ethylnitrosourea has been researched along with guanine in 76 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 31 (40.79) | 18.7374 |
| 1990's | 38 (50.00) | 18.2507 |
| 2000's | 6 (7.89) | 29.6817 |
| 2010's | 1 (1.32) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lawley, PD; Warren, W | 2 |
| Magee, PN; Nicoll, JW; Pegg, AE; Swann, PF | 1 |
| Brent, TP; Gonzaga, PE; Ludlum, DB; Margison, GP; Niu, TQ; Potter, PM; Rafferty, JA; Yu, D | 1 |
| Gibson, NW; Prakash, AS | 1 |
| Bronstein, SM; Skopek, TR; Swenberg, JA | 1 |
| Kang, H; Maekawa, A; Nagase, S; Shumiya, S; Usuki, S | 1 |
| Bronstein, SM; Hooth, MJ; Skopek, TR; Swenberg, JA | 1 |
| Erickson, LC | 1 |
| Chen, FX; Church, KM; Gold, B; Wurdeman, RL; Zhang, Y | 1 |
| Eberle, G; Huh, NH; Nehls, P; Rajewsky, MF; Thomale, J | 1 |
| Den Engelse, L; Scherer, E; Van Den Berg, T; Vermeulen, E; Winterwerp, HH | 1 |
| Drinkwater, NR; Eckert, KA; Ingle, CA | 1 |
| Dolan, ME; Erickson, LC; Hora, NK; Pegg, AE | 1 |
| Nakabeppu, Y; Otsuka, M; Sekiguchi, M | 1 |
| Gibson, NW; Hartley, JA; Kohn, KW; Mattes, WB | 1 |
| Bresnick, E; Ding, R; Eastman, A; Ghosh, K | 1 |
| Rajewsky, MF; Samson, L; Thomale, J | 1 |
| Burns, PA; Glickman, BW; Gordon, AJ; Kunsmann, K | 1 |
| den Engelse, L; Jenner, AA; Scherer, E | 1 |
| Berger, J; Nehls, P; Rajewsky, MF; Spiess, E; Weber, E | 1 |
| Huh, N; Kuroki, T; Rajewsky, MF; Satoh, MS | 1 |
| Huh, NH; Rajewsky, MF | 1 |
| Kirk, MC; Ludlum, DB; Parker, S | 1 |
| Harbach, PR; Petzold, GL; Swenson, DH | 1 |
| Ehling, UH; Mohn, GR; Neuhäuser-Klaus, A; van Zeeland, AA | 1 |
| Babich, MA; Day, RS; Hurst-Calderone, S; Yarosh, DB | 1 |
| Huh, N; Rajewsky, MF | 1 |
| Nehls, P; Rajewsky, MF | 1 |
| Aida, T; Berger, MS; Bodell, WJ; Rosenblum, ML | 1 |
| Guttenplan, JB | 1 |
| Den Engelse, L; Kriek, E; Scherer, E; Westra, JG | 1 |
| Brent, TP | 1 |
| Renard, A; Verly, WG | 1 |
| Singer, B | 1 |
| Müller, R; Rajewsky, MF | 1 |
| Chang, MJ; Hart, RW; Koestner, A | 1 |
| Goth-Goldstein, R | 1 |
| Faustman, EM; Kidney, JK | 1 |
| Capucci, MS; De Groot, A; Hoffmann, ME; Natarajan, AT | 1 |
| Jansen, JG; Mohn, GR; Tates, AD; van Teijlingen, CM; van Zeeland, AA; Vrieling, H | 1 |
| Baeuerle, PA; Büning, H; Zorbas, H | 1 |
| Borotz, SE; Pfefferkorn, ER | 1 |
| Buschfort, C; Müller, MR; Rajewsky, MF; Seeber, S; Seiler, F; Thomale, J | 1 |
| Berger, SJ; Donovan, C; Gerson, SL; Varnes, ME | 1 |
| Cerutti, P; Pourzand, C | 1 |
| Anver, MR; Lijinsky, W; Moschel, RC; Pegg, AE | 1 |
| Hochleitner, K; Rajewsky, MF; Thomale, J | 1 |
| Bignami, M; Calcagnile, A; Di Muccio, A; Dogliotti, E; Fortini, P | 1 |
| Kirk, MC; Ludlum, DB; Niu, T; Yu, D | 1 |
| Fukuchi, M; Hitomi, K; Kohda, K; Kowada, M; Mineura, K; Terashima, I | 1 |
| Cunningham, JM; Delaney, CA; Di Matteo, M; Dunger, A; Green, IC; Green, MH | 1 |
| Baan, RA; Berends, F; Hochleitner, K; Lohman, PH; Luiten-Schuite, A; Mientjes, EJ; Rajewsky, MF; Thomale, J; van Delft, JH | 1 |
| Bodell, WJ; Ye, Q | 1 |
| Chambliss, GH; Kim, JH | 1 |
| Jansen, JG; Op het Veld, CW; van Hees-Stuivenberg, S; van Zeeland, AA | 1 |
| Baan, RA; Berends, F; Bergmans, A; Borsboom, Y; Lohman, PH; Luiten-Schuite, A; Mientjes, EJ; van Delft, JH; van der Wolf, E | 1 |
| Engelbergs, J; Galhoff, A; Rajewsky, MF; Thomale, J | 1 |
| Emura, M; Kamino, K; Mohr, U; Seiler, F; Thomale, J | 1 |
| Faustman, EM; Seeley, MR | 1 |
| Bailey, JA; Cooper, DP; Deans, B; Elder, RH; Heeran, MC; Jansen, JG; Margison, GP; Mynett, KJ; Rafferty, JA; van Zeeland, AA; Watson, AJ; Weeks, RJ; Wijnhoven, SW; Willington, MA | 1 |
