Compounds > etomoxir
Page last updated: 2024-09-03

etomoxir and cyclosporine

etomoxir has been researched along with cyclosporine in 4 studies

Compound Research Comparison

Studies
(etomoxir)		Trials
(etomoxir)		Recent Studies (post-2010)
(etomoxir)		Studies
(cyclosporine)		Trials
(cyclosporine)		Recent Studies (post-2010) (cyclosporine)
2608933772170
26089330,5473,8026,558

Protein Interaction Comparison

ProteinTaxonomyetomoxir (IC50)cyclosporine (IC50)
ATP-binding cassette sub-family C member 3Homo sapiens (human)0.6315
Bile salt export pumpRattus norvegicus (Norway rat)0.6
Bile salt export pumpHomo sapiens (human)3.5
Interleukin-2Mus musculus (house mouse)0.005
ATP-dependent translocase ABCB1Mus musculus (house mouse)0.7
ATP-dependent translocase ABCB1Homo sapiens (human)1.6792
Cytochrome P450 3A4Homo sapiens (human)3.734
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 25.82
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)9.34
Cytochrome P450 3A5Homo sapiens (human)2.06
ATP-dependent translocase ABCB1Mus musculus (house mouse)4.8
Substance-K receptorHomo sapiens (human)4.139
Peptidyl-prolyl cis-trans isomerase BHomo sapiens (human)0.0088
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)9.34
Cytochrome P450 3A7Homo sapiens (human)2.06
Cytochrome P450 2C19Homo sapiens (human)7
Multidrug resistance-associated protein 1 Homo sapiens (human)3.5082
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)9.34
Peptidyl-prolyl cis-trans isomerase A Homo sapiens (human)0.0252
Peptidyl-prolyl cis-trans isomerase FKBP4Homo sapiens (human)0.016
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoformHomo sapiens (human)0.183
Peptidyl-prolyl cis-trans isomerase DHomo sapiens (human)0.0036
Sodium/bile acid cotransporterHomo sapiens (human)1
Reverse transcriptase/RNaseH Human immunodeficiency virus 10.455
Cytochrome P450 3A43 Homo sapiens (human)2.06
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Mus musculus (house mouse)0.57
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)1.3
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)4.3
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)0.95

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (25.00)29.6817
2010's3 (75.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Aleo, MD; Bonin, PD; Luo, Y; Potter, DM; Swiss, R; Will, Y1
Anderson, NL; Steiner, S1
Anderson, EJ; Davis, B; Murphy, MP; Neufer, PD; Robidoux, J; Rogers, C1

Other Studies

4 other study(ies) available for etomoxir and cyclosporine

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump.
    Hepatology (Baltimore, Md.), 2014, Volume: 60, Issue:3

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Chemical and Drug Induced Liver Injury; Humans; Male; Mitochondria, Liver; Rats; Rats, Sprague-Dawley; Severity of Illness Index

2014
Pharmaceutical proteomics.
    Annals of the New York Academy of Sciences, 2000, Volume: 919

    Topics: Animals; Cyclosporine; Drug Design; Drug-Related Side Effects and Adverse Reactions; Epoxy Compounds; Gene Expression; Gene Expression Profiling; Humans; Liver; Proteome

2000
A transient increase in lipid peroxidation primes preadipocytes for delayed mitochondrial inner membrane permeabilization and ATP depletion during prolonged exposure to fatty acids.
    Free radical biology & medicine, 2014, Volume: 67

    Topics: Adenosine Triphosphate; Adipocytes; Carnosine; Cell Death; Cell Differentiation; Cell Line, Transformed; Cyclosporine; Epoxy Compounds; Fatty Acids; Gene Expression; Humans; Lipid Peroxidation; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Membranes; Organophosphorus Compounds; Oxidative Stress; Permeability; Piperidines; Reactive Oxygen Species; Superoxides; Ubiquinone

2014