etravirine has been researched along with alpha-naphthoflavone in 5 studies
| Studies (etravirine) | Trials (etravirine) | Recent Studies (post-2010) (etravirine) | Studies (alpha-naphthoflavone) | Trials (alpha-naphthoflavone) | Recent Studies (post-2010) (alpha-naphthoflavone) |
|---|---|---|---|---|---|
| 572 | 90 | 321 | 665 | 1 | 142 |
| Protein | Taxonomy | etravirine (IC50) | alpha-naphthoflavone (IC50) |
|---|---|---|---|
| Carboxylic ester hydrolase | Sus scrofa (pig) | 0.0478 | |
| cGMP-specific 3',5'-cyclic phosphodiesterase | Homo sapiens (human) | 2.3034 | |
| Cytochrome P450 1A1 | Homo sapiens (human) | 0.1921 | |
| Cytochrome P450 1A2 | Homo sapiens (human) | 0.1698 | |
| Aromatase | Homo sapiens (human) | 1.035 | |
| Substance-K receptor | Homo sapiens (human) | 5.8471 | |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | 0.01 | |
| Thromboxane-A synthase | Homo sapiens (human) | 6.7608 | |
| Adenosine receptor A1 | Homo sapiens (human) | 1.1325 | |
| Aryl hydrocarbon receptor | Mus musculus (house mouse) | 0.025 | |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | 0.05 | |
| DNA-dependent protein kinase catalytic subunit | Homo sapiens (human) | 4.98 | |
| Cytochrome P450 1B1 | Homo sapiens (human) | 0.0449 | |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | 1.355 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 4 (80.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, CH; De Clercq, E; Feng, D; Ginex, T; Kang, D; Lee, KH; Liu, X; Luque, FJ; Murugan, NA; Pannecouque, C; Steitz, TA; Wang, Z; Wei, F; Wu, G; Yang, Y; Zhan, P; Zhang, H; Zhang, J; Zhao, T | 1 |
| Arnold, E; De Clercq, E; Fang, Z; Feng, D; Kang, D; Liu, X; Pannecouque, C; Pilch, A; Ruiz, FX; Sun, Y; Wang, Z; Wei, F; Zhan, P; Zhao, T | 1 |
| Chen, FE; De Clercq, E; Ding, L; Pannecouque, C; Zhuang, C | 2 |
| Chen, FE; De Clercq, E; Huang, WJ; Jin, X; Pannecouque, C; Wang, S; Zhang, YX; Zhao, LM | 1 |
5 other study(ies) available for etravirine and alpha-naphthoflavone
| Article | Year |
|---|---|
Identification of Dihydrofuro[3,4- d]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties.
Topics: Animals; Anti-HIV Agents; Binding Sites; Cell Line, Tumor; Furans; HIV Reverse Transcriptase; HIV-1; Humans; Male; Microbial Sensitivity Tests; Molecular Dynamics Simulation; Molecular Structure; Pyrimidines; Rats, Wistar; Reverse Transcriptase Inhibitors; Structure-Activity Relationship | 2019 |
Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel.
Topics: Animals; Anti-HIV Agents; Cell Line; Crystallography, X-Ray; Drug Discovery; ERG1 Potassium Channel; Female; Fluorine; HIV Reverse Transcriptase; HIV-1; Humans; Male; Mice; Microsomes, Liver; Molecular Structure; Protein Binding; Pyrimidines; Rats, Wistar; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Thiophenes | 2020 |
Improving Druggability of Novel Diarylpyrimidine NNRTIs by a Fragment-Based Replacement Strategy: From Biphenyl-DAPYs to Heteroaromatic-Biphenyl-DAPYs.
Topics: Animals; Anti-HIV Agents; Dose-Response Relationship, Drug; Female; HIV Reverse Transcriptase; HIV-1; Humans; Male; Mice; Microbial Sensitivity Tests; Microsomes, Liver; Models, Molecular; Molecular Structure; Pyrimidines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Inhibitors; Structure-Activity Relationship | 2021 |
Discovery of Novel Pyridine-Dimethyl-Phenyl-DAPY Hybrids by Molecular Fusing of Methyl-Pyrimidine-DAPYs and Difluoro-Pyridinyl-DAPYs: Improving the Druggability toward High Inhibitory Activity, Solubility, Safety, and PK.
Topics: Animals; Anti-HIV Agents; Binding Sites; Cell Survival; Cytochrome P-450 Enzyme System; Drug Design; Drug Resistance, Viral; Drug Stability; Female; Half-Life; HIV Reverse Transcriptase; HIV-1; Humans; Mice; Molecular Docking Simulation; Mutation; Pyridines; Pyrimidines; Solubility; Structure-Activity Relationship | 2022 |
Structure-Based Discovery of Novel NH
Topics: Anti-HIV Agents; Biphenyl Compounds; Drug Design; Heterocyclic Compounds, 1-Ring; HIV Reverse Transcriptase; HIV-1; Pyrimidines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship | 2022 |