| Buschfort, C; Lensing, C; Müller, MR; Rajewsky, MF; Seeber, S; Thomale, J | 1 |
| Brent, TP; Edwards, CC; Harris, LC; Houghton, PJ; Marathi, UK; Sorrentino, BP; Srivastava, DK; Vanin, EF | 1 |
| Bibby, MC; Margison, GP; McElhinney, RS; Rafferty, JA; Thompson, MJ | 1 |
| Branda, RF; Lafayette, AR; Nicklas, JA; O'Neill, JP | 1 |
| Gerson, SL; Phillips, WP | 1 |
| Erickson, LC; Kurpad, C; Maze, R; Pegg, AE; Williams, DA | 1 |
| de Zwart, FA; Magnusson, AL; Natarajan, AT; Nilsen, A; Nilsen, OG; Tates, AD; Törnqvist, M; van Dam, FJ; van Sittert, NJ; van Teylingen, CM; Zahlsen, K; Zwinderman, AH | 1 |
| Engelbergs, J; Rajewsky, MF; Schweer, T; Thomale, J | 1 |
| Den Engelse, L; Heyting, C; Huigen, A | 1 |
| Bodell, WJ; Dhananjaya, N; Giannini, DD; Miller, DL; Sprung, CN; Wang, YP | 1 |
| Alagramam, K; Davis, RR; Erway, LC; Pitts, D; Washington, JL; Wright, CG | 1 |
| Martin, EA; O'Donovan, MR; Smith, CC | 1 |
| Abbruzzese, JL; Chang, P; Firozi, PF; Jiao, L; Lai, D; Li, D | 1 |
| Bartleman, AP; Kirkland, JB; Kostecki, LM; Linford, G; Lizotte, M; Thomas, M; Toxopeus, L | 1 |
| Fan, T; Li, S; Sun, G; Zhao, L; Zhong, R | 1 |
2 review(s) available for ethylnitrosourea and guanine
| Article | Year |
|---|---|
The role of O-6 methylguanine DNA methyltransferase (MGMT) in drug resistance and strategies for its inhibition.
Topics: Animals; DNA Repair; Drug Resistance; Ethylnitrosourea; Guanine; Humans; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methyltransferases; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Rats; Streptozocin | 1991 |
Formation of DNA modifications by chemical carcinogens. Identification, localization and quantification.
Topics: Aflatoxin B1; Aflatoxins; Animals; Antibodies; Antibodies, Monoclonal; Benzo(a)pyrene; Blood-Brain Barrier; Blood-Testis Barrier; Carcinogens; Cyclophosphamide; DNA; DNA, Single-Stranded; Ethylnitrosourea; Female; Guanine; Histocytochemistry; Humans; Liver; Male; Nucleic Acid Conformation; Respiratory System; Spectrometry, Fluorescence; Tissue Distribution | 1984 |
74 other study(ies) available for ethylnitrosourea and guanine
| Article | Year |
|---|---|
Specific excision of ethylated purines from DNA of Escherichia coli treated with N-ethyl-N-nitrosourea.
Topics: Adenine; DNA Replication; DNA, Bacterial; Escherichia coli; Ethanol; Ethylnitrosourea; Guanine; Methylnitronitrosoguanidine; Methylnitrosourea; Nitrosourea Compounds | 1975 |
Alkylating intermediates in nitrosamine metabolism.
Topics: Alkylating Agents; Animals; Binding Sites; Dimethylnitrosamine; DNA; Ethylnitrosourea; Guanine; Kidney; Liver; Nitrosamines; Rats; Time Factors | 1975 |
Identification of the cross-link between human O6-methylguanine-DNA methyltransferase and chloroethylnitrosourea-treated DNA.
Topics: Antineoplastic Agents; Base Sequence; Chromatography, High Pressure Liquid; DNA; Electrophoresis, Polyacrylamide Gel; Ethylnitrosourea; Guanine; Humans; Kinetics; Methyltransferases; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase | 1992 |
Sequence-selective depurination, DNA interstrand cross-linking and DNA strand break formation associated with alkylated DNA.
Topics: Alkylation; Base Sequence; Cross-Linking Reagents; DNA; DNA Damage; Ellagic Acid; Ethylnitrosourea; Guanine; Methyl Methanesulfonate; Molecular Sequence Data; Spermidine | 1992 |
Efficient repair of O6-ethylguanine, but not O4-ethylthymine or O2-ethylthymine, is dependent upon O6-alkylguanine-DNA alkyltransferase and nucleotide excision repair activities in human cells.
