etorphine has been researched along with enkephalin, leucine in 117 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 80 (68.38) | 18.7374 |
1990's | 35 (29.91) | 18.2507 |
2000's | 2 (1.71) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Keane, PE; Neal, H | 1 |
Coale, EH; Hein, DW; Herling, S; Valentino, RJ; Woods, JH | 1 |
Brandt, M; Glaser, T; Hamprecht, B; Klebensberger, W; Traber, J | 1 |
Blume, AJ; Finberg, JP; Shorr, J; Spector, S | 1 |
Lin, HK; Simon, EJ | 1 |
Blume, AJ | 2 |
Makman, MH; Walczak, SA; Wilkening, D | 1 |
Altstein, M; Vogel, Z | 1 |
Meunier, JC; Zajac, JM | 1 |
Felix, D; Frangi, U; Henke, H | 1 |
Chance, WT; Krynock, GM; Rosecrans, JA; White, AC | 1 |
Li, CH; Loh, HH; Tseng, LF; Wei, ET | 1 |
Barnard, EA; Demoliou-Mason, C; Richardson, A | 1 |
Elde, R; Lane, CM; Lee, NM; Loh, HH | 1 |
Edwards, RH; Evans, CJ; Keith, DE; Magendzo, K; Morrison, H | 1 |
Chang, LR; Loh, HH; Tao, PL; Tsai, CL | 1 |
DiMaio, J; Michel, A; Villeneuve, G | 1 |
Boer, HH; Leung, MK; Lundy, J; Stefano, GB; van Minnen, J | 1 |
Höllt, V; Simantov, R | 1 |
Katki, AG; Schwarz, S | 1 |
Biswas, R; Maneckjee, R; Vonderhaar, BK | 1 |
Durie, E; Michel, AD; Sharif, NA; Whiting, RL | 1 |
Klein, P; Nelson, WL; Simon, EJ; Yao, YH | 1 |
Mosberg, HI; Porreca, F; Qi, JN | 1 |
Han, JS; Wang, XJ | 1 |
Coombes, JE; Pumford, KM; Russell, JA; Sumner, BE | 1 |
Cross, AJ; Hille, C; Slater, P | 1 |
Porreca, F; Tortella, FC | 1 |
Bolger, GT; Marcus, KA; Skolnick, P; Thibou, R; Weissman, BA | 1 |
Law, PY; Loh, HH; Louie, AK; Zhan, JN | 1 |
Barnard, EA; Demoliou-Mason, CD; Wong, YH | 1 |
Cros, J; Francés, B; Meunier, JC; Porthé, G; Verrier, B | 1 |
Cox, BM; McMahon, PN; Werling, LL | 1 |
Su, TP | 1 |
Frances, B; Meunier, JC; Moisand, C | 1 |
Barnard, EA; Demoliou-Mason, CD | 3 |
Buder, M; Fuder, H; Riers, HD; Rothacher, G | 1 |
Cruciani, RA; Gainer, H; Lang, MA; Pesce, GO; Rodbard, D; Russell, JT | 1 |
Archer, S; Maneckjee, R; Michael, J; Osei-Gyimah, P; Zukin, RS | 1 |
Priestley, T; Turnbull, MJ; Wei, E | 1 |
Bunn, SJ; Hanley, MR; Wilkin, GP | 1 |
Holaday, JW; Robles, L; Tortella, FC | 1 |
Garzón, J; Herz, A; Schulz, R | 2 |
Costa, T; Gramsch, C; Herz, A; Wüster, M | 1 |
Boudouresque, F; Bourhim, N; Cantau, P; Castanas, E; Giraud, P; Oliver, C | 1 |
Richards, ML; Sadée, W; Yu, VC | 1 |
Charness, ME; Diamond, I; Querimit, LA | 1 |
Klein, C; Levy, R; Simantov, R | 1 |
Coscia, CJ; Devane, WA; Howlett, AC; Spain, JW | 1 |
Brown, SR; Cote, TE; Cox, BM; Puttfarcken, P; Werling, LL | 1 |
Brown, SR; Cox, BM; Puttfarcken, P; Werling, LL | 1 |
Greenspan, DL; Musacchio, JM | 1 |
Sadée, W; Yu, VC | 1 |
Gardner, EL; Vaysse, PJ; Zukin, RS | 1 |
Gainer, H; Lang, MA; Pesce, G; Rodbard, D; Russell, JT | 1 |
Chi, ZQ; Jin, WQ; Wu, SW | 1 |
Delay-Goyet, P; Roques, BP; Zajac, JM | 1 |
Agid, Y; Delay-Goyet, P; Javoy-Agid, F; Roques, BP; Zajac, JM | 1 |
Schwartz, JP | 1 |
Bayly, CI; DiMaio, J; Michel, A; Villeneuve, G | 1 |
Anwer, MK; Bettag, AL; Browne, B; Edwards, JV; Lahti, R; Rowell, P; Saneii, H; Spatola, AF; Von Voigtlander, P | 1 |
Bourhim, N; Cantau, P; Castanas, E; Giraud, P; Oliver, C | 1 |
Griffin, MT; Law, PY; Loh, HH | 1 |
Audigier, Y; Cros, J; Duprat, AM | 1 |
Day, AR; Freer, RJ; Liao, CS | 1 |
Franklin, PH; Hoss, W | 2 |
Herkenham, M; Pert, CB | 1 |
Koshland, DE; Smolarsky, M | 1 |
Groth, J; Hiller, JM; Howells, RD; Simon, EJ | 1 |
Duka, T; Herz, A; Schubert, P; Stoiber, R; Wüster, M | 2 |
Adler, MW; Cowan, A; Tortella, FC | 1 |
Catapane, EJ; Kream, RM; Stefano, GB | 1 |
Fitz-Syage, ML; Gardner, EL; Gintzler, AR; Sugarman, JR; Zukin, RS; Zukin, SR | 1 |
Guidotti, A; Saiani, L | 1 |
Attali, B; Audigier, Y; Cros, J; Gouardères, C; Mazarguil, H | 1 |
Baram, D; Levy, R; Simantov, R | 1 |
Kouakou, Y; Meunier, JC; Moisand, C; Puget, A | 1 |
Garzón, J; Lee, NM; Sánchez-Blázquez, P | 1 |
Rothman, R; Westfall, TC | 1 |
Cowan, A; Holaday, JW; Robles, LE; Tortella, FC | 1 |
Bradbury, WM; Cooper, JR; Glasel, JA; Reese, JH; Venn, RF | 1 |
