Page last updated: 2024-08-21

ethylnitrosourea and methyl methanesulfonate

ethylnitrosourea has been researched along with methyl methanesulfonate in 81 studies

Research

Studies (81)

Timeframe	Studies, this research(%)	All Research%
pre-1990	23 (28.40)	18.7374
1990's	41 (50.62)	18.2507
2000's	12 (14.81)	29.6817
2010's	5 (6.17)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Ishikawa, T; Kitagawa, T; Takayama, S	1
Reygers, U; Thielmann, HW; Vosberg, HP	1
Merrifield, RK; Shooter, KV	1
Tates, AD	1
Blonsky, KS; Lee, GS; Morgan, AR; Savage, EA; Van On, DL; von Borstel, RC	1
Gibson, NW; Prakash, AS	1
Nivard, MJ; Pastink, A; Vogel, EW	1
Link, A; Tempel, K	1
Erickson, LC	1
Heddle, JA; Khan, MA	1
Berger, NA; Berger, SJ; Chatterjee, S; Cheng, MF	1
Magnusson, J; Ramel, C	1
Kroese, ED; Meerman, JH; Mohn, GR; Zeilmaker, MJ	1
Vogel, EW; Zijlstra, JA	1
Faustman, EM; Gage, D; Kirby, Z; Varnum, M	1
den Engelse, L; Tates, AD	1
Brent, TP	1
Babich, MA; Day, RS	1
Goth-Goldstein, R; Hughes, M	1
de Vogel, N; den Engelse, L; Menkveld, GJ; Neuteboom, I; Rotteveel, AH; Tates, AD	1
Herrera, RJ; Luckett, DC; Mukherjee, AB	1
Aune, T; Deilhaug, T; Haugen, A; Krokan, H; Myrnes, B	1
Eeken, JC; Sobels, FH	1
Schrotel, KR; Skare, JA	1
Natarajan, AT; Simons, JW; van Zeeland, AA; Vogel, EW	1
Dornish, JM; Markussen, G; Smith-Kielland, I	1
Kaina, B	1
Morgan, WF; Schwartz, JL; Wolff, S	1
Ide, F; Ishikawa, T; Takayama, S	1
Aslanian, MM; Kim, AI	1
Davnichenko, LS; Rapoport, IA; Vasil'eva, SV	1
Jenssen, D; Ramel, C	1
Comendador, MA; Ferreiro, JA; Sierra, LM	1
Faustman, EM; Seeley, MR	3
Creus, A; Marcos, R; Soriano, S; Xamena, N	1
Aguirrezabalaga, I; Comendador, MA; Sierra, LM	1
Heddle, JA; Tao, KS	1
Hamilton, JW; McCaffrey, J	1
Boerrigter, ME; Vijg, J	1
Cunningham, JM; Delaney, CA; Di Matteo, M; Dunger, A; Green, IC; Green, MH	1
Cabré, O; Creus, A; Marcos, R; Suárez, S; Velázquez, A; Xamena, N	1
Shelby, MD; Tindall, KR	1
Ashby, J; Gorelick, NJ; Shelby, MD	1
Burlinson, B; Mattison, JD; Penrose, LB	1
Carr, G; Dycaico, MJ; Provost, GS; Rogers, BJ	1
Carr, GJ; Putman, DL; Ritter, AP; Young, RR	1
Brault, D; Renault, D; Thybaud, V	1
Hayashi, M; Itoh, S; Miura, M; Shimada, H; Sofuni, T; Suzuki, T; Takemoto, N; Yajima, N	1
Baan, RA; Bergmans, A; van Delft, JH	1
Carr, G; Mirsalis, JC; Winegar, RA	1
Ashby, J; Lefevre, P; Tinwell, H; Williams, CV	1
Aardema, MJ; Andrews, JL; Carr, GJ; Gibson, DP; Gorelick, NJ	1
Douglas, GR; Gingerich, JD; Jiao, J; Soper, LM	1
Liegibel, UM; Schmezer, P	1
Brooks, TM; Dean, SW	1
Brooks, T; Carr, GJ; Douglas, GR; Gorelick, NJ; Liegibel, UM; Lockhart, AC; Margolin, BH; Piegorsch, WW; Suzuki, T; Thybaud, V; van Delft, JH	1
Angel, P; Bender, K; Knebel, A; Wilhelm, D	1
Cabré, O; Marcos, R; Soriano, S; Velázquez, A; Xamena, N	1
Bailey, JA; Cooper, DP; Deans, B; Elder, RH; Heeran, MC; Jansen, JG; Margison, GP; Mynett, KJ; Rafferty, JA; van Zeeland, AA; Watson, AJ; Weeks, RJ; Wijnhoven, SW; Willington, MA	1
Gichner, T; Plewa, MJ; Ptácek, O; Stavreva, DA	1
Hara, T; Kawakami, K; Nohmi, T; Shibuya, T; Sofuni, T; Sui, H; Suzuki, M; Yamada, M	1
Brozmanová, J; Chovanec, M; Farkasová, E; Margison, GP; Vlasáková, D; Vlcková, V	1
Arceo, C; Olvera, O; Zimmering, S	1
Creus, A; Kaya, B; Marcos, R; Velázquez, A; Yanikoğlu, A	1
Cabré, O; Marcos, R; Suárez, S; Velázquez, A; Xamena, N	1
Bremer, S; Domke, A; Tenschert, B; Vogel, R	1
Kaneko, H; Odawara, K; Yamada, T	1
Elsner, M; Guldbakke, B; Lenzen, S; Munday, R; Tiedge, M	1
Harbach, PR; Swenson, DH; Trzos, RJ	1
Bilbao, C; Comendador, MA; Ferreiro, JA; Sierra, LM	1
Chowdhuri, DK; Dhawan, A; Saxena, DK; Siddique, HR	1
Martin, EA; O'Donovan, MR; Smith, CC	1
Doak, SH; Jenkins, GJ; Johnson, GE; Parry, EM; Parry, JM; Quick, E	1
Stang, A; Witte, I	1
Donovan, P; Smith, G	1
Kuehner, S; Linsenmeyer, R; Schütz, P; Speit, G	1
Carr, GJ; Corvi, R; Downs, TR; Krul, CA; Pfuhler, S; Reisinger, K; Reus, AA; Zeller, A	1
Abraham, L; Bodger, OG; Dearfield, KL; Gollapudi, BB; Heflich, RH; Hixon, JG; Johnson, GE; Lovell, DP; MacGregor, JT; Pottenger, LH; Soeteman-Hernández, LG; Tanir, JY; Thompson, CM; Thybaud, V; van Benthem, J; White, PA; Zeiger, E	1
Anderson, D; Brinkworth, MH; Habas, K	1

Reviews

4 review(s) available for ethylnitrosourea and methyl methanesulfonate

Article	Year
The role of O-6 methylguanine DNA methyltransferase (MGMT) in drug resistance and strategies for its inhibition. Seminars in cancer biology, 1991, Volume: 2, Issue:4 Topics: Animals; DNA Repair; Drug Resistance; Ethylnitrosourea; Guanine; Humans; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methyltransferases; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Rats; Streptozocin	1991
Mammalian germ cell mutagenicity of ENU, IPMS and MMS, chemicals selected for a transgenic mouse collaborative study. Mutation research, 1997, Feb-14, Volume: 388, Issue:2-3 Topics: Animals; Ethylnitrosourea; Germ-Line Mutation; Male; Mesylates; Methyl Methanesulfonate; Mice; Mice, Transgenic; Mutagenicity Tests; Mutagens	1997
