etorphine has been researched along with enkephalin, ala(2)-mephe(4)-gly(5)- in 56 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (30.36) | 18.7374 |
| 1990's | 23 (41.07) | 18.2507 |
| 2000's | 13 (23.21) | 29.6817 |
| 2010's | 3 (5.36) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barnard, EA; Demoliou-Mason, C; Richardson, A | 1 |
| Chang, LR; Loh, HH; Tao, PL; Tsai, CL | 1 |
| Katki, AG; Schwarz, S | 1 |
| Durie, E; Michel, AD; Sharif, NA; Whiting, RL | 1 |
| Klein, P; Nelson, WL; Simon, EJ; Yao, YH | 1 |
| Han, JS; Wang, XJ | 1 |
| Cross, AJ; Hille, C; Slater, P | 1 |
| Porreca, F; Tortella, FC | 1 |
| Bolger, GT; Marcus, KA; Skolnick, P; Thibou, R; Weissman, BA | 1 |
| Cros, J; Francés, B; Meunier, JC; Porthé, G; Verrier, B | 1 |
| Cox, BM; McMahon, PN; Werling, LL | 1 |
| Frances, B; Meunier, JC; Moisand, C | 1 |
| Bunn, SJ; Hanley, MR; Wilkin, GP | 1 |
| Richards, ML; Sadée, W; Yu, VC | 1 |
| Barnard, EA; Demoliou-Mason, CD | 1 |
| Brown, SR; Cote, TE; Cox, BM; Puttfarcken, P; Werling, LL | 1 |
| Brown, SR; Cox, BM; Puttfarcken, P; Werling, LL | 1 |
| Sadée, W; Yu, VC | 1 |
| Chi, ZQ; Jin, WQ; Wu, SW | 1 |
| Delay-Goyet, P; Roques, BP; Zajac, JM | 1 |
| Agid, Y; Delay-Goyet, P; Javoy-Agid, F; Roques, BP; Zajac, JM | 1 |
| Franklin, PH; Hoss, W | 1 |
| Kouakou, Y; Meunier, JC; Moisand, C; Puget, A | 1 |
| Jauzac, P; Polastron, J | 1 |
| Brine, GA; Carroll, FI; Ni, Q; Partilla, JS; Rothman, RB; Stark, PA; Xu, H | 1 |
| Davis, T; Duttaroy, A; Shah, S; Yoburn, BC | 1 |
| Lazar, DF; Medzihradsky, F | 1 |
| Cote, TE; Gosse, ME; Weems, HB | 1 |
| Howells, RD; Jin, J; Shahrestanifar, M; Wang, WW | 1 |
| Chang, KJ; Li, LY | 1 |
| Feigenbaum, JJ; Simantov, R | 1 |
| Bakogeorgou, E; Castanas, E; Hatzoglou, A | 1 |
| Blake, AD; Bot, G; Freeman, JC; Reisine, T | 1 |
| Ingram, S; McCleskey, EW; Wilding, TJ; Williams, JT | 1 |
| Bertin, B; Capeyrou, R; Corbani, M; Emorine, LJ; Lepage, JF; Riond, J | 1 |
| Brine, GA; Carroll, FI; Chen, C; Lai, J; Liu-Chen, LY; Lu, YF; Partilla, JS; Porreca, F; Rice, KC; Rothman, RB; Sadee, W; Xu, H | 1 |
| Emorine, LJ; Exner, T; Gaibelet, G; Liaubet, L; Masson, JM; Meilhoc, E; Nürnberg, B; Riond, J; Saves, I | 1 |
| von Zastrow, M; Whistler, JL | 1 |
| Chu, P; Chuang, HH; Jan, LY; von Zastrow, M; Whistler, JL | 1 |
| Akil, H; Lee, KO; Traynor, JR; Woods, JH | 1 |
| Sarne, Y; Shapira, M; Vogel, Z | 1 |
| Benedict Gomes, A; Gallagher, A; Shen, J; Stafford, K; Yoburn, BC | 1 |
| Patel, CN; Patel, MB; Rajashekara, V; Yoburn, BC | 1 |
| Sterious, SN; Walker, EA | 1 |
| David Clark, J; Demirci, H; Gharagozlou, P; Lameh, J | 1 |
| McLaughlin, PJ; Zagon, IS | 1 |
| Patel, K; Purohit, V; Yoburn, BC; Zhang, Q | 1 |
| Miyatake, M; Nakamura, A; Narita, M; Niikura, K; Suzuki, M; Suzuki, T; Yajima, Y | 1 |
| Grigoriants, OO; Law, PY; Liao, D; Loh, HH | 1 |
| Bar-Josef, H; Gafni, M; Keren, O; Korzh, A; Sarne, Y | 1 |
| Binyaminy, B; Gafni, M; Sarne, Y; Shapira, M | 1 |
| Arttamangkul, S; Low, MJ; Pintar, J; Quillinan, N; von Zastrow, M; Williams, JT | 1 |
