ethylketocyclazocine has been researched along with cyclazocine in 426 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 407 (95.54) | 18.7374 |
| 1990's | 18 (4.23) | 18.2507 |
| 2000's | 1 (0.23) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Coale, EH; Hein, DW; Herling, S; Valentino, RJ; Woods, JH | 2 |
| Eades, CG; Gilbert, PE; Huppler, RE; Martin, WR; Thompson, JA | 1 |
| Kuhar, MJ; Wamsley, JK; Zarbin, MA | 1 |
| Craft, RM; Dykstra, LA | 1 |
| Bem, WT; Coscia, CJ; Johnson, FE; Mamone, JY; Rush, MD; Szücs, M; Thomas, GE | 1 |
| Shea-Donohue, T; Touzeau, PL | 1 |
| Kornetsky, C; Pollock, J | 1 |
| Hoss, W; Periyasamy, S | 1 |
| Bartness, TJ; Billington, CJ; Herman, BH; Levine, AS; Morley, JE | 1 |
| Bettaney, J; Dray, A; James, IF; Ketchum, SB; Perkins, MN | 1 |
| Hanissian, SH; Tejwani, GA | 1 |
| LoPresti, D; Porreca, F; Ward, SJ | 1 |
| Doty, P; Dykstra, LA; Mattox, SR; Negus, SS; Picker, MJ | 1 |
| Magnan, J; Tiberi, M | 2 |
| Edwards, M; Gent, JP; Goodchild, CS; Serrao, JM | 1 |
| Cicero, TJ; Giordano, AL; Nock, B; O'Connor, LH | 1 |
| Goldberg, SR; Schindler, CW; White, MF | 1 |
| Barnette, MS; Barone, FC; Callahan, JF; Grous, M; Manning, CD | 1 |
| Clark, WC; Haertzen, CA; Janal, MN; Kumor, KM | 1 |
| Goldberg, SR; Katz, JL; Schindler, CW; Su, TP; Wu, XZ | 1 |
| Chahl, LA | 1 |
| Balster, RL | 1 |
| Ahmed, MS; Cavinato, AG; Maulik, D; Zhou, DH | 1 |
| deGroat, WC; Hisamitsu, T; Nagel, J; Roppolo, JR; Thor, KB; Tuttle, P | 1 |
| Holtzman, SG | 2 |
| Fedynyshyn, JP; Kwiat, G; Lee, NM | 1 |
| Dougall, IG; Leff, P | 2 |
| Bhargava, HN; Gulati, A; Ramarao, P | 3 |
| Craft, RM; Dykstra, LA; Picker, MJ | 1 |
| Benyhe, S; Farkas, T; Wollemann, M | 1 |
| Ho, BY; Takemori, AE | 1 |
| Bueno, L; Gué, M; Junien, JL | 1 |
| Allgaier, C; Daschmann, B; Hertting, G; Sieverling, J | 1 |
| DiBona, GF; Jones, SY; Kapusta, DR | 1 |
| Brantl, V; Liebmann, C; Schrader, U | 1 |
| Bykov, V; De Costa, BR; France, CP; Jacobson, AE; Rice, KC; Rothman, RB; Woods, JH | 1 |
| Clark, JA; Edelson, M; Hersh, B; Liu, L; Pasternak, GW; Price, M | 1 |
| Cornfeldt, M; Fielding, S; Gorney, B; Locke, KW | 1 |
| Bhargava, HN; Ramarao, P | 1 |
| Doty, P; Dykstra, LA; Picker, MJ | 1 |
| Blake, JW; DeQuick, D; Kamerling, S; Tai, C; Tobin, T; Weckman, TJ; Wood, T | 1 |
| Ford-Rice, F; London, ED; Ori, C | 1 |
| Hirobe, M; Konno, F; Takayanagi, I; Toru, T | 1 |
| Garzon, J; Landahl, HD; Lee, NM | 1 |
| Dykstra, LA; Picker, MJ | 1 |
| Dick, W; Jakob, H; Mertzlufft, F; Nawrath, H; Rupp, J; Sack, U | 1 |
| Martin, WR; Wu, KM | 2 |
| Rauch, RJ; Stephenson, JD; Stolerman, IP | 1 |
| Bronson, ME; Moerschbaecher, JM | 1 |
| Kameyama, T; Ukai, M | 1 |
| Deviche, P; Moore, FL | 1 |
| Nunan, L; Porreca, F; Sheldon, RJ | 1 |
| Bertalmio, AJ; Woods, JH | 1 |
| Brocklehurst, C; Devia, C; Faust, WB; Moerschbaecher, JM | 1 |
| Frey, EA; Jacobson, AE; Rice, KC; Tocque, B | 1 |
| De Souza, EB; Kuhar, MJ; Schmidt, WK | 1 |
| Dykstra, LA; Massie, CA; Picker, M | 1 |
| Imai, T; Kamikubo, K; Miura, K; Miura, Y; Miyashita, T; Murase, H; Nakamura, S; Niwa, M; Satoh, T; Tomita, A | 1 |
| Friedmann, T; Furst, S; Kovacs, A; Wagner, T | 1 |
| Burks, TF; Fox, DA | 1 |
| Larson, DL; Lipkowski, AW; Nagase, H; Portoghese, PS; Takemori, AE | 1 |
| Cameron, DP; Ma, A; Ma, V | 1 |
| Bowen, WD; Copeland, CF; Kooper, GN; Levinson, NR | 1 |
| Ishizuka, Y; Oka, T | 1 |
| Bertelli, GM; Borea, PA; Gilli, G | 1 |
| Junien, JL; Pascaud, X; Roman, F; Vauché, D | 1 |
| Cicero, TJ; Nock, B; O'Connor, LH; Rajpara, A | 2 |
| Clark, JA; Pasternak, GW | 1 |
| Nagase, H; Portoghese, PS; Takemori, AE | 1 |
| Cowan, A; Gmerek, DE | 3 |
| Ho, BY; Naeseth, JS; Portoghese, PS; Takemori, AE | 1 |
| Dykstra, LA; Massie, CA | 1 |
| Caudill, A; Condon, RE; Szurszewski, JH; Telford, GL | 1 |
| Goodrich, JE; Katz, JL; Solomon, RE | 1 |
| Magnan, J; Mongeau, R; Payette, P; Tiberi, M | 1 |
| Dashwood, MR; Muddle, JR; Spyer, KM | 1 |
| Su, TP | 1 |
| Moises, HC; Walker, JM | 1 |
| Carino, MA; Horita, A; Yamawaki, S | 1 |
| Ludens, JH; Slizgi, GR | 3 |
| Way, EL; Yamasaki, Y | 1 |
| Herz, A; Schiller, PW; Schulz, R; Shearman, GT | 1 |
| Bicknell, RJ; Chapman, C; Leng, G | 1 |
| Bryant, HU; Lowy, MT; Malven, PV; Steele, TD; Yim, GK | 1 |
| Martin, WR; Wettstein, JG | 1 |
| Falke, NE; Fischer, EG; Martin, R | 1 |
| Cooper, SJ; Jackson, A; Kirkham, TC | 1 |
| Cho, N; Hirobe, M; Koike, K; Konno, F; Okumura, K; Takayanagi, I | 1 |
| Dequick, DJ; Kamerling, SG; Tobin, T; Weckman, TJ | 1 |
| Illes, P; Ramme, D | 1 |
| Geppert, M; Illes, P; Jackisch, R | 1 |
| Buder, M; Fuder, H; Riers, HD; Rothacher, G | 1 |
| Brenner, AS; Geppert, M; Illes, P; Jackisch, R | 1 |
| Kirby, GC; McQueen, DS | 1 |
| Baskin, DS; Hosobuchi, Y; Kuroda, H; Lee, NM; Loh, HH; Matsui, T | 1 |
| Hong, O; Khazan, N; Young, G | 1 |
| Burks, TF; Deupree, D; Hruby, V; Hsiao, S; Mosberg, HI; Porreca, F; Spencer, RL | 1 |
| Cho, N; Hirobe, M; Kobayashi, C; Konno, F; Morimoto, R; Takayanagi, I | 1 |
| Inoki, R; Kudo, T; Ohkubo, T; Shibata, M; Takahashi, H | 1 |
| Hong, O; Khazan, N; Young, GA | 1 |
| Illes, P; Ramme, D; Späth, L; Starke, K | 1 |
| Lipkowski, AW; Portoghese, PS; Takemori, AE | 1 |
| Itoh, Y; Nishibori, M; Oishi, R; Saeki, K | 1 |
| Russell, NJ; Schaible, HG; Schmidt, RF | 1 |
| Schmauss, C | 1 |
| Dickenson, AH; Knox, RJ | 1 |
| Katz, JL | 1 |
| Bhargava, HN; Das, S | 3 |
| Benyhe, S; Borsodi, A; Hepp, J; Khan, A; Medzihradszky, K; Simon, J; Szücs, M; Wollemann, M | 1 |
| Inoki, R; Maeda, S; Nakamae, J | 2 |
| Dubner, R; Hargreaves, KM; Joris, JL | 1 |
| Barchfeld-Rothschild, CC; Medzihradsky, F | 1 |
| Belisle, S; Bellabarba, D; Gallo-Payet, N; Lehoux, JG; Lemaire, S; Petit, A | 1 |
| London, ED; Ori, C; Su, TP; Weissman, AD | 1 |
| Cruciani, RA; Gainer, H; Lang, MA; Pesce, GO; Rodbard, D; Russell, JT | 1 |