Mutation assays in male germ cells from transgenic mice: overview of study and conclusions. Mutation research, 1997, Feb-14, Volume: 388, Issue:2-3 Topics: Animals; Ethylnitrosourea; Germ-Line Mutation; Male; Mesylates; Methyl Methanesulfonate; Mice; Mice, Transgenic; Mutagenicity Tests; Mutagens	1997
Influence of mus201 and mus308 mutations of Drosophila melanogaster on the genotoxicity of model chemicals in somatic cells in vivo measured with the comet assay. Mutation research, 2002, Jun-19, Volume: 503, Issue:1-2 Topics: Animals; Comet Assay; DNA Damage; DNA Polymerase I; DNA Repair; DNA Repair Enzymes; DNA-Binding Proteins; DNA-Directed DNA Polymerase; Drosophila melanogaster; Drosophila Proteins; Endonucleases; Ethyl Methanesulfonate; Ethylnitrosourea; Hydrogen-Ion Concentration; Methyl Methanesulfonate; Mutagens; Nuclear Proteins; Transcription Factors	2002

Other Studies

77 other study(ies) available for ethylnitrosourea and methyl methanesulfonate

Article	Year
DNA repair synthesis in rat retinal ganglion cells treated with chemical carcinogens or ultraviolet light in vitro, with special reference to aging and repair level. Journal of the National Cancer Institute, 1978, Volume: 61, Issue:4 Topics: 4-Nitroquinoline-1-oxide; Age Factors; Animals; Carcinogens; DNA; DNA Repair; Ethylnitrosourea; Ganglia; Male; Methyl Methanesulfonate; Rats; Retina; Ultraviolet Rays	1978
Carcinogen-induced DNA repair in nucleotide-permeable Escherichia coli cells. Induction of DNA repair by the carcinogens methyl and ethyl nitrosourea and methyl methanesulfonate. European journal of biochemistry, 1975, Aug-15, Volume: 56, Issue:2 Topics: Carcinogens; DNA Nucleotidyltransferases; DNA Repair; DNA Replication; Escherichia coli; Ethylnitrosourea; Mesylates; Methyl Methanesulfonate; Methylnitrosourea; Mitomycins; Nitrosourea Compounds; Nucleotides; Permeability; Radiation Effects; Ultraviolet Rays	1975
An assay for phosphotriester formation in the reaction of alkylating agents with deoxyribosenucleic acid in vitro and in vivo. Chemico-biological interactions, 1976, Volume: 13, Issue:3-4 Topics: Animals; Coliphages; DNA, Viral; Ethyl Methanesulfonate; Ethylnitrosourea; Liver; Mathematics; Mesylates; Methyl Methanesulfonate; Methylnitrosourea; Mice; Molecular Weight; Nitrosourea Compounds; Sulfuric Acids	1976
Validation studies with the micronucleus test for early spermatids of rats. A tool for detecting clastogenicity of chemicals in differentiating spermatogonia and spermatocytes. Mutagenesis, 1992, Volume: 7, Issue:6 Topics: Animals; Cyclophosphamide; Ethylnitrosourea; Evaluation Studies as Topic; Male; Methyl Methanesulfonate; Mice; Micronucleus Tests; Mitomycin; Mutagens; Rats; Rats, Wistar; Spermatids; Spermatocytes; Spermatogonia; Vincristine	1992
Base alterations in yeast induced by alkylating agents with differing Swain-Scott substrate constants. Journal of molecular biology, 1992, Feb-05, Volume: 223, Issue:3 Topics: Alkylating Agents; Base Sequence; DNA Mutational Analysis; DNA, Fungal; Ethyl Methanesulfonate; Ethylnitrosourea; Gene Amplification; Methyl Methanesulfonate; Methylnitrosourea; Mutagens; Saccharomyces cerevisiae	1992
Sequence-selective depurination, DNA interstrand cross-linking and DNA strand break formation associated with alkylated DNA. Carcinogenesis, 1992, Volume: 13, Issue:3 Topics: Alkylation; Base Sequence; Cross-Linking Reagents; DNA; DNA Damage; Ellagic Acid; Ethylnitrosourea; Guanine; Methyl Methanesulfonate; Molecular Sequence Data; Spermidine	1992
Molecular analysis of mutations induced in the vermilion gene of Drosophila melanogaster by methyl methanesulfonate. Genetics, 1992, Volume: 131, Issue:3 Topics: Animals; Base Sequence; Chromosome Deletion; Crosses, Genetic; DNA Mutational Analysis; Drosophila melanogaster; Ethylnitrosourea; Female; Genes, Lethal; Male; Methyl Methanesulfonate; Molecular Sequence Data; Mutagens; Mutation; Reproduction; Spermatozoa; Time Factors	1992
Inhibition of O6-alkylguanine-DNA alkyltransferase and DNase I activities in vitro by some alkylating substances and antineoplastic agents. Journal of cancer research and clinical oncology, 1991, Volume: 117, Issue:6 Topics: Alkylating Agents; Animals; Antineoplastic Agents; Bisbenzimidazole; Bleomycin; Brain; Chick Embryo; Deoxyribonucleases; DNA Repair; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Doxorubicin; Ethidium; Ethyl Methanesulfonate; Ethylnitrosourea; Hot Temperature; In Vitro Techniques; Liver; Methyl Methanesulfonate; Methylnitrosourea; Methyltransferases; Novobiocin; O(6)-Methylguanine-DNA Methyltransferase; Substrate Specificity; Suramin; X-Rays	1991
Chemical induction of somatic gene mutations and chromosomal aberrations in lung fibroblasts of rats. Mutation research, 1991, Volume: 263, Issue:4 Topics: Animals; Cells, Cultured; Chromosome Aberrations; Dose-Response Relationship, Drug; Ethylnitrosourea; Fibroblasts; Lung; Male; Methyl Methanesulfonate; Micronucleus Tests; Mutagenicity Tests; Mutation; Rats; Rats, Inbred F344	1991
