etoposide has been researched along with serine in 39 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (12.82) | 18.2507 |
| 2000's | 14 (35.90) | 29.6817 |
| 2010's | 17 (43.59) | 24.3611 |
| 2020's | 3 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Elsea, SH; Hsiung, Y; Nitiss, JL; Osheroff, N | 1 |
| Carr, B; Deng, X; Ito, T; May, WS | 1 |
| Cole, SP; Falck, J; Jensen, PB; Mirski, SE; Sehested, M; Wessel, I | 1 |
| Ikeda, M; Levine, AJ; Lu, H; Taya, Y | 1 |
| Nicklaus, MC; Nitiss, JL; Pommier, Y; Rose, A; Strumberg, D | 1 |
| Chang, NS | 1 |
| Penzo, D; Pinna, LA; Ruzzene, M | 1 |
| Ishida, E; Kishi, M; Konishi, N; Nakamura, M; Shimada, K; Yonehara, S | 1 |
| La Thangue, NB; Smith, L; Stevens, C | 1 |
| Ding, H; Duan, W; Ju, R; Otterson, GA; Srinivasan, K; Villalona-Calero, MA; Zhu, WG | 1 |
| Shacter, E; Zhang, B; Zhang, Y | 1 |
| Carvajal, D; Heimbrook, DC; Thompson, T; Tovar, C; Vassilev, LT; Vu, BT; Wahl, GM; Xu, Q; Yang, H | 1 |
| Donner, DB; Jackson, MW; Korgaonkar, CK; Mayo, LD; Rivera Guzman, J; Seo, YR; Smith, ML | 1 |
| Beurel, E; Blivet-Van Eggelpoël, MJ; Cadoret, A; Capeau, J; Desbois-Mouthon, C; Kornprobst, M | 1 |
| Kothapalli, N; Sarath, G; Zempleni, J | 1 |
| Chang, NS; Doherty, J; Ensign, A; Hong, Q; Hsu, LJ; Schultz, L | 1 |
| Costa, RH; Raychaudhuri, P; Tan, Y | 1 |
| Huang, CY; Huang, EY; Lin, WJ; Lu, YL; Wang, CF; Wang, WL; Yeh, SF | 1 |
| Andersen, AH; Bukowski, RM; Chikamori, K; Ganapathi, MK; Ganapathi, R; Grabowski, DR; Grozav, AG; Kinter, M; Kozuki, T; Willard, B | 1 |
| Hailemariam, K; Huang, BW; Iwasaki, K; Ninomiya-Tsuji, J; Sakamoto, K; Tsuji, Y | 1 |
| Delston, RB; Harbour, JW; Matatall, KA; Onken, MD; Sun, Y | 1 |
| Bode, AM; Cho, YY; Dong, Z; Keum, YS; Ma, WY; Peng, C; Wen, W; Yao, K; Zhang, J; Zheng, D; Zhu, F; Zykova, T | 1 |
| Choi, BH; Jeong, MW; Kim, KT; Kim, S; Kim, W; Park, CH; Song, YS | 1 |
| Gilbert, B; Janssen-Megens, E; Koeppel, M; Lohrum, M; Smeenk, L; Stunnenberg, HG; van Heeringen, SJ | 1 |
| Baba, M; Kato, K; Kodama, T; Kudo, T; Maruyama, D; Morihara, T; Okochi, M; Sadik, G; Tagami, S; Takeda, M; Tanaka, T; Yanagida, K | 1 |
| Arnold, CR; Brunner, S; Bürkle, A; Grillari, J; Grubeck-Loebenstein, B; Hackl, M; Herndler-Brandstetter, D; Moreno-Villanueva, M; Villunger, A; Wiegers, GJ | 1 |
| Choi, JS; Joo, SH; Lee, SK; Na, M; Oh, JI | 1 |
| He, K; Huang, YH; Jiang, D; Jin, YH; Li, Y; Sun, C; Zhan, Z; Zhu, D | 1 |
| Mizutani, S; Porter, AC; Sato, M; Shimizu, T; Takagi, M; Tamaichi, H | 1 |
| Battu, A; Gong, L; Han, C; Racoma, I; Sharma, N; Wang, QE; Wani, AA; Wani, G; Zhao, R; Zhu, Q | 1 |
| Chun, KS; Jeong, CH; Kundu, J; Park, B | 1 |
| Ching, YP; Hung, WY; Lai, WL | 1 |
| Bohr, VA; Ghosh, D; Karmakar, P; Kusumoto-Matsuo, R; May, A; Ramsden, D | 1 |
| Cox, M; Loughery, J; Meek, DW; Smith, LM | 1 |
| Karmakar, P; Misra, S; Mukherjee, A | 1 |
| Bernas, T; Berniak, K; Bujnowicz, L; Darzynkiewicz, Z; Dobrucki, J; Hoang, A; Rybak, P; Zarębski, M | 1 |
| Arakawa, S; Honda, S; Moriwaki, K; Nakanishi, A; Nakano, H; Shimizu, S; Torii, S; Yamaguchi, H | 1 |
| Chong, SJF; Collins, M; Davids, M; Herbaux, C; Iskandar, K; Lai, JXH; Loh, T; Low, ICC; Pervaiz, S; Qu, J; Raman, D; Valentin, R | 1 |
| Hirsch, I; Hodek, J; Krulova, K; Lubyova, B; Tikalova, E; Weber, J; Zabransky, A | 1 |
39 other study(ies) available for etoposide and serine