Topics: B-Lymphocytes; Cell Line; DNA Repair; Ethylnitrosourea; Guanine; Humans; Kinetics; Methyltransferases; Models, Biological; O(6)-Methylguanine-DNA Methyltransferase; Pyrimidine Dimers; Substrate Specificity; Thymine; Time Factors | 1992 |
High susceptibility of analbuminemic rats to neurogenic tumor induction by transplacental administration of N-ethyl-N-nitrosourea.
Topics: Animals; Brain Neoplasms; Disease Susceptibility; DNA, Neoplasm; Ethylnitrosourea; Female; Guanine; Injections, Subcutaneous; Male; Placenta; Pregnancy; Rats; Rats, Inbred Strains; Spinal Cord Neoplasms | 1992 |
Modulation of ethylnitrosourea-induced toxicity and mutagenicity in human cells by O6-benzylguanine.
Topics: Alkylation; Cell Line, Transformed; Cell Survival; DNA Repair; Ethylnitrosourea; Guanine; Humans; Lymphocytes; Methyltransferases; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Phenotype | 1992 |
N-(2-chloroethyl)-N-nitrosoureas covalently bound to nonionic and monocationic lexitropsin dipeptides. Synthesis, DNA affinity binding characteristics, and reactions with 32P-end-labeled DNA.
Topics: Alkylation; Base Sequence; Binding Sites; Cations; Distamycins; DNA; DNA Restriction Enzymes; Ethylnitrosourea; Guanidines; Guanine; Molecular Sequence Data; Molecular Structure; Netropsin | 1990 |
Repair of O6-ethylguanine in DNA protects rat 208F cells from tumorigenic conversion by N-ethyl-N-nitrosourea.
Topics: Animals; Carmustine; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Clone Cells; DNA; DNA Repair; Ethylnitrosourea; Guanine; Kinetics; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Rats | 1990 |
Immunocytochemical analysis of O6-alkylguanine shows tissue specific formation in and removal from esophageal and liver DNA in rats treated with methylbenzylnitrosamine, dimethylnitrosamine, diethylnitrosamine and ethylnitrosourea.
Topics: Animals; Carcinogens; Cell Nucleus; Diethylnitrosamine; Dimethylnitrosamine; DNA Damage; DNA Repair; Esophagus; Ethylnitrosourea; Female; Guanine; Immunoenzyme Techniques; Liver; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Inbred Strains; Substrate Specificity | 1989 |
N-ethyl-N-nitrosourea induces A:T to C:G transversion mutations as well as transition mutations in SOS-induced Escherichia coli.
Topics: Adenine; Base Composition; Base Sequence; Chromosome Deletion; Cytosine; DNA Damage; DNA Repair; DNA, Bacterial; Escherichia coli; Ethylnitrosourea; Genes, Bacterial; Guanine; Molecular Sequence Data; Mutation; SOS Response, Genetics; Thymine | 1989 |
Effect of O6-methylguanine on DNA interstrand cross-link formation by chloroethylnitrosoureas and 2-chloroethyl(methylsulfonyl)methanesulfonate.
Topics: Cell Division; Cell Survival; Cross-Linking Reagents; DNA Damage; DNA Repair; Ethylnitrosourea; Guanine; Humans; Lomustine; Mesylates; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Tumor Cells, Cultured | 1988 |
Ability of various alkylating agents to induce adaptive and SOS responses: a study with lacZ fusion.
Topics: Alkylating Agents; Bacterial Proteins; beta-Galactosidase; DNA Glycosylases; DNA Ligases; DNA Repair; Dose-Response Relationship, Drug; Enzyme Induction; Escherichia coli; Ethylnitrosourea; Genes, Bacterial; Genes, Synthetic; Guanine; Lac Operon; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; N-Glycosyl Hydrolases; Polynucleotide Ligases | 1985 |
DNA sequence selectivity of guanine-N7 alkylation by three antitumor chloroethylating agents.
Topics: Alkylating Agents; Alkylation; Antineoplastic Agents; Autoradiography; Base Sequence; DNA; Ethylnitrosourea; Guanine; Hydrogen-Ion Concentration; Lomustine; Mesylates; Nitrogen Mustard Compounds | 1986 |
DNA-mediated transfer and expression of a human DNA repair gene that demethylates O6-methylguanine.
Topics: Animals; Cell Line; Cricetinae; Cricetulus; DNA Repair; DNA Restriction Enzymes; Drug Resistance; Ethylnitrosourea; Female; Genes; Guanine; Humans; Liver; Methyltransferases; Mycophenolic Acid; O(6)-Methylguanine-DNA Methyltransferase; Ovary; Transformation, Genetic | 1985 |
Alternative pathways for the in vivo repair of O6-alkylguanine and O4-alkylthymine in Escherichia coli: the adaptive response and nucleotide excision repair.
Topics: Alkylation; DNA Repair; DNA, Bacterial; Escherichia coli; Ethylnitrosourea; Guanine; Kinetics; Methylnitrosourea; Mutation; Thymine | 1988 |
Influence of neighboring base sequence on the distribution and repair of N-ethyl-N-nitrosourea-induced lesions in Escherichia coli.
