etorphine has been researched along with morphine in 159 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 83 (52.20) | 18.7374 |
| 1990's | 44 (27.67) | 18.2507 |
| 2000's | 28 (17.61) | 29.6817 |
| 2010's | 4 (2.52) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Portoghese, PS; Takemori, AE | 1 |
| Becketts, K; Bertha, CM; Davis, P; Ellis, M; Flippen-Anderson, JL; Porreca, F; Rice, KC; Rothman, RB; Xu, H | 1 |
| Aceto, MD; Coop, A; Harris, LS; Koch, M; Schmidhammer, H; Schütz, J; Spetea, M | 1 |
| Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y | 1 |
| Keane, PE; Neal, H | 1 |
| Blume, AJ; Finberg, JP; Shorr, J; Spector, S | 1 |
| Braestrup, C; Squires, RF | 1 |
| Blume, AJ | 1 |
| Makman, MH; Walczak, SA; Wilkening, D | 1 |
| Cho, JS; Cho, TM; Loh, HH; Way, EL | 1 |
| Meunier, JC; Zajac, JM | 1 |
| Akera, T; Brody, TM; Davis, ME | 1 |
| Klee, WA; Nirenberg, M; Sharma, SK | 1 |
| Bennett, GJ; Mayer, DJ | 1 |
| Dum, J; Herz, A; Höllt, V; Meyer, G | 1 |
| Bashir, AA; Bramwell, GJ | 1 |
| Jacob, JJ; Ramabadran, K | 1 |
| Macbeath, JT; Moore, BA | 1 |
| Li, CH; Loh, HH; Tseng, LF; Wei, ET | 1 |
| Crain, B; Crain, SM; Peterson, ER; Simon, EJ | 1 |
| Bradley, PB; Briggs, I; Gayton, RJ; Lambert, LA | 1 |
| Cox, BM; Goldstein, A; Opheim, KE; Teschemacher, H | 2 |
| Cho, TM; Harris, RA; Loh, HH; Way, EL; Wu, YC | 1 |
| Bläsig, J; Dum, J; Herz, A; Höllt, V; Schubert, P | 1 |
| Cox, BM; Goldstein, A; Goldstein, JS | 1 |
| Borea, PA; Ongini, E; Trampus, M; Varani, K | 1 |
| Qin, BY; Wang, DX | 1 |
| Kapitsopoulos, G; Makhay, MM; Young, AM | 1 |
| Biswas, R; Maneckjee, R; Vonderhaar, BK | 1 |
| Mosberg, HI; Porreca, F; Qi, JN | 1 |
| Coombes, JE; Pumford, KM; Russell, JA; Sumner, BE | 1 |
| Bonnet, KA; Edmondson, EA; Friedhoff, AJ | 1 |
| Jin, YH; Li, BB; Li, LY; Li, MX; Qiu, ZB; Zhu, CL | 1 |
| Blake, JW; DeQuick, D; Kamerling, S; Tai, C; Tobin, T; Weckman, TJ; Wood, T | 1 |
| Culpepper-Morgan, J; Holt, PR; Kreek, MJ; LaRoche, D; O'Bryan, L; Zhang, J | 1 |
| Cox, BM; McMahon, PN; Werling, LL | 1 |
| Carino, MA; Horita, A; Yamawaki, S | 1 |
| Buder, M; Fuder, H; Riers, HD; Rothacher, G | 1 |
| Livett, BG; Marley, PD | 1 |
| Adler, MW; Geller, EB; Rowan, CH | 1 |
| Bachrach, U; Benalal, D | 1 |
| Cho, TM; Nozaki, M | 1 |
| Costa, T; Gramsch, C; Herz, A; Wüster, M | 1 |
| Nagy, JI; van der Kooy, D | 1 |
| Blank, MS; Catt, KJ; Dufau, ML; Fabbri, A | 1 |
| Coscia, CJ; Devane, WA; Howlett, AC; Spain, JW | 1 |
| Glasel, JA; Pelosi, LA | 1 |
| Dunlap, CE; Leslie, FM | 1 |
| Glavin, GB; Hnatowich, MR; Kiernan, K; Labella, FS | 1 |
| Greenspan, DL; Musacchio, JM | 2 |
| Law, PY; Loh, HH; Tao, PL | 1 |
| Hynes, MD; Leander, JD; Reel, JK; Zimmerman, DM | 1 |
| Braham, E; Brown, D; Leung, MK; Ndubuka, C; Pratt, S; Stefano, GB | 1 |
| Schwartz, JP | 1 |
| Harris, NC; Ryall, RW | 1 |
| Frank, GB; Shetty, SS | 1 |
| Bradford, HF; White, EJ | 1 |
| Fujimoto, JM; Lange, DG; Roerig, SC | 1 |
| Franklin, RB; Fujimoto, JM; Lange, DG; Roerig, SC | 1 |
| Levy, R; Lotem, J; Simantov, R | 1 |
| Clouet, DH; Yonehara, N | 1 |
| Langwiński, R; Matla, J | 1 |
| Day, AR; Freer, RJ; Liao, CS | 1 |
| Paktor, J; Vaught, JL | 1 |
| Contreras, PC; Takemori, AE | 2 |
| Bianchi, G; Fiocchi, R; Manara, L; Peracchia, F; Petrillo, P; Tavani, A | 1 |
| Cochin, J; Miller, JM; Pelikan, EW; Rosow, CE | 1 |
| Field, M; Kachur, JF; Miller, RJ | 1 |
| Kalant, H; Mucha, RF; Volkovskis, C | 1 |
| Herling, S; Medzihradsky, F; Merz, H; Valentino, RJ; Woods, JH | 1 |
| Glasel, JA; Venn, RF | 1 |
| Kurowski, M; Perry, DC; Rosenbaum, JS; Sadée, W | 1 |
| Rothman, RB; Westfall, TC | 1 |
| Ledda, F; Mantelli, L | 1 |
| Tolkovsky, AM | 1 |
| Baram, D; Levy, R; Simantov, R | 1 |
| Brown, DR; Holtzman, SG; Locke, KW | 1 |
| Garzón, J; Lee, NM; Sánchez-Blázquez, P | 1 |
| Bardo, MT; Bhatnagar, RK; Gebhart, GF | 1 |
| Gambino, MC; Petrillo, P; Tavani, A | 1 |
| Aceto, MD; Balster, RL; Gmerek, D; Harris, LS; May, EL; Medzihradsky, F; Slifer, BL; Smith, CB; Winger, GD; Woods, JH | 1 |
| Goldstein, FJ; Malseed, RT; Ossipov, MH | 1 |
| Fujimoto, JM; Petersen, DW | 1 |
| Busse, LW; Fujimoto, JM; Lange, DG; Roerig, SC | 1 |
| Kalant, H; Mucha, RF | 1 |
| Herling, S; Woods, JH | 1 |
| Fuhrman-Lane, C; Fujimoto, JM; Tseng, LF | 1 |
| Clouet, DH; Williams, N | 1 |
| Fujimoto, JM; Lange, DG; Roerig, SC; Wang, RI | 1 |
| Fuhrman-Lane, CL; Fujimoto, JM; Lange, DG; Wang, RI | 1 |
| Duttaroy, A; Yoburn, BC | 1 |
| Davis, T; Duttaroy, A; Shah, S; Yoburn, BC | 2 |
| Jauzac, P; Polastron, J | 1 |
| Nishiyama, N; Schwartz, JP; Taniwaki, T; Wilson, D | 1 |
| House, JD; Makhay, MM; Walker, EA; Young, AM | 1 |
| Crain, SM; Shen, KF | 5 |
| Kaneto, H; Takahashi, M; Tokuyama, S | 1 |
| Billings, B; Duttaroy, A; Yoburn, BC | 1 |
| Chin, H; Kim, DS; Klee, WA | 1 |
| Chu, PC; Evans, CJ; Kang, L; Keith, DE; Lissin, DV; Murray, SR; von Zastrow, M; Zaki, PA | 1 |
| Chang, KJ; Li, LY | 1 |
| Bertolucci, M; De Simoni, MG; Perego, C | 1 |
| Bakogeorgou, E; Castanas, E; Hatzoglou, A | 1 |
| Kaneto, H; Nakamura, F; Nakao, K; Takahashi, M; Tokuyama, S | 1 |
| Kamei, J; Nagase, H; Suzuki, T | 1 |
| Kaneto, H; Nakamura, F; Takahashi, M; Tokuyama, S | 1 |
| Blake, AD; Bot, G; Freeman, JC; Reisine, T | 1 |
| Harris, LS; Kim, SA; Martin, TJ; Smith, JE | 1 |
| Huang, C; Wang, A; Zhang, Q | 1 |
| Ingram, S; McCleskey, EW; Wilding, TJ; Williams, JT | 1 |
| Chen, DH; Miao, H; Qin, BY; Yang, Y | 1 |
| Blake, AD; Bot, G; Li, S; Reisine, T | 1 |
| Bertin, B; Capeyrou, R; Corbani, M; Emorine, LJ; Lepage, JF; Riond, J | 1 |
| Allen, RM; Dykstra, LA; Pitts, RC; Walker, EA | 1 |
| Barak, LS; Bodduluri, SR; Caron, MG; Ferguson, SS; Laporte, SA; Law, PY; Zhang, J | 1 |
| Hairston, CT; Harris, LS; Lutz, PO; Martin, TJ; Porreca, F | 1 |
| Murphy, J; Schulz, K; Schulz, R; Wehmeyer, A | 1 |
| von Zastrow, M; Whistler, JL | 1 |
| Chu, P; Chuang, HH; Jan, LY; von Zastrow, M; Whistler, JL | 1 |
