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ethylketocyclazocine and u-50488

ethylketocyclazocine has been researched along with u-50488 in 92 studies

Research

Studies (92)

Timeframe	Studies, this research(%)	All Research%
pre-1990	62 (67.39)	18.7374
1990's	27 (29.35)	18.2507
2000's	2 (2.17)	29.6817
2010's	1 (1.09)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Akil, H; Goldstein, A; Mansour, A; Meng, F; Thompson, RC; Watson, SJ; Xie, GX	1
Bell, GI; Breder, CD; Kong, H; Raynor, K; Reisine, T; Takeda, J; Yasuda, K	1
Chen, C; Li, JG; Liu-Chen, LY; Luo, LY; Zhu, J	1
Craft, RM; Dykstra, LA	3
Bhargava, HN; Gulati, A; Ramarao, P	2
Bhargava, HN; Gulati, A; Rahmani, NH	1
al-Shireida, MF; el-Sharkawy, TY; Pilcher, CW	1
Cook, L; Holtzman, SG; Steinfels, GF	1
Cone, EJ; Vaupel, DB	1
Negus, SS; Picker, MJ; Powell, KR	1
Abbott, FV	1
Shea-Donohue, T; Touzeau, PL	1
Hoss, W; Periyasamy, S	1
Doty, P; Dykstra, LA; Mattox, SR; Negus, SS; Picker, MJ	1
Fedynyshyn, JP; Kwiat, G; Lee, NM	1
Dougall, IG; Leff, P	1
Craft, RM; Dykstra, LA; Picker, MJ	1
Ho, BY; Takemori, AE	1
Bueno, L; Gué, M; Junien, JL	1
DiBona, GF; Jones, SY; Kapusta, DR	1
Bykov, V; De Costa, BR; France, CP; Jacobson, AE; Rice, KC; Rothman, RB; Woods, JH	1
Clark, JA; Edelson, M; Hersh, B; Liu, L; Pasternak, GW; Price, M	1
Cornfeldt, M; Fielding, S; Gorney, B; Locke, KW	1
Bhargava, HN; Ramarao, P	1
Doty, P; Dykstra, LA; Picker, MJ	1
Blake, JW; DeQuick, D; Kamerling, S; Tai, C; Tobin, T; Weckman, TJ; Wood, T	1
Dykstra, LA; Picker, MJ	1
Nunan, L; Porreca, F; Sheldon, RJ	1
Dykstra, LA; Massie, CA; Picker, M	1
Burks, TF; Fox, DA	1
Clark, JA; Pasternak, GW	1
Ho, BY; Naeseth, JS; Portoghese, PS; Takemori, AE	1
Dykstra, LA; Massie, CA	1
Su, TP	1
Cooper, SJ; Jackson, A; Kirkham, TC	1
Illes, P; Ramme, D	1
Burks, TF; Deupree, D; Hruby, V; Hsiao, S; Mosberg, HI; Porreca, F; Spencer, RL	1
Lipkowski, AW; Portoghese, PS; Takemori, AE	1
Russell, NJ; Schaible, HG; Schmidt, RF	1
Schmauss, C	1
Dickenson, AH; Knox, RJ	1
Bhargava, HN; Das, S	1
Benyhe, S; Borsodi, A; Hepp, J; Khan, A; Medzihradszky, K; Simon, J; Szücs, M; Wollemann, M	1
Belisle, S; Bellabarba, D; Gallo-Payet, N; Lehoux, JG; Lemaire, S; Petit, A	1
Buéno, L; Gué, M; Hondé, C; Junien, JL; Pascaud, X	1
Cooper, SJ; Jackson, A	2
Alvinerie, M; Bueno, L; Gue, M; Honde, C; Junien, JL; Pascaud, X	1
Portoghese, PS; Takemori, AE	1
Burks, TF; Hirning, LD; Porreca, F	1
Hayes, A; Kelly, A	1
Barber, DJ; Cooper, SJ; Jackson, A; Moores, WR	1
Hirst, M; Kavaliers, M; Rangeley, RW; Teskey, GC	1
Hayes, AG; Skingle, M; Tyers, MB	1
Hirst, M; Kavaliers, M	1
Hynes, MD; Leander, JD; Reel, JK; Zimmerman, DM	1
Hart, JC; Leander, JD; Zerbe, RL	1
Donahoe, J; Kamerling, S; Tobin, T; Weckman, T	1
Dykstra, LA; Gmerek, DE; Winger, G; Woods, JH	1
Dykstra, LA; Gmerek, DE; Woods, JH	1
Gormezano, I; Harvey, JA; Schindler, CW	1
Dykstra, LA; Picker, M	1
Ishihara, K; Iwama, T; Satoh, M; Takagi, H	1
Blackburn, TP; Borkowski, KR; Friend, J; Rance, MJ	1
Belknap, JK; Danielson, PW; Laursen, SE; Noordewier, B	1
Dykstra, LA; Heise, JW; Picker, M	1
Collins, RJ; Tang, AH	1
Fitzjarrell, AT; Heath, RG; Walker, CF	1
Bardon, T; Pairet, M; Ruckebusch, Y	1
Leander, JD	2
Corbett, AD; Gillan, MG; Kosterlitz, HW; McKnight, AT; Paterson, SJ; Robson, LE	1
Pairet, M; Ruckebusch, Y	1
Neil, A	1
Altura, BM; Altura, BT; Quirion, R	1
Bélisle, S; Bellabarba, D; Gallo-Payet, N; Lehoux, JG; Petit, A	1
Bhargava, HN; Matwyshyn, GA; Reddy, PL	1
Barg, J; Nah, SY; Saya, D; Vogel, Z	1
Walker, EA; Young, AM	1
Hamann, SR; Martin, WR; Parvini, S	1
Bhargava, HN; Gudehithlu, KP; Matwyshyn, GA	1
Lin, CE; Mello, NK; Negus, SS; Portoghese, PS	1
Makhay, MM; Poling, A; Young, AM	1
Fábián, G; Offermanns, S; Rottmann, M; Spicher, K; Szücs, M	1
Holtzman, SG; Powell, KR	1
Mello, NK; Negus, SS	1
Brandt, W; Cambareri, A; Englberger, W; Friderichs, E; Haurand, M; Holzgrabe, U; Kögel, B; Kuhl, U; Siener, T; Strassburger, W	1
Benaderet, TS; Bishop-Mathis, K; Dersch, CM; Partilla, JS; Prisinzano, TE; Rothman, RB; Simpson, DS; Wang, X; Xu, H	1
Li, M; McMillan, DE; Wessinger, WD	1