| Benaderet, TS; Bishop-Mathis, K; Dersch, CM; Partilla, JS; Prisinzano, TE; Rothman, RB; Simpson, DS; Wang, X; Xu, H | 1 |
| Chu, J; Law, PY; Loh, HH; Zhang, Y; Zheng, H | 1 |
| Akbarali, HI; Dewey, WL; Maguma, HT | 1 |
| Barbier, E; Bi, GH; Chiu, YT; Feng, B; He, Y; Liu-Chen, LY; Wang, JB; Wang, XF; Xi, ZX; Zhan, J; Zhang, HY | 1 |
56 other study(ies) available for etorphine and enkephalin, ala(2)-mephe(4)-gly(5)-
| Article | Year |
|---|---|
Guanine nucleotide-binding protein-coupled and -uncoupled states of opioid receptors and their relevance to the determination of subtypes.
Topics: Analgesics; Animals; Benzeneacetamides; Benzomorphans; Binding, Competitive; Cell Membrane; Cerebellum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Etorphine; Female; GTP-Binding Proteins; Guinea Pigs; Humans; Kinetics; Ligands; Placenta; Pregnancy; Prosencephalon; Protein Binding; Pyrrolidines; Rats; Receptors, Opioid | 1992 |
Chronic effect of [D-Pen2,D-Pen5]enkephalin on rat brain opioid receptors.
Topics: Analgesics; Animals; Brain Chemistry; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; In Vitro Techniques; Injections, Intraventricular; Male; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1991 |
Effects of calcium-channel blockers (CCB) on mu and delta opioid receptors in rat brain membranes.
Topics: Animals; Brain; Calcium Channel Blockers; Calcium Channels; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; In Vitro Techniques; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1990 |
Dog cerebral cortex contains mu-, delta- and kappa-opioid receptors at different densities: apparent lack of evidence for subtypes of the kappa-receptor using selective radioligands.
Topics: Animals; Cerebral Cortex; Dogs; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Species Specificity | 1990 |
Electrophilic alpha-methylene-gamma-lactone and isothiocyanate opioid ligands related to etorphine.
Topics: Chemical Phenomena; Chemistry; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Isothiocyanates; Lactones; Ligands; Magnetic Resonance Spectroscopy; Molecular Structure; Morphinans; Naloxone; Receptors, Opioid; Receptors, Opioid, mu; Spectrophotometry, Infrared; Stereoisomerism; Thebaine; Thiocyanates | 1990 |
Modification by cholecystokinin octapeptide of the binding of mu-, delta-, and kappa-opioid receptors.
Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; Kinetics; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sincalide | 1990 |
Subtraction autoradiography of opiate receptor subtypes in human brain.
Topics: Autoradiography; Binding Sites; Binding, Competitive; Brain; Cerebral Cortex; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Humans; Middle Aged; Naloxone; Receptors, Opioid; Subcellular Fractions | 1987 |
Differential antagonism of mu agonists by U50,488H in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Female; Male; Muscle Contraction; Muscle, Smooth; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Seizures; Urinary Bladder | 1987 |
Enhancement of [3H]DAGO1 binding to rat brain by low concentrations of monovalent cations.
