Page last updated: 2024-08-23

etoposide and novobiocin

etoposide has been researched along with novobiocin in 51 studies

Research

Studies (51)

TimeframeStudies, this research(%)All Research%
pre-199010 (19.61)18.7374
1990's22 (43.14)18.2507
2000's7 (13.73)29.6817
2010's12 (23.53)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hansch, C; Khwaja, TA; Selassie, CD1
Barrows, LR; Ireland, CM; Kokoshka, JM1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ghosh, I; Manoharlal, R; Prakash, O; Prasad, R; Puri, N; Sharma, M1
Ekins, S; Williams, AJ; Xu, JJ1
Jun, KY; Jung, MJ; Kwon, Y; Lee, ES; Lee, EY; Lee, OH; Na, Y; Park Choo, HY1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Chang, IH; Jun, KY; Kwon, Y; Lee, E; Lee, ES; Na, Y; Park, SE1
Bist, G; Jun, KY; Kadayat, TM; Kwon, Y; Lee, ES; Park, S; Shrestha, A; Thapa Magar, TB1
Benedetto Tiz, D; Draskovits, G; Durante Cruz, C; Durcik, M; Ilaš, J; Kikelj, D; Lovison, D; Nyerges, Á; Pál, C; Peterlin Mašič, L; Skok, Ž; Tammela, P; Tomašič, T; Zidar, N1
Cruz, CD; Draskovits, G; Durcik, M; Ilaš, J; Kikelj, D; Mašič, LP; Nyerges, Á; Pál, C; Révész, T; Skok, Ž; Tammela, P; Tiz, DB; Tomašič, T; Zega, A; Zidar, N; Žigon, D1
Lorico, A; Rappa, G; Sartorelli, AC4
Constantinou, A; Grdina, D; Huberman, E; Kiguchi, K1
Aller, P; Bernabeu, C; Cabañas, C; Mata, F; Rius, C; Zorrilla, AR1
Elkind, MM; Shibuya, ML; Utsumi, H1
Andrews, PA; Howell, SB; Katz, EJ; Kling, KM; Vick, JS1
Bohr, V; Hanawalt, P; Mansbridge, J1
Kort, L; Rowley, R1
Denyer, SP; Dewick, PM; Figgitt, DP; Jackson, DE; Williams, P1
Forterre, P; Sioud, M1
Downes, CS; Johnson, RT; Mullinger, AM1
Duguet, M; Jaxel, C; Mirambeau, G; Panijel, J; Portemer, C; Taudou, G1
Beerman, TA; Sigmund, RD; Woynarowski, JM1
Baldacci, G; de Recondo, AM; Forterre, P; Sioud, M1
Liu, LF; Rowe, TC; Yang, L1
Lönn, S; Lönn, U1
Deisher, TA; Harlan, JM; Kaushansky, K1
Catapano, CV; Fernandes, DJ; Germino, JF; Lorico, A; Rappa, G; Sartorelli, AC; Srimatkandada, S1
Forsgren, A; Riesbeck, K1
Holden, SA; Northey, D; Robinson, MF; Rosowsky, A; Teicher, BA1
Filatov, MV; Varfolomeeva, EY1
Macfarlane, DE; O'Donnell, PS1
Corbett, AH; Osheroff, N; Robinson, MJ1
Corbett, AH; Hong, D; Osheroff, N1
McCabe, MJ; Orrenius, S1
Cattan, AR; Douglas, EA; Levett, D; Middleton, PG; Taylor, PR1
Falaschi, A; Ochem, A; Phan, TN; Tuteja, N; Tuteja, R1
Phan, TN; Tuteja, N1
Johnson, LM; Lorico, A; Murren, JR; Rappa, G; Sartorelli, AC1
Fodstad, O; Lorico, A; Rappa, G; Sartorelli, AC; Shyam, K1
Cavalcanti, DP; de Souza, W; Fragoso, SP; Goldenberg, S; Motta, MC1
Boudabous, A; Cekaite, L; Sioud, M1
Pham, XH; Tran, NQ; Tuteja, N; Tuteja, R1

Reviews

1 review(s) available for etoposide and novobiocin

ArticleYear
Membrane transporters in drug development.
    Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3

    Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs

2010

Other Studies

50 other study(ies) available for etoposide and novobiocin

ArticleYear
Structure-activity relationships of antineoplastic agents in multidrug resistance.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:7

    Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Cricetinae; Dactinomycin; Drug Resistance; Leukemia L1210; Mice; Regression Analysis; Structure-Activity Relationship; Tumor Cells, Cultured

1990
Cell-based screen for identification of inhibitors of tubulin polymerization.
    Journal of natural products, 1996, Volume: 59, Issue:12

    Topics: Animals; Brain Neoplasms; Bucladesine; Cell Differentiation; Drug Screening Assays, Antitumor; Formazans; Glioma; Rats; Tubulin; Tumor Cells, Cultured

1996
Cheminformatic models to predict binding affinities to human serum albumin.
    Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25

    Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids

2001
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:11

    Topics: Candida albicans; Membrane Transport Proteins; Saccharomyces cerevisiae; Structure-Activity Relationship; Substrate Specificity

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Synthesis, biological evaluation, and molecular docking study of 3-(3'-heteroatom substituted-2'-hydroxy-1'-propyloxy) xanthone analogues as novel topoisomerase IIα catalytic inhibitor.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:6

    Topics: Antigens, Neoplasm; Antineoplastic Agents; Biocatalysis; Cell Line, Tumor; Cell Survival; DNA Topoisomerases, Type II; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HeLa Cells; HL-60 Cells; Humans; Models, Molecular; Molecular Structure; Stereoisomerism; Structure-Activity Relationship; Topoisomerase II Inhibitors; Xanthones

2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
3-(3-Butylamino-2-hydroxy-propoxy)-1-hydroxy-xanthen-9-one acts as a topoisomerase IIα catalytic inhibitor with low DNA damage.
    European journal of medicinal chemistry, 2013, Volume: 69

    Topics: Antigens, Neoplasm; Antineoplastic Agents; Biocatalysis; Cell Line, Tumor; Cell Proliferation; DNA Damage; DNA Topoisomerases, Type II; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Structure-Activity Relationship; Topoisomerase II Inhibitors; Xanthones

2013
Novel 2-aryl-4-(4'-hydroxyphenyl)-5H-indeno[1,2-b]pyridines as potent DNA non-intercalative topoisomerase catalytic inhibitors.
    European journal of medicinal chemistry, 2017, Jan-05, Volume: 125

    Topics: Antigens, Neoplasm; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; DNA; DNA Topoisomerases, Type II; DNA-Binding Proteins; Humans; Molecular Docking Simulation; Pyridines; Structure-Activity Relationship; Topoisomerase II Inhibitors

2017
New N-phenylpyrrolamide DNA gyrase B inhibitors: Optimization of efficacy and antibacterial activity.
    European journal of medicinal chemistry, 2018, Jun-25, Volume: 154

    Topics: Amides; Anti-Bacterial Agents; DNA Gyrase; Dose-Response Relationship, Drug; Enterococcus faecalis; Escherichia coli; Microbial Sensitivity Tests; Molecular Structure; Pyrroles; Staphylococcus aureus; Structure-Activity Relationship; Topoisomerase II Inhibitors

2018
An optimised series of substituted N-phenylpyrrolamides as DNA gyrase B inhibitors.
    European journal of medicinal chemistry, 2019, Apr-01, Volume: 167

    Topics: Amides; Anti-Bacterial Agents; DNA Gyrase; DNA Topoisomerase IV; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Pyrrolidines; Topoisomerase II Inhibitors

2019
Development and characterization of a WEHI-3B D+ monomyelocytic leukemia cell line resistant to novobiocin and cross-resistant to other topoisomerase II-targeted drugs.
    Cancer research, 1992, May-15, Volume: 52, Issue:10

    Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Cell Cycle; DNA Topoisomerases, Type II; DNA, Neoplasm; Drug Resistance; Etoposide; Leukemia, Experimental; Leukemia, Myelomonocytic, Acute; Mice; Novobiocin; Topoisomerase II Inhibitors; Tritium; Tumor Cells, Cultured

1992
The effect of topoisomerase inhibitors on the expression of differentiation markers and cell cycle progression in human K-562 leukemia cells.
    Experimental cell research, 1992, Volume: 203, Issue:1

    Topics: Amsacrine; Aphidicolin; Cell Cycle; Cell Differentiation; Cycloheximide; Deoxyadenosines; Dose-Response Relationship, Drug; Etoposide; G2 Phase; Hemoglobins; Humans; Kinetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Melanins; Mitosis; Novobiocin; Teniposide; Topoisomerase II Inhibitors; Tumor Cells, Cultured