| Furukawa, H; Hiramatsu, M; Kameyama, T; Nabeshima, T | 1 |
| Buéno, L; Gué, M; Hondé, C; Junien, JL; Pascaud, X | 1 |
| Cooper, SJ; Jackson, A | 2 |
| Bryant, HU; Malven, PV; Steele, TD; Yim, GK | 1 |
| Bianchi, C; Siniscalchi, A | 1 |
| Alvinerie, M; Bueno, L; Gue, M; Honde, C; Junien, JL; Pascaud, X | 1 |
| Goodman, SR; McLaughlin, PJ; Zagon, IS | 1 |
| Borsodi, A; Lajtha, A; Zawilska, J | 1 |
| Kumar, S; Martin, WR; Sloan, JW | 1 |
| Candeletti, S; Cavicchini, E; Ferri, S; Romualdi, P; Spampinato, S; Speroni, E | 1 |
| Abbott, FV | 1 |
| Berzetei, IP; Duckles, SP; Fong, A; Yamamura, HI | 1 |
| Limberger, N; Späth, L; Starke, K | 1 |
| Limberger, N; Singer, EA; Starke, K | 1 |
| Agbas, A; Avni Oktem, H; Borsodi, A; Simon, J; Varga, E | 1 |
| Adler, MW; Geller, EB; Rowan, CH | 1 |
| George, R; Pechnick, R; Poland, RE | 2 |
| Hirst, M; Kavaliers, M | 2 |
| Coscia, CJ; Roth, BL; Spain, JW | 1 |
| Portoghese, PS; Takemori, AE | 2 |
| Boublik, J; Funder, JW; Jefferys, D | 1 |
| Hammonds, RG; Ho, CL; Li, CH | 1 |
| Ensinger, HA | 2 |
| Benyhe, S; Borsodi, A; Simon, J; Szücs, M; Wollemann, M | 1 |
| Adler, MW; Geller, EB; Kirby, A; Messner, S; Robin, M | 1 |
| Mack, KJ; Weyhenmeyer, JA | 1 |
| Dixon, WR; Gaddis, RR | 1 |
| Neil, A | 2 |
| Tam, SW | 2 |
| Burks, TF; Hirning, LD; Porreca, F | 1 |
| Lee, MF; Mack, KJ; Weyhenmeyer, JA | 1 |
| Hayes, A; Kelly, A | 1 |
| Brown, SR; Cox, BM; Werling, LL; Zarr, GD | 2 |
| Holford, NH; Rosenbaum, JS; Sadée, W | 1 |
| Eisenberg, RM | 2 |
| Dewar, D; Jenner, P; Marsden, CD | 2 |
| Bunn, SJ; Hanley, MR; Wilkin, GP | 1 |
| Krall, S; Lynch, WC; Paden, CM; Watt, J | 1 |
| Grace, M; Kneip, J; Levine, AS; Morley, JE; Shearman, GT; Zeugner, H | 1 |
| Boudouresque, F; Bourhim, N; Cantau, P; Castanas, E; Giraud, P; Oliver, C | 1 |
| Bucarelli, A; De Montis, MG; Devoto, P; Tagliamonte, A | 1 |
| Gosnell, BA; Levine, AS; Morley, JE; Waggoner, DW | 1 |
| DeRossett, SE; Holtzman, SG | 2 |
| Kitchen, I; McDowell, J | 1 |
| Kameyama, T; Matsuno, K; Nabeshima, T | 1 |
| Hirobe, M; Konno, F; Sato, Y; Takayanagi, I; Togashi, K | 1 |
| Cantau, P; Castanas, E; Giraud, P; Gunz, G; Jaquet, P | 1 |
| Khazan, N; Young, GA | 7 |
| Annefors, S; Neil, A | 1 |
| Barber, DJ; Cooper, SJ; Jackson, A; Moores, WR | 1 |
| Bidlack, JM; Denton, RR | 1 |
| Malone, MH; Matos, FF | 1 |
| Bell, RD; Cicero, TJ | 1 |
| Bettermann, R; Illes, P | 1 |
| Aoki, K; Ishii, K; Kajiwara, M; Matsumiya, T; Numata, H; Oka, T | 1 |
| Itzhak, Y; Pasternak, GW | 1 |
| Glasel, JA; Myers, WE | 1 |
| Hirst, M; Kavaliers, M; Rangeley, RW; Teskey, GC | 1 |
| Cros, J; Gouardères, C; Kopp, N; Quirion, R | 1 |
| Mansour, A; Valenstein, ES | 1 |
| Kamei, H; Kameyama, T; Matsuno, K; Nabeshima, T | 1 |
| Su, TP; Weissman, AD; Yeh, SY | 1 |
| Fischel, SV; Medzihradsky, F | 1 |
| Simon, EJ | 1 |
| Faden, AI; Krumins, SA | 1 |
| Hiramatsu, M; Kameyama, T; Nabeshima, T | 2 |
| Ahmed, MS; Horst, MA | 1 |
| Brown, SR; Cote, TE; Cox, BM; Puttfarcken, P; Werling, LL | 1 |
| Brown, SR; Cox, BM; Puttfarcken, P; Werling, LL | 1 |
| Hayes, AG; Skingle, M; Tyers, MB | 1 |
| Haertzen, CA; Jasinski, D; Johnson, RE; Kocher, T; Kumor, KM | 1 |
| Larson, DL; Portoghese, PS; Ronsisvalle, G; Takemori, AE | 1 |
| Goldberg, S; Haertzen, C; Johnson, RE; Kumor, K; Su, TP; Vaupel, B | 1 |
| Seelhorst, A; Starke, K | 1 |
| Hölting, T; Starke, K | 1 |
| Barr, GA; Erickson, KL; Paredes, W; Zukin, RS | 1 |
| Liu-Chen, LY; Tam, SW | 1 |
| Abbott, FV; Franklin, KB; Libman, RB | 1 |
| Hölting, T; Limberger, N; Späth, L; Starke, K | 1 |
| Bakalkin, GIa; Iarygin, KN; Kobylianskiĭ, AG; Nesterenko, PN; Pivovarov, AS | 1 |
| Dykstra, LA; Slifer, BL | 1 |
| Kornetsky, C; Sasson, S; Unterwald, E | 1 |
| Barr, GA; Giordano, J | 2 |
| Poncet, J; Reny-Palasse, V; Rips, R | 1 |
| Hynes, MD; Leander, JD; Reel, JK; Zimmerman, DM | 1 |
| Gardner, EL; Vaysse, PJ; Zukin, RS | 1 |
| Portoghese, PS; Schoenecker, JW; Takemori, AE | 1 |
| Bagley, RB; Compton, DR; Katzen, JS; Martin, BR | 1 |
| Krumins, SA | 1 |
| Kadlec, O; Masek, K; Sebestová, L; Seferna, I | 1 |
| Catt, KJ; Dufau, ML; Stojilković, SS | 1 |
| Kadlec, O; Masek, K; Seferna, I | 1 |
| Gosnell, BA; Levine, AS; Morley, JE; Romsos, DR | 2 |
| Hart, JC; Leander, JD; Zerbe, RL | 1 |
| Delay-Goyet, P; Roques, BP; Zajac, JM | 1 |
| Fujii, A; Ishizuka, Y; Kenjo, T; Oka, T | 1 |
| Lovett, JA; Portoghese, PS | 1 |
| Calcagnetti, DJ; Cramer, CP; Fanselow, MS; Helmstetter, FJ | 1 |
| Haertzen, CA; Jasinski, DR; Johnson, RE; Kumor, KM | 1 |
| Benyhe, S; Wollemann, M | 1 |
| Bunn, SJ; Wilkin, GP | 1 |
| Donahoe, J; Kamerling, S; Tobin, T; Weckman, T | 1 |
| Dykstra, LA; Gmerek, DE; Winger, G; Woods, JH | 1 |
| Dykstra, LA; Gmerek, DE; Woods, JH | 1 |
| Maher, TJ; Moya-Huff, FA | 1 |
| Gormezano, I; Harvey, JA; Schindler, CW | 1 |
| Dykstra, LA; Picker, M | 1 |
| Ishihara, K; Iwama, T; Satoh, M; Takagi, H | 1 |
| Baragatti, G; Caron, F; Gavend, MM; Gavend, MR; Pastrello, D; Serre-Debeauvais, F | 1 |
| Brocklehurst, C; Devia, C; Moerschbaecher, JM | 1 |
| Michaux, K; Monroe, PJ; Smith, DJ | 1 |
| Goldberg, SR; Katz, JL | 1 |
| Gormezano, I; Harvey, JA; Lamb, MR; Schindler, CW | 1 |
| Spoerlein, MT; Szewczak, MR | 1 |
| Bradford, HF; White, EJ | 1 |
| Blackburn, TP; Borkowski, KR; Friend, J; Rance, MJ | 1 |
| Belknap, JK; Danielson, PW; Laursen, SE; Noordewier, B | 1 |
| Dykstra, LA; Heise, JW; Picker, M | 1 |
| Beck, T; Krieglstein, J | 1 |
| Buchwald, WD; Cone, EJ; Kumor, K; Yousefnejad, D | 1 |
| Costa, T; Dunn, LL; Hubbell, CL; Hunter, GA; Reid, LD | 1 |
| Bardon, T; Ruckebusch, Y | 1 |
| Collins, RJ; Tang, AH | 1 |
| Bergman, J; Hassoun, J; Schuster, CR | 1 |
| Levine, AS; Morley, JE; Wager-Srdar, S | 1 |
| Cooper, SJ; Turkish, S | 1 |
| Fitzjarrell, AT; Heath, RG; Walker, CF | 1 |
| Bardon, T; Pairet, M; Ruckebusch, Y | 1 |
| Leander, JD | 5 |
