exendin-3 and 2--5--dideoxyadenosine

exendin-3 has been researched along with 2--5--dideoxyadenosine* in 1 studies

Other Studies

1 other study(ies) available for exendin-3 and 2--5--dideoxyadenosine

ArticleYear
Presynaptic GLP-1 receptors enhance the depolarization-evoked release of glutamate and GABA in the mouse cortex and hippocampus.
    BioFactors (Oxford, England), 2018, Volume: 44, Issue:2

    Glucagon-like peptide-1 receptors (GLP-1Rs) have been shown to mediate cognitive-enhancing and neuroprotective effects in the central nervous system. However, little is known about their physiological roles on central neurotransmission, especially at the presynaptic level. Using purified synaptosomal preparations and immunofluorescence techniques, here we show for the first time that GLP-1Rs are localized on mouse cortical and hippocampal synaptic boutons, in particular on glutamatergic and GABAergic nerve terminals. Their activation by the selective agonist exendin-4 (1-100 nM) was able to increase the release of either [

    Topics: Adenylyl Cyclases; Animals; Aspartic Acid; Cerebral Cortex; Cyclic AMP; Dideoxyadenosine; Evoked Potentials; Exenatide; gamma-Aminobutyric Acid; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glutamic Acid; Hippocampus; Male; Mice; Mice, Inbred C57BL; Peptides; Presynaptic Terminals; Receptors, Presynaptic; Synaptosomes; Venoms

2018