etoposide has been researched along with colchicine in 86 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (5.81) | 18.7374 |
| 1990's | 20 (23.26) | 18.2507 |
| 2000's | 31 (36.05) | 29.6817 |
| 2010's | 28 (32.56) | 24.3611 |
| 2020's | 2 (2.33) | 2.80 |
| Authors | Studies |
|---|---|
| Hansch, C; Khwaja, TA; Selassie, CD | 1 |
| Jurd, L; Narayanan, VL; Paull, KD | 1 |
| Barrows, LR; Ireland, CM; Kokoshka, JM | 1 |
| Cole, SP; Deeley, RG; Grant, CE; Hipfner, DR; Loe, DW; Stride, BD | 1 |
| Bastow, KF; Brossi, A; Guan, J; Hamel, E; Lee, KH; Tachibana, Y; Zhu, XK | 1 |
| Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA | 1 |
| Fischer, H; Huwyler, J; Poli, S; Schwab, D; Tabatabaei, A | 1 |
| Thakker, DR; Troutman, MD | 1 |
| Bacsó, Z; Cianfriglia, M; Fenyvesi, F; Goda, K; Kappelmayer, J; Lustyik, G; Nagy, H; Szabó, G; Szilasi, M | 1 |
| Lee, KH | 2 |
| Li, Y; Li, YH; Wang, YH; Yang, L; Yang, SL | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Artico, M; Brancale, A; Coluccia, A; De Martino, G; Díaz, JF; Edler, MC; Hamel, E; Kandil, S; La Regina, G; Lavecchia, A; Matesanz, R; Novellino, E; Piscitelli, F; Prosperi, E; Scovassi, AI; Silvestri, R | 1 |
| Bednarski, PJ; Gastpar, R; Kaufmann, D; Nishino, T; Pojarová, M; Reszka, P; von Angerer, E | 1 |
| Kornienko, A; Magedov, IV; Manpadi, M; Przheval'skii, NM; Rogelj, S; Rozhkova, E; Slambrouck, SV; Steelant, WF | 1 |
| Cook, JM; Deveau, AM; Dieckhaus, CM; Jain, HD; Johnson, MA; Kakeya, H; Liao, X; Liu, X; Ma, J; Macdonald, TL; Osada, H; Smith, KS; Zhang, C; Zhou, H; Zhou, S | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Bednarski, PJ; Kaufmann, D; Kühne, S; Müller, C; Pfaller, T; Pojarová, M; Vogel, S; von Angerer, E | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Chang, CY; Chang, JY; Chiang, YK; Coumar, MS; Hsieh, HP; Kuo, CC; Lai, MJ; Liou, JP; Reddy, GR; Tan, UK; Wu, SY; Yeh, JY | 1 |
| Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ghosh, I; Manoharlal, R; Prakash, O; Prasad, R; Puri, N; Sharma, M | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Chen, X; Lin, X; Skolnik, S; Wang, J | 1 |
| Chang, CY; Chang, JY; Kuo, CC; Lai, WY; Lee, HY; Liou, JP; Nien, CY; Shih, KH; Wu, CH | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Andricopulo, AD; Beraldo, H; Da Silva, JG; Daghestani, H; Day, BW; Dos Santos, RG; Lessa, JA; Mendes, IC; Pesquero, JL; Rocha, WR; Salum, LB; Soares, MA; Vogt, A | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chang, CY; Chang, JY; Chang, YT; Kuo, CC; Lai, MJ; Lee, HY; Liou, JP; Liu, YM; Mehndiratta, S; Nien, CY; Pan, SL; Su, MC; Wu, JS; Wu, SY | 1 |
| Chang, CY; Chang, JY; Chuang, HY; Kuo, CC; Lee, HY; Liou, JP; Yeh, TK | 1 |
| Chang, CY; Chang, JY; Chen, MC; Chiang, YF; Kuo, CC; Lai, MJ; Lee, HY; Liou, JP; Mehndiratta, S | 1 |
| Chang, CY; Chang, JY; Chuang, HY; Kuo, CC; Lai, MJ; Lee, HY; Liou, JP | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Han, HW; Hu, C; Lu, GH; Qi, JL; Qiu, HY; Sun, WX; Wang, XM; Yang, RW; Yang, YH | 1 |
| Chen, SW; Feng, SL; Guan, XW; Hui, L; Ma, YZ; Xu, XH | 1 |
| Han, HW; Ji, YJ; Lin, HY; Lu, GH; Qi, JL; Sun, WX; Wan, Y; Wang, XM; Yang, YH | 1 |
| He, L; Tang, YJ; Xiang, TL; Zhao, W | 1 |