| Akil, H; Lee, KO; Traynor, JR; Woods, JH | 1 |
| Gong, ZH; Liu, JG; Qin, BY | 2 |
| Evans, CJ | 1 |
| Barrett, AC; Bowman, JR; Cook, CD; Picker, MJ; Roach, EL | 1 |
| Benedict Gomes, A; Gallagher, A; Shen, J; Stafford, K; Yoburn, BC | 1 |
| Allen, RM; Dykstra, LA | 1 |
| Fang, L; Kawase, M; Morimoto, Y; Ohmori, S; Saito, S | 1 |
| Commons, KG; Van Bockstaele, EJ | 1 |
| Patel, CN; Patel, MB; Rajashekara, V; Yoburn, BC | 1 |
| Gomes, BA; Patel, C; Patel, M; Rajashekara, V; Yoburn, BC | 1 |
| Sterious, SN; Walker, EA | 1 |
| David Clark, J; Demirci, H; Gharagozlou, P; Lameh, J | 1 |
| France, CR; Gauthier, CR; Gerak, LR | 1 |
| McLaughlin, PJ; Zagon, IS | 1 |
| Aibak, H; Beaudet, A; Cahill, CM; Collier, B; Esdaile, MJ; Kieffer, BL; Morinville, A | 1 |
| Carrigan, KA; Elliott, JC; Lysle, DT; Nelson, CJ; Picker, MJ | 1 |
| Eisinger, DA; Schulz, R | 1 |
| Patel, K; Purohit, V; Yoburn, BC; Zhang, Q | 1 |
| Eisinger, DA; Schulz, R; Wehmeyer, A | 1 |
| Miyatake, M; Nakamura, A; Narita, M; Niikura, K; Suzuki, M; Suzuki, T; Yajima, Y | 1 |
| Grigoriants, OO; Law, PY; Liao, D; Loh, HH | 1 |
| Kumar, P; Pawar, M; Sirohi, S; Sunkaraneni, S; Walker, EA; Yoburn, BC | 1 |
| Chen, C; Chong, PL; Huang, P; Liu-Chen, LY; Unterwald, EM; Xu, W; Yoon, SI | 1 |
| Chu, J; Law, PY; Loh, HH; Qiu, Y; Zheng, H | 1 |
| Arttamangkul, S; Low, MJ; Pintar, J; Quillinan, N; von Zastrow, M; Williams, JT | 1 |
| Benaderet, TS; Bishop-Mathis, K; Dersch, CM; Partilla, JS; Prisinzano, TE; Rothman, RB; Simpson, DS; Wang, X; Xu, H | 1 |
| Ammer, H; Eisinger, DA | 1 |
| Chi, ZQ; Liu, JG; Sun, JF; Tao, YM; Wang, YH; Xu, XJ | 1 |
| Chu, J; Law, PY; Loh, HH; Zhang, Y; Zheng, H | 1 |
| Law, PY; Loh, HH; Zheng, H | 1 |
| Barbier, E; Bi, GH; Chiu, YT; Feng, B; He, Y; Liu-Chen, LY; Wang, JB; Wang, XF; Xi, ZX; Zhan, J; Zhang, HY | 1 |
2 review(s) available for etorphine and morphine
| Article | Year |
|---|---|
Narcotic analgesics, their detection and pain measurement in the horse: a review.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Butorphanol; Chromatography, Thin Layer; Cyclazocine; Ethylketocyclazocine; Etorphine; Fentanyl; Horses; Morphine; Pain Measurement; Pentazocine; Pyrrolidines; Radioimmunoassay; Receptors, Opioid | 1989 |
Biochemical reactions between opiate receptor binding and inhibition of neurotransmission.
Topics: Adenylyl Cyclases; Animals; Brain Chemistry; Calcium; Calmodulin; Etorphine; Humans; Methadone; Molecular Weight; Morphine; Narcotics; Nerve Endings; Nerve Tissue Proteins; Opioid-Related Disorders; Phosphodiesterase Inhibitors; Phosphorylation; Protein Binding; Protein Kinases; Receptors, Opioid; Synaptic Transmission | 1984 |
1 trial(s) available for etorphine and morphine
| Article | Year |
|---|---|
A double-blind clinical trial of the analgesic effects of R & S 218-M, a new potent analgesic for the relief or pain following abdominal surgery: comparison with morphine sulphate.
Topics: Abdomen; Adolescent; Adult; Allyl Compounds; Blood Pressure; Clinical Trials as Topic; Etorphine; Female; Humans; Male; Middle Aged; Morphinans; Morphine; Pain, Postoperative; Pulse; Respiration | 1976 |
156 other study(ies) available for etorphine and morphine
| Article | Year |
|---|---|
Different receptor sites mediate opioid agonism and antagonism.
Topics: Animals; Binding Sites; Kinetics; Naltrexone; Narcotic Antagonists; Narcotics; Receptors, Opioid; Structure-Activity Relationship | 1983 |
Probes for narcotic receptor-mediated phenomena. 21. Novel derivatives of 3-(1,2,3,4,5,11-hexahydro-3-methyl-2,6-methano-6H-azocino[4,5-b]indol- 6-yl)-phenols with improved delta opioid receptor selectivity.
Topics: Analgesics; Animals; Crystallography, X-Ray; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Molecular Probes; Phenols; Radioligand Assay; Receptors, Opioid, delta; Stereoisomerism; Vas Deferens | 1996 |
Synthesis and biological evaluation of 14-alkoxymorphinans. 20. 14-phenylpropoxymetopon: an extremely powerful analgesic.
Topics: Analgesics, Opioid; Animals; Etorphine; Guinea Pigs; Male; Mice; Mice, Inbred ICR; Morphinans; Morphine; Morpholines; Nociceptors; Pain Measurement; Radioligand Assay; Rats; Reaction Time; Receptors, Opioid; Structure-Activity Relationship | 2003 |
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption | 2007 |
The effects of local micro injections of opiates and enkephalins into the forebrain on the electrocorticogram of the rat.
Topics: Animals; Brain; Codeine; Electroencephalography; Endorphins; Enkephalins; Etorphine; Male; Morphinans; Morphine; Naloxone; Rats; Receptors, Dopamine; Thebaine | 1978 |
Binding of the endogenous nonpeptide morphine-like compound to opiate receptors.
Topics: Animals; Binding, Competitive; Brain Chemistry; Cattle; Cell Line; Cell Membrane; Enkephalins; Etorphine; Humans; In Vitro Techniques; Morphine; Naloxone; Narcotics; Radioimmunoassay; Receptors, Opioid | 1977 |
Characteristics and regional distributions of two distinct [3H]naloxone binding sites in the rat brain.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Cyclazocine; Diprenorphine; Etorphine; In Vitro Techniques; Male; Morphine; Nalorphine; Naloxone; Organ Specificity; Rats; Receptors, Opioid; Temperature | 1978 |
Interaction of ligands with the opiate receptors of brain membranes: regulation by ions and nucleotides.
Topics: Animals; Brain; Enkephalins; Etorphine; Guanylyl Imidodiphosphate; Ligands; Male; Manganese; Morphine; Morphine Derivatives; Naltrexone; Rats; Receptors, Opioid; Ribonucleotides; Sodium | 1978 |
Interaction of morphine, etorphine and enkephalins with dopamine-stimulated adenylate cyclase of monkey amygdala.
Topics: Adenylyl Cyclases; Amygdala; Animals; Dopamine; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Etorphine; Freezing; Haplorhini; Macaca mulatta; Morphinans; Morphine; Naloxone; Receptors, Opioid; Stimulation, Chemical | 1979 |
Narcotic binding to membrane acidic lipids.
