Compounds > etoposide
Page last updated: 2024-08-23

etoposide and merbarone

etoposide has been researched along with merbarone in 20 studies

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (40.00)18.2507
2000's7 (35.00)29.6817
2010's4 (20.00)24.3611
2020's1 (5.00)2.80

Authors

AuthorsStudies
Amesty, Á; Anaissi-Afonso, L; Estévez-Braun, A; Hueso-Falcón, I; Lorenzo-Castrillejo, I; Machín, F1
Arencibia, JM; Borgogno, M; De Vivo, M; Greco, ML; Minarini, A; Minniti, E; Ortega, JA; Riccardi, L; Sissi, C1
Arencibia, JM; Armirotti, A; Bertorelli, R; Bertozzi, SM; Brindani, N; De Vivo, M; Franco-Ulloa, S; Girotto, S; Kuriappan, JA; Nigro, M; Ottonello, G; Summa, M1
Berney, JJ; Chresta, CM; Delgado, C; Francis, GE; Patel, P; Tejedor, MC1
Allan, WP; Fattman, CL; Hasinoff, BB; Yalowich, JC1
Anderson, H; Roberge, M1
Levac, P; Moss, T1
Kallio, M; Lähdetie, J1
Allan, WP; Creighton, AM; Fattman, CL; Hasinoff, BB; Kuschak, TI; Thampatty, P; Yalowich, JC1
Beck, WT; Mo, YY1
Falck, J; Jensen, LH; Jensen, PB; Nitiss, JL; Roerth, M; Rose, A; Sehested, M; Wessel, I1
Berger, NA; Chatterjee, S; Gosky, D; Hirota, H1
Adler, ID; Attia, SM; Badary, OA; Hamada, FM; Schmid, TE1
Adler, ID; Attia, SM; Badary, OA; Hamada, FM; Kliesch, U; Schriever-Schwemmer, G1
Beljin, M; Clifford, B; Stark, GR; Taylor, WR1
Hagan, CR; Rudin, CM1
Eastmond, DA; Roy, SK; Wang, L1
Hirohashi, S; Honda, K; Huang, L; Ono, M; Satow, R; Shitashige, M; Tomida, A; Tsuruo, T; Yamada, T; Yun, J1
Attia, SM1
Ahmed, SM; Dröge, P1

Other Studies

20 other study(ies) available for etoposide and merbarone

ArticleYear
Synthesis and biological evaluation of naphthoquinone-coumarin conjugates as topoisomerase II inhibitors.
    Bioorganic & medicinal chemistry letters, 2017, 02-01, Volume: 27, Issue:3

    Topics: Coumarins; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Humans; Molecular Structure; Naphthoquinones; Structure-Activity Relationship; Topoisomerase II Inhibitors

2017
Pharmacophore Hybridization To Discover Novel Topoisomerase II Poisons with Promising Antiproliferative Activity.
    Journal of medicinal chemistry, 2018, 02-08, Volume: 61, Issue:3

    Topics: Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases, Type II; Drug Design; Humans; Molecular Docking Simulation; Protein Conformation; Topoisomerase II Inhibitors

2018
Design, Synthesis, Dynamic Docking, Biochemical Characterization, and
    Journal of medicinal chemistry, 2020, 04-09, Volume: 63, Issue:7

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases, Type II; Drug Design; Drug Screening Assays, Antitumor; Humans; Mice; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Poly-ADP-Ribose Binding Proteins; Protein Binding; Structure-Activity Relationship; Topoisomerase II Inhibitors

2020
Effects of DNA topoisomerase II inhibitors on human bone marrow progenitor cells.
    Leukemia, 1994, Volume: 8, Issue:1

    Topics: Adult; Alkenes; Amsacrine; Antibiotics, Antineoplastic; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Colony-Forming Units Assay; Drug Screening Assays, Antitumor; Etoposide; Hematopoietic Stem Cells; Humans; Polyenes; Pyrones; Thiobarbiturates; Topoisomerase II Inhibitors

1994
Collateral sensitivity to the bisdioxopiperazine dexrazoxane (ICRF-187) in etoposide (VP-16)-resistant human leukemia K562 cells.
    Biochemical pharmacology, 1996, Aug-23, Volume: 52, Issue:4

    Topics: Alkenes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Etoposide; Humans; Leukemia; Polyenes; Pyrones; Razoxane; Thiobarbiturates

1996
Topoisomerase II inhibitors affect entry into mitosis and chromosome condensation in BHK cells.
    Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 1996, Volume: 7, Issue:1