1992
Novobiocin-induced accumulation of etoposide (VP-16) in WEHI-3B D+ leukemia cells.
    International journal of cancer, 1992, Dec-02, Volume: 52, Issue:6

    Topics: Animals; Biological Transport, Active; DNA Topoisomerases, Type II; Drug Interactions; Etoposide; Leukemia, Experimental; Mice; Novobiocin; Topoisomerase II Inhibitors; Tumor Cells, Cultured

1992
Potentiation by novobiocin of the cytotoxic activity of etoposide (VP-16) and teniposide (VM-26).
    International journal of cancer, 1992, Jul-09, Volume: 51, Issue:5

    Topics: Adenocarcinoma; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cell Survival; DNA; DNA Topoisomerases, Type II; Drug Synergism; Etoposide; Humans; Leukemia; Lung Neoplasms; Novobiocin; RNA; Teniposide; Topoisomerase II Inhibitors; Tumor Cells, Cultured

1992
Differentiation of human promonocytic leukemia U-937 cells with DNA topoisomerase II inhibitors: induction of vimentin gene expression.
    Molecular pharmacology, 1991, Volume: 39, Issue:4

    Topics: Amsacrine; Antigens, Differentiation; Cell Differentiation; Cell Division; Etoposide; Gene Expression Regulation, Leukemic; Humans; Leukemia, Monocytic, Acute; Novobiocin; Oxygen; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Vimentin

1991
Novobiocin inhibits the repair of potentially lethal damage but not the repair of sublethal damage.
    Radiation research, 1990, Volume: 123, Issue:1

    Topics: Amsacrine; Animals; Cell Line; Cricetinae; DNA Damage; DNA Repair; Etoposide; Novobiocin; Teniposide; Topoisomerase II Inhibitors

1990
Effect of topoisomerase modulators on cisplatin cytotoxicity in human ovarian carcinoma cells.
    European journal of cancer (Oxford, England : 1990), 1990, Volume: 26, Issue:6

    Topics: Antibiotics, Antineoplastic; Camptothecin; Cell Line; Cisplatin; DNA Topoisomerases, Type I; Drug Interactions; Etoposide; Female; Humans; Naphthoquinones; Novobiocin; Ovarian Neoplasms; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured

1990
Comparative effects of growth inhibitors on DNA replication, DNA repair, and protein synthesis in human epidermal keratinocytes.
    Cancer research, 1986, Volume: 46, Issue:6

    Topics: Anthralin; Aphidicolin; Cells, Cultured; Diterpenes; DNA Repair; DNA Replication; Etoposide; Growth Inhibitors; Humans; Keratins; Molecular Weight; Nalidixic Acid; Novobiocin; Protein Biosynthesis; Skin; Skin Diseases; Topoisomerase II Inhibitors

1986
Novobiocin, nalidixic acid, etoposide, and 4'-(9-acridinylamino)methanesulfon-m-anisidide effects on G2 and mitotic Chinese hamster ovary cell progression.
    Cancer research, 1989, Sep-01, Volume: 49, Issue:17

    Topics: Amsacrine; Animals; Cell Line; Cell Survival; DNA Damage; Etoposide; Interphase; Metaphase; Mitosis; Nalidixic Acid; Novobiocin; RNA; Topoisomerase II Inhibitors

1989
Topoisomerase II: a potential target for novel antifungal agents.
    Biochemical and biophysical research communications, 1989, Apr-14, Volume: 160, Issue:1

    Topics: Amiloride; Amsacrine; Antifungal Agents; DNA, Superhelical; Etoposide; Molecular Structure; Novobiocin; Plasmids; Podophyllotoxin; Saccharomyces cerevisiae; Structure-Activity Relationship; Topoisomerase II Inhibitors

1989
Ciprofloxacin and etoposide (VP16) produce a similar pattern of DNA cleavage in a plasmid of an archaebacterium.
    Biochemistry, 1989, May-02, Volume: 28, Issue:9

    Topics: Ciprofloxacin; DNA Damage; Etoposide; Halobacterium; Novobiocin; Plasmids

