etoposide has been researched along with verapamil in 110 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 13 (11.82) | 18.7374 |
1990's | 51 (46.36) | 18.2507 |
2000's | 23 (20.91) | 29.6817 |
2010's | 22 (20.00) | 24.3611 |
2020's | 1 (0.91) | 2.80 |
Authors | Studies |
---|---|
Aubé, J; Borchardt, RT; Gao, J; Murase, O; Schowen, RL | 1 |
Belinsky, MG; Chen, ZS; Kruh, GD; Rea, PA; Zeng, H | 1 |
Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA | 1 |
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
Borchardt, RT; Horie, K; Tang, F | 2 |
Belinsky, MG; Chen, ZS; Hopper-Borge, E; Kotova, E; Kruh, GD; Shchaveleva, I | 1 |
Fischer, H; Huwyler, J; Poli, S; Schwab, D; Tabatabaei, A | 1 |
Thakker, DR; Troutman, MD | 1 |
Bacsó, Z; Cianfriglia, M; Fenyvesi, F; Goda, K; Kappelmayer, J; Lustyik, G; Nagy, H; Szabó, G; Szilasi, M | 1 |
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
Cai, W; Hao, Y; Hu, P; Ma, D; Pan, H; Xie, X; Yu, AD; Yu, J; Yuan, J; Zhang, L; Zhu, H | 1 |
Lombardo, F; Obach, RS; Waters, NJ | 1 |
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
Campillo, NE; Guerra, A; Páez, JA | 1 |
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L | 1 |
Avdeef, A; Tam, KY | 1 |
Cheung, CC; Fung, KP; Lai, PB; Lee, WY; Liu, KW; Wong, J; Yeung, JH | 1 |
Ghosh, I; Manoharlal, R; Prakash, O; Prasad, R; Puri, N; Sharma, M | 1 |
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
Chen, X; Lin, X; Skolnik, S; Wang, J | 1 |
Arefolov, A; Clardy, J; Clarke, AS; Ishihara, K; Marks, KM; Park, ES; Pelish, HE; Ring, JE; Russo, K | 1 |
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
Esaki, T; Kawashima, H; Komura, H; Kuroda, M; Mizuguchi, K; Natsume-Kitatani, Y; Ohashi, R; Watanabe, R | 1 |
Lafleur, MV; Lankelma, J; Mans, DR; Pinedo, HM; Retèl, J; Schuurhuis, GJ; Treskes, M | 1 |
Carmichael, J; Harris, AL; Houlbrook, S; Kirk, J; Lien, EA; Philip, P; Stuart, NS; Tonkin, K | 1 |
Cowan, KH; Dixon, KH; Horton, J; Kelley, K; Morrow, C; Nakagawa, M; Schneider, E | 1 |
Demant, EJ; Friche, E; Jensen, PB; Sehested, M | 1 |
Dalton, WS; Grogan, TM; Lehnert, M; Miller, TP; Plezia, P; Roe, DJ; Salmon, SE | 1 |
Feng, MR; Grossman, HB; Liebert, M; Mancini, WR; Wagner, JG; Wedemeyer, G; Williams, M | 1 |
Flanigan, P; Freshney, RI; Hamilton, TG; Kaye, SB; Merry, S | 1 |
de Jong, S; de Vries, EG; Mulder, NH; Zijlstra, JG | 1 |
Arnold, ST; Felsted, RL; Politi, PM; Sinha, BK | 1 |
Ideguchi, H; Kato, S; Muta, K; Nawata, H; Nishimura, J | 1 |
Koch, G; Reeve, JG; Twentyman, PR; Wright, KA | 1 |
Larsson, R; Nygren, P | 2 |
Andreeff, M; Howell, SB; Shalinsky, DR | 1 |
Daniel, JC; Levy, SB; Slapak, CA | 1 |
Arnold, A; Figueredo, A; Findlay, B; Goodyear, M; Jones, A; Neville, A; Normandeau, R | 1 |
Aihara, M; Blume, KG; Chao, NJ; Sikic, BI | 2 |
Bennetts, G; Cairo, MS; Sender, L; Toy, C; van de Ven, C | 1 |
Anas, N; Cairo, MS; Sender, L; Siegel, S | 1 |
Ardiet, C; Navarro, C; Sapet, C; Tranchand, B | 1 |
Cheng, YC; Ferguson, PJ; Fisher, MH; Li, DH; Stephenson, J; Zhou, BS | 1 |
Kawatsu, H; Kojima, K; Nishiyama, Y; Shimokata, K; Takagi, E; Yoshida, S | 1 |
Bénard, J; Da Silva, J; Riou, G; Teyssier, JR | 1 |
Ahmedzai, S; Banham, S; Burnett, A; Cunningham, D; Dorward, A; Hutcheon, A; Kaye, S; Lucie, N; Soukop, M | 1 |
Kaye, SB; Merry, S; Smith, JG; Smith, MA | 1 |
Murray, SL; Slater, LM; Stupecky, M; Sweet, P; Wetzel, MW | 1 |
Cheng, YC; Ferguson, PJ | 1 |
Gross, M; Ross, WE; Yalowich, JC; Zucali, JR | 1 |
Ross, WE; Yalowich, JC | 2 |
Lim, CK; Peters, TJ | 1 |
Balis, FM; Bates, SE; Bryant, G; Chabner, BA; Jamis-Dow, C; Klecker, RW; Kohler, DR; Steinberg, SM; Wilson, WH; Wittes, RE | 1 |
Bates, SE; Bryant, G; Fojo, A; Herdt, J; Jaffe, ES; Regis, J; Steinberg, SM; Wilson, WH; Wittes, RE; Zhan, Z | 1 |
Osann, K; Slater, L; Stupecky, M; Sweet, P; Wetzel, M | 1 |
Davey, MW; Davey, RA; Hargrave, RM; Kidman, AD | 1 |
Adler, KM; Brophy, NA; Fisher, GA; Halsey, J; Lum, BL; Sikic, BI; Yahanda, AM | 1 |
Cowie, FJ; Dick, G; Flanagan, RJ; Judson, I; McCarthy, PT; Phillips, M; Pinkerton, CR | 1 |
Yung, BY | 1 |
Arriagada, R; Arvelo, F; Bourgeois, Y; Goguel, AF; Le Chevalier, T; Lizard, G; Poupon, MF | 1 |
