Page last updated: 2024-08-23

etoposide and caffeine

etoposide has been researched along with caffeine in 45 studies

Research

Studies (45)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's11 (24.44)18.2507
2000's19 (42.22)29.6817
2010's15 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Lombardo, F; Obach, RS; Waters, NJ1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
Campillo, NE; Guerra, A; Páez, JA1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Avdeef, A; Tam, KY1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Glen, RC; Lowe, R; Mitchell, JB1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Ekins, S; Williams, AJ; Xu, JJ1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Baba, H; Tomita, K; Tsuchiya, H; Ueda, Y; Yasutake, H; Yokogawa, A1
Shin, CG; Snapka, RM; Strayer, JM; Wani, MA1
Clarke, DJ; Creighton, AM; Downes, CS; Giménez-Abián, JF; Johnson, RT; Mullinger, AM1
Feldhoff, RC; Galperina, OV; Lock, RB; Rhodes, LJ1
Aller, P; Pelayo, F; Pérez, C; Vilaboa, NE1
Gibbons, DL; Greaves, MF; Griffiths, SD; Kabarowski, JH; Nishii, K; Titley, I; Wiedemann, LM1
Amano, T; Hatori, S; Imada, T; Ito, H; Kondo, J; Maehara, T; Rino, Y; Shiozawa, M; Suzuki, Y; Takahashi, M1
Fukuda, M; Moriguchi, T; Nishida, E; Toyoshima, F; Wada, A1
Barratt, RA; Kao, G; Kuang, J; McKenna, WG; Muschel, RJ1
Burns, EM; Christopoulou, L; Corish, P; Tyler-Smith, C1
Bret-Bennis, L; Cans, C; De Rycke, J; Ducommun, B; Oswald, E; Sert, V; Tasca, C1
Baudouin, C; Casagrande, F; Darbon, JM; Ducommun, B; Escalas, N; Goubin-Gramatica, F; Penary, M1
Mizutani, S; Oshimi, K; Sasaki, M; Sugimoto, K; Takagi, M; Tamayose, K; Yamada, K1
Bodero, A; Khanna, KK; Lavin, MF; Lees-Miller, SP; Ye, R; Zhou, BB1
Fabisiak, JP; Kagan, VE; Ritov, VB1
Forrest, A; Gabrielli, B; Goldstone, S; Pavey, S; Sinnamon, J1
Piwnica-Worms, H; Zhao, H1
Coll, JL; Dubrez, L; Favrot, MC; Hurbin, A; Solary, E1
Cimprich, KA; Costanzo, V; Gautier, J; Gottesman, M; Lupardus, PJ; Shechter, D1
Beljin, M; Clifford, B; Stark, GR; Taylor, WR1
Hashimoto, C; Masui, S; Naito, M; Tsuruo, T1
Naito, M1
Chandna, S; Khaitan, D; Pati, U; Seth, RK; Suman, S1
Hayashi, K; Kimura, H; Nishida, H; Ohnari, I; Shirai, T; Takeuchi, A; Tomita, K; Tsuchiya, H1
Hayashi, K; Kitamura, S; Miwa, S; Nishida, H; Nojima, T; Shirai, T; Takeuchi, A; Tsuchiya, H1
Cui, XS; Kim, NH; Kwon, J; Lee, IW; Lin, Z; Luo, Y; Wang, H1

Reviews

2 review(s) available for etoposide and caffeine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Desmoplastic small round cell tumour successfully treated with caffeine-assisted chemotherapy: a case report and review of the literature.
    Anticancer research, 2010, Volume: 30, Issue:9

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brachial Plexus Neuropathies; Caffeine; Cisplatin; Combined Modality Therapy; Doxorubicin; Etoposide; Humans; Ifosfamide; Immunohistochemistry; In Situ Hybridization, Fluorescence; Magnetic Resonance Imaging; Male; Radiotherapy; Sarcoma, Small Cell

2010

Trials

1 trial(s) available for etoposide and caffeine

ArticleYear
Effect of chemotherapy combined with caffeine for osteosarcoma.
    Journal of cancer research and clinical oncology, 1992, Volume: 118, Issue:8

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Caffeine; Calcaneus; Chemotherapy, Adjuvant; Child; Cisplatin; Combined Modality Therapy; Doxorubicin; Etoposide; Female; Femoral Neoplasms; Humans; Ifosfamide; Infusions, Intra-Arterial; Male; Methotrexate; Osteosarcoma; Salvage Therapy; Tibia