Reviews

2 review(s) available for ethylketocyclazocine and u-50488

Article	Year
Narcotic analgesics, their detection and pain measurement in the horse: a review. Equine veterinary journal, 1989, Volume: 21, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Butorphanol; Chromatography, Thin Layer; Cyclazocine; Ethylketocyclazocine; Etorphine; Fentanyl; Horses; Morphine; Pain Measurement; Pentazocine; Pyrrolidines; Radioimmunoassay; Receptors, Opioid	1989
Endorphins and food intake: kappa opioid receptor agonists and hyperphagia. Pharmacology, biochemistry, and behavior, 1985, Volume: 23, Issue:5 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzodiazepines; Benzomorphans; Butorphanol; Choice Behavior; Cyclazocine; Diuresis; Drinking; Dynorphins; Eating; Endorphins; Ethylketocyclazocine; Humans; Morphine; Narcotic Antagonists; Phenazocine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Satiety Response	1985

Article

Year

Narcotic analgesics, their detection and pain measurement in the horse: a review.

Equine veterinary journal, 1989, Volume: 21, Issue:1

Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Butorphanol; Chromatography, Thin Layer; Cyclazocine; Ethylketocyclazocine; Etorphine; Fentanyl; Horses; Morphine; Pain Measurement; Pentazocine; Pyrrolidines; Radioimmunoassay; Receptors, Opioid

1989

Endorphins and food intake: kappa opioid receptor agonists and hyperphagia.

Pharmacology, biochemistry, and behavior, 1985, Volume: 23, Issue:5

Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzodiazepines; Benzomorphans; Butorphanol; Choice Behavior; Cyclazocine; Diuresis; Drinking; Dynorphins; Eating; Endorphins; Ethylketocyclazocine; Humans; Morphine; Narcotic Antagonists; Phenazocine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Satiety Response