Topics: Animals; Cerebrosides; Chemical Phenomena; Chemistry; Etorphine; Levorphanol; Membrane Lipids; Models, Biological; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Receptors, Opioid; Stereoisomerism | 1979 |
Cerebellar opiate receptors in lagomorphs. Demonstration, characterization and regional distribution.
Topics: Animals; Brain Mapping; Cerebellar Cortex; Cerebellum; Cricetinae; Dextrorphan; Enkephalins; Etorphine; Female; Levorphanol; Male; Mice; Morphine; Naloxone; Rabbits; Rats; Receptors, Opioid; Species Specificity | 1979 |
Reduction of opiate binding to brainstem slices associated with the development of tolerance to morphine in rats.
Topics: Analgesics; Animals; Binding, Competitive; Brain Stem; Etorphine; Humans; In Vitro Techniques; Male; Morphine; Morphine Dependence; Naloxone; Rats; Receptors, Opioid; Sodium; Time Factors | 1979 |
Opiate-dependent modulation of adenylate cyclase.
Topics: Adenosine; Adenylyl Cyclases; Cell Line; Cycloheximide; Enzyme Activation; Etorphine; Fluorides; Glioma; Guanylyl Imidodiphosphate; Hybrid Cells; Kinetics; Morphinans; Morphine; Naloxone; Neuroblastoma; Prostaglandins E | 1977 |
Inhibition of spinal cord interneurons by narcotic microinjection and focal electrical stimulation in the periaqueductal central gray matter.
Topics: Animals; Cerebral Aqueduct; Electric Stimulation; Etorphine; Evoked Potentials; Interneurons; Male; Mechanoreceptors; Morphine; Naloxone; Neural Inhibition; Neural Pathways; Nociceptors; Rats; Reflex; Spinal Cord; Tail | 1979 |
In vivo opiate binding unchanged in tolerant/dependent mice.
Topics: Animals; Binding, Competitive; Cerebellum; Drug Tolerance; Etorphine; Humans; Mice; Morphine; Morphine Dependence; Naloxone; Narcotics; Substance Withdrawal Syndrome; Time Factors | 1979 |
Effect of etorphine on brain stem neurones in the rat: a microiontophoretic study [proceedings].
Topics: Animals; Brain Stem; Etorphine; In Vitro Techniques; Iontophoresis; Male; Morphinans; Morphine; Neurons; Rats | 1977 |
Enhancement of a nociceptive reaction by opioid antagonists in mice.
Topics: Animals; Buprenorphine; Etorphine; Male; Mice; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; Pain; Stereoisomerism | 1978 |
Comparison of the behavioral effects of beta-endorphin and enkephalin analogs.
Topics: Animals; Behavior, Animal; Endorphins; Enkephalins; Etorphine; Male; Mice; Morphine; Motor Activity; Naloxone; Oligopeptides; Peptides; Rats | 1977 |
Selective opiate depression of sensory-evoked synaptic networks in dorsal horn regions of spinal cord cultures.
Topics: Animals; Dextrorphan; Etorphine; Evoked Potentials; Levorphanol; Mice; Morphine; Naloxone; Organ Culture Techniques; Reaction Time; Spinal Cord; Synapses | 1977 |
Effects of microiontophoretically applied methionine-enkephalin on single neurones in rat brain.
Topics: Action Potentials; Animals; Brain Stem; Etorphine; Ligands; Morphine; Nerve Tissue Proteins; Neurons; Oligopeptides; Rats; Receptors, Drug | 1976 |
A peptide-like substance from pituitary that acts like morphine. 2. Purification and properties.
Topics: Animals; Binding, Competitive; Biological Assay; Brain; Carboxypeptidases; Cattle; Chromatography, Ion Exchange; Chymotrypsin; Etorphine; Guinea Pigs; Ileum; Molecular Weight; Morphine; Morphine Derivatives; Naloxone; Peptides; Pituitary Gland; Receptors, Drug; Sodium; Swine; Trypsin | 1975 |
Opiate binding to cerebroside sulfate: a model system for opiate-receptor interaction.
Topics: Animals; Cerebrosides; Etorphine; Levorphanol; Liposomes; Mice; Mice, Inbred CBA; Mice, Inbred ICR; Models, Biological; Morphinans; Morphine; Mutation; Receptors, Drug; Structure-Activity Relationship; Sulfoglycosphingolipids | 1975 |
A peptide-like substance from pituitary that acts like morphine. I. Isolation.
Topics: Animals; Binding, Competitive; Biological Assay; Brain; Cattle; Etorphine; Ileum; Male; Morphine; Naloxone; Peptides; Pituitary Gland; Receptors, Drug; Sodium; Vas Deferens | 1975 |
Comparison of in vivo and in vitro parameters of opiate receptor binding in naive and tolerant dependent rodents.
Topics: Animals; Autoradiography; Brain; Cyclopropanes; Drug Tolerance; Etorphine; Humans; Levallorphan; Mice; Morphine; Naloxone; Opium; Pain; Rats; Receptors, Drug; Stereoisomerism; Structure-Activity Relationship; Substance Withdrawal Syndrome; Substance-Related Disorders | 1975 |
A synthetic peptide with morphine-like pharmacologic action.
Topics: Animals; Binding, Competitive; Etorphine; In Vitro Techniques; Levorphanol; Mice; Models, Structural; Morphine; Neuromuscular Junction; Oligopeptides; Receptors, Drug; Structure-Activity Relationship | 1975 |
The neutral endopeptidase-24.11 inhibitor SCH 34826 does not change opioid binding but reduces D1 dopamine receptors in rat brain.
Topics: Analgesics; Animals; Brain Chemistry; Dioxolanes; Dipeptides; Dopamine Antagonists; Enkephalin, Leucine-2-Alanine; Etorphine; Kinetics; Male; Morphine; Neprilysin; Rats; Rats, Inbred Strains; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Receptors, sigma | 1991 |
[Effect of dihydroetorphine on contraction response of guinea pig ileum, mouse, and rabbit vas deferens induced by electric field stimulation in vitro].
Topics: Analgesics, Opioid; Animals; Etorphine; Guinea Pigs; Ileum; Male; Mice; Morphine; Muscle Contraction; Naloxone; Narcotics; Rabbits; Vas Deferens | 1991 |
Tolerance to morphine-like stimulus effects of mu opioid agonists.
Topics: Animals; Buprenorphine; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Tolerance; Etorphine; Male; Methadone; Morphine; Rats; Rats, Inbred Strains | 1991 |
Binding of opioids to human MCF-7 breast cancer cells and their effects on growth.
Topics: Breast Neoplasms; Cell Division; Cell Line; Cell Membrane; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Estradiol; Etorphine; Female; Humans; Kinetics; Morphinans; Morphine; Receptors, Opioid; Tumor Cells, Cultured | 1990 |
Modulation of the potency and efficacy of mu-mediated antinociception by delta agonists in the mouse.
Topics: Analgesics; Animals; Codeine; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphinans; Morphine; Pain Measurement; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1990 |
Opioid receptor subtypes in the supraoptic nucleus and posterior pituitary gland of morphine-tolerant rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Autoradiography; Benzomorphans; Binding, Competitive; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; Female; Injections, Intraventricular; Morphine; Pituitary Gland, Posterior; Plasma; Preoptic Area; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Supraoptic Nucleus | 1990 |
The effect of hyperthyroidism on opiate receptor binding and pain sensitivity.
Topics: Animals; Brain; Etorphine; Hyperthyroidism; Ligands; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Pain; Receptors, Opioid; Thyroxine | 1990 |
Pharmacological study of an irreversible partial agonist of opiate receptors, A-alpha-CAO.
Topics: Analgesia; Animals; Etorphine; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Rabbits; Rats; Rats, Inbred Strains; Receptors, Opioid; Thebaine; Vas Deferens | 1989 |
Orally administered kappa as well as mu opiate agonists delay gastrointestinal transit time in the guinea pig.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Administration, Oral; Animals; Etorphine; Gastrointestinal Motility; Guinea Pigs; Male; Methadone; Morphine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1988 |
Selective tolerance at mu and kappa opioid receptors modulating norepinephrine release in guinea pig cortex.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cerebral Cortex; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Guinea Pigs; Male; Morphine; Norepinephrine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1988 |
Analeptic effect of opiate receptor agonists in rabbits.
Topics: Animals; Arousal; Brain; Central Nervous System Stimulants; Codeine; Cyclazocine; Dose-Response Relationship, Drug; Enkephalin, Methionine; Ethylketocyclazocine; Etorphine; Male; Meperidine; Methadone; Morphine; Naltrexone; Narcotics; Phenazocine; Rabbits; Receptors, Opioid; Reflex | 1985 |
On the opioid receptor subtype inhibiting the evoked release of 3H-noradrenaline from guinea-pig atria in vitro.