1989
Action of etoposide (VP-16-123) on human cells: no evidence for topoisomerase II involvement in excision repair of u.v.-induced DNA damage, nor for mitochondrial hypersensitivity in ataxia telangiectasia.
    Carcinogenesis, 1987, Volume: 8, Issue:11

    Topics: Ataxia Telangiectasia; Cell Survival; Cells, Cultured; Chromosomes; DNA; DNA Damage; DNA Repair; DNA Topoisomerases, Type II; Etoposide; Humans; Mitochondria; Novobiocin; Ultraviolet Rays

1987
Topoisomerase inhibitors induce irreversible fragmentation of replicated DNA in concanavalin A stimulated splenocytes.
    Biochemistry, 1988, Jan-12, Volume: 27, Issue:1

    Topics: Animals; Camptothecin; Concanavalin A; DNA; DNA Replication; DNA Topoisomerases, Type II; Etoposide; Lymphocyte Activation; Lymphocytes; Mice; Mice, Inbred C57BL; Novobiocin; Phenylmethylsulfonyl Fluoride; Spleen; Sulfones; Topoisomerase II Inhibitors

1988
Topoisomerase-II-mediated lesions in nascent DNA: comparison of the effects of epipodophyllotoxin derivatives, VM-26 and VP-16, and 9-anilinoacridine derivatives, m-AMSA and o-AMSA.
    Biochimica et biophysica acta, 1988, May-06, Volume: 950, Issue:1

    Topics: Adenosine Triphosphate; Amsacrine; Animals; Cross-Linking Reagents; DNA; DNA Damage; DNA Replication; DNA Topoisomerases, Type II; DNA, Neoplasm; Etoposide; Leukemia L1210; Mice; Novobiocin; Podophyllotoxin; Teniposide; Topoisomerase II Inhibitors

1988
Inhibitors of DNA topoisomerase II induce topological changes in an archaebacterial plasmid in vivo.
    Biochemical pharmacology, 1988, May-01, Volume: 37, Issue:9

    Topics: Archaea; Bacteria; DNA, Bacterial; DNA, Superhelical; Etoposide; Novobiocin; Nucleic Acid Conformation; Plasmids; Topoisomerase II Inhibitors

1988
Identification of DNA topoisomerase II as an intracellular target of antitumor epipodophyllotoxins in simian virus 40-infected monkey cells.
    Cancer research, 1985, Volume: 45, Issue:11 Pt 2

    Topics: Animals; Cells, Cultured; Chemical Precipitation; DNA Topoisomerases, Type II; DNA, Viral; Etoposide; Haplorhini; Novobiocin; Podophyllotoxin; Simian virus 40; Teniposide

1985
5,6-Dichloro-1-beta-O-ribofuranosylbenzimidazole induces DNA damage by interfering with DNA topoisomerase II.
    European journal of biochemistry, 1987, May-04, Volume: 164, Issue:3

    Topics: Aphidicolin; Cells, Cultured; Chemical Precipitation; Dichlororibofuranosylbenzimidazole; Diterpenes; DNA; Electrophoresis, Agar Gel; Etoposide; Humans; Novobiocin; Proteins; Ribonucleosides; Teniposide; Topoisomerase II Inhibitors

1987
Inhibitors of topoisomerase II prevent cytokine-induced expression of vascular cell adhesion molecule-1, while augmenting the expression of endothelial leukocyte adhesion molecule-1 on human umbilical vein endothelial cells.
    Cell adhesion and communication, 1993, Volume: 1, Issue:2

    Topics: Base Sequence; Cell Adhesion Molecules; Cells, Cultured; DNA; E-Selectin; Endothelium, Vascular; Etoposide; Gene Expression Regulation; Humans; Molecular Sequence Data; Nalidixic Acid; Novobiocin; Protein Biosynthesis; Protein Kinase C; RNA, Messenger; Topoisomerase II Inhibitors; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1

1993
Increased rate of adenosine triphosphate-dependent etoposide (VP-16) efflux in a murine leukemia cell line overexpressing the multidrug resistance-associated protein (MRP) gene.
    Cancer research, 1995, Oct-01, Volume: 55, Issue:19

    Topics: Adenosine Triphosphate; Antineoplastic Agents, Phytogenic; Base Sequence; Biological Transport; DNA Topoisomerases, Type II; Drug Resistance, Multiple; Etoposide; Immunoblotting; Leukemia, Experimental; Molecular Sequence Data; Novobiocin; Nuclear Matrix; Tumor Cells, Cultured

