ethylphenylhydantoin has been researched along with mephenytoin in 30 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (60.00) | 18.7374 |
| 1990's | 6 (20.00) | 18.2507 |
| 2000's | 6 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| MacMillan, SF; Raisys, VA; Zebelman, AM | 1 |
| Bircher, J; Küpfer, A; Preisig, R | 1 |
| Devor, DE; Diwan, BA; Dragnev, KH; Jones, CR; Lubet, RA; Miller, MS; Nims, RW; Rice, JM; Ward, JM | 1 |
| Pezeshk, A; Pezeshk, V | 1 |
| Diwan, BA; Hu, H; Lubet, RA; Nims, RW; Rice, JM; Ward, JM | 1 |
| Alpin, RS; Day, PA; Hall, IH; Maguire, JH; Wong, OT | 1 |
| Fujioka, H; Kishi, M; Masuda, Y; Miyazaki, H; Tan, T; Yokoyama, Y | 1 |
| Inaba, T | 1 |
| Inaba, T; Jurima, M; Kalow, W | 1 |
| Kalow, W | 1 |
| Desai, BT; Kupferberg, HJ; Newmark, ME; Penry, JK; Porter, RJ; Theodore, WH; Yonekawa, WD | 1 |
| Küpfer, A; Preisig, R | 1 |
| Branch, RA; McAllister, CB; Sweetman, BJ; Wedlund, PJ; Wilkinson, GR | 1 |
| Branch, RA; Küpfer, A; Patwardhan, R; Preisig, R; Schenker, S; Ward, S | 1 |
| Harbison, RD; Küpfer, A; Lawson, JA; Wells, PG | 1 |
| Roeda, D; Westera, G | 1 |
| Lubet, RA; Mellini, DW; Nelson, VC; Nims, RW; Omiecinski, CJ; Sidhu, JS; Thomas, PE | 1 |
| Diwan, BA; Lubet, RA; Mellini, DW; Nims, RW; Thomas, PE; Utermahlen, WE | 1 |
| Heyn, H; Stevens, JC; White, RB | 1 |
| Desta, Z; Flockhart, DA; Ko, JW | 1 |
| Ashton, M; Jansson, B; Simonsson, US | 1 |
| BUTLER, TC | 2 |
| BUTLER, TC; WADDELL, WJ | 1 |
| CRAVIOTTO, C | 1 |
| Davila, J; Fackenthal, JD; Hancock, ML; Lamba, J; Lamba, V; Ring, B; Rogan, PK; Schuetz, EG; Strom, S; Wrighton, SA; Yasuda, K | 1 |
| Fuhr, U; Harlfinger, S; Kasel, D; Klaassen, T | 1 |
| Jones, JP; Kneller, MB; Rettie, AE; Rock, DA; Suzuki, H; Trager, WF | 1 |
| Elsherbiny, D; Jansson, B; Simonsson, US | 1 |
| Fuhr, U; Jaehde, U; Jetter, A; Kasel, D; Kirchheiner, J; Klaassen, T; Tomalik-Scharte, D | 1 |
1 review(s) available for ethylphenylhydantoin and mephenytoin
| Article | Year |
|---|---|
Genetic polymorphism of mephenytoin metabolism.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chemical Phenomena; Chemistry; China; Cytochrome P-450 CYP2C19; Debrisoquin; Dogs; Ethnicity; Humans; Hydantoins; Hydroxylation; Japan; Kinetics; Liver; Mephenytoin; Mephobarbital; Mice; Mixed Function Oxygenases; Ontario; Phenotype; Polymorphism, Genetic; Sparteine; Tennessee; White People | 1986 |
29 other study(ies) available for ethylphenylhydantoin and mephenytoin
| Article | Year |
|---|---|
Gas-chromatographic determination of mephenytoin and desmethylmephenytoin, after off-column alkylation.
Topics: Alkylation; Chromatography, Gas; Humans; Hydantoins; Mephenytoin | 1979 |
Stereoselective metabolism, pharmacokinetics and biliary elimination of phenylethylhydantoin (Nirvanol) in the dog.
Topics: Animals; Bile; Chromatography, Gas; Dogs; Female; Hydantoins; Kinetics; Mephenytoin; Stereoisomerism | 1977 |
A markedly diminished pleiotropic response to phenobarbital and structurally-related xenobiotics in Zucker rats in comparison with F344/NCr or DA rats.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Barbital; Base Sequence; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Epoxide Hydrolases; Female; Glutathione Transferase; Liver; Mephenytoin; Molecular Sequence Data; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred F344; Rats, Zucker; Steroid Hydroxylases; Xenobiotics | 1992 |
Drug-metal interactions: spectroscopic studies of copper hydantoin complexes.
