ex-527 and peoniflorin

ex-527 has been researched along with peoniflorin* in 1 studies

Other Studies

1 other study(ies) available for ex-527 and peoniflorin

ArticleYear
Paeoniflorin attenuates oxidized low-density lipoprotein-induced apoptosis and adhesion molecule expression by autophagy enhancement in human umbilical vein endothelial cells.
    Journal of cellular biochemistry, 2019, Volume: 120, Issue:6

    Oxidized low-density lipoprotein (ox-LDL)-induced endothelial dysfunction is recognized as a driving force in the development of atherosclerosis (AS). Paeoniflorin (Pae), a typical traditional herbal medicine, possesses anti-inflammatory, antioxidative, antihyperglycaemic, and antiapoptotic properties. Our study aimed to investigate the effects of Pae on ox-LDL-induced injury of the human umbilical vein endothelial cells (HUVECs) and to explore its molecular mechanism. We found that ox-LDL stimulation inhibited cell viability, activated autophagy, and induced apoptosis and adhesion molecule expression in HUVECs. Pae rescued ox-LDL-induced viability reduction and enhanced the ox-LDL-induced autophagy activation in HUVECs. Pae inhibited ox-LDL-induced apoptosis and adhesion molecule expression by autophagy enhancement in HUVECs. In addition, inhibition of SIRT1 by EX-527 abolished the promoting effect of Pae on autophagy and restored the inhibitory effect of Pae on apoptosis and adhesion molecule expression in the presence of ox-LDL. In conclusion, Pae attenuated ox-LDL-induced apoptosis and adhesion molecule expression by autophagy enhancement via upregulation of SIRT1 in HUVECs, shedding light on the mechanism underlying the protective effect of Pae on ox-LDL-induced injury of HUVECs.

    Topics: Antioxidants; Apoptosis; Autophagy; Blood Vessels; Carbazoles; Cell Adhesion Molecules; Cell Survival; Gene Expression Regulation; Glucosides; Human Umbilical Vein Endothelial Cells; Humans; Lipoproteins, LDL; Monoterpenes; Oxidative Stress; Signal Transduction; Sirtuin 1

2019