Topics: Base Sequence; DNA Repair; Escherichia coli; Ethylnitrosourea; Guanine; Methylnitronitrosoguanidine; Mutation; Thymine | 1988 |
Immunocytochemical studies on the formation and repair of O6-alkylguanine in rat tissues.
Topics: Animals; Diethylnitrosamine; Dimethylnitrosamine; DNA Repair; Ethylnitrosourea; Guanine; Immunohistochemistry; Islets of Langerhans; Kidney Glomerulus; Liver; Male; Muscle, Smooth; Precancerous Conditions; Rats; Spermatogonia; Tissue Distribution | 1987 |
Distribution of O6-ethylguanine in DNA exposed to ethylnitrosourea in vitro as visualized by electron microscopy using a monoclonal antibody.
Topics: Animals; Antibodies, Monoclonal; DNA; DNA Damage; Ethylnitrosourea; Guanine; Microscopy, Electron; Rats; Software | 1988 |
Enzymatic removal of O6-ethylguanine from mitochondrial DNA in rat tissues exposed to N-ethyl-N-nitrosourea in vivo.
Topics: Animals; Brain; Cell Nucleus; DNA Repair; DNA, Mitochondrial; Ethylnitrosourea; Guanine; Kidney; Kinetics; Male; Mitochondria; Mitochondria, Liver; Rats; Rats, Inbred Strains; Thymidine | 1988 |
Enzymatic elimination of O6-ethylguanine from the DNA of ethylnitrosourea-exposed normal and malignant rat brain cells grown under cell culture versus in vivo conditions.
Topics: Animals; Brain Neoplasms; DNA; DNA Repair; Ethylnitrosourea; Guanine; Kinetics; Rats; Tumor Cells, Cultured | 1988 |
Synthesis and characterization of O6-(2-chloroethyl)guanine: a putative intermediate in the cytotoxic reaction of chloroethylnitrosoureas with DNA.
Topics: Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; DNA; DNA Damage; Ethylnitrosourea; Guanine; Hydrogen-Ion Concentration; Spectrophotometry, Ultraviolet; Time Factors | 1987 |
The binding of 1-(2-hydroxyethyl)-1-nitrosourea to DNA in vitro and to DNA of thymus and marrow in C57BL mice in vivo.
Topics: Alkylation; Animals; Bone Marrow; DNA; DNA Damage; Ethylnitrosourea; Guanine; Mice; Thymus Gland | 1986 |
Quantitative comparison of genetic effects of ethylating agents on the basis of DNA adduct formation. Use of O6-ethylguanine as molecular dosimeter for extrapolation from cells in culture to the mouse.
Topics: Alkylating Agents; Animals; Cell Line; Cells, Cultured; Cricetinae; Cricetulus; DNA; Environmental Exposure; Escherichia coli; Ethyl Methanesulfonate; Ethylnitrosourea; Guanine; Lung; Methylnitronitrosoguanidine; Mice; Mutation; Structure-Activity Relationship; Sulfuric Acid Esters | 1985 |
Inactivation of O6-methylguanine-DNA methyltransferase and sensitization of human tumor cells to killing by chloroethylnitrosourea by O6-methylguanine as a free base.
Topics: Cell Survival; DNA Repair; Ethylnitrosourea; Fibroblasts; Guanine; Humans; Methyltransferases; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Substrate Specificity | 1986 |
Enzymatic elimination of O6-ethylguanine and stability of O4-ethylthymine in the DNA of malignant neural cell lines exposed to N-ethyl-N-nitrosourea in culture.
Topics: Animals; Cells, Cultured; Clone Cells; DNA Repair; Ethylnitrosourea; Guanine; Kinetics; Neurons; Rats; Thymine | 1986 |
Differential formation of O6-ethylguanine in the DNA of rat brain chromatin fibers of different folding levels exposed to N-ethyl-N-nitrosourea in vitro.
Topics: Alkylation; Animals; Brain; Chromatin; DNA; Ethylnitrosourea; Guanine; In Vitro Techniques; Nitrosourea Compounds; Nucleosomes; Rats | 1985 |
Repair of O6-(2-chloroethyl)guanine mediates the biological effects of chloroethylnitrosoureas.
Topics: Alkylation; Animals; Carmustine; Cell Line; Cell Survival; DNA; DNA Repair; Drug Resistance; Ethylnitrosourea; Guanine; Kinetics; L Cells; Methyltransferases; Mice; O(6)-Methylguanine-DNA Methyltransferase; Sister Chromatid Exchange | 1985 |
Mutagenesis and O6-ethylguanine levels in DNA from N-nitroso-N-ethylurea-treated Salmonella typhimurium: evidence for a high mutational efficiency of O6-ethylguanine.
Topics: DNA, Bacterial; Ethylnitrosourea; Guanine; Mutagenicity Tests; Mutagens; Mutation; Nitrosourea Compounds; Salmonella typhimurium | 1984 |
Suppression of cross-link formation in chloroethylnitrosourea-treated DNA by an activity in extracts of human leukemic lymphoblasts.