1985

Other Studies

90 other study(ies) available for ethylketocyclazocine and u-50488

Article	Year
Cloning and pharmacological characterization of a rat kappa opioid receptor. Proceedings of the National Academy of Sciences of the United States of America, 1993, Nov-01, Volume: 90, Issue:21 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Analgesics; Animals; Benzeneacetamides; Cell Line; Cell Membrane; Cloning, Molecular; Corpus Striatum; Cyclic AMP; DNA Primers; DNA, Complementary; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gene Library; In Situ Hybridization; Inositol 1,4,5-Trisphosphate; Kinetics; Ligands; Molecular Sequence Data; Pyrrolidines; Rats; Receptors, Opioid, kappa; Restriction Mapping; RNA, Messenger; Transfection	1993
Cloning and functional comparison of kappa and delta opioid receptors from mouse brain. Proceedings of the National Academy of Sciences of the United States of America, 1993, Jul-15, Volume: 90, Issue:14 Topics: Amino Acid Sequence; Animals; Base Sequence; Brain Chemistry; Cloning, Molecular; In Situ Hybridization; Mice; Molecular Sequence Data; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Somatostatin; RNA, Messenger; Sequence Homology, Amino Acid; Substrate Specificity; Tissue Distribution	1993
Activation of the cloned human kappa opioid receptor by agonists enhances [35S]GTPgammaS binding to membranes: determination of potencies and efficacies of ligands. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 282, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylate Cyclase Toxin; Animals; Binding Sites; Cell Membrane; CHO Cells; Cholera Toxin; Cloning, Molecular; Cricetinae; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Humans; Kinetics; Magnesium; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, kappa; Recombinant Proteins; Sodium; Sulfur Radioisotopes; Virulence Factors, Bordetella	1997
Agonist and antagonist activity of kappa opioids in the squirrel monkey: I. Antinociception and urine output. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Benzodiazepines; Benzomorphans; Drug Interactions; Ethylketocyclazocine; Male; Methadone; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Nociceptors; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri; Urination	1992
Agonist and antagonist activity of kappa opioids in the squirrel monkey: II. Effect of chronic morphine treatment. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzodiazepines; Benzomorphans; Drug Interactions; Drug Tolerance; Ethylketocyclazocine; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Nociceptors; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Saimiri; Shock; Time Factors	1992
Down-regulation of brain and spinal cord K-opiate receptors in spontaneously hypertensive, Wistar-Kyoto normotensive, and Sprague-Dawley rats by chronic treatment with U-50, 488H. Biochemical pharmacology, 1991, Jun-21, Volume: 42, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Blood Pressure; Cerebral Cortex; Down-Regulation; Ethylketocyclazocine; Heart Rate; Male; Pyrrolidines; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY; Receptors, Opioid; Receptors, Opioid, kappa; Spinal Cord	1991
Effects of morphine tolerance-dependence and abstinence on kappa-opiate receptors of rat brain and spinal cord. Biochemical pharmacology, 1991, Aug-22, Volume: 42, Issue:6 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Body Temperature Regulation; Brain; Drug Tolerance; Ethylketocyclazocine; Male; Morphine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Spinal Cord; Substance-Related Disorders; Time Factors	1991
Vascular effects of some opioid receptor agonists. Canadian journal of physiology and pharmacology, 1991, Volume: 69, Issue:6 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Calcium Channel Blockers; Dinoprost; Endothelium, Vascular; Ethylketocyclazocine; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle, Smooth, Vascular; Narcotic Antagonists; Norepinephrine; Potassium; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Vasodilation	1991
Discriminative stimulus effects of spiradoline, a kappa-opioid agonist. Psychopharmacology, 1991, Volume: 105, Issue:4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Butorphanol; Discrimination, Psychological; Ethylketocyclazocine; Generalization, Stimulus; Male; Morphine; Nalorphine; Phencyclidine; Pyrrolidines; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu	1991
Pharmacodynamic and pharmacokinetic actions of ketocyclazocine enantiomers in the dog: absence of sigma- or phencyclidine-like activity. The Journal of pharmacology and experimental therapeutics, 1991, Volume: 256, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Dogs; Dose-Response Relationship, Drug; Drug Administration Schedule; Ethylketocyclazocine; Female; Morphine; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, sigma; Stereoisomerism; Time Factors	1991
Differential cross-tolerance to mu and kappa opioid agonists in morphine-tolerant rats responding under a schedule of food presentation. Psychopharmacology, 1991, Volume: 103, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Chlorpromazine; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Tolerance; Ethylketocyclazocine; Fentanyl; Food; Male; Methadone; Morphine; Naloxone; Narcotics; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reinforcement Schedule	1991
beta-Funaltrexamine antagonizes the analgesic effects of mu and kappa agonists in the formalin test. Pharmacology, biochemistry, and behavior, 1990, Volume: 37, Issue:4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dose-Response Relationship, Drug; Ethylketocyclazocine; Formaldehyde; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Urination	1990
Differential cross-tolerance to opioids in squirrel monkeys responding under a shock titration schedule. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 252, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Cyclazocine; Drug Tolerance; Electroshock; Ethylketocyclazocine; Male; Methadone; Morphine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri	1990
Kappa agonists inhibit gastric emptying but not acid secretion in rhesus monkeys. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 253, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antihypertensive Agents; Cyclazocine; Dynorphins; Ethylketocyclazocine; Gastric Acid; Gastric Emptying; Macaca mulatta; Male; Narcotics; Peptide Fragments; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Sodium	1990
