Page last updated: 2024-08-23

etorphine and enkephalin, leucine

etorphine has been researched along with enkephalin, leucine in 117 studies

Research

Studies (117)

TimeframeStudies, this research(%)All Research%
pre-199080 (68.38)18.7374
1990's35 (29.91)18.2507
2000's2 (1.71)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Keane, PE; Neal, H1
Coale, EH; Hein, DW; Herling, S; Valentino, RJ; Woods, JH1
Brandt, M; Glaser, T; Hamprecht, B; Klebensberger, W; Traber, J1
Blume, AJ; Finberg, JP; Shorr, J; Spector, S1
Lin, HK; Simon, EJ1
Blume, AJ2
Makman, MH; Walczak, SA; Wilkening, D1
Altstein, M; Vogel, Z1
Meunier, JC; Zajac, JM1
Felix, D; Frangi, U; Henke, H1
Chance, WT; Krynock, GM; Rosecrans, JA; White, AC1
Li, CH; Loh, HH; Tseng, LF; Wei, ET1
Barnard, EA; Demoliou-Mason, C; Richardson, A1
Elde, R; Lane, CM; Lee, NM; Loh, HH1
Edwards, RH; Evans, CJ; Keith, DE; Magendzo, K; Morrison, H1
Chang, LR; Loh, HH; Tao, PL; Tsai, CL1
DiMaio, J; Michel, A; Villeneuve, G1
Boer, HH; Leung, MK; Lundy, J; Stefano, GB; van Minnen, J1
Höllt, V; Simantov, R1
Katki, AG; Schwarz, S1
Biswas, R; Maneckjee, R; Vonderhaar, BK1
Durie, E; Michel, AD; Sharif, NA; Whiting, RL1
Klein, P; Nelson, WL; Simon, EJ; Yao, YH1
Mosberg, HI; Porreca, F; Qi, JN1
Han, JS; Wang, XJ1
Coombes, JE; Pumford, KM; Russell, JA; Sumner, BE1
Cross, AJ; Hille, C; Slater, P1
Porreca, F; Tortella, FC1
Bolger, GT; Marcus, KA; Skolnick, P; Thibou, R; Weissman, BA1
Law, PY; Loh, HH; Louie, AK; Zhan, JN1
Barnard, EA; Demoliou-Mason, CD; Wong, YH1
Cros, J; Francés, B; Meunier, JC; Porthé, G; Verrier, B1
Cox, BM; McMahon, PN; Werling, LL1
Su, TP1
Frances, B; Meunier, JC; Moisand, C1
Barnard, EA; Demoliou-Mason, CD3
Buder, M; Fuder, H; Riers, HD; Rothacher, G1
Cruciani, RA; Gainer, H; Lang, MA; Pesce, GO; Rodbard, D; Russell, JT1
Archer, S; Maneckjee, R; Michael, J; Osei-Gyimah, P; Zukin, RS1
Priestley, T; Turnbull, MJ; Wei, E1
Bunn, SJ; Hanley, MR; Wilkin, GP1
Holaday, JW; Robles, L; Tortella, FC1
Garzón, J; Herz, A; Schulz, R2
Costa, T; Gramsch, C; Herz, A; Wüster, M1
Boudouresque, F; Bourhim, N; Cantau, P; Castanas, E; Giraud, P; Oliver, C1
Richards, ML; Sadée, W; Yu, VC1
Charness, ME; Diamond, I; Querimit, LA1
Klein, C; Levy, R; Simantov, R1
Coscia, CJ; Devane, WA; Howlett, AC; Spain, JW1
Brown, SR; Cote, TE; Cox, BM; Puttfarcken, P; Werling, LL1
Brown, SR; Cox, BM; Puttfarcken, P; Werling, LL1
Greenspan, DL; Musacchio, JM1
Sadée, W; Yu, VC1
Gardner, EL; Vaysse, PJ; Zukin, RS1
Gainer, H; Lang, MA; Pesce, G; Rodbard, D; Russell, JT1
Chi, ZQ; Jin, WQ; Wu, SW1
Delay-Goyet, P; Roques, BP; Zajac, JM1
Agid, Y; Delay-Goyet, P; Javoy-Agid, F; Roques, BP; Zajac, JM1
Schwartz, JP1
Bayly, CI; DiMaio, J; Michel, A; Villeneuve, G1
Anwer, MK; Bettag, AL; Browne, B; Edwards, JV; Lahti, R; Rowell, P; Saneii, H; Spatola, AF; Von Voigtlander, P1
Bourhim, N; Cantau, P; Castanas, E; Giraud, P; Oliver, C1
Griffin, MT; Law, PY; Loh, HH1
Audigier, Y; Cros, J; Duprat, AM1
Day, AR; Freer, RJ; Liao, CS1
Franklin, PH; Hoss, W2
Herkenham, M; Pert, CB1
Koshland, DE; Smolarsky, M1
Groth, J; Hiller, JM; Howells, RD; Simon, EJ1
Duka, T; Herz, A; Schubert, P; Stoiber, R; Wüster, M2
Adler, MW; Cowan, A; Tortella, FC1
Catapane, EJ; Kream, RM; Stefano, GB1
Fitz-Syage, ML; Gardner, EL; Gintzler, AR; Sugarman, JR; Zukin, RS; Zukin, SR1
Guidotti, A; Saiani, L1
Attali, B; Audigier, Y; Cros, J; Gouardères, C; Mazarguil, H1
Baram, D; Levy, R; Simantov, R1
Kouakou, Y; Meunier, JC; Moisand, C; Puget, A1
Garzón, J; Lee, NM; Sánchez-Blázquez, P1
Rothman, R; Westfall, TC1
Cowan, A; Holaday, JW; Robles, LE; Tortella, FC1
Bradbury, WM; Cooper, JR; Glasel, JA; Reese, JH; Venn, RF1
Gioannini, TL; Hiller, JM; Itzhak, Y; Simon, EJ1
Govoni, S; Lucchi, L; Rius, RA; Trabucchi, M; Uzumaki, H1
Barg, J; Lenoir, D; Simantov, R1
Gambino, MC; Petrillo, P; Tavani, A1
LaBella, FS; Pinsky, C1
Bär, PR; Gispen, WH; Schotman, P1
Gillan, MG; Kosterlitz, HW; Paterson, SJ1
Jauzac, P; Polastron, J1
Brine, GA; Carroll, FI; Ni, Q; Partilla, JS; Rothman, RB; Stark, PA; Xu, H1
Davis, T; Duttaroy, A; Shah, S; Yoburn, BC1
Lazar, DF; Medzihradsky, F1
Cote, TE; Gosse, ME; Weems, HB1
Howells, RD; Jin, J; Shahrestanifar, M; Wang, WW1
Chu, PC; Evans, CJ; Kang, L; Keith, DE; Lissin, DV; Murray, SR; von Zastrow, M; Zaki, PA1
Chang, KJ; Li, LY1
Feigenbaum, JJ; Simantov, R1
Bakogeorgou, E; Castanas, E; Hatzoglou, A1
Blake, AD; Bot, G; Freeman, JC; Reisine, T1
Ingram, S; McCleskey, EW; Wilding, TJ; Williams, JT1
Blake, AD; Bot, G; Li, S; Reisine, T1
Tseng, LF; Xu, JY1
Bertin, B; Capeyrou, R; Corbani, M; Emorine, LJ; Lepage, JF; Riond, J1
Brine, GA; Carroll, FI; Chen, C; Lai, J; Liu-Chen, LY; Lu, YF; Partilla, JS; Porreca, F; Rice, KC; Rothman, RB; Sadee, W; Xu, H1
Emorine, LJ; Exner, T; Gaibelet, G; Liaubet, L; Masson, JM; Meilhoc, E; Nürnberg, B; Riond, J; Saves, I1
Allouche, S; Jauzac, P; Marie, N; Roussel, M1
Allouche, S; Hasbi, A; Homburger, V; Jauzac, P; Polastron, J1
von Zastrow, M; Whistler, JL1
Chu, P; Chuang, HH; Jan, LY; von Zastrow, M; Whistler, JL1
Virk, MS; Williams, JT1
Ammer, H; Eisinger, DA; Heiss, A1