Danks, MK; Davies, SL; Hickson, ID; Hill, BT; Hosking, LK; Shellard, SA; Whelan, RD | 1 |
Chang, JH; Grossman, HB; Liebert, M; Shinohara, N; Wedemeyer, G | 1 |
Milroy, R | 1 |
Dong, J; Johdo, O; Naito, M; Seimiya, H; Tatsuta, T; Tsuruo, T | 1 |
Arvelo, F; Bastian, G; Bichat, F; Bourgeois, Y; Grossin, F; Jacrot, M; Le Chevalier, T; Poupon, MF | 1 |
Hasegawa, S; Koga, H; Kotoh, S; Kumazawa, J; Kuwano, M; Naito, S; Yokomizo, A | 1 |
Balkenende, AY; Slaper-Cortenbach, IC; van den Berg, H; van der Schoot, CE; Van Leeuwen, EF; Vervoordeldonk, SF; von dem Borne, AE | 1 |
Gatzemeier, U; Schneider, A; von Pawel, J | 1 |
Ogretmen, B; Safa, AR | 1 |
Alvarez, M; Bates, SE; Chabner, B; Fojo, AT; Hose, C; Kang, YK; Monks, A; Regis, J; Robey, R; Wilson, WH; Zhan, Z | 1 |
Aran, JM; Gottesman, MM; Licht, T; Pastan, I | 1 |
Cowan, KH; Fukuda, M; Ikeda, K; Kohno, S; Matsuo, I; Nakano, R; Narasaki, F; Oka, M; Soda, H; Takatani, H; Terashi, K; Tomonaga, M | 1 |
Ford, PJ; Germann, UA; Harding, MW; Mason, VS; Shlyakhter, D | 1 |
Alken, P; Köhrmann, KU; Kreukler, C; Nebe, T; Siegsmund, MJ; Steidler, A | 1 |
Cianfriglia, M; Frey, BM; Gieseler, F; Lehnert, M; Scheper, RJ; Schmid, L; Schneider, E; Shao, Y; Twentyman, PR; Wyler, B | 1 |
de Tinguy-Moreaud, E; Denois, F; Lagarde, P; Montaudon, D; Pourquier, P; Robert, J | 1 |
Bates, SE; Dickstein, B; Fojo, AT; Gamelin, E; Regis, J; Sandor, VA; Wilson, W; Zhan, Z | 1 |
Allan, WP; Creighton, AM; Fattman, CL; Hasinoff, BB; Kuschak, TI; Thampatty, P; Yalowich, JC | 1 |
Benderra, Z; Manfait, M; Morjani, H; Trussardi, A | 1 |
Cowie, FJ; Pinkerton, CR; Pritchard-Jones, K; Renshaw, J | 1 |
Guo, A; Hu, P; Makhey, VD; Norris, DA; Sinko, PJ; Yan, J | 1 |
Anyanwutaku, I; Chang, YH; Cheng, YC; Gaj, CL | 1 |
Horton, JK; Reuss, L; Vanoye, CG | 1 |
Cretney, E; Johnstone, RW; Smyth, MJ | 1 |
Cory, AH; Cory, JG | 1 |
Eriksen, J; Litman, T; Maare, C; Nielsen, D; Skovsgaard, T | 1 |
Edington, KG; Fairbairn, LJ; Gagen, D; Heyworth, CM | 1 |
Bailly, C; Cuevas, C; Kluza, J; Lansiaux, A; Otero, G; Tardy, C; Vanhuyse, M | 1 |
Balimane, P; Kadiyala, P; Olah, T; Smalley, J; Xin, B | 1 |
Ades, S; Gould, CJ; Jones, GK; Levy, SB; Maxfield, LF | 1 |
Jankovic, D; Kanazir, S; Markovic, ID; Markovic, JZ; Pesic, M; Rakic, L; Ruzdijic, S | 1 |
Cole, B; Epel, D; Hamdoun, A; Thurber, RV | 1 |
Bhatia, PA; Moaddel, R; Wainer, IW | 1 |
Ai, H; Gu, Y; Hao, G; Li, Y; Peng, Y; Sun, J; Wang, G; Wu, X; Zhang, J; Zhang, X; Zheng, Y; Zhou, F | 1 |
Mo, R; Ping, Q; Sun, M; Xiao, Y; Zhang, C | 1 |
Huang, J; Li, G; Si, L; Xue, K; Zhao, G | 1 |
Habicht, KL; Khadeer, MA; Moaddel, R; Shimmo, R; Singh, NS; Wainer, IW | 1 |
Fu, L; Hu, D; Li, Y; Su, L; Yang, F; Zhang, M | 1 |
Coyle, B; Grundy, RG; Jackson, HK; Kerr, ID; Kilday, JP; Liu, JF; Sabnis, DH; Storer, LCD | 1 |
4 review(s) available for etoposide and verapamil
Article | Year |
---|---|
Membrane transporters in drug development.
Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs | 2010 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Clinical reversal of multidrug resistance.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Clinical Trials as Topic; Cyclosporine; Drug Resistance, Multiple; Etoposide; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Proteins; Neoplasms; Paclitaxel; Pharmaceutical Preparations; Verapamil | 1994 |
Clinical reversal of multidrug resistance.
Topics: Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclophosphamide; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Etoposide; Humans; Lymphoma, Non-Hodgkin; Prednisone; Verapamil; Vincristine | 1996 |
9 trial(s) available for etoposide and verapamil
Article | Year |
---|---|
High-dose tamoxifen as an enhancer of etoposide cytotoxicity. Clinical effects and in vitro assessment in p-glycoprotein expressing cell lines.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Dose-Response Relationship, Drug; Drug Resistance; Drug Screening Assays, Antitumor; Drug Synergism; Etoposide; Female; Humans; Male; Membrane Glycoproteins; Middle Aged; Neoplasms; Tamoxifen; Tumor Cells, Cultured; Verapamil | 1992 |
Multidrug-resistant myeloma: laboratory and clinical effects of verapamil as a chemosensitizer.
