraventricular; Losartan; Male; Microinjections; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles

1995
Pharmacological profile of ME3221, a novel angiotensin II receptor antagonist.
    European journal of pharmacology, 1995, Feb-14, Volume: 274, Issue:1-3

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta, Thoracic; Biphenyl Compounds; Blood Pressure; Bradykinin; Callithrix; Disease Models, Animal; Drug Evaluation; Female; Femoral Artery; Heart Rate; Hypertension, Renal; Imidazoles; Losartan; Male; Rabbits; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Species Specificity; Tetrazoles

1995
BMS-180560, an insurmountable inhibitor of angiotensin II-stimulated responses: comparison with losartan and EXP3174.
    British journal of pharmacology, 1994, Volume: 113, Issue:1

    Topics: Adrenal Cortex; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Extracellular Space; Imidazoles; In Vitro Techniques; Losartan; Male; Membranes; Muscle Contraction; Muscle, Smooth, Vascular; Phosphatidylinositols; Rabbits; Rats; Tetrazoles

1994
Effects of angiotensin II AT1- or AT2-receptor antagonists on drinking evoked by angiotensin II or water deprivation in rats.
    Brain research, 1994, Jun-13, Volume: 648, Issue:1

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Drinking; Heart Rate; Imidazoles; Injections, Intraventricular; Losartan; Male; Pyridines; Rats; Rats, Brattleboro; Tetrazoles; Water Deprivation

1994
Novel angiotensin receptor subtypes in fowl.
    The American journal of physiology, 1994, Volume: 267, Issue:5 Pt 2

    Topics: Acetylcholine; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Abdominal; Biphenyl Compounds; Blood Pressure; Cell Membrane; Chickens; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Imidazoles; In Vitro Techniques; Kinetics; Losartan; Models, Cardiovascular; Muscle Contraction; Muscle, Smooth, Vascular; Pyridines; Receptors, Angiotensin; Reserpine; Tetrazoles

1994
Differential regulation of angiotensin II and losartan binding sites in glomeruli and mesangial cells.
    The American journal of physiology, 1994, Volume: 266, Issue:3 Pt 2

    Topics: Administration, Oral; Angiotensin II; Animals; Binding Sites; Biphenyl Compounds; Glomerular Mesangium; Imidazoles; In Vitro Techniques; Kidney Glomerulus; Losartan; Male; Rats; Rats, Wistar; Receptors, Angiotensin; RNA, Messenger; Saralasin; Tetrazoles

1994
Immunological reactivity of angiotensin II receptor antagonists: possible implications for receptor binding sites.
    European journal of pharmacology, 1993, Oct-15, Volume: 247, Issue:2

    Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antibodies, Monoclonal; Antihypertensive Agents; Biphenyl Compounds; Imidazoles; In Vitro Techniques; Indicators and Reagents; Iodine Radioisotopes; Losartan; Molecular Conformation; Oligopeptides; Pyridines; Rats; Receptors, Angiotensin; Saralasin; Tetrazoles

1993
Comparison of the effects of EXP3174, an angiotensin II antagonist and enalaprilat on myocardial infarct size in anaesthetized dogs.
    British journal of pharmacology, 1993, Volume: 110, Issue:3

    Topics: Anesthesia; Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Coronary Circulation; Disease Models, Animal; Dogs; Enalaprilat; Female; Furosemide; Heart Rate; Imidazoles; Injections, Intravenous; Losartan; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Renin-Angiotensin System; Tetrazoles

1993
Effects of EXP3174, a non-peptide angiotensin II receptor antagonist, on renal hemodynamics and renal function in dogs.
    European journal of pharmacology, 1993, May-12, Volume: 236, Issue:1

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Body Water; Dogs; Glomerular Filtration Rate; Heart Rate; Imidazoles; Infusions, Intra-Arterial; Kidney; Kidney Function Tests; Losartan; Renal Circulation; Sodium; Tetrazoles

1993
Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4- yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (+/-)-1-(cyclohexyloxycarbonyloxy)-ethy
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 266, Issue:1

    Topics: Adrenal Cortex; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cattle; Imidazoles; In Vitro Techniques; Iodine Radioisotopes; Kinetics; Losartan; Male; Muscle Contraction; Muscle, Smooth, Vascular; Prodrugs; Protein Binding; Rabbits; Rats; Rats, Sprague-Dawley; Substrate Specificity; Tetrazoles