1992

Other Studies

42 other study(ies) available for etoposide and caffeine

ArticleYear
Cheminformatic models to predict binding affinities to human serum albumin.
    Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25

    Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids

2001
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:3

    Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
    Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9

    Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
Predicting phospholipidosis using machine learning.
    Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5

    Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Rapid evaluation of topoisomerase inhibitors: caffeine inhibition of topoisomerases in vivo.
    Teratogenesis, carcinogenesis, and mutagenesis, 1990, Volume: 10, Issue:1

    Topics: Animals; Caffeine; Camptothecin; Etoposide; Haplorhini; Teniposide; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

1990
A topoisomerase II-dependent G2 cycle checkpoint in mammalian cells/.
    Nature, 1994, Dec-01, Volume: 372, Issue:6505

    Topics: Animals; Caffeine; Cell Line; Chromosomes; Diketopiperazines; DNA Damage; DNA Topoisomerases, Type II; Etoposide; G2 Phase; HeLa Cells; Humans; Mitosis; Muntjacs; Nocodazole; Piperazines; Topoisomerase II Inhibitors

1994
Concentration-dependent differences in the mechanisms by which caffeine potentiates etoposide cytotoxicity in HeLa cells.
    Cancer research, 1994, Sep-15, Volume: 54, Issue:18

    Topics: Apoptosis; Caffeine; Cell Death; Dose-Response Relationship, Drug; Drug Synergism; Etoposide; G2 Phase; HeLa Cells; Humans; Phosphorylation; Time Factors; Tyrosine

1994
Caffeine attenuates the action of amsacrine and etoposide in U-937 cells by mechanisms which involve inhibition of RNA synthesis.
    International journal of cancer, 1994, Jun-15, Volume: 57, Issue:6

    Topics: Amsacrine; Caffeine; Cell Differentiation; Cell Division; Chromatin; DNA Topoisomerases, Type II; DNA-Binding Proteins; DNA, Neoplasm; Etoposide; Humans; In Vitro Techniques; Neoplasm Proteins; RNA, Neoplasm; Tumor Cells, Cultured

1994
ts BCR-ABL kinase activation confers increased resistance to genotoxic damage via cell cycle block.
    Oncogene, 1996, Nov-21, Volume: 13, Issue:10

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Caffeine; Cell Line; Enzyme Induction; Etoposide; Fusion Proteins, bcr-abl; G1 Phase; G2 Phase; Interleukin-3; Mitosis; Phosphodiesterase Inhibitors; Phosphorylation; Protein Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Radiation Tolerance; Temperature

1996
A case of malignant peritoneal mesothelioma showed complete remission with chemotherapy.
    Japanese journal of clinical oncology, 1998, Volume: 28, Issue:2

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Caffeine; Cisplatin; Combined Modality Therapy; Drug Combinations; Etoposide; Female; Humans; Mesothelioma; Neoplasms, Unknown Primary; Peritoneal Neoplasms; Remission Induction; Tegafur; Uracil

1998
Nuclear export of cyclin B1 and its possible role in the DNA damage-induced G2 checkpoint.
    The EMBO journal, 1998, May-15, Volume: 17, Issue:10

    Topics: Animals; Binding Sites; Biological Transport; Caffeine; Carrier Proteins; Cell Nucleus; Cyclin B; Cyclin B1; Cytoplasm; DNA Damage; Etoposide; Exportin 1 Protein; Fatty Acids, Unsaturated; G2 Phase; HeLa Cells; Humans; Karyopherins; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins

1998
The G2 block induced by DNA damage: a caffeine-resistant component independent of Cdc25C, MPM-2 phosphorylation, and H1 kinase activity.
    Cancer research, 1998, Jun-15, Volume: 58, Issue:12

    Topics: Antineoplastic Agents, Phytogenic; Caffeine; CDC2 Protein Kinase; cdc25 Phosphatases; Cell Cycle Proteins; Central Nervous System Stimulants; DNA Damage; Epitopes; Etoposide; G2 Phase; HeLa Cells; Humans; Neoplasm Proteins; Phosphorylation; Protein Kinases; Tumor Cells, Cultured

1998
Quantitative measurement of mammalian chromosome mitotic loss rates using the green fluorescent protein.
    Journal of cell science, 1999, Volume: 112 ( Pt 16)