Topics: Copper; Crystallization; Electron Spin Resonance Spectroscopy; Hydantoins; Mephenytoin; Molecular Structure; Phenytoin; Pyridines; Spectrophotometry, Infrared | 1991 |
P-450 enzyme induction by 5-ethyl-5-phenylhydantoin and 5,5-diethylhydantoin, analogues of barbiturate tumor promoters phenobarbital and barbital, and promotion of liver and thyroid carcinogenesis initiated by N-nitrosodiethylamine in rats.
Topics: Animals; Barbital; Barbiturates; Body Weight; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Enzyme Induction; Hydantoins; Liver; Liver Neoplasms, Experimental; Male; Mephenytoin; Organ Size; Phenobarbital; Rats; Rats, Inbred F344; Thyroid Neoplasms | 1988 |
A comparison of the S(+) and R(-) enantiomers of 5-ethyl-5-phenylhydantoin as hypolipidemic agents in rodents.
Topics: Administration, Oral; Animals; Cholesterol; Feces; Hydantoins; Hypolipidemic Agents; Injections, Intraperitoneal; Intestine, Small; Isomerism; Lipid Metabolism; Lipoproteins; Liver; Male; Mephenytoin; Mice; Rats; Rats, Inbred Strains; Reference Values; Structure-Activity Relationship; Triglycerides | 1987 |
Biopharmaceutical studies on hydantoin derivatives. V. Pharmacokinetics and pharmacodynamics of 5,5-diphenylhydantoin and 1-benzenesulfonyl-5,5-diphenylhydantoin.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Anticonvulsants; Brain; Dinoprostone; Injections, Intravenous; Injections, Intraventricular; Liver; Male; Mephenytoin; Mice; Phenytoin; Prostaglandins E; Protein Binding; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1986 |
Family studies of mephenytoin hydroxylation deficiency.
Topics: Adolescent; Adult; Female; Genes, Recessive; Humans; Hydantoins; Hydroxylation; Male; Mephenytoin; Middle Aged; Pedigree; Phenotype | 1986 |
The genetic defect of mephenytoin hydroxylation.
Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Gene Frequency; Genetic Variation; Genetics, Medical; Half-Life; Humans; Kinetics; Mephenytoin; Mixed Function Oxygenases; Structure-Activity Relationship | 1986 |
Disposition of mephenytoin and its metabolite, nirvanol, in epileptic patients.
Topics: Adolescent; Adult; Epilepsies, Partial; Female; Humans; Hydantoins; Male; Mephenytoin | 1984 |
Pharmacogenetics of mephenytoin: a new drug hydroxylation polymorphism in man.
Topics: Adult; Debrisoquin; Female; Humans; Hydantoins; Hydroxylation; Male; Mephenytoin; Phenotype; Polymorphism, Genetic | 1984 |
Direct enantiomeric resolution of mephenytoin and its N-demethylated metabolite in plasma and blood using chiral capillary gas chromatography.
Topics: Anticonvulsants; Chromatography, Gas; Half-Life; Humans; Hydantoins; Mephenytoin; Stereoisomerism | 1984 |
Stereoselective metabolism and pharmacogenetic control of 5-phenyl-5-ethylhydantoin (nirvanol) in humans.
Topics: Adolescent; Adult; Anticonvulsants; Half-Life; Humans; Hydantoins; Male; Mephenytoin; Stereoisomerism; Time Factors | 1984 |
Relation of in vivo drug metabolism to stereoselective fetal hydantoin toxicology in mouse: evaluation of mephenytoin and its metabolite, nirvanol.
Topics: Animals; Embryo, Mammalian; Female; Fetus; Hydantoins; Mephenytoin; Mice; Mice, Inbred ICR; Pregnancy; Stereoisomerism | 1982 |
The synthesis of some 11C-labelled antiepileptic drugs with potential utility as radiopharmaceuticals: hydantoins and barbiturates.
Topics: Anticonvulsants; Barbital; Barbiturates; Carbon Radioisotopes; Hydantoins; Isotope Labeling; Mephenytoin; Phenobarbital; Phenytoin | 1981 |
Absence of enantioselectivity in the pharmacodynamics of P450 2B induction by 5-ethyl-5-phenylhydantoin in the male rat liver or in cultured rat hepatocytes.
Topics: Animals; Cells, Cultured; Cytochrome P-450 Enzyme System; Enzyme Induction; Liver; Male; Mephenytoin; Organ Size; Rats; Rats, Inbred F344; RNA; Stereoisomerism | 1994 |
Hepatic cytochrome P450 2B induction by ethyl/phenyl-substituted congeners of phenobarbital in the B6C3F1 mouse.