Topics: Animals; Atropine; Benzomorphans; Binding, Competitive; Corticosterone; Cyclazocine; Desipramine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Guinea Pigs; Heart Atria; In Vitro Techniques; Morphine; Myocardium; Naloxone; Norepinephrine; Peptide Fragments; Phentolamine; Receptors, Opioid; Receptors, Opioid, kappa; Synapses | 1986 |
Effects of opioid compounds on desensitization of the nicotinic response of isolated bovine adrenal chromaffin cells.
Topics: Adrenal Medulla; Animals; Calcium; Cattle; Cells, Cultured; Chromaffin System; Diprenorphine; Drug Tolerance; Dynorphins; Endorphins; Enkephalin, Methionine; Epinephrine; Etorphine; Morphine; Naloxone; Nicotine; Norepinephrine; Peptide Fragments; Potassium | 1987 |
Body temperature effects of opioids in rats: intracerebroventricular administration.
Topics: Animals; beta-Endorphin; Body Temperature; Cyclazocine; Dose-Response Relationship, Drug; Endorphins; Ethylketocyclazocine; Etorphine; Heroin; Injections, Intraventricular; Injections, Subcutaneous; Male; Morphine; Naloxone; Narcotics; Pentazocine; Phenazocine; Rats; Rats, Inbred Strains | 1986 |
Opiates and cultured neuroblastoma x glioma cells. Effect on cyclic AMP and polyamine levels and on ornithine decarboxylase and protein kinase activities.
Topics: Cell Line; Cyclic AMP; Etorphine; Glioma; Morphine; Narcotics; Neuroblastoma; Ornithine Decarboxylase; Polyamines; Protein Kinases | 1985 |
Effects of 5,5'-dithiobis-(2-nitrobenzoic acid) on opiate binding to both the membrane-bound receptor and the partially purified opiate receptor.
Topics: Animals; Butorphanol; Cell Membrane; Dihydromorphine; Diprenorphine; Dithionitrobenzoic Acid; Dithiothreitol; Etorphine; Morphine; Nalorphine; Naloxone; Naltrexone; Nitrobenzoates; Oxymorphone; Rats; Receptors, Opioid | 1985 |
Multiple states of opioid receptors may modulate adenylate cyclase in intact neuroblastoma X glioma hybrid cells.
Topics: Adenylyl Cyclases; Animals; Cell Line; Cyclic AMP; Diprenorphine; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Glioma; Hybrid Cells; Kinetics; Ligands; Morphine; Naloxone; Neuroblastoma; Neurons; Receptors, Opioid; Receptors, Opioid, delta | 1985 |
Hyperalgesia mediated by peripheral opiate receptors in the rat.
Topics: Administration, Topical; Animals; Behavior, Animal; Capsaicin; Etorphine; Hyperalgesia; Hyperesthesia; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine; Naloxone; Neurons, Afferent; Rats; Rats, Inbred Strains; Receptors, Opioid | 1985 |
Inhibition of luteinizing hormone release by morphine and endogenous opiates in cultured pituitary cells.
Topics: Animals; beta-Endorphin; Cells, Cultured; Endorphins; Etorphine; Female; Gonadotropin-Releasing Hormone; Immunologic Techniques; Luteinizing Hormone; Morphine; Naltrexone; Pituitary Gland, Anterior; Rats; Receptors, Cell Surface; Receptors, LHRH; Receptors, Opioid | 1986 |
An assessment of the role of opioid receptors in the response to cannabimimetic drugs.
Topics: Adenylyl Cyclase Inhibitors; Animals; Cannabinoids; Cell Line; Dronabinol; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Etorphine; Morphine; Naltrexone; Neuroblastoma; Neurons; Receptors, Opioid; Receptors, Opioid, delta | 1986 |
Morphine-mimetic anti-paratypic antibodies: cross-reactive properties.
Topics: Animals; Antibodies, Monoclonal; Binding, Competitive; Chromatography, Affinity; Cross Reactions; Etorphine; Immunoglobulin Fab Fragments; Immunoglobulin Idiotypes; Mice; Morphine; Naloxone; Rabbits; Receptors, Opioid | 1986 |
Effect of ascorbate on the toxicity of morphine in mice.
Topics: Analgesia; Animals; Ascorbic Acid; Brain Chemistry; Dihydromorphine; Etorphine; Male; Mice; Morphine; Pentobarbital; Receptors, Opioid; Sleep | 1985 |
Cold-restraint stress reduces [3H]etorphine binding to rat brain membranes: influence of acute and chronic morphine and naloxone.
Topics: Animals; Brain; Cell Membrane; Cold Temperature; Etorphine; Kinetics; Male; Morphinans; Morphine; Naloxone; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid; Stress, Physiological | 1986 |
The adenylate cyclase rebound response to naloxone in the NG108-15 cells. Effects of etorphine and other opiates.
Topics: Adenylyl Cyclases; Alprostadil; Cell Line; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Etorphine; Glioma; Morphinans; Morphine; Naloxone; Neuroblastoma; Receptors, Opioid | 1986 |
Decrease in delta and mu opioid receptor binding capacity in rat brain after chronic etorphine treatment.
Topics: Animals; Brain; Cell Membrane; Etorphine; Kinetics; Morphinans; Morphine; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tissue Distribution | 1987 |
Use of beta-funaltrexamine to determine mu opioid receptor involvement in the analgesic activity of various opioid ligands.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Biological Assay; Buprenorphine; Butorphanol; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Etorphine; Fentanyl; Methadone; Mice; Morphine; Muscle Contraction; Nalbuphine; Nalorphine; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, mu | 1987 |
Opiates stimulate food consumption in the land snail Helix aspersa.
Topics: Animals; Dose-Response Relationship, Drug; Etorphine; Feeding Behavior; Helix, Snails; Morphine; Naloxone | 1986 |
Chronic exposure to opiate agonists increases proenkephalin biosynthesis in NG108 cells.
Topics: Animals; Cell Line; Colforsin; Enkephalin, Methionine; Enkephalins; Etorphine; Genes; Glioma; Hybrid Cells; Morphinans; Morphine; Naloxone; Neuroblastoma; Protein Precursors; RNA, Messenger; Transcription, Genetic | 1988 |
Opiates distinguish spinal excitation from inhibition evoked by noxious heat stimuli in the rat: relevance to theories of analgesia.
Topics: Analgesia; Animals; Etorphine; gamma-Aminobutyric Acid; Hot Temperature; Injections, Intravenous; Male; Morphine; Naloxone; Narcotics; Rats; Rats, Inbred Strains; Spinal Cord | 1988 |
Mechanism for the opioid-induced twitch potentiations of frog's skeletal muscle.
Topics: Animals; Calcium; Dextrorphan; Etorphine; In Vitro Techniques; Meperidine; Methadone; Morphine; Muscle Contraction; Muscles; Narcotics; Rana pipiens; Stimulation, Chemical | 1986 |
Uptake of opioid drugs by rat cerebrocortical brain slices.
Topics: Animals; Cell Membrane; Cerebral Cortex; Cyclazocine; Ethylketocyclazocine; Etorphine; Kinetics; Membrane Lipids; Morphinans; Morphine; Rats; Rats, Inbred Strains | 1986 |
Development of tolerance to respiratory depression in morphine- and etorphine-pellet-implanted mice.
Topics: Animals; Drug Implants; Drug Tolerance; Etorphine; Heroin; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Mice, Inbred Strains; Morphinans; Morphine; Respiration; Time Factors | 1987 |
Unidirectional non-cross-tolerance (UNCT) in rats and an apparent dissociation between narcotic tolerance and physical dependence.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Drug Implants; Drug Tolerance; Etorphine; Humans; Male; Morphine; Rats; Rats, Inbred Strains; Substance-Related Disorders | 1985 |
Selectivity in the control of opiate receptor density in the animal and in cultured fetal brain cells.
Topics: Animals; Brain; Cells, Cultured; Etorphine; Fetus; Mice; Morphine; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1984 |
The effect of tolerance on opiate dependence as measured by the adenylate cyclase rebound response to naloxone in the NG108-15 model system.
Topics: Adenylyl Cyclases; Animals; Drug Tolerance; Etorphine; Humans; Hybrid Cells; Morphine; Naloxone; Opioid-Related Disorders; Receptors, Opioid | 1984 |
[Effect of diazepam on various effects of morphine use in mice and rats].