| Berry, SC; Dawkins, SL; Lodge, D | 1 |
| Garzón, J; Lee, NM; Sánchez-Blázquez, P | 1 |
| Domino, EF; Gwynn, GJ | 2 |
| Loh, HH; Stokes, KB | 1 |
| Hill, HF; Shibuya, T; Watanabe, Y | 1 |
| Bryant, HU; Malven, PV; Yim, GK | 1 |
| Ensinger, H; Hedler, L; Schurr, C; Starke, K | 1 |
| Gosnell, BA; Levine, AS; Morley, JE | 3 |
| Huidobro-Toro, JP; Parada, S | 1 |
| Corbett, AD; Gillan, MG; Kosterlitz, HW; McKnight, AT; Paterson, SJ; Robson, LE | 1 |
| Aceto, MD | 1 |
| Buchan, P; Smith, TW | 1 |
| Adler, MW; Cowan, A; Tortella, FC | 1 |
| Huidobro-Toro, JP; Lee, NM; Loh, HH; Way, EL; Yoshimura, K | 3 |
| Rackham, A; Richard, J; Wood, PL | 1 |
| Cros, J; Porthé, G; Valette, A | 1 |
| Herz, A; Pfeiffer, A | 2 |
| Dawson, G; McLawhon, RW; Miller, RJ; West, RE | 2 |
| Dickinson, SL; Slater, P | 1 |
| Cabbat, FS; Heikkila, RE; Manzino, L | 1 |
| Zukin, RS; Zukin, SR | 1 |
| Chavkin, C; Goldstein, A; James, IF | 1 |
| Miller, RJ | 1 |
| Hein, DW; Herling, S; Nemeth, MA; Valentino, RJ; Woods, JH | 1 |
| Charleson, S; Wood, PL | 1 |
| Piercey, MF; Schroeder, LA; Varner, K | 1 |
| Ben-Sreti, MM; Sewell, RD | 1 |
| Cowan, A; Porreca, F; Raffa, RB; Tallarida, RJ | 4 |
| Tung, AS; Yaksh, TL | 1 |
| Goodman, RR; Snyder, SH | 1 |
| Huidobro-Toro, JP; Way, EL; Yoshimura, K | 1 |
| Garzón, J; Jen, MF; Lee, NM | 1 |
| Sewell, RD; Spencer, PS; Upton, N | 1 |
| Herz, A | 1 |
| Ben-Sreti, MM; Gonzalez, JP; Sewell, RD | 1 |
| Lee, NM | 1 |
| Kamerling, SG; Martin, WR; Wettstein, JG; Wu, KM | 2 |
| Huidobro-Toro, JP; Lee, NM; Loh, HH; Way, EL; Zhu, YX | 1 |
| Arnone, M; Bachy, A; Boigegrain, R; Gout, B; Morre, M; Roncucci, R | 1 |
| Pert, CB; Quirion, R; Weiss, AS | 1 |
| Bennett, DB; Coscia, CJ; Roth, BL; Spain, JW | 1 |
| Cros, J; Pontonnier, G; Porthe, G; Tafani, M; Valette, A | 1 |
| Jacob, J; Michaud, G; Nicola, MA; Prudhomme, N | 1 |
| Fujibayashi, K; Iwama, T; Kubota, A; Satoh, M; Takagi, H; Wada, T; Yasui, M | 1 |
| Enger, M; Grynne, BH; Holmen, AT; Maurset, AR | 1 |
| Dahlstrom, PJ; Fischel, SV; Medzihradsky, F; Mitsos, SE; Woods, JH | 1 |
| Garzón, J; Gerhart, J; Lee, NM; Loh, HH; Sánchez-Blázquez, P | 1 |
| Billington, CJ; Gerritsen, GC; Levine, AS; Morley, JE | 1 |
| Gautret, B; Schmitt, H | 1 |
| Pairet, M; Ruckebusch, Y | 1 |
| Rezvani, A; Way, EL | 1 |
| Hymson, DL; Hynes, MD | 1 |
| Gosnell, BA; Grace, M; Kneip, J; Levine, AS; Morley, JE | 2 |
| Stephens, KR; Young, AM | 1 |
| Han, JS; Xie, GX | 2 |
| Burkard, WP; Flück, N; Müller, PM | 1 |
| Livingston, A; Morris, B | 1 |
| Hylden, JL; Wilcox, GL | 1 |
| Hiller, JM; Simon, EJ | 1 |
| Pasternak, GW | 1 |
| Akkerman, AM; Bakel, HC; Büscher, H; Hill, RC; Maurer, R; Petcher, TJ; Römer, D; Welle, HB | 1 |
| Chang, KJ; Cuatrecasas, P; Hazum, E | 1 |
| Holtzman, SG; Teal, JJ | 1 |
| Lajtha, A; Reith, ME; Sershen, H | 1 |
| Gähwiler, BH; Maurer, R | 1 |
| Kosterlitz, HW; Paterson, SJ; Robson, LE | 1 |
| Lajtha, A; Reith, ME; Sershen, H; Vadasz, C | 1 |
| Fujino, M; Negishi, K; Oka, T; Sawa, A; Suda, M; Wakimasu, M | 1 |
| Herz, A; Shearman, GT | 3 |
| Audigier, Y; Cros, J; Gouardéres, C | 1 |
| Harris, RA; Snell, D | 1 |
| Nishimura, S; Pasternak, GW; Wolozin, BL | 1 |
| Ishizuka, Y; Kajiwara, M; Matsumiya, T; Negishi, K; Oka, T; Watanabe, Y | 1 |
| Bajusz, S; Berzétei, IP; Hársing, LG; Rónai, AZ; Vizi, ES | 1 |
| Itzhak, Y; Keren, O; Sarne, Y | 1 |
| Bonnet, KA; Carr, KD; Simon, EJ | 1 |
| Nishimura, S; Pasternak, GW | 1 |
| Guidotti, A; Saiani, L | 1 |
| Bearden, LJ; Snead, OC | 1 |
| Portoghese, PS; Takemori, AE; Ward, SJ | 1 |
| Takemori, AE; Ward, SJ | 1 |
| Grace, M; Kniep, J; Levine, AS; Morley, JE | 1 |
| Attali, B; Audigier, Y; Cros, J; Gouardères, C; Mazarguil, H | 1 |
| Hirst, M; Tepperman, FS | 1 |
| Brown, DR; Holtzman, SG; Locke, KW | 1 |
| Kandasamy, SB; Williams, BA | 1 |
| Bowen, WD; Herkenham, M; Pert, CB; Quirion, R | 1 |
| Curtis, MT; Lefer, AM | 1 |
| Cicero, TJ; Meyer, ER; Owens, DP; Schmoeker, PF | 1 |
| Johnson, N; Pasternak, GW | 1 |
| Grace, M; Kneip, J; Levine, AS; Morley, JE; Zeugner, H | 1 |
| Boublik, JH; Clements, JA; Funder, JW; Herington, AC | 1 |
| Ahmed, MS | 1 |
| Kattau, RW; Leander, JD; Rathbun, RC | 1 |
| Hayes, AG; Tyers, MB | 1 |
| Code, RA; Tang, AH | 1 |
| Hill, HF; Salafsky, B; Shibuya, T; Watanabe, Y | 1 |
| Laurent, S; Schmitt, H | 2 |
| Killian, A; Mack, KJ; Weyhenmeyer, JA | 1 |
| Altura, BM; Altura, BT; Quirion, R | 1 |
| Bajorek, JG; Lee, RJ; Lomax, P | 1 |
| Holtzman, SG; White, JM | 1 |
| Kameyama, T; Nabeshima, T; Yamada, K | 1 |
| Levine, AS; Morley, JE | 1 |
| Dykstra, LA | 2 |
| Johnson, KM; Leventer, SM | 1 |
| Goldstein, A; Han, JS; Xie, GX | 1 |
| Mastropaolo, J; Moerschbaecher, JM; Thompson, DM; Winsauer, PJ | 1 |
| Herling, S; Solomon, RE; Valentino, RJ; Woods, JH | 1 |
| Lowy, MT; Yim, GK | 1 |
| Aleman, DO; Carr, KD; Holland, MJ; Simon, EJ | 1 |
| Commissaris, RL; Henck, JW; Mokler, DJ; Rech, RH | 1 |
| Haertzen, CA; Henningfield, JE; Hickey, JE; Jasinski, DR; Johnson, RE; Kumor, K | 1 |
| Kitchen, I | 1 |
| Chaillet, P; Costentin, J; Marçais-Collado, H | 1 |
| Colpaert, FC; Janssen, PA | 1 |
| Isaacson, RL; Lanthorn, TH | 1 |
| Iwamoto, ET | 1 |
| Herling, S; Woods, JH | 1 |
| McCarthy, PS; Sanger, DJ | 1 |
| Dykstra, LA; Milar, KS | 1 |
| Moerschbaecher, JM; Thompson, DM | 1 |
| Harris, DW; Sethy, VH | 1 |
| Hein, DW; Herling, S; Woods, JH; Young, AM | 1 |
| Herling, S; Woods, JH; Young, AM | 1 |
| Bidlack, JM; Cohen, DJ; Kucejko, R; Lou, R; Parkhill, AL; VanAlstine, M; Wentland, MP | 1 |
6 review(s) available for ethylketocyclazocine and cyclazocine
| Article | Year |
|---|---|
Narcotic analgesics, their detection and pain measurement in the horse: a review.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Butorphanol; Chromatography, Thin Layer; Cyclazocine; Ethylketocyclazocine; Etorphine; Fentanyl; Horses; Morphine; Pain Measurement; Pentazocine; Pyrrolidines; Radioimmunoassay; Receptors, Opioid | 1989 |