Alkylating agent hypersensitivity in poly(adenosine diphosphate-ribose) polymerase deficient cell lines. Cancer communications, 1991, Volume: 3, Issue:3 Topics: 4-Nitroquinoline-1-oxide; Alkylating Agents; Animals; Cell Line; Cell Survival; Cricetinae; DNA Repair; Dose-Response Relationship, Drug; Ethyl Methanesulfonate; Ethylnitrosourea; Lethal Dose 50; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Poly(ADP-ribose) Polymerases; Sulfuric Acid Esters	1991
Inhibitor of poly(ADP-ribose)transferase potentiates the recombinogenic but not the mutagenic action of alkylating agents in somatic cells in vivo in Drosophila melanogaster. Mutagenesis, 1990, Volume: 5, Issue:5 Topics: Alkylating Agents; Animals; Benzamides; Dose-Response Relationship, Drug; Drosophila melanogaster; Ethylnitrosourea; Heterozygote; Methyl Methanesulfonate; Mutation; Phenotype; Poly(ADP-ribose) Polymerase Inhibitors; Recombination, Genetic	1990
Preventive action of thioethers towards in vitro DNA binding and mutagenesis in E. coli K12 by alkylating agents. Mutation research, 1990, Volume: 245, Issue:2 Topics: Alkylating Agents; Benzoates; DNA; Escherichia coli; Ethyl Methanesulfonate; Ethylnitrosourea; Methyl Methanesulfonate; Methylnitrosourea; Mutagenicity Tests; Sulfides	1990
The ratio of induced recessive lethals to ring-X loss has prognostic value in terms of functionality of chemical mutagens in Drosophila melanogaster. Mutation research, 1988, Volume: 201, Issue:1 Topics: Alkylating Agents; Animals; Chromosome Aberrations; Cisplatin; Cross-Linking Reagents; DNA Damage; Drosophila melanogaster; Ethylnitrosourea; Genes, Lethal; Male; Methyl Methanesulfonate; Mutagenicity Tests; Mutagens; Ring Chromosomes; Triethylenephosphoramide	1988
In vitro developmental toxicity of five direct-acting alkylating agents in rodent embryos: structure-activity patterns. Teratology, 1989, Volume: 40, Issue:3 Topics: Alkylating Agents; Analysis of Variance; Animals; Brain; Dose-Response Relationship, Drug; Embryo, Mammalian; Ethyl Methanesulfonate; Ethylnitrosourea; Female; In Vitro Techniques; Maternal-Fetal Exchange; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Pregnancy; Rats; Rats, Inbred Strains	1989
The role of short-lived lesions in the induction of micronuclei in rat liver by ethylnitrosourea and methyl methanesulphonate: the importance of experimental design. Mutation research, 1989, Volume: 210, Issue:2 Topics: Animals; Bone Marrow; Dose-Response Relationship, Drug; Ethylnitrosourea; Liver; Liver Regeneration; Male; Methyl Methanesulfonate; Micronucleus Tests; Rats; Time Factors	1989
Inactivation of purified human O6-alkylguanine-DNA alkyltransferase by alkylating agents or alkylated DNA. Cancer research, 1986, Volume: 46, Issue:5 Topics: Alkylating Agents; DNA; Dose-Response Relationship, Drug; Ethylnitrosourea; Humans; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Streptozocin; Sulfuric Acid Esters	1986
Potentiation of cytotoxicity by 3-aminobenzamide in DNA repair-deficient human tumor cell lines following exposure to methylating agents or anti-neoplastic drugs. Carcinogenesis, 1988, Volume: 9, Issue:4 Topics: Antineoplastic Agents; Benzamides; Busulfan; Cell Line; Cell Survival; DNA Repair; Drug Synergism; Ethylnitrosourea; Humans; Kinetics; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; Tumor Cells, Cultured; Tumor Stem Cell Assay	1988
Cell killing by various monofunctional alkylating agents in Chinese hamster ovary cells. Mutation research, 1987, Volume: 177, Issue:2 Topics: Alkylating Agents; Animals; Caffeine; Cell Cycle; Cell Line; Cell Survival; Colony-Forming Units Assay; Cricetinae; Cricetulus; Ethylnitrosourea; Female; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Ovary	1987
Persistence of preclastogenic damage in hepatocytes of rats exposed to ethylnitrosourea, diethylnitrosamine, dimethylnitrosamine and methyl methanesulphonate. Correlation with DNA O-alkylation. Carcinogenesis, 1986, Volume: 7, Issue:7 Topics: Alkylation; Animals; Diethylnitrosamine; Dimethylnitrosamine; DNA; Ethylnitrosourea; Hepatectomy; Liver; Male; Methyl Methanesulfonate; Rats; Rats, Inbred Strains; Time Factors	1986
Spontaneous and induced sister-chromatid exchanges in cultured mosquito cells. Cytobios, 1986, Volume: 46, Issue:186-187 Topics: Aedes; Animals; Bromodeoxyuridine; Cell Line; Dose-Response Relationship, Drug; Ethyl Methanesulfonate; Ethylnitrosourea; Methyl Methanesulfonate; Methylnitrosourea; Mutagens; Sister Chromatid Exchange; Species Specificity	1986
Differential capacities for DNA repair in Clara cells, alveolar type II cells and macrophages of rabbit lung. Carcinogenesis, 1985, Volume: 6, Issue:4 Topics: Animals; Carcinogens; Cells, Cultured; DNA Repair; Ethylnitrosourea; Lung; Macrophages; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Pulmonary Alveoli; Rabbits	1985
The effect of two chemical mutagens ENU and MMS on MR-mediated reversion of an insertion-sequence mutation in Drosophila melanogaster. Mutation research, 1983, Volume: 110, Issue:2 Topics: Animals; DNA Transposable Elements; Drosophila melanogaster; Ethylnitrosourea; Female; Genes, Lethal; Male; Methyl Methanesulfonate; Mutagenicity Tests; Mutation; Nitrosourea Compounds; Recombination, Genetic	1983
