exendin-(9-39) and dimethyl-succinate

exendin-(9-39) has been researched along with dimethyl-succinate* in 1 studies

Other Studies

1 other study(ies) available for exendin-(9-39) and dimethyl-succinate

Article	Year
Resistance of succinic acid dimethyl ester insulinotropic action to exendin (9-39) amide. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2002, Volume: 34, Issue:1 Exendin (9-39) amide (Ex [9-39]) was recently proposed for use in the treatment of alimentary or reactive hypoglycaemia. It was indeed found to antagonise the insulinotropic action of GLP-1 in rats infused with the dimethyl ester of succinic acid (SAD). We have now investigated whether, under comparable experimental conditions, Ex (9-39) also opposes the insulin-releasing action of SAD itself. Since this was not the case, Ex (9-39) could be safely used to abolish the incretin effect of GLP-1 without interfering with the control of insulin secretion by circulating nutrients. Topics: Animals; Blood Glucose; Insulin; Insulin Secretion; Male; Peptide Fragments; Rats; Rats, Wistar; Succinates	2002

Article

Year

Resistance of succinic acid dimethyl ester insulinotropic action to exendin (9-39) amide.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2002, Volume: 34, Issue:1

Exendin (9-39) amide (Ex [9-39]) was recently proposed for use in the treatment of alimentary or reactive hypoglycaemia. It was indeed found to antagonise the insulinotropic action of GLP-1 in rats infused with the dimethyl ester of succinic acid (SAD). We have now investigated whether, under comparable experimental conditions, Ex (9-39) also opposes the insulin-releasing action of SAD itself. Since this was not the case, Ex (9-39) could be safely used to abolish the incretin effect of GLP-1 without interfering with the control of insulin secretion by circulating nutrients.

Topics: Animals; Blood Glucose; Insulin; Insulin Secretion; Male; Peptide Fragments; Rats; Rats, Wistar; Succinates

2002