Other Studies

117 other study(ies) available for etorphine and enkephalin, leucine

ArticleYear
The effects of local micro injections of opiates and enkephalins into the forebrain on the electrocorticogram of the rat.
    Electroencephalography and clinical neurophysiology, 1978, Volume: 45, Issue:5

    Topics: Animals; Brain; Codeine; Electroencephalography; Endorphins; Enkephalins; Etorphine; Male; Morphinans; Morphine; Naloxone; Rats; Receptors, Dopamine; Thebaine

1978
Narcotic drug discriminations by rhesus monkeys and pigeons.
    NIDA research monograph, 1979, Volume: 27

    Topics: Animals; Columbidae; Cyclazocine; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Discrimination Learning; Dose-Response Relationship, Drug; Enkephalins; Ethylketocyclazocine; Etorphine; Hormones; Macaca; Macaca mulatta; Naltrexone; Narcotics; Phenazocine

1979
Different receptors for somatostatin and opioids in neuroblastoma X glioma hybrid cells.
    FEBS letters, 1977, Sep-15, Volume: 81, Issue:2

    Topics: Animals; Binding, Competitive; Cyclic AMP; Enkephalins; Etorphine; Glioma; Hybrid Cells; Naloxone; Neuroblastoma; Neurons; Prostaglandins E; Rats; Receptors, Cell Surface; Receptors, Opioid; Somatostatin

1977
Binding of the endogenous nonpeptide morphine-like compound to opiate receptors.
    Proceedings of the National Academy of Sciences of the United States of America, 1977, Volume: 74, Issue:11

    Topics: Animals; Binding, Competitive; Brain Chemistry; Cattle; Cell Line; Cell Membrane; Enkephalins; Etorphine; Humans; In Vitro Techniques; Morphine; Naloxone; Narcotics; Radioimmunoassay; Receptors, Opioid

1977
Phospholipase A inhibition of opiate receptor binding can be reversed by albumin.
    Nature, 1978, Jan-26, Volume: 271, Issue:5643

    Topics: Animals; Brain; Enkephalins; Etorphine; In Vitro Techniques; Male; Naltrexone; Phospholipases; Rats; Receptors, Opioid; Serum Albumin, Bovine

1978
Interaction of ligands with the opiate receptors of brain membranes: regulation by ions and nucleotides.
    Proceedings of the National Academy of Sciences of the United States of America, 1978, Volume: 75, Issue:4

    Topics: Animals; Brain; Enkephalins; Etorphine; Guanylyl Imidodiphosphate; Ligands; Male; Manganese; Morphine; Morphine Derivatives; Naltrexone; Rats; Receptors, Opioid; Ribonucleotides; Sodium

1978
Opiate binding to membrane preparations of neuroblastoma x glioma hybrid cells NG108-15: effects of ions and nucleotides.
    Life sciences, 1978, May-22, Volume: 22, Issue:20

    Topics: Cell Membrane; Cells, Cultured; Enkephalins; Etorphine; Glioma; Guanylyl Imidodiphosphate; Hybrid Cells; Magnesium; Manganese; Naloxone; Neuroblastoma; Nucleotides; Receptors, Opioid; Sodium

1978
Interaction of morphine, etorphine and enkephalins with dopamine-stimulated adenylate cyclase of monkey amygdala.
    Brain research, 1979, Jan-05, Volume: 160, Issue:1

    Topics: Adenylyl Cyclases; Amygdala; Animals; Dopamine; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Etorphine; Freezing; Haplorhini; Macaca mulatta; Morphinans; Morphine; Naloxone; Receptors, Opioid; Stimulation, Chemical

1979
The effect of puromycin on the biological activity of Leu-enkephalin.
    FEBS letters, 1979, Feb-01, Volume: 98, Issue:1

    Topics: Animals; Brain; Endorphins; Enkephalins; Etorphine; Guinea Pigs; Ileum; Kinetics; Puromycin; Rats; Receptors, Opioid

1979
Cerebellar opiate receptors in lagomorphs. Demonstration, characterization and regional distribution.
    Brain research, 1979, May-25, Volume: 168, Issue:2

    Topics: Animals; Brain Mapping; Cerebellar Cortex; Cerebellum; Cricetinae; Dextrorphan; Enkephalins; Etorphine; Female; Levorphanol; Male; Mice; Morphine; Naloxone; Rabbits; Rats; Receptors, Opioid; Species Specificity

1979
Opiate receptors in the pigeon optic tectum.
    Brain research, 1979, Oct-12, Volume: 175, Issue:1

    Topics: Animals; Columbidae; Enkephalins; Etorphine; Kinetics; Receptors, Opioid; Superior Colliculi

1979
Autoanalgesia: acquisition, blockade and relationship to opiate binding.
    European journal of pharmacology, 1979, Oct-15, Volume: 58, Issue:4

    Topics: Analgesia; Animals; Brain; Conditioning, Classical; Diazepam; Enkephalins; Etorphine; In Vitro Techniques; Male; Naltrexone; Narcotics; Rats; Reaction Time; Spinal Cord

1979
Comparison of the behavioral effects of beta-endorphin and enkephalin analogs.
    Life sciences, 1977, Aug-01, Volume: 21, Issue:3

    Topics: Animals; Behavior, Animal; Endorphins; Enkephalins; Etorphine; Male; Mice; Morphine; Motor Activity; Naloxone; Oligopeptides; Peptides; Rats

1977
Guanine nucleotide-binding protein-coupled and -uncoupled states of opioid receptors and their relevance to the determination of subtypes.
    Proceedings of the National Academy of Sciences of the United States of America, 1992, Nov-01, Volume: 89, Issue:21