Topics: Animals; Bicuculline; Diazepam; Drug Interactions; Etorphine; Male; Mice; Morphine; Motor Activity; Picrotoxin; Rats; Rats, Inbred Strains; Respiration; Synaptic Transmission | 1984 |
Evidence for a single opioid receptor type on the field stimulated rat vas deferens.
Topics: Animals; Benzimidazoles; beta-Endorphin; Dose-Response Relationship, Drug; Electric Stimulation; Endorphins; Enkephalins; Etorphine; Fentanyl; Male; Morphine; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Sufentanil; Vas Deferens | 1981 |
Differential analgesic cross-tolerance to morphine between lipophilic and hydrophilic narcotic agonists.
Topics: Analgesics, Opioid; Animals; Blood-Brain Barrier; Dose-Response Relationship, Drug; Drug Tolerance; Etorphine; Injections, Intraventricular; Injections, Subcutaneous; Male; Methadone; Mice; Morphine; Morphine Derivatives; Narcotics; Receptors, Opioid | 1984 |
Dose-dependent effects of prolyl-leucyl-glycinamide on morphine-induced analgesia, tolerance and dependence.
Topics: Analgesia; Animals; Body Temperature; Body Weight; Brain Chemistry; Drug Tolerance; Etorphine; Humans; Kinetics; Male; Mice; Morphine; Morphine Dependence; MSH Release-Inhibiting Hormone; Naloxone; Reaction Time; Receptors, Opioid | 1984 |
Central and peripheral inhibition of gastrointestinal transit in rats: narcotics differ substantially by acting at either or both levels.
Topics: Analgesics, Opioid; Animals; Etorphine; Gastrointestinal Motility; Heroin; Injections, Intraperitoneal; Injections, Intraventricular; Male; Meperidine; Morphine; Naloxone; Rats | 1984 |
Opiates and thermoregulation in mice. I. Agonists.
Topics: Animals; Benzimidazoles; Body Temperature Regulation; Codeine; Dose-Response Relationship, Drug; Etorphine; Fentanyl; Hydromorphone; Isonipecotic Acids; Levorphanol; Male; Meperidine; Methadone; Mice; Morphine; Narcotics; Oxymorphone | 1980 |
Control of guinea pig intestinal electrolyte secretion by a delta-opiate receptor.
Topics: Animals; Chlorides; Electric Conductivity; Endorphins; Etorphine; Female; Fentanyl; Guinea Pigs; Intestinal Mucosa; Membrane Potentials; Morphine; Muscle, Smooth; Naloxone; Receptors, Opioid | 1980 |
Conditioned increases in locomotor activity produced with morphine as an unconditioned stimulus, and the relation of conditioning to acute morphine effect and tolerance.
Topics: Animals; Conditioning, Classical; Dose-Response Relationship, Drug; Drug Tolerance; Etorphine; Male; Morphine; Motor Activity; Naloxone; Rats; Receptors, Opioid; Reinforcement, Psychology; Social Environment | 1981 |
Quaternary naltrexone: evidence for the central mediation of discriminative stimulus effects of narcotic agonists and antagonists.
Topics: Animals; Brain; Columbidae; Discrimination, Psychological; Etorphine; Macaca mulatta; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Receptors, Opioid | 1981 |
The sensitivity of opiate receptors and ligands to short wavelength ultraviolet light.
Topics: Animals; Caudate Nucleus; Etorphine; In Vitro Techniques; Ligands; Morphine; Narcotics; Receptors, Opioid; Sheep; Ultraviolet Rays | 1981 |
[3H]Etorphine receptor binding in vivo. Small fractional occupancy elicits analgesia.
Topics: Analgesics; Animals; Brain; Drug Interactions; Etorphine; Guanylyl Imidodiphosphate; Morphinans; Morphine; Rats; Reaction Time; Receptors, Opioid; Stereoisomerism; Time Factors | 1982 |
Allosteric coupling between morphine and enkephalin receptors in vitro.
Topics: Allosteric Site; Animals; beta-Endorphin; Binding, Competitive; Endorphins; Etorphine; In Vitro Techniques; Kinetics; Models, Biological; Morphine; Rats; Receptors, Opioid | 1982 |
Possible presynaptic inhibitory effect of etorphine on sympathetic nerve terminals of guinea-pig heart.
Topics: Animals; Dose-Response Relationship, Drug; Etorphine; Guinea Pigs; Heart; In Vitro Techniques; Morphinans; Morphine; Myocardial Contraction; Receptors, Opioid; Sympathetic Nervous System | 1982 |
Etorphine binds to multiple opiate receptors of the caudate nucleus with equal affinity but with different kinetics.
Topics: Animals; Binding, Competitive; Caudate Nucleus; Diprenorphine; Edetic Acid; Etorphine; In Vitro Techniques; Kinetics; Membranes; Morphinans; Morphine; Naloxone; Receptors, Opioid; Sodium Chloride | 1982 |
Down regulation of enkephalin (delta) receptors. Demonstration in membrane-bound and solubilized receptors.
Topics: Alkaloids; Animals; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Etorphine; Glioma; Hybrid Cells; In Vitro Techniques; Morphine; Neuroblastoma; Rats; Receptors, Opioid; Solubility | 1982 |
Effects of opiate antagonists and putative mu- and kappa-agonists on milk intake in rat and squirrel monkey.
Topics: Animals; Buprenorphine; Cyclazocine; Diazepam; Diprenorphine; Drinking; Ethylketocyclazocine; Etorphine; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri; Taste | 1982 |
Functional opiate receptor in mouse vas deferens: evidence for a complex interaction.
Topics: Animals; Arylsulfatases; beta-Endorphin; Dose-Response Relationship, Drug; Drug Interactions; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Male; Mice; Mice, Inbred ICR; Morphine; Muscle Contraction; Naloxone; Receptors, Opioid; Sulfatases; Vas Deferens | 1983 |
Chronic naltrexone increases opiate binding in brain and produces supersensitivity to morphine in the locus coeruleus of the rat.
Topics: Animals; Brain; Etorphine; Locus Coeruleus; Male; Morphine; Naloxone; Naltrexone; Narcotics; Neurons; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Synaptic Transmission; Yohimbine | 1983 |
Antagonism of morphine-induced analgesia, tolerance and dependence by alpha-melanocyte-stimulating hormone.
Topics: Analgesia; Animals; Brain; Drug Interactions; Etorphine; Male; Melanocyte-Stimulating Hormones; Mice; Morphine; Receptors, Opioid | 1984 |
Bremazocine induces antinociception, but prevents opioid-induced constipation and catatonia in rats and precipitates withdrawal in morphine-dependent rats.
Topics: Analgesics; Animals; Benzomorphans; Catatonia; Constipation; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Gastrointestinal Motility; Humans; Male; Morphinans; Morphine; Naloxone; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders | 1984 |
Evaluation of new compounds for opioid activity in rhesus monkey, rat, and mouse (1984)
Topics: Animals; Binding, Competitive; Chemical Phenomena; Chemistry; Etorphine; Injections, Intravenous; Macaca mulatta; Male; Mice; Morphine; Muscle, Smooth; Narcotics; Opioid-Related Disorders; Rats; Rats, Inbred Strains; Self Administration; Stereoisomerism | 1984 |
Feline analgesia following central administration of opioids.
Topics: Analgesia; Animals; Cats; Etorphine; Injections, Subcutaneous; Male; Methadone; Microinjections; Morphine; Narcotics; Periaqueductal Gray; Reaction Time | 1984 |
Differential tolerance to the intestinal inhibitory effect of opiates in mice.
Topics: Animals; Dose-Response Relationship, Drug; Drug Implants; Drug Tolerance; Etorphine; Gastrointestinal Motility; Heroin; Injections, Intraventricular; Male; Mice; Morphine; Narcotics | 1983 |
Withdrawal tolerance and unidirectional non-cross-tolerance in narcotic pellet-implanted mice.
Topics: Animals; Dose-Response Relationship, Drug; Drug Implants; Drug Tolerance; Etorphine; Heroin; Humans; Male; Methadone; Mice; Morphine; Narcotics; Opioid-Related Disorders; Solubility; Substance Withdrawal Syndrome | 1983 |
Log dose/response curve flattening in rats after daily injection of opiates.
Topics: Analgesics; Animals; Body Temperature; Dose-Response Relationship, Drug; Drug Tolerance; Etorphine; Humans; Morphine; Narcotics; Rats; Reaction Time; Substance Withdrawal Syndrome | 1980 |
Discriminative stimulus effects of etorphine in Rhesus monkeys.
Topics: Animals; Codeine; Cyclazocine; Discrimination Learning; Ethylketocyclazocine; Etorphine; Macaca mulatta; Male; Meperidine; Morphinans; Morphine; Pentazocine; Phenazocine; Sodium Chloride | 1981 |
Cross tolerance to etorphine in rats tolerant to morphine-induced antidiuresis.