Kappa opioid receptors stimulate phosphoinositide turnover in rat brain. Life sciences, 1990, Volume: 47, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Cyclazocine; Dynorphins; Enkephalins; Ethylketocyclazocine; Male; Phosphatidylinositols; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa	1990
Discriminative stimulus properties of U50,488 and morphine: effects of training dose on stimulus substitution patterns produced by mu and kappa opioid agonists. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 254, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Cyclazocine; Discrimination Learning; Dose-Response Relationship, Drug; Ethylketocyclazocine; Fentanyl; Male; Methadone; Morphine; Naloxone; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu	1990
Characterization of high affinity opioid binding sites in rat periaqueductal gray P2 membrane. European journal of pharmacology, 1989, Jan-02, Volume: 159, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Male; Membranes; Periaqueductal Gray; Pyrrolidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid	1989
Estimation of affinities and efficacies for kappa-receptor agonists in guinea-pig ileum. British journal of pharmacology, 1989, Volume: 96, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Binding, Competitive; Cyclazocine; Electric Stimulation; Ethylketocyclazocine; Guinea Pigs; In Vitro Techniques; Male; Models, Biological; Morphinans; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa	1989
Effects of morphine in rats treated chronically with U-50,488 H, a kappa opioid receptor agonist. European journal of pharmacology, 1989, Mar-21, Volume: 162, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Binding, Competitive; Brain Chemistry; Catalepsy; Cyclazocine; Drug Tolerance; Ethylketocyclazocine; Male; Membranes; Morphine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Spinal Cord; Time Factors	1989
Differential cross-tolerance to opioid agonists in morphine-tolerant pigeons responding under a schedule of food presentation. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 249, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Chlorpromazine; Columbidae; Conditioning, Operant; Cyclazocine; Dose-Response Relationship, Drug; Drug Tolerance; Ethylketocyclazocine; Female; Morphine; Pyrrolidines; Receptors, Opioid	1989
Serotonergic involvement in the antinociceptive action of and the development of tolerance to the kappa-opioid receptor agonist, U-50, 488H. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 250, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Cyclazocine; Drug Tolerance; Ethylketocyclazocine; Ketanserin; Male; Mice; Pindolol; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Serotonin; Serotonin Antagonists; Sympatholytics	1989
Central and peripheral opioid modulation of gastric relaxation induced by feeding in dogs. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 250, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Cyclazocine; Dogs; Dose-Response Relationship, Drug; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Morphine; Muscle Relaxation; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stomach; Vagotomy; Vagus Nerve	1989
Role of renal nerves in excretory responses to administration of kappa agonists in conscious spontaneously hypertensive rats. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 251, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cyclazocine; Diuresis; Ethylketocyclazocine; Hemodynamics; Hypertension; Kidney; Male; Pyrrolidines; Rats; Rats, Inbred SHR; Receptors, Opioid; Receptors, Opioid, kappa; Sympathetic Nervous System	1989
Pharmacological activities of optically pure enantiomers of the kappa opioid agonist, U50,488, and its cis diastereomer: evidence for three kappa receptor subtypes. European journal of pharmacology, 1989, Aug-29, Volume: 167, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Benzeneacetamides; Benzodiazepines; Benzomorphans; Binding, Competitive; Brain Chemistry; Cyclazocine; Discrimination, Psychological; Ethylketocyclazocine; Female; Guinea Pigs; Macaca mulatta; Male; Membranes; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Stereoisomerism	1989
Kappa opiate receptor multiplicity: evidence for two U50,488-sensitive kappa 1 subtypes and a novel kappa 3 subtype. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 251, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Binding Sites; Cattle; Cerebellum; Cyclazocine; Edetic Acid; Ethylketocyclazocine; Guinea Pigs; In Vitro Techniques; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu	1989
Mu-opioid component of the ethylketocyclazocine (EKC) discriminative stimulus in the rat. Psychopharmacology, 1989, Volume: 99, Issue:4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cyclazocine; Discrimination, Psychological; Dose-Response Relationship, Drug; Ethylketocyclazocine; Fentanyl; Male; Morphine; Naloxone; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, mu	1989
Antagonism of kappa opioid mediated effects in the rat by cyclo(Leu-Gly). Life sciences, 1989, Volume: 45, Issue:26 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Cerebral Cortex; Cyclazocine; Diuresis; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Male; Neuropeptides; Peptides, Cyclic; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Spinal Cord	1989
Differential cross-tolerance to opioid agonists in morphine-tolerant squirrel monkeys responding under a schedule of food presentation. European journal of pharmacology, 1989, Dec-19, Volume: 174, Issue:2-3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Conditioning, Operant; Cyclazocine; Dose-Response Relationship, Drug; Drug Tolerance; Ethylketocyclazocine; Food; Male; Morphine; Narcotics; Pentobarbital; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, mu; Reinforcement Schedule; Saimiri	1989
Discriminative stimulus effects of mu and kappa opioids in the pigeon: analysis of the effects of full and partial mu and kappa agonists. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 249, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Columbidae; Cyclazocine; Discrimination Learning; Ethylketocyclazocine; Fentanyl; Morphinans; Naloxone; Narcotics; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu	1989