Topics: Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Etoposide; Humans; Immunohistochemistry; Membrane Glycoproteins; Multiple Myeloma; Verapamil | 1991 |
Clinical trial of continuous infusion verapamil, bolus vinblastine, and continuous infusion VP-16 in drug-resistant pediatric tumors.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Child; Child, Preschool; Clinical Trials as Topic; Etoposide; Humans; Infusions, Intravenous; Leukemia; Liver Neoplasms; Neuroblastoma; Verapamil; Vinblastine | 1989 |
Phase I and pharmacokinetic study of the multidrug resistance modulator dexverapamil with EPOCH chemotherapy.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cross-Over Studies; Cyclophosphamide; Doxorubicin; Drug Resistance, Multiple; Etoposide; Female; Humans; Hypotension; Leukocyte Count; Lymphoma; Male; Middle Aged; Neutrophils; Platelet Count; Prednisone; Sarcoma; Stereoisomerism; Verapamil; Vincristine | 1995 |
Controlled trial of dexverapamil, a modulator of multidrug resistance, in lymphomas refractory to EPOCH chemotherapy.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cross-Over Studies; Cyclophosphamide; Doxorubicin; Drug Resistance, Multiple; Etoposide; Female; Hodgkin Disease; Humans; Lymphoma; Lymphoma, Non-Hodgkin; Male; Middle Aged; Polymerase Chain Reaction; Prednisone; Remission Induction; Stereoisomerism; Verapamil; Vincristine | 1995 |
Clinical reversal of multidrug resistance.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Clinical Trials as Topic; Cyclosporine; Drug Resistance, Multiple; Etoposide; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Proteins; Neoplasms; Paclitaxel; Pharmaceutical Preparations; Verapamil | 1994 |
Continuous-infusion verapamil with etoposide in relapsed or resistant paediatric cancers.
Topics: Adolescent; Adult; Bone Neoplasms; Child; Child, Preschool; Drug Administration Schedule; Drug Resistance, Multiple; Etoposide; Female; Hodgkin Disease; Humans; Infant; Infusions, Intravenous; Kidney Neoplasms; Male; Neoplasms; Neuroblastoma; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Rhabdomyosarcoma; Sarcoma, Ewing; Verapamil; Wilms Tumor | 1995 |
A randomised clinical study of verapamil in addition to combination chemotherapy in small cell lung cancer. West of Scotland Lung Cancer Research Group, and the Aberdeen Oncology Group.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Blood Pressure; Carcinoma, Small Cell; Doxorubicin; Drug Administration Schedule; Drug Resistance; Etoposide; Female; Humans; Lung Neoplasms; Male; Middle Aged; Survival Analysis; Verapamil; Vincristine | 1993 |
Randomised trial of vindesine and etoposide +/- dexverapamil in advanced non-small cell lung cancer: first results.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Calcium Channel Blockers; Carcinoma, Non-Small-Cell Lung; Etoposide; Female; Humans; Lung Neoplasms; Male; Middle Aged; Verapamil; Vindesine | 1995 |
98 other study(ies) available for etoposide and verapamil
Article | Year |
---|---|
A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells.
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Biological Transport, Active; Caco-2 Cells; Drug Interactions; Humans; Ligands; Models, Theoretical; Paclitaxel; Tritium | 2001 |
Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport.
Topics: 3T3 Cells; Animals; ATP-Binding Cassette Transporters; Biological Transport; Drug Resistance, Multiple; Folic Acid; Humans; Leucovorin; Methotrexate; Mice; Multidrug Resistance-Associated Proteins; Osmolar Concentration; Polyglutamic Acid; Tritium | 2001 |
Rational use of in vitro P-glycoprotein assays in drug discovery.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera | 2001 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa?
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Cell Line; Digoxin; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Genes, MDR; Humans; Intestinal Mucosa; Transfection | 2002 |
Are MDCK cells transfected with the human MRP2 gene a good model of the human intestinal mucosa?
Topics: Animals; Caco-2 Cells; Cell Line; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Intestinal Mucosa; Mitochondrial Proteins; Multidrug Resistance-Associated Protein 2; Ribosomal Proteins; Saccharomyces cerevisiae Proteins; Transfection; Vinblastine | 2002 |
Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10).
Topics: Biological Transport; Cells, Cultured; Cyclosporine; Estradiol; Glycocholic Acid; Humans; Kinetics; Leukotriene Antagonists; Leukotriene C4; Multidrug Resistance-Associated Proteins; Osmotic Pressure; Propionates; Quinolines; Recombinant Proteins; Transfection | 2003 |
Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cells, Cultured; Drug Evaluation, Preclinical; Fluoresceins; Fluorescent Dyes; Humans; Indicators and Reagents; Mice; Models, Molecular; Rhodamines; Species Specificity; Swine | 2003 |
Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blotting, Western; Cells, Cultured; Diffusion; Humans; Intestinal Absorption; Intestinal Mucosa; Models, Biological; Permeability; Pharmaceutical Preparations; Pharmacokinetics | 2003 |
Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies.
Topics: Adenosine Triphosphatases; Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Calcium Channel Blockers; Cyclosporine; Detergents; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluoresceins; Humans; Ivermectin; Mice; NIH 3T3 Cells; Substrate Specificity | 2004 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Small molecule regulators of autophagy identified by an image-based high-throughput screen.
Topics: Autophagy; Calcium Channel Blockers; Cell Line, Tumor; Drug Evaluation, Preclinical; Fluspirilene; Glioblastoma; Green Fluorescent Proteins; Humans; Intracellular Membranes; Loperamide; Microtubule-Associated Proteins; Mycotoxins; Peptides; Phagosomes; Phosphatidylinositol Phosphates; Pimozide; Protein Kinases; Recombinant Fusion Proteins; Sirolimus; Small Molecule Libraries; TOR Serine-Threonine Kinases; Trifluoperazine; Zinc Fingers | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis | 2010 |
Cytotoxic effects of tanshinones from Salvia miltiorrhiza on doxorubicin-resistant human liver cancer cells.