    Topics: Aneuploidy; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Buffers; Caffeine; Cell Fusion; Chromosome Aberrations; Chromosomes, Artificial, Yeast; Demecolcine; Etoposide; Flow Cytometry; Glucose; Green Fluorescent Proteins; HeLa Cells; Humans; In Situ Hybridization, Fluorescence; Indicators and Reagents; Luminescent Proteins; Mammals; Mice; Mitosis; Nocodazole; Phosphodiesterase Inhibitors; Plasmids; Yeasts

1999
The bacterial cytolethal distending toxin (CDT) triggers a G2 cell cycle checkpoint in mammalian cells without preliminary induction of DNA strand breaks.
    Oncogene, 1999, Nov-04, Volume: 18, Issue:46

    Topics: Antineoplastic Agents, Phytogenic; Bacterial Toxins; Caffeine; CDC2 Protein Kinase; cdc25 Phosphatases; Cell Division; DNA Damage; DNA Replication; DNA, Neoplasm; Etoposide; G2 Phase; HeLa Cells; Humans; Neoplasm Proteins; Phosphorylation; Protein Processing, Post-Translational; Recombinant Fusion Proteins; S Phase

1999
Distinct Chk2 activation pathways are triggered by genistein and DNA-damaging agents in human melanoma cells.
    The Journal of biological chemistry, 2000, May-19, Volume: 275, Issue:20

    Topics: Caffeine; cdc25 Phosphatases; Cell Cycle; Cell Cycle Proteins; Cell Division; Checkpoint Kinase 2; Choroid Neoplasms; DNA Damage; Doxorubicin; Enzyme Activation; Etoposide; G2 Phase; Genistein; Humans; Melanoma; Protein Kinases; Protein Serine-Threonine Kinases; Tumor Cells, Cultured

2000
Activation of an ataxia telangiectasia mutation-dependent intra-S-phase checkpoint by anti-tumour drugs in HL-60 and human lymphoblastoid cells.
    British journal of haematology, 2000, Volume: 110, Issue:4

    Topics: Antimetabolites; Antineoplastic Agents; Ataxia Telangiectasia Mutated Proteins; Bromodeoxyuridine; Caffeine; Cell Cycle Proteins; Cell Line, Transformed; Cytarabine; DNA-Binding Proteins; Doxorubicin; Etoposide; Flow Cytometry; Gene Expression; HL-60 Cells; Humans; Mutation; Phosphodiesterase Inhibitors; Protein Serine-Threonine Kinases; S Phase; Signal Transduction; Topoisomerase II Inhibitors; Tumor Suppressor Proteins

2000
The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent manner.
    The Journal of biological chemistry, 2001, Feb-16, Volume: 276, Issue:7

    Topics: Androstadienes; Ataxia Telangiectasia Mutated Proteins; Benzoquinones; Caffeine; Cell Cycle Proteins; Cell Line; Checkpoint Kinase 2; DNA Fragmentation; DNA-Binding Proteins; Enzyme Inhibitors; Etoposide; Genistein; Humans; Lactams, Macrocyclic; Mutation; Phosphorylation; Plants, Medicinal; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Quinones; Rifabutin; Topoisomerase II Inhibitors; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Wortmannin

2001
Reversible thiol-dependent activation of ryanodine-sensitive Ca2+ release channel by etoposide (VP-16) phenoxyl radical.
    Antioxidants & redox signaling, 2000,Spring, Volume: 2, Issue:1

    Topics: Adenosine Triphosphate; Animals; Caffeine; Calcium; Calcium Signaling; Calcium-Transporting ATPases; Dithiothreitol; Enzyme Inhibitors; Etoposide; Free Radicals; Homeostasis; Ion Transport; Monophenol Monooxygenase; Muscle Proteins; Muscle, Skeletal; Oxidation-Reduction; Oxidative Stress; Phenols; Rabbits; Ruthenium Red; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Sulfhydryl Reagents

2000
Cdc25-dependent activation of cyclin A/cdk2 is blocked in G2 phase arrested cells independently of ATM/ATR.
    Oncogene, 2001, Feb-22, Volume: 20, Issue:8

    Topics: Ataxia Telangiectasia Mutated Proteins; Caffeine; CDC2-CDC28 Kinases; cdc25 Phosphatases; Cell Cycle Proteins; Cyclin A; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; DNA Damage; DNA-Binding Proteins; Enzyme Activation; Etoposide; G2 Phase; Humans; Mutagens; Protein Serine-Threonine Kinases; Tumor Cells, Cultured; Tumor Suppressor Proteins

2001
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1.
    Molecular and cellular biology, 2001, Volume: 21, Issue:13