Gioannini, TL; Hiller, JM; Itzhak, Y; Simon, EJ | 1 |
Govoni, S; Lucchi, L; Rius, RA; Trabucchi, M; Uzumaki, H | 1 |
Barg, J; Lenoir, D; Simantov, R | 1 |
Gambino, MC; Petrillo, P; Tavani, A | 1 |
LaBella, FS; Pinsky, C | 1 |
Bär, PR; Gispen, WH; Schotman, P | 1 |
Gillan, MG; Kosterlitz, HW; Paterson, SJ | 1 |
Jauzac, P; Polastron, J | 1 |
Brine, GA; Carroll, FI; Ni, Q; Partilla, JS; Rothman, RB; Stark, PA; Xu, H | 1 |
Davis, T; Duttaroy, A; Shah, S; Yoburn, BC | 1 |
Lazar, DF; Medzihradsky, F | 1 |
Cote, TE; Gosse, ME; Weems, HB | 1 |
Howells, RD; Jin, J; Shahrestanifar, M; Wang, WW | 1 |
Chu, PC; Evans, CJ; Kang, L; Keith, DE; Lissin, DV; Murray, SR; von Zastrow, M; Zaki, PA | 1 |
Chang, KJ; Li, LY | 1 |
Feigenbaum, JJ; Simantov, R | 1 |
Bakogeorgou, E; Castanas, E; Hatzoglou, A | 1 |
Blake, AD; Bot, G; Freeman, JC; Reisine, T | 1 |
Ingram, S; McCleskey, EW; Wilding, TJ; Williams, JT | 1 |
Blake, AD; Bot, G; Li, S; Reisine, T | 1 |
Tseng, LF; Xu, JY | 1 |
Bertin, B; Capeyrou, R; Corbani, M; Emorine, LJ; Lepage, JF; Riond, J | 1 |
Brine, GA; Carroll, FI; Chen, C; Lai, J; Liu-Chen, LY; Lu, YF; Partilla, JS; Porreca, F; Rice, KC; Rothman, RB; Sadee, W; Xu, H | 1 |
Emorine, LJ; Exner, T; Gaibelet, G; Liaubet, L; Masson, JM; Meilhoc, E; Nürnberg, B; Riond, J; Saves, I | 1 |
Allouche, S; Jauzac, P; Marie, N; Roussel, M | 1 |
Allouche, S; Hasbi, A; Homburger, V; Jauzac, P; Polastron, J | 1 |
von Zastrow, M; Whistler, JL | 1 |
Chu, P; Chuang, HH; Jan, LY; von Zastrow, M; Whistler, JL | 1 |
Virk, MS; Williams, JT | 1 |
Ammer, H; Eisinger, DA; Heiss, A | 1 |
117 other study(ies) available for etorphine and enkephalin, leucine
Article | Year |
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The effects of local micro injections of opiates and enkephalins into the forebrain on the electrocorticogram of the rat.
Topics: Animals; Brain; Codeine; Electroencephalography; Endorphins; Enkephalins; Etorphine; Male; Morphinans; Morphine; Naloxone; Rats; Receptors, Dopamine; Thebaine | 1978 |
Narcotic drug discriminations by rhesus monkeys and pigeons.
Topics: Animals; Columbidae; Cyclazocine; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Discrimination Learning; Dose-Response Relationship, Drug; Enkephalins; Ethylketocyclazocine; Etorphine; Hormones; Macaca; Macaca mulatta; Naltrexone; Narcotics; Phenazocine | 1979 |
Different receptors for somatostatin and opioids in neuroblastoma X glioma hybrid cells.
Topics: Animals; Binding, Competitive; Cyclic AMP; Enkephalins; Etorphine; Glioma; Hybrid Cells; Naloxone; Neuroblastoma; Neurons; Prostaglandins E; Rats; Receptors, Cell Surface; Receptors, Opioid; Somatostatin | 1977 |
Binding of the endogenous nonpeptide morphine-like compound to opiate receptors.
Topics: Animals; Binding, Competitive; Brain Chemistry; Cattle; Cell Line; Cell Membrane; Enkephalins; Etorphine; Humans; In Vitro Techniques; Morphine; Naloxone; Narcotics; Radioimmunoassay; Receptors, Opioid | 1977 |
Phospholipase A inhibition of opiate receptor binding can be reversed by albumin.
Topics: Animals; Brain; Enkephalins; Etorphine; In Vitro Techniques; Male; Naltrexone; Phospholipases; Rats; Receptors, Opioid; Serum Albumin, Bovine | 1978 |
Interaction of ligands with the opiate receptors of brain membranes: regulation by ions and nucleotides.
Topics: Animals; Brain; Enkephalins; Etorphine; Guanylyl Imidodiphosphate; Ligands; Male; Manganese; Morphine; Morphine Derivatives; Naltrexone; Rats; Receptors, Opioid; Ribonucleotides; Sodium | 1978 |
Opiate binding to membrane preparations of neuroblastoma x glioma hybrid cells NG108-15: effects of ions and nucleotides.
Topics: Cell Membrane; Cells, Cultured; Enkephalins; Etorphine; Glioma; Guanylyl Imidodiphosphate; Hybrid Cells; Magnesium; Manganese; Naloxone; Neuroblastoma; Nucleotides; Receptors, Opioid; Sodium | 1978 |
Interaction of morphine, etorphine and enkephalins with dopamine-stimulated adenylate cyclase of monkey amygdala.
