etoposide has been researched along with wortmannin in 25 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (12.00) | 18.2507 |
| 2000's | 13 (52.00) | 29.6817 |
| 2010's | 9 (36.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Cooper, GM; Erhardt, P | 1 |
| Basu, S; Price, BD; Rosenzweig, KR; Youmell, M | 1 |
| Cao, CX; Kohn, KW; Pommier, Y; Shao, RG; Wold, MS; Zhang, H | 1 |
| Boulton, S; Durkacz, BW; Kyle, S | 1 |
| Cotter, TG; Knox, KA; McGahon, AJ; McKenna, SL; O'Gorman, DM | 1 |
| Bodero, A; Khanna, KK; Lavin, MF; Lees-Miller, SP; Ye, R; Zhou, BB | 1 |
| Ingram, AJ; Liu, L; Mak, TW; Okada, H; Ruland, J; Stambolic, V; Tang, D | 1 |
| Farber, JL; Karpinich, NO; Rothman, RJ; Russo, MA; Tafani, M | 1 |
| Ball, KL; Dornan, D; Kelleher, M; Pamment, J; Ramsay, E | 1 |
| Binet, JL; Delic, J; Deriano, L; Favaudon, V; Guipaud, O; Maciorowski, Z; Merle-Béral, H; Muller, C; Potocki-Veronese, G; Ricoul, M; Sabatier, L; Salles, B | 1 |
| Bettaieb, A; Favaudon, V; Fernet, M; Filomenko, R; Giocanti, N; Hennequin, C; Mégnin-Chanet, F; Reis, C; Solary, E | 1 |
| Ashworth, A; Caplin, M; Friedmann, BJ; Hartley, JA; Hochhauser, D; Lord, CJ; Savic, B; Shah, T | 1 |
| Chen, HL; Liu, SQ; Lv, P; Yu, HG; Yu, JP | 1 |
| Hemström, TH; Sandström, M; Zhivotovsky, B | 1 |
| Blasiak, J; Poplawski, T | 1 |
| Jingwei, J; Qiong, Z; Ruofan, H; Xiaohua, L; Xinli, Z; Zhaohui, C | 1 |
| Cho, SJ; Choi, JS; Kim, HY; Lee, SK; Lee, WH; Park, BD; Park, JH; Surh, YJ | 1 |
| Karmakar, P; Mukherjee, A; Samanta, S | 1 |
| Mackenzie, IC; Navsaria, H; Storey, A; Wray, H | 1 |
| Blasiak, J; Lewandowska, U; Pastwa, E; Poplawski, T; Somiari, RI; Somiari, SB | 1 |
25 other study(ies) available for etoposide and wortmannin
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection | 2009 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Activation of the CPP32 apoptotic protease by distinct signaling pathways with differential sensitivity to Bcl-xL.
Topics: Androstadienes; Apoptosis; bcl-X Protein; Caspase 1; Caspase 3; Caspases; Chromones; Cysteine Endopeptidases; DNA Damage; Enzyme Activation; Etoposide; Humans; Leukemia, Promyelocytic, Acute; Morpholines; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Recombinant Proteins; Signal Transduction; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Wortmannin | 1996 |
The DNA-dependent protein kinase participates in the activation of NF kappa B following DNA damage.
Topics: Androstadienes; DNA Damage; DNA-Activated Protein Kinase; DNA-Binding Proteins; Etoposide; Gamma Rays; Glioma; HeLa Cells; Humans; I-kappa B Proteins; NF-kappa B; NF-KappaB Inhibitor alpha; Nuclear Proteins; Phosphorylation; Protein Serine-Threonine Kinases; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Wortmannin | 1998 |
Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes.
Topics: Alkaloids; Androstadienes; Antigens, Nuclear; Ataxia Telangiectasia; Camptothecin; Cell Cycle; DNA Damage; DNA Helicases; DNA Repair; DNA Replication; DNA Topoisomerases, Type I; DNA-Activated Protein Kinase; DNA-Binding Proteins; Etoposide; Humans; Ku Autoantigen; Nuclear Proteins; Phosphorylation; Protein Serine-Threonine Kinases; Replication Protein A; Staurosporine; Tumor Cells, Cultured; Wortmannin | 1999 |
Mechanisms of enhancement of cytotoxicity in etoposide and ionising radiation-treated cells by the protein kinase inhibitor wortmannin.