Alkaline elution of rat testicular DNA: detection of DNA strand breaks after in vivo treatment with chemical mutagens. Mutation research, 1984, Volume: 130, Issue:4 Topics: Animals; Dimethyl Sulfoxide; DNA, Single-Stranded; Edetic Acid; Ethyl Methanesulfonate; Ethylnitrosourea; Hydrogen-Ion Concentration; Male; Methyl Methanesulfonate; Methylnitrosourea; Mutagens; Phenols; Polyethylene Glycols; Rats; Testis; Time Factors	1984
Relationship between cell killing, chromosomal aberrations, sister-chromatid exchanges and point mutations induced by monofunctional alkylating agents in Chinese hamster cells. A correlation with different ethylation products in DNA. Mutation research, 1984, Volume: 128, Issue:1 Topics: Alkylating Agents; Animals; Cell Survival; Cells, Cultured; Chromosome Aberrations; Cricetinae; Crossing Over, Genetic; Dose-Response Relationship, Drug; Ethyl Methanesulfonate; Ethylnitrosourea; Female; Methyl Methanesulfonate; Methylnitrosourea; Mutation; Sister Chromatid Exchange; Sulfuric Acid Esters	1984
Inhibition of protein A24 lyase by nitrosoureas. FEBS letters, 1984, Oct-29, Volume: 176, Issue:2 Topics: Animals; Carcinoma, Ehrlich Tumor; Carmustine; Cyanates; Ethyl Methanesulfonate; Ethylnitrosourea; Histones; Isocyanates; Lyases; Methyl Methanesulfonate; Methylnitrosourea; Nitrosourea Compounds; Ubiquitins	1984
Cross-resistance studies with V79 Chinese hamster cells adapted to the mutagenic or clastogenic effect of N-methyl-N'-nitro-N-nitrosoguanidine. Mutation research, 1983, Volume: 111, Issue:3 Topics: Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; Drug Resistance; Ethyl Methanesulfonate; Ethylnitrosourea; Lung; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagens; Thioguanine; Ultraviolet Rays	1983
Reduction of sister chromatid exchange frequency with time after mutagen exposure in Chinese hamster ovary cells in the presence of 3-aminobenzamide. Environmental mutagenesis, 1984, Volume: 6, Issue:2 Topics: Animals; Benzamides; Bromodeoxyuridine; Cell Line; Cricetinae; Cricetulus; Crossing Over, Genetic; DNA Repair; Drug Interactions; Ethylnitrosourea; Methyl Methanesulfonate; Mutagenicity Tests; Mutagens; Nitrosourea Compounds; Sister Chromatid Exchange; Time Factors	1984
Autoradiographic demonstration of DNA repair synthesis in rat tracheal epithelium treated with chemical carcinogen in vitro. Cancer research, 1980, Volume: 40, Issue:8 Pt 1 Topics: 4-Nitroquinoline-1-oxide; Animals; Autoradiography; Carcinogens; DNA Repair; Dose-Response Relationship, Drug; Epithelium; Ethylnitrosourea; Male; Methyl Methanesulfonate; Rats; Stimulation, Chemical; Trachea	1980
[Drosophila mutants sensitive to methylmethane sulfonate. I. Their isolation and genetic analysis]. Nauchnye doklady vysshei shkoly. Biologicheskie nauki, 1981, Issue:11 Topics: Animals; Chromosomes; Drosophila melanogaster; Drug Resistance; Ethyl Methanesulfonate; Ethylnitrosourea; Female; Larva; Male; Methyl Methanesulfonate; Mutation	1981
[Para-aminobenzoic acid intensification of DNA repair processes in Escherichia coli K-12]. Genetika, 1982, Volume: 18, Issue:3 Topics: 4-Aminobenzoic Acid; Aminobenzoates; DNA Repair; DNA, Bacterial; Drug Interactions; Escherichia coli; Ethyl Methanesulfonate; Ethylnitrosourea; Methyl Methanesulfonate; Methylnitrosourea; Stimulation, Chemical	1982
Relationship between chemical damage of DNA and mutations in mammalian cells. I. Dose-response curves for the induction of 6-thioguanine-resistant mutants by low doses of monofunctional alkylating agents, X-rays and UV radiation in V79 Chinese hamster cel Mutation research, 1980, Volume: 73, Issue:2 Topics: Animals; Cell Line; Cricetinae; Cricetulus; DNA; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Ethyl Methanesulfonate; Ethylnitrosourea; Lung; Methyl Methanesulfonate; Methylnitrosourea; Mutation; Ultraviolet Rays; X-Rays	1980
Methodological aspects of the white-ivory assay of Drosophila melanogaster. Mutation research, 1995, Volume: 335, Issue:2 Topics: Alkylating Agents; Animals; Cross-Linking Reagents; Drosophila melanogaster; Ethyl Methanesulfonate; Ethylnitrosourea; Evaluation Studies as Topic; Eye Color; Female; Hempa; Male; Methyl Methanesulfonate; Multigene Family; Mutagenicity Tests; Mutagens; Sex Characteristics; Species Specificity	1995
Toxicity of four alkylating agents on in vitro rat embryo differentiation and development. Fundamental and applied toxicology : official journal of the Society of Toxicology, 1995, Volume: 26, Issue:1 Topics: Abnormalities, Drug-Induced; Animals; Cell Differentiation; Cells, Cultured; Central Nervous System; Dose-Response Relationship, Drug; Embryonic and Fetal Development; Ethyl Methanesulfonate; Ethylnitrosourea; Female; Forelimb; Methyl Methanesulfonate; Methylnitrosourea; Rats	1995
