ethylmorphine and 1-4-diazepane

ethylmorphine has been researched along with 1-4-diazepane* in 1 studies

Other Studies

1 other study(ies) available for ethylmorphine and 1-4-diazepane

Article	Year
Discovery of novel series of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones as human chymase inhibitors using structure-based drug design. Bioorganic & medicinal chemistry, 2013, Jul-15, Volume: 21, Issue:14 A novel series of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones were explored as human chymase inhibitors using structure-based drug design according to the X-ray cocrystal structure of chymase and compound 1. The optimization focused on the prime site led to the attainment of compounds that showed potent inhibitory activity, and among them, 18R shows a novel interaction mode. Topics: Azepines; Catalytic Domain; Chymases; Crystallography, X-Ray; Drug Design; Enzyme Activation; Enzyme Inhibitors; Ethylmorphine; Humans; Inhibitory Concentration 50; Molecular Structure; Structure-Activity Relationship	2013

Article

Year

Discovery of novel series of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones as human chymase inhibitors using structure-based drug design.

Bioorganic & medicinal chemistry, 2013, Jul-15, Volume: 21, Issue:14

A novel series of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones were explored as human chymase inhibitors using structure-based drug design according to the X-ray cocrystal structure of chymase and compound 1. The optimization focused on the prime site led to the attainment of compounds that showed potent inhibitory activity, and among them, 18R shows a novel interaction mode.

Topics: Azepines; Catalytic Domain; Chymases; Crystallography, X-Ray; Drug Design; Enzyme Activation; Enzyme Inhibitors; Ethylmorphine; Humans; Inhibitory Concentration 50; Molecular Structure; Structure-Activity Relationship

2013