    Topics: Analgesics; Animals; Benzeneacetamides; Benzomorphans; Binding, Competitive; Cell Membrane; Cerebellum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Etorphine; Female; GTP-Binding Proteins; Guinea Pigs; Humans; Kinetics; Ligands; Placenta; Pregnancy; Prosencephalon; Protein Binding; Pyrrolidines; Rats; Receptors, Opioid

1992
Regulation of an opioid-binding protein in NG108-15 cells parallels regulation of delta-opioid receptors.
    Proceedings of the National Academy of Sciences of the United States of America, 1992, Dec-01, Volume: 89, Issue:23

    Topics: Amino Acid Sequence; Animals; Carrier Proteins; Cell Adhesion Molecules; Cell Compartmentation; Cell Membrane; Cells, Cultured; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Fluorescent Antibody Technique; GPI-Linked Proteins; In Vitro Techniques; Membrane Glycoproteins; Molecular Sequence Data; Nerve Tissue Proteins; Neurons; Peptides; Rats; Receptors, Opioid, delta

1992
Cloning of a delta opioid receptor by functional expression.
    Science (New York, N.Y.), 1992, Dec-18, Volume: 258, Issue:5090

    Topics: Amino Acid Sequence; Animals; Binding, Competitive; Blotting, Northern; Blotting, Southern; Cell Line; Cyclic AMP; Diprenorphine; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; Gene Expression; Humans; Kinetics; Models, Structural; Molecular Sequence Data; Naloxone; Narcotics; Protein Structure, Secondary; Receptors, Opioid, delta; Sequence Homology, Amino Acid; Transfection; Tumor Cells, Cultured

1992
Chronic effect of [D-Pen2,D-Pen5]enkephalin on rat brain opioid receptors.
    European journal of pharmacology, 1991, Aug-29, Volume: 201, Issue:2-3

    Topics: Analgesics; Animals; Brain Chemistry; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; In Vitro Techniques; Injections, Intraventricular; Male; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu

1991
A proposal for the molecular basis of mu and delta opiate receptor differentiation based on modeling of two types of cyclic enkephalins and a narcotic alkaloid.
    Journal of computer-aided molecular design, 1991, Volume: 5, Issue:6

    Topics: Computer Graphics; Drug Design; Enkephalin, Leucine; Enkephalins; Etorphine; Models, Molecular; Molecular Structure; Peptides, Cyclic; Protein Conformation; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship; Substrate Specificity

1991
Evidence for an enkephalinergic system in the nervous system of the pond snail, Lymnaea stagnalis.
    Brain research, 1990, Oct-29, Volume: 531, Issue:1-2

    Topics: Animals; Cell Membrane; Enkephalin, Leucine; Enkephalin, Methionine; Etorphine; Immune Sera; Immunohistochemistry; Kinetics; Lymnaea; Nervous System; Nervous System Physiological Phenomena; Neuropeptides; Receptors, Opioid

1990
Regulation of proenkephalin A gene expression in aggregating fetal rat brain cells.
    Cellular and molecular neurobiology, 1991, Volume: 11, Issue:2

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Action Potentials; Animals; Brain; Cell Aggregation; Dexamethasone; Enkephalins; Etorphine; Gene Expression Regulation; Naltrexone; Neurons; Potassium Chloride; Protein Precursors; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate; Veratridine

1991
Effects of calcium-channel blockers (CCB) on mu and delta opioid receptors in rat brain membranes.
    Progress in clinical and biological research, 1990, Volume: 328

    Topics: Animals; Brain; Calcium Channel Blockers; Calcium Channels; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; In Vitro Techniques; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu

1990
Binding of opioids to human MCF-7 breast cancer cells and their effects on growth.
    Cancer research, 1990, Apr-15, Volume: 50, Issue:8

    Topics: Breast Neoplasms; Cell Division; Cell Line; Cell Membrane; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Estradiol; Etorphine; Female; Humans; Kinetics; Morphinans; Morphine; Receptors, Opioid; Tumor Cells, Cultured

1990
Dog cerebral cortex contains mu-, delta- and kappa-opioid receptors at different densities: apparent lack of evidence for subtypes of the kappa-receptor using selective radioligands.
    Brain research, 1990, Feb-26, Volume: 510, Issue:1

    Topics: Animals; Cerebral Cortex; Dogs; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Species Specificity

1990
Electrophilic alpha-methylene-gamma-lactone and isothiocyanate opioid ligands related to etorphine.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:8

    Topics: Chemical Phenomena; Chemistry; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Isothiocyanates; Lactones; Ligands; Magnetic Resonance Spectroscopy; Molecular Structure; Morphinans; Naloxone; Receptors, Opioid; Receptors, Opioid, mu; Spectrophotometry, Infrared; Stereoisomerism; Thebaine; Thiocyanates

1990
Modulation of the potency and efficacy of mu-mediated antinociception by delta agonists in the mouse.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 254, Issue:2

    Topics: Analgesics; Animals; Codeine; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphinans; Morphine; Pain Measurement; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu

1990
Modification by cholecystokinin octapeptide of the binding of mu-, delta-, and kappa-opioid receptors.
    Journal of neurochemistry, 1990, Volume: 55, Issue:4

    Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; Kinetics; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sincalide

1990
Opioid receptor subtypes in the supraoptic nucleus and posterior pituitary gland of morphine-tolerant rats.
    Neuroscience, 1990, Volume: 37, Issue:3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Autoradiography; Benzomorphans; Binding, Competitive; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; Female; Injections, Intraventricular; Morphine; Pituitary Gland, Posterior; Plasma; Preoptic Area; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Supraoptic Nucleus

1990
Subtraction autoradiography of opiate receptor subtypes in human brain.
    Brain research, 1987, Aug-25, Volume: 418, Issue:2

    Topics: Autoradiography; Binding Sites; Binding, Competitive; Brain; Cerebral Cortex; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Humans; Middle Aged; Naloxone; Receptors, Opioid; Subcellular Fractions

1987
Differential antagonism of mu agonists by U50,488H in the rat.
    Life sciences, 1987, Dec-07, Volume: 41, Issue:23

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Female; Male; Muscle Contraction; Muscle, Smooth; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Seizures; Urinary Bladder

1987
Enhancement of [3H]DAGO1 binding to rat brain by low concentrations of monovalent cations.
    Canadian journal of physiology and pharmacology, 1987, Volume: 65, Issue:11

    Topics: Animals; Batrachotoxins; Benzomorphans; Brain Chemistry; Cations, Monovalent; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Guanine Nucleotides; Guanylyl Imidodiphosphate; In Vitro Techniques; Male; Naloxone; Rats; Receptors, Opioid; Temperature

1987
Modification of opioid receptor activity by acid phosphatase in neuroblastoma x glioma NG108-15 hybrid cells.
    Biochemical and biophysical research communications, 1988, May-16, Volume: 152, Issue:3

    Topics: Acid Phosphatase; Animals; Chromatography, High Pressure Liquid; Cyclic AMP; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Glioma; Guanfacine; Guanidines; Hybrid Cells; Neuroblastoma; Phenylacetates; Receptors, Opioid