Topics: Animals; Anticonvulsants; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Liver; Male; Mephenytoin; Mice; Phenobarbital; Phenols; Rats; Rats, Inbred F344; Species Specificity; Structure-Activity Relationship | 1994 |
Catalytic role of cytochrome P4502B6 in the N-demethylation of S-mephenytoin.
Topics: Antibodies, Monoclonal; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Isoenzymes; Kinetics; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Recombinant Proteins; Troleandomycin | 1996 |
Human N-demethylation of (S)-mephenytoin by cytochrome P450s 2C9 and 2B6.
Topics: Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Humans; Isoenzymes; Kinetics; Mephenytoin; Methylation; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenotype; Stereoisomerism; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Substrate Specificity | 1998 |
Simultaneous enantiospecific separation and quantitation of mephenytoin and its metabolites nirvanol and 4'-hydroxymephenytoin in human plasma by liquid chromatography.
Topics: Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Humans; Mephenytoin; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Stereoisomerism | 2003 |
Quantitative studies of the physiological disposition of 3-methyl-5-ethyl-5-phenyl hydantoin (mesantoin) and 5-ethyl-5-phenyl hydantoin (nirvanol).
Topics: Anticonvulsants; Blood; Humans; Hydantoins; Imidazoles; Mephenytoin | 1953 |
A pharmacological comparison of the optical isomers of 5-ethyl-5-phenyl hydantoin (nirvanol) and of 3-methyl-5-ethyl-5-phenyl hydantoin (mesantoin).
Topics: Anticonvulsants; Hydantoins; Imidazoles; Mephenytoin | 1954 |
The metabolic conversion of 3-methyl-5-ethyl-5-phenyl hydantoin (mesantoin) and of 5-ethyl-5-phenyl hydantoin (nirvanol) to 5 - ethyl -5- (p-hydroxyphenyl) hydantoin.
Topics: Anticonvulsants; Hydantoins; Imidazoles; Mephenytoin | 1956 |
[Experimental ophthalmopathic syndrome in guinea pigs caused by prolonged administration of 3-methyl-5-ethylphenylhydantoin].
Topics: Animals; Cataract; Eye Diseases; Guinea Pigs; Hydantoins; Keratitis; Mephenytoin | 1961 |
Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alternative Splicing; Amino Acid Sequence; Aryl Hydrocarbon Hydroxylases; Biotransformation; Black People; Blotting, Western; Child; Child, Preschool; Coxsackie and Adenovirus Receptor-Like Membrane Protein; Cytochrome P-450 CYP2B6; Ethnicity; Female; Genetic Linkage; Haplotypes; Hispanic or Latino; Humans; Infant; Introns; Liver; Male; Mephenytoin; Microsomes, Liver; Middle Aged; Molecular Sequence Data; Oxidoreductases, N-Demethylating; Polymorphism, Genetic; Promoter Regions, Genetic; Receptors, Virus; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sex Characteristics; White People | 2003 |
Quantification of mephenytoin and its metabolites 4'-hydroxymephenytoin and nirvanol in human urine using a simple sample processing method.
Topics: Aryl Hydrocarbon Hydroxylases; Calibration; Chromatography, Liquid; Cytochrome P-450 CYP2C19; Humans; Male; Mass Spectrometry; Mephenytoin; Mixed Function Oxygenases; Molecular Structure; Reference Standards; Reproducibility of Results; Sensitivity and Specificity | 2004 |
Active-site characteristics of CYP2C19 and CYP2C9 probed with hydantoin and barbiturate inhibitors.
Topics: Aryl Hydrocarbon Hydroxylases; Barbiturates; Binding Sites; Computer Simulation; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Drug Design; Enzyme Activation; Hydantoins; Mephenytoin; Mixed Function Oxygenases; Models, Chemical; Models, Molecular; Phenobarbital; Phenytoin; Protein Binding | 2004 |
Enantiospecific separation and quantitation of mephenytoin and its metabolites nirvanol and 4'-hydroxymephenytoin in human plasma and urine by liquid chromatography/tandem mass spectrometry.
Topics: Chromatography, Liquid; Humans; Mass Spectrometry; Mephenytoin; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism | 2006 |
Assessment of urinary mephenytoin metrics to phenotype for CYP2C19 and CYP2B6 activity.
Topics: Adult; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Data Interpretation, Statistical; Humans; Male; Mass Spectrometry; Mephenytoin; Middle Aged; Oxidoreductases, N-Demethylating; Phenotype; Phenytoin | 2008 |