Topics: Androstadienes; Animals; Antineoplastic Agents, Phytogenic; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; CHO Cells; Cricetinae; DNA Repair; DNA-Activated Protein Kinase; DNA-Binding Proteins; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Synergism; Enzyme Inhibitors; Etoposide; Female; Humans; Nuclear Proteins; Protein Serine-Threonine Kinases; Survival Analysis; Tumor Suppressor Proteins; Wortmannin | 2000 |
Sensitisation of HL60 human leukaemic cells to cytotoxic drug-induced apoptosis by inhibition of PI3-kinase survival signals.
Topics: Androstadienes; Antineoplastic Agents; Apigenin; Apoptosis; bcl-Associated Death Protein; bcl-X Protein; Camptothecin; Carrier Proteins; Cell Survival; Chromones; Cycloheximide; Dactinomycin; Dimerization; Doxorubicin; Drug Resistance, Neoplasm; Enzyme Inhibitors; Etoposide; Flavonoids; Genes, bcl-2; HL-60 Cells; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mitoxantrone; Morpholines; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Sirolimus; Wortmannin | 2000 |
The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent manner.
Topics: Androstadienes; Ataxia Telangiectasia Mutated Proteins; Benzoquinones; Caffeine; Cell Cycle Proteins; Cell Line; Checkpoint Kinase 2; DNA Fragmentation; DNA-Binding Proteins; Enzyme Inhibitors; Etoposide; Genistein; Humans; Lactams, Macrocyclic; Mutation; Phosphorylation; Plants, Medicinal; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Quinones; Rifabutin; Topoisomerase II Inhibitors; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Wortmannin | 2001 |
Akt is activated in response to an apoptotic signal.
Topics: 3T3 Cells; Androstadienes; Animals; Apoptosis; bcl-X Protein; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Etoposide; Immunoblotting; Mice; Nucleic Acid Synthesis Inhibitors; Phosphatidylinositol 3-Kinases; Poly(ADP-ribose) Polymerases; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Time Factors; Transfection; Wortmannin | 2001 |
The course of etoposide-induced apoptosis from damage to DNA and p53 activation to mitochondrial release of cytochrome c.
Topics: Androstadienes; Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Cell Line; Cell Survival; Cells, Cultured; Chloride Channels; Cycloheximide; Cytochrome c Group; Cytosol; Diuretics; DNA Damage; Enzyme Inhibitors; Etoposide; Fibroblasts; Furosemide; Mice; Mitochondria; Nucleic Acid Synthesis Inhibitors; Phosphorylation; Protein Synthesis Inhibitors; Protein Transport; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Time Factors; Transfection; Tumor Suppressor Protein p53; Ubiquinone; Up-Regulation; Wortmannin | 2002 |
Regulation of the IRF-1 tumour modifier during the response to genotoxic stress involves an ATM-dependent signalling pathway.
Topics: Androstadienes; Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cycloheximide; DNA; DNA Damage; DNA-Binding Proteins; Enzyme Inhibitors; Etoposide; Fibroblasts; Gamma Rays; Genes, p53; Genes, Reporter; Humans; Interferon Regulatory Factor-1; Melanoma; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Poly I-C; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Recombinant Fusion Proteins; RNA, Messenger; Signal Transduction; Transcription, Genetic; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Wortmannin | 2002 |
Human chronic lymphocytic leukemia B cells can escape DNA damage-induced apoptosis through the nonhomologous end-joining DNA repair pathway.
Topics: Androstadienes; Antibiotics, Antineoplastic; Antigens, Nuclear; Antineoplastic Agents, Phytogenic; Apoptosis; B-Lymphocytes; Blotting, Western; Cell Line, Transformed; Cell Line, Tumor; Cell-Free System; Chromones; Dimerization; DNA; DNA Damage; DNA Repair; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Etoposide; Gamma Rays; Humans; Ku Autoantigen; Leukemia, Lymphocytic, Chronic, B-Cell; Morpholines; Okadaic Acid; Phosphatidylinositol 3-Kinases; Protein Binding; Telomere; Time Factors; Wortmannin; Zinostatin | 2005 |
A role for PKCzeta in potentiation of the topoisomerase II activity and etoposide cytotoxicity by wortmannin.