Topics: Abietanes; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Hepatocellular; Doxorubicin; Drug Resistance, Neoplasm; Humans; Models, Biological; Molecular Structure; Phenanthrenes; Plants, Medicinal; Salvia miltiorrhiza | 2010 |
Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans.
Topics: Candida albicans; Membrane Transport Proteins; Saccharomyces cerevisiae; Structure-Activity Relationship; Substrate Specificity | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model.
Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity | 2011 |
The selectivity of austocystin D arises from cell-line-specific drug activation by cytochrome P450 enzymes.
Topics: Aflatoxin B1; Aflatoxins; Antineoplastic Agents; Aspergillus; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cytochrome P-450 Enzyme System; DNA Damage; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Humans; Molecular Structure | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Development of an
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Cell Line; Computer Simulation; Endothelial Cells; Gene Knockout Techniques; Humans; Organic Chemicals; Rats, Transgenic | 2021 |
Modulation by D,L-buthionine-S,R-sulphoximine of etoposide cytotoxicity on human non-small cell lung, ovarian and breast carcinoma cell lines.
Topics: Antimetabolites, Antineoplastic; Breast Neoplasms; Buthionine Sulfoximine; Carcinoma, Non-Small-Cell Lung; Cisplatin; Doxorubicin; Drug Synergism; Etoposide; Female; Glutathione; Humans; Lung Neoplasms; Methionine Sulfoximine; Ovarian Neoplasms; Tumor Cells, Cultured; Verapamil | 1992 |
Reduced intracellular drug accumulation in the absence of P-glycoprotein (mdr1) overexpression in mitoxantrone-resistant human MCF-7 breast cancer cells.
Topics: Adenosine Triphosphate; Antibodies; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Breast Neoplasms; Cell Membrane Permeability; Cross Reactions; DNA Topoisomerases, Type II; Doxorubicin; Drug Resistance; Etoposide; Gene Expression; Humans; Intracellular Fluid; Membrane Glycoproteins; Membrane Proteins; Mitoxantrone; Tumor Cells, Cultured; Verapamil | 1992 |
Relationship of VP-16 to the classical multidrug resistance phenotype.
Topics: Affinity Labels; Animals; Carbon Radioisotopes; Carcinoma, Ehrlich Tumor; Cell Membrane; Cell Nucleus; Daunorubicin; Drug Resistance; Etoposide; Phenotype; Polysorbates; Tumor Cells, Cultured; Verapamil | 1992 |
Effect of verapamil on the uptake and efflux of etoposide (VP16) in both sensitive and resistant cancer cells.
Topics: Animals; Carcinoma, Transitional Cell; Culture Media; Drug Resistance; Etoposide; Glucose; Humans; Kinetics; Leukemia L1210; Mice; Tumor Cells, Cultured; Urinary Bladder Neoplasms; Verapamil | 1991 |
Circumvention of pleiotropic drug resistance in subcutaneous tumours in vivo with verapamil and clomipramine.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Clomipramine; Dactinomycin; Doxorubicin; Drug Resistance; Etoposide; Female; Male; Mice; Mice, Inbred AKR; Osteosarcoma; Verapamil; Vincristine | 1991 |
Reduced DNA topoisomerase II activity and drug-induced DNA cleavage activity in an adriamycin-resistant human small cell lung carcinoma cell line.
Topics: Amsacrine; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Small Cell; Cell Cycle; Cell Division; DNA; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Doxorubicin; Drug Resistance; Etoposide; Humans; Lung Neoplasms; Membrane Glycoproteins; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Verapamil | 1990 |
P-glycoprotein-independent mechanism of resistance to VP-16 in multidrug-resistant tumor cell lines: pharmacokinetic and photoaffinity labeling studies.
Topics: Affinity Labels; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding, Competitive; Breast Neoplasms; Cricetinae; Cricetulus; Dactinomycin; Doxorubicin; Drug Resistance; Etoposide; Humans; Membrane Glycoproteins; Neoplasm Proteins; Tumor Cells, Cultured; Verapamil; Vinblastine; Vindesine | 1990 |
Mechanisms involved in the development of adriamycin resistance in human leukemic cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Cell Division; Cell Line; DNA Topoisomerases, Type I; Doxorubicin; Drug Resistance; Etoposide; Glutathione Transferase; Humans; In Vitro Techniques; Leukemia, Myeloid; Membrane Glycoproteins; Verapamil; Vincristine | 1990 |
Chemosensitisation by verapamil and cyclosporin A in mouse tumour cells expressing different levels of P-glycoprotein and CP22 (sorcin).
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Calcium-Binding Proteins; Carcinosarcoma; Cell Line; Colchicine; Cyclosporins; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Etoposide; Gene Expression; Mammary Neoplasms, Animal; Membrane Glycoproteins; Mice; Neoplasm Proteins; Verapamil; Vincristine | 1990 |
Verapamil and cyclosporin A potentiate the effects of chemotherapeutic drugs in the human medullary thyroid carcinoma TT cell line not expressing the 170 kDa P-glycoprotein.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporins; Daunorubicin; Dose-Response Relationship, Drug; Drug Resistance; Drug Synergism; Etoposide; Humans; Membrane Glycoproteins; Thyroid Neoplasms; Tumor Cells, Cultured; Verapamil; Vincristine | 1990 |
Modulation of drug sensitivity by dipyridamole in multidrug resistant tumor cells in vitro.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Squamous Cell; Cell Survival; Colchicine; Dipyridamole; Drug Resistance; Drug Synergism; Etoposide; Humans; In Vitro Techniques; Membrane Glycoproteins; Neoplasm Proteins; Verapamil; Vinblastine | 1990 |
Sequential emergence of distinct resistance phenotypes in murine erythroleukemia cells under adriamycin selection: decreased anthracycline uptake precedes increased P-glycoprotein expression.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Line; Cell Survival; Daunorubicin; Doxorubicin; Drug Resistance; Etoposide; Kinetics; Leukemia, Experimental; Membrane Glycoproteins; Mice; Mutation; Neoplasm Proteins; Phenotype; Verapamil; Vincristine | 1990 |
Differential in vitro sensitivity of human tumor and normal cells to chemotherapeutic agents and resistance modulators.