Topics: Animals; Batrachotoxins; Benzomorphans; Brain Chemistry; Cations, Monovalent; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Guanine Nucleotides; Guanylyl Imidodiphosphate; In Vitro Techniques; Male; Naloxone; Rats; Receptors, Opioid; Temperature | 1987 |
The kappa-opioid receptor from human placenta: hydrodynamic characteristics and evidence for its association with a G protein.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Binding, Competitive; Centrifugation, Density Gradient; Chromatography, Gel; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Female; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Humans; Microvilli; Oligopeptides; Placenta; Pregnancy; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Sodium Chloride | 1988 |
Selective tolerance at mu and kappa opioid receptors modulating norepinephrine release in guinea pig cortex.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cerebral Cortex; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Guinea Pigs; Male; Morphine; Norepinephrine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1988 |
Na+ ions and Gpp(NH)p selectively inhibit agonist interactions at mu- and kappa-opioid receptor sites in rabbit and guinea-pig cerebellum membranes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Benzomorphans; Binding, Competitive; Cerebellum; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Guinea Pigs; Hydrogen-Ion Concentration; In Vitro Techniques; Naloxone; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium | 1985 |
Evidence for a kappa-opioid receptor on pituitary astrocytes: an autoradiographic study.
Topics: Animals; Astrocytes; Autoradiography; Binding Sites; Binding, Competitive; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Etorphine; Pituitary Gland; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1985 |
A human neuroblastoma cell line expresses mu and delta opioid receptor sites.
Topics: Bone Neoplasms; Cell Line; Child, Preschool; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Female; Guanylyl Imidodiphosphate; Humans; Kinetics; Naloxone; Neuroblastoma; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sodium Chloride | 1986 |
Distinct subtypes of the opioid receptor with allosteric interactions in brain membranes.
Topics: Allosteric Site; Animals; Brain; Cations; Cell Membrane; Dihydromorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Guanylyl Imidodiphosphate; Kinetics; Magnesium; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Sodium | 1986 |
Sodium regulation of agonist binding at opioid receptors. I. Effects of sodium replacement on binding at mu- and delta-type receptors in 7315c and NG108-15 cells and cell membranes.
Topics: Adenylyl Cyclase Inhibitors; Animals; Cell Line; Cell Membrane; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Etorphine; Glioma; Guinea Pigs; Monensin; Naloxone; Neuroblastoma; Pituitary Neoplasms; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sodium | 1986 |
Sodium regulation of agonist binding at opioid receptors. II. Effects of sodium replacement on opioid binding in guinea pig cortical membranes.
Topics: Animals; Cell Membrane; Cerebral Cortex; Cyclazocine; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Etorphine; Guinea Pigs; Male; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium | 1986 |
Phosphatidylinositol turnover in neuroblastoma cells: regulation by bradykinin, acetylcholine, but not mu- and delta-opioid receptors.
Topics: Acetylcholine; Animals; Bradykinin; Cell Line; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Mice; Phosphatidylinositols; Rats; Receptors, Opioid | 1986 |
[Characterization of opioid receptors in the golden hamster brain].
Topics: Animals; Binding, Competitive; Brain; Brain Chemistry; Cricetinae; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Female; Male; Mesocricetus; Radioligand Assay; Receptors, Opioid | 1986 |
Differences of binding characteristics of non-selective opiates towards mu and delta receptor types.
Topics: Animals; Binding, Competitive; Brain; Cell Membrane; Cerebellum; Cyclazocine; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethylketocyclazocine; Etorphine; Male; Oligopeptides; Rabbits; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1987 |
Regional distribution of mu, delta and kappa opioid receptors in human brains from controls and parkinsonian subjects.
Topics: Aged; Aged, 80 and over; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Humans; Kinetics; Oligopeptides; Parkinson Disease; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1987 |
Stereospecificity of opiate-stimulated GTPase activity in brain.
Topics: Animals; Brain; Dextrorphan; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Etorphine; GTP Phosphohydrolases; In Vitro Techniques; Levorphanol; Narcotics; Phosphoric Monoester Hydrolases; Rats; Receptors, Opioid; Stereoisomerism | 1984 |
Multiple opiate binding sites in the central nervous system of the rabbit. Large predominance of a mu subtype in the cerebellum and characterization of a kappa subtype in the thalamus.