Topics: Antineoplastic Agents; Cell Line; DNA, Neoplasm; Ethylnitrosourea; Guanine; Humans; Kinetics; Leukemia, Lymphoid; Methylnitrosourea; Methyltransferases; Nitrosourea Compounds; O(6)-Methylguanine-DNA Methyltransferase | 1984 |
Repair of O6-ethylguanine DNA lesions in isolated cell nuclei. Presence of the activity in the chromatin proteins.
Topics: Animals; Cell Nucleus; Chemical Phenomena; Chemistry; Chromatin; Chromatography, Paper; Diethylnitrosamine; DNA Repair; Ethylnitrosourea; Guanine; Liver; Male; Rats; Rats, Inbred Strains | 1983 |
Alkylation of the O6 of guanine is only one of many chemical events that may initiate carcinogenesis.
Topics: Alkylating Agents; Animals; Carcinogens; Cell Transformation, Neoplastic; DNA; Ethylnitrosourea; Guanine; Methylnitrosourea; Neoplasms, Experimental | 1984 |
Elimination of O6-ethylguanine from the DNA of brain, liver, and other rat tissues exposed to ethylnitrosourea at different stages of prenatal development.
Topics: Animals; Brain; DNA; Ethylnitrosourea; Female; Fetus; Guanine; Kinetics; Liver; Male; Nitrosourea Compounds; Pregnancy; Rats | 1983 |
Retention of promutagenic O6-ethylguanine in the DNA of various rat tissues following transplacental inoculation with ethylnitrosourea.
Topics: Alkylation; Animals; Brain; DNA; DNA Replication; Ethylnitrosourea; Female; Guanine; Kidney; Liver; Maternal-Fetal Exchange; Neoplasms, Experimental; Nitrosourea Compounds; Pregnancy; Rats | 1980 |
Inability of Chinese hamster ovary cells to excise O6-alkylguanine.
Topics: Adenine; Alkylating Agents; Animals; Cricetinae; Cricetulus; DNA; DNA Repair; Ethylnitrosourea; Female; Guanine; Methylnitrosourea; Ovary; Pyrimidine Dimers; Time Factors | 1980 |
Modulation of nitrosourea toxicity in rodent embryonic cells by O6-benzylguanine, a depletor of O6-methylguanine-DNA methyltransferase.
Topics: Animals; Cell Differentiation; Cells, Cultured; DNA Adducts; Ethylnitrosourea; Female; Guanine; Mesencephalon; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Pregnancy; Rats; Rats, Sprague-Dawley | 1995 |
Streptozotocin-induced toxicity in CHO-9 and V79 cells.
Topics: Animals; Cell Cycle; Cell Line; Cell Survival; CHO Cells; Cricetinae; Cricetulus; DNA; DNA Replication; Ethylnitrosourea; Guanine; Methylnitrosourea; Mutagens; Streptozocin; Thymidine | 1995 |
Marked differences in the role of O6-alkylguanine in hprt mutagenesis in T-lymphocytes of rats exposed in vivo to ethylmethanesulfonate, N-(2-hydroxyethyl)-N-nitrosourea, or N-ethyl-N-nitrosourea.
Topics: Adenine; Animals; Base Composition; Base Sequence; Carcinogens; DNA Adducts; DNA, Complementary; Drug Resistance; Ethyl Methanesulfonate; Ethylnitrosourea; Guanine; Hypoxanthine Phosphoribosyltransferase; In Vitro Techniques; Male; Molecular Sequence Data; Mutagenesis; Point Mutation; Polymerase Chain Reaction; Rats; Rats, Inbred Lew; T-Lymphocytes; Thioguanine; Thymidine | 1995 |
A new interference footprinting method for analysing simultaneously protein contacts to phosphate and guanine residues on DNA.
Topics: Base Sequence; DNA; DNA-Binding Proteins; Ethylnitrosourea; Genetic Techniques; Guanine; Molecular Sequence Data; NF-kappa B; Phosphates; Piperidines; Sequence Analysis, DNA; Sodium Hydroxide | 1995 |
Toxoplasma gondii: characterization of a mutant resistant to 6-thioxanthine.
Topics: Animals; Cells, Cultured; Ethylnitrosourea; Fibroblasts; Guanine; Humans; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Mutagenesis; Toxoplasma; Xanthine; Xanthines | 1994 |
Capacity of individual chronic lymphatic leukemia lymphocytes and leukemic blast cells for repair of O6-ethylguanine in DNA: relation to chemosensitivity in vitro and treatment outcome.
Topics: Acute Disease; Carmustine; Cyclophosphamide; Cytarabine; DNA Repair; Doxorubicin; Drug Resistance; Ethylnitrosourea; Glutathione; Guanine; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid; Lymphocytes; Treatment Outcome | 1994 |
Combined depletion of O6-alkylguanine-DNA alkyltransferase and glutathione to modulate nitrosourea resistance in breast cancer.
Topics: Breast Neoplasms; Carmustine; Cell Line; Cell Survival; Drug Resistance; Ethylnitrosourea; Glutathione; Glutathione Transferase; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase | 1994 |
Mutagenesis of H-ras codons 11 and 12 in human fibroblasts by N-ethyl-N-nitrosourea.