Mu antagonist properties of kappa agonists in a model of rat urinary bladder motility in vivo. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzodiazepines; Cyclazocine; Ethylketocyclazocine; Female; Morphine; Morphine Derivatives; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Urinary Bladder	1987
Evaluation of the effects of opioid agonists and antagonists under a delayed matching-to-sample procedure in pigeons. Psychopharmacology, 1987, Volume: 93, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Columbidae; Cyclazocine; Discrimination Learning; Endorphins; Ethylketocyclazocine; Female; Methadone; Morphine; Naloxone; Phencyclidine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma	1987
Roles of central and peripheral mu, delta and kappa opioid receptors in the mediation of gastric acid secretory effects in the rat. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 244, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Cyclazocine; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Gastric Acid; Male; Morphine; Naltrexone; Pyrrolidines; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	1988
U50,488: a kappa-selective agent with poor affinity for mu1 opiate binding sites. Neuropharmacology, 1988, Volume: 27, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cyclazocine; Ethylketocyclazocine; Guinea Pigs; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu	1988
Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 246, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Male; Mice; Morphine; Naltrexone; Oligopeptides; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa	1988
Antagonism of the analgesic effects of mu and kappa opioid agonists in the squirrel monkey. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 246, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Azocines; Benzomorphans; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Fentanyl; Male; Methadone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri	1988
Further demonstration of kappa opioid binding sites in the brain: evidence for heterogeneity. The Journal of pharmacology and experimental therapeutics, 1985, Volume: 232, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Binding Sites; Brain; Cyclazocine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Guinea Pigs; Levallorphan; Peptide Fragments; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Stereoisomerism	1985
Differential effect of stimulation strength in mouse vas deferens on inhibition of neuroeffector transmission by receptor type selective opioids. Naunyn-Schmiedeberg's archives of pharmacology, 1986, Volume: 332, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Cyclazocine; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; In Vitro Techniques; Male; Mice; Morphine Derivatives; Muscle, Smooth; Neuromuscular Junction; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Synaptic Transmission	1986
Centrally-administered opioid selective agonists inhibit drinking in the rat. Pharmacology, biochemistry, and behavior, 1986, Volume: 25, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Cyclazocine; Drinking Behavior; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Male; Morphine; Naloxone; Peptide Fragments; Pyrrolidines; Rats; Receptors, Opioid	1986
Binaltorphimine and nor-binaltorphimine, potent and selective kappa-opioid receptor antagonists. Life sciences, 1987, Mar-30, Volume: 40, Issue:13 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Chemical Phenomena; Chemistry; Cyclazocine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Male; Mice; Morphine; Naloxone; Naltrexone; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa	1987
Opiates inhibit the discharges of fine afferent units from inflamed knee joint of the cat. Neuroscience letters, 1987, Apr-23, Volume: 76, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Arthritis; Cats; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethylketocyclazocine; Morphine; Naloxone; Nociceptors; Pain; Peripheral Nerves; Pyrrolidines	1987
Spinal kappa-opioid receptor-mediated antinociception is stimulus-specific. European journal of pharmacology, 1987, Jun-04, Volume: 137, Issue:2-3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzodiazepines; Benzomorphans; Cyclazocine; Drug Tolerance; Dynorphins; Ethylketocyclazocine; Injections, Spinal; Male; Morphine; Pyrrolidines; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Receptors, Opioid, kappa; Spinal Cord	1987
Effects of selective and non-selective kappa-opioid receptor agonists on cutaneous C-fibre-evoked responses of rat dorsal horn neurones. Brain research, 1987, Jul-07, Volume: 415, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Action Potentials; Animals; Cyclazocine; Dose-Response Relationship, Drug; Dynorphins; Electric Stimulation; Ethylketocyclazocine; Injections, Spinal; Male; Naloxone; Nerve Fibers; Pain; Peptide Fragments; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Skin; Spinal Cord; Time Factors	1987
Inhibition of [3H][3-MeHis2]thyrotropin releasing hormone recognition sites in the rat brain by tifluadom, a kappa opiate receptor agonist. Neuropharmacology, 1987, Volume: 26, Issue:8 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analysis of Variance; Animals; Benzodiazepines; Brain; Cyclazocine; Dynorphins; Ethylketocyclazocine; Kinetics; Male; Peptide Fragments; Pyrrolidines; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Thyrotropin-Releasing Hormone; Thyrotropin-Releasing Hormone	1987
Purification of a kappa-opioid receptor subtype from frog brain. Neuropeptides, 1987, Volume: 10, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain Chemistry; Chromatography, Gel; Cyclazocine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Membranes; Molecular Weight; Naloxone; Peptide Fragments; Pyrrolidines; Rana esculenta; Receptors, Opioid; Receptors, Opioid, kappa; Solubility	1987
Functional opioid receptor sites in human placentas. The Journal of clinical endocrinology and metabolism, 1988, Volume: 66, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Cyclazocine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethylketocyclazocine; Gonadotropin-Releasing Hormone; Humans; Kinetics; Placenta; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thyrotropin-Releasing Hormone	1988