Topics: Animals; Diuresis; Drug Tolerance; Etorphine; Male; Morphinans; Morphine; Rats; Rats, Inbred Strains | 1982 |
The role of calmodulin in opioid-induced changes in the phosphorylation of rat striatal synaptic membrane proteins.
Topics: Animals; Calcium; Calcium-Binding Proteins; Calmodulin; Corpus Striatum; Etorphine; Kinetics; Male; Membrane Proteins; Methadone; Morphinans; Morphine; Phosphorylation; Protein Kinases; Rats; Synaptic Membranes; Synaptosomes | 1982 |
Enhancement of etorphine brain concentrations and changes in etorphine-naloxone pA2 values in morphine-pretreated mice.
Topics: Analgesics; Animals; Binding Sites; Brain; Etorphine; Male; Morphinans; Morphine; Naloxone; Rats | 1981 |
Unidirectional non-cross tolerance to etorphine in morphine-tolerant mice and role of the blood-brain barrier.
Topics: Analgesia; Animals; Blood-Brain Barrier; Drug Implants; Drug Tolerance; Etorphine; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Morphinans; Morphine | 1980 |
The effect of intrinsic efficacy on opioid tolerance.
Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Etorphine; Fentanyl; Male; Meperidine; Mice; Morphine; Narcotics; Oxycodone | 1995 |
Spinal and supraspinal effects of pertussis toxin on opioid analgesia.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Etorphine; Fentanyl; Injections, Intraventricular; Injections, Spinal; Male; Mice; Morphine; Narcotic Antagonists; Narcotics; Pain Measurement; Pertussis Toxin; Spinal Cord; Virulence Factors, Bordetella | 1994 |
Different subtypes of opioid receptors have different affinities for G-proteins.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Amino Acid Sequence; Animals; Binding, Competitive; Cerebellum; Colforsin; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; GTP-Binding Proteins; Guinea Pigs; Humans; Hybrid Cells; Molecular Sequence Data; Morphine; Naloxone; Neoplasm Proteins; Nerve Tissue Proteins; Neuroblastoma; Oligopeptides; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured | 1994 |
Receptor-mediated regulation of neuropeptide gene expression in astrocytes.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Astrocytes; Benzomorphans; Brain; Enkephalin, Methionine; Etorphine; Gene Expression Regulation; Morphine; Naltrexone; Nerve Tissue Proteins; Neuropeptides; Organ Specificity; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Receptors, Opioid | 1994 |
In vivo apparent pA2 analysis for naltrexone antagonism of discriminative stimulus and analgesic effects of opiate agonists in rats.
Topics: Analgesia; Animals; Benzomorphans; Buprenorphine; Discrimination, Psychological; Etorphine; Fentanyl; Male; Morphine; Nalbuphine; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1994 |
Antagonists at excitatory opioid receptors on sensory neurons in culture increase potency and specificity of opiate analgesics and attenuate development of tolerance/dependence.
Topics: Analgesics; Animals; Cells, Cultured; Diprenorphine; Drug Tolerance; Electrophysiology; Enkephalin, Leucine-2-Alanine; Etorphine; Ganglia, Spinal; Mice; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Neurons, Afferent; Opioid-Related Disorders | 1994 |
Antinociceptive effect of dihydroetorphine and its tolerance/dependence liability in mice.
Topics: Analgesics; Animals; Body Weight; Drug Tolerance; Etorphine; Male; Mice; Mice, Inbred Strains; Morphine; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Substance-Related Disorders | 1993 |
Opioid antagonist-induced receptor upregulation: effects of concurrent agonist administration.
Topics: Animals; Brain; Drug Combinations; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Fentanyl; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Up-Regulation | 1994 |
Opioid receptor regulation in mice.
Topics: Analgesics; Animals; Brain; Etorphine; Fentanyl; Male; Mice; Morphine; Naloxone; Narcotics; Receptors, Opioid, mu | 1993 |
Agonist regulation of the expression of the delta opioid receptor in NG108-15 cells.
Topics: Animals; Blotting, Northern; Cell Line; Diprenorphine; Down-Regulation; Etorphine; Hybrid Cells; Membrane Proteins; Mice; Morphine; Nalorphine; Narcotic Antagonists; Narcotics; Neuroblastoma; Rats; Receptors, Opioid, delta; RNA, Messenger | 1995 |
Morphine activates opioid receptors without causing their rapid internalization.
Topics: Cell Line; Endocytosis; Enkephalins; Etorphine; Fluorescent Antibody Technique; Humans; Morphine; Receptors, Opioid | 1996 |
The stimulatory effect of opioids on mitogen-activated protein kinase in Chinese hamster ovary cells transfected to express mu-opioid receptors.
Topics: Animals; Benzeneacetamides; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Etorphine; Morphine; Narcotics; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Transfection; Virulence Factors, Bordetella | 1996 |
Central opiate modulation of peripheral IL-6 in rats.
Topics: Animals; beta-Endorphin; Etorphine; Injections, Intraperitoneal; Injections, Intraventricular; Interleukin-1; Interleukin-6; Male; Morphine; Naloxone; Narcotics; Rats; Rats, Sprague-Dawley | 1996 |
The antiproliferative effect of opioid receptor agonists on the T47D human breast cancer cell line, is partially mediated through opioid receptors.
Topics: Adenocarcinoma; Amino Acid Sequence; Binding Sites; Breast Neoplasms; Cell Division; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Etorphine; Humans; Molecular Sequence Data; Morphine; Narcotic Antagonists; Opioid Peptides; Receptors, Opioid; Tumor Cells, Cultured | 1996 |
A potent mu-opioid receptor agonist, dihydroetorphine, fails to produce the conditioned place preference in mice.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Choice Behavior; Conditioning, Operant; Conditioning, Psychological; Dose-Response Relationship, Drug; Etorphine; Male; Mice; Morphine; Morphine Dependence | 1996 |
Agonist and antagonist properties of dihydroetorphine for mu-opioid receptors in mice.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Etorphine; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Nociceptors; Pain Measurement; Receptors, Opioid, mu | 1996 |
Antinociceptive effect of dihydroetorphine following various routes of administration: a comparative study with morphine.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Etorphine; Male; Mice; Mice, Inbred Strains; Morphine; Pain Measurement | 1996 |
Chronic morphine-treated sensory ganglion neurons remain supersensitive to the excitatory effects of naloxone for months after return to normal culture medium: an in vitro model of 'protracted opioid dependence'.
Topics: Animals; Culture Media; Etorphine; Ganglia, Spinal; Mice; Mice, Inbred Strains; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Neurons; Reference Values; Substance-Related Disorders; Time Factors | 1995 |
Differential opioid agonist regulation of the mouse mu opioid receptor.
Topics: Adenylate Cyclase Toxin; Analgesics; Animals; Buprenorphine; Colforsin; Cyclic AMP; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Levorphanol; Methadone; Mice; Morphine; Pertussis Toxin; Receptors, Opioid, mu; Virulence Factors, Bordetella | 1997 |
Etorphine elicits anomalous excitatory opioid effects on sensory neurons treated with GM1 ganglioside or pertussis toxin in contrast to its potent inhibitory effects on naive or chronic morphine-treated cells.
Topics: Action Potentials; Analgesics, Opioid; Animals; Culture Techniques; Dose-Response Relationship, Drug; Electrophysiology; Etorphine; G(M1) Ganglioside; Ganglia, Spinal; Mice; Morphine; Neurons, Afferent; Patch-Clamp Techniques; Pertussis Toxin; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Virulence Factors, Bordetella | 1996 |
Potent reinforcing effects of dihydroetorphine in rats.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Etorphine; Fentanyl; Heroin; Male; Morphine; Morphine Derivatives; Rats; Rats, Inbred F344; Substance Withdrawal Syndrome; Substance-Related Disorders | 1997 |
Ultra-low doses of naltrexone or etorphine increase morphine's antinociceptive potency and attenuate tolerance/dependence in mice.
Topics: Administration, Oral; Analgesics, Opioid; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Tolerance; Etorphine; Infusions, Parenteral; Male; Mice; Mice, Inbred Strains; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Narcotics; Nociceptors; Substance Withdrawal Syndrome; Substance-Related Disorders | 1997 |
[Effect of dihydroetorphini hydrochloride on mice parturition].
Topics: Abdominal Pain; Analgesics, Opioid; Anesthetics, Local; Animals; Etorphine; Female; Labor, Obstetric; Mice; Morphine; Pregnancy; Procaine | 1996 |
Efficacy and kinetics of opioid action on acutely dissociated neurons.