Topics: Adenocarcinoma; Antineoplastic Agents; Buthionine Sulfoximine; Cell Division; Cell Line; Cell Survival; Cisplatin; Cyclosporins; Doxorubicin; Drug Screening Assays, Antitumor; Etoposide; Humans; Kidney Neoplasms; Kinetics; Leukemia; Lymphocytes; Methionine Sulfoximine; Neurilemmoma; Tumor Cells, Cultured; Verapamil; Vincristine | 1991 |
Addition of verapamil and tamoxifen to the initial chemotherapy of small cell lung cancer. A phase I/II study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Doxorubicin; Drug Administration Schedule; Drug Evaluation; Drug Resistance; Etoposide; Female; Humans; Lung Neoplasms; Male; Middle Aged; Tamoxifen; Time Factors; Verapamil; Vincristine | 1990 |
Modulation of etoposide (VP-16) cytotoxicity by verapamil or cyclosporine in multidrug-resistant human leukemic cell lines and normal bone marrow.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Cell Division; Cell Survival; Cyclosporins; Drug Resistance; Etoposide; Hematopoietic Stem Cells; Humans; Leukemia; Tumor Cells, Cultured; Verapamil | 1990 |
Combination chemotherapy and verapamil to purge drug resistant leukemia cells from human bone marrow.
Topics: Bone Marrow; Bone Marrow Transplantation; Cell Division; Cells, Cultured; Colony-Forming Units Assay; Drug Interactions; Drug Resistance; Etoposide; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured; Verapamil | 1990 |
Assessment of purging with multidrug resistance (MDR) modulators and VP-16: results of long-term marrow culture.
Topics: Bone Marrow Cells; Cell Count; Cell Survival; Cells, Cultured; Cyclosporins; Drug Resistance; Etoposide; Granulocytes; Hematopoietic Stem Cells; Humans; Macrophages; Methylcellulose; Verapamil | 1990 |
[Cellular pharmacokinetics of melphalan alone or in combination on human lymphoma or lymphoblasts].
Topics: Antimetabolites; Blastomeres; Burkitt Lymphoma; Buthionine Sulfoximine; Cell Line; Etoposide; Humans; Lymphocytes; Melphalan; Methionine Sulfoximine; Verapamil | 1989 |
Combined modalities of resistance in etoposide-resistant human KB cell lines.
Topics: DNA Damage; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Doxorubicin; Drug Resistance; Etoposide; Humans; KB Cells; Verapamil; Vincristine | 1988 |
Establishment and characterization of resistant cells to etoposide (VP16) from a mouse breast cancer cell line, FM3A.
Topics: Animals; Cell Survival; DNA Topoisomerases, Type II; Drug Resistance; Etoposide; Mammary Neoplasms, Experimental; Mice; Tumor Cells, Cultured; Verapamil | 1988 |
Over-expression of MDR1 gene with no DNA amplification in a multiple-drug-resistant human ovarian carcinoma cell line.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Chromosome Deletion; Dactinomycin; Doxorubicin; Drug Resistance; Etoposide; Female; Humans; Mice; Mice, Nude; Ovarian Neoplasms; Phenotype; Tumor Cells, Cultured; Verapamil; Vincristine | 1989 |
The role of VP-16 in the treatment of small-cell lung cancer: studies of the West of Scotland Lung Cancer Group.
Topics: Carcinoma, Small Cell; Cyclophosphamide; Drug Resistance; Drug Therapy, Combination; Etoposide; Female; Humans; Lung Neoplasms; Male; Middle Aged; Podophyllotoxin; Verapamil | 1985 |
Clinically relevant concentrations of verapamil do not enhance the sensitivity of human bone marrow CFU-GM to adriamycin and VP16.
Topics: Bone Marrow; Bone Marrow Cells; Colony-Forming Units Assay; Doxorubicin; Drug Synergism; Etoposide; Hematopoietic Stem Cells; Humans; Verapamil | 1988 |
Verapamil potentiation of VP-16-213 in acute lymphatic leukemia and reversal of pleiotropic drug resistance.
Topics: Animals; Antineoplastic Agents; Cell Survival; Cells, Cultured; Daunorubicin; Dose-Response Relationship, Drug; Drug Resistance; Drug Synergism; Etoposide; Humans; Leukemia L1210; Leukemia P388; Leukemia, Experimental; Leukemia, Lymphoid; Mice; Podophyllotoxin; Verapamil; Vincristine | 1986 |
Transient protection of cultured human cells against antitumor agents by 12-O-tetradecanoylphorbol-13-acetate.
Topics: Antineoplastic Agents; Cell Division; Cell Survival; Cells, Cultured; Diglycerides; Dose-Response Relationship, Drug; Etoposide; Humans; Methotrexate; Mitoxantrone; Nasopharyngeal Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Type C Phospholipases; Verapamil; Vincristine | 1987 |
Effects of verapamil on etoposide, vincristine, and adriamycin activity in normal human bone marrow granulocyte-macrophage progenitors and in human K562 leukemia cells in vitro.
Topics: Bone Marrow; Cell Survival; Cells, Cultured; Doxorubicin; Drug Synergism; Etoposide; Granulocytes; Hematopoietic Stem Cells; Humans; Leukemia, Myeloid; Macrophages; Podophyllotoxin; Verapamil; Vincristine | 1985 |
Verapamil-induced augmentation of etoposide accumulation in L1210 cells in vitro.
Topics: Animals; Cells, Cultured; DNA Repair; Drug Synergism; Etoposide; Leukemia L1210; Mice; Podophyllotoxin; Tritium; Verapamil | 1985 |
Ammonium acetate: a general purpose buffer for clinical applications of high-performance liquid chromatography.
Topics: Acetates; Bilirubin; Biogenic Amines; Buffers; Catecholamines; Chromatography, High Pressure Liquid; Creatinine; Etoposide; Porphyrins; Retinoids; Teniposide; Verapamil | 1984 |
Potentiation of etoposide-induced DNA damage by calcium antagonists in L1210 cells in vitro.