Somatic reversion of some copia-like induced mutations, at the white locus of Drosophila melanogaster, after treatment with alkylating agents. Environmental and molecular mutagenesis, 1995, Volume: 25, Issue:2 Topics: Alkylating Agents; Animals; DNA Transposable Elements; Drosophila melanogaster; Ethyl Methanesulfonate; Ethylnitrosourea; Eye Color; Male; Methyl Methanesulfonate; Mutagenesis, Insertional; Mutagenesis, Site-Directed; Mutagenicity Tests; Suppression, Genetic	1995
The hypermutability conferred by the mus308 mutation of Drosophila is not specific for cross-linking agents. Mutation research, 1995, Volume: 336, Issue:3 Topics: Alkylating Agents; Altretamine; Animals; Cross-Linking Reagents; DNA Adducts; DNA Damage; DNA Repair; Drosophila melanogaster; Ethylnitrosourea; Female; Genes, Insect; Genes, Lethal; Hempa; Male; Methyl Methanesulfonate; Models, Genetic; Mutagenesis	1995
The accumulation and persistence of somatic mutations in vivo. Mutagenesis, 1994, Volume: 9, Issue:3 Topics: 1,2-Dimethylhydrazine; Animals; Dimethylhydrazines; Ethylnitrosourea; Female; Intestine, Small; Lac Operon; Male; Methyl Methanesulfonate; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutagenesis; Mutagenicity Tests; Mutation; Time Factors	1994
Comparison of effects of direct-acting DNA methylating and ethylating agents on inducible gene expression in vivo. Environmental and molecular mutagenesis, 1994, Volume: 23, Issue:3 Topics: Alkylating Agents; Animals; Carcinogens; Chick Embryo; DNA; DNA Damage; Enzyme Induction; Ethyl Methanesulfonate; Ethylnitrosourea; Genes; Methyl Methanesulfonate; Methylation; Methylnitrosourea; Mutagenesis, Site-Directed; Phosphoenolpyruvate Carboxykinase (GTP)	1994
Studies on DNA repair defects in degenerative brain disease. Age and ageing, 1993, Volume: 22, Issue:1 Topics: Adult; Aged; Alzheimer Disease; Cells, Cultured; DNA Damage; DNA Repair; Ethylnitrosourea; Female; Gamma Rays; Humans; Huntington Disease; Lymphocytes; Male; Methyl Methanesulfonate; Middle Aged; Parkinson Disease	1993
Comparison of inhibition of glucose-stimulated insulin secretion in rat islets of Langerhans by streptozotocin and methyl and ethyl nitrosoureas and methanesulphonates. Lack of correlation with nitric oxide-releasing or O6-alkylating ability. Biochemical pharmacology, 1995, Dec-22, Volume: 50, Issue:12 Topics: Alkylating Agents; Animals; Cyclic GMP; Ethyl Methanesulfonate; Ethylnitrosourea; Glucose; Guanine; Insulin; Islets of Langerhans; Methyl Methanesulfonate; Methylnitrosourea; Nitric Oxide; Rats; Rats, Sprague-Dawley; Streptozocin; Structure-Activity Relationship	1995
Molecular study of the germinal reversions induced at the white-ivory locus in Drosophila melanogaster. Mutagenesis, 1996, Volume: 11, Issue:6 Topics: Alkylating Agents; Animals; Blotting, Southern; Drosophila melanogaster; Ethyl Methanesulfonate; Ethylnitrosourea; Eye Color; Germ-Line Mutation; Methyl Methanesulfonate; Mutagenicity Tests; Phenotype; Polymerase Chain Reaction	1996
Preliminary results of ethylnitrosourea, isopropyl methanesulphonate and methyl methanesulphonate activity in the testis and epididymal spermatozoa of Muta Mice. Mutation research, 1997, Feb-14, Volume: 388, Issue:2-3 Topics: Animals; Epididymis; Ethylnitrosourea; Male; Mesylates; Methyl Methanesulfonate; Mice; Mice, Transgenic; Mutagenicity Tests; Mutagens; Spermatozoa; Testis	1997
Evaluation of the transgenic Lambda/LacI mouse model as a short-term predictor of heritable risk. Mutation research, 1997, Feb-14, Volume: 388, Issue:2-3 Topics: Animals; Bacterial Proteins; Epididymis; Escherichia coli Proteins; Ethylnitrosourea; Evaluation Studies as Topic; Germ-Line Mutation; Lac Repressors; Male; Mesylates; Methyl Methanesulfonate; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutagenicity Tests; Repressor Proteins; Seminiferous Tubules; Spermatozoa; Transgenes	1997
Evaluation of spontaneous and chemical-induced lacI mutations in germ cells from lambda/lacI transgenic mice. Mutation research, 1997, Feb-14, Volume: 388, Issue:2-3 Topics: Animals; Bacterial Proteins; Escherichia coli Proteins; Ethylnitrosourea; Germ-Line Mutation; Lac Repressors; Male; Mesylates; Methyl Methanesulfonate; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutagenicity Tests; Mutagens; Repressor Proteins; Species Specificity; Spermatozoa	1997
Effect of ethylnitrosourea and methyl methanesulfonate on mutation frequency in Muta Mouse germ cells (seminiferous tubule cells and epididymis spermatozoa). Mutation research, 1997, Feb-14, Volume: 388, Issue:2-3 Topics: Animals; Bacteriophage lambda; Bone Marrow Cells; Epididymis; Ethylnitrosourea; Lac Operon; Male; Methyl Methanesulfonate; Mice; Mutagenicity Tests; Mutagens; Seminiferous Tubules; Spermatozoa	1997
Ethyl nitrosourea and methyl methanesulfonate mutagenicity in sperm and testicular germ cells of lacZ transgenic mice (Muta Mouse). Mutation research, 1997, Feb-14, Volume: 388, Issue:2-3 Topics: Animals; DNA; Ethylnitrosourea; Evaluation Studies as Topic; In Vitro Techniques; Lac Operon; Male; Methyl Methanesulfonate; Mice; Mice, Transgenic; Micronucleus Tests; Mutagenicity Tests; Mutagens; Spermatozoa; Testis	1997