    Topics: Aclarubicin; Alkenes; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Cell Cycle Proteins; Cell Line; Chromosomes; Cricetinae; DNA-Binding Proteins; Enzyme Inhibitors; Etoposide; G2 Phase; Guanine Nucleotide Exchange Factors; Kidney; Mitosis; Nuclear Proteins; Okadaic Acid; Phosphoprotein Phosphatases; Polyenes; Pyrones; Razoxane; Temperature; Thiobarbiturates; Topoisomerase II Inhibitors

1996
Inactivation of topoisomerase I or II may lead to recombination or to aberrant replication termination on both SV40 and yeast 2 micron DNA.
    Chromosoma, 1996, Volume: 105, Issue:4

    Topics: Camptothecin; DNA Replication; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA, Circular; DNA, Fungal; DNA, Viral; Electrophoresis, Gel, Two-Dimensional; Enzyme Activation; Enzyme Inhibitors; Etoposide; Hypertonic Solutions; Mutation; Plasmids; Recombination, Genetic; Simian virus 40; Teniposide; Thiobarbiturates; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Yeasts

1996
Effects of the DNA topoisomerase II inhibitor merbarone in male mouse meiotic divisions in vivo: cell cycle arrest and induction of aneuploidy.
    Environmental and molecular mutagenesis, 1997, Volume: 29, Issue:1

    Topics: Aneuploidy; Animals; Antineoplastic Agents; Cell Cycle; Chromosome Aberrations; Chromosome Banding; CREST Syndrome; Enzyme Inhibitors; Etoposide; Immunohistochemistry; Kinetochores; Male; Meiosis; Mice; Mice, Inbred BALB C; Micronucleus Tests; Mitosis; Seminiferous Tubules; Spermatids; Spermatozoa; Staining and Labeling; Thiobarbiturates; Topoisomerase II Inhibitors

1997
Characterization of a Chinese hamster ovary cell line with acquired resistance to the bisdioxopiperazine dexrazoxane (ICRF-187) catalytic inhibitor of topoisomerase II.
    Biochemical pharmacology, 1997, Jun-15, Volume: 53, Issue:12

    Topics: Aclarubicin; Animals; CHO Cells; Cricetinae; DNA Topoisomerases, Type II; Drug Resistance; Ethylenediamines; Etoposide; Glycine; Mutation; Razoxane; Thiobarbiturates; Topoisomerase II Inhibitors; Verapamil

1997
DNA damage signals induction of fas ligand in tumor cells.
    Molecular pharmacology, 1999, Volume: 55, Issue:2

    Topics: Animals; Antineoplastic Agents; Apoptosis; CHO Cells; Cricetinae; DNA; DNA Damage; Doxorubicin; Enzyme Inhibitors; Etoposide; Fas Ligand Protein; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Jurkat Cells; Membrane Glycoproteins; Nucleic Acid Synthesis Inhibitors; Promoter Regions, Genetic; Razoxane; Recombinant Fusion Proteins; Signal Transduction; Teniposide; Thiobarbiturates; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Up-Regulation

1999
Human small cell lung cancer NYH cells selected for resistance to the bisdioxopiperazine topoisomerase II catalytic inhibitor ICRF-187 demonstrate a functional R162Q mutation in the Walker A consensus ATP binding domain of the alpha isoform.
    Cancer research, 1999, Jul-15, Volume: 59, Issue:14

    Topics: Adenosine Triphosphate; Amino Acid Sequence; Amino Acid Substitution; Amsacrine; Animals; Antineoplastic Agents; Binding Sites; Carcinoma, Small Cell; Catalysis; CHO Cells; Consensus Sequence; Cricetinae; Cricetulus; DNA Damage; DNA Mutational Analysis; DNA Topoisomerases, Type II; DNA, Neoplasm; DNA, Single-Stranded; Drug Resistance, Neoplasm; Enzyme Inhibitors; Etoposide; Humans; Lung Neoplasms; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Protein Isoforms; Razoxane; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Structure-Activity Relationship; Thiobarbiturates; Topoisomerase II Inhibitors; Tumor Stem Cell Assay

1999
Interference with topoisomerase IIalpha potentiates melphalan cytotoxicity.
    International journal of oncology, 2002, Volume: 20, Issue:2

    Topics: Animals; Antigens, Neoplasm; Antineoplastic Agents, Alkylating; Blotting, Western; Cell Survival; CHO Cells; Chromosomes; Cricetinae; DNA Damage; DNA Topoisomerases, Type II; DNA-Binding Proteins; Etoposide; Humans; Melphalan; Mutation; Razoxane; Sister Chromatid Exchange; Thiobarbiturates; Time Factors; Topoisomerase II Inhibitors; Tumor Cells, Cultured