Classification of opioid and 5-hydroxytryptamine receptors by means of discriminative drug effects.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Conditioning, Classical; Cyclazocine; Discrimination Learning; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Lysergic Acid Diethylamide; Narcotics; Nicotine; Piperazines; Pyrimidines; Receptors, Opioid; Receptors, Serotonin; Research Design; Tetrahydronaphthalenes | 1987 |
Endorphins and food intake: kappa opioid receptor agonists and hyperphagia.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzodiazepines; Benzomorphans; Butorphanol; Choice Behavior; Cyclazocine; Diuresis; Drinking; Dynorphins; Eating; Endorphins; Ethylketocyclazocine; Humans; Morphine; Narcotic Antagonists; Phenazocine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Satiety Response | 1985 |
Recent studies on opioid receptors: heterogeneity and purification.
Topics: Alcohols; Animals; Brain Chemistry; Centrifugation, Density Gradient; Chromatography, Affinity; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Ethylmaleimide; Humans; Lectins; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, Phencyclidine; Solubility; Tritium; Wheat Germ Agglutinins | 1986 |
Multiple opiate receptors for multiple opioid peptides.
Topics: Animals; beta-Endorphin; Brain; Cyclazocine; Dogs; Drug Tolerance; Dynorphins; Endorphins; Ethylketocyclazocine; Male; Mice; Morphine; Naloxone; Neuromuscular Junction; Phenazocine; Rabbits; Radioligand Assay; Rats; Receptors, Opioid; Synaptic Transmission | 1982 |
Multiple opiate receptors and their functional significance.
Topics: Animals; beta-Endorphin; Brain; Cyclazocine; Dynorphins; Endorphins; Enkephalins; Ethylketocyclazocine; Morphine; Receptors, Opioid; Tissue Distribution | 1983 |
3 trial(s) available for ethylketocyclazocine and cyclazocine
| Article | Year |
|---|---|
Multidimensional scaling of subjective judgements of drug similarities among ketocyclazocine, morphine, cyclazocine, naloxone and placebo.
Topics: Adult; Cyclazocine; Ethylketocyclazocine; Generalization, Stimulus; Humans; Male; Models, Psychological; Morphine; Naloxone | 1990 |
Human psychopharmacology of ketocyclazocine as compared with cyclazocine, morphine and placebo.
Topics: Adult; Blood Pressure; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Euphoria; Hallucinations; Humans; Male; Morphine; Placebos; Pupil; Receptors, Opioid; Receptors, Opioid, kappa; Substance-Related Disorders; Time Factors | 1986 |
The psychopharmacologic and prolactin response after large doses of naloxone in man.
Topics: Adult; Blood Pressure; Body Temperature; Cyclazocine; Discrimination, Psychological; Ethylketocyclazocine; Humans; Male; Models, Theoretical; Morphine; Naloxone; Prolactin; Pulse; Pupil; Respiration | 1988 |
417 other study(ies) available for ethylketocyclazocine and cyclazocine
| Article | Year |
|---|---|
Narcotic drug discriminations by rhesus monkeys and pigeons.
Topics: Animals; Columbidae; Cyclazocine; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Discrimination Learning; Dose-Response Relationship, Drug; Enkephalins; Ethylketocyclazocine; Etorphine; Hormones; Macaca; Macaca mulatta; Naltrexone; Narcotics; Phenazocine | 1979 |
The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.
Topics: Animals; Apomorphine; Cyclazocine; Cyclopropanes; Dextropropoxyphene; Dogs; Ethylketocyclazocine; Humans; Morphinans; Morphine; Morphine Dependence; Nalorphine; Naltrexone; Phenazocine; Spinal Cord | 1976 |
Anterograde transport of opioid receptors in rat vagus nerves and dorsal roots of spinal nerves: pharmacology and sensitivity to sodium and guanine nucleotides.
Topics: Animals; Axonal Transport; Colchicine; Cyclazocine; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guanosine Triphosphate; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Sodium Chloride; Spinal Nerve Roots; Vagus Nerve | 1990 |
Differential cross-tolerance to opioids in squirrel monkeys responding under a shock titration schedule.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Cyclazocine; Drug Tolerance; Electroshock; Ethylketocyclazocine; Male; Methadone; Morphine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri | 1990 |
Sigma and opioid receptors in human brain tumors.
Topics: Adenocarcinoma; Analgesics, Opioid; Animals; Astrocytoma; Brain Neoplasms; Cyclazocine; Ethylketocyclazocine; Glioblastoma; Glioma; Humans; Male; Mice; Mice, Nude; Neuroblastoma; Radioligand Assay; Rats; Receptors, Opioid; Receptors, sigma | 1990 |
Kappa agonists inhibit gastric emptying but not acid secretion in rhesus monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antihypertensive Agents; Cyclazocine; Dynorphins; Ethylketocyclazocine; Gastric Acid; Gastric Emptying; Macaca mulatta; Male; Narcotics; Peptide Fragments; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Sodium | 1990 |
Pharmacologic evidence for nociception resulting from noncontingent "rewarding" brain stimulation.
Topics: Analgesics, Opioid; Animals; Arousal; Cyclazocine; Dose-Response Relationship, Drug; Electric Stimulation; Escape Reaction; Ethylketocyclazocine; Hypothalamic Area, Lateral; Male; Medial Forebrain Bundle; Motivation; Naloxone; Nociceptors; Rats; Rats, Inbred F344; Receptors, Opioid; Sensory Thresholds | 1990 |
Kappa opioid receptors stimulate phosphoinositide turnover in rat brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Cyclazocine; Dynorphins; Enkephalins; Ethylketocyclazocine; Male; Phosphatidylinositols; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1990 |
Effects of the opiate antagonists diprenorphine and naloxone and of selected opiate agonists on feeding behavior in guinea pigs.