Germ-cell mutagenesis in lambda lacZ transgenic mice treated with ethylating and methylating agents: comparison with specific-locus test. Mutation research, 1997, Feb-14, Volume: 388, Issue:2-3 Topics: Animals; Bacteriophage lambda; Epididymis; Ethyl Methanesulfonate; Ethylnitrosourea; Lac Operon; Male; Methyl Methanesulfonate; Methylnitrosourea; Mice; Mice, Transgenic; Mutagenesis; Mutagenicity Tests; Mutagens; Spermatozoa; Vas Deferens	1997
Analysis of the mutagenic potential of ENU and MMS in germ cells of male C57BL/6 lacI transgenic mice. Mutation research, 1997, Feb-14, Volume: 388, Issue:2-3 Topics: Animals; DNA; Ethylnitrosourea; Male; Methyl Methanesulfonate; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutagenicity Tests; Mutagens; Seminiferous Tubules; Spermatozoa	1997
The activity of ENU, iPMS and MMS in male mouse germ cells using the Muta Mouse positive selection transgenic mutation assay. Mutation research, 1997, Feb-14, Volume: 388, Issue:2-3 Topics: Animals; DNA; Epididymis; Ethylnitrosourea; Female; Male; Mesylates; Methyl Methanesulfonate; Mice; Mice, Inbred CBA; Mice, Transgenic; Mutagenicity Tests; Mutagens; Oligospermia; Ovum; Pregnancy; Sperm Count; Spermatozoa; Testis	1997
Evaluation of lacI mutation in germ cells and micronuclei in peripheral blood after treatment of male lacI transgenic mice with ethylnitrosourea, isopropylmethane sulfonate or methylmethane sulfonate. Mutation research, 1997, Feb-14, Volume: 388, Issue:2-3 Topics: Animals; Bacterial Proteins; Epididymis; Escherichia coli Proteins; Ethylnitrosourea; Lac Repressors; Male; Mesylates; Methyl Methanesulfonate; Mice; Mice, Inbred C57BL; Mice, Transgenic; Micronucleus Tests; Mutagenicity Tests; Mutagens; Repressor Proteins; Seminiferous Tubules; Spermatozoa	1997
Toward an understanding of the use of transgenic mice for the detection of gene mutations in germ cells. Mutation research, 1997, Feb-14, Volume: 388, Issue:2-3 Topics: Animals; Epididymis; Ethylnitrosourea; Lac Operon; Male; Mesylates; Methyl Methanesulfonate; Mice; Mice, Transgenic; Mutagenicity Tests; Mutagens; Seminiferous Tubules; Spermatozoa	1997
Detection of the two germ cell mutagens ENU and iPMS using the LacZ/transgenic mouse mutation assay. Mutation research, 1997, Feb-14, Volume: 388, Issue:2-3 Topics: Animals; Body Weight; Ethylnitrosourea; Lac Operon; Male; Mesylates; Methyl Methanesulfonate; Mice; Mice, Transgenic; Mutagenicity Tests; Mutagens; Organ Size; Spermatozoa; Testis	1997
The detection of gene mutation in the tubular sperm of Muta Mice following a single intraperitoneal treatment with methyl methanesulphonate or ethylnitrosourea. Mutation research, 1997, Feb-14, Volume: 388, Issue:2-3 Topics: Animals; DNA; Escherichia coli; Ethylnitrosourea; Injections, Intraperitoneal; Male; Methyl Methanesulfonate; Mice; Mice, Transgenic; Mutagenicity Tests; Mutagens; Seminiferous Tubules; Spermatozoa	1997
Sources of variability in data from a positive selection lacZ transgenic mouse mutation assay: an interlaboratory study. Mutation research, 1997, Feb-14, Volume: 388, Issue:2-3 Topics: Animals; Data Interpretation, Statistical; Ethyl Methanesulfonate; Ethylnitrosourea; International Cooperation; Laboratories; Lac Operon; Male; Mesylates; Methyl Methanesulfonate; Methylnitrosourea; Mice; Mice, Transgenic; Mutagenicity Tests; Mutagens; Spermatozoa	1997
The level of intracellular glutathione is a key regulator for the induction of stress-activated signal transduction pathways including Jun N-terminal protein kinases and p38 kinase by alkylating agents. Molecular and cellular biology, 1997, Volume: 17, Issue:8 Topics: Acetylcysteine; Alkylating Agents; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Activation; Enzyme Inhibitors; Ethylnitrosourea; Genes, jun; Glutamate-Cysteine Ligase; Glutathione; Humans; JNK Mitogen-Activated Protein Kinases; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oxidation-Reduction; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Poly(ADP-ribose) Polymerase Inhibitors; Receptors, Cell Surface; Reducing Agents; Signal Transduction; Ultraviolet Rays	1997
Induced somatic and germinal reversion of the white-spotted-1 insertional mutant phenotype in Drosophila melanogaster. Mutagenesis, 1998, Volume: 13, Issue:2 Topics: Animals; ATP-Binding Cassette Transporters; Drosophila melanogaster; Drosophila Proteins; Ethyl Methanesulfonate; Ethylnitrosourea; Eye Proteins; Female; Germ-Line Mutation; Insect Proteins; Larva; Male; Methyl Methanesulfonate; Mutagenesis, Insertional; Mutation; Phenotype; Retroelements	1998
Evaluation of P19 cells for studying mechanisms of developmental toxicity: application to four direct-acting alkylating agents. Toxicology, 1998, May-15, Volume: 127, Issue:1-3 Topics: Alkylating Agents; Aminobutyrates; Animals; Antineoplastic Agents, Alkylating; Carcinoma, Embryonal; Cell Differentiation; Cell Division; Dimethyl Sulfoxide; Ethyl Methanesulfonate; Ethylnitrosourea; gamma-Aminobutyric Acid; Male; Mesencephalon; Methyl Methanesulfonate; Methylnitrosourea; Mice; Neurons; Tretinoin; Tumor Cells, Cultured	1998