Topics: Animals; Binding, Competitive; Central Nervous System; Cerebellum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; In Vitro Techniques; Membranes; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thalamus | 1983 |
Different subtypes of opioid receptors have different affinities for G-proteins.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Amino Acid Sequence; Animals; Binding, Competitive; Cerebellum; Colforsin; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; GTP-Binding Proteins; Guinea Pigs; Humans; Hybrid Cells; Molecular Sequence Data; Morphine; Naloxone; Neoplasm Proteins; Nerve Tissue Proteins; Neuroblastoma; Oligopeptides; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured | 1994 |
Stereochemical requirements for pseudoirreversible inhibition of opioid mu receptor binding by the 3-methylfentanyl congeners, RTI-46144 and its enantiomers: evidence for different binding domains.
Topics: Animals; Binding Sites; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Fentanyl; Ligands; Molecular Conformation; Rats; Receptors, Opioid, mu; Stereoisomerism | 1993 |
Opioid antagonist-induced receptor upregulation: effects of concurrent agonist administration.
Topics: Animals; Brain; Drug Combinations; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Fentanyl; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Up-Regulation | 1994 |
Altered transition between agonist- and antagonist-favoring states of mu-opioid receptor in brain membranes with modified microviscosity.
Topics: Animals; Brain; Cholesterol Esters; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Male; Membrane Fluidity; Membranes; Naltrexone; Oleic Acid; Oleic Acids; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Sodium Chloride; Sufentanil; Viscosity | 1993 |
Solubilization of high-affinity, guanine nucleotide-sensitive mu-opioid receptors from 7315c cell membranes.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Cell Membrane; Cholic Acids; Detergents; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Guanine Nucleotides; Rats; Receptors, Opioid, mu; Solubility | 1993 |
Studies on mu and delta opioid receptor selectivity utilizing chimeric and site-mutagenized receptors.
Topics: Amino Acid Sequence; Analgesics; Base Sequence; Benzomorphans; Binding, Competitive; Cell Line; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Etorphine; GTP-Binding Proteins; Humans; Kidney; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Naloxone; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Protein Structure, Secondary; Receptors, Opioid, delta; Receptors, Opioid, mu; Recombinant Fusion Proteins; Substrate Specificity; Transfection | 1995 |
The stimulatory effect of opioids on mitogen-activated protein kinase in Chinese hamster ovary cells transfected to express mu-opioid receptors.
Topics: Animals; Benzeneacetamides; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Etorphine; Morphine; Narcotics; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Transfection; Virulence Factors, Bordetella | 1996 |
Lack of effect of gamma-hydroxybutyrate on mu, delta and kappa opioid receptor binding.
Topics: Adjuvants, Anesthesia; Analgesics; Animals; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Glioma; Guinea Pigs; Naloxone; Narcotic Antagonists; Narcotics; Neuroblastoma; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium Oxybate; Tritium; Tumor Cells, Cultured | 1996 |
The antiproliferative effect of opioid receptor agonists on the T47D human breast cancer cell line, is partially mediated through opioid receptors.
Topics: Adenocarcinoma; Amino Acid Sequence; Binding Sites; Breast Neoplasms; Cell Division; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Etorphine; Humans; Molecular Sequence Data; Morphine; Narcotic Antagonists; Opioid Peptides; Receptors, Opioid; Tumor Cells, Cultured | 1996 |
Differential opioid agonist regulation of the mouse mu opioid receptor.
Topics: Adenylate Cyclase Toxin; Analgesics; Animals; Buprenorphine; Colforsin; Cyclic AMP; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Levorphanol; Methadone; Mice; Morphine; Pertussis Toxin; Receptors, Opioid, mu; Virulence Factors, Bordetella | 1997 |
Efficacy and kinetics of opioid action on acutely dissociated neurons.
Topics: Animals; Brimonidine Tartrate; Calcium Channels; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Etorphine; Locus Coeruleus; Morphine; Narcotics; Potassium Channels; Quinoxalines | 1997 |
Agonist-induced signaling and trafficking of the mu-opioid receptor: role of serine and threonine residues in the third cytoplasmic loop and C-terminal domain.
Topics: Adenylyl Cyclases; Animals; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Activation; Etorphine; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Humans; Morphine; Mutagenesis, Site-Directed; Receptors, Opioid, mu; Serine; Signal Transduction; Threonine | 1997 |
Opioid peptide receptor studies. 7. The methylfentanyl congener RTI-4614-4 and its four enantiomers bind to different domains of the rat mu opioid receptor.