Topics: Animals; Brimonidine Tartrate; Calcium Channels; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Etorphine; Locus Coeruleus; Morphine; Narcotics; Potassium Channels; Quinoxalines | 1997 |
Ultrastructural changes in rat locus coeruleus induced by chronic opioids.
Topics: Analgesics; Animals; Endoplasmic Reticulum, Rough; Etorphine; Locus Coeruleus; Male; Morphine; Myelin Sheath; Naloxone; Narcotic Antagonists; Narcotics; Neurons; Polyribosomes; Rats; Rats, Wistar; Synaptic Vesicles | 1997 |
Opioid regulation of the mouse delta-opioid receptor expressed in human embryonic kidney 293 cells.
Topics: Adenylyl Cyclases; Animals; Antibodies, Monoclonal; Cell Line; Colforsin; Cyclic AMP; Down-Regulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; GTP-Binding Proteins; Humans; Methadone; Mice; Morphine; Point Mutation; Radioligand Assay; Receptors, Opioid, delta; Signal Transduction; Structure-Activity Relationship | 1997 |
Agonist-induced signaling and trafficking of the mu-opioid receptor: role of serine and threonine residues in the third cytoplasmic loop and C-terminal domain.
Topics: Adenylyl Cyclases; Animals; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Activation; Etorphine; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Humans; Morphine; Mutagenesis, Site-Directed; Receptors, Opioid, mu; Serine; Signal Transduction; Threonine | 1997 |
Clocinnamox antagonism of the antinociceptive effects of mu opioids in squirrel monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Combined; Animals; Antigens, CD; Buprenorphine; Cell Adhesion Molecules; Cinnamates; Etorphine; Glycoproteins; Male; Morphine; Morphine Derivatives; Narcotic Antagonists; Pain Measurement; Saimiri | 1998 |
Role for G protein-coupled receptor kinase in agonist-specific regulation of mu-opioid receptor responsiveness.
Topics: Cell Line; Etorphine; Gene Transfer Techniques; GTP-Binding Proteins; Humans; Morphine; Narcotics; Protein Kinases; Receptors, Opioid, mu; Signal Transduction | 1998 |
Anti-allodynic actions of intravenous opioids in the nerve injured rat: potential utility of heroin and dihydroetorphine against neuropathic pain.
Topics: Analgesics, Opioid; Animals; Drug Evaluation; Etorphine; Fentanyl; Heroin; Infusions, Intravenous; Ligation; Male; Morphine; Nerve Compression Syndromes; Pain; Rats; Rats, Inbred F344; Spinal Nerves | 1998 |
Phosducin, beta-arrestin and opioid receptor migration.
Topics: Analgesics, Opioid; Animals; Antibodies; Arrestin; Blotting, Western; Cell Membrane; Drug Interactions; Electrophoresis; Endocytosis; Etorphine; Eye Proteins; Fluorescence; Glioma; GTP-Binding Protein Regulators; GTP-Binding Proteins; Mice; Microscopy, Confocal; Morphine; Neuroblastoma; Phosphoproteins; Rats; Receptors, Opioid, mu; Transfection; Tumor Cells, Cultured | 1999 |
Dissociation of functional roles of dynamin in receptor-mediated endocytosis and mitogenic signal transduction.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Dynamins; Endocytosis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Activation; Etorphine; GTP Phosphohydrolases; GTP-Binding Proteins; Humans; Morphine; Phosphorylation; Receptors, Opioid; Signal Transduction; Transfection | 1999 |
Functional dissociation of mu opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction.
Topics: Arrestin; Cell Line; Drug Tolerance; Electrophysiology; Endocytosis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Flow Cytometry; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Guanine Nucleotides; Humans; Immunohistochemistry; Ligands; Morphine; Narcotics; Opioid-Related Disorders; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Muscarinic; Receptors, Opioid, mu; Signal Transduction | 1999 |
Differential binding properties of oripavines at cloned mu- and delta-opioid receptors.
Topics: Analgesics, Opioid; Animals; Benzamides; Binding, Competitive; Buprenorphine; Cloning, Molecular; Diprenorphine; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Fentanyl; Guanosine 5'-O-(3-Thiotriphosphate); Morphine; Naloxone; Piperazines; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Sulfur Radioisotopes; Thebaine; Tritium; Tumor Cells, Cultured | 1999 |
Effects of opioid receptor agonists on cAMP second messenger system.
Topics: Adenylyl Cyclases; Analgesics, Opioid; Buprenorphine; Cyclic AMP; Etorphine; Glioma; Humans; Hybrid Cells; Methadone; Morphine; Neuroblastoma; Opioid-Related Disorders; Receptors, Opioid; Receptors, Opioid, delta; Tumor Cells, Cultured | 1999 |
Effects of low-pH treatment on cAMP second messenger system regulated by different opioid agonists.
Topics: Adenylyl Cyclases; Analgesics, Opioid; Buprenorphine; Cyclic AMP; Etorphine; Glioma; Humans; Hybrid Cells; Hydrogen-Ion Concentration; Methadone; Morphine; Neuroblastoma; Opioid-Related Disorders; Receptors, Opioid, delta; Tumor Cells, Cultured | 1999 |
Agonist selective mu-opioid receptor trafficking in rat central nervous system.
Topics: Animals; Corpus Striatum; Etorphine; Fluorescent Antibody Technique; Microscopy, Confocal; Morphine; Rats; Receptors, Opioid, mu; Spinal Cord | 2000 |
Sex-related differences in the antinociceptive effects of opioids: importance of rat genotype, nociceptive stimulus intensity, and efficacy at the mu opioid receptor.
Topics: Analgesics, Opioid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Buprenorphine; Butorphanol; Cycloparaffins; Dose-Response Relationship, Drug; Etorphine; Female; Genotype; Levorphanol; Male; Morphine; Nalbuphine; Rats; Rats, Inbred F344; Rats, Inbred Lew; Reaction Time; Receptors, Opioid, mu; Sex Factors; Species Specificity; Tetrahydronaphthalenes | 2000 |
Role of cAMP-dependent protein kinase (PKA) in opioid agonist-induced mu-opioid receptor downregulation and tolerance in mice.
Topics: Analgesics, Opioid; Animals; Brain; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Male; Mice; Morphine; Oligonucleotides, Antisense; Pain Measurement; Receptors, Opioid, mu | 2000 |
Attenuation of mu-opioid tolerance and cross-tolerance by the competitive N-methyl-D-aspartate receptor antagonist LY235959 is related to tolerance and cross-tolerance magnitude.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cycloparaffins; Dose-Response Relationship, Drug; Drug Tolerance; Etorphine; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Morphine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu; Tetrahydronaphthalenes | 2000 |
Acute thermal hyperalgesia elicited by low-dose morphine in normal mice is blocked by ultra-low-dose naltrexone, unmasking potent opioid analgesia.
Topics: Acute Disease; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Etorphine; Hot Temperature; Hyperalgesia; Male; Mice; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Pain Threshold; Receptors, Opioid | 2001 |
Tolerance to analgesia and dependence liability by topical application of dihydroetorphine to hairless rats.
Topics: Administration, Cutaneous; Analgesics, Opioid; Animals; Conditioning, Psychological; Dose-Response Relationship, Drug; Drug Tolerance; Etorphine; Formaldehyde; Inflammation; Infusions, Intravenous; Injections, Subcutaneous; Male; Morphine; Naloxone; Narcotic Antagonists; Rats; Rats, Nude; Substance-Related Disorders; Time Factors; Weight Loss | 2001 |
Internalization of mu-opioid receptors produced by etorphine in the rat locus coeruleus.
Topics: Animals; Biological Transport; Etorphine; Immunohistochemistry; Locus Coeruleus; Male; Morphine; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Time Factors | 2001 |
Opioid agonists differentially regulate mu-opioid receptors and trafficking proteins in vivo.
Topics: Analgesics, Opioid; Animals; beta-Adrenergic Receptor Kinases; Binding Sites; Cyclic AMP-Dependent Protein Kinases; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; G-Protein-Coupled Receptor Kinase 3; Male; Mice; Morphine; Receptors, Opioid, mu; RNA, Messenger | 2002 |
Role of G(i)alpha2-protein in opioid tolerance and mu-opioid receptor downregulation in vivo.
Topics: Animals; Blotting, Western; Brain; Down-Regulation; Drug Tolerance; Etorphine; Heterotrimeric GTP-Binding Proteins; Injections, Intraventricular; Male; Mice; Morphine; Narcotics; Oligodeoxyribonucleotides, Antisense; Pain Measurement; Receptors, Opioid, mu; Reverse Transcriptase Polymerase Chain Reaction; Spinal Cord | 2003 |
Potency differences for D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 as an antagonist of peptide and alkaloid micro-agonists in an antinociception assay.