| Article | Year |
|---|---|
A mutation in yeast TOP2 homologous to a quinolone-resistant mutation in bacteria. Mutation of the amino acid homologous to Ser83 of Escherichia coli gyrA alters sensitivity to eukaryotic topoisomerase inhibitors.
Topics: Anti-Infective Agents; Base Sequence; DNA Topoisomerases, Type II; Drug Resistance, Microbial; Escherichia coli; Etoposide; Fluoroquinolones; Genes, Bacterial; Genes, Fungal; Kinetics; Macromolecular Substances; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Point Mutation; Quinolones; Recombinant Proteins; Saccharomyces cerevisiae; Serine; Species Specificity; Tryptophan | 1995 |
Bcl-2 phosphorylation required for anti-apoptosis function.
Topics: Alanine; Animals; Apoptosis; Bryostatins; Cell Line; Dimerization; Enzyme Activation; Etoposide; Glutamic Acid; Interleukin-3; Kinetics; Lactones; Macrolides; Mice; Mutagenesis, Site-Directed; Phosphates; Phosphorylation; Point Mutation; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; Recombinant Proteins; Serine; Transfection | 1997 |
Loss of amino acids 1490Lys-Ser-Lys1492 in the COOH-terminal region of topoisomerase IIalpha in human small cell lung cancer cells selected for resistance to etoposide results in an extranuclear enzyme localization.
Topics: Amino Acid Sequence; Amino Acid Substitution; Antigens, Neoplasm; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Carcinoma, Small Cell; Cell Nucleus; Consensus Sequence; DNA Topoisomerases, Type II; DNA-Binding Proteins; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Etoposide; Humans; Isoenzymes; Lung Neoplasms; Lysine; Molecular Sequence Data; Molecular Weight; Multidrug Resistance-Associated Proteins; Peptide Fragments; Point Mutation; Polymerase Chain Reaction; RNA, Messenger; Sequence Deletion; Serine; Tumor Cells, Cultured | 1997 |
Ultraviolet radiation, but not gamma radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389.
Topics: Animals; Antineoplastic Agents, Phytogenic; DNA Damage; Etoposide; Gamma Rays; Humans; Male; Mice; Neoplasms, Experimental; Phosphorylation; Serine; Testicular Neoplasms; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Ultraviolet Rays | 1998 |
Mutation of a conserved serine residue in a quinolone-resistant type II topoisomerase alters the enzyme-DNA and drug interactions.
Topics: Amino Acid Substitution; Base Sequence; DNA; DNA Primers; DNA Topoisomerases, Type II; Enzyme Stability; Etoposide; Hot Temperature; Hydrolysis; Protein Conformation; Quinolones; Recombinant Proteins; Salts; Serine | 1999 |
The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression.
Topics: Animals; Ankyrins; Apoptosis; Cell Division; Cell Line; Cell Nucleus; COS Cells; Cytosol; DNA Damage; DNA-Binding Proteins; Dose-Response Relationship, Drug; Down-Regulation; Etoposide; Genes, Dominant; Humans; Hyaluronoglucosaminidase; Hypoxia; I-kappa B Proteins; Liver; Mice; Microscopy, Fluorescence; Mutagenesis, Site-Directed; NF-KappaB Inhibitor alpha; Phosphorylation; Precipitin Tests; Proline; Protein Binding; Protein Structure, Tertiary; Rats; Recombinant Proteins; Serine; Spleen; Staurosporine; Threonine; Time Factors; Transfection; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Ultraviolet Rays | 2002 |
Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells.
Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Blood Proteins; Casein Kinase II; Caspase 3; Caspases; Cell Death; Cell Survival; Cytochrome c Group; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Etoposide; Humans; Jurkat Cells; Phosphorylation; Poly(ADP-ribose) Polymerases; Precipitin Tests; Protein Binding; Protein Serine-Threonine Kinases; Serine; Threonine; Time Factors; Triazoles; Tyrosine | 2002 |
Phosphorylation of Fas-associated death domain contributes to enhancement of etoposide-induced apoptosis in prostate cancer cells.
Topics: Adaptor Proteins, Signal Transducing; Apoptosis; bcl-X Protein; Carrier Proteins; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase 3; Caspases; Cell Cycle; Enzyme Activation; Etoposide; Fas-Associated Death Domain Protein; Humans; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Male; Mitogen-Activated Protein Kinases; Phosphorylation; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Serine; Tumor Cells, Cultured | 2002 |
Chk2 activates E2F-1 in response to DNA damage.
Topics: Apoptosis; Cell Cycle; Cell Cycle Proteins; Cell Nucleus; Checkpoint Kinase 2; DNA Damage; DNA-Binding Proteins; E2F Transcription Factors; E2F1 Transcription Factor; Etoposide; Eukaryotic Cells; Gene Expression Regulation, Neoplastic; Humans; Mutation; Nucleic Acid Synthesis Inhibitors; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Serine; Signal Transduction; Transcription Factors; Transcriptional Activation; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2003 |
P21 response to DNA damage induced by genistein and etoposide in human lung cancer cells.
Topics: Antineoplastic Agents; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Damage; DNA-Binding Proteins; Enzyme Inhibitors; Etoposide; Genistein; Humans; Lung Neoplasms; Phosphorylation; Protein Serine-Threonine Kinases; Serine; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2003 |
Rac1 inhibits apoptosis in human lymphoma cells by stimulating Bad phosphorylation on Ser-75.
Topics: Animals; Apoptosis; bcl-Associated Death Protein; Carrier Proteins; Caspases; Cell Line, Tumor; Cell Survival; Cyclic AMP-Dependent Protein Kinases; Drug Resistance, Neoplasm; Enzyme Activation; Etoposide; Humans; Lymphoma; Mice; Nucleic Acid Synthesis Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; rac1 GTP-Binding Protein; Recombinant Fusion Proteins; Serine; Signal Transduction | 2004 |
Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis.
Topics: Annexin A5; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Cell Line, Tumor; Coloring Agents; DNA; Dose-Response Relationship, Drug; Doxorubicin; Enzyme-Linked Immunosorbent Assay; Etoposide; Humans; Imidazoles; Kinetics; Nuclear Proteins; Phosphorylation; Piperazines; Polymerase Chain Reaction; Protein Binding; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Serine; Transcriptional Activation; Tumor Suppressor Protein p53 | 2004 |
Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified.
Topics: Antineoplastic Agents; Apoptosis; Cell Death; Cell Line, Tumor; Comet Assay; DNA Damage; Etoposide; Feedback, Physiological; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Immunoblotting; Mutation; Nuclear Proteins; Phosphoric Monoester Hydrolases; Phosphorylation; Promoter Regions, Genetic; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; PTEN Phosphohydrolase; Reverse Transcriptase Polymerase Chain Reaction; RNA; Serine; Time Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2005 |
GSK-3beta reactivation with LY294002 sensitizes hepatoma cells to chemotherapy-induced apoptosis.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Camptothecin; Carcinoma, Hepatocellular; Caspase 3; Caspase 8; Caspases; Cell Line, Tumor; Chromones; Cytochromes c; DNA Fragmentation; Enzyme Activation; Enzyme Inhibitors; Etoposide; fas Receptor; Flow Cytometry; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Morpholines; Mutation; Phosphatidylinositol 3-Kinases; Phosphorylation; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Reverse Transcriptase Polymerase Chain Reaction; Serine; Transfection; Tumor Suppressor Protein p53 | 2005 |
Biotinylation of K12 in histone H4 decreases in response to DNA double-strand breaks in human JAr choriocarcinoma cells.