Topics: Animals; Cell Division; Cell Nucleus; Cell Survival; DNA Replication; DNA, Neoplasm; Drug Synergism; Etoposide; Gallopamil; Kinetics; Leukemia L1210; Mice; Podophyllotoxin; Verapamil | 1984 |
Comparison of cyclosporin A, verapamil, PSC-833 and cremophor EL as enhancing agents of VP-16 in murine lymphoid leukemias.
Topics: Animals; Cell Survival; Cyclosporine; Cyclosporins; Drug Synergism; Etoposide; Glycerol; Leukemia L1210; Leukemia P388; Mice; Survival Analysis; Tumor Cells, Cultured; Verapamil | 1995 |
Development of drug resistance is reduced with idarubicin relative to other anthracyclines.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Cell Survival; Drug Interactions; Drug Resistance, Multiple; Etoposide; Flow Cytometry; Humans; Idarubicin; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Tumor Cells, Cultured; Verapamil | 1995 |
Sphinganine potentiation of cellular differentiation induced by various anti-leukemia drugs in human leukemia cell line HL-60.
Topics: Antineoplastic Agents; Calcium; Cell Differentiation; Cell Line; Egtazic Acid; Etoposide; Humans; Leukemia, Myeloid; Protein Kinase C; Sphingosine; Verapamil | 1994 |
Response of a multidrug-resistant human small-cell lung cancer xenograft to chemotherapy.
Topics: Adult; Animals; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Small Cell; Carrier Proteins; Cisplatin; Cyclophosphamide; Doxorubicin; Drug Resistance; Etoposide; Female; Flow Cytometry; Humans; Lung Neoplasms; Male; Membrane Glycoproteins; Mice; Mice, Nude; Neoplasm Proteins; Neoplasm Transplantation; Time Factors; Verapamil | 1993 |
Multiple mechanisms of resistance in a series of human testicular teratoma cell lines selected for increasing resistance to etoposide.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cell Survival; DNA; DNA Damage; DNA Topoisomerases, Type II; Drug Resistance; Etoposide; Humans; Male; Membrane Glycoproteins; Teratoma; Testicular Neoplasms; Tumor Cells, Cultured; Verapamil; Vincristine | 1994 |
Evaluation of multiple drug resistance in human bladder cancer cell lines.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Carrier Proteins; Doxorubicin; Drug Resistance; Drug Screening Assays, Antitumor; Etoposide; Humans; Membrane Glycoproteins; Neoplasm Proteins; Tumor Cells, Cultured; Urinary Bladder Neoplasms; Verapamil | 1993 |
Difference between the resistance mechanisms of aclacinomycin- and adriamycin-resistant P388 cell lines.
Topics: Aclarubicin; Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Nucleus; DNA Topoisomerases, Type II; DNA, Neoplasm; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Etoposide; Humans; Immunoblotting; Leukemia P388; Tumor Cells, Cultured; Verapamil; Vincristine | 1995 |
Adding a reverser (verapamil) to combined chemotherapy overrides resistance in small cell lung cancer xenografts.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Cisplatin; Cyclophosphamide; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Therapy, Combination; Etoposide; Female; Humans; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Transplantation, Heterologous; Verapamil | 1995 |
Non-P-glycoprotein-mediated atypical multidrug resistance in a human bladder cancer cell line.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Carcinoma, Transitional Cell; Cisplatin; DNA Topoisomerases, Type II; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Epirubicin; Etoposide; Fluorouracil; Humans; Mitomycin; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Selection, Genetic; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Urinary Bladder Neoplasms; Verapamil; Vinca Alkaloids | 1995 |
Degradation of radioiodinated B cell monoclonal antibodies: inhibition via a FCgamma-receptor-II-mediated mechanism and by drugs.
Topics: Animals; Antibodies, Monoclonal; Antigens, CD; Antigens, CD19; Antigens, Differentiation, B-Lymphocyte; Antineoplastic Agents; B-Lymphocytes; Biological Transport; Burkitt Lymphoma; Calcium Channel Blockers; Cell Adhesion Molecules; Chloroquine; Colchicine; Etoposide; Humans; Immunoglobulin Isotypes; Immunotoxins; Iodine Radioisotopes; Lectins; Leukemia, B-Cell; Mice; Monensin; Paclitaxel; Radioimmunotherapy; Receptors, IgG; Sialic Acid Binding Ig-like Lectin 2; Verapamil; Vinblastine; Vincristine | 1996 |
Down-regulation of apoptosis-related bcl-2 but not bcl-xL or bax proteins in multidrug-resistant MCF-7/Adr human breast cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Base Sequence; bcl-2-Associated X Protein; bcl-X Protein; Breast Neoplasms; Cyclosporine; Doxorubicin; Drug Resistance, Multiple; Etoposide; Gene Expression Regulation, Neoplastic; Humans; Molecular Sequence Data; Paclitaxel; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; Tumor Cells, Cultured; Verapamil; Vincristine | 1996 |
Complete restoration of glucocerebrosidase deficiency in Gaucher fibroblasts using a bicistronic MDR retrovirus and a new selection strategy.
Topics: Animals; Anthracenes; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Northern; Blotting, Western; Cells, Cultured; Colchicine; Cyclosporins; DNA, Complementary; Doxorubicin; Drug Resistance, Multiple; Etoposide; Fibroblasts; Gaucher Disease; Gene Expression Regulation; Genetic Therapy; Genetic Vectors; Glucosylceramidase; Humans; Mice; Mutagenesis, Insertional; Retroviridae; Transfection; Verapamil | 1996 |
The multidrug resistance-associated protein gene confers drug resistance in human gastric and colon cancers.
Topics: Antineoplastic Agents; Camptothecin; Cisplatin; Colonic Neoplasms; Doxorubicin; Etoposide; Genes, MDR; Humans; Irinotecan; Mitomycin; Polymerase Chain Reaction; RNA, Messenger; Stomach Neoplasms; Tumor Cells, Cultured; Verapamil; Vincristine | 1996 |
Chemosensitization and drug accumulation effects of VX-710, verapamil, cyclosporin A, MS-209 and GF120918 in multidrug resistant HL60/ADR cells expressing the multidrug resistance-associated protein MRP.