Topics: Alkaloids; Analgesics, Opioid; Animals; Binding, Competitive; Buprenorphine; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Injections, Intraventricular; Injections, Subcutaneous; Male; Morphine; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pain Measurement; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, mu; Somatostatin | 2003 |
Activity of opioid ligands in cells expressing cloned mu opioid receptors.
Topics: Azocines; beta-Endorphin; Binding, Competitive; Butorphanol; Cell Line; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Fentanyl; Humans; Hydromorphone; Ligands; Morphine; Naltrexone; Phenazocine; Radioligand Assay; Receptors, Opioid, mu; Tritium | 2003 |
Discriminative stimulus and antinociceptive effects of dihydroetorphine in rhesus monkeys.
Topics: Analgesics, Opioid; Animals; Discrimination Learning; Etorphine; Female; Macaca mulatta; Male; Morphine; Naltrexone | 2003 |
Opioids and the apoptotic pathway in human cancer cells.
Topics: Annexin A5; Apoptosis; Cell Adhesion; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Growth Substances; Humans; In Situ Nick-End Labeling; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Necrosis; Neoplasms; Tumor Cells, Cultured | 2003 |
Regulation of delta-opioid receptor trafficking via mu-opioid receptor stimulation: evidence from mu-opioid receptor knock-out mice.
Topics: Animals; Area Under Curve; Behavior, Animal; Cell Membrane; Dose-Response Relationship, Drug; Drug Administration Schedule; Etorphine; Female; Fentanyl; Male; Methadone; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Narcotics; Pain Measurement; Posterior Horn Cells; Protein Transport; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Time; Up-Regulation | 2003 |
Sex differences in opioid-induced enhancement of contact hypersensitivity.
Topics: Animals; Buprenorphine; Castration; Dermatitis, Contact; Etorphine; Female; Gonadal Steroid Hormones; Male; Morphine; Naltrexone; Rats; Rats, Inbred F344; Receptors, Opioid, mu; Sex Characteristics | 2003 |
Extracellular signal-regulated kinase/mitogen-activated protein kinases block internalization of delta-opioid receptors.
Topics: Arrestins; Biological Transport; Cells, Cultured; Drug Interactions; Endocytosis; Enzyme Activation; Etorphine; Flavonoids; Glutamic Acid; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Morphine; Naphthalenes; Phosphoproteins; Phosphorylation; Receptors, Opioid, delta; Tyrphostins | 2004 |
Opioid agonist and antagonist treatment differentially regulates immunoreactive mu-opioid receptors and dynamin-2 in vivo.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Blotting, Western; Dynamin II; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Male; Mice; Morphine; Naloxone; Narcotic Antagonists; Radioligand Assay; Receptors, Opioid, mu; Spinal Cord | 2004 |
Opioid control of MAP kinase cascade.
Topics: Cell Line; Dipeptides; Epidermal Growth Factor; ErbB Receptors; Etorphine; Humans; Ligands; MAP Kinase Signaling System; Morphine; Naloxone; Narcotics; Oligopeptides; Phenylalanine; Phosphorylation; Receptors, sigma; Thiophenes; Transfection | 2004 |
mu-Opioid receptor internalization-dependent and -independent mechanisms of the development of tolerance to mu-opioid receptor agonists: Comparison between etorphine and morphine.
Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Neuroglia; Neurons; Pain; Phosphorylation; Protein Transport; Receptors, Opioid, mu; Spinal Cord; Xanthines | 2006 |
Agonist-dependent postsynaptic effects of opioids on miniature excitatory postsynaptic currents in cultured hippocampal neurons.
Topics: Analgesics, Opioid; Animals; Cells, Cultured; Dendrites; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Excitatory Postsynaptic Potentials; Green Fluorescent Proteins; Hippocampus; Image Processing, Computer-Assisted; Mice; Morphine; Neostriatum; Neurons; Rats; Stimulation, Chemical; Transfection | 2007 |
Opioid agonist efficacy predicts the magnitude of tolerance and the regulation of mu-opioid receptors and dynamin-2.
Topics: Alkylation; Analgesics, Opioid; Animals; Binding, Competitive; Cinnamates; Dose-Response Relationship, Drug; Down-Regulation; Drug Tolerance; Dynamin II; Etorphine; Male; Mice; Morphine; Morphine Derivatives; Narcotic Antagonists; Oxycodone; Pain Measurement; Pain Threshold; Predictive Value of Tests; Protein Processing, Post-Translational; Reaction Time; Receptors, Opioid, mu; Spinal Cord | 2007 |
Agonist treatment did not affect association of mu opioid receptors with lipid rafts and cholesterol reduction had opposite effects on the receptor-mediated signaling in rat brain and CHO cells.
Topics: Animals; Binding, Competitive; Brain; Caveolin 1; CHO Cells; Cholesterol; Cricetinae; Cricetulus; Diprenorphine; Dose-Response Relationship, Drug; Etorphine; Male; Membrane Microdomains; Morphine; Naloxone; Narcotic Antagonists; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Signal Transduction; Transfection | 2007 |
Agonist-selective signaling is determined by the receptor location within the membrane domains.
Topics: Animals; Arrestins; beta-Arrestins; beta-Cyclodextrins; Cell Line; Colforsin; Etorphine; Gene Deletion; GTP-Binding Protein alpha Subunit, Gi2; Humans; Male; Membrane Microdomains; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Morphine; Mutant Proteins; Protein Binding; Protein Transport; Receptors, Opioid, mu; Signal Transduction | 2008 |
Differential activation and trafficking of micro-opioid receptors in brain slices.
Topics: Analgesics, Opioid; Animals; Brain; Chelating Agents; Egtazic Acid; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Fluorescent Antibody Technique, Direct; Locus Coeruleus; Methadone; Mice; Mice, Knockout; Mice, Transgenic; Morphine; Neurons; Oxycodone; Oxymorphone; Protein Transport; Radioligand Assay; Receptors, Opioid, mu; Recombinant Fusion Proteins; Time Factors | 2008 |
Differential effects of opioid agonists on G protein expression in CHO cells expressing cloned human opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Benzamides; Blotting, Western; CHO Cells; Cricetinae; Cricetulus; Diterpenes, Clerodane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Female; Furans; Gene Expression; GTP-Binding Protein alpha Subunits, G12-G13; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Morphine; Oligopeptides; Piperazines; Pyrones; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2008 |
Down-regulation of c-Cbl by morphine accounts for persistent ERK1/2 signaling in delta-opioid receptor-expressing HEK293 cells.
Topics: Animals; Cell Line; CSK Tyrosine-Protein Kinase; Down-Regulation; Enzyme Activation; ErbB Receptors; Etorphine; Humans; MAP Kinase Signaling System; Membrane Microdomains; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morphine; Narcotics; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-cbl; Receptors, Opioid, delta; RNA, Small Interfering; src-Family Kinases | 2009 |
Paradoxical relationship between RAVE (relative activity versus endocytosis) values of several opioid receptor agonists and their liability to cause dependence.
Topics: Analgesics, Opioid; Animals; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Endocytosis; Etorphine; Fentanyl; Guanosine 5'-O-(3-Thiotriphosphate); Morphine; Opioid-Related Disorders; Receptors, Opioid, mu | 2010 |
Modulating micro-opioid receptor phosphorylation switches agonist-dependent signaling as reflected in PKCepsilon activation and dendritic spine stability.
Topics: Analgesics, Opioid; Animals; Arrestins; beta-Arrestins; Cell Line; Dendritic Spines; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Fentanyl; Humans; Mice; Morphine; Phosphorylation; Protein Kinase C-epsilon; Receptors, Opioid, mu; Signal Transduction | 2011 |
Posttranslation modification of G protein-coupled receptor in relationship to biased agonism.
Topics: Animals; Arrestins; beta-Arrestins; Cyclic AMP; Etorphine; Gene Expression; HEK293 Cells; Humans; Lipoylation; Membrane Microdomains; Morphine; Neurons; Phosphorylation; Primary Cell Culture; Protein Processing, Post-Translational; Rats; Receptors, Opioid, mu; Signal Transduction | 2013 |
T394A Mutation at the μ Opioid Receptor Blocks Opioid Tolerance and Increases Vulnerability to Heroin Self-Administration in Mice.
Topics: Analgesia; Analgesics, Opioid; Animals; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Heroin Dependence; Male; Mice; Mice, Inbred C57BL; Morphine; Motor Activity; Mutation; Pain Measurement; Phosphorylation; Point Mutation; Receptors, Opioid, mu; Reward; Self Administration | 2016 |