Peripheral antagonistic action of trimebutine and kappa opioid substances on acoustic stress-induced gastric motor inhibition in dogs. European journal of pharmacology, 1988, Jan-27, Volume: 146, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acoustic Stimulation; Analgesics; Analgesics, Opioid; Animals; Benzoates; Benzomorphans; Cyclazocine; Dogs; Ethylketocyclazocine; Gastrointestinal Motility; Injections, Intravenous; Injections, Intraventricular; Naloxone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Stress, Psychological; Trimebutine	1988
Observational analysis of the effects of kappa opioid agonists an open field behaviour in the rat. Psychopharmacology, 1988, Volume: 94, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Benzodiazepines; Benzomorphans; Cyclazocine; Diuretics; Ethylketocyclazocine; Male; Motor Activity; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Time Factors	1988
CNS blockade of acoustic stress-induced gastric motor inhibition by kappa-opiate agonists in dogs. The American journal of physiology, 1988, Volume: 254, Issue:6 Pt 1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acoustic Stimulation; Adrenocorticotropic Hormone; Analgesics; Animals; Cyclazocine; Dogs; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethylketocyclazocine; Gastrointestinal Motility; Hydrocortisone; Pyrrolidines; Stress, Physiological	1988
TENA, a selective kappa opioid receptor antagonist. Life sciences, 1985, Feb-25, Volume: 36, Issue:8 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Azocines; Benzomorphans; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Ileum; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens	1985
Mu, but not kappa, opioid agonists induce contractions of the canine small intestine ex vivo. European journal of pharmacology, 1985, Feb-12, Volume: 109, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Cyclazocine; Dimethylphenylpiperazinium Iodide; Dogs; Ethylketocyclazocine; Gastrointestinal Motility; In Vitro Techniques; Intestine, Small; Morphine; Nalorphine; Phenazocine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu	1985
Profile of activity of kappa receptor agonists in the rabbit vas deferens. European journal of pharmacology, 1985, Apr-16, Volume: 110, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzodiazepines; Benzomorphans; Butorphanol; Cyclazocine; Ethylketocyclazocine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nalorphine; Naloxone; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens	1985
Effects of tifluadom on food consumption compared with chlordiazepoxide and kappa agonists in the rat. Neuropharmacology, 1985, Volume: 24, Issue:9 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzodiazepinones; Benzomorphans; Chlordiazepoxide; Convulsants; Cyclazocine; Drug Interactions; Eating; Ethylketocyclazocine; Flumazenil; Male; Naloxone; Pyrazoles; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa	1985
Effects of kappa opiate agonists on palatable food consumption in non-deprived rats, with and without food preloads. Brain research bulletin, 1985, Volume: 15, Issue:4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Cyclazocine; Eating; Ethylketocyclazocine; Male; Morphine; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Satiety Response	1985
Mu- and kappa-opiate agonists modulate ingestive behaviors in the slug, Limax maximus. Pharmacology, biochemistry, and behavior, 1986, Volume: 24, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cyclazocine; Ethylketocyclazocine; Feeding Behavior; Mollusca; Morphine; Narcotic Antagonists; Narcotics; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Time Factors	1986
Reversal by beta-funaltrexamine of the antinociceptive effect of opioid agonists in the rat. British journal of pharmacology, 1986, Volume: 88, Issue:4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Buprenorphine; Cyclazocine; Ethylketocyclazocine; Fentanyl; Male; Naltrexone; Pain; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu	1986
Food hoarding and ingestion in the deer mouse, Peromyscus maniculatus: selective responses to mu and kappa opiate agonists. Pharmacology, biochemistry, and behavior, 1986, Volume: 25, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cyclazocine; Endorphins; Ethylketocyclazocine; Feeding Behavior; Food Deprivation; Male; Morphine; Peromyscus; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu	1986
Use of beta-funaltrexamine to determine mu opioid receptor involvement in the analgesic activity of various opioid ligands. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Biological Assay; Buprenorphine; Butorphanol; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Etorphine; Fentanyl; Methadone; Mice; Morphine; Muscle Contraction; Nalbuphine; Nalorphine; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, mu	1987
Kappa agonist-induced diuresis: evidence for stereoselectivity, strain differences, independence of hydration variables and a result of decreased plasma vasopressin levels. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 242, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Butorphanol; Cyclazocine; Diuresis; Drinking; Ethylketocyclazocine; Female; Male; Nalorphine; Pyrrolidines; Rats; Rats, Inbred Strains; Rats, Zucker; Receptors, Opioid; Receptors, Opioid, kappa; Stereoisomerism; Vasopressins; Water Deprivation	1987
Dose related effects of the kappa agonist U-50, 488H on behaviour, nociception and autonomic response in the horse. Equine veterinary journal, 1988, Volume: 20, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Autonomic Nervous System; Body Temperature; Chemical Phenomena; Chemistry; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Female; Fentanyl; Heart Rate; Horses; Locomotion; Male; Nociceptors; Pupil; Pyrrolidines; Respiration	1988
Kappa opioids in rhesus monkeys. II. Analysis of the antagonistic actions of quadazocine and beta-funaltrexamine. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 242, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Azocines; Benzomorphans; Cyclazocine; Diuresis; Endorphins; Ethylketocyclazocine; Female; Hot Temperature; Macaca mulatta; Male; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Reaction Time; Tail	1987