Topics: Androstadienes; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Cell Line; Cell Line, Tumor; Cricetinae; Cricetulus; DNA Topoisomerases, Type II; Drug Synergism; Etoposide; HeLa Cells; Humans; Mice; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Rabbits; Topoisomerase II Inhibitors; Transfection; U937 Cells; Wortmannin | 2005 |
Interaction of the epidermal growth factor receptor and the DNA-dependent protein kinase pathway following gefitinib treatment.
Topics: Androstadienes; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Nucleus; Cisplatin; Cytosol; DNA; DNA-Activated Protein Kinase; ErbB Receptors; Etoposide; Gefitinib; Humans; Neoplasms; Protein Kinase Inhibitors; Quinazolines; Rats; RNA, Small Interfering; Wortmannin | 2006 |
Activation of Akt and ERK signalling pathways induced by etoposide confer chemoresistance in gastric cancer cells.
Topics: Androstadienes; Antineoplastic Agents, Phytogenic; Cell Division; Cell Line, Tumor; Drug Resistance, Neoplasm; Enzyme Activation; Etoposide; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Stomach Neoplasms; Tumor Suppressor Protein p53; Wortmannin | 2006 |
Inhibitors of the PI3-kinase/Akt pathway induce mitotic catastrophe in non-small cell lung cancer cells.
Topics: Androstadienes; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Survival; Chromones; Enzyme Inhibitors; Etoposide; Flavonoids; Flow Cytometry; Humans; Indoles; Lung Neoplasms; MAP Kinase Kinase Kinases; Mitosis; Morpholines; Nocodazole; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Staurosporine; Wortmannin | 2006 |
BCR/ABL downregulates DNA-PK(CS)-dependent and upregulates backup non-homologous end joining in leukemic cells.
Topics: Androstadienes; Cell Line, Tumor; Cell Survival; Comet Assay; DNA Breaks, Double-Stranded; DNA Repair; DNA-Activated Protein Kinase; Down-Regulation; Etoposide; Fusion Proteins, bcr-abl; Humans; Leukemia; Nuclear Proteins; Piperazines; Recombination, Genetic; Time Factors; Up-Regulation; Wortmannin | 2010 |
Role of dephosphorylation of FOXO1 on apoptosis induced by wortmannin for non-Hodgkin's lymphoma cells.
Topics: Androstadienes; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Etoposide; Forkhead Box Protein O1; Forkhead Transcription Factors; Humans; Lymphoma, Non-Hodgkin; Membrane Proteins; Phosphorylation; Proto-Oncogene Proteins; Time Factors; Up-Regulation; Wortmannin | 2010 |
Potentiation of etoposide-induced apoptosis in HeLa cells by co-treatment with KG-135, a quality-controlled standardized ginsenoside formulation.
Topics: Androstadienes; Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Synergism; Etoposide; Female; Ginsenosides; HeLa Cells; Humans; Korea; Liver Neoplasms; Medicine, East Asian Traditional; Membrane Potentials; Mitochondria; Mycotoxins; Phosphoserine; Stomach Neoplasms; Wortmannin | 2010 |
Inactivation of PTEN is responsible for the survival of Hep G2 cells in response to etoposide-induced damage.
Topics: Androstadienes; Antineoplastic Agents; Cell Cycle; Cell Line; Cell Survival; Drug Resistance, Neoplasm; Etoposide; Hep G2 Cells; Histones; Humans; Liver; Oncogene Protein v-akt; Phosphorylation; PTEN Phosphohydrolase; Signal Transduction; Wortmannin | 2011 |
α6 Integrin and CD44 enrich for a primary keratinocyte population that displays resistance to UV-induced apoptosis.
Topics: Androstadienes; Antineoplastic Agents; Apoptosis; Benzamides; Camptothecin; Cell Proliferation; Cells, Cultured; Cisplatin; Drug Resistance; Etoposide; Fluorescent Antibody Technique; Gene Expression; Humans; Hyaluronan Receptors; Imatinib Mesylate; Integrin alpha6; Keratinocytes; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Piperazines; Primary Cell Culture; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factors; Tumor Suppressor Proteins; Ultraviolet Rays; Wortmannin | 2012 |
Wortmannin potentiates the combined effect of etoposide and cisplatin in human glioma cells.
Topics: Androstadienes; Cell Line, Tumor; Cisplatin; DNA Breaks, Double-Stranded; DNA Damage; DNA End-Joining Repair; DNA-Activated Protein Kinase; Drug Synergism; Etoposide; Glioma; Humans; Wortmannin | 2014 |