Topics: Antineoplastic Agents, Phytogenic; Biotin; Biotinylation; Cell Survival; Choriocarcinoma; DNA; DNA Damage; Etoposide; Histones; Humans; Jurkat Cells; Lysine; Phosphorylation; Pyrimidine Dimers; Serine; Signal Transduction | 2005 |
WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53.
Topics: Active Transport, Cell Nucleus; Animals; Anisomycin; Cell Line, Tumor; Cell Nucleus; Cytoplasm; Cytosol; DNA, Complementary; Dose-Response Relationship, Drug; Etoposide; Fibroblasts; Genes, Dominant; Humans; Hypoxia; Imidazoles; Immunoprecipitation; Luminescent Proteins; Mice; Microscopy, Fluorescence; Models, Biological; Oxidoreductases; Phosphorylation; Piperazines; Proteasome Endopeptidase Complex; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine; Staurosporine; Time Factors; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Two-Hybrid System Techniques; Tyrosine; U937 Cells; Ultraviolet Rays; WW Domain-Containing Oxidoreductase | 2005 |
Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes.
Topics: Amino Acid Sequence; Animals; BRCA2 Protein; Checkpoint Kinase 2; DNA Breaks; DNA Repair; DNA-Binding Proteins; Etoposide; Fibroblasts; Forkhead Box Protein M1; Forkhead Transcription Factors; Gene Expression Regulation; Humans; Infrared Rays; Mice; Molecular Sequence Data; Phosphorylation; Protein Serine-Threonine Kinases; Serine; Signal Transduction; Thermodynamics; Transcription, Genetic; Tumor Suppressor Protein p53; Ultraviolet Rays; X-ray Repair Cross Complementing Protein 1 | 2007 |
Mitochondrial anchoring of PKCalpha by PICK1 confers resistance to etoposide-induced apoptosis.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Carbazoles; Carrier Proteins; Cell Cycle Proteins; Cell Line; Dimerization; Enzyme Inhibitors; Etoposide; Humans; Indoles; Mice; Mitochondria; NIH 3T3 Cells; Nuclear Proteins; Peptides; Protein Kinase C-alpha; Proto-Oncogene Proteins c-bcl-2; Serine | 2007 |
Casein kinase I delta/epsilon phosphorylates topoisomerase IIalpha at serine-1106 and modulates DNA cleavage activity.
Topics: Antigens, Neoplasm; Casein Kinase 1 epsilon; Casein Kinase I; Casein Kinase Idelta; DNA Cleavage; DNA Topoisomerases, Type II; DNA-Binding Proteins; Down-Regulation; Etoposide; HL-60 Cells; Humans; Peptides; Phosphorylation; Protein Kinase Inhibitors; RNA Interference; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine; Transformation, Genetic | 2009 |
Regulation of genotoxic stress response by homeodomain-interacting protein kinase 2 through phosphorylation of cyclic AMP response element-binding protein at serine 271.
Topics: Animals; Antineoplastic Agents, Phytogenic; Blotting, Western; Brain-Derived Neurotrophic Factor; Carrier Proteins; Cell Line, Tumor; Cells, Cultured; CREB-Binding Protein; Cyclic AMP Response Element-Binding Protein; DNA Damage; Embryo, Mammalian; Etoposide; Fibroblasts; HEK293 Cells; Humans; K562 Cells; Mice; Mice, Knockout; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; RNA Interference; Serine; Transcription, Genetic; Two-Hybrid System Techniques | 2010 |
p38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosis.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Cell Line, Tumor; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; E2F1 Transcription Factor; Etoposide; Humans; Immunoblotting; Mitogen-Activated Protein Kinase 14; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Binding; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-mdm2; Purines; Retinoblastoma Protein; RNA Interference; Roscovitine; Serine; Tumor Suppressor Protein p53 | 2011 |
MST1 promotes apoptosis through phosphorylation of histone H2AX.
Topics: Apoptosis; Chromatin; DNA Fragmentation; Etoposide; Gene Expression Regulation, Neoplastic; HEK293 Cells; HeLa Cells; Hepatocyte Growth Factor; Histones; Humans; Jurkat Cells; Phosphorylation; Proto-Oncogene Proteins; Serine | 2010 |
Protein kinase Cδ regulates vaccinia-related kinase 1 in DNA damage-induced apoptosis.