| Bai, X; Chen, H; De Brabander, JK; Kim, J; Liou, J; McFadden, DG; Posner, B; Povedano, JM; Rallabandi, R; Rice, L; Xie, Y; Ye, X | 1 |
| Grieder, A; Maurer, R; Stähelin, H | 1 |
| Botkin, C; Knutsen, T; Sieber, SM; Whang-Peng, J | 1 |
| Dartsch, PC; Hombach, V; Kochs, M; Osterhues, H; Roth, D; Seitzer, U; Voisard, R | 1 |
| Cowled, PA; Forbes, IJ; Giannakis, C; Zalewski, PD | 1 |
| Chrétien, P; Huot, J; Lambert, H; Landry, J; Roy, G | 1 |
| Koch, G; Reeve, JG; Twentyman, PR; Wright, KA | 1 |
| Andreeff, M; Howell, SB; Shalinsky, DR | 1 |
| Cole, SP; Gerlach, JH; Mirski, SE | 1 |
| Yalowich, JC | 1 |
| Cardarelli, C; Gottesman, MM; Pastan, I; Stein, WD | 1 |
| Baur, R; Dartsch, PC; Höher, M; Hombach, V; Osterhues, H; Seitzer, U; Voisard, R | 1 |
| Balkenende, AY; Slaper-Cortenbach, IC; van den Berg, H; van der Schoot, CE; Van Leeuwen, EF; Vervoordeldonk, SF; von dem Borne, AE | 1 |
| Smith, CD; Zhang, X | 1 |
| Aran, JM; Gottesman, MM; Licht, T; Pastan, I | 1 |
| Flavell, RA; Lorico, A; Rappa, G; Sartorelli, AC | 1 |
| Kane, SE; Kino, K; Komano, T; Morishima, M; Taguchi, Y; Ueda, K | 1 |
| Komano, T; Morishima, M; Taguchi, Y; Ueda, K | 1 |
| Ling, V; Shapiro, AB | 1 |
| Armin, G; Axenovich, SA; Boiko, AD; Gudkov, AV; Kazarov, AR; Roninson, IB | 1 |
| Horton, JK; Reuss, L; Vanoye, CG | 1 |
| Filipeanu, CM; Klappe, K; Kok, JW; Koning, H; Müller, M; Veldman, RJ | 1 |
| Elmquist, WF; Sawchuk, RJ | 1 |
| Chen, L; Liu, Y | 1 |
| Roninson, IB; Rose, E; Ruth, A; Stein, WD | 1 |
| Akiyama, S; Aoki, S; Belinsky, MG; Chen, ZS; Furukawa, T; Kobayashi, M; Komatsu, M; Kruh, GD; Lee, K; Okumura, H; Ren, XQ; Sumizawa, T; Ueda, K | 1 |
| Baptiste, N; Chen, X; Friedlander, P; Prives, C | 1 |
| Chen, Q; Yang, Y; Zhang, JT | 1 |
| Adler, ID; Attia, SM; Badary, OA; Hamada, FM; Kliesch, U; Schriever-Schwemmer, G | 1 |
| Cardozo-Pelaez, F; Chan, SL; Chrest, FJ; Emokpae, R; Gorospe, M; Kruman, II; Mattson, MP; Smilenov, L; Wersto, RP | 1 |
| Al-Shawi, MK; Figler, RA; Omote, H; Polar, MK | 1 |
| Cerman, J; Cervinka, M; Rudolf, E | 1 |
| Coley, HM; Hughes, MP; Labeed, FH; Thomas, H | 1 |
| Batista, AA; Beraldo, H; Fagundes, ES; Graminha, AE; Rodrigues, C; Teixeira, LR | 1 |
| Fowler, P; Jeffrey, L; Kirkland, D; Smith, K; Whitwell, J; Young, J | 1 |
| Elhajouji, A | 1 |
| Chen, Y; Ding, J; Huan, XJ; Miao, ZH; Song, SS; Sun, YM; Tian, QT; Wang, W; Wang, YQ; Yang, CH; Yi, JM; Zhang, XF | 1 |
| Asaduzzaman, M; Coombes, RC; Cuella, R; Hu, Y; Li, K; Raguz, S; Shi, H; Yagüe, E; Zhou, Y | 1 |
| Daugel-Dauge, NO; Durnev, AD; Kulakova, AV; Pligina, KL; Zhanataev, AK | 1 |
| Banerjee, S; Datta, S; Jahnavi, J; Maity, TR; Samanta, A | 1 |
4 review(s) available for etoposide and colchicine
| Article | Year |
|---|---|
Current developments in the discovery and design of new drug candidates from plant natural product leads.
Topics: Anti-HIV Agents; Antineoplastic Agents; Biological Factors; Drug Design; Molecular Structure; Plants, Medicinal; Structure-Activity Relationship | 2004 |
Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach.
Topics: Anti-HIV Agents; Biological Factors; Drug Design; Molecular Structure; Pharmaceutical Preparations; Plants, Medicinal | 2010 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Microdialysis in the study of drug transporters in the CNS.