Effects of O6-benzylguanine on growth and differentiation of P19 embryonic carcinoma cells treated with alkylating agents. Teratogenesis, carcinogenesis, and mutagenesis, 1998, Volume: 18, Issue:3 Topics: Alkylating Agents; Animals; Antineoplastic Agents; Carcinogens; Carcinoma, Embryonal; Cell Differentiation; Cell Division; Cell Survival; DNA Repair; Ethyl Methanesulfonate; Ethylnitrosourea; Guanine; Mesencephalon; Methyl Methanesulfonate; Methylnitrosourea; Mice; Neurons; O(6)-Methylguanine-DNA Methyltransferase; Rats; Tretinoin; Tumor Cells, Cultured	1998
Alkylpurine-DNA-N-glycosylase knockout mice show increased susceptibility to induction of mutations by methyl methanesulfonate. Molecular and cellular biology, 1998, Volume: 18, Issue:10 Topics: Animals; Bone Marrow Cells; Cells, Cultured; Dacarbazine; DNA Glycosylases; Erythrocytes; Ethylnitrosourea; Female; Fibroblasts; Guanine; Hypoxanthine Phosphoribosyltransferase; Leukocyte Count; Liver; Male; Methyl Methanesulfonate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Mutagens; Mutation; N-Glycosyl Hydrolases; Temozolomide	1998
Comparison of DNA damage in plants as measured by single cell gel electrophoresis and somatic leaf mutations induced by monofunctional alkylating agents. Environmental and molecular mutagenesis, 1999, Volume: 33, Issue:4 Topics: Alkylating Agents; DNA Damage; DNA, Plant; Electrophoresis; Environmental Monitoring; Ethyl Methanesulfonate; Ethylnitrosourea; Methyl Methanesulfonate; Methylnitrosourea; Mutagens; Nicotiana; Nucleic Acid Conformation; Plant Leaves; Plant Roots; Plants, Toxic	1999
Effects of O (6)-alkylguanine-DNA alkyltransferase deficiency in Escherichia coli as the host for the detection of mutations in lacI transgenic mice. Environmental and molecular mutagenesis, 1999, Volume: 34, Issue:2-3 Topics: Animals; Bacterial Proteins; Bacteriophage lambda; Escherichia coli; Escherichia coli Proteins; Ethylnitrosourea; Lac Repressors; Male; Methyl Methanesulfonate; Mice; Mice, Transgenic; Mutagens; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Repressor Proteins; Spermatozoa	1999
Effect of stable integration of the Escherichia coli ada gene on the sensitivity of Saccharomyces cerevisiae to the toxic and mutagenic effects of alkylating agents. Environmental and molecular mutagenesis, 2000, Volume: 35, Issue:1 Topics: Alkylating Agents; Bacterial Proteins; Escherichia coli; Escherichia coli Proteins; Ethylnitrosourea; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutagens; O(6)-Methylguanine-DNA Methyltransferase; Saccharomyces cerevisiae; Transcription Factors	2000
Chlorophyllin [CHLN] and the mutagenicity of monofunctional alkylating agents in Drosophila: the action of CHLN need not include an influence on metabolic activation. Mutation research, 2000, May-08, Volume: 467, Issue:2 Topics: Alkylating Agents; Animals; Antimutagenic Agents; Chlorophyllides; Diethylnitrosamine; Dose-Response Relationship, Drug; Drosophila; Ethylnitrosourea; Female; Male; Methyl Methanesulfonate; Methylnitrosourea; Mutagenesis; Mutagenicity Tests; Wings, Animal	2000
Induction of an adaptive response in Drosophila imaginal disc cells exposed in vivo to low doses of alkylating agents. Mutagenesis, 2000, Volume: 15, Issue:4 Topics: Alkylating Agents; Animals; Crosses, Genetic; Dose-Response Relationship, Drug; Drosophila; Ethyl Methanesulfonate; Ethylnitrosourea; Larva; Methyl Methanesulfonate; Mutagenicity Tests; Mutagens; Wings, Animal	2000
Sequence analysis of the boundaries of the tandem duplication from the white-ivory mutant of Drosophila melanogaster and two chemically induced revertants. Mutagenesis, 2000, Volume: 15, Issue:4 Topics: Alkylating Agents; Animals; Base Sequence; DNA; DNA Damage; DNA Mutational Analysis; DNA Repair; Drosophila melanogaster; Ethylnitrosourea; Gene Duplication; Methyl Methanesulfonate; Models, Genetic; Molecular Sequence Data; Mutagens; Polymerase Chain Reaction	2000
In vitro germ cell models for the detection of fertility impairment. Andrologia, 2000, Volume: 32, Issue:4-5 Topics: Animals; Cell Differentiation; Cell Division; DNA Damage; Drug Evaluation, Preclinical; Ethylnitrosourea; Fertility; Germ Cells; Methyl Methanesulfonate; Mice; Mitomycin; Models, Biological; Mutagens; Sister Chromatid Exchange; Stem Cells; Teratocarcinoma; Tumor Cells, Cultured	2000
Concurrent detection of gene mutations and chromosome aberrations induced by five chemicals in a CHL/IU cell line incorporating a gpt shuttle vector. Mutation research, 2000, Nov-20, Volume: 471, Issue:1-2 Topics: Animals; Bacterial Proteins; Cell Survival; Cells, Cultured; Chromosome Aberrations; Cricetinae; Cricetulus; Escherichia coli; Escherichia coli Proteins; Ethylnitrosourea; Genetic Vectors; Methyl Methanesulfonate; Mitomycin; Mutagenesis; Mutagens; Pentosyltransferases; Proteins; Rosaniline Dyes; Toluidines; Vincristine	2000