Topics: Adenylyl Cyclases; Amygdala; Animals; Dopamine; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Etorphine; Freezing; Haplorhini; Macaca mulatta; Morphinans; Morphine; Naloxone; Receptors, Opioid; Stimulation, Chemical | 1979 |
The effect of puromycin on the biological activity of Leu-enkephalin.
Topics: Animals; Brain; Endorphins; Enkephalins; Etorphine; Guinea Pigs; Ileum; Kinetics; Puromycin; Rats; Receptors, Opioid | 1979 |
Cerebellar opiate receptors in lagomorphs. Demonstration, characterization and regional distribution.
Topics: Animals; Brain Mapping; Cerebellar Cortex; Cerebellum; Cricetinae; Dextrorphan; Enkephalins; Etorphine; Female; Levorphanol; Male; Mice; Morphine; Naloxone; Rabbits; Rats; Receptors, Opioid; Species Specificity | 1979 |
Opiate receptors in the pigeon optic tectum.
Topics: Animals; Columbidae; Enkephalins; Etorphine; Kinetics; Receptors, Opioid; Superior Colliculi | 1979 |
Autoanalgesia: acquisition, blockade and relationship to opiate binding.
Topics: Analgesia; Animals; Brain; Conditioning, Classical; Diazepam; Enkephalins; Etorphine; In Vitro Techniques; Male; Naltrexone; Narcotics; Rats; Reaction Time; Spinal Cord | 1979 |
Comparison of the behavioral effects of beta-endorphin and enkephalin analogs.
Topics: Animals; Behavior, Animal; Endorphins; Enkephalins; Etorphine; Male; Mice; Morphine; Motor Activity; Naloxone; Oligopeptides; Peptides; Rats | 1977 |
Guanine nucleotide-binding protein-coupled and -uncoupled states of opioid receptors and their relevance to the determination of subtypes.
Topics: Analgesics; Animals; Benzeneacetamides; Benzomorphans; Binding, Competitive; Cell Membrane; Cerebellum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Etorphine; Female; GTP-Binding Proteins; Guinea Pigs; Humans; Kinetics; Ligands; Placenta; Pregnancy; Prosencephalon; Protein Binding; Pyrrolidines; Rats; Receptors, Opioid | 1992 |
Regulation of an opioid-binding protein in NG108-15 cells parallels regulation of delta-opioid receptors.
Topics: Amino Acid Sequence; Animals; Carrier Proteins; Cell Adhesion Molecules; Cell Compartmentation; Cell Membrane; Cells, Cultured; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Fluorescent Antibody Technique; GPI-Linked Proteins; In Vitro Techniques; Membrane Glycoproteins; Molecular Sequence Data; Nerve Tissue Proteins; Neurons; Peptides; Rats; Receptors, Opioid, delta | 1992 |
Cloning of a delta opioid receptor by functional expression.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Blotting, Northern; Blotting, Southern; Cell Line; Cyclic AMP; Diprenorphine; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; Gene Expression; Humans; Kinetics; Models, Structural; Molecular Sequence Data; Naloxone; Narcotics; Protein Structure, Secondary; Receptors, Opioid, delta; Sequence Homology, Amino Acid; Transfection; Tumor Cells, Cultured | 1992 |
Chronic effect of [D-Pen2,D-Pen5]enkephalin on rat brain opioid receptors.
Topics: Analgesics; Animals; Brain Chemistry; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; In Vitro Techniques; Injections, Intraventricular; Male; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1991 |
A proposal for the molecular basis of mu and delta opiate receptor differentiation based on modeling of two types of cyclic enkephalins and a narcotic alkaloid.
Topics: Computer Graphics; Drug Design; Enkephalin, Leucine; Enkephalins; Etorphine; Models, Molecular; Molecular Structure; Peptides, Cyclic; Protein Conformation; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship; Substrate Specificity | 1991 |
Evidence for an enkephalinergic system in the nervous system of the pond snail, Lymnaea stagnalis.
Topics: Animals; Cell Membrane; Enkephalin, Leucine; Enkephalin, Methionine; Etorphine; Immune Sera; Immunohistochemistry; Kinetics; Lymnaea; Nervous System; Nervous System Physiological Phenomena; Neuropeptides; Receptors, Opioid | 1990 |
Regulation of proenkephalin A gene expression in aggregating fetal rat brain cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Action Potentials; Animals; Brain; Cell Aggregation; Dexamethasone; Enkephalins; Etorphine; Gene Expression Regulation; Naltrexone; Neurons; Potassium Chloride; Protein Precursors; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate; Veratridine | 1991 |
Effects of calcium-channel blockers (CCB) on mu and delta opioid receptors in rat brain membranes.
Topics: Animals; Brain; Calcium Channel Blockers; Calcium Channels; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; In Vitro Techniques; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1990 |
Binding of opioids to human MCF-7 breast cancer cells and their effects on growth.
Topics: Breast Neoplasms; Cell Division; Cell Line; Cell Membrane; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Estradiol; Etorphine; Female; Humans; Kinetics; Morphinans; Morphine; Receptors, Opioid; Tumor Cells, Cultured | 1990 |
Dog cerebral cortex contains mu-, delta- and kappa-opioid receptors at different densities: apparent lack of evidence for subtypes of the kappa-receptor using selective radioligands.
Topics: Animals; Cerebral Cortex; Dogs; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Species Specificity | 1990 |
Electrophilic alpha-methylene-gamma-lactone and isothiocyanate opioid ligands related to etorphine.
Topics: Chemical Phenomena; Chemistry; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Isothiocyanates; Lactones; Ligands; Magnetic Resonance Spectroscopy; Molecular Structure; Morphinans; Naloxone; Receptors, Opioid; Receptors, Opioid, mu; Spectrophotometry, Infrared; Stereoisomerism; Thebaine; Thiocyanates | 1990 |
Modulation of the potency and efficacy of mu-mediated antinociception by delta agonists in the mouse.
Topics: Analgesics; Animals; Codeine; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphinans; Morphine; Pain Measurement; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1990 |
Modification by cholecystokinin octapeptide of the binding of mu-, delta-, and kappa-opioid receptors.
Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; Kinetics; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sincalide | 1990 |
Opioid receptor subtypes in the supraoptic nucleus and posterior pituitary gland of morphine-tolerant rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Autoradiography; Benzomorphans; Binding, Competitive; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; Female; Injections, Intraventricular; Morphine; Pituitary Gland, Posterior; Plasma; Preoptic Area; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Supraoptic Nucleus | 1990 |
Subtraction autoradiography of opiate receptor subtypes in human brain.
Topics: Autoradiography; Binding Sites; Binding, Competitive; Brain; Cerebral Cortex; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Humans; Middle Aged; Naloxone; Receptors, Opioid; Subcellular Fractions | 1987 |
Differential antagonism of mu agonists by U50,488H in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Female; Male; Muscle Contraction; Muscle, Smooth; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Seizures; Urinary Bladder | 1987 |
Enhancement of [3H]DAGO1 binding to rat brain by low concentrations of monovalent cations.
Topics: Animals; Batrachotoxins; Benzomorphans; Brain Chemistry; Cations, Monovalent; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Guanine Nucleotides; Guanylyl Imidodiphosphate; In Vitro Techniques; Male; Naloxone; Rats; Receptors, Opioid; Temperature | 1987 |
Modification of opioid receptor activity by acid phosphatase in neuroblastoma x glioma NG108-15 hybrid cells.
Topics: Acid Phosphatase; Animals; Chromatography, High Pressure Liquid; Cyclic AMP; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Glioma; Guanfacine; Guanidines; Hybrid Cells; Neuroblastoma; Phenylacetates; Receptors, Opioid | 1988 |
ADP-ribosylation with pertussis toxin modulates the GTP-sensitive opioid ligand binding in digitonin-soluble extracts of rat brain membranes.
Topics: Adenosine Diphosphate Ribose; Animals; Brain; Cell Membrane; Digitonin; Electrophoresis, Polyacrylamide Gel; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; GTP-Binding Proteins; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Kinetics; Naloxone; Oligopeptides; Pertussis Toxin; Rats; Receptors, Opioid; Sodium; Solubility; Virulence Factors, Bordetella | 1988 |
The kappa-opioid receptor from human placenta: hydrodynamic characteristics and evidence for its association with a G protein.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Binding, Competitive; Centrifugation, Density Gradient; Chromatography, Gel; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Female; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Humans; Microvilli; Oligopeptides; Placenta; Pregnancy; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Sodium Chloride | 1988 |
Selective tolerance at mu and kappa opioid receptors modulating norepinephrine release in guinea pig cortex.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cerebral Cortex; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Guinea Pigs; Male; Morphine; Norepinephrine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1988 |
Further demonstration of kappa opioid binding sites in the brain: evidence for heterogeneity.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Binding Sites; Brain; Cyclazocine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Guinea Pigs; Levallorphan; Peptide Fragments; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Stereoisomerism | 1985 |
Na+ ions and Gpp(NH)p selectively inhibit agonist interactions at mu- and kappa-opioid receptor sites in rabbit and guinea-pig cerebellum membranes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Benzomorphans; Binding, Competitive; Cerebellum; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Guinea Pigs; Hydrogen-Ion Concentration; In Vitro Techniques; Naloxone; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium | 1985 |
Characterization of opioid receptor subtypes in solution.
Topics: Animals; Brain; Cations; Cell Membrane; Chemical Phenomena; Chemistry, Physical; Chromatography, Gel; Dihydromorphine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Guanylyl Imidodiphosphate; Iodoacetamide; Kinetics; Magnesium; Naloxone; Rats; Receptors, Opioid; Sodium; Solutions | 1986 |
On the opioid receptor subtype inhibiting the evoked release of 3H-noradrenaline from guinea-pig atria in vitro.
Topics: Animals; Atropine; Benzomorphans; Binding, Competitive; Corticosterone; Cyclazocine; Desipramine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Guinea Pigs; Heart Atria; In Vitro Techniques; Morphine; Myocardium; Naloxone; Norepinephrine; Peptide Fragments; Phentolamine; Receptors, Opioid; Receptors, Opioid, kappa; Synapses | 1986 |
Opioid receptors of bovine posterior pituitary neurosecretosomes are exclusively kappa.
Topics: Analgesics, Opioid; Animals; Cattle; Cyclazocine; Cytoplasmic Granules; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Kinetics; Morphinans; Pituitary Gland, Posterior; Receptors, Opioid; Receptors, Opioid, kappa | 1986 |
Purification and characterization of the mu opiate receptor from rat brain using affinity chromatography.
Topics: Animals; Brain Chemistry; Cholic Acids; Chromatography, Affinity; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Kinetics; Male; Molecular Weight; Protease Inhibitors; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1985 |
In vivo evidence for the selectivity of ICI 154129 for the delta-opioid receptor.
Topics: Analgesics; Animals; Enkephalin, Leucine; Etorphine; Female; Humans; Mice; Mice, Inbred C57BL; Morphine Dependence; Motor Activity; Rats; Receptors, Opioid; Receptors, Opioid, delta | 1985 |
Evidence for a kappa-opioid receptor on pituitary astrocytes: an autoradiographic study.
Topics: Animals; Astrocytes; Autoradiography; Binding Sites; Binding, Competitive; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Etorphine; Pituitary Gland; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1985 |
The anticonvulsant effects of DADLE are primarily mediated by activation of delta opioid receptors: interactions between delta and mu receptor antagonists.
Topics: Animals; Anticonvulsants; Cerebral Ventricles; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Seizures | 1985 |
Evidence for the epsilon-type of opioid receptor in the rat vas deferens.
Topics: Animals; Binding, Competitive; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Drug Synergism; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Etorphine; Fentanyl; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Vas Deferens | 1985 |
Multiple states of opioid receptors may modulate adenylate cyclase in intact neuroblastoma X glioma hybrid cells.