Topics: Animals; Biological Transport; Brain; Colchicine; Etoposide; Humans; Microdialysis; Morphine; Probenecid; Rhodamines; Zidovudine | 2000 |
82 other study(ies) available for etoposide and colchicine
| Article | Year |
|---|---|
Structure-activity relationships of antineoplastic agents in multidrug resistance.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Cricetinae; Dactinomycin; Drug Resistance; Leukemia L1210; Mice; Regression Analysis; Structure-Activity Relationship; Tumor Cells, Cultured | 1990 |
In vivo antitumor activity of 6-benzyl-1,3-benzodioxole derivatives against the P388, L1210, B16, and M5076 murine models.
Topics: Animals; Antineoplastic Agents; Astrocytoma; Bucladesine; Cell Differentiation; Dioxoles; DNA Topoisomerases, Type I; Leukemia L1210; Leukemia P388; Leukemia, Experimental; Mice; Tubulin | 1987 |
Cell-based screen for identification of inhibitors of tubulin polymerization.
Topics: Animals; Brain Neoplasms; Bucladesine; Cell Differentiation; Drug Screening Assays, Antitumor; Formazans; Glioma; Rats; Tubulin; Tumor Cells, Cultured | 1996 |
Pharmacological characterization of the murine and human orthologs of multidrug-resistance protein in transfected human embryonic kidney cells.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; ATP-Binding Cassette Transporters; Cells, Cultured; Culture Techniques; Drug Resistance, Neoplasm; Embryo, Mammalian; Estradiol; Glutathione; Humans; Isomerism; Kidney; Leukotriene C4; Membranes; Mice; Multidrug Resistance-Associated Proteins; Phenotype; Transfection; Vincristine | 1997 |
Antitumor agents. 185. Synthesis and biological evaluation of tridemethylthiocolchicine analogues as novel topoisomerase II inhibitors.
Topics: Antineoplastic Agents; Cell Division; Colchicine; DNA; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; KB Cells; Topoisomerase II Inhibitors; Tubulin; Tubulin Modulators; Tumor Cells, Cultured | 1998 |
Rational use of in vitro P-glycoprotein assays in drug discovery.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera | 2001 |
Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cells, Cultured; Drug Evaluation, Preclinical; Fluoresceins; Fluorescent Dyes; Humans; Indicators and Reagents; Mice; Models, Molecular; Rhodamines; Species Specificity; Swine | 2003 |
Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blotting, Western; Cells, Cultured; Diffusion; Humans; Intestinal Absorption; Intestinal Mucosa; Models, Biological; Permeability; Pharmaceutical Preparations; Pharmacokinetics | 2003 |
Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies.
Topics: Adenosine Triphosphatases; Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Calcium Channel Blockers; Cyclosporine; Detergents; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluoresceins; Humans; Ivermectin; Mice; NIH 3T3 Cells; Substrate Specificity | 2004 |
Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism.
Topics: Computational Biology; Cyclohexanols; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Molecular Structure; Principal Component Analysis; Pyrrolizidine Alkaloids; Quantitative Structure-Activity Relationship; Reproducibility of Results; Substrate Specificity; Venlafaxine Hydrochloride | 2005 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Arylthioindole inhibitors of tubulin polymerization. 3. Biological evaluation, structure-activity relationships and molecular modeling studies.
Topics: Apoptosis; Biopolymers; Cell Cycle; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Hydrogen Bonding; Indoles; Models, Molecular; Protein Binding; Radioligand Assay; Structure-Activity Relationship; Tubulin; Tubulin Modulators | 2007 |
[(2-Phenylindol-3-yl)methylene]propanedinitriles inhibit the growth of breast cancer cells by cell cycle arrest in G(2)/M phase and apoptosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Caspase Inhibitors; Cell Cycle; Cell Division; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; G2 Phase; Humans; Indoles; Mammary Neoplasms, Experimental; Mice; Molecular Structure; Nitriles; Stereoisomerism; Structure-Activity Relationship; Tubulin | 2007 |
Discovery and investigation of antiproliferative and apoptosis-inducing properties of new heterocyclic podophyllotoxin analogues accessible by a one-step multicomponent synthesis.
Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Screening Assays, Antitumor; Heterocyclic Compounds, 3-Ring; Humans; Lymphocytes; Podophyllotoxin; Pyrazoles; Stereoisomerism; Structure-Activity Relationship | 2007 |
Synthesis and structure-activity relationship studies on tryprostatin A, an inhibitor of breast cancer resistance protein.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases, Type II; Drug Resistance, Neoplasm; Enzyme Inhibitors; Humans; Indole Alkaloids; Molecular Structure; Piperazines; Structure-Activity Relationship; Topoisomerase II Inhibitors; Tubulin | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Aroyl hydrazones of 2-phenylindole-3-carbaldehydes as novel antimitotic agents.
Topics: Antimitotic Agents; Benzoates; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Humans; Hydrazones; Indoles; Pyridines | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Synthesis and structure-activity relationships of 2-amino-1-aroylnaphthalene and 2-hydroxy-1-aroylnaphthalenes as potent antitubulin agents.