Topics: Animals; Apoptosis; Cell Cycle; Cell Line, Transformed; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Cell Survival; Cloning, Molecular; Cricetinae; DNA Damage; Electroporation; Escherichia coli; Etoposide; Female; Gene Expression Regulation; Gene Silencing; Humans; Mice; Mutation; Phosphorylation; Protein Kinase C-delta; Protein Serine-Threonine Kinases; Recombinant Fusion Proteins; RNA, Small Interfering; Serine; Tumor Suppressor Protein p53 | 2011 |
Role of p53 serine 46 in p53 target gene regulation.
Topics: Binding Sites; Cell Line, Tumor; Chromatin; Chromatin Immunoprecipitation; Cluster Analysis; Dactinomycin; DNA; Etoposide; Gene Expression Regulation, Neoplastic; Genome, Human; Humans; Molecular Sequence Annotation; Phosphorylation; Phosphoserine; Protein Binding; Sequence Analysis, Protein; Serine; Structure-Activity Relationship; Tumor Suppressor Protein p53 | 2011 |
Protein kinase C stabilizes X-linked inhibitor of apoptosis protein (XIAP) through phosphorylation at Ser(87) to suppress apoptotic cell death.
Topics: Alzheimer Disease; Antineoplastic Agents, Phytogenic; Apoptosis; Brain; Cell Death; Cell Line, Tumor; Etoposide; Humans; Neuroblastoma; Neurons; Phosphorylation; Protein Kinase C; Serine; Tetradecanoylphorbol Acetate; Transfection; X-Linked Inhibitor of Apoptosis Protein | 2011 |
Upregulation of miR-24 is associated with a decreased DNA damage response upon etoposide treatment in highly differentiated CD8(+) T cells sensitizing them to apoptotic cell death.
Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Apoptosis; CD28 Antigens; CD8-Positive T-Lymphocytes; Cell Differentiation; DNA Damage; DNA Repair; Etoposide; Histones; Humans; In Vitro Techniques; Interleukin-15; Jurkat Cells; MicroRNAs; Phosphorylation; Serine; Signal Transduction; Up-Regulation | 2012 |
PKCδ promotes etoposide-induced cell death by phosphorylating Hsp27 in HeLa cells.
Topics: Apoptosis; Caspase 3; Cytochromes c; Etoposide; HeLa Cells; HSP27 Heat-Shock Proteins; Humans; Protein Kinase C-delta; Proteolysis; Recombinant Proteins; Serine | 2012 |
Phosphorylation of Rad9 at serine 328 by cyclin A-Cdk2 triggers apoptosis via interfering Bcl-xL.
Topics: Active Transport, Cell Nucleus; Apoptosis; bcl-X Protein; Biocatalysis; Cell Cycle Proteins; Cell Nucleus; Cyclin A; Cyclin-Dependent Kinase 2; Etoposide; HeLa Cells; Humans; Mitochondria; Phosphorylation; RNA Interference; Serine; Signal Transduction; Topoisomerase II Inhibitors; Up-Regulation | 2012 |
Ataxia telangiectasia mutated-dependent regulation of topoisomerase II alpha expression and sensitivity to topoisomerase II inhibitor.
Topics: Alanine; Antigens, Neoplasm; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; DNA Damage; DNA Topoisomerases, Type II; DNA-Binding Proteins; Etoposide; Histone-Lysine N-Methyltransferase; Humans; Leukemia; Mutagenesis, Site-Directed; Myeloid-Lymphoid Leukemia Protein; Phosphorylation; Poly-ADP-Ribose Binding Proteins; Protein Serine-Threonine Kinases; Serine; Topoisomerase II Inhibitors; Tumor Suppressor Proteins | 2013 |
p38 MAPK- and Akt-mediated p300 phosphorylation regulates its degradation to facilitate nucleotide excision repair.