1988
ADP-ribosylation with pertussis toxin modulates the GTP-sensitive opioid ligand binding in digitonin-soluble extracts of rat brain membranes.
    Journal of neurochemistry, 1988, Volume: 51, Issue:1

    Topics: Adenosine Diphosphate Ribose; Animals; Brain; Cell Membrane; Digitonin; Electrophoresis, Polyacrylamide Gel; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; GTP-Binding Proteins; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Kinetics; Naloxone; Oligopeptides; Pertussis Toxin; Rats; Receptors, Opioid; Sodium; Solubility; Virulence Factors, Bordetella

1988
The kappa-opioid receptor from human placenta: hydrodynamic characteristics and evidence for its association with a G protein.
    Life sciences, 1988, Volume: 43, Issue:6

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Binding, Competitive; Centrifugation, Density Gradient; Chromatography, Gel; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Female; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Humans; Microvilli; Oligopeptides; Placenta; Pregnancy; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Sodium Chloride

1988
Selective tolerance at mu and kappa opioid receptors modulating norepinephrine release in guinea pig cortex.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cerebral Cortex; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Guinea Pigs; Male; Morphine; Norepinephrine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu

1988
Further demonstration of kappa opioid binding sites in the brain: evidence for heterogeneity.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 232, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Binding Sites; Brain; Cyclazocine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Guinea Pigs; Levallorphan; Peptide Fragments; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Stereoisomerism

1985
Na+ ions and Gpp(NH)p selectively inhibit agonist interactions at mu- and kappa-opioid receptor sites in rabbit and guinea-pig cerebellum membranes.
    European journal of pharmacology, 1985, Nov-05, Volume: 117, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Benzomorphans; Binding, Competitive; Cerebellum; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Guinea Pigs; Hydrogen-Ion Concentration; In Vitro Techniques; Naloxone; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium

1985
Characterization of opioid receptor subtypes in solution.
    Journal of neurochemistry, 1986, Volume: 46, Issue:4

    Topics: Animals; Brain; Cations; Cell Membrane; Chemical Phenomena; Chemistry, Physical; Chromatography, Gel; Dihydromorphine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Guanylyl Imidodiphosphate; Iodoacetamide; Kinetics; Magnesium; Naloxone; Rats; Receptors, Opioid; Sodium; Solutions

1986
On the opioid receptor subtype inhibiting the evoked release of 3H-noradrenaline from guinea-pig atria in vitro.
    Naunyn-Schmiedeberg's archives of pharmacology, 1986, Volume: 332, Issue:2

    Topics: Animals; Atropine; Benzomorphans; Binding, Competitive; Corticosterone; Cyclazocine; Desipramine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Guinea Pigs; Heart Atria; In Vitro Techniques; Morphine; Myocardium; Naloxone; Norepinephrine; Peptide Fragments; Phentolamine; Receptors, Opioid; Receptors, Opioid, kappa; Synapses

1986
Opioid receptors of bovine posterior pituitary neurosecretosomes are exclusively kappa.
    NIDA research monograph, 1986, Volume: 75

    Topics: Analgesics, Opioid; Animals; Cattle; Cyclazocine; Cytoplasmic Granules; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Kinetics; Morphinans; Pituitary Gland, Posterior; Receptors, Opioid; Receptors, Opioid, kappa

1986
Purification and characterization of the mu opiate receptor from rat brain using affinity chromatography.
    Proceedings of the National Academy of Sciences of the United States of America, 1985, Volume: 82, Issue:2

    Topics: Animals; Brain Chemistry; Cholic Acids; Chromatography, Affinity; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Kinetics; Male; Molecular Weight; Protease Inhibitors; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu

1985
In vivo evidence for the selectivity of ICI 154129 for the delta-opioid receptor.
    Neuropharmacology, 1985, Volume: 24, Issue:2

    Topics: Analgesics; Animals; Enkephalin, Leucine; Etorphine; Female; Humans; Mice; Mice, Inbred C57BL; Morphine Dependence; Motor Activity; Rats; Receptors, Opioid; Receptors, Opioid, delta

1985
Evidence for a kappa-opioid receptor on pituitary astrocytes: an autoradiographic study.
    Neuroscience letters, 1985, Apr-19, Volume: 55, Issue:3

    Topics: Animals; Astrocytes; Autoradiography; Binding Sites; Binding, Competitive; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Etorphine; Pituitary Gland; Rats; Receptors, Opioid; Receptors, Opioid, kappa

1985
The anticonvulsant effects of DADLE are primarily mediated by activation of delta opioid receptors: interactions between delta and mu receptor antagonists.
    Life sciences, 1985, Aug-12, Volume: 37, Issue:6

    Topics: Animals; Anticonvulsants; Cerebral Ventricles; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Seizures

1985
Evidence for the epsilon-type of opioid receptor in the rat vas deferens.
    Molecular pharmacology, 1985, Volume: 28, Issue:1

    Topics: Animals; Binding, Competitive; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Drug Synergism; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Etorphine; Fentanyl; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Vas Deferens

1985
Multiple states of opioid receptors may modulate adenylate cyclase in intact neuroblastoma X glioma hybrid cells.
    Molecular pharmacology, 1985, Volume: 28, Issue:2

    Topics: Adenylyl Cyclases; Animals; Cell Line; Cyclic AMP; Diprenorphine; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Glioma; Hybrid Cells; Kinetics; Ligands; Morphine; Naloxone; Neuroblastoma; Neurons; Receptors, Opioid; Receptors, Opioid, delta

1985
Interaction of opiates with opioid binding sites in the bovine adrenal medulla: II. Interaction with kappa sites.
    Journal of neurochemistry, 1985, Volume: 45, Issue:3

    Topics: Adrenal Medulla; Animals; Benzomorphans; Binding Sites; Calcium; Cattle; Cyclazocine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Ethylketocyclazocine; Ethylmaleimide; Etorphine; Guinea Pigs; Kinetics; Lithium; Manganese; Narcotics; Oligopeptides; Phospholipases A; Potassium; Receptors, Opioid; Receptors, Opioid, kappa; Sodium; Stereoisomerism

1985
A human neuroblastoma cell line expresses mu and delta opioid receptor sites.
    The Journal of biological chemistry, 1986, Jan-25, Volume: 261, Issue:3

    Topics: Bone Neoplasms; Cell Line; Child, Preschool; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Female; Guanylyl Imidodiphosphate; Humans; Kinetics; Naloxone; Neuroblastoma; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sodium Chloride

1986
Ethanol increases the expression of functional delta-opioid receptors in neuroblastoma x glioma NG108-15 hybrid cells.
    The Journal of biological chemistry, 1986, Mar-05, Volume: 261, Issue:7