1993
Differential blockade of central effects of angiotensin II by AT2-receptor antagonists.
    The American journal of physiology, 1993, Volume: 265, Issue:1 Pt 2

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Brain; Cardiovascular System; Imidazoles; Injections, Intraventricular; Losartan; Male; Pyridines; Rats; Tetrazoles

1993
EXP3174, a metabolite of losartan (MK 954, DuP 753) is more potent than losartan in blocking the angiotensin II-induced responses in vascular smooth muscle cells.
    Journal of hypertension, 1993, Volume: 11, Issue:2

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Cells, Cultured; Female; Imidazoles; In Vitro Techniques; Losartan; Muscle, Smooth, Vascular; Rats; Rats, Inbred WKY; RNA, Messenger; Tetrazoles

1993
Analysis of the inhibitory effects of DuP 753 and EXP 3174 on responses to angiotensin II in the feline hindquarters vascular bed.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 264, Issue:3

    Topics: Angiotensin II; Angiotensin III; Animals; Biphenyl Compounds; Blood Pressure; Cats; Dose-Response Relationship, Drug; Female; Imidazoles; Losartan; Male; Perfusion; Tetrazoles

1993
Intrinsic properties of the nonpeptide angiotensin II antagonist losartan in glomeruli and mesangial cells at high concentrations.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:3

    Topics: Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Calcium; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Glomerular Mesangium; Humans; Imidazoles; Kidney Glomerulus; Losartan; Male; Rats; Rats, Sprague-Dawley; Tetrazoles; Vasoconstrictor Agents

1993
Interaction of nonpeptide angiotensin II receptor antagonists with the urate transporter in rat renal brush-border membranes.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 276, Issue:1

    Topics: Acrylates; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biological Transport; Biphenyl Compounds; Carbon Radioisotopes; Hydrogen-Ion Concentration; Imidazoles; Kidney; Kinetics; Losartan; Male; Microvilli; Naphthalenes; Rats; Rats, Sprague-Dawley; Tetrazoles; Thiophenes; Uric Acid

1996
Angiotensin type 1 receptor antagonists CV-11974 and EXP 3174 cause selective renal vasodilatation in conscious spontaneously hypertensive rats.
    Clinical science (London, England : 1979), 1996, Volume: 91, Issue:2

    Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Imidazoles; Losartan; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renal Circulation; Tetrazoles; Vasodilation

1996
Functional evidence for the ability of angiotensin AT1 receptor antagonists to cross the blood-brain barrier in rats.
    European journal of pharmacology, 1996, Jul-04, Volume: 307, Issue:3

    Topics: Administration, Oral; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Blood-Brain Barrier; Carbachol; Dose-Response Relationship, Drug; Drinking; Imidazoles; Injections, Intraperitoneal; Injections, Intraventricular; Losartan; Male; Nicotinic Acids; Pyrimidinones; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Tetrazoles; Thiophenes

1996
Threshold sodium excretory and renal blood flow effects of angiotensin converting enzyme inhibition.
    Journal of hypertension, 1995, Volume: 13, Issue:12 Pt 1

    Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Differential Threshold; Diuresis; Hemodynamics; Imidazoles; Losartan; Natriuresis; Nephrectomy; Potassium; Ramipril; Rats; Rats, Wistar; Renal Circulation; Tetrazoles; Vasodilation

1995
Interactions of nonpeptide angiotensin II receptor antagonists at imidazoline/guanidinium receptor sites in rat forebrain.
    Journal of cardiovascular pharmacology, 1996, Volume: 28, Issue:3

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Autoradiography; Biphenyl Compounds; Imidazoles; Losartan; Prosencephalon; Rats; Rats, Sprague-Dawley; Tetrazoles

1996
The active state of the AT1 angiotensin receptor is generated by angiotensin II induction.
    Biochemistry, 1996, Dec-24, Volume: 35, Issue:51

    Topics: Amino Acid Sequence; Angiotensin II; Animals; Binding Sites; COS Cells; Imidazoles; Kinetics; Losartan; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Conformation; Protein Structure, Secondary; Rats; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Tetrazoles; Transfection

1996
HR 720, a novel angiotensin receptor antagonist inhibits the angiotensin II-induced trophic effects, fibronectin release and fibronectin-EIIIA+ expression in rat aortic vascular smooth muscle cells in vitro.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 280, Issue:1