Topics: Cell Line; Chromatin; Cisplatin; CREB-Binding Protein; DNA Damage; DNA Repair; DNA-Binding Proteins; Etoposide; Humans; p300-CBP Transcription Factors; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proteolysis; Proto-Oncogene Proteins c-akt; Radiation, Ionizing; Serine; Ultraviolet Rays | 2013 |
Phosphorylation of Smac by Akt promotes the caspase-3 activation during etoposide-induced apoptosis in HeLa cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Caspase 3; Cell Proliferation; Etoposide; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Intracellular Signaling Peptides and Proteins; Mitochondrial Proteins; Phosphorylation; Proto-Oncogene Proteins c-akt; Serine; Signal Transduction; X-Linked Inhibitor of Apoptosis Protein | 2015 |
The tumor suppressor, TAX1BP2, is a novel substrate of ATM kinase.
Topics: Antineoplastic Agents; Ataxia Telangiectasia Mutated Proteins; Blotting, Western; Cell Line, Tumor; Cisplatin; Etoposide; Gene Expression Regulation, Neoplastic; HEK293 Cells; Hep G2 Cells; Humans; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Morpholines; Mutation; Phosphorylation; Pyrones; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Serine; Substrate Specificity; Tumor Suppressor Proteins; Ubiquitination | 2014 |
Serines 440 and 467 in the Werner syndrome protein are phosphorylated by DNA-PK and affects its dynamics in response to DNA double strand breaks.
Topics: Bleomycin; Cell Nucleolus; DNA Breaks, Double-Stranded; DNA Repair; DNA-Activated Protein Kinase; Dose-Response Relationship, Drug; Etoposide; Exodeoxyribonucleases; HEK293 Cells; HeLa Cells; Humans; Kinetics; Mutation; Nuclear Proteins; Phosphorylation; Protein Processing, Post-Translational; RecQ Helicases; Serine; Transfection; Werner Syndrome Helicase | 2014 |
Critical role for p53-serine 15 phosphorylation in stimulating transactivation at p53-responsive promoters.
Topics: Cell Line, Tumor; Chromatin; DNA Damage; Etoposide; Humans; Imidazoles; Mutation; Phosphorylation; Piperazines; Promoter Regions, Genetic; Serine; Transcriptional Activation; Tumor Suppressor Protein p53 | 2014 |
Phosphorylation of PTEN at STT motif is associated with DNA damage response.
Topics: Amino Acid Sequence; Cells, Cultured; DNA Damage; DNA Repair; Etoposide; HEK293 Cells; Humans; Phosphorylation; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; PTEN Phosphohydrolase; Serine; Threonine | 2014 |
Low level phosphorylation of histone H2AX on serine 139 (γH2AX) is not associated with DNA double-strand breaks.
Topics: A549 Cells; Camptothecin; DNA Breaks, Double-Stranded; DNA Damage; Etoposide; Histones; Humans; Microscopy, Confocal; Mitoxantrone; Phosphorylation; Serine; Tumor Suppressor p53-Binding Protein 1 | 2016 |
Identification of a phosphorylation site on Ulk1 required for genotoxic stress-induced alternative autophagy.
Topics: Amino Acid Sequence; Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Binding Sites; Cells, Cultured; DNA Damage; Embryo, Mammalian; Etoposide; Fibroblasts; Golgi Apparatus; Green Fluorescent Proteins; Mice, Knockout; Microscopy, Confocal; Phosphorylation; Receptor-Interacting Protein Serine-Threonine Kinases; Sequence Homology, Amino Acid; Serine | 2020 |
Serine-70 phosphorylated Bcl-2 prevents oxidative stress-induced DNA damage by modulating the mitochondrial redox metabolism.
Topics: Apoptosis; Cell Proliferation; Cisplatin; DNA Damage; Doxorubicin; Drug Resistance, Neoplasm; Etoposide; Fluorouracil; Humans; Jurkat Cells; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma; Mitochondria; Oxidation-Reduction; Oxidative Stress; Phosphorylation; Primary Cell Culture; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Serine | 2020 |
ATM-Dependent Phosphorylation of Hepatitis B Core Protein in Response to Genotoxic Stress.
Topics: Amino Acid Motifs; Ataxia Telangiectasia Mutated Proteins; Checkpoint Kinase 2; Cytoplasm; DNA Damage; Etoposide; Hep G2 Cells; Hepatitis B e Antigens; Hepatitis B virus; Hepatocytes; Humans; Hydrogen Peroxide; Phosphorylation; Serine; Trans-Activators; Viral Core Proteins; Viral Regulatory and Accessory Proteins; Virus Replication | 2021 |