Topics: Anisoles; Cell Line, Tumor; Cell Proliferation; Chemistry, Pharmaceutical; Drug Design; Drug Screening Assays, Antitumor; Humans; Indoles; Inhibitory Concentration 50; Models, Chemical; Naphthalenes; Neoplasms; Structure-Activity Relationship; Tubulin; Tubulin Modulators | 2008 |
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans.
Topics: Candida albicans; Membrane Transport Proteins; Saccharomyces cerevisiae; Structure-Activity Relationship; Substrate Specificity | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model.
Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity | 2011 |
5-Amino-2-aroylquinolines as highly potent tubulin polymerization inhibitors. Part 2. The impact of bridging groups at position C-2.
Topics: Aminoquinolines; Angiogenesis Inhibitors; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Colchicine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Human Umbilical Vein Endothelial Cells; Humans; Hydroxyquinolines; Quinolines; Stilbenes; Structure-Activity Relationship; Sulfones; Tubulin Modulators | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
N⁴-Phenyl-substituted 2-acetylpyridine thiosemicarbazones: cytotoxicity against human tumor cells, structure-activity relationship studies and investigation on the mechanism of action.
Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Death; Cell Line, Tumor; Central Nervous System Neoplasms; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Etoposide; Female; Glioblastoma; Glioma; Humans; Inhibitory Concentration 50; Microtubules; Molecular Structure; Structure-Activity Relationship; Thiosemicarbazones; Tubulin; Tumor Suppressor Protein p53 | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Furanylazaindoles: potent anticancer agents in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Female; Heterocyclic Compounds, 2-Ring; HT29 Cells; Humans; Indoles; Inhibitory Concentration 50; Mice, Nude; Molecular Structure; Neoplasms; Polymerization; Sulfonamides; Tubulin; Xenograft Model Antitumor Assays | 2013 |
Antimitotic and vascular disrupting agents: 2-hydroxy-3,4,5-trimethoxybenzophenones.
Topics: Antimitotic Agents; Benzophenones; Cell Line, Tumor; Cell Proliferation; Colchicine; Dose-Response Relationship, Drug; HT29 Cells; Human Umbilical Vein Endothelial Cells; Humans; KB Cells; Molecular Structure; Polymerization; Structure-Activity Relationship; Tubulin | 2014 |
Concise syntheses of 7-anilino-indoline-N-benzenesulfonamides as antimitotic and vascular disrupting agents.
Topics: Antineoplastic Agents; Capillaries; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HT29 Cells; Humans; Indoles; KB Cells; Mitosis; Molecular Structure; Polymerization; Structure-Activity Relationship; Sulfonamides; Tubulin; Tubulin Modulators | 2014 |
Antimitotic and antivascular activity of heteroaroyl-2-hydroxy-3,4,5-trimethoxybenzenes.
Topics: Angiogenesis Inhibitors; Antimitotic Agents; Benzene; Binding Sites; Cell Line, Tumor; Cell Proliferation; Chemistry Techniques, Synthetic; Colchicine; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; HT29 Cells; Human Umbilical Vein Endothelial Cells; Humans; Inhibitory Concentration 50; Structure-Activity Relationship; Tubulin Modulators | 2015 |
Design, synthesis and anti-cancer activity evaluation of podophyllotoxin-norcantharidin hybrid drugs.
Topics: Antineoplastic Agents; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Cell Cycle; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; HEK293 Cells; Humans; MCF-7 Cells; Molecular Structure; Podophyllotoxin; Structure-Activity Relationship | 2016 |
One-pot synthesis and biological evaluation of N-(aminosulfonyl)-4-podophyllotoxin carbamates as potential anticancer agents.
Topics: Antineoplastic Agents; Carbamates; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Podophyllotoxin; Structure-Activity Relationship | 2017 |
Design and synthesis of piperazine acetate podophyllotoxin ester derivatives targeting tubulin depolymerization as new anticancer agents.
Topics: Acetates; Antineoplastic Agents; Cell Cycle Checkpoints; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Esters; Humans; MCF-7 Cells; Molecular Structure; Piperazine; Piperazines; Podophyllotoxin; Polymerization; Structure-Activity Relationship; Tubulin | 2017 |
Discover 4β-NH-(6-aminoindole)-4-desoxy-podophyllotoxin with nanomolar-potency antitumor activity by improving the tubulin binding affinity on the basis of a potential binding site nearby colchicine domain.
Topics: Animals; Antineoplastic Agents; Binding Sites; Cell Cycle Checkpoints; Colchicine; Drug Design; Humans; Male; Mice, Inbred BALB C; Mice, Nude; Molecular Docking Simulation; Podophyllotoxin; Tubulin; Tubulin Modulators | 2019 |
A Multipronged Approach Establishes Covalent Modification of β-Tubulin as the Mode of Action of Benzamide Anti-cancer Toxins.
