Page last updated: 2024-09-03

etomoxir and oleic acid

etomoxir has been researched along with oleic acid in 14 studies

Compound Research Comparison

Studies
(etomoxir)
Trials
(etomoxir)
Recent Studies (post-2010)
(etomoxir)
Studies
(oleic acid)
Trials
(oleic acid)
Recent Studies (post-2010) (oleic acid)
2608938,7682483,051

Protein Interaction Comparison

ProteinTaxonomyetomoxir (IC50)oleic acid (IC50)
Tyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)6.2

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (28.57)18.2507
2000's5 (35.71)29.6817
2010's5 (35.71)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Björntorp, P; Lönnroth, P; Smith, U; Svedberg, J2
Grill, VE; Zhou, YP1
Brandt, JM; Djouadi, F; Kelly, DP1
Cnop, M; Eizirik, DL; Hannaert, JC; Hoorens, A; Pipeleers, DG1
Biden, TJ; Cazzolli, R; Craig, DL; Schmitz-Peiffer, C1
Mishra, R; Simonson, MS1
Hermansen, K; Hong, J; Jeppesen, PB; Nordentoft, I1
Boysen, G; Brooks, NL; Carling, D; Combs, TP; Flurkey, K; Harrison, DE; Jeong, YC; Khodush, VR; Klebanov, S; Kupper, LL; Patel, KB; Perfetti, MT; Raetzsch, CF; Swenberg, JA; Trent, CM1
Cruz-Garcia, L; Gutiérrez, J; Navarro, I; Sánchez-Gurmaches, J1
Czaja, MJ; Fiel, MI; Friedman, SL; Ghiassi-Nejad, Z; Gordon, R; Hernández-Gea, V; Rozenfeld, R; Yue, Z1
Huang, G; Li, J; Liu, J; Miao, P; Song, S; Sun, X; Zhang, T; Zhao, L; Zhao, S; Zhao, X; Zhou, X1
Bakhteeva, VT; Fedorova, EV; Fok, EM; Lavrova, EA; Parnova, RG1

Other Studies

14 other study(ies) available for etomoxir and oleic acid

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Effect of free fatty acids on insulin receptor binding and tyrosine kinase activity in hepatocytes isolated from lean and obese rats.
    Diabetes, 1992, Volume: 41, Issue:3

    Topics: Animals; Cells, Cultured; Epoxy Compounds; Fatty Acids, Nonesterified; Hypoglycemic Agents; Insulin; Kinetics; Liver; Male; Obesity; Oleic Acid; Oleic Acids; Protein-Tyrosine Kinases; Rats; Rats, Inbred Strains; Receptor, Insulin; Reference Values

1992
Prevention of inhibitory effect of free fatty acids on insulin binding and action in isolated rat hepatocytes by etomoxir.
    Diabetes, 1991, Volume: 40, Issue:6

    Topics: Aminoisobutyric Acids; Animals; Biological Transport; Cells, Cultured; Dose-Response Relationship, Drug; Epoxy Compounds; Hypoglycemic Agents; Insulin; Kinetics; Liver; Male; Oleic Acid; Oleic Acids; Rats; Rats, Inbred Strains; Receptor, Insulin

1991
Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle.
    The Journal of clinical investigation, 1994, Volume: 93, Issue:2

    Topics: Animals; Caprylates; Carnitine O-Palmitoyltransferase; Cells, Cultured; Epoxy Compounds; Ethanol; Fatty Acids, Nonesterified; Glucose; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Keto Acids; Kinetics; Male; Oleic Acid; Oleic Acids; Palmitic Acid; Palmitic Acids; Proinsulin; Protein Biosynthesis; Proteins; Rats; Rats, Sprague-Dawley; Time Factors

1994
Fatty acids activate transcription of the muscle carnitine palmitoyltransferase I gene in cardiac myocytes via the peroxisome proliferator-activated receptor alpha.
    The Journal of biological chemistry, 1998, Sep-11, Volume: 273, Issue:37

    Topics: Animals; Animals, Newborn; Base Sequence; Carnitine O-Palmitoyltransferase; Cells, Cultured; Cloning, Molecular; Epoxy Compounds; Fatty Acids, Nonesterified; Genes, Reporter; Humans; Luciferases; Mice; Mice, Knockout; Muscle, Skeletal; Myocardium; Oleic Acid; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Regulatory Sequences, Nucleic Acid; Repetitive Sequences, Nucleic Acid; RNA, Messenger; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection

1998
Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation.
    Diabetes, 2001, Volume: 50, Issue:8

    Topics: Animals; Apoptosis; Carnitine O-Palmitoyltransferase; Cell Survival; Cells, Cultured; Cytoplasm; Enzyme Inhibitors; Epoxy Compounds; Fatty Acids, Nonesterified; Islets of Langerhans; Kinetics; Male; Oleic Acid; Palmitic Acid; Palmitic Acids; Rats; Rats, Wistar; Time Factors; Triglycerides