1995
CP-115,953 stimulates cytokine production by lymphocytes.
    Antimicrobial agents and chemotherapy, 1995, Volume: 39, Issue:2

    Topics: Anti-Infective Agents; Cells, Cultured; Cytokines; DNA Damage; Etoposide; Fluoroquinolones; Humans; Interferon-gamma; Interleukin-2; Lymphocyte Activation; Novobiocin; Quinolones; RNA, Messenger; T-Lymphocytes; Thymidine; Topoisomerase II Inhibitors

1995
Antifolates can potentiate topoisomerase II inhibitors in vitro and in vivo.
    Cancer chemotherapy and pharmacology, 1995, Volume: 36, Issue:2

    Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Division; Cell Line; Cell Survival; DNA Damage; DNA, Neoplasm; Drug Synergism; Etoposide; Folic Acid Antagonists; Head and Neck Neoplasms; Humans; Male; Methotrexate; Mice; Mice, Inbred C3H; Novobiocin; Ornithine; Pterins; Topoisomerase II Inhibitors; Trimetrexate; Tumor Cells, Cultured

1995
Active dissociation of Hoechst 33342 from DNA in living mammalian cells.
    Mutation research, 1995, Volume: 327, Issue:1-2

    Topics: Benzimidazoles; DNA; Ellipticines; Etoposide; Fluorescence; HeLa Cells; Humans; Novobiocin; Topoisomerase II Inhibitors

1995
Reversal of etoposide resistance in non-P-glycoprotein expressing multidrug resistant tumor cell lines by novobiocin.
    Cancer research, 1993, Nov-15, Volume: 53, Issue:22

    Topics: Adenocarcinoma; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Colonic Neoplasms; DNA Topoisomerases, Type II; DNA, Neoplasm; Drug Resistance; Etoposide; Flow Cytometry; Humans; Leukemia L1210; Lung Neoplasms; Membrane Glycoproteins; Mice; Novobiocin; Tumor Cells, Cultured

1993
Phorbol ester induces apoptosis in HL-60 promyelocytic leukemia cells but not in HL-60 PET mutant.
    Leukemia, 1993, Volume: 7, Issue:11

    Topics: Apoptosis; Calcimycin; DNA Damage; DNA, Neoplasm; Drug Tolerance; Etoposide; Humans; Leukemia, Promyelocytic, Acute; Mutation; Novobiocin; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1993
Effects of topoisomerase II-targeted drugs on enzyme-mediated DNA cleavage and ATP hydrolysis: evidence for distinct drug interaction domains on topoisomerase II.
    Biochemistry, 1993, Apr-13, Volume: 32, Issue:14

    Topics: Adenosine Triphosphate; Amsacrine; Animals; Anti-Infective Agents; Antineoplastic Agents; Binding Sites; Cell Nucleus; DNA Topoisomerases, Type II; DNA, Bacterial; Drosophila melanogaster; Escherichia coli; Etoposide; Fluoroquinolones; Genistein; Hydrolysis; Isoflavones; Novobiocin; Plasmids; Quercetin; Quinolones; Topoisomerase II Inhibitors

1993
Exploiting mechanistic differences between drug classes to define functional drug interaction domains on topoisomerase II. Evidence that several diverse DNA cleavage-enhancing agents share a common site of action on the enzyme.
    The Journal of biological chemistry, 1993, Jul-05, Volume: 268, Issue:19

    Topics: Amsacrine; Animals; Anti-Infective Agents; Binding Sites; Cell Line; Cell Nucleus; DNA; DNA Topoisomerases, Type II; DNA, Superhelical; Drosophila melanogaster; Drug Interactions; Etoposide; Fluoroquinolones; Genistein; Growth Inhibitors; Isoflavones; Kinetics; Novobiocin; Protein Binding; Quinolones; Structure-Activity Relationship; Topoisomerase II Inhibitors

1993
Genistein induces apoptosis in immature human thymocytes by inhibiting topoisomerase-II.
    Biochemical and biophysical research communications, 1993, Jul-30, Volume: 194, Issue:2