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Thoracic; Biphenyl Compounds; Cells, Cultured; Fibronectins; Imidazoles; Leucine; Losartan; Male; Muscle, Smooth, Vascular; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tetrazoles

1997
In vitro and in vivo effects of UP 269-6, a new potent orally active nonpeptide angiotensin II receptor antagonist, on vascular smooth muscle cell proliferation.
    British journal of pharmacology, 1997, Volume: 120, Issue:3

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Carotid Arteries; Carotid Artery Injuries; Catheterization; Cell Division; Imidazoles; In Vitro Techniques; Losartan; Muscle Proteins; Muscle, Smooth, Vascular; Pyrimidines; Rats; Rats, Inbred SHR; Rats, Wistar; Stimulation, Chemical; Tetrazoles

1997
The pharmacologic profile of 606A, a novel angiotensin II receptor antagonist.
    Journal of cardiovascular pharmacology, 1997, Volume: 29, Issue:2

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Cattle; Dogs; Female; Guinea Pigs; Imidazoles; Losartan; Male; Rabbits; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Tetrazoles; Vasoconstriction

1997
Regulation of angiotensin II receptor AT1 subtypes in renal afferent arterioles during chronic changes in sodium diet.
    The Journal of clinical investigation, 1997, Mar-01, Volume: 99, Issue:5

    Topics: Actins; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Biphenyl Compounds; Cloning, Molecular; Culture Techniques; DNA, Complementary; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enalaprilat; Gene Expression Regulation; Imidazoles; Kidney; Losartan; Male; Oligopeptides; Polymerase Chain Reaction; Pyridines; Rats; Rats, Wistar; Receptors, Angiotensin; Renal Artery; Renal Circulation; Ribonucleases; RNA, Messenger; Sodium, Dietary; Tetrazoles; Vasoconstrictor Agents

1997
Angiotensin receptor antagonists.
    Lancet (London, England), 1997, Apr-26, Volume: 349, Issue:9060

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Biphenyl Compounds; Humans; Hypertension; Imidazoles; Losartan; Scleroderma, Systemic; Tetrazoles

1997
The type I angiotensin II receptor couples to Stat1 and Stat3 activation through Jak2 kinase in neonatal rat cardiac myocytes.
    Journal of molecular and cellular cardiology, 1997, Volume: 29, Issue:9

    Topics: Angiotensin II; Animals; Animals, Newborn; Cells, Cultured; DNA-Binding Proteins; Heart; Imidazoles; Janus Kinase 2; Losartan; Myocardium; Nitriles; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; STAT1 Transcription Factor; STAT3 Transcription Factor; Tetrazoles; Trans-Activators; Transcription, Genetic; Tyrosine; Tyrphostins

1997
Pharmacological profile of YM358, a novel nonpeptide angiotensin AT1 receptor antagonist.
    European journal of pharmacology, 1997, Sep-24, Volume: 335, Issue:2-3

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Azoles; Binding, Competitive; Biphenyl Compounds; Blood Pressure; Cattle; Decerebrate State; Imidazoles; In Vitro Techniques; Losartan; Male; Muscle, Smooth, Vascular; Pyridines; Rabbits; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Tetrazoles

1997
Pharmacokinetic-pharmacodynamic relations of losartan and EXP3174 in a porcine animal model.
    Journal of cardiovascular pharmacology, 1997, Volume: 30, Issue:5

    Topics: Angiotensin II; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Area Under Curve; Blood Pressure; Disease Models, Animal; Half-Life; Hypertension; Imidazoles; Infusions, Intravenous; Losartan; Receptors, Angiotensin; Swine; Tetrazoles

1997
Comparative effects of the angiotensin II receptor blocker EXP 3174 and of the angiotensin-converting enzyme inhibitor captopril on renal glomerular hemodynamics in the dog.
    Kidney & blood pressure research, 1997, Volume: 20, Issue:6

    Topics: Adrenergic beta-Antagonists; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Flow Velocity; Blood Pressure; Bradykinin; Captopril; Dogs; Drug Combinations; Female; Glomerular Filtration Rate; Imidazoles; Kidney Glomerulus; Losartan; Male; Potassium; Sodium; Tetrazoles; Urea; Vascular Resistance; Vasodilation; Water

1997
The in vitro pharmacological profile of KR31080, a nonpeptide AT1 receptor antagonist.
    Fundamental & clinical pharmacology, 1998, Volume: 12, Issue:1

    Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Thoracic; Cattle; Cerebellum; Humans; Imidazoles; In Vitro Techniques; Iodine Radioisotopes; Losartan; Membranes; Muscle Contraction; Muscle, Smooth, Vascular; Pyridines; Rabbits; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Recombinant Proteins; Tetrazoles

1998
Role of nitric oxide in responses to renin-angiotensin system inhibition in sodium-depleted guinea pig and rat.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 1998, Volume: 20, Issue:2

    Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Captopril; Dipeptides; Guinea Pigs; Imidazoles; Losartan; Male; Morpholines; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Rats; Rats, Sprague-Dawley; Renin; Renin-Angiotensin System; Sodium; Tetrazoles

1998
Thrombin receptor expression is increased by angiotensin II in cultured and native vascular smooth muscle cells.
    Cardiovascular research, 1998, Volume: 38, Issue:1

    Topics: 6-Ketoprostaglandin F1 alpha; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta; Blotting, Northern; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Imidazoles; In Vitro Techniques; Indoles; Losartan; Male; Muscle Contraction; Muscle, Smooth, Vascular; Polymerase Chain Reaction; Protein Kinase C; Rats; Rats, Wistar; Receptors, Thrombin; RNA, Messenger; Tetrazoles; Thrombin

1998
Losartan inhibits thromboxane A2-induced platelet aggregation and vascular constriction in spontaneously hypertensive rats.
    Journal of cardiovascular pharmacology, 1998, Volume: 32, Issue:2

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Angiotensin II; Animals; Antihypertensive Agents; Aorta; Endothelins; Endothelium, Vascular; Imidazoles; Losartan; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Inbred SHR; Receptors, Prostaglandin; Receptors, Thromboxane A2, Prostaglandin H2; Tetrazoles; Thromboxane A2; Vasoconstriction; Vasoconstrictor Agents

1998
Losartan antagonism of angiotensin-II-induced potassium secretion across rat colon.
    Pflugers Archiv : European journal of physiology, 1998, Volume: 436, Issue:5

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biological Transport; Colon; Dose-Response Relationship, Drug; Drug Antagonism; Extracellular Space; Hydrolysis; Imidazoles; In Vitro Techniques; Losartan; Male; Potassium; Pyridines; Rats; Rats, Sprague-Dawley; Rubidium Radioisotopes; Tetrazoles

1998
Effects of BAY 10-6734 (Embusartan), a new angiotensin II type I receptor antagonist, on vascular smooth muscle cell growth.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:1

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Calcium; Cell Division; Cells, Cultured; Cytosol; Dihydropyridines; DNA; Imidazoles; Losartan; Male; Muscle, Smooth, Vascular; Protein Biosynthesis; Radioligand Assay; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Species Specificity; Tetrazoles

1999
Comparison between angiotensin receptor antagonism and converting enzyme inhibition in heart failure. Differential acute effects according to the renin-angiotensin system activation.
    Basic research in cardiology, 1999, Volume: 94, Issue:2

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Dogs; Enalaprilat; Female; Heart Failure; Hemodynamics; Imidazoles; Losartan; Male; Renin; Renin-Angiotensin System; Tetrazoles; Vasodilation

1999
Mechanistic differences of various AT1-receptor blockers in isolated vessels of different origin.
    Hypertension (Dallas, Tex. : 1979), 1999, Volume: 33, Issue:6

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Blood Proteins; Female; Humans; Imidazoles; In Vitro Techniques; Irbesartan; Kinetics; Losartan; Male; Muscle Contraction; Muscle, Smooth, Vascular; Portal Vein; Rabbits; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Tetrazoles

1999
Insurmountable angiotensin AT1 receptor antagonists: the role of tight antagonist binding.
    European journal of pharmacology, 1999, May-14, Volume: 372, Issue:2

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Binding, Competitive; Biphenyl Compounds; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Humans; Imidazoles; Irbesartan; Losartan; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Recombinant Proteins; Tetrazoles

1999
Interaction of the autonomic nervous and the renin-angiotensin system in heart and kidney.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1999, Volume: 14 Suppl 4

    Topics: Angiotensin II; Autonomic Nervous System; Heart; Humans; Imidazoles; Kidney; Losartan; Norepinephrine; Renin-Angiotensin System; Tetrazoles

1999
Action of AT1 receptor antagonists on angiotensin II-induced tone in human isolated subcutaneous resistance arteries.
    British journal of pharmacology, 1999, Volume: 127, Issue:8