Topics: Base Sequence; Codon; Ethylnitrosourea; Fibroblasts; Genes, ras; Guanine; Humans; Molecular Sequence Data; Point Mutation; Polymorphism, Restriction Fragment Length | 1993 |
Effects of inhibition of O6-alkylguanine-DNA alkyltransferase in rats on carcinogenesis by methylnitrosourea and ethylnitrosourea.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Ethylnitrosourea; Female; Guanine; Liver; Methylnitrosourea; Methyltransferases; Neoplasms, Experimental; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Inbred F344 | 1994 |
Differential formation and repair of the mutagenic DNA alkylation product O6-ethylguanine in transcribed and nontranscribed genes of the rat.
Topics: Alkylation; Animals; Carcinoma, Hepatocellular; Cell Line; DNA Repair; DNA, Neoplasm; Ethylnitrosourea; Gene Expression; Guanine; Liver Neoplasms; Mutagenesis; Rats; Transcription, Genetic; Tumor Cells, Cultured | 1994 |
Quantitative relationship between ethylated DNA bases and gene mutation at two loci in CHO cells.
Topics: Adenine; Alkylating Agents; Alkylation; Animals; CHO Cells; Chromatography, High Pressure Liquid; Cricetinae; DNA; Dose-Response Relationship, Drug; Ethyl Methanesulfonate; Ethylnitrosourea; Guanine; Hypoxanthine Phosphoribosyltransferase; Mutagenicity Tests; Mutation; Sodium-Potassium-Exchanging ATPase; Sulfuric Acid Esters | 1993 |
Synthesis of the prototype DNA-protein cross-link, 1-(guan-1-yl)-2-(cysteine-S-yl)ethane, and its role in the reactions of the haloethylnitrosoureas.
Topics: Cross-Linking Reagents; Cysteine; DNA; DNA Damage; Drug Interactions; Ethylnitrosourea; Guanine; Spectrophotometry, Ultraviolet | 1993 |
Enhancement effect of O6-fluorobenzylguanines on chloroethylnitrosourea cytotoxicity in tumor cells.
Topics: Antineoplastic Agents; Cell Division; Drug Synergism; Ethylnitrosourea; Guanine; HeLa Cells; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Tumor Cells, Cultured | 1996 |
Comparison of inhibition of glucose-stimulated insulin secretion in rat islets of Langerhans by streptozotocin and methyl and ethyl nitrosoureas and methanesulphonates. Lack of correlation with nitric oxide-releasing or O6-alkylating ability.
Topics: Alkylating Agents; Animals; Cyclic GMP; Ethyl Methanesulfonate; Ethylnitrosourea; Glucose; Guanine; Insulin; Islets of Langerhans; Methyl Methanesulfonate; Methylnitrosourea; Nitric Oxide; Rats; Rats, Sprague-Dawley; Streptozocin; Structure-Activity Relationship | 1995 |
Formation and persistence of O6-ethylguanine in genomic and transgene DNA in liver and brain of lambda(lacZ) transgenic mice treated with N-ethyl-N-nitrosourea.
Topics: Animals; Bacteriophage lambda; Brain; DNA; DNA Repair; Ethylnitrosourea; Female; Genome; Guanine; Immunoblotting; Lac Operon; Liver; Mice; Mice, Transgenic; Mutagenicity Tests; Mutagens; Polymerase Chain Reaction; Sensitivity and Specificity | 1996 |
Detection of N7-(2-hydroxyethyl)guanine adducts in DNA and 9L cells treated with 1-(2-chloroethyl)-1-nitrosourea.
Topics: Animals; Antineoplastic Agents; Cattle; Chromatography, High Pressure Liquid; DNA; DNA Adducts; Electrochemistry; Ethylnitrosourea; Guanine; L Cells; Mice; Sensitivity and Specificity; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet | 1997 |
Contacts between Bacillus subtilis catabolite regulatory protein CcpA and amyO target site.
Topics: alpha-Amylases; Bacillus subtilis; Bacterial Proteins; Base Sequence; Binding Sites; DNA Methylation; DNA-Binding Proteins; DNA, Bacterial; Ethylnitrosourea; Genes, Bacterial; Guanine; Nucleic Acid Conformation; Peptide Fragments; Phosphates; Repressor Proteins; Sulfuric Acid Esters; Trypsin | 1997 |
Effect of nucleotide excision repair on hprt gene mutations in rodent cells exposed to DNA ethylating agents.
Topics: Alkylating Agents; Animals; CHO Cells; Cricetinae; DNA; DNA Damage; DNA Mutational Analysis; DNA Repair; Ethyl Methanesulfonate; Ethylnitrosourea; Genes; Guanine; Hypoxanthine Phosphoribosyltransferase; Mutagenicity Tests; Mutagens; Mutation; Species Specificity; Thymine | 1997 |
DNA adducts, mutant frequencies, and mutation spectra in various organs of lambda lacZ mice exposed to ethylating agents.