    Topics: Adenoviridae; Amino Acid Motifs; Antineoplastic Agents; Ataxia Telangiectasia Mutated Proteins; Caffeine; Cell Cycle; Cell Cycle Proteins; Cell Line; Checkpoint Kinase 1; Cisplatin; Cytarabine; DNA Damage; Enzyme Activation; Etoposide; Genes, Reporter; Humans; Hydroxyurea; Immunoblotting; Nucleic Acid Synthesis Inhibitors; Phosphodiesterase Inhibitors; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphoserine; Protein Kinases; Protein Serine-Threonine Kinases; Recombinant Fusion Proteins

2001
Caffeine sensitizes human H358 cell line to p53-mediated apoptosis by inducing mitochondrial translocation and conformational change of BAX protein.
    The Journal of biological chemistry, 2001, Oct-19, Volume: 276, Issue:42

    Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Caffeine; Cell Death; Cell Line; Central Nervous System Stimulants; Cisplatin; Cytosol; Dose-Response Relationship, Drug; Etoposide; Genes, p53; Humans; Mitochondria; Nucleic Acid Synthesis Inhibitors; Plasmids; Protein Conformation; Protein Transport; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Transfection; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Vincristine; Xanthines

2001
An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication.
    Molecular cell, 2003, Volume: 11, Issue:1

    Topics: Animals; Aphidicolin; Ataxia Telangiectasia Mutated Proteins; Caffeine; Cell Cycle Proteins; Chromatin; DNA; DNA Damage; DNA Replication; Enzyme Inhibitors; Etoposide; Exonucleases; Humans; Macromolecular Substances; Male; Nucleic Acid Synthesis Inhibitors; Oocytes; Phosphoproteins; Protein Serine-Threonine Kinases; Signal Transduction; Spermatozoa; Xenopus laevis; Xenopus Proteins

2003
G2 arrest in response to topoisomerase II inhibitors: the role of p53.
    Cancer research, 2003, Jul-15, Volume: 63, Issue:14

    Topics: Caffeine; CDC2 Protein Kinase; Cyclin B; Cyclin B1; Down-Regulation; Drug Interactions; Enzyme Inhibitors; Etoposide; Fibrosarcoma; G2 Phase; Humans; Mitosis; Thiobarbiturates; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2003
Caspase-independent necrotic cell death induced by a radiosensitizer, 8-nitrocaffeine.
    Cancer science, 2004, Volume: 95, Issue:4

    Topics: Antibodies, Monoclonal; Antimycin A; Caffeine; Caspases; Cell Death; Cell Hypoxia; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Drug Resistance, Multiple; Etoposide; fas Receptor; Fibrosarcoma; Free Radical Scavengers; HL-60 Cells; Humans; Jurkat Cells; K562 Cells; Necrosis; Radiation-Sensitizing Agents; Reactive Oxygen Species; U937 Cells; Xanthines

2004
[Screening for apoptosis inducers].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:4

    Topics: Apoptosis; Caffeine; Cell Death; Etoposide; Humans; Reactive Oxygen Species; U937 Cells

2004
Stress response of a p53 homologue in the radioresistant Sf9 insect cells.
    International journal of radiation biology, 2009, Volume: 85, Issue:3

    Topics: Active Transport, Cell Nucleus; Amino Acid Sequence; Animals; Ataxia Telangiectasia Mutated Proteins; Caffeine; Cell Cycle Proteins; Cell Line; Cell Line, Tumor; Cell Nucleus; Cytoplasm; DNA Damage; DNA-Binding Proteins; Etoposide; Gamma Rays; Humans; Insect Proteins; Molecular Sequence Data; Protein Serine-Threonine Kinases; Radiation Tolerance; Sequence Homology, Amino Acid; Spodoptera; Tumor Suppressor Protein p53; Tumor Suppressor Proteins

2009
Caffeine-potentiated chemotherapy for metastatic osteosarcoma.
    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 2009, Volume: 14, Issue:5

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Caffeine; Child; Cisplatin; Doxorubicin; Etoposide; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Osteosarcoma; Young Adult

2009
Effect of ATM and HDAC Inhibition on Etoposide-Induced DNA Damage in Porcine Early Preimplantation Embryos.
    PloS one, 2015, Volume: 10, Issue:11

    Topics: Animals; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Blastocyst; Caffeine; DNA Damage; Embryonic Development; Etoposide; Female; Gene Expression Regulation; Histone Deacetylase Inhibitors; Morpholines; Pregnancy; Pyrones; Receptors, Peptide; Swine; Topoisomerase II Inhibitors

2015