    Topics: Cell Line; Cyclic AMP; Cycloheximide; Dactinomycin; Diprenorphine; DNA; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethanol; Etorphine; Glioma; Hybridomas; Naloxone; Neuroblastoma; Phenylisopropyladenosine; Receptors, Opioid; Receptors, Opioid, delta; Sodium; Transcription, Genetic

1986
Distinct subtypes of the opioid receptor with allosteric interactions in brain membranes.
    Journal of neurochemistry, 1986, Volume: 46, Issue:4

    Topics: Allosteric Site; Animals; Brain; Cations; Cell Membrane; Dihydromorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Guanylyl Imidodiphosphate; Kinetics; Magnesium; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Sodium

1986
Subcellular compartmentation of opioid receptors: modulation by enkephalin and alkaloids.
    Journal of neurochemistry, 1986, Volume: 46, Issue:4

    Topics: Animals; Cell Line; Cell Membrane; Centrifugation, Density Gradient; Chloroquine; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Glioma; Golgi Apparatus; Kinetics; Lysosomes; Microsomes; Neuroblastoma; Receptors, Opioid

1986
An assessment of the role of opioid receptors in the response to cannabimimetic drugs.
    Journal of neurochemistry, 1986, Volume: 46, Issue:6

    Topics: Adenylyl Cyclase Inhibitors; Animals; Cannabinoids; Cell Line; Dronabinol; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Etorphine; Morphine; Naltrexone; Neuroblastoma; Neurons; Receptors, Opioid; Receptors, Opioid, delta

1986
Sodium regulation of agonist binding at opioid receptors. I. Effects of sodium replacement on binding at mu- and delta-type receptors in 7315c and NG108-15 cells and cell membranes.
    Molecular pharmacology, 1986, Volume: 30, Issue:2

    Topics: Adenylyl Cyclase Inhibitors; Animals; Cell Line; Cell Membrane; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Etorphine; Glioma; Guinea Pigs; Monensin; Naloxone; Neuroblastoma; Pituitary Neoplasms; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sodium

1986
Sodium regulation of agonist binding at opioid receptors. II. Effects of sodium replacement on opioid binding in guinea pig cortical membranes.
    Molecular pharmacology, 1986, Volume: 30, Issue:2

    Topics: Animals; Cell Membrane; Cerebral Cortex; Cyclazocine; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Etorphine; Guinea Pigs; Male; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium

1986
The adenylate cyclase rebound response to naloxone in the NG108-15 cells. Effects of etorphine and other opiates.
    Neuropharmacology, 1986, Volume: 25, Issue:8

    Topics: Adenylyl Cyclases; Alprostadil; Cell Line; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Etorphine; Glioma; Morphinans; Morphine; Naloxone; Neuroblastoma; Receptors, Opioid

1986
Phosphatidylinositol turnover in neuroblastoma cells: regulation by bradykinin, acetylcholine, but not mu- and delta-opioid receptors.
    Neuroscience letters, 1986, Nov-11, Volume: 71, Issue:2

    Topics: Acetylcholine; Animals; Bradykinin; Cell Line; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Mice; Phosphatidylinositols; Rats; Receptors, Opioid

1986
Modulation of rat brain opioid receptors by cannabinoids.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:2

    Topics: Animals; Cannabinoids; Cyclazocine; Dihydromorphine; Dose-Response Relationship, Drug; Dronabinol; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Etorphine; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Spiperone

1987
Characterization of kappa opioid receptors in neurosecretosomes from bovine posterior pituitary.
    Journal of neurochemistry, 1987, Volume: 49, Issue:2

    Topics: Animals; Cattle; Cytoplasmic Granules; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Kinetics; Microscopy, Electron; Pituitary Gland, Posterior; Receptors, Opioid; Receptors, Opioid, kappa

1987
[Characterization of opioid receptors in the golden hamster brain].
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1986, Volume: 7, Issue:6

    Topics: Animals; Binding, Competitive; Brain; Brain Chemistry; Cricetinae; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Female; Male; Mesocricetus; Radioligand Assay; Receptors, Opioid

1986
Differences of binding characteristics of non-selective opiates towards mu and delta receptor types.
    Life sciences, 1987, Aug-10, Volume: 41, Issue:6

    Topics: Animals; Binding, Competitive; Brain; Cell Membrane; Cerebellum; Cyclazocine; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethylketocyclazocine; Etorphine; Male; Oligopeptides; Rabbits; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu

1987
Regional distribution of mu, delta and kappa opioid receptors in human brains from controls and parkinsonian subjects.
    Brain research, 1987, Jun-23, Volume: 414, Issue:1

    Topics: Aged; Aged, 80 and over; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Humans; Kinetics; Oligopeptides; Parkinson Disease; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu

1987
Chronic exposure to opiate agonists increases proenkephalin biosynthesis in NG108 cells.
    Brain research, 1988, Volume: 427, Issue:2

    Topics: Animals; Cell Line; Colforsin; Enkephalin, Methionine; Enkephalins; Etorphine; Genes; Glioma; Hybrid Cells; Morphinans; Morphine; Naloxone; Neuroblastoma; Protein Precursors; RNA, Messenger; Transcription, Genetic

1988
Topological similarities between a cyclic enkephalin analogue and a potent opiate alkaloid: a computer-modeling approach.
    Journal of medicinal chemistry, 1986, Volume: 29, Issue:9

    Topics: Chemical Phenomena; Chemistry; Computers; Enkephalin, Leucine; Etorphine; Peptides, Cyclic; Protein Conformation; Structure-Activity Relationship; Thebaine

1986
Structure-activity relationships of enkephalins containing serially replaced thiomethylene amide bond surrogates.
    Life sciences, 1986, Apr-07, Volume: 38, Issue:14

    Topics: Amides; Animals; Binding, Competitive; Biological Assay; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Etorphine; Guinea Pigs; Ileum; Muscle Contraction; Structure-Activity Relationship; Thioamides

1986
Application of receptor theory provides further evidence for the existence of the epsilon-opioid receptor in rat vas deferens.
    Neuropeptides, 1984, Volume: 5, Issue:1-3

    Topics: Animals; beta-Endorphin; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Vas Deferens

1984
Kappa 3: a novel subtype of the kappa opioid site in bovine adrenal medulla, highly selective for Met-enkephalin-Arg6-Phe7.
    Neuropeptides, 1984, Volume: 5, Issue:1-3

    Topics: Adrenal Medulla; Animals; Cattle; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Etorphine; In Vitro Techniques; Narcotics; Receptors, Opioid; Receptors, Opioid, kappa

1984
Mechanisms of multiple cellular adaptation processes in clonal cell lines during chronic opiate treatment.
    NIDA research monograph, 1984, Volume: 54

    Topics: Adaptation, Physiological; Adenylyl Cyclases; Animals; Cell Line; Clone Cells; Cytosol; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Glioma; Guanylyl Imidodiphosphate; Lanthanum; Mice; Naloxone; Narcotics; Neuroblastoma; Rats; Receptors, Opioid; Sodium; Time Factors