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Arteries; Benzimidazoles; Biphenyl Compounds; Endothelium, Vascular; Humans; Imidazoles; Losartan; Muscle Tonus; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Tetrazoles; Vasoconstrictor Agents

1999
EXP3174, the AII antagonist human metabolite of losartan, but not losartan nor the angiotensin-converting enzyme inhibitor captopril, prevents the development of lethal ischemic ventricular arrhythmias in a canine model of recent myocardial infarction.
    Journal of the American College of Cardiology, 1999, Volume: 34, Issue:3

    Topics: Analysis of Variance; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Captopril; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Female; Heart Ventricles; Humans; Imidazoles; Losartan; Male; Myocardial Infarction; Myocardial Ischemia; Tetrazoles; Time Factors

1999
Angiotensin II receptor antagonists prevent neointimal proliferation in a porcine coronary artery organ culture model.
    Cardiovascular research, 1999, Volume: 42, Issue:3

    Topics: Analysis of Variance; Angioplasty, Balloon, Coronary; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Captopril; Cell Division; Coronary Disease; Coronary Vessels; Culture Techniques; Imidazoles; Losartan; Muscle, Smooth, Vascular; Pyridines; Recurrence; Swine; Tetrazoles

1999
Comparative study of TA-606, a novel angiotensin II receptor antagonist, with losartan in terms of species difference and orthostatic hypotension.
    Japanese journal of pharmacology, 1999, Volume: 81, Issue:1

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Dogs; Dose-Response Relationship, Drug; Hypertension, Renal; Hypotension, Orthostatic; Imidazoles; Losartan; Male; Prodrugs; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Species Specificity; Tetrazoles

1999
Effects of angiotensin II and antagonists on AT(1) receptor expression in mesangial cells.
    European journal of pharmacology, 1999, Nov-19, Volume: 384, Issue:2-3

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Dexamethasone; Dose-Response Relationship, Drug; Gene Expression Regulation; Glomerular Mesangium; Imidazoles; Losartan; Male; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; RNA, Messenger; Tetrazoles

1999
Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and caco-2 cell monolayers.
    British journal of pharmacology, 2000, Volume: 129, Issue:6

    Topics: 2,4-Dinitrophenol; Angiotensin II; Animals; Anti-Arrhythmia Agents; Antimetabolites; Biological Transport, Active; Caco-2 Cells; Cell Line; Chromatography, Liquid; Dogs; Energy Metabolism; Epithelium; Humans; Imidazoles; Kidney; Kinetics; LLC-PK1 Cells; Losartan; Mass Spectrometry; Multidrug Resistance-Associated Protein 2; Swine; Temperature; Tetrazoles

2000
[Effect of losartan on human platelet activation by thromboxane A2].
    Revista espanola de cardiologia, 2000, Volume: 53, Issue:4

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adult; Angiotensin II; Humans; Imidazoles; Losartan; Male; Platelet Activation; Receptors, Thromboxane; Tetrazoles; Thromboxane A2

2000
Effect of intrarenal infusion of angiotensin-(1-7) in the dog.
    Kidney & blood pressure research, 2000, Volume: 23, Issue:2

    Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Diuresis; Dogs; Female; Glomerular Filtration Rate; Imidazoles; Infusions, Intra-Arterial; Kidney; Losartan; Male; Peptide Fragments; Receptors, Angiotensin; Renal Artery; Renal Circulation; Tetrazoles; Urodynamics; Vasodilator Agents

2000
Comparative effects of angiotensin II AT-1-type receptor antagonists in vitro on human platelet activation.
    Journal of cardiovascular pharmacology, 2000, Volume: 35, Issue:6

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Angiotensin II; Angiotensin Receptor Antagonists; Antibodies, Monoclonal; Benzimidazoles; Benzoates; Binding, Competitive; Biphenyl Compounds; Blood Platelets; Dose-Response Relationship, Drug; Humans; Imidazoles; Irbesartan; Losartan; Platelet Activation; Pyridines; Radioligand Assay; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Telmisartan; Tetrazoles; Thromboxane A2; Time Factors; Valine; Valsartan

2000
Angiotensin-converting enzyme-independent angiotensin formation in a human model of myocardial ischemia: modulation of norepinephrine release by angiotensin type 1 and angiotensin type 2 receptors.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 294, Issue:1