Kappa opioids in rhesus monkeys. III. Dependence associated with chronic administration. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 242, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Cyclazocine; Drug Tolerance; Endorphins; Ethylketocyclazocine; Macaca mulatta; Morphinans; Morphine; Narcotic Antagonists; Pentobarbital; Pyrrolidines; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors	1987
Effects of morphine, ethylketocyclazocine, U-50,488H and naloxone on the acquisition of a classically conditioned response in the rabbit. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Cerebellum; Conditioning, Classical; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Female; Male; Morphine; Naloxone; Pyrrolidines; Rabbits	1987
Comparison of the discriminative stimulus properties of U50,488 and morphine in pigeons. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Columbidae; Cyclazocine; Dextroamphetamine; Discrimination Learning; Dose-Response Relationship, Drug; Ethylketocyclazocine; Female; Fentanyl; Methadone; Morphine; Naloxone; Phenazocine; Phencyclidine; Pyrrolidines; Time Factors	1987
Possible mechanism involved in the inhibitory action of U-50, 488H, an opioid kappa agonist, on guinea pig hippocampal CA3 pyramidal neurons in vitro. Journal of pharmacobio-dynamics, 1987, Volume: 10, Issue:10 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Cyclazocine; Ethylketocyclazocine; Glutamates; Guinea Pigs; Hippocampus; In Vitro Techniques; Male; Neurons; Procaine; Pyramidal Tracts; Pyrrolidines; Tetrodotoxin; Veratrine	1987
On the mechanisms of kappa-opioid-induced diuresis. British journal of pharmacology, 1986, Volume: 89, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenal Medulla; Animals; Benzodiazepines; Catecholamines; Corticosterone; Cyclazocine; Diuresis; Ethylketocyclazocine; Male; Naloxone; Narcotics; Pyrrolidines; Rats; Sympatholytics	1986
Selective breeding for levorphanol-induced antinociception on the hot-plate assay: commonalities in mechanism of action with morphine, pentazocine, ethylketocyclazocine, U-50488H and clonidine in mice. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Clonidine; Cyclazocine; Ethylketocyclazocine; Female; Levorphanol; Male; Mice; Morphine; Narcotics; Pain; Pentazocine; Pyrrolidines	1987
Evaluation of the effects of opioid agonists and antagonists under a fixed-consecutive-number schedule in rats. Pharmacology, biochemistry, and behavior, 1987, Volume: 27, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Conditioning, Operant; Cyclazocine; Discrimination Learning; Ethylketocyclazocine; Male; Methadone; Morphine; Naloxone; Narcotics; Phenazocine; Pyrrolidines; Rats; Reinforcement Schedule	1987
Behavioral effects of a novel kappa opioid analgesic, U-50488, in rats and rhesus monkeys. Psychopharmacology, 1985, Volume: 85, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Cyclazocine; Discrimination, Psychological; Diuresis; Ethylketocyclazocine; Humans; Macaca mulatta; Male; Morphine; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains; Self Administration; Species Specificity; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors	1985
Kappa opiate receptor agonists: effects on behavior and on brain function and structure in rhesus monkeys. Biological psychiatry, 1984, Volume: 19, Issue:7 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Benzomorphans; Brain; Computers; Cyclazocine; Dose-Response Relationship, Drug; Electroencephalography; Ethylketocyclazocine; Evoked Potentials; Macaca mulatta; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa	1984
Opioid control of the ruminant stomach motility: functional importance of mu, kappa and delta receptors. Life sciences, 1984, Oct-22, Volume: 35, Issue:17 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Ethylketocyclazocine; Fentanyl; Gastrointestinal Motility; Morphine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sheep; Stomach	1984
Kappa opioid agonists and antagonists: effects on drinking and urinary output. Appetite, 1984, Volume: 5, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Butorphanol; Clonidine; Cyclazocine; Drinking; Ethylketocyclazocine; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Urination; Vasopressins	1984
Radioligands for probing opioid receptors. Journal of receptor research, 1984, Volume: 4, Issue:1-6 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Binding Sites; Brain; Cyclazocine; Diprenorphine; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naloxone; Pro-Opiomelanocortin; Protein Precursors; Pyrrolidines; Radioligand Assay; Rats; Receptors, Opioid; Vas Deferens	1984
Further study of kappa opioids on increased urination. The Journal of pharmacology and experimental therapeutics, 1983, Volume: 227, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Cyclazocine; Diuresis; Ethylketocyclazocine; Male; Morphinans; Naloxone; Narcotic Antagonists; Narcotics; Piperidines; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Urination	1983
Opioid receptor agonists in the rabbit colon: comparison of in vivo and in vitro studies. Life sciences, 1984, Oct-15, Volume: 35, Issue:16 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Colon; Cyclazocine; Dynorphins; Electric Conductivity; Enkephalins; Ethylketocyclazocine; Fentanyl; Male; Morphine; Naloxone; Narcotics; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	1984
Affinities of some common opioid analgesics towards four binding sites in mouse brain. Naunyn-Schmiedeberg's archives of pharmacology, 1984, Volume: 328, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Binding Sites; Brain; Codeine; Cyclazocine; Dextropropoxyphene; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Methionine; Ethylketocyclazocine; In Vitro Techniques; Membranes; Methadone; Mice; Models, Biological; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu	1984
Identification of benzomorphan-kappa opiate receptors in cerebral arteries which subserve relaxation. British journal of pharmacology, 1984, Volume: 82, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Cerebral Arteries; Cyclazocine; Dinoprost; Dogs; Drug Interactions; Ethylketocyclazocine; Female; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Phencyclidine; Prostaglandins F; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa	1984
