eupatoriopicrine and cynaropicrin

eupatoriopicrine has been researched along with cynaropicrin* in 1 studies

Other Studies

1 other study(ies) available for eupatoriopicrine and cynaropicrin

Article	Year
Sesquiterpene lactones are potent and irreversible inhibitors of the antibacterial target enzyme MurA. Bioorganic & medicinal chemistry letters, 2006, Nov-01, Volume: 16, Issue:21 We report the identification of the sesquiterpene lactones cnicin and cynaropicrin as potent, irreversible inhibitors of the bacterial enzyme MurA. They covalently bind to the thiol group of Cys115. Judging from the structure-activity relationships, we conclude that the unsaturated ester side chain of cynaropicrin and cnicin is of particular importance for the inhibition of MurA. These results provide evidence that MurA is a target protein of SLs with a probably high relevance for their known antibacterial effect. Topics: Alkyl and Aryl Transferases; Enzyme Inhibitors; Escherichia coli; Lactones; Peptidoglycan; Pseudomonas aeruginosa; Sesquiterpenes; Structure-Activity Relationship	2006

Article

Year

Sesquiterpene lactones are potent and irreversible inhibitors of the antibacterial target enzyme MurA.

Bioorganic & medicinal chemistry letters, 2006, Nov-01, Volume: 16, Issue:21

We report the identification of the sesquiterpene lactones cnicin and cynaropicrin as potent, irreversible inhibitors of the bacterial enzyme MurA. They covalently bind to the thiol group of Cys115. Judging from the structure-activity relationships, we conclude that the unsaturated ester side chain of cynaropicrin and cnicin is of particular importance for the inhibition of MurA. These results provide evidence that MurA is a target protein of SLs with a probably high relevance for their known antibacterial effect.

Topics: Alkyl and Aryl Transferases; Enzyme Inhibitors; Escherichia coli; Lactones; Peptidoglycan; Pseudomonas aeruginosa; Sesquiterpenes; Structure-Activity Relationship

2006