Topics: Adenylyl Cyclases; Animals; Cell Line; Cyclic AMP; Diprenorphine; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Glioma; Hybrid Cells; Kinetics; Ligands; Morphine; Naloxone; Neuroblastoma; Neurons; Receptors, Opioid; Receptors, Opioid, delta | 1985 |
Interaction of opiates with opioid binding sites in the bovine adrenal medulla: II. Interaction with kappa sites.
Topics: Adrenal Medulla; Animals; Benzomorphans; Binding Sites; Calcium; Cattle; Cyclazocine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Ethylketocyclazocine; Ethylmaleimide; Etorphine; Guinea Pigs; Kinetics; Lithium; Manganese; Narcotics; Oligopeptides; Phospholipases A; Potassium; Receptors, Opioid; Receptors, Opioid, kappa; Sodium; Stereoisomerism | 1985 |
A human neuroblastoma cell line expresses mu and delta opioid receptor sites.
Topics: Bone Neoplasms; Cell Line; Child, Preschool; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Female; Guanylyl Imidodiphosphate; Humans; Kinetics; Naloxone; Neuroblastoma; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sodium Chloride | 1986 |
Ethanol increases the expression of functional delta-opioid receptors in neuroblastoma x glioma NG108-15 hybrid cells.
Topics: Cell Line; Cyclic AMP; Cycloheximide; Dactinomycin; Diprenorphine; DNA; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethanol; Etorphine; Glioma; Hybridomas; Naloxone; Neuroblastoma; Phenylisopropyladenosine; Receptors, Opioid; Receptors, Opioid, delta; Sodium; Transcription, Genetic | 1986 |
Distinct subtypes of the opioid receptor with allosteric interactions in brain membranes.
Topics: Allosteric Site; Animals; Brain; Cations; Cell Membrane; Dihydromorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Guanylyl Imidodiphosphate; Kinetics; Magnesium; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Sodium | 1986 |
Subcellular compartmentation of opioid receptors: modulation by enkephalin and alkaloids.
Topics: Animals; Cell Line; Cell Membrane; Centrifugation, Density Gradient; Chloroquine; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Glioma; Golgi Apparatus; Kinetics; Lysosomes; Microsomes; Neuroblastoma; Receptors, Opioid | 1986 |
An assessment of the role of opioid receptors in the response to cannabimimetic drugs.
Topics: Adenylyl Cyclase Inhibitors; Animals; Cannabinoids; Cell Line; Dronabinol; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Etorphine; Morphine; Naltrexone; Neuroblastoma; Neurons; Receptors, Opioid; Receptors, Opioid, delta | 1986 |
Sodium regulation of agonist binding at opioid receptors. I. Effects of sodium replacement on binding at mu- and delta-type receptors in 7315c and NG108-15 cells and cell membranes.
Topics: Adenylyl Cyclase Inhibitors; Animals; Cell Line; Cell Membrane; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Etorphine; Glioma; Guinea Pigs; Monensin; Naloxone; Neuroblastoma; Pituitary Neoplasms; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sodium | 1986 |
Sodium regulation of agonist binding at opioid receptors. II. Effects of sodium replacement on opioid binding in guinea pig cortical membranes.
Topics: Animals; Cell Membrane; Cerebral Cortex; Cyclazocine; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Etorphine; Guinea Pigs; Male; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium | 1986 |
The adenylate cyclase rebound response to naloxone in the NG108-15 cells. Effects of etorphine and other opiates.
Topics: Adenylyl Cyclases; Alprostadil; Cell Line; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Etorphine; Glioma; Morphinans; Morphine; Naloxone; Neuroblastoma; Receptors, Opioid | 1986 |
Phosphatidylinositol turnover in neuroblastoma cells: regulation by bradykinin, acetylcholine, but not mu- and delta-opioid receptors.
Topics: Acetylcholine; Animals; Bradykinin; Cell Line; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Mice; Phosphatidylinositols; Rats; Receptors, Opioid | 1986 |
Modulation of rat brain opioid receptors by cannabinoids.
Topics: Animals; Cannabinoids; Cyclazocine; Dihydromorphine; Dose-Response Relationship, Drug; Dronabinol; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Etorphine; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Spiperone | 1987 |
Characterization of kappa opioid receptors in neurosecretosomes from bovine posterior pituitary.
Topics: Animals; Cattle; Cytoplasmic Granules; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Kinetics; Microscopy, Electron; Pituitary Gland, Posterior; Receptors, Opioid; Receptors, Opioid, kappa | 1987 |
[Characterization of opioid receptors in the golden hamster brain].
Topics: Animals; Binding, Competitive; Brain; Brain Chemistry; Cricetinae; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Female; Male; Mesocricetus; Radioligand Assay; Receptors, Opioid | 1986 |
Differences of binding characteristics of non-selective opiates towards mu and delta receptor types.
Topics: Animals; Binding, Competitive; Brain; Cell Membrane; Cerebellum; Cyclazocine; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethylketocyclazocine; Etorphine; Male; Oligopeptides; Rabbits; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1987 |
Regional distribution of mu, delta and kappa opioid receptors in human brains from controls and parkinsonian subjects.
Topics: Aged; Aged, 80 and over; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Humans; Kinetics; Oligopeptides; Parkinson Disease; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1987 |
Chronic exposure to opiate agonists increases proenkephalin biosynthesis in NG108 cells.
Topics: Animals; Cell Line; Colforsin; Enkephalin, Methionine; Enkephalins; Etorphine; Genes; Glioma; Hybrid Cells; Morphinans; Morphine; Naloxone; Neuroblastoma; Protein Precursors; RNA, Messenger; Transcription, Genetic | 1988 |
Topological similarities between a cyclic enkephalin analogue and a potent opiate alkaloid: a computer-modeling approach.
Topics: Chemical Phenomena; Chemistry; Computers; Enkephalin, Leucine; Etorphine; Peptides, Cyclic; Protein Conformation; Structure-Activity Relationship; Thebaine | 1986 |
Structure-activity relationships of enkephalins containing serially replaced thiomethylene amide bond surrogates.