Topics: Animals; Butorphanol; Circadian Rhythm; Cyclazocine; Diprenorphine; Ethylketocyclazocine; Feeding Behavior; Guinea Pigs; Morphinans; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
Opioid receptor ligands in the neonatal rat spinal cord: binding and in vitro depression of the nociceptive responses.
Topics: Animals; Animals, Newborn; Benzeneacetamides; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Kinetics; Ligands; Morphine; Muscle, Smooth, Vascular; Naloxone; Narcotics; Nociceptors; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Spinal Cord | 1990 |
Modulation of mu, delta and kappa opioid receptors in rat brain by metal ions and histidine.
Topics: Animals; Brain Chemistry; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; Histidine; Kinetics; Male; Membranes; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sulfhydryl Reagents; Trace Elements; Zinc | 1990 |
Opioid agonist affinity in the guinea-pig ileum and mouse vas deferens.
Topics: Animals; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Ileum; Male; Methadone; Mice; Morphine; Morphine Derivatives; Naltrexone; Receptors, Opioid; Vas Deferens | 1990 |
Discriminative stimulus properties of U50,488 and morphine: effects of training dose on stimulus substitution patterns produced by mu and kappa opioid agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Cyclazocine; Discrimination Learning; Dose-Response Relationship, Drug; Ethylketocyclazocine; Fentanyl; Male; Methadone; Morphine; Naloxone; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
Demonstration of the heterogeneity of the kappa-opioid receptors in guinea-pig cerebellum using selective and nonselective drugs.
Topics: Animals; Benzeneacetamides; Benzomorphans; Binding, Competitive; Cerebellum; Computers; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Guinea Pigs; In Vitro Techniques; Kinetics; Male; Membranes; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
On the mechanism by which midazolam causes spinally mediated analgesia.
Topics: Analgesia, Epidural; Animals; Bicuculline; Cyclazocine; Dose-Response Relationship, Drug; Electric Stimulation; Ethylketocyclazocine; Fentanyl; Flumazenil; Male; Midazolam; Pain; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sensory Thresholds | 1990 |
Affinity of drugs and peptides for U-69,593-sensitive and -insensitive kappa opiate binding sites: the U-69,593-insensitive site appears to be the beta endorphin-specific epsilon receptor.
Topics: Analgesics; Animals; Benzeneacetamides; Binding, Competitive; Brain; Culture Techniques; Cyclazocine; Ethylketocyclazocine; Narcotics; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1990 |
Effects of morphine, ethylketocyclazocine, N-allylnormetazocine and naloxone on locomotor activity in the rabbit.
Topics: Animals; Cyclazocine; Ethylketocyclazocine; Female; Male; Morphine; Motor Activity; Naloxone; Nictitating Membrane; Phenazocine; Rabbits | 1990 |
Inhibition of neuronally induced relaxation of canine lower esophageal sphincter by opioid peptides.
Topics: Animals; Autonomic Nervous System; Cyclazocine; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dogs; Electric Stimulation; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Esophagogastric Junction; Ethylketocyclazocine; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth; Neurons; Phenazocine | 1990 |
Enhanced sensitivity to behavioral effects of naltrexone in rats.
Topics: Animals; Conditioning, Psychological; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Male; Morphine; Naloxone; Naltrexone; Rats; Salivation | 1990 |
Withdrawal responses of guinea-pig isolated ileum following brief exposure to opiates and opioid peptides.
Topics: Animals; Benzomorphans; Buprenorphine; Cyclazocine; Endorphins; Ethylketocyclazocine; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle, Smooth; Naloxone; Narcotics; Substance P; Substance Withdrawal Syndrome | 1986 |
Substitution and antagonism in rats trained to discriminate (+)-N-allylnormetazocine from saline.
Topics: Animals; Binding Sites; Butaclamol; Cyclazocine; Discrimination Learning; Ethylketocyclazocine; Haloperidol; Male; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1989 |
Opioid binding properties of the purified kappa receptor from human placenta.
Topics: Benzomorphans; Binding, Competitive; Chromatography; Cyclazocine; Electrophoresis, Polyacrylamide Gel; Ethylketocyclazocine; Etorphine; Humans; Molecular Weight; Naloxone; Narcotics; Placenta; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, kappa | 1989 |
Selective inhibitory effects of ethylketocyclazocine on reflex pathways to the external urethral sphincter of the cat.
Topics: Animals; Cats; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Female; Morphine; Naloxone; Oligopeptides; Receptors, Opioid; Receptors, Opioid, kappa; Reflex; Urethra; Urinary Bladder; Urinary Incontinence | 1989 |
Opioid- and phencyclidine-like discriminative effects of ditolylguanidine, a selective sigma ligand.
Topics: Animals; Benzomorphans; Cyclazocine; Discrimination Learning; Ethylketocyclazocine; Generalization, Psychological; Guanidines; Haloperidol; Levorphanol; Male; Naltrexone; Narcotics; Phencyclidine; Rats; Receptors, Opioid; Receptors, sigma; Stereoisomerism | 1989 |
Characterization of high affinity opioid binding sites in rat periaqueductal gray P2 membrane.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Male; Membranes; Periaqueductal Gray; Pyrrolidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid | 1989 |
Estimation of affinities and efficacies for kappa-receptor agonists in guinea-pig ileum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Binding, Competitive; Cyclazocine; Electric Stimulation; Ethylketocyclazocine; Guinea Pigs; In Vitro Techniques; Male; Models, Biological; Morphinans; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa | 1989 |
Effects of morphine in rats treated chronically with U-50,488 H, a kappa opioid receptor agonist.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Binding, Competitive; Brain Chemistry; Catalepsy; Cyclazocine; Drug Tolerance; Ethylketocyclazocine; Male; Membranes; Morphine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Spinal Cord; Time Factors | 1989 |
Differential cross-tolerance to opioid agonists in morphine-tolerant pigeons responding under a schedule of food presentation.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Chlorpromazine; Columbidae; Conditioning, Operant; Cyclazocine; Dose-Response Relationship, Drug; Drug Tolerance; Ethylketocyclazocine; Female; Morphine; Pyrrolidines; Receptors, Opioid | 1989 |
Effect of sodium on [3H]ethylketocyclazocine binding to opioid receptors in frog brain membranes.
Topics: Animals; Brain; Cyclazocine; Ethylketocyclazocine; Ranidae; Rats; Receptors, Opioid; Sodium; Subcellular Fractions; Temperature | 1989 |
Serotonergic involvement in the antinociceptive action of and the development of tolerance to the kappa-opioid receptor agonist, U-50, 488H.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Cyclazocine; Drug Tolerance; Ethylketocyclazocine; Ketanserin; Male; Mice; Pindolol; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Serotonin; Serotonin Antagonists; Sympatholytics | 1989 |
Central and peripheral opioid modulation of gastric relaxation induced by feeding in dogs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Cyclazocine; Dogs; Dose-Response Relationship, Drug; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Morphine; Muscle Relaxation; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stomach; Vagotomy; Vagus Nerve | 1989 |
Presynaptic kappa-opioid receptors on noradrenergic nerve terminals couple to G proteins and interact with the alpha 2-adrenoceptors.
Topics: Animals; Biomechanical Phenomena; Cyclazocine; Ethylketocyclazocine; Ethylmaleimide; GTP-Binding Proteins; In Vitro Techniques; Nerve Endings; Norepinephrine; Pertussis Toxin; Rabbits; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, kappa; Signal Transduction; Synapses; Virulence Factors, Bordetella | 1989 |
Role of renal nerves in excretory responses to administration of kappa agonists in conscious spontaneously hypertensive rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cyclazocine; Diuresis; Ethylketocyclazocine; Hemodynamics; Hypertension; Kidney; Male; Pyrrolidines; Rats; Rats, Inbred SHR; Receptors, Opioid; Receptors, Opioid, kappa; Sympathetic Nervous System | 1989 |
Opioid receptor affinities of the blood-derived tetrapeptides hemorphin and cytochrophin.