Topics: Acridines; Affinity Labels; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cyclosporine; Daunorubicin; Doxorubicin; Drug Resistance, Multiple; Etoposide; Fluoresceins; HL-60 Cells; Humans; Isoquinolines; Multidrug Resistance-Associated Proteins; Piperidines; Pyridines; Quinolines; Tetrahydroisoquinolines; Tritium; Verapamil; Vincristine | 1997 |
Multidrug resistance in androgen-independent growing rat prostate carcinoma cells is mediated by P-glycoprotein.
Topics: Androgens; Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Etoposide; Fluorescent Dyes; Genes, MDR; Male; Methotrexate; Neoplasms, Hormone-Dependent; Paclitaxel; Prostatic Neoplasms; Rats; Rhodamine 123; Rhodamines; Tumor Cells, Cultured; Verapamil; Vinblastine | 1997 |
Intermittent exposure to doxorubicin in vitro selects for multifactorial non-P-glycoprotein-associated multidrug resistance in RPMI 8226 human myeloma cells.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Doxorubicin; Drug Interactions; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Etoposide; Humans; Multiple Myeloma; Tumor Cells, Cultured; Verapamil; Vincristine | 1997 |
Differential stabilization of topoisomerase-II-DNA cleavable complexes by doxorubicin and etoposide in doxorubicin-resistant rat glioblastoma cells.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; DNA; DNA Damage; DNA Topoisomerases, Type II; Doxorubicin; Drug Resistance, Neoplasm; Enzyme Stability; Etoposide; Glioblastoma; Rats; Tumor Cells, Cultured; Verapamil | 1997 |
Expression of the multidrug resistance-associated protein gene in refractory lymphoma: quantitation by a validated polymerase chain reaction assay.
Topics: Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biopsy; Breast Neoplasms; Carcinoma, Small Cell; Cyclophosphamide; DNA, Neoplasm; Doxorubicin; Drug Resistance, Neoplasm; Etoposide; Gene Expression Regulation, Neoplastic; HL-60 Cells; Humans; Lung Neoplasms; Lymphoma; Neoplasm Proteins; Polymerase Chain Reaction; Prednisone; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured; Verapamil; Vincristine | 1997 |
Characterization of a Chinese hamster ovary cell line with acquired resistance to the bisdioxopiperazine dexrazoxane (ICRF-187) catalytic inhibitor of topoisomerase II.
Topics: Aclarubicin; Animals; CHO Cells; Cricetinae; DNA Topoisomerases, Type II; Drug Resistance; Ethylenediamines; Etoposide; Glycine; Mutation; Razoxane; Thiobarbiturates; Topoisomerase II Inhibitors; Verapamil | 1997 |
Role of the vacuolar H+-ATPase in daunorubicin distribution in etoposide-resistant MCF7 cells overexpressing the multidrug-resistance associated protein.
Topics: 4-Chloro-7-nitrobenzofurazan; Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Nucleus; Cholesterol; Cytoplasm; Daunorubicin; Drug Resistance, Multiple; Etoposide; Female; Humans; Norsteroids; Proton-Translocating ATPases; Tumor Cells, Cultured; Vacuolar Proton-Translocating ATPases; Verapamil | 1998 |
Multidrug resistance modulation in rhabdomyosarcoma and neuroblastoma cell lines.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Small Cell; Cell Survival; Cisplatin; Cyclophosphamide; Cyclosporine; Doxorubicin; Drug Resistance, Multiple; Etoposide; Humans; Kinetics; Lung Neoplasms; Methotrexate; Neuroblastoma; Rhabdomyosarcoma; Time Factors; Tumor Cells, Cultured; Verapamil; Vincristine | 1998 |
Characterization of the regional intestinal kinetics of drug efflux in rat and human intestine and in Caco-2 cells.
Topics: Adenosine Triphosphate; Animals; Caco-2 Cells; Colon; Etoposide; Humans; Ileum; Intestinal Mucosa; Jejunum; Protons; Rats; Sodium; Temperature; Verapamil; Vinblastine | 1998 |
Decreased drug accumulation without increased drug efflux in a novel MRP-overexpressing multidrug-resistant cell line.
Topics: Antineoplastic Agents; ATP-Binding Cassette Transporters; Cell Line; Doxorubicin; Drug Resistance, Multiple; Enzyme Inhibitors; Etoposide; Humans; KB Cells; Multidrug Resistance-Associated Proteins; Topoisomerase II Inhibitors; Verapamil; Vincristine | 1998 |
Swelling-activated chloride currents in a drug-sensitive cell line and a P glycoprotein-expressing derivative are underlied by channels with the same pharmacological properties.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Size; Chloride Channels; Colchicine; Cytochalasin D; Cytoskeleton; Electrophysiology; Etoposide; Humans; Hypertonic Solutions; Hypotonic Solutions; Meglumine; Nitrobenzenes; Tumor Cells, Cultured; Verapamil; Vinblastine | 1998 |
P-glycoprotein protects leukemia cells against caspase-dependent, but not caspase-independent, cell death.
Topics: Antibodies, Monoclonal; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caspases; Cytotoxicity, Immunologic; Dexamethasone; DNA, Complementary; Enzyme Inhibitors; Etoposide; Fas Ligand Protein; fas Receptor; Genes, MDR; Granzymes; Humans; Leukemia-Lymphoma, Adult T-Cell; Membrane Glycoproteins; Neoplasm Proteins; Perforin; Pore Forming Cytotoxic Proteins; Recombinant Proteins; Serine Endopeptidases; Transfection; Tumor Necrosis Factor-alpha; Tumor Stem Cell Assay; Ultraviolet Rays; Verapamil; Vinblastine | 1999 |
Comparison of the properties of human breast cancer cells: MCF-7 and MCF-7 cells selected for resistance to etoposide.
Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Chromatography, High Pressure Liquid; Dactinomycin; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Neoplasm; Etoposide; Flow Cytometry; Humans; Leukotriene Antagonists; Propionates; Protein Synthesis Inhibitors; Quinolines; Tumor Cells, Cultured; Vasodilator Agents; Verapamil; Vinblastine | 2001 |
Expression of P-glycoprotein and multidrug resistance associated protein in Ehrlich ascites tumor cells after fractionated irradiation.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Carcinoma, Ehrlich Tumor; Daunorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Etoposide; Glutathione; Mice; Neoplasm Proteins; Phenotype; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Tumor Stem Cell Assay; Verapamil; Vincristine | 2001 |
Retroviral transfer and expression of human MDR-1 in a murine haemopoietic stem cell line does not alter factor dependence, growth or differentiation characteristics.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cell Differentiation; Cell Division; Clone Cells; Culture Media, Conditioned; Drug Resistance, Neoplasm; Etoposide; Fluorescent Dyes; Genes, MDR; Hematopoietic Cell Growth Factors; Hematopoietic Stem Cells; Humans; Mice; Peptide Fragments; Receptors, Nerve Growth Factor; Recombinant Fusion Proteins; Rhodamines; Transfection; Verapamil | 2002 |
Lamellarin D: a novel pro-apoptotic agent from marine origin insensitive to P-glycoprotein-mediated drug efflux.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cell Cycle; Coumarins; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Etoposide; Fluoresceins; Heterocyclic Compounds, 4 or More Rings; Isoquinolines; Leukemia P388; Membrane Potentials; Mice; Mitochondria; Rhodamine 123; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Verapamil | 2005 |
Development of an on-line extraction turbulent flow chromatography tandem mass spectrometry method for cassette analysis of Caco-2 cell based bi-directional assay samples.
Topics: Biological Transport; Caco-2 Cells; Cell Membrane Permeability; Chromatography, High Pressure Liquid; Dexamethasone; Etoposide; Furosemide; Humans; Metoprolol; Nadolol; Pharmaceutical Preparations; Propranolol; Quinidine; Rhodamine 123; Spectrometry, Mass, Electrospray Ionization; Sulfasalazine; Verapamil | 2006 |
Selection of non-P-glycoprotein mediated high-level etoposide resistant cell lines by adriamycin with P-gp inhibitors.
Topics: Animals; Antigens, Neoplasm; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Blotting, Western; Cell Line, Tumor; Cell Survival; Cyclosporins; Daunorubicin; DNA Topoisomerases, Type II; DNA-Binding Proteins; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Etoposide; Gene Expression Regulation, Neoplastic; Mice; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Verapamil | 2006 |
Induced resistance in the human non small cell lung carcinoma (NCI-H460) cell line in vitro by anticancer drugs.
Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Curcumin; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Etoposide; Glutathione Transferase; Humans; Lung Neoplasms; Multidrug Resistance-Associated Proteins; Paclitaxel; Rhodamines; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured; Verapamil; Vinblastine | 2006 |
The sea urchin embryo as a model for studying efflux transporters: roles and energy cost.
Topics: Animals; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Division; Cyclosporins; Cytotoxins; Embryo, Nonmammalian; Energy Metabolism; Etoposide; Fluoresceins; Membrane Transport Proteins; Models, Animal; Propionates; Quinolines; Sea Urchins; Verapamil; Vinblastine | 2006 |
The synthesis and characterization of cellular membrane affinity chromatography columns for the study of human multidrug resistant proteins MRP1, MRP2 and human breast cancer resistant protein BCRP using membranes obtained from Spodoptera frugiperda (Sf9)
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cell Line; Cell Membrane; Chromatography; Etoposide; Humans; Inhibitory Concentration 50; Insecta; Kinetics; Ligands; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Stereoisomerism; Verapamil | 2010 |
20(S)-ginsenoside Rh2 noncompetitively inhibits P-glycoprotein in vitro and in vivo: a case for herb-drug interactions.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Digoxin; Etoposide; Ginsenosides; Herb-Drug Interactions; Humans; Ileum; Male; Rats; Rats, Sprague-Dawley; Rhodamine 123; Terfenadine; Verapamil | 2010 |
Enhancing effect of N-octyl-O-sulfate chitosan on etoposide absorption.
Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Chitosan; Etoposide; Excipients; Humans; Intestinal Absorption; Micelles; Rats; Rats, Sprague-Dawley; Solubility; Verapamil | 2011 |
Enhanced intestinal absorption of etoposide by self-microemulsifying drug delivery systems: roles of P-glycoprotein and cytochrome P450 3A inhibition.
Topics: Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Caco-2 Cells; Cell Survival; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Delivery Systems; Etoposide; Humans; Intestinal Absorption; Ketoconazole; Male; Rats; Rats, Sprague-Dawley; Verapamil | 2013 |
Characterization of a multiple endogenously expressed adenosine triphosphate-binding cassette transporters using nuclear and cellular membrane affinity chromatography columns.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cell Line, Tumor; Cell Membrane; Chromatography, Affinity; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Estrone; Etoposide; Glioblastoma; Humans; Ligands; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Nuclear Envelope; Prazosin; Protein Binding; Verapamil | 2014 |
Disruption of the association between drug transporter and actin cytoskeleton abolishes drug resistance in hypertrophic scar.
Topics: Actin Cytoskeleton; Adolescent; Adult; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Cicatrix, Hypertrophic; Drug Resistance; Etoposide; Female; Fibroblasts; Gene Expression Regulation; Humans; Male; Multidrug Resistance-Associated Proteins; Organophosphorus Compounds; Skin; Verapamil; Young Adult | 2017 |
A role for ABCB1 in prognosis, invasion and drug resistance in ependymoma.
Topics: ATP Binding Cassette Transporter, Subfamily B; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Child, Preschool; Drug Resistance, Neoplasm; Drug Synergism; Ependymoma; Etoposide; Gene Expression Regulation, Neoplastic; Humans; Infant; Methotrexate; Neoplasm Invasiveness; Neoplastic Stem Cells; Prognosis; Survival Analysis; Up-Regulation; Vardenafil Dihydrochloride; Verapamil; Vincristine | 2019 |