Topics: Amides; Animals; Binding, Competitive; Biological Assay; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Etorphine; Guinea Pigs; Ileum; Muscle Contraction; Structure-Activity Relationship; Thioamides | 1986 |
Application of receptor theory provides further evidence for the existence of the epsilon-opioid receptor in rat vas deferens.
Topics: Animals; beta-Endorphin; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Vas Deferens | 1984 |
Kappa 3: a novel subtype of the kappa opioid site in bovine adrenal medulla, highly selective for Met-enkephalin-Arg6-Phe7.
Topics: Adrenal Medulla; Animals; Cattle; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Etorphine; In Vitro Techniques; Narcotics; Receptors, Opioid; Receptors, Opioid, kappa | 1984 |
Mechanisms of multiple cellular adaptation processes in clonal cell lines during chronic opiate treatment.
Topics: Adaptation, Physiological; Adenylyl Cyclases; Animals; Cell Line; Clone Cells; Cytosol; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Glioma; Guanylyl Imidodiphosphate; Lanthanum; Mice; Naloxone; Narcotics; Neuroblastoma; Rats; Receptors, Opioid; Sodium; Time Factors | 1984 |
comparative study of opiate and enkephalin receptors on lower vertebrates and higher vertebrates.
Topics: Ambystoma; Ambystoma mexicanum; Animals; Enkephalins; Etorphine; Metamorphosis, Biological; Pleurodeles; Rats; Receptors, Opioid; Salamandridae; Species Specificity | 1980 |
Evidence for a single opioid receptor type on the field stimulated rat vas deferens.
Topics: Animals; Benzimidazoles; beta-Endorphin; Dose-Response Relationship, Drug; Electric Stimulation; Endorphins; Enkephalins; Etorphine; Fentanyl; Male; Morphine; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Sufentanil; Vas Deferens | 1981 |
Solubilization in high yield of opioid receptors retaining high-affinity delta, mu and kappa binding sites.
Topics: Animals; Binding Sites; Brain Chemistry; Cell Membrane; Chemical Precipitation; Detergents; Digitonin; Drug Stability; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Magnesium; Peptide Fragments; Polyethylene Glycols; Rats; Receptors, Opioid; Solubility | 1984 |
Opiates stimulate low Km GTPase in brain.
Topics: Adenylyl Cyclase Inhibitors; Animals; Brain; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Etorphine; GTP Phosphohydrolases; Guanosine Triphosphate; Male; Naloxone; Phosphoric Monoester Hydrolases; Rats; Rats, Inbred Strains; Tissue Distribution | 1984 |
Stereospecificity of opiate-stimulated GTPase activity in brain.
Topics: Animals; Brain; Dextrorphan; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Etorphine; GTP Phosphohydrolases; In Vitro Techniques; Levorphanol; Narcotics; Phosphoric Monoester Hydrolases; Rats; Receptors, Opioid; Stereoisomerism | 1984 |
Mosaic distribution of opiate receptors, parafascicular projections and acetylcholinesterase in rat striatum.
Topics: Acetylcholinesterase; Animals; Axonal Transport; Caudate Nucleus; Corpus Striatum; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Leucine; Naloxone; Proline; Rats; Receptors, Opioid | 1981 |
Inactivation of the opiate receptor in bovine caudate nucleus by azide enkephalin analogs.
Topics: Affinity Labels; Animals; Azides; Binding, Competitive; Biological Assay; Cattle; Caudate Nucleus; Electric Stimulation; Endorphins; Enkephalins; Etorphine; Guinea Pigs; Ileum; Kinetics; Receptors, Opioid; Structure-Activity Relationship | 1980 |
Opiate binding sites in the retina: properties and distribution.
Topics: Animals; Binding Sites; Bufo marinus; Cattle; Cell Membrane; Enkephalin, Methionine; Enkephalins; Etorphine; Fishes; Male; Naloxone; Rats; Receptors, Opioid; Retina | 1980 |
Selective localization of different types of opiate receptors in hippocampus as revealed by in vitro autoradiography.
Topics: Animals; Autoradiography; Binding Sites; Dendrites; Enkephalins; Etorphine; Hippocampus; Interneurons; Male; Neurons; Rats; Receptors, Opioid | 1981 |
A selective distribution pattern of different opiate receptors in certain areas of rat brain as revealed by in vitro autoradiography.
Topics: Animals; Autoradiography; Brain; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Male; Rats; Receptors, Opioid | 1981 |
Comparison of the anticonvulsant effects of opioid peptides and etorphine in rats after icv administration.
Topics: Animals; Anticonvulsants; beta-Endorphin; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; Etorphine; Flurothyl; Male; Morphinans; Naloxone; Rats; Rats, Inbred Strains; Seizures; Structure-Activity Relationship | 1981 |
Characterization of the dopamine stimulated adenylate cyclase in the pedal ganglia of Mytilus edulis: interactions with etorphine, beta-endorphin, DALA, and methionine enkephalin.
Topics: Adenylyl Cyclases; Animals; beta-Endorphin; Bivalvia; Dopamine; Endorphins; Enkephalin, Methionine; Enkephalins; Etorphine; Ganglia; Kinetics; Morphinans | 1981 |
Naltrexone-induced opiate receptor supersensitivity.
Topics: Animals; Brain; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Female; Guanosine Triphosphate; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1982 |
Opiate receptor-mediated inhibition of catecholamine release in primary cultures of bovine adrenal chromaffin cells.
Topics: Acetylcholine; Adrenal Medulla; Animals; beta-Endorphin; Catecholamines; Cattle; Cells, Cultured; Chromaffin Granules; Chromaffin System; Cyclazocine; Dihydromorphine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Phenazocine; Receptors, Opioid | 1982 |
Evidence for multiple "Kappa" binding sites by use of opioid peptides in the guinea-pig lumbo-sacral spinal cord.
Topics: Animals; Binding Sites; Cyclazocine; Dihydromorphine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Guinea Pigs; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, kappa; Spinal Cord | 1982 |
Down regulation of enkephalin (delta) receptors. Demonstration in membrane-bound and solubilized receptors.