1984
comparative study of opiate and enkephalin receptors on lower vertebrates and higher vertebrates.
    Comparative biochemistry and physiology. C: Comparative pharmacology, 1980, Volume: 67C, Issue:2

    Topics: Ambystoma; Ambystoma mexicanum; Animals; Enkephalins; Etorphine; Metamorphosis, Biological; Pleurodeles; Rats; Receptors, Opioid; Salamandridae; Species Specificity

1980
Evidence for a single opioid receptor type on the field stimulated rat vas deferens.
    Life sciences, 1981, Dec-21, Volume: 29, Issue:25

    Topics: Animals; Benzimidazoles; beta-Endorphin; Dose-Response Relationship, Drug; Electric Stimulation; Endorphins; Enkephalins; Etorphine; Fentanyl; Male; Morphine; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Sufentanil; Vas Deferens

1981
Solubilization in high yield of opioid receptors retaining high-affinity delta, mu and kappa binding sites.
    FEBS letters, 1984, May-21, Volume: 170, Issue:2

    Topics: Animals; Binding Sites; Brain Chemistry; Cell Membrane; Chemical Precipitation; Detergents; Digitonin; Drug Stability; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Magnesium; Peptide Fragments; Polyethylene Glycols; Rats; Receptors, Opioid; Solubility

1984
Opiates stimulate low Km GTPase in brain.
    Journal of neurochemistry, 1984, Volume: 43, Issue:4

    Topics: Adenylyl Cyclase Inhibitors; Animals; Brain; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Etorphine; GTP Phosphohydrolases; Guanosine Triphosphate; Male; Naloxone; Phosphoric Monoester Hydrolases; Rats; Rats, Inbred Strains; Tissue Distribution

1984
Stereospecificity of opiate-stimulated GTPase activity in brain.
    Neuropeptides, 1984, Volume: 5, Issue:1-3

    Topics: Animals; Brain; Dextrorphan; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Etorphine; GTP Phosphohydrolases; In Vitro Techniques; Levorphanol; Narcotics; Phosphoric Monoester Hydrolases; Rats; Receptors, Opioid; Stereoisomerism

1984
Mosaic distribution of opiate receptors, parafascicular projections and acetylcholinesterase in rat striatum.
    Nature, 1981, Jun-04, Volume: 291, Issue:5814

    Topics: Acetylcholinesterase; Animals; Axonal Transport; Caudate Nucleus; Corpus Striatum; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Leucine; Naloxone; Proline; Rats; Receptors, Opioid

1981
Inactivation of the opiate receptor in bovine caudate nucleus by azide enkephalin analogs.
    The Journal of biological chemistry, 1980, Aug-10, Volume: 255, Issue:15

    Topics: Affinity Labels; Animals; Azides; Binding, Competitive; Biological Assay; Cattle; Caudate Nucleus; Electric Stimulation; Endorphins; Enkephalins; Etorphine; Guinea Pigs; Ileum; Kinetics; Receptors, Opioid; Structure-Activity Relationship

1980
Opiate binding sites in the retina: properties and distribution.
    The Journal of pharmacology and experimental therapeutics, 1980, Volume: 215, Issue:1

    Topics: Animals; Binding Sites; Bufo marinus; Cattle; Cell Membrane; Enkephalin, Methionine; Enkephalins; Etorphine; Fishes; Male; Naloxone; Rats; Receptors, Opioid; Retina

1980
Selective localization of different types of opiate receptors in hippocampus as revealed by in vitro autoradiography.
    Brain research, 1981, Jan-26, Volume: 205, Issue:1

    Topics: Animals; Autoradiography; Binding Sites; Dendrites; Enkephalins; Etorphine; Hippocampus; Interneurons; Male; Neurons; Rats; Receptors, Opioid

1981
A selective distribution pattern of different opiate receptors in certain areas of rat brain as revealed by in vitro autoradiography.
    Neuroscience letters, 1981, Jan-20, Volume: 21, Issue:2

    Topics: Animals; Autoradiography; Brain; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Male; Rats; Receptors, Opioid

1981
Comparison of the anticonvulsant effects of opioid peptides and etorphine in rats after icv administration.
    Life sciences, 1981, Sep-07, Volume: 29, Issue:10

    Topics: Animals; Anticonvulsants; beta-Endorphin; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; Etorphine; Flurothyl; Male; Morphinans; Naloxone; Rats; Rats, Inbred Strains; Seizures; Structure-Activity Relationship

1981
Characterization of the dopamine stimulated adenylate cyclase in the pedal ganglia of Mytilus edulis: interactions with etorphine, beta-endorphin, DALA, and methionine enkephalin.
    Cellular and molecular neurobiology, 1981, Volume: 1, Issue:1

    Topics: Adenylyl Cyclases; Animals; beta-Endorphin; Bivalvia; Dopamine; Endorphins; Enkephalin, Methionine; Enkephalins; Etorphine; Ganglia; Kinetics; Morphinans

1981
Naltrexone-induced opiate receptor supersensitivity.
    Brain research, 1982, Aug-12, Volume: 245, Issue:2

    Topics: Animals; Brain; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Female; Guanosine Triphosphate; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid

1982
Opiate receptor-mediated inhibition of catecholamine release in primary cultures of bovine adrenal chromaffin cells.
    Journal of neurochemistry, 1982, Volume: 39, Issue:6

    Topics: Acetylcholine; Adrenal Medulla; Animals; beta-Endorphin; Catecholamines; Cattle; Cells, Cultured; Chromaffin Granules; Chromaffin System; Cyclazocine; Dihydromorphine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Phenazocine; Receptors, Opioid

1982
Evidence for multiple "Kappa" binding sites by use of opioid peptides in the guinea-pig lumbo-sacral spinal cord.
    Neuropeptides, 1982, Volume: 3, Issue:1

    Topics: Animals; Binding Sites; Cyclazocine; Dihydromorphine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Guinea Pigs; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, kappa; Spinal Cord

1982
Down regulation of enkephalin (delta) receptors. Demonstration in membrane-bound and solubilized receptors.
    Biochimica et biophysica acta, 1982, Dec-30, Volume: 721, Issue:4

    Topics: Alkaloids; Animals; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Etorphine; Glioma; Hybrid Cells; In Vitro Techniques; Morphine; Neuroblastoma; Rats; Receptors, Opioid; Solubility

1982
Multiple opiate binding sites in the central nervous system of the rabbit. Large predominance of a mu subtype in the cerebellum and characterization of a kappa subtype in the thalamus.
    Molecular pharmacology, 1983, Volume: 24, Issue:1

    Topics: Animals; Binding, Competitive; Central Nervous System; Cerebellum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; In Vitro Techniques; Membranes; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thalamus

1983
Functional opiate receptor in mouse vas deferens: evidence for a complex interaction.
    The Journal of pharmacology and experimental therapeutics, 1983, Volume: 226, Issue:3