    Topics: Aged; Angiotensin II; Chymases; Female; Humans; Imidazoles; Losartan; Male; Middle Aged; Myocardial Ischemia; Norepinephrine; Peptidyl-Dipeptidase A; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Serine Endopeptidases; Tetrazoles

2000
The effects of peptide and nonpeptide angiotensin II-receptor ligands on the activity of brain monoamine oxidase in water-repleted rats.
    Acta physiologica et pharmacologica Bulgarica, 2000, Volume: 25, Issue:2

    Topics: Angiotensin II; Animals; Body Water; Brain; Drinking; Imidazoles; Isoenzymes; Ligands; Losartan; Male; Monoamine Oxidase; Peptides; Rats; Rats, Wistar; Receptors, Angiotensin; Tetrazoles

2000
CoenzymeA glutathione disulfide is a potent modulator of angiotensin II-induced vasoconstriction.
    American journal of hypertension, 2001, Volume: 14, Issue:2

    Topics: Angiotensin II; Animals; Antihypertensive Agents; Coenzyme A; Dose-Response Relationship, Drug; Imidazoles; In Vitro Techniques; Losartan; Male; Perfusion; Rats; Rats, Inbred WKY; Tetrazoles; Time Factors; Vasoconstriction; Vasomotor System

2001
Ischemia promotes renin activation and angiotensin formation in sympathetic nerve terminals isolated from the human heart: contribution to carrier-mediated norepinephrine release.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 302, Issue:2

    Topics: Angiotensin II; Antihypertensive Agents; Female; Heart Atria; Heart Conduction System; Humans; Imidazoles; In Vitro Techniques; Losartan; Male; Middle Aged; Myocardial Ischemia; Norepinephrine; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Renin; Sympathetic Nervous System; Synaptosomes; Tetrazoles

2002
Antithrombotic effect of captopril and losartan is mediated by angiotensin-(1-7).
    Hypertension (Dallas, Tex. : 1979), 2002, Volume: 40, Issue:5

    Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Captopril; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Epoprostenol; Fibrinolytic Agents; Hypertension, Renal; Imidazoles; Infusions, Intravenous; Losartan; Male; Nitric Oxide; Nitric Oxide Synthase; Peptide Fragments; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Tetrazoles; Venous Thrombosis

2002
Comparison of the antagonistic effects of different angiotensin II receptor blockers in human coronary arteries.
    European journal of heart failure, 2002, Volume: 4, Issue:6

    Topics: Adult; Angiotensin II; Angiotensin Receptor Antagonists; Base Sequence; Benzimidazoles; Biphenyl Compounds; Coronary Vessels; Culture Techniques; Dose-Response Relationship, Drug; Female; Humans; Imidazoles; Losartan; Male; Middle Aged; Molecular Sequence Data; Probability; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazoles; Valine; Valsartan; Vasoconstriction

2002
Binding of KRH-594, an antagonist of the angiotensin II type 1 receptor, to cloned human and rat angiotensin II receptors.
    Fundamental & clinical pharmacology, 2002, Volume: 16, Issue:4

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Chlorocebus aethiops; COS Cells; Dose-Response Relationship, Drug; Humans; Imidazoles; In Vitro Techniques; Liver; Losartan; Membranes; Oligopeptides; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Tetrazoles; Thiadiazoles; Time Factors; Transfection

2002
Functional antagonism of different angiotensin II type I receptor blockers in human arteries.
    Cardiovascular drugs and therapy, 2002, Volume: 16, Issue:4

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Benzimidazoles; Biphenyl Compounds; Dose-Response Relationship, Drug; Humans; Imidazoles; In Vitro Techniques; Losartan; Mammary Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Receptor, Angiotensin, Type 1; Tetrazoles; Valine; Valsartan; Vasoconstrictor Agents

2002
Functional comparison of the antagonistic properties of some Angiotensin II type 1 receptor blockers on the contraction elicited by Angiotensin II and thromboxane A2 on human saphenous veins.
    Journal of cardiovascular pharmacology, 2003, Volume: 42, Issue:1

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Biphenyl Compounds; Drug Antagonism; Humans; Imidazoles; In Vitro Techniques; Irbesartan; Losartan; Muscle Contraction; Muscle, Smooth, Vascular; Receptors, Thromboxane A2, Prostaglandin H2; Saphenous Vein; Tetrazoles; Valine; Valsartan