Topics: Animals; Brain Chemistry; Cyclazocine; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Female; Guinea Pigs; Hemoglobins; In Vitro Techniques; Male; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1989 |
Pharmacological activities of optically pure enantiomers of the kappa opioid agonist, U50,488, and its cis diastereomer: evidence for three kappa receptor subtypes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Benzeneacetamides; Benzodiazepines; Benzomorphans; Binding, Competitive; Brain Chemistry; Cyclazocine; Discrimination, Psychological; Ethylketocyclazocine; Female; Guinea Pigs; Macaca mulatta; Male; Membranes; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Stereoisomerism | 1989 |
Kappa opiate receptor multiplicity: evidence for two U50,488-sensitive kappa 1 subtypes and a novel kappa 3 subtype.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Binding Sites; Cattle; Cerebellum; Cyclazocine; Edetic Acid; Ethylketocyclazocine; Guinea Pigs; In Vitro Techniques; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1989 |
Changes in multiple opioid receptors in regions of the brain in rats treated chronically with thyroxine.
Topics: Animals; Blood Pressure; Body Weight; Brain; Chromatography, High Pressure Liquid; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; Heart Rate; Hyperthyroidism; Male; Membranes; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Thyroxine | 1989 |
Mu-opioid component of the ethylketocyclazocine (EKC) discriminative stimulus in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cyclazocine; Discrimination, Psychological; Dose-Response Relationship, Drug; Ethylketocyclazocine; Fentanyl; Male; Morphine; Naloxone; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, mu | 1989 |
Pharmacological characterization of the binding of [3H]bremazocine in guinea-pig brain: evidence for multiplicity of the kappa-opioid receptors.
Topics: Animals; Benzomorphans; Brain; Cyclazocine; Ethylketocyclazocine; Guinea Pigs; In Vitro Techniques; Kinetics; Male; Membranes; Models, Biological; Morphinans; Muscle, Smooth; Peptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereoisomerism | 1989 |
Antagonism of kappa opioid mediated effects in the rat by cyclo(Leu-Gly).
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Cerebral Cortex; Cyclazocine; Diuresis; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Male; Neuropeptides; Peptides, Cyclic; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Spinal Cord | 1989 |
Differential cross-tolerance to opioid agonists in morphine-tolerant squirrel monkeys responding under a schedule of food presentation.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Conditioning, Operant; Cyclazocine; Dose-Response Relationship, Drug; Drug Tolerance; Ethylketocyclazocine; Food; Male; Morphine; Narcotics; Pentobarbital; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, mu; Reinforcement Schedule; Saimiri | 1989 |
Effects of nitrous oxide and halothane on mu and kappa opioid receptors in guinea-pig brain.
Topics: Analgesics, Opioid; Animals; Brain; Cyclazocine; Dihydromorphine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Guinea Pigs; Halothane; Levorphanol; Male; Nitrous Oxide; Oxygen; Radioligand Assay; Receptors, Opioid | 1989 |
Kappa-receptor mechanisms in synaptosomal Ca uptake.
Topics: Animals; Calcium; Calcium Radioisotopes; Cyclazocine; Dynorphins; Ethylketocyclazocine; In Vitro Techniques; Male; Morphine; Nalorphine; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Synaptosomes | 1989 |
Computer analysis of the effect of beta-endorphin and dynorphin and related compounds on opioid binding to mouse brain membrane.
Topics: Animals; beta-Endorphin; Binding, Competitive; Brain; Cyclazocine; Dihydromorphine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Mice; Models, Neurological; Receptors, Opioid | 1989 |
Discriminative stimulus effects of mu and kappa opioids in the pigeon: analysis of the effects of full and partial mu and kappa agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Columbidae; Cyclazocine; Discrimination Learning; Ethylketocyclazocine; Fentanyl; Morphinans; Naloxone; Narcotics; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1989 |
Failure of opioids to affect excitation and contraction in isolated ventricular heart muscle.
Topics: Acetylcholine; Action Potentials; Animals; Cyclazocine; Ethylketocyclazocine; Guinea Pigs; Humans; Morphine; Myocardial Contraction; Naloxone; Norepinephrine; Papillary Muscles; Rabbits; Synapses | 1989 |
Cardiovascular and respiratory effects of an opioid kappa agonist ethylketazocine and sigma agonist N-allylnormetazocine in acutely decerebrated dogs.
Topics: Animals; Blood Pressure; Cyclazocine; Decerebrate State; Dogs; Ethylketocyclazocine; Female; Heart Rate; Male; Phenazocine; Pulmonary Ventilation | 1989 |
Effects of mu, kappa and sigma opioids on fixed consecutive number responding in rats.
Topics: Animals; Buprenorphine; Conditioning, Operant; Cyclazocine; Dextroamphetamine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Male; Morphine; Phenazocine; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma | 1987 |
Effects of ethylketocyclazocine on behaviors in mice using multi-dimensional behavioral analyses.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Grooming; Male; Mice; Motor Activity; Naloxone; Receptors, Opioid; Receptors, Opioid, kappa; Time Factors | 1987 |
Opioid kappa-receptor agonists suppress sexual behaviors in male rough-skinned newts (Taricha granulosa).
Topics: Analgesics; Animals; Benzomorphans; Cyclazocine; Ethylketocyclazocine; Male; Morphinans; Morphine; Naloxone; Receptors, Opioid; Salamandridae; Sexual Behavior, Animal | 1987 |
Mu antagonist properties of kappa agonists in a model of rat urinary bladder motility in vivo.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzodiazepines; Cyclazocine; Ethylketocyclazocine; Female; Morphine; Morphine Derivatives; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Urinary Bladder | 1987 |
Differentiation between mu and kappa receptor-mediated effects in opioid drug discrimination: apparent pA2 analysis.
Topics: Alfentanil; Animals; Azocines; Codeine; Cyclazocine; Discrimination Learning; Dose-Response Relationship, Drug; Ethylketocyclazocine; Fentanyl; Levorphanol; Macaca mulatta; Male; Morphine; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1987 |
Effects of kappa agonists and dexoxadrol on the acquisition of conditional discriminations in monkeys.
Topics: Analgesics; Animals; Benzomorphans; Conditioning, Psychological; Cyclazocine; Dioxolanes; Dioxoles; Discrimination Learning; Dose-Response Relationship, Drug; Erythrocebus patas; Ethylketocyclazocine; Female; Macaca fascicularis; Male; Naltrexone; Piperidines; Receptors, Opioid; Receptors, Opioid, kappa | 1987 |
The mu-opioid receptor in the 7315c tumor cell.
Topics: Cell Membrane; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; Oligopeptides; Receptors, Opioid; Receptors, Opioid, mu; Tumor Cells, Cultured | 1987 |
Nalbuphine: an autoradiographic opioid receptor binding profile in the central nervous system of an agonist/antagonist analgesic.
Topics: Analgesia; Animals; Autoradiography; Cyclazocine; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Haplorhini; Male; Morphinans; Nalbuphine; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1988 |
Evaluation of the effects of opioid agonists and antagonists under a delayed matching-to-sample procedure in pigeons.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Columbidae; Cyclazocine; Discrimination Learning; Endorphins; Ethylketocyclazocine; Female; Methadone; Morphine; Naloxone; Phencyclidine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma | 1987 |
Varying expression of opioid receptors and GTP-binding proteins in human pheochromocytomas.
Topics: Adrenal Gland Neoplasms; beta-Endorphin; Cell Membrane; Cyclazocine; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; GTP-Binding Proteins; Humans; Pheochromocytoma; Receptors, Opioid | 1986 |
Comparison of the opioid activity of CAM and kappa agonists.
Topics: Animals; Cyclazocine; Diuresis; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Morphinans; Muscle Contraction; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1986 |
Roles of central and peripheral mu, delta and kappa opioid receptors in the mediation of gastric acid secretory effects in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Cyclazocine; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Gastric Acid; Male; Morphine; Naltrexone; Pyrrolidines; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1988 |
Binaltorphimine-related bivalent ligands and their kappa opioid receptor antagonist selectivity.
Topics: Animals; Chemical Phenomena; Chemistry; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Male; Mice; Models, Molecular; Morphine; Muscle, Smooth; Naltrexone; Receptors, Opioid; Receptors, Opioid, kappa; Structure-Activity Relationship | 1988 |
Regulation of feeding behaviour in monosodium glutamate (MSG) treated mice.
Topics: Animals; Animals, Newborn; Benzomorphans; Cyclazocine; Eating; Ethylketocyclazocine; Glutamates; Mice; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, kappa; Sodium Glutamate | 1988 |
Photoaffinity labeling of opiate receptors using intrinsically photoactive 3H-opiates.
Topics: Affinity Labels; Animals; Benzomorphans; Binding Sites; Cholic Acids; Cyclazocine; Ethylketocyclazocine; Etorphine; In Vitro Techniques; Light; Male; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid; Tritium | 1988 |
Relation of diltiazem binding sites to opioid receptor subtypes in the guinea-pig brain.