    Topics: Animals; Arylsulfatases; beta-Endorphin; Dose-Response Relationship, Drug; Drug Interactions; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Male; Mice; Mice, Inbred ICR; Morphine; Muscle Contraction; Naloxone; Receptors, Opioid; Sulfatases; Vas Deferens

1983
Further evidence for an opioid receptor complex.
    Journal of neurobiology, 1983, Volume: 14, Issue:5

    Topics: Animals; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Etorphine; In Vitro Techniques; Rats; Receptors, Opioid

1983
A selective role for delta-receptors in the regulation of opioid-induced changes in seizure threshold.
    Life sciences, 1983, Volume: 33 Suppl 1

    Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Male; Meperidine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Seizures; Sensory Thresholds

1983
Opiate binding to subcellular fractions from guinea pig ileum.
    Life sciences, 1984, Jan-23, Volume: 34, Issue:4

    Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Guinea Pigs; Ileum; In Vitro Techniques; Receptors, Opioid; Subcellular Fractions

1984
Effect of digitonin on the binding of opiate agonists and antagonists to membrane-bound and soluble opioid binding sites.
    Brain research, 1984, Jan-23, Volume: 291, Issue:2

    Topics: Animals; Brain; Bufo marinus; Digitonin; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Male; Naloxone; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Species Specificity

1984
Chronic ethanol changes opiate receptor function in rat striatum.
    Brain research, 1984, Feb-20, Volume: 293, Issue:2

    Topics: Animals; Corpus Striatum; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Ethanol; Etorphine; Male; Rats; Receptors, Opioid

1984
Characterization and down-regulation of opiate receptors in aggregating fetal rat brain cells.
    Brain research, 1984, Jun-25, Volume: 304, Issue:2

    Topics: Animals; Brain; Cell Aggregation; Cells, Cultured; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Fetus; Molecular Conformation; Rats; Rats, Inbred Strains; Receptors, Opioid

1984
Bremazocine induces antinociception, but prevents opioid-induced constipation and catatonia in rats and precipitates withdrawal in morphine-dependent rats.
    Life sciences, 1984, Aug-27, Volume: 35, Issue:9

    Topics: Analgesics; Animals; Benzomorphans; Catatonia; Constipation; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Gastrointestinal Motility; Humans; Male; Morphinans; Morphine; Naloxone; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders

1984
Evidence for internalization of opioid peptides but not opiate drugs in brain slices.
    Proceedings of the Western Pharmacology Society, 1984, Volume: 27

    Topics: Animals; Brain; Endorphins; Enkephalins; Etorphine; Glucose; In Vitro Techniques; Male; Narcotics; Ouabain; Rats; Rats, Inbred Strains

1984
Enkephalins affect hippocampal membrane phosphorylation.
    European journal of pharmacology, 1980, Jul-25, Volume: 65, Issue:2-3

    Topics: Animals; Cell Membrane; Endorphins; Enkephalins; Etorphine; Hippocampus; In Vitro Techniques; Male; Membranes; Mitochondria; Molecular Weight; Naloxone; Phosphorylation; Rats; Synaptosomes

1980
Comparison of the binding characteristics of tritiated opiates and opioid peptides.
    British journal of pharmacology, 1980, Volume: 70, Issue:3

    Topics: Animals; Binding, Competitive; Endorphins; Enkephalins; Etorphine; Guinea Pigs; Heroin; In Vitro Techniques; Narcotic Antagonists; Narcotics; Temperature

1980
Different subtypes of opioid receptors have different affinities for G-proteins.
    Cellular and molecular biology (Noisy-le-Grand, France), 1994, Volume: 40, Issue:3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Amino Acid Sequence; Animals; Binding, Competitive; Cerebellum; Colforsin; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; GTP-Binding Proteins; Guinea Pigs; Humans; Hybrid Cells; Molecular Sequence Data; Morphine; Naloxone; Neoplasm Proteins; Nerve Tissue Proteins; Neuroblastoma; Oligopeptides; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured

1994
Stereochemical requirements for pseudoirreversible inhibition of opioid mu receptor binding by the 3-methylfentanyl congeners, RTI-46144 and its enantiomers: evidence for different binding domains.
    Synapse (New York, N.Y.), 1993, Volume: 15, Issue:4

    Topics: Animals; Binding Sites; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Fentanyl; Ligands; Molecular Conformation; Rats; Receptors, Opioid, mu; Stereoisomerism

1993
Opioid antagonist-induced receptor upregulation: effects of concurrent agonist administration.
    Brain research bulletin, 1994, Volume: 33, Issue:2

    Topics: Animals; Brain; Drug Combinations; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Fentanyl; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Up-Regulation

1994
Altered transition between agonist- and antagonist-favoring states of mu-opioid receptor in brain membranes with modified microviscosity.
    Journal of neurochemistry, 1993, Volume: 61, Issue:3

    Topics: Animals; Brain; Cholesterol Esters; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Male; Membrane Fluidity; Membranes; Naltrexone; Oleic Acid; Oleic Acids; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Sodium Chloride; Sufentanil; Viscosity

1993
Solubilization of high-affinity, guanine nucleotide-sensitive mu-opioid receptors from 7315c cell membranes.
    Journal of neurochemistry, 1993, Volume: 61, Issue:3

    Topics: Animals; Binding Sites; Binding, Competitive; Brain; Cell Membrane; Cholic Acids; Detergents; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Guanine Nucleotides; Rats; Receptors, Opioid, mu; Solubility

1993
Studies on mu and delta opioid receptor selectivity utilizing chimeric and site-mutagenized receptors.
    Proceedings of the National Academy of Sciences of the United States of America, 1995, Dec-19, Volume: 92, Issue:26

    Topics: Amino Acid Sequence; Analgesics; Base Sequence; Benzomorphans; Binding, Competitive; Cell Line; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Etorphine; GTP-Binding Proteins; Humans; Kidney; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Naloxone; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Protein Structure, Secondary; Receptors, Opioid, delta; Receptors, Opioid, mu; Recombinant Fusion Proteins; Substrate Specificity; Transfection

1995
Morphine activates opioid receptors without causing their rapid internalization.
    The Journal of biological chemistry, 1996, Aug-09, Volume: 271, Issue:32

    Topics: Cell Line; Endocytosis; Enkephalins; Etorphine; Fluorescent Antibody Technique; Humans; Morphine; Receptors, Opioid

1996
The stimulatory effect of opioids on mitogen-activated protein kinase in Chinese hamster ovary cells transfected to express mu-opioid receptors.
    Molecular pharmacology, 1996, Volume: 50, Issue:3

    Topics: Animals; Benzeneacetamides; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Etorphine; Morphine; Narcotics; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Transfection; Virulence Factors, Bordetella

1996
Lack of effect of gamma-hydroxybutyrate on mu, delta and kappa opioid receptor binding.
    Neuroscience letters, 1996, Jul-05, Volume: 212, Issue:1

    Topics: Adjuvants, Anesthesia; Analgesics; Animals; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Glioma; Guinea Pigs; Naloxone; Narcotic Antagonists; Narcotics; Neuroblastoma; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium Oxybate; Tritium; Tumor Cells, Cultured