Topics: Antineoplastic Agents; Benzamides; Binding Sites; Colchicine; Humans; Lung Neoplasms; Microtubules; Protein Conformation; Small Cell Lung Carcinoma; Structure-Activity Relationship; Tubulin; Tubulin Modulators | 2020 |
Comparative study of early effects of epipodophyllotoxin derivatives and other cytostatic agents on mastocytoma cultures.
Topics: Antineoplastic Agents; Bleomycin; Cell Division; Cell Line; Colchicine; Cytarabine; DNA, Neoplasm; Etoposide; Mast-Cell Sarcoma; Mechlorethamine; Mercaptopurine; Methotrexate; Mitosis; Neoplasm Proteins; Neoplasms, Experimental; Podophyllotoxin; Razoxane; RNA, Neoplasm; Teniposide; Vincristine; X-Rays | 1977 |
Teratogenic and cytogenetic effects of some plant-derived antitumor agents (vincristine, colchicine, maytansine, VP-16-213 and VM-26) in mice.
Topics: Abnormalities, Drug-Induced; Animals; Antineoplastic Agents; Cells, Cultured; Chromosome Aberrations; Chromosomes; Colchicine; Etoposide; Female; Gestational Age; Maytansine; Mice; Pregnancy; Teniposide; Teratogens; Vincristine | 1978 |
[The effect of propranolol, lisinopril, prednisolone, colchicine, etoposide and vincristine on proliferation of re-stenosing human plaque cells in vitro: cell culture as a prescreening system for prevention of restenosis].
Topics: Angioplasty, Balloon; Angiotensin-Converting Enzyme Inhibitors; Arteriosclerosis; Atherectomy; Cell Division; Cells, Cultured; Colchicine; Dipeptides; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Etoposide; Humans; Lisinopril; Muscle, Smooth, Vascular; Prednisolone; Propranolol; Recurrence; Vincristine | 1992 |
Induction of apoptosis in chronic lymphocytic leukemia cells and its prevention by phorbol ester.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aurintricarboxylic Acid; Cell Death; Colchicine; DNA Damage; Electrophoresis, Agar Gel; Etoposide; Humans; Isoquinolines; Leukemia, Lymphocytic, Chronic, B-Cell; Methylprednisolone; Phorbol 12,13-Dibutyrate; Piperazines; Tumor Cells, Cultured | 1992 |
Increased survival after treatments with anticancer agents of Chinese hamster cells expressing the human Mr 27,000 heat shock protein.
Topics: Animals; Antineoplastic Agents; Arsenic; Arsenites; Blotting, Western; Carmustine; Cell Line; Cell Survival; Colchicine; Cricetinae; Dactinomycin; Daunorubicin; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Etoposide; Fluorouracil; Heat-Shock Proteins; Humans; Hydrogen Peroxide; Pentosyltransferases; Sodium Compounds; Teniposide; Vincristine | 1991 |
Chemosensitisation by verapamil and cyclosporin A in mouse tumour cells expressing different levels of P-glycoprotein and CP22 (sorcin).
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Calcium-Binding Proteins; Carcinosarcoma; Cell Line; Colchicine; Cyclosporins; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Etoposide; Gene Expression; Mammary Neoplasms, Animal; Membrane Glycoproteins; Mice; Neoplasm Proteins; Verapamil; Vincristine | 1990 |
Modulation of drug sensitivity by dipyridamole in multidrug resistant tumor cells in vitro.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Squamous Cell; Cell Survival; Colchicine; Dipyridamole; Drug Resistance; Drug Synergism; Etoposide; Humans; In Vitro Techniques; Membrane Glycoproteins; Neoplasm Proteins; Verapamil; Vinblastine | 1990 |
Multidrug resistance in a human small cell lung cancer cell line selected in adriamycin.
Topics: Animals; Antibodies, Monoclonal; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Small Cell; Cell Line; Colchicine; Daunorubicin; Doxorubicin; Drug Resistance; Enzyme-Linked Immunosorbent Assay; Epirubicin; Etoposide; Glycoproteins; Gramicidin; Humans; Immunosorbent Techniques; Isoxazoles; Lung Neoplasms; Menogaril; Mice; Mice, Inbred BALB C; Mitoxantrone; Nogalamycin; Phenotype; Vinblastine; Vincristine | 1987 |
Effects of microtubule inhibitors on etoposide accumulation and DNA damage in human K562 cells in vitro.
Topics: Alkaloids; Cell Line; Colchicine; DNA; Dose-Response Relationship, Drug; Doxorubicin; Etoposide; Humans; In Vitro Techniques; Maytansine; Microtubules; Paclitaxel; Podophyllotoxin; Time Factors; Vinblastine | 1987 |
Kinetic evidence suggesting that the multidrug transporter differentially handles influx and efflux of its substrates.
Topics: 3T3 Cells; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Carrier Proteins; Colchicine; Daunorubicin; Drug Resistance; Etoposide; Humans; Kinetics; Membrane Glycoproteins; Mice; Quinidine; Recombinant Proteins; Structure-Activity Relationship; Substrate Specificity; Vinblastine | 1994 |
A prescreening system for potential antiproliferative agents: implications for local treatment strategies of postangioplasty restenosis.