    Topics: Apoptosis; Benzoquinones; Cells, Cultured; Chromatin; DNA Damage; Etoposide; Genistein; Humans; Immunophenotyping; Infant; Isoflavones; Kinetics; Lactams, Macrocyclic; Methylprednisolone; Novobiocin; Phorbol 12,13-Dibutyrate; Protein-Tyrosine Kinases; Quinones; Rifabutin; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thymus Gland; Time Factors; Topoisomerase II Inhibitors

1993
Method for quantifying expression of functionally active topoisomerase II in patients with leukaemia.
    Journal of clinical pathology, 1996, Volume: 49, Issue:10

    Topics: Adolescent; Adult; Aged; Animals; Biochemistry; Blastomeres; Crithidia fasciculata; DNA Topoisomerases, Type II; DNA, Kinetoplast; Doxorubicin; Ellipticines; Ethylmaleimide; Etoposide; Female; Humans; Male; Middle Aged; Novobiocin; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Sensitivity and Specificity; Topoisomerase II Inhibitors

1996
Inhibition of DNA unwinding and ATPase activities of human DNA helicase II by chemotherapeutic agents.
    Biochemical and biophysical research communications, 1997, Jul-30, Volume: 236, Issue:3

    Topics: Adenosine Triphosphatases; Amsacrine; Antineoplastic Agents; Aphidicolin; Camptothecin; Dactinomycin; Daunorubicin; DNA; DNA Helicases; Ellipticines; Enzyme Inhibitors; Ethidium; Etoposide; Genistein; Humans; Isoflavones; Nogalamycin; Novobiocin; Topoisomerase I Inhibitors

1997
Inhibition of pea chloroplast DNA helicase unwinding and ATPase activities by DNA-interacting ligands.
    Biochemical and biophysical research communications, 1998, Mar-27, Volume: 244, Issue:3

    Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Amsacrine; Camptothecin; Chloroplasts; Dactinomycin; Daunorubicin; DNA Helicases; Ellipticines; Ethidium; Etoposide; Genistein; Hydrolysis; Intercalating Agents; Ligands; Nogalamycin; Novobiocin; Pisum sativum

1998
Novobiocin-induced VP-16 accumulation and MRP expression in human leukemia and ovarian carcinoma cells.
    Anti-cancer drug design, 2000, Volume: 15, Issue:2

    Topics: Ascites; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Transport; Bone Marrow; Etoposide; Female; Humans; Kinetics; Leukemia; Multidrug Resistance-Associated Proteins; Novobiocin; Ovarian Neoplasms; Tumor Cells, Cultured

2000
Structure-activity studies of novobiocin analogs as modulators of the cytotoxicity of etoposide (VP-16).
    Oncology research, 2000, Volume: 12, Issue:3

    Topics: Adenosine Triphosphate; Antineoplastic Agents, Phytogenic; ATP-Binding Cassette Transporters; Drug Synergism; Enzyme Inhibitors; Etoposide; Humans; Multidrug Resistance-Associated Proteins; Novobiocin; Structure-Activity Relationship; Topoisomerase II Inhibitors; Tumor Cells, Cultured

2000
The effect of topoisomerase II inhibitors on the kinetoplast ultrastructure.
    Parasitology research, 2004, Volume: 94, Issue:6

    Topics: Animals; DNA Replication; DNA Topoisomerases, Type II; DNA, Kinetoplast; Enzyme Inhibitors; Etoposide; Nalidixic Acid; Novobiocin; Parasitic Sensitivity Tests; Topoisomerase II Inhibitors; Trypanocidal Agents; Trypanosomatina

2004
Transcriptional responses of Bacillus subtillis and thuringiensis to antibiotics and anti-tumour drugs.
    International journal of molecular medicine, 2009, Volume: 23, Issue:1

    Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Bacillus subtilis; Bacillus thuringiensis; Ciprofloxacin; DNA; DNA Gyrase; Etoposide; Gene Expression Regulation; Novobiocin; Plasmids; SOS Response, Genetics; Transcription, Genetic

2009
Inhibition of unwinding and ATPase activities of pea MCM6 DNA helicase by actinomycin and nogalamycin.
    Plant signaling & behavior, 2011, Volume: 6, Issue:3

    Topics: Adenosine Triphosphatases; Camptothecin; Cisplatin; Dactinomycin; Daunorubicin; DNA Helicases; Ellipticines; Enzyme Inhibitors; Etoposide; Intercalating Agents; Mitoxantrone; Nogalamycin; Novobiocin; Pisum sativum; Plant Proteins

2011