1996
The antiproliferative effect of opioid receptor agonists on the T47D human breast cancer cell line, is partially mediated through opioid receptors.
    European journal of pharmacology, 1996, Jan-25, Volume: 296, Issue:2

    Topics: Adenocarcinoma; Amino Acid Sequence; Binding Sites; Breast Neoplasms; Cell Division; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Etorphine; Humans; Molecular Sequence Data; Morphine; Narcotic Antagonists; Opioid Peptides; Receptors, Opioid; Tumor Cells, Cultured

1996
Differential opioid agonist regulation of the mouse mu opioid receptor.
    The Journal of biological chemistry, 1997, Jan-10, Volume: 272, Issue:2

    Topics: Adenylate Cyclase Toxin; Analgesics; Animals; Buprenorphine; Colforsin; Cyclic AMP; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Levorphanol; Methadone; Mice; Morphine; Pertussis Toxin; Receptors, Opioid, mu; Virulence Factors, Bordetella

1997
Efficacy and kinetics of opioid action on acutely dissociated neurons.
    Molecular pharmacology, 1997, Volume: 52, Issue:1

    Topics: Animals; Brimonidine Tartrate; Calcium Channels; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Etorphine; Locus Coeruleus; Morphine; Narcotics; Potassium Channels; Quinoxalines

1997
Opioid regulation of the mouse delta-opioid receptor expressed in human embryonic kidney 293 cells.
    Molecular pharmacology, 1997, Volume: 52, Issue:2

    Topics: Adenylyl Cyclases; Animals; Antibodies, Monoclonal; Cell Line; Colforsin; Cyclic AMP; Down-Regulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; GTP-Binding Proteins; Humans; Methadone; Mice; Morphine; Point Mutation; Radioligand Assay; Receptors, Opioid, delta; Signal Transduction; Structure-Activity Relationship

1997
[Met]enkephalin in the spinal cord is involved in the antinociception induced by intracerebroventricularly-administered etorphine in the mouse.
    Neuroscience, 1997, Volume: 80, Issue:2

    Topics: Analgesics, Opioid; Animals; Antibodies, Blocking; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Etorphine; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Pain Measurement; Receptors, Opioid, delta; Receptors, sigma; Spinal Cord

1997
Agonist-induced signaling and trafficking of the mu-opioid receptor: role of serine and threonine residues in the third cytoplasmic loop and C-terminal domain.
    FEBS letters, 1997, Sep-29, Volume: 415, Issue:2

    Topics: Adenylyl Cyclases; Animals; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Activation; Etorphine; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Humans; Morphine; Mutagenesis, Site-Directed; Receptors, Opioid, mu; Serine; Signal Transduction; Threonine

1997
Opioid peptide receptor studies. 7. The methylfentanyl congener RTI-4614-4 and its four enantiomers bind to different domains of the rat mu opioid receptor.
    Synapse (New York, N.Y.), 1998, Volume: 28, Issue:2

    Topics: Affinity Labels; Analgesics; Analgesics, Opioid; Animals; Binding Sites; Binding, Competitive; COS Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Fentanyl; Melphalan; Membrane Proteins; Protein Structure, Tertiary; Radioligand Assay; Rats; Receptors, Opioid, mu; Recombinant Fusion Proteins; Stereoisomerism

1998
Nonselective coupling of the human mu-opioid receptor to multiple inhibitory G-protein isoforms.
    European journal of biochemistry, 1999, Volume: 261, Issue:2

    Topics: Binding Sites; Binding, Competitive; Buprenorphine; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Gene Expression; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Humans; Protein Binding; Protein Isoforms; Receptors, Opioid, mu; Recombinant Proteins; Saccharomyces cerevisiae; Spheroplasts; Transformation, Genetic

1999
Differential desensitization of human delta-opioid receptors by peptide and alkaloid agonists.
    European journal of pharmacology, 1999, Apr-29, Volume: 371, Issue:2-3

    Topics: Adenylyl Cyclase Inhibitors; Alkaloids; Analgesics; Analgesics, Opioid; Cyclic AMP; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; Humans; Naloxone; Neuroblastoma; Oligopeptides; Peptides; Receptors, Opioid, delta; Tumor Cells, Cultured

1999
Differential G-protein activation by alkaloid and peptide opioid agonists in the human neuroblastoma cell line SK-N-BE.
    The Biochemical journal, 1999, Aug-15, Volume: 342 ( Pt 1)

    Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Alkaloids; Animals; Azides; Cell Membrane; Colforsin; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; GTP-Binding Proteins; Guanosine Triphosphate; Humans; Isoelectric Point; Neuroblastoma; Neurons; Oligodeoxyribonucleotides, Antisense; Oligopeptides; Peptides; Pertussis Toxin; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Tumor Cells, Cultured; Virulence Factors, Bordetella

1999
Dissociation of functional roles of dynamin in receptor-mediated endocytosis and mitogenic signal transduction.
    The Journal of biological chemistry, 1999, Aug-27, Volume: 274, Issue:35

    Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Dynamins; Endocytosis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Activation; Etorphine; GTP Phosphohydrolases; GTP-Binding Proteins; Humans; Morphine; Phosphorylation; Receptors, Opioid; Signal Transduction; Transfection

1999
Functional dissociation of mu opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction.
    Neuron, 1999, Volume: 23, Issue:4

    Topics: Arrestin; Cell Line; Drug Tolerance; Electrophysiology; Endocytosis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Flow Cytometry; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Guanine Nucleotides; Humans; Immunohistochemistry; Ligands; Morphine; Narcotics; Opioid-Related Disorders; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Muscarinic; Receptors, Opioid, mu; Signal Transduction

1999
Agonist-specific regulation of mu-opioid receptor desensitization and recovery from desensitization.
    Molecular pharmacology, 2008, Volume: 73, Issue:4

    Topics: Analgesics, Opioid; Animals; Down-Regulation; Electrophysiology; Enkephalins; Etorphine; Fentanyl; In Vitro Techniques; Male; Naltrexone; Oxymorphone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu

2008
delta-Opioid receptor-stimulated Akt signaling in neuroblastoma x glioma (NG108-15) hybrid cells involves receptor tyrosine kinase-mediated PI3K activation.
    Experimental cell research, 2009, Jul-15, Volume: 315, Issue:12

    Topics: Cell Line, Tumor; Cell Survival; Cytoprotection; Enkephalins; Enzyme Activation; Etorphine; Glioma; Glycogen Synthase Kinase 3; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein beta Subunits; GTP-Binding Protein gamma Subunits; Humans; Hybrid Cells; Insulin-Like Growth Factor I; Neuroblastoma; Nuclear Envelope; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Transport; Proto-Oncogene Proteins c-akt; Receptor Protein-Tyrosine Kinases; Receptors, Nerve Growth Factor; Receptors, Opioid, delta; Signal Transduction; Transcriptional Activation

2009