Topics: Affinity Labels; Analgesics; Analgesics, Opioid; Animals; Binding Sites; Binding, Competitive; COS Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Fentanyl; Melphalan; Membrane Proteins; Protein Structure, Tertiary; Radioligand Assay; Rats; Receptors, Opioid, mu; Recombinant Fusion Proteins; Stereoisomerism | 1998 |
Nonselective coupling of the human mu-opioid receptor to multiple inhibitory G-protein isoforms.
Topics: Binding Sites; Binding, Competitive; Buprenorphine; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Gene Expression; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Humans; Protein Binding; Protein Isoforms; Receptors, Opioid, mu; Recombinant Proteins; Saccharomyces cerevisiae; Spheroplasts; Transformation, Genetic | 1999 |
Dissociation of functional roles of dynamin in receptor-mediated endocytosis and mitogenic signal transduction.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Dynamins; Endocytosis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Activation; Etorphine; GTP Phosphohydrolases; GTP-Binding Proteins; Humans; Morphine; Phosphorylation; Receptors, Opioid; Signal Transduction; Transfection | 1999 |
Functional dissociation of mu opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction.
Topics: Arrestin; Cell Line; Drug Tolerance; Electrophysiology; Endocytosis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Flow Cytometry; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Guanine Nucleotides; Humans; Immunohistochemistry; Ligands; Morphine; Narcotics; Opioid-Related Disorders; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Muscarinic; Receptors, Opioid, mu; Signal Transduction | 1999 |
Differential binding properties of oripavines at cloned mu- and delta-opioid receptors.
Topics: Analgesics, Opioid; Animals; Benzamides; Binding, Competitive; Buprenorphine; Cloning, Molecular; Diprenorphine; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Fentanyl; Guanosine 5'-O-(3-Thiotriphosphate); Morphine; Naloxone; Piperazines; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Sulfur Radioisotopes; Thebaine; Tritium; Tumor Cells, Cultured | 1999 |
Opioid and cannabinoid receptors share a common pool of GTP-binding proteins in cotransfected cells, but not in cells which endogenously coexpress the receptors.
Topics: Analgesics; Analgesics, Opioid; Animals; COS Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Etorphine; Gene Expression; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Heterotrimeric GTP-Binding Proteins; Neuroblastoma; Phenanthridines; Radioligand Assay; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Signal Transduction; Sulfur Radioisotopes; Transfection; Tumor Cells, Cultured | 2000 |
Role of cAMP-dependent protein kinase (PKA) in opioid agonist-induced mu-opioid receptor downregulation and tolerance in mice.
Topics: Analgesics, Opioid; Animals; Brain; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Male; Mice; Morphine; Oligonucleotides, Antisense; Pain Measurement; Receptors, Opioid, mu | 2000 |
Opioid agonists differentially regulate mu-opioid receptors and trafficking proteins in vivo.
Topics: Analgesics, Opioid; Animals; beta-Adrenergic Receptor Kinases; Binding Sites; Cyclic AMP-Dependent Protein Kinases; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; G-Protein-Coupled Receptor Kinase 3; Male; Mice; Morphine; Receptors, Opioid, mu; RNA, Messenger | 2002 |
Potency differences for D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 as an antagonist of peptide and alkaloid micro-agonists in an antinociception assay.
Topics: Alkaloids; Analgesics, Opioid; Animals; Binding, Competitive; Buprenorphine; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Injections, Intraventricular; Injections, Subcutaneous; Male; Morphine; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pain Measurement; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, mu; Somatostatin | 2003 |
Activity of opioid ligands in cells expressing cloned mu opioid receptors.
Topics: Azocines; beta-Endorphin; Binding, Competitive; Butorphanol; Cell Line; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Fentanyl; Humans; Hydromorphone; Ligands; Morphine; Naltrexone; Phenazocine; Radioligand Assay; Receptors, Opioid, mu; Tritium | 2003 |
Opioids and the apoptotic pathway in human cancer cells.