Topics: Animals; Bone Marrow; Brain; Diethylnitrosamine; DNA Adducts; Ethyl Methanesulfonate; Ethylnitrosourea; Female; Guanine; Lac Operon; Liver; Mice; Mice, Transgenic; Mutagens | 1998 |
Fast repair of O6-ethylguanine, but not O6-methylguanine, in transcribed genes prevents mutation of H-ras in rat mammary tumorigenesis induced by ethylnitrosourea in place of methylnitrosourea.
Topics: Alkylation; Animals; Animals, Genetically Modified; DNA Adducts; DNA Repair; DNA, Neoplasm; Ethylnitrosourea; Female; Genes, ras; Guanine; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; O(6)-Methylguanine-DNA Methyltransferase; Point Mutation; Rats; Transcription, Genetic | 1998 |
Formation and persistence of the miscoding DNA alkylation product O6-ethylguanine in male germ cells of the hamster.
Topics: Animals; Antibodies, Monoclonal; Carcinogens; Cricetinae; Diethylnitrosamine; DNA; DNA Adducts; DNA Damage; DNA Repair; Ethylnitrosourea; Fluorescent Antibody Technique, Indirect; Guanine; Male; Mesocricetus; Spermatogonia | 1997 |
Effects of O6-benzylguanine on growth and differentiation of P19 embryonic carcinoma cells treated with alkylating agents.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Carcinogens; Carcinoma, Embryonal; Cell Differentiation; Cell Division; Cell Survival; DNA Repair; Ethyl Methanesulfonate; Ethylnitrosourea; Guanine; Mesencephalon; Methyl Methanesulfonate; Methylnitrosourea; Mice; Neurons; O(6)-Methylguanine-DNA Methyltransferase; Rats; Tretinoin; Tumor Cells, Cultured | 1998 |
Alkylpurine-DNA-N-glycosylase knockout mice show increased susceptibility to induction of mutations by methyl methanesulfonate.
Topics: Animals; Bone Marrow Cells; Cells, Cultured; Dacarbazine; DNA Glycosylases; Erythrocytes; Ethylnitrosourea; Female; Fibroblasts; Guanine; Hypoxanthine Phosphoribosyltransferase; Leukocyte Count; Liver; Male; Methyl Methanesulfonate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Mutagens; Mutation; N-Glycosyl Hydrolases; Temozolomide | 1998 |
DNA repair and cellular resistance to alkylating agents in chronic lymphocytic leukemia.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cell Nucleus; Chlorambucil; Cyclophosphamide; DNA Damage; DNA Repair; DNA, Neoplasm; Drug Resistance, Neoplasm; Ethylnitrosourea; Guanine; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Prednisone; Vincristine | 1997 |
Retroviral transfer of a bacterial alkyltransferase gene into murine bone marrow protects against chloroethylnitrosourea cytotoxicity.
Topics: Animals; Antineoplastic Agents, Alkylating; Bacterial Proteins; Bone Marrow; Carmustine; Enzyme Inhibitors; Escherichia coli Proteins; Ethylnitrosourea; Feasibility Studies; Gene Transfer Techniques; Guanine; Mice; Mice, Inbred CBA; O(6)-Methylguanine-DNA Methyltransferase; Retroviridae; Transcription Factors | 1995 |
Influence of O6-benzylguanine on the anti-tumour activity and normal tissue toxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea and molecular combinations of 5-fluorouracil and 2-chloroethyl-1-nitrosourea in mice.
Topics: Animals; Antineoplastic Agents, Alkylating; Carmustine; Colony-Forming Units Assay; Drug Combinations; Drug Resistance, Neoplasm; Enzyme Inhibitors; Ethylnitrosourea; Fluorouracil; Guanine; Humans; Male; Mice; Mice, Nude; O(6)-Methylguanine-DNA Methyltransferase; Tumor Stem Cell Assay | 1999 |
The effect of folate deficiency on the hprt mutational spectrum in Chinese hamster ovary cells treated with monofunctional alkylating agents.
Topics: Alkylating Agents; Animals; Base Pairing; CHO Cells; Cricetinae; DNA Mutational Analysis; DNA Primers; DNA Repair; Ethyl Methanesulfonate; Ethylnitrosourea; Folic Acid Deficiency; Guanine; Hypoxanthine Phosphoribosyltransferase; Mutagens; Mutation; Polymerase Chain Reaction; Thioguanine | 1999 |
Acquired resistance to O6-benzylguanine plus chloroethylnitrosoureas in human breast cancer.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carmustine; Drug Resistance, Neoplasm; Drug Synergism; Ethylnitrosourea; Glutathione; Guanine; Humans; O(6)-Methylguanine-DNA Methyltransferase; Tumor Cells, Cultured | 1999 |
Retroviral-mediated expression of the P140A, but not P140A/G156A, mutant form of O6-methylguanine DNA methyltransferase protects hematopoietic cells against O6-benzylguanine sensitization to chloroethylnitrosourea treatment.
Topics: Animals; Antineoplastic Agents; Carcinoma; Ethylnitrosourea; Female; Genetic Vectors; Guanine; Hematopoietic Stem Cells; Humans; Leukemia L1210; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Retroviridae; Tumor Cells, Cultured | 1999 |
Measurement of HPRT mutations in splenic lymphocytes and haemoglobin adducts in erythrocytes of Lewis rats exposed to ethylene oxide.