2002
Molecular cytogenetic analysis in mouse sperm of chemically induced aneuploidy: studies with topoisomerase II inhibitors.
    Mutation research, 2002, Sep-26, Volume: 520, Issue:1-2

    Topics: Aneuploidy; Animals; Antineoplastic Agents, Phytogenic; Bromodeoxyuridine; Chromosome Aberrations; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epididymis; Etoposide; Image Processing, Computer-Assisted; In Situ Hybridization, Fluorescence; Male; Meiosis; Mice; Mice, Inbred C3H; Microscopy, Fluorescence; Spermatocytes; Thiobarbiturates; Topoisomerase II Inhibitors

2002
Etoposide and merbarone are clastogenic and aneugenic in the mouse bone marrow micronucleus test complemented by fluorescence in situ hybridization with the mouse minor satellite DNA probe.
    Environmental and molecular mutagenesis, 2003, Volume: 41, Issue:2

    Topics: Aneugens; Aneuploidy; Animals; Antibiotics, Antineoplastic; Bone Marrow; Chromosomes; Colchicine; DNA Probes; DNA, Satellite; Enzyme Inhibitors; Erythrocytes; Etoposide; Gout Suppressants; In Situ Hybridization, Fluorescence; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C3H; Micronucleus Tests; Mitomycin; Mutagens; Thiobarbiturates; Topoisomerase II Inhibitors

2003
G2 arrest in response to topoisomerase II inhibitors: the role of p53.
    Cancer research, 2003, Jul-15, Volume: 63, Issue:14

    Topics: Caffeine; CDC2 Protein Kinase; Cyclin B; Cyclin B1; Down-Regulation; Drug Interactions; Enzyme Inhibitors; Etoposide; Fibrosarcoma; G2 Phase; Humans; Mitosis; Thiobarbiturates; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2003
DNA cleavage and Trp53 differentially affect SINE transcription.
    Genes, chromosomes & cancer, 2007, Volume: 46, Issue:3

    Topics: Antineoplastic Agents; Cisplatin; DNA Cleavage; DNA Damage; Etoposide; Genomic Instability; Humans; Paclitaxel; Short Interspersed Nucleotide Elements; Thiobarbiturates; Topoisomerase II Inhibitors; Transcription, Genetic; Tumor Suppressor Protein p53; Up-Regulation; Vincristine

2007
Differential cell cycle-specificity for chromosomal damage induced by merbarone and etoposide in V79 cells.
    Mutation research, 2007, Mar-01, Volume: 616, Issue:1-2

    Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Cycle; Cell Line; Chromosome Aberrations; Cricetinae; Cricetulus; Enzyme Inhibitors; Etoposide; Micronuclei, Chromosome-Defective; Micronucleus Tests; Thiobarbiturates; Time Factors; Topoisomerase II Inhibitors

2007
Functional interaction of DNA topoisomerase IIalpha with the beta-catenin and T-cell factor-4 complex.
    Gastroenterology, 2007, Volume: 133, Issue:5

    Topics: Adenoma; Antigens, Neoplasm; beta Catenin; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; DNA Topoisomerases, Type II; DNA-Binding Proteins; Enzyme Inhibitors; Etoposide; Gene Expression Regulation, Neoplastic; Humans; RNA, Small Interfering; Signal Transduction; TCF Transcription Factors; Thiobarbiturates; Topoisomerase II Inhibitors; Transcription Factor 7-Like 2 Protein; Wnt Proteins

2007
Dominant lethal mutations of topoisomerase II inhibitors etoposide and merbarone in male mice: a mechanistic study.
    Archives of toxicology, 2012, Volume: 86, Issue:5

    Topics: Acetylcysteine; Animals; Dose-Response Relationship, Drug; Etoposide; Female; Fluoresceins; Male; Mice; Mutagenicity Tests; Mutagens; Mutation; Oxidative Stress; Reactive Oxygen Species; Spermatids; Thiobarbiturates; Topoisomerase II Inhibitors

2012
Oncofetal HMGA2 attenuates genotoxic damage induced by topoisomerase II target compounds through the regulation of local DNA topology.
    Molecular oncology, 2019, Volume: 13, Issue:10

    Topics: Cell Line, Tumor; DNA; DNA Damage; DNA Topoisomerases, Type II; Etoposide; HMGA2 Protein; Humans; Nucleic Acid Conformation; Poly-ADP-Ribose Binding Proteins; Thiobarbiturates; Topoisomerase II Inhibitors

2019