Topics: Annexin A5; Apoptosis; Cell Adhesion; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Growth Substances; Humans; In Situ Nick-End Labeling; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Necrosis; Neoplasms; Tumor Cells, Cultured | 2003 |
Opioid agonist and antagonist treatment differentially regulates immunoreactive mu-opioid receptors and dynamin-2 in vivo.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Blotting, Western; Dynamin II; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Male; Mice; Morphine; Naloxone; Narcotic Antagonists; Radioligand Assay; Receptors, Opioid, mu; Spinal Cord | 2004 |
mu-Opioid receptor internalization-dependent and -independent mechanisms of the development of tolerance to mu-opioid receptor agonists: Comparison between etorphine and morphine.
Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Neuroglia; Neurons; Pain; Phosphorylation; Protein Transport; Receptors, Opioid, mu; Spinal Cord; Xanthines | 2006 |
Agonist-dependent postsynaptic effects of opioids on miniature excitatory postsynaptic currents in cultured hippocampal neurons.
Topics: Analgesics, Opioid; Animals; Cells, Cultured; Dendrites; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Excitatory Postsynaptic Potentials; Green Fluorescent Proteins; Hippocampus; Image Processing, Computer-Assisted; Mice; Morphine; Neostriatum; Neurons; Rats; Stimulation, Chemical; Transfection | 2007 |
Modulation of extracellular signal-regulated kinase (ERK) by opioid and cannabinoid receptors that are expressed in the same cell.
Topics: Analgesics; Analgesics, Opioid; Animals; Cell Line; Cell Line, Tumor; Central Nervous System; Cyclohexanols; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Activation; Etorphine; Extracellular Signal-Regulated MAP Kinases; Humans; MAP Kinase Kinase 1; Mice; Neuroblastoma; Neurons; Rats; Receptor, Cannabinoid, CB1; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Vascular Endothelial Growth Factor Receptor-1 | 2008 |
Agonist-specific down regulation of mu-opioid receptors: Different cellular pathways are activated by different opioid agonists.
Topics: Aminopeptidases; Analgesics, Opioid; Cell Adhesion; Clathrin; DNA, Complementary; Dose-Response Relationship, Drug; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Humans; Lysosomes; Membranes; Naloxone; Narcotic Antagonists; Phosphotransferases; Protease Inhibitors; Receptors, Opioid, mu; Serine Endopeptidases; Signal Transduction | 2008 |
Differential activation and trafficking of micro-opioid receptors in brain slices.
Topics: Analgesics, Opioid; Animals; Brain; Chelating Agents; Egtazic Acid; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Fluorescent Antibody Technique, Direct; Locus Coeruleus; Methadone; Mice; Mice, Knockout; Mice, Transgenic; Morphine; Neurons; Oxycodone; Oxymorphone; Protein Transport; Radioligand Assay; Receptors, Opioid, mu; Recombinant Fusion Proteins; Time Factors | 2008 |
Differential effects of opioid agonists on G protein expression in CHO cells expressing cloned human opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Benzamides; Blotting, Western; CHO Cells; Cricetinae; Cricetulus; Diterpenes, Clerodane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Female; Furans; Gene Expression; GTP-Binding Protein alpha Subunits, G12-G13; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Morphine; Oligopeptides; Piperazines; Pyrones; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2008 |
Modulating micro-opioid receptor phosphorylation switches agonist-dependent signaling as reflected in PKCepsilon activation and dendritic spine stability.
Topics: Analgesics, Opioid; Animals; Arrestins; beta-Arrestins; Cell Line; Dendritic Spines; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Fentanyl; Humans; Mice; Morphine; Phosphorylation; Protein Kinase C-epsilon; Receptors, Opioid, mu; Signal Transduction | 2011 |
Differences in the characteristics of tolerance to μ-opioid receptor agonists in the colon from wild type and β-arrestin2 knockout mice.
Topics: Analgesics, Opioid; Animals; Arrestins; beta-Arrestins; Colon; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Fentanyl; Ileum; Ligands; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle Contraction; Receptors, Opioid, mu | 2012 |
T394A Mutation at the μ Opioid Receptor Blocks Opioid Tolerance and Increases Vulnerability to Heroin Self-Administration in Mice.
Topics: Analgesia; Analgesics, Opioid; Animals; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Heroin Dependence; Male; Mice; Mice, Inbred C57BL; Morphine; Motor Activity; Mutation; Pain Measurement; Phosphorylation; Point Mutation; Receptors, Opioid, mu; Reward; Self Administration | 2016 |