Topics: Actins; Adult; Aged; Aged, 80 and over; Angioplasty, Balloon; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Arteriosclerosis; Cell Division; Cells, Cultured; Colchicine; Cyclosporine; Dalteparin; Doxorubicin; Drug Evaluation, Preclinical; Etoposide; Female; Femoral Artery; Fibrinolytic Agents; Gout Suppressants; Humans; Immunosuppressive Agents; Male; Microtubules; Middle Aged; Muscle, Smooth, Vascular; Recurrence; Vimentin | 1995 |
Degradation of radioiodinated B cell monoclonal antibodies: inhibition via a FCgamma-receptor-II-mediated mechanism and by drugs.
Topics: Animals; Antibodies, Monoclonal; Antigens, CD; Antigens, CD19; Antigens, Differentiation, B-Lymphocyte; Antineoplastic Agents; B-Lymphocytes; Biological Transport; Burkitt Lymphoma; Calcium Channel Blockers; Cell Adhesion Molecules; Chloroquine; Colchicine; Etoposide; Humans; Immunoglobulin Isotypes; Immunotoxins; Iodine Radioisotopes; Lectins; Leukemia, B-Cell; Mice; Monensin; Paclitaxel; Radioimmunotherapy; Receptors, IgG; Sialic Acid Binding Ig-like Lectin 2; Verapamil; Vinblastine; Vincristine | 1996 |
Microtubule effects of welwistatin, a cyanobacterial indolinone that circumvents multiple drug resistance.
Topics: Alkaloids; Antineoplastic Agents; Camptothecin; Cell Cycle; Cell Division; Cell Line; Cell Survival; Colchicine; Cyanobacteria; Cytoskeleton; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA, Neoplasm; Drug Resistance, Multiple; Etoposide; Female; GTP Phosphohydrolases; Humans; Indole Alkaloids; Kinetics; Microtubules; Muscle, Smooth, Vascular; Ovarian Neoplasms; Tubulin | 1996 |
Complete restoration of glucocerebrosidase deficiency in Gaucher fibroblasts using a bicistronic MDR retrovirus and a new selection strategy.
Topics: Animals; Anthracenes; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Northern; Blotting, Western; Cells, Cultured; Colchicine; Cyclosporins; DNA, Complementary; Doxorubicin; Drug Resistance, Multiple; Etoposide; Fibroblasts; Gaucher Disease; Gene Expression Regulation; Genetic Therapy; Genetic Vectors; Glucosylceramidase; Humans; Mice; Mutagenesis, Insertional; Retroviridae; Transfection; Verapamil | 1996 |
Double knockout of the MRP gene leads to increased drug sensitivity in vitro.
Topics: Animals; Antineoplastic Agents; Arsenites; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cell Line; Colchicine; Cytarabine; Daunorubicin; Doxorubicin; Drug Resistance, Neoplasm; Etoposide; Gene Targeting; Humans; Mice; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Sodium Compounds; Stem Cells; Teniposide; Vincristine | 1996 |
Alteration of substrate specificity by mutations at the His61 position in predicted transmembrane domain 1 of human MDR1/P-glycoprotein.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Colchicine; Cystic Fibrosis Transmembrane Conductance Regulator; DNA Mutational Analysis; Doxorubicin; Drug Resistance, Neoplasm; Etoposide; Fluoresceins; Fluorescent Dyes; Histidine; Humans; Models, Molecular; Mutagenesis, Site-Directed; Protein Structure, Tertiary; Rhodamine 123; Rhodamines; Substrate Specificity; Tumor Cells, Cultured; Vinblastine | 1997 |
Amino acid substitutions in the first transmembrane domain (TM1) of P-glycoprotein that alter substrate specificity.
Topics: Alanine; Arginine; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Membrane; Cells, Cultured; Colchicine; DNA Mutational Analysis; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Etoposide; Glycine; Histidine; Humans; Immunoblotting; Isoleucine; Leucine; Substrate Specificity; Vinblastine | 1997 |
Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzimidazoles; Binding Sites; Biological Transport; Cell Line; Cell Membrane; Colchicine; Cricetinae; Cricetulus; Dactinomycin; Daunorubicin; Doxorubicin; Etoposide; Fluorescence; Fluorescent Dyes; Kinetics; Liposomes; Protein Binding; Quercetin; Rhodamine 123; Rhodamines; Vinblastine | 1997 |
Altered expression of ubiquitous kinesin heavy chain results in resistance to etoposide and hypersensitivity to colchicine: mapping of the domain associated with drug response.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Antineoplastic Agents, Phytogenic; Chromosome Mapping; Colchicine; DNA, Complementary; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Etoposide; Fibrosarcoma; Gout Suppressants; Humans; Kinesins; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Polymerase Chain Reaction; Sequence Homology, Amino Acid; Suppression, Genetic; Transfection; Tumor Cells, Cultured | 1998 |
Swelling-activated chloride currents in a drug-sensitive cell line and a P glycoprotein-expressing derivative are underlied by channels with the same pharmacological properties.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Size; Chloride Channels; Colchicine; Cytochalasin D; Cytoskeleton; Electrophysiology; Etoposide; Humans; Hypertonic Solutions; Hypotonic Solutions; Meglumine; Nitrobenzenes; Tumor Cells, Cultured; Verapamil; Vinblastine | 1998 |
Differential expression of sphingolipids in MRP1 overexpressing HT29 cells.