Topics: Administration, Inhalation; Administration, Oral; Animals; Carcinogens; Chromosome Aberrations; DNA Adducts; Erythrocytes; Ethylene Oxide; Ethylnitrosourea; Guanine; Hemoglobins; Hypoxanthine Phosphoribosyltransferase; Injections, Intraperitoneal; Lymphocytes; Male; Micronucleus Tests; Mutation; Rats; Rats, Inbred Lew; Sister Chromatid Exchange; Spleen | 1999 |
DNA repair: counteragent in mutagenesis and carcinogenesis-- accomplice in cancer therapy resistance.
Topics: Adenocarcinoma; Alkylating Agents; Animals; Carcinogens; DNA; DNA Adducts; DNA Repair; Drug Resistance, Neoplasm; Ethylnitrosourea; Female; Genes, ras; Guanine; Humans; Mammary Neoplasms, Experimental; Methylnitrosourea; Mutagens; Mutation; Rats | 2000 |
Repair of ethylnitrosourea-induced DNA damage in the newborn rat. I. Alkali-labile lesions and in situ breaks.
Topics: Adenine; Alkylating Agents; Animals; Animals, Newborn; Brain; DNA; DNA Damage; DNA Repair; Ethylnitrosourea; Female; Guanine; Hydrogen-Ion Concentration; Kidney; Liver; Lung; Male; Rats; Rats, Sprague-Dawley; Sodium Hydroxide | 1980 |
Induction of lacI mutations in Big Blue Rat-2 cells treated with 1-(2-hydroxyethyl)-1-nitrosourea: a model system for the analysis of mutagenic potential of the hydroxyethyl adducts produced by 1,3-bis (2-chloroethyl)-1-nitrosourea.
Topics: Animals; Bacterial Proteins; Base Sequence; Carmustine; Cell Line; Deoxyguanosine; DNA Adducts; DNA Mutational Analysis; Escherichia coli Proteins; Ethylnitrosourea; Guanine; Lac Repressors; Mutagenicity Tests; Mutagens; Mutation; Rats; Repressor Proteins | 2001 |
Characterization of a new allele of Ames waltzer generated by ENU mutagenesis.
Topics: Acoustic Stimulation; Adenine; Alleles; Animals; Auditory Threshold; Base Sequence; Cadherin Related Proteins; Cadherins; Deafness; DNA Mutational Analysis; Ethylnitrosourea; Evoked Potentials, Auditory, Brain Stem; Female; Guanine; Hair Cells, Auditory, Inner; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Microscopy, Electron, Scanning; Mutagens; Mutation; Organ of Corti; Phenotype; Protein Precursors; Vestibular Diseases | 2005 |
hOGG1 recognizes oxidative damage using the comet assay with greater specificity than FPG or ENDOIII.
Topics: Animals; Bromates; Comet Assay; Deoxyribonuclease (Pyrimidine Dimer); Dimethyl Sulfoxide; DNA Damage; DNA Glycosylases; DNA Repair Enzymes; DNA-Formamidopyrimidine Glycosylase; Escherichia coli Proteins; Ethylnitrosourea; Gamma Rays; Guanine; Humans; Leukemia L5178; Methyl Methanesulfonate; Mice; Oxidation-Reduction; Sensitivity and Specificity | 2006 |
Polymorphisms of phase II xenobiotic-metabolizing and DNA repair genes and in vitro N-ethyl-N-nitrosourea-induced O6-ethylguanine levels in human lymphocytes.
Topics: Aged; DNA Repair Enzymes; Ethylnitrosourea; Female; Guanine; Humans; Lymphocytes; Male; Metabolic Detoxication, Phase II; Middle Aged; Polymorphism, Genetic; Xenobiotics | 2007 |
Niacin deficiency delays DNA excision repair and increases spontaneous and nitrosourea-induced chromosomal instability in rat bone marrow.
Topics: Animals; Bone Marrow; Chromosomal Instability; Chromosome Aberrations; Comet Assay; DNA Adducts; DNA Repair; Ethylnitrosourea; Guanine; Male; Micronucleus Tests; Niacin; Rats; Rats, Long-Evans | 2007 |
The removal of alkylation products from the DNA of Escherichia coli cells treated with the carcinogens N-ethyl-N-nitrosourea and N-methyl-N-nitrosourea: influence of growth conditions and DNA repair defects.
Topics: Adenine; Alkylating Agents; Alkylation; Carcinogens; DNA Repair; DNA, Bacterial; Escherichia coli; Ethylnitrosourea; Guanine; Methylation; Methylnitrosourea | 1980 |
Investigations on the effect of O(6)-benzylguanine on the formation of dG-dC interstrand cross-links induced by chloroethylnitrosoureas in human glioma cells using stable isotope dilution high-performance liquid chromatography electrospray ionization tand
Topics: Alkylating Agents; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Deoxycytidine; Deoxyguanosine; DNA; DNA Damage; Ethylnitrosourea; Glioma; Guanine; Humans; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2014 |