Topics: Alkaloids; Animals; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Etorphine; Glioma; Hybrid Cells; In Vitro Techniques; Morphine; Neuroblastoma; Rats; Receptors, Opioid; Solubility | 1982 |
Multiple opiate binding sites in the central nervous system of the rabbit. Large predominance of a mu subtype in the cerebellum and characterization of a kappa subtype in the thalamus.
Topics: Animals; Binding, Competitive; Central Nervous System; Cerebellum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; In Vitro Techniques; Membranes; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thalamus | 1983 |
Functional opiate receptor in mouse vas deferens: evidence for a complex interaction.
Topics: Animals; Arylsulfatases; beta-Endorphin; Dose-Response Relationship, Drug; Drug Interactions; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Male; Mice; Mice, Inbred ICR; Morphine; Muscle Contraction; Naloxone; Receptors, Opioid; Sulfatases; Vas Deferens | 1983 |
Further evidence for an opioid receptor complex.
Topics: Animals; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Etorphine; In Vitro Techniques; Rats; Receptors, Opioid | 1983 |
A selective role for delta-receptors in the regulation of opioid-induced changes in seizure threshold.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Male; Meperidine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Seizures; Sensory Thresholds | 1983 |
Opiate binding to subcellular fractions from guinea pig ileum.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Guinea Pigs; Ileum; In Vitro Techniques; Receptors, Opioid; Subcellular Fractions | 1984 |
Effect of digitonin on the binding of opiate agonists and antagonists to membrane-bound and soluble opioid binding sites.
Topics: Animals; Brain; Bufo marinus; Digitonin; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Male; Naloxone; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Species Specificity | 1984 |
Chronic ethanol changes opiate receptor function in rat striatum.
Topics: Animals; Corpus Striatum; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Ethanol; Etorphine; Male; Rats; Receptors, Opioid | 1984 |
Characterization and down-regulation of opiate receptors in aggregating fetal rat brain cells.
Topics: Animals; Brain; Cell Aggregation; Cells, Cultured; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Fetus; Molecular Conformation; Rats; Rats, Inbred Strains; Receptors, Opioid | 1984 |
Bremazocine induces antinociception, but prevents opioid-induced constipation and catatonia in rats and precipitates withdrawal in morphine-dependent rats.
Topics: Analgesics; Animals; Benzomorphans; Catatonia; Constipation; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Gastrointestinal Motility; Humans; Male; Morphinans; Morphine; Naloxone; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders | 1984 |
Evidence for internalization of opioid peptides but not opiate drugs in brain slices.
Topics: Animals; Brain; Endorphins; Enkephalins; Etorphine; Glucose; In Vitro Techniques; Male; Narcotics; Ouabain; Rats; Rats, Inbred Strains | 1984 |
Enkephalins affect hippocampal membrane phosphorylation.
Topics: Animals; Cell Membrane; Endorphins; Enkephalins; Etorphine; Hippocampus; In Vitro Techniques; Male; Membranes; Mitochondria; Molecular Weight; Naloxone; Phosphorylation; Rats; Synaptosomes | 1980 |
Comparison of the binding characteristics of tritiated opiates and opioid peptides.
Topics: Animals; Binding, Competitive; Endorphins; Enkephalins; Etorphine; Guinea Pigs; Heroin; In Vitro Techniques; Narcotic Antagonists; Narcotics; Temperature | 1980 |
Different subtypes of opioid receptors have different affinities for G-proteins.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Amino Acid Sequence; Animals; Binding, Competitive; Cerebellum; Colforsin; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; GTP-Binding Proteins; Guinea Pigs; Humans; Hybrid Cells; Molecular Sequence Data; Morphine; Naloxone; Neoplasm Proteins; Nerve Tissue Proteins; Neuroblastoma; Oligopeptides; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured | 1994 |
Stereochemical requirements for pseudoirreversible inhibition of opioid mu receptor binding by the 3-methylfentanyl congeners, RTI-46144 and its enantiomers: evidence for different binding domains.
Topics: Animals; Binding Sites; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Fentanyl; Ligands; Molecular Conformation; Rats; Receptors, Opioid, mu; Stereoisomerism | 1993 |
Opioid antagonist-induced receptor upregulation: effects of concurrent agonist administration.
Topics: Animals; Brain; Drug Combinations; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Fentanyl; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Up-Regulation | 1994 |
Altered transition between agonist- and antagonist-favoring states of mu-opioid receptor in brain membranes with modified microviscosity.
Topics: Animals; Brain; Cholesterol Esters; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Male; Membrane Fluidity; Membranes; Naltrexone; Oleic Acid; Oleic Acids; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Sodium Chloride; Sufentanil; Viscosity | 1993 |
Solubilization of high-affinity, guanine nucleotide-sensitive mu-opioid receptors from 7315c cell membranes.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Cell Membrane; Cholic Acids; Detergents; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Guanine Nucleotides; Rats; Receptors, Opioid, mu; Solubility | 1993 |
Studies on mu and delta opioid receptor selectivity utilizing chimeric and site-mutagenized receptors.
Topics: Amino Acid Sequence; Analgesics; Base Sequence; Benzomorphans; Binding, Competitive; Cell Line; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Etorphine; GTP-Binding Proteins; Humans; Kidney; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Naloxone; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Protein Structure, Secondary; Receptors, Opioid, delta; Receptors, Opioid, mu; Recombinant Fusion Proteins; Substrate Specificity; Transfection | 1995 |
Morphine activates opioid receptors without causing their rapid internalization.
Topics: Cell Line; Endocytosis; Enkephalins; Etorphine; Fluorescent Antibody Technique; Humans; Morphine; Receptors, Opioid | 1996 |
The stimulatory effect of opioids on mitogen-activated protein kinase in Chinese hamster ovary cells transfected to express mu-opioid receptors.
Topics: Animals; Benzeneacetamides; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Etorphine; Morphine; Narcotics; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Transfection; Virulence Factors, Bordetella | 1996 |
Lack of effect of gamma-hydroxybutyrate on mu, delta and kappa opioid receptor binding.