Topics: Antineoplastic Agents; ATP-Binding Cassette Transporters; Cell Survival; Ceramides; Colchicine; Colonic Neoplasms; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Etoposide; Fluoresceins; Galactosylceramides; Glucosylceramides; HT29 Cells; Humans; Immunoblotting; Immunohistochemistry; Microscopy, Confocal; Microtubules; Mitosis; Multidrug Resistance-Associated Proteins; Paclitaxel; Propionates; Quinolines; Signal Transduction; Sphingolipids; Vincristine | 2000 |
[Protection of hematopoietic cells against toxicity of anticancer agents by transfecting mdr1 gene into bone marrow cells].
Topics: Animals; Antineoplastic Agents; Bone Marrow Cells; Colchicine; Disease Models, Animal; Doxorubicin; Drug Resistance, Neoplasm; Etoposide; Genes, MDR; Humans; Mice; Transfection; Vincristine | 2000 |
Coordinate changes in drug resistance and drug-induced conformational transitions in altered-function mutants of the multidrug transporter P-glycoprotein.
Topics: 3T3 Cells; Amino Acid Substitution; Animals; Antibodies, Monoclonal; Antigen-Antibody Reactions; Asparagine; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Colchicine; Drug Resistance, Multiple; Etoposide; Genetic Vectors; Glycine; Humans; Isoleucine; Mice; Mutagenesis, Site-Directed; Protein Conformation; Transduction, Genetic; Transfection; Valine; Vinblastine | 2001 |
Reversal of drug resistance mediated by multidrug resistance protein (MRP) 1 by dual effects of agosterol A on MRP1 function.
Topics: Adenosine Triphosphate; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Membrane; Cell Survival; Colchicine; Doxorubicin; Drug Resistance, Multiple; Etoposide; Gene Expression Regulation; Humans; KB Cells; Marine Toxins; Recombinant Proteins; Sterols; Vincristine | 2001 |
The proline-rich domain of p53 is required for cooperation with anti-neoplastic agents to promote apoptosis of tumor cells.
Topics: Antineoplastic Agents; Apoptosis; Camptothecin; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Clone Cells; Colchicine; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Daunorubicin; DNA Damage; DNA, Neoplasm; Etoposide; Fluorouracil; Gene Expression Regulation, Neoplastic; Genes, p53; Humans; Lung Neoplasms; Models, Biological; Proline; Promoter Regions, Genetic; Protein Structure, Tertiary; Recombinant Fusion Proteins; Structure-Activity Relationship; Tetracycline; Transcription, Genetic; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2002 |
Structural and functional consequences of mutating cysteine residues in the amino terminus of human multidrug resistance-associated protein 1.
Topics: Adenosine Triphosphate; Alanine; Amino Acid Sequence; Antineoplastic Agents; Blotting, Western; Cell Membrane; Cell Separation; Cells, Cultured; Colchicine; Cysteine; DNA Mutational Analysis; Dose-Response Relationship, Drug; Doxorubicin; Etoposide; Flow Cytometry; Fluorescent Antibody Technique, Indirect; Glycosylation; Humans; Kinetics; Leukotriene C4; Microscopy, Confocal; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Mutation; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Structure-Activity Relationship; Time Factors; Transfection; Trypsin; Vincristine | 2002 |
Etoposide and merbarone are clastogenic and aneugenic in the mouse bone marrow micronucleus test complemented by fluorescence in situ hybridization with the mouse minor satellite DNA probe.
Topics: Aneugens; Aneuploidy; Animals; Antibiotics, Antineoplastic; Bone Marrow; Chromosomes; Colchicine; DNA Probes; DNA, Satellite; Enzyme Inhibitors; Erythrocytes; Etoposide; Gout Suppressants; In Situ Hybridization, Fluorescence; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C3H; Micronucleus Tests; Mitomycin; Mutagens; Thiobarbiturates; Topoisomerase II Inhibitors | 2003 |
Cell cycle activation linked to neuronal cell death initiated by DNA damage.
Topics: Animals; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Cell Cycle; Cell Cycle Proteins; Cells, Cultured; Colchicine; DNA Damage; DNA-Binding Proteins; Etoposide; Female; Homocysteine; Male; Methotrexate; Mice; Nerve Degeneration; Neurons; Protein Serine-Threonine Kinases; Rats; Staurosporine; Tumor Suppressor Proteins | 2004 |
Improved energy coupling of human P-glycoprotein by the glycine 185 to valine mutation.