2001
Inhibition of glycogen synthesis by fatty acid in C(2)C(12) muscle cells is independent of PKC-alpha, -epsilon, and -theta.
    American journal of physiology. Endocrinology and metabolism, 2002, Volume: 282, Issue:6

    Topics: Animals; Cell Line; Enzyme Activation; Enzyme Inhibitors; Epoxy Compounds; Fatty Acids, Unsaturated; Gene Expression; Glycogen; Immunoblotting; Insulin; Isoenzymes; Kinetics; Lipid Metabolism; Mice; Mitochondria; Muscles; Mutation; Oleic Acid; Oxidation-Reduction; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-epsilon; Protein Kinase C-theta; Transfection

2002
Saturated free fatty acids and apoptosis in microvascular mesangial cells: palmitate activates pro-apoptotic signaling involving caspase 9 and mitochondrial release of endonuclease G.
    Cardiovascular diabetology, 2005, Jan-10, Volume: 4

    Topics: Apoptosis; Blotting, Western; Caspase 9; Caspases; Cells, Cultured; Cytochromes c; Endodeoxyribonucleases; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Epoxy Compounds; Humans; Linoleic Acid; Mesangial Cells; Mitochondria; Oleic Acid; Palmitates; Signal Transduction; Stearates

2005
Fatty acid-induced effect on glucagon secretion is mediated via fatty acid oxidation.
    Diabetes/metabolism research and reviews, 2007, Volume: 23, Issue:3

    Topics: Animals; Carnitine O-Palmitoyltransferase; DNA; Epoxy Compounds; Fatty Acids; Gene Expression Regulation; Glucagon; Glucagon-Secreting Cells; Mice; Oleic Acid; Oxidation-Reduction; Palmitic Acid; Triglycerides; Tumor Cells, Cultured

2007
Low utilization of circulating glucose after food withdrawal in Snell dwarf mice.
    The Journal of biological chemistry, 2007, Nov-30, Volume: 282, Issue:48

    Topics: Animals; Aorta; Body Composition; Cattle; Coumaric Acids; Epoxy Compounds; Fatty Acids; Female; Food Deprivation; Glucose; Glycogenolysis; Mice; Mice, Inbred C57BL; Mutation; Oleic Acid; Oxygen; Reactive Oxygen Species; Triglycerides

2007
Endocrine control of oleic acid and glucose metabolism in rainbow trout (Oncorhynchus mykiss) muscle cells in culture.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2010, Volume: 299, Issue:2

    Topics: Animals; Carbon Dioxide; Carnitine O-Palmitoyltransferase; Catecholamines; Cells, Cultured; Energy Metabolism; Epoxy Compounds; Glucose; Glycogen; Hypoglycemic Agents; Insulin; Insulin-Like Growth Factor I; Intracellular Signaling Peptides and Proteins; Muscle Fibers, Skeletal; Oleic Acid; Oncorhynchus mykiss; Oxidation-Reduction; PPAR gamma; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Rosiglitazone; Sirolimus; Thiazolidinediones; TOR Serine-Threonine Kinases; Triglycerides

2010
Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues.
    Gastroenterology, 2012, Volume: 142, Issue:4

    Topics: Adenine; Adenosine Triphosphate; Animals; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Carbon Tetrachloride; Cell Line; Energy Metabolism; Epoxy Compounds; Fibroblasts; Hepatic Stellate Cells; Humans; Idiopathic Pulmonary Fibrosis; Kidney; Lipid Metabolism; Liver; Liver Cirrhosis, Experimental; Lung; Mice; Mice, Inbred C57BL; Mice, Knockout; Microtubule-Associated Proteins; Oleic Acid; RNA Interference; Thioacetamide

2012
Inhibition of lipolysis by mercaptoacetate and etomoxir specifically sensitize drug-resistant lung adenocarcinoma cell to paclitaxel.
    PloS one, 2013, Volume: 8, Issue:9

    Topics: Adenocarcinoma; Antineoplastic Agents; Carbon Dioxide; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Enzyme Inhibitors; Epoxy Compounds; Glucose; Glycolysis; Humans; Lipolysis; Lung Neoplasms; Oleic Acid; Oxidative Phosphorylation; Paclitaxel; Thioglycolates

2013
[Deposition of exogenous and endogenously generated unsaturated fatty acids in lipid droplets triacylglycerol as a mechanism of its sequestration in epithelial cells].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2014, Volume: 100, Issue:8

    Topics: Animals; Arachidonic Acid; Biological Transport; Carnitine O-Palmitoyltransferase; Cholesterol Esters; Cyclooxygenase 1; Cyclooxygenase 2; Diclofenac; Dinoprostone; Enzyme Inhibitors; Epithelial Cells; Epoxy Compounds; Lipid Droplets; Lipid Metabolism; Oleic Acid; Primary Cell Culture; Rana temporaria; Triglycerides; Tritium; Urinary Bladder; Urothelium

2014