Topics: Adjuvants, Anesthesia; Analgesics; Animals; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Glioma; Guinea Pigs; Naloxone; Narcotic Antagonists; Narcotics; Neuroblastoma; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium Oxybate; Tritium; Tumor Cells, Cultured | 1996 |
The antiproliferative effect of opioid receptor agonists on the T47D human breast cancer cell line, is partially mediated through opioid receptors.
Topics: Adenocarcinoma; Amino Acid Sequence; Binding Sites; Breast Neoplasms; Cell Division; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Etorphine; Humans; Molecular Sequence Data; Morphine; Narcotic Antagonists; Opioid Peptides; Receptors, Opioid; Tumor Cells, Cultured | 1996 |
Differential opioid agonist regulation of the mouse mu opioid receptor.
Topics: Adenylate Cyclase Toxin; Analgesics; Animals; Buprenorphine; Colforsin; Cyclic AMP; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Levorphanol; Methadone; Mice; Morphine; Pertussis Toxin; Receptors, Opioid, mu; Virulence Factors, Bordetella | 1997 |
Efficacy and kinetics of opioid action on acutely dissociated neurons.
Topics: Animals; Brimonidine Tartrate; Calcium Channels; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Etorphine; Locus Coeruleus; Morphine; Narcotics; Potassium Channels; Quinoxalines | 1997 |
Opioid regulation of the mouse delta-opioid receptor expressed in human embryonic kidney 293 cells.
Topics: Adenylyl Cyclases; Animals; Antibodies, Monoclonal; Cell Line; Colforsin; Cyclic AMP; Down-Regulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; GTP-Binding Proteins; Humans; Methadone; Mice; Morphine; Point Mutation; Radioligand Assay; Receptors, Opioid, delta; Signal Transduction; Structure-Activity Relationship | 1997 |
[Met]enkephalin in the spinal cord is involved in the antinociception induced by intracerebroventricularly-administered etorphine in the mouse.
Topics: Analgesics, Opioid; Animals; Antibodies, Blocking; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Etorphine; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Pain Measurement; Receptors, Opioid, delta; Receptors, sigma; Spinal Cord | 1997 |
Agonist-induced signaling and trafficking of the mu-opioid receptor: role of serine and threonine residues in the third cytoplasmic loop and C-terminal domain.
Topics: Adenylyl Cyclases; Animals; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Activation; Etorphine; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Humans; Morphine; Mutagenesis, Site-Directed; Receptors, Opioid, mu; Serine; Signal Transduction; Threonine | 1997 |
Opioid peptide receptor studies. 7. The methylfentanyl congener RTI-4614-4 and its four enantiomers bind to different domains of the rat mu opioid receptor.
Topics: Affinity Labels; Analgesics; Analgesics, Opioid; Animals; Binding Sites; Binding, Competitive; COS Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Fentanyl; Melphalan; Membrane Proteins; Protein Structure, Tertiary; Radioligand Assay; Rats; Receptors, Opioid, mu; Recombinant Fusion Proteins; Stereoisomerism | 1998 |
Nonselective coupling of the human mu-opioid receptor to multiple inhibitory G-protein isoforms.
Topics: Binding Sites; Binding, Competitive; Buprenorphine; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Gene Expression; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Humans; Protein Binding; Protein Isoforms; Receptors, Opioid, mu; Recombinant Proteins; Saccharomyces cerevisiae; Spheroplasts; Transformation, Genetic | 1999 |
Differential desensitization of human delta-opioid receptors by peptide and alkaloid agonists.
Topics: Adenylyl Cyclase Inhibitors; Alkaloids; Analgesics; Analgesics, Opioid; Cyclic AMP; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; Humans; Naloxone; Neuroblastoma; Oligopeptides; Peptides; Receptors, Opioid, delta; Tumor Cells, Cultured | 1999 |
Differential G-protein activation by alkaloid and peptide opioid agonists in the human neuroblastoma cell line SK-N-BE.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Alkaloids; Animals; Azides; Cell Membrane; Colforsin; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; GTP-Binding Proteins; Guanosine Triphosphate; Humans; Isoelectric Point; Neuroblastoma; Neurons; Oligodeoxyribonucleotides, Antisense; Oligopeptides; Peptides; Pertussis Toxin; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1999 |
Dissociation of functional roles of dynamin in receptor-mediated endocytosis and mitogenic signal transduction.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Dynamins; Endocytosis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Activation; Etorphine; GTP Phosphohydrolases; GTP-Binding Proteins; Humans; Morphine; Phosphorylation; Receptors, Opioid; Signal Transduction; Transfection | 1999 |
Functional dissociation of mu opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction.
Topics: Arrestin; Cell Line; Drug Tolerance; Electrophysiology; Endocytosis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Flow Cytometry; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Guanine Nucleotides; Humans; Immunohistochemistry; Ligands; Morphine; Narcotics; Opioid-Related Disorders; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Muscarinic; Receptors, Opioid, mu; Signal Transduction | 1999 |
Agonist-specific regulation of mu-opioid receptor desensitization and recovery from desensitization.
Topics: Analgesics, Opioid; Animals; Down-Regulation; Electrophysiology; Enkephalins; Etorphine; Fentanyl; In Vitro Techniques; Male; Naltrexone; Oxymorphone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 2008 |
delta-Opioid receptor-stimulated Akt signaling in neuroblastoma x glioma (NG108-15) hybrid cells involves receptor tyrosine kinase-mediated PI3K activation.
Topics: Cell Line, Tumor; Cell Survival; Cytoprotection; Enkephalins; Enzyme Activation; Etorphine; Glioma; Glycogen Synthase Kinase 3; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein beta Subunits; GTP-Binding Protein gamma Subunits; Humans; Hybrid Cells; Insulin-Like Growth Factor I; Neuroblastoma; Nuclear Envelope; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Transport; Proto-Oncogene Proteins c-akt; Receptor Protein-Tyrosine Kinases; Receptors, Nerve Growth Factor; Receptors, Opioid, delta; Signal Transduction; Transcriptional Activation | 2009 |