Topics: Adenosine Triphosphatases; Amino Acid Substitution; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Colchicine; Cysteine; Drug Resistance, Multiple; Electron Spin Resonance Spectroscopy; Etoposide; Glycine; History, Ancient; Humans; Membrane Lipids; Mutagenesis, Site-Directed; Saccharomyces cerevisiae Proteins; Spin Labels; Substrate Specificity; Thermodynamics; Valine | 2004 |
Apoptosis in Hep2 cells treated with etoposide and colchicine.
Topics: Apoptosis; Cell Division; Colchicine; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Therapy, Combination; Etoposide; Humans; Microscopy, Video; Reference Values; Sensitivity and Specificity; Tumor Cells, Cultured | 2004 |
Biophysical characterization of MDR breast cancer cell lines reveals the cytoplasm is critical in determining drug sensitivity.
Topics: Anthracyclines; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Breast Neoplasms; Carbocyanines; Cell Line, Tumor; Cell Survival; Cisplatin; Colchicine; Cytoplasm; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Electrophoresis; Etoposide; Female; Fluorescent Dyes; Humans; Inhibitory Concentration 50; Membrane Potentials; Membrane Transport Proteins; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Paclitaxel; Phenotype | 2007 |
Ruthenium(II) complexes of 2-benzoylpyridine-derived thiosemicarbazones with cytotoxic activity against human tumor cell lines.
Topics: Antineoplastic Agents; Benzyl Compounds; Cell Death; Cell Line, Tumor; Cell Proliferation; Colchicine; Drug Screening Assays, Antitumor; Electrochemistry; Etoposide; Humans; Magnetic Resonance Spectroscopy; Pyridines; Ruthenium; Spectrophotometry, Infrared; Thiosemicarbazones | 2008 |
Etoposide; colchicine; mitomycin C and cyclophosphamide tested in the in vitro mammalian cell micronucleus test (MNvit) in Chinese hamster lung (CHL) cells at Covance laboratories; Harrogate UK in support of OECD draft Test Guideline 487.
Topics: Animals; Cell Count; Cell Death; Cell Line; Cell Proliferation; Colchicine; Cricetinae; Cricetulus; Cyclophosphamide; Cytochalasin B; Etoposide; Guidelines as Topic; Lung; Micronucleus Tests; Mitomycin; Mutagens | 2010 |
Mitomycin C, 5-fluoruracil, colchicine and etoposide tested in the in vitro mammalian cell micronucleus test (MNvit) in the human lymphoblastoid cell line TK6 at Novartis in support of OECD draft Test Guideline 487.
Topics: Cell Count; Cell Line; Cell Proliferation; Colchicine; Cytochalasin B; Cytokinesis; Etoposide; Fluorouracil; Guidelines as Topic; Humans; Lymphocytes; Micronucleus Tests; Mitomycin; Mutagens; Switzerland | 2010 |
Dual targeting of microtubule and topoisomerase II by α-carboline derivative YCH337 for tumor proliferation and growth inhibition.
Topics: Animals; Apoptosis; Binding Sites; Binding, Competitive; Carbolines; Cell Line, Tumor; Colchicine; Colonic Neoplasms; DNA Breaks, Double-Stranded; DNA Topoisomerases, Type II; DNA, Neoplasm; DNA, Superhelical; Drug Interactions; Drug Screening Assays, Antitumor; Etoposide; Humans; Inhibitory Concentration 50; Metaphase; Mice; Mice, Nude; Microtubules; Molecular Structure; Neoplasm Proteins; Paclitaxel; Topoisomerase II Inhibitors; Tubulin; Tubulin Modulators; Vincristine | 2015 |
MiR-106b~25 cluster regulates multidrug resistance in an ABC transporter-independent manner via downregulation of EP300.
Topics: Antineoplastic Agents; Apoptosis; ATP-Binding Cassette Transporters; Breast; Cadherins; Cell Line, Transformed; Colchicine; Down-Regulation; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; E1A-Associated p300 Protein; Epithelial Cells; Etoposide; Gamma Rays; Humans; MicroRNAs; Multigene Family; Neoplasm Proteins; Paclitaxel; Phenotype; RNA, Neoplasm; Transduction, Genetic; Tumor Stem Cell Assay | 2016 |
Induced Aneugenic Effects in Mouse Oocytes In Vivo.
Topics: Aneugens; Aneuploidy; Animals; Cisplatin; Colchicine; Doxorubicin; Etoposide; Melphalan; Mice; Oocytes; Paclitaxel; Polyploidy | 2017 |
Towards establishment of a plant-based model to assess the novel anti-cancerous lead molecule(s): An in silico, in vivo and in vitro assessment of some potential anti-cancerous drugs on Lathyrus sativus L.
Topics: Colchicine; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Etoposide; Fluorouracil; Humans; Lathyrus; Methotrexate; Pemetrexed; Plant Proteins; RNA; Topotecan | 2022 |