Topics: Animals; Binding, Competitive; Brain; Cyclazocine; Dihydromorphine; Diltiazem; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Naloxone; Radioligand Assay; Receptors, Opioid | 1987 |
Temperature dependence of the binding of mu, delta and kappa agonists to the opiate receptors in guinea-pig brain.
Topics: Animals; Brain; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Temperature | 1988 |
Evidence for a non-opioid sigma binding site in the guinea-pig myenteric plexus.
Topics: Animals; Binding, Competitive; Cell Membrane; Chlorpromazine; Cyclazocine; Ethylketocyclazocine; Guinea Pigs; Haloperidol; Imipramine; Male; Myenteric Plexus; Phenazocine; Propranolol; Receptors, Opioid; Receptors, sigma | 1988 |
[3H]U-69593 labels a subtype of kappa opiate receptor with characteristics different from that labeled by [3H]ethylketocyclazocine.
Topics: Animals; Benzeneacetamides; Binding, Competitive; Brain; Cell Membrane; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Male; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Sodium Chloride; Temperature; Tritium | 1988 |
U50,488: a kappa-selective agent with poor affinity for mu1 opiate binding sites.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cyclazocine; Ethylketocyclazocine; Guinea Pigs; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1988 |
Only one pharmacophore is required for the kappa opioid antagonist selectivity of norbinaltorphimine.
Topics: Animals; Chemical Phenomena; Chemistry; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Ileum; Male; Mice; Morphine; Naltrexone; Receptors, Opioid; Receptors, Opioid, kappa; Stereoisomerism; Structure-Activity Relationship; Vas Deferens | 1988 |
Role of opioid receptors in bombesin-induced grooming.
Topics: Animals; Benzodiazepines; Bombesin; Cyclazocine; Drug Tolerance; Ethylketocyclazocine; Grooming; Molecular Conformation; Naloxone; Narcotics; Receptors, Opioid | 1988 |
Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Male; Mice; Morphine; Naltrexone; Oligopeptides; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa | 1988 |
Antagonism of the analgesic effects of mu and kappa opioid agonists in the squirrel monkey.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Azocines; Benzomorphans; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Fentanyl; Male; Methadone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri | 1988 |
Autoradiography of [3H]U-69593 binding sites in rat brain: evidence for kappa opioid receptor subtypes.
Topics: Analgesics; Animals; Autoradiography; Benzeneacetamides; Benzomorphans; Binding Sites; Brain Chemistry; Cyclazocine; Ethylketocyclazocine; Male; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Temperature | 1988 |
Ketocyclazocine, a kappa-opioid receptor agonist, and control of intestinal myoelectric activity in dogs.
Topics: Animals; Cyclazocine; Dogs; Electromyography; Ethylketocyclazocine; Intestine, Small; Muscle, Smooth; Receptors, Opioid; Receptors, Opioid, kappa; Stomach | 1988 |
Estimation of opioid receptor agonist dissociation constants with beta-chlornaltrexamine, an irreversible ligand which also displays agonism.
Topics: Animals; Cyclazocine; Drug Interactions; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphinans; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1988 |
Opioid receptor subtype-specific cross-tolerance to the effects of morphine on schedule-controlled behavior in mice.
Topics: Animals; Conditioning, Operant; Cyclazocine; Drug Tolerance; Enkephalin, Methionine; Ethylketocyclazocine; Ketamine; Levorphanol; Male; Mice; Morphine; Receptors, Opioid; Reinforcement Schedule | 1988 |
[3H]U69,593 binding in guinea-pig brain: comparison with [3H]ethylketazocine binding at the kappa-opioid sites.
Topics: Benzeneacetamides; Brain; Cyclazocine; Ethylketocyclazocine; Kinetics; Pyrrolidines; Radioligand Assay; Receptors, Opioid | 1988 |
Opiate receptor subtypes in the nucleus tractus solitarii of the cat: the effect of vagal section.
Topics: Animals; Autoradiography; Cats; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Female; Male; Medulla Oblongata; Naloxone; Receptors, Opioid; Vagotomy | 1988 |
Effect of methimazole-induced hypothyroidism on multiple opioid receptors in rat brain regions.
Topics: Animals; Body Temperature; Body Weight; Brain Chemistry; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; Heart Rate; Hypothyroidism; Male; Methimazole; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Triiodothyronine | 1988 |
Further demonstration of kappa opioid binding sites in the brain: evidence for heterogeneity.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Binding Sites; Brain; Cyclazocine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Guinea Pigs; Levallorphan; Peptide Fragments; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Stereoisomerism | 1985 |
Electrophysiological effects of dynorphin peptides on hippocampal pyramidal cells in rat.
Topics: Animals; Cyclazocine; Dynorphins; Electrophysiology; Endorphins; Enkephalin, Leucine; Ethylketocyclazocine; gamma-Aminobutyric Acid; Hippocampus; Male; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid | 1985 |
Analeptic effect of opiate receptor agonists in rabbits.
Topics: Animals; Arousal; Brain; Central Nervous System Stimulants; Codeine; Cyclazocine; Dose-Response Relationship, Drug; Enkephalin, Methionine; Ethylketocyclazocine; Etorphine; Male; Meperidine; Methadone; Morphine; Naltrexone; Narcotics; Phenazocine; Rabbits; Receptors, Opioid; Reflex | 1985 |
Displacement of 3H-EKC binding by opioids in rat kidney: a correlate to diuretic activity.
Topics: Analgesics, Opioid; Animals; Cyclazocine; Diuretics; Dose-Response Relationship, Drug; Ethylketocyclazocine; Kidney; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Tritium | 1985 |
Inhibition of Ca++-ATPase of rat erythrocyte membranes by k-opioid agonists.
Topics: Animals; beta-Endorphin; Calcium-Transporting ATPases; Cyclazocine; Dynorphins; Endorphins; Erythrocyte Membrane; Ethylketocyclazocine; Levorphanol; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1985 |
Generalization tests with intraventricularly applied pro-enkephalin B-derived peptides in rats trained to discriminate the opioid kappa receptor agonist ethylketocyclazocine.
Topics: Animals; beta-Endorphin; Cyclazocine; Discrimination Learning; Dynorphins; Endorphins; Enkephalins; Ethylketocyclazocine; Generalization, Stimulus; Injections, Intraventricular; Male; Protein Precursors; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1985 |
Effects of opioid agonists and antagonists on oxytocin and vasopressin release in vitro.
Topics: Animals; Arginine Vasopressin; Benzomorphans; beta-Endorphin; Cyclazocine; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Male; Naloxone; Oxytocin; Peptide Fragments; Pituitary Gland, Posterior; Rats; Rats, Inbred Strains | 1985 |
Effects of 2% sodium chloride imbibition on various opiate related hyperphagic conditions.
Topics: Animals; Cyclazocine; Deoxyglucose; Dynorphins; Ethylketocyclazocine; Feeding Behavior; Insulin; Male; Naloxone; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid; Sodium Chloride; Time Factors | 1985 |
An analysis of naltrexone and naloxone's possible agonistic actions in the dog.
Topics: Analgesics, Opioid; Animals; Cyclazocine; Dogs; Drug Synergism; Electroencephalography; Ethylketocyclazocine; Evoked Potentials; Female; Fentanyl; Morphine; Naloxone; Naltrexone; Reaction Time; Reflex; Reflex, Pupillary | 1985 |
Stereospecific opiate binding in living human polymorphonuclear leucocytes.
Topics: Analgesics, Opioid; Cyclazocine; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Granulocytes; Humans; Kinetics; Naloxone; Neutrophils; Receptors, Opioid | 1985 |
Intrinsic activity and effects of guanyl-5'-yl imidodiphosphate, Gpp(NH)p and sodium ion on the affinity of dynorphin 1-13, nalorphine and nalorphine-7,8-oxide to kappa-opioid receptor.
Topics: Animals; Binding, Competitive; Brain; Cyclazocine; Dynorphins; Ethylketocyclazocine; Guanosine Triphosphate; Guanylyl Imidodiphosphate; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Muscle Contraction; Muscle, Smooth; Nalorphine; Naloxone; Peptide Fragments; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Sodium; Synaptosomes; Vas Deferens | 1985 |
Dose-related effects of ethylketazocine on nociception, behaviour and autonomic responses in the horse.
Topics: Analgesics, Opioid; Animals; Autonomic Nervous System; Behavior, Animal; Body Temperature; Cyclazocine; Ethylketocyclazocine; Female; Horses; Male; Motor Activity; Pain; Pupil; Reaction Time | 1986 |
Differential effect of stimulation strength in mouse vas deferens on inhibition of neuroeffector transmission by receptor type selective opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Cyclazocine; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; In Vitro Techniques; Male; Mice; Morphine Derivatives; Muscle, Smooth; Neuromuscular Junction; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Synaptic Transmission | 1986 |
Characterization of opioid receptors modulating noradrenaline release in the hippocampus of the rabbit.
Topics: Animals; Benzomorphans; Clonidine; Cyclazocine; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; Hippocampus; Morphine; Norepinephrine; Rabbits; Receptors, Opioid | 1986 |
On the opioid receptor subtype inhibiting the evoked release of 3H-noradrenaline from guinea-pig atria in vitro.
Topics: Animals; Atropine; Benzomorphans; Binding, Competitive; Corticosterone; Cyclazocine; Desipramine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Guinea Pigs; Heart Atria; In Vitro Techniques; Morphine; Myocardium; Naloxone; Norepinephrine; Peptide Fragments; Phentolamine; Receptors, Opioid; Receptors, Opioid, kappa; Synapses | 1986 |
Presynaptic opioid receptors modulating acetylcholine release in the hippocampus of the rabbit.
Topics: Acetylcholine; Animals; Benzomorphans; Choline; Cyclazocine; Dose-Response Relationship, Drug; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Hippocampus; Naloxone; Peptide Fragments; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa; Synapses | 1986 |
Characterization of opioid receptors in the cat carotid body involved in chemosensory depression in vivo.
Topics: Animals; Carotid Body; Cats; Chemoreceptor Cells; Cyclazocine; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; Hypercapnia; Hypoxia; Peptide Fragments; Receptors, Opioid | 1986 |
Effects of dynorphin1-13 on opiate binding and dopamine and GABA uptake in stroked cat brain.
Topics: Animals; Brain; Brain Ischemia; Cats; Cyclazocine; Disease Models, Animal; Dopamine; Dynorphins; Ethylketocyclazocine; gamma-Aminobutyric Acid; Kinetics; Male; Peptide Fragments; Receptors, Opioid | 1986 |
Differential cross-tolerance among morphine, methadone, and ethylketocyclazocine--EEG and behavior.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Brain; Cyclazocine; Drug Tolerance; Electroencephalography; Ethylketocyclazocine; Female; Methadone; Morphine; Rats; Rats, Inbred Strains | 1986 |
Centrally-administered opioid selective agonists inhibit drinking in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Cyclazocine; Drinking Behavior; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Male; Morphine; Naloxone; Peptide Fragments; Pyrrolidines; Rats; Receptors, Opioid | 1986 |
Pharmacological effects of nalorphine and nalorphine-7,8-oxide (nalorphine-epoxide): interaction of the intrinsic activity, affinity and pharmacological responses.
Topics: Analgesics; Animals; Brain; Cyclazocine; Dihydromorphine; Dynorphins; Ethylketocyclazocine; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Nalorphine; Peptide Fragments; Rabbits; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid | 1986 |
[Peripheral analgesic actions of opioid peptides and morphine analogues].
Topics: Analgesics, Opioid; Animals; Cyclazocine; Dynorphins; Enkephalin, Methionine; Ethylketocyclazocine; Levallorphan; Lidocaine; Male; Mice; Morphine; Naloxone; Pain; Peptide Fragments | 1986 |
Bidirectional cross-tolerance between methadone (mu)- and ethylketocyclazocine (kappa)-tolerant rats.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Cyclazocine; Drug Tolerance; Electroencephalography; Ethylketocyclazocine; Female; Methadone; Rats; Rats, Inbred Strains | 1986 |
Blockade of alpha 2-adrenoceptors permits the operation of otherwise silent opioid kappa-receptors at the sympathetic axons of rabbit jejunal arteries.
Topics: Adrenergic alpha-Antagonists; Animals; Axons; Cyclazocine; Electric Stimulation; Ethylketocyclazocine; Female; In Vitro Techniques; Jejunum; Male; Muscle, Smooth, Vascular; Norepinephrine; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa; Sympathetic Nervous System | 1986 |
Binaltorphimine and nor-binaltorphimine, potent and selective kappa-opioid receptor antagonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Chemical Phenomena; Chemistry; Cyclazocine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Male; Mice; Morphine; Naloxone; Naltrexone; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa | 1987 |
Involvement of opioid receptors in phencyclidine-induced enhancement of brain histamine turnover in mice.
Topics: Analgesics, Opioid; Animals; Brain; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Haloperidol; Histamine; Histidine Decarboxylase; Ketamine; Male; Methylhistidines; Mice; Naloxone; Pargyline; Phenazocine; Phencyclidine; Receptors, Opioid | 1987 |
Opiates inhibit the discharges of fine afferent units from inflamed knee joint of the cat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Arthritis; Cats; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethylketocyclazocine; Morphine; Naloxone; Nociceptors; Pain; Peripheral Nerves; Pyrrolidines | 1987 |
Spinal kappa-opioid receptor-mediated antinociception is stimulus-specific.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzodiazepines; Benzomorphans; Cyclazocine; Drug Tolerance; Dynorphins; Ethylketocyclazocine; Injections, Spinal; Male; Morphine; Pyrrolidines; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Receptors, Opioid, kappa; Spinal Cord | 1987 |
Effects of selective and non-selective kappa-opioid receptor agonists on cutaneous C-fibre-evoked responses of rat dorsal horn neurones.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Action Potentials; Animals; Cyclazocine; Dose-Response Relationship, Drug; Dynorphins; Electric Stimulation; Ethylketocyclazocine; Injections, Spinal; Male; Naloxone; Nerve Fibers; Pain; Peptide Fragments; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Skin; Spinal Cord; Time Factors | 1987 |
Effects of ethylketazocine and morphine alone and in combination with naloxone on schedule-controlled behavior in pigeons.
Topics: Analgesics, Opioid; Animals; Columbidae; Conditioning, Operant; Cyclazocine; Dose-Response Relationship, Drug; Drug Interactions; Ethylketocyclazocine; Male; Morphine; Naloxone; Reinforcement Schedule | 1987 |
Inhibition of [3H][3-MeHis2]thyrotropin releasing hormone recognition sites in the rat brain by tifluadom, a kappa opiate receptor agonist.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analysis of Variance; Animals; Benzodiazepines; Brain; Cyclazocine; Dynorphins; Ethylketocyclazocine; Kinetics; Male; Peptide Fragments; Pyrrolidines; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Thyrotropin-Releasing Hormone; Thyrotropin-Releasing Hormone | 1987 |
Purification of a kappa-opioid receptor subtype from frog brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain Chemistry; Chromatography, Gel; Cyclazocine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Membranes; Molecular Weight; Naloxone; Peptide Fragments; Pyrrolidines; Rana esculenta; Receptors, Opioid; Receptors, Opioid, kappa; Solubility | 1987 |
Positive inotropic action of kappa opiate agonists, ethylketocyclazocine and dynorphin-A(1-13), in isolated rat atrium.
Topics: Animals; Cyclazocine; Dynorphins; Electric Stimulation; Ethylketocyclazocine; Heart; Heart Rate; In Vitro Techniques; Male; Myocardial Contraction; Peptide Fragments; Rats; Rats, Inbred Strains; Stimulation, Chemical | 1987 |
Opioid analgesia at peripheral sites: a target for opioids released during stress and inflammation?
Topics: Analgesics, Opioid; Animals; Carrageenan; Cyclazocine; Dextrorphan; Ethylketocyclazocine; Fentanyl; Hyperalgesia; Hyperesthesia; Inflammation; Levorphanol; Male; Peripheral Nerves; Rats; Receptors, Opioid | 1987 |
Heterogeneity of opioid receptor binding in brain slices.
Topics: Analgesics, Opioid; Animals; Brain; Corpus Striatum; Cyclazocine; Dihydromorphine; Ethylketocyclazocine; Etorphine; In Vitro Techniques; Male; Morphinans; Morphine Derivatives; Rats; Rats, Inbred Strains; Receptors, Opioid | 1987 |
Functional opioid receptor sites in human placentas.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Cyclazocine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethylketocyclazocine; Gonadotropin-Releasing Hormone; Humans; Kinetics; Placenta; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thyrotropin-Releasing Hormone | 1988 |
Extraordinary postmortem stability of kappa opioid receptors in guinea-pig brain.
Topics: Analgesics, Opioid; Animals; Brain Chemistry; Cyclazocine; Ethylketocyclazocine; Guinea Pigs; Male; Postmortem