Relative importance of transport and alkylation for pancreatic beta-cell toxicity of streptozotocin. Diabetologia, 2000, Volume: 43, Issue:12 Topics: 3-O-Methylglucose; Alkylating Agents; Alkylation; Animals; Biological Transport; Biotransformation; Cell Line; Cell Survival; Ethyl Methanesulfonate; Ethylnitrosourea; Glucose Transporter Type 2; Islets of Langerhans; Kinetics; Methyl Methanesulfonate; Methylnitrosourea; Monosaccharide Transport Proteins; Rats; Recombinant Proteins; Streptozocin; Transfection	2000
The relationship between alkylation of specific DNA bases and induction of sister chromatid exchange. Carcinogenesis, 1980, Volume: 1, Issue:11 Topics: Alkylating Agents; Alkylation; Animals; Cell Line; Cricetinae; Cricetulus; DNA; DNA Methylation; Ethyl Methanesulfonate; Ethylnitrosourea; Methyl Methanesulfonate; Methylnitrosourea; Mutagens; Sister Chromatid Exchange	1980
Validation of Drosophila melanogaster as an in vivo model for genotoxicity assessment using modified alkaline Comet assay. Mutagenesis, 2005, Volume: 20, Issue:4 Topics: Alkylating Agents; Animals; Comet Assay; Cyclophosphamide; DNA Damage; Dose-Response Relationship, Drug; Drosophila melanogaster; Ethyl Methanesulfonate; Ethylnitrosourea; Larva; Methyl Methanesulfonate; Mutagenicity Tests; Mutagens; Sensitivity and Specificity	2005
hOGG1 recognizes oxidative damage using the comet assay with greater specificity than FPG or ENDOIII. Mutagenesis, 2006, Volume: 21, Issue:3 Topics: Animals; Bromates; Comet Assay; Deoxyribonuclease (Pyrimidine Dimer); Dimethyl Sulfoxide; DNA Damage; DNA Glycosylases; DNA Repair Enzymes; DNA-Formamidopyrimidine Glycosylase; Escherichia coli Proteins; Ethylnitrosourea; Gamma Rays; Guanine; Humans; Leukemia L5178; Methyl Methanesulfonate; Mice; Oxidation-Reduction; Sensitivity and Specificity	2006
Mechanistic influences for mutation induction curves after exposure to DNA-reactive carcinogens. Cancer research, 2007, Apr-15, Volume: 67, Issue:8 Topics: Alkylating Agents; Cell Line; Chromosome Aberrations; DNA; DNA Adducts; DNA Damage; Ethyl Methanesulfonate; Ethylnitrosourea; Humans; Hypoxanthine Phosphoribosyltransferase; Lymphocytes; Methyl Methanesulfonate; Methylnitrosourea; Mutagens; Point Mutation	2007
Performance of the comet assay in a high-throughput version. Mutation research, 2009, Apr-30, Volume: 675, Issue:1-2 Topics: 4-Nitroquinoline-1-oxide; Antineoplastic Agents; Cell Line; Cell Survival; Cisplatin; Comet Assay; DNA Damage; Dose-Response Relationship, Drug; Ethylnitrosourea; Fibroblasts; Humans; Methyl Methanesulfonate; Mutagens; Reproducibility of Results	2009
Mutagenicity of N-ethyl-N-nitrosourea, N-methyl-N-nitrosourea, methyl methanesulfonate and ethyl methanesulfonate in the developing Syrian hamster fetus. Mutation research, 2010, Jun-17, Volume: 699, Issue:1-2 Topics: Animals; Cricetinae; Ethyl Methanesulfonate; Ethylnitrosourea; Female; Fetus; Maternal-Fetal Exchange; Mesocricetus; Methyl Methanesulfonate; Methylnitrosourea; Mutagenicity Tests; Mutagens; Pregnancy; Pregnancy, Animal	2010
Insensitivity of the in vitro cytokinesis-block micronucleus assay with human lymphocytes for the detection of DNA damage present at the start of the cell culture. Mutagenesis, 2012, Volume: 27, Issue:6 Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Cell Culture Techniques; Cell Nucleus; Cells, Cultured; Comet Assay; Cytokinesis; DNA Damage; Epoxy Compounds; Ethyl Methanesulfonate; Ethylnitrosourea; Female; Humans; Lymphocytes; Male; Methyl Methanesulfonate; Micronucleus Tests; Mitomycin; Mutagenicity Tests; Mutagens	2012
Comet assay in reconstructed 3D human epidermal skin models--investigation of intra- and inter-laboratory reproducibility with coded chemicals. Mutagenesis, 2013, Volume: 28, Issue:6 Topics: 4-Nitroquinoline-1-oxide; Comet Assay; Cyclohexanones; DNA Damage; Drug Evaluation, Preclinical; Epidermis; Ethylnitrosourea; Humans; Laboratory Proficiency Testing; Methyl Methanesulfonate; Models, Biological; Mutagens; Nitrophenols; Phenylenediamines; Reproducibility of Results; Tissue Culture Techniques	2013
Derivation of point of departure (PoD) estimates in genetic toxicology studies and their potential applications in risk assessment. Environmental and molecular mutagenesis, 2014, Volume: 55, Issue:8 Topics: Animals; Benchmarking; Databases, Factual; Dose-Response Relationship, Drug; Ecotoxicology; Ethyl Methanesulfonate; Ethylnitrosourea; Humans; Methyl Methanesulfonate; Methylnitrosourea; Mutagens; No-Observed-Adverse-Effect Level; Risk Assessment	2014
In vitro responses to known in vivo genotoxic agents in mouse germ cells. Environmental and molecular mutagenesis, 2017, Volume: 58, Issue:2 Topics: Animals; Apoptosis; Cell Culture Techniques; Cell Survival; Cells, Cultured; Comet Assay; DNA Damage; Dose-Response Relationship, Drug; Ethylnitrosourea; Gene Expression; Male; Mercaptopurine; Methyl Methanesulfonate; Mice, Inbred Strains; Mutagens; Spermatozoa	2017