2003
The effects of peptide and nonpeptide antagonists of angiotensin II receptors on the noradrenaline uptake of different brain structures in rats with angiotensin II-induced increase of water intake.
    Acta physiologica et pharmacologica Bulgarica, 2003, Volume: 27, Issue:2-3

    Topics: Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Brain; Drinking Behavior; Imidazoles; Losartan; Male; Norepinephrine; Rats; Rats, Wistar; Saralasin; Tetrazoles

2003
Relative roles of nitric oxide, prostanoids and angiotensin II in the regulation of canine glomerular hemodynamics. A micropuncture study.
    Kidney & blood pressure research, 2004, Volume: 27, Issue:1

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cyclooxygenase Inhibitors; Dogs; Enzyme Inhibitors; Female; Glomerular Filtration Rate; Hemodynamics; Imidazoles; Indomethacin; Kidney Glomerulus; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Prostaglandins; Renal Circulation; Tetrazoles; Time Factors

2004
[Dosage equivalents of AT1-receptor antagonists available in Germany].
    Deutsche medizinische Wochenschrift (1946), 2003, Oct-31, Volume: 128, Issue:44

    Topics: Acrylates; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Clinical Trials as Topic; Germany; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Olmesartan Medoxomil; Placebos; Telmisartan; Tetrazoles; Therapeutic Equivalency; Thiophenes; Time Factors; Valine; Valsartan

2003
Down-regulation of inositol 1,4,5-trisphosphate receptor in cells stably expressing the constitutively active angiotensin II N111G-AT(1) receptor.
    Molecular endocrinology (Baltimore, Md.), 2004, Volume: 18, Issue:12

    Topics: Angiotensin II; Antihypertensive Agents; Calcium; Calcium Channels; Calcium Signaling; Cell Line; Down-Regulation; Embryo, Mammalian; Humans; Imidazoles; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Kidney; Losartan; Receptor, Angiotensin, Type 1; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Tetrazoles; Thapsigargin

2004
Angiotensin II receptor modulation of renal vascular resistance and neurotransmission in young and adult spontaneously hypertensive rats.
    Kidney & blood pressure research, 2005, Volume: 28, Issue:1

    Topics: Aging; Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Imidazoles; Kidney; Losartan; Male; Norepinephrine; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WF; Receptor, Angiotensin, Type 1; Signal Transduction; Sympathetic Nervous System; Tetrazoles; Vascular Resistance; Vasoconstrictor Agents

2005
The constitutively active N111G-AT1 receptor for angiotensin II modifies the morphology and cytoskeletal organization of HEK-293 cells.
    Experimental cell research, 2005, Aug-01, Volume: 308, Issue:1

    Topics: Angiotensin II; Cell Line; Cell Shape; Cytoskeleton; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Losartan; Mutation; Phenotype; Protein Serine-Threonine Kinases; Receptor, Angiotensin, Type 1; rho-Associated Kinases; Tetrazoles

2005
A single-nucleotide polymorphism of alanine to threonine at position 163 of the human angiotensin II type 1 receptor impairs Losartan affinity.
    Pharmacogenetics and genomics, 2010, Volume: 20, Issue:6

    Topics: Alanine; Angiotensin II; Animals; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Blood Pressure; Chlorocebus aethiops; COS Cells; Humans; Imidazoles; Inositol Phosphates; Irbesartan; Losartan; Polymorphism, Single Nucleotide; Receptor, Angiotensin, Type 1; Telmisartan; Tetrazoles; Threonine; Valine; Valsartan

2010
Multivalent nanoparticles bind the retinal and choroidal vasculature.
    Journal of controlled release : official journal of the Controlled Release Society, 2015, Dec-28, Volume: 220, Issue:Pt A

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Binding, Competitive; Calcium Signaling; Capillaries; Choroid; Drug Carriers; HeLa Cells; Humans; Injections, Intravenous; Losartan; Mice; Protein Binding; Quantum Dots; Receptor, Angiotensin, Type 1; Retinal Vessels; Surface Properties; Tissue Distribution

2015
Losartan metabolite EXP3179 is a unique blood pressure-lowering AT1R antagonist with direct, rapid endothelium-dependent vasoactive properties.
    Vascular pharmacology, 2022, Volume: 147

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Endothelium; Imidazoles; Losartan; Mice; Rats; Rats, Inbred SHR; Receptor, Angiotensin, Type 1

2022