The modulation of placental lactogen release by opioids: a role for extracellular calcium. Molecular and cellular endocrinology, 1993, Volume: 90, Issue:2 Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylate Cyclase Toxin; Analgesics; Calcium; Cells, Cultured; Dopamine; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; Gene Expression Regulation; Humans; Ionomycin; Naloxone; Naltrexone; Narcotics; Pertussis Toxin; Placental Lactogen; Pyrrolidines; Time Factors; Trophoblasts; Virulence Factors, Bordetella	1993
Brain and spinal cord kappa opiate receptors and pharmacological responses to U-50,488H in rats of differing ages. Pharmacology, biochemistry, and behavior, 1994, Volume: 48, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Aging; Analgesics; Animals; Binding, Competitive; Body Temperature; Brain; Brain Chemistry; Ethylketocyclazocine; Male; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Spinal Cord	1994
Opiate receptor agonists regulate phosphorylation of synapsin I in cocultures of rat spinal cord and dorsal root ganglion. Proceedings of the National Academy of Sciences of the United States of America, 1993, May-01, Volume: 90, Issue:9 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Cell Communication; Cells, Cultured; Colforsin; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Ganglia, Spinal; Isoproterenol; Kinetics; Male; Morphine; Naloxone; Neurons; Phosphates; Phosphoproteins; Phosphorylation; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid; Serotonin; Spinal Cord; Synapsins; Synaptosomes	1993
Discriminative-stimulus effects of the low efficacy mu agonist nalbuphine. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Discrimination, Psychological; Dose-Response Relationship, Drug; Ethylketocyclazocine; Male; Nalbuphine; Nalorphine; Naltrexone; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Self Administration	1993
Pharmacologic characteristics of a medullary hyperalgesic center. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Ethylketocyclazocine; Female; Hyperalgesia; Medulla Oblongata; Morphine; Nicotine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex	1993
Effects of acute and chronic administration of dizocilpine on the pharmacological responses to U-50,488H and brain and spinal cord kappa-opioid receptors in the rat. Pharmacology, 1995, Volume: 51, Issue:5 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Animals; Body Temperature; Body Weight; Brain Chemistry; Dizocilpine Maleate; Ethylketocyclazocine; Excitatory Amino Acid Antagonists; In Vitro Techniques; Kinetics; Male; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Spinal Cord	1995
Effects of kappa opioids on cocaine self-administration by rhesus monkeys. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 282, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Circadian Rhythm; Cocaine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Female; Macaca mulatta; Male; Naloxone; Naltrexone; Pyrrolidines; Receptors, Opioid, kappa; Self Administration; Substance-Related Disorders	1997
Establishing morphine and U-50,488H as discriminative stimuli in a three-choice assay with pigeons. Experimental and clinical psychopharmacology, 1998, Volume: 6, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Columbidae; Dextroamphetamine; Discrimination Learning; Discrimination, Psychological; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Ethylketocyclazocine; Generalization, Response; Morphine; Naltrexone; Narcotic Antagonists; Narcotics	1998
Receptor-mediated activation of G-proteins by kappa opioid agonists in frog (Rana esculenta) brain membranes. Brain research bulletin, 1998, Mar-15, Volume: 45, Issue:5 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Brain; Cell Membrane; Ethylketocyclazocine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Naltrexone; Narcotic Antagonists; Rana esculenta; Receptors, Opioid, kappa	1998
Differential antagonism of the rate-decreasing effects of kappa-opioid receptor agonists by naltrexone and norbinaltorphimine. European journal of pharmacology, 1999, Jul-14, Volume: 377, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Benzeneacetamides; Benzofurans; Benzomorphans; Conditioning, Operant; Dose-Response Relationship, Drug; Ethylketocyclazocine; Nalorphine; Naltrexone; Narcotic Antagonists; Pyrroles; Pyrrolidines; Receptors, Opioid, kappa; Reinforcement Schedule; Saimiri; Thiophenes	1999
Effects of kappa opioid agonists on the discriminative stimulus effects of cocaine in rhesus monkeys. Experimental and clinical psychopharmacology, 1999, Volume: 7, Issue:4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Cocaine; Discrimination Learning; Discrimination, Psychological; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Ethylketocyclazocine; Macaca mulatta; Male; Naloxone; Narcotic Antagonists; Receptors, Opioid, kappa; Salicylamides	1999
Diazabicyclononanones, a potent class of kappa opioid analgesics. Farmaco (Societa chimica italiana : 1989), 2002, Volume: 57, Issue:7 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Brain; Carboxylic Acids; Ethylketocyclazocine; Models, Molecular; Molecular Structure; Pyridines; Quantitative Structure-Activity Relationship; Rats; Receptors, Opioid, kappa	2002
Differential effects of opioid agonists on G protein expression in CHO cells expressing cloned human opioid receptors. Brain research bulletin, 2008, Sep-05, Volume: 77, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Benzamides; Blotting, Western; CHO Cells; Cricetinae; Cricetulus; Diterpenes, Clerodane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Female; Furans; Gene Expression; GTP-Binding Protein alpha Subunits, G12-G13; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Morphine; Oligopeptides; Piperazines; Pyrones; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	2008
Drug discrimination in pigeons trained to discriminate among morphine, U50488, a combination of these drugs, and saline. Behavioural pharmacology, 2011, Volume: 22, Issue:5-6 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Butorphanol; Columbidae; Discrimination Learning; Dose-Response Relationship, Drug; Ethylketocyclazocine; Male; Morphine; Naltrexone; Narcotic Antagonists; Pentazocine; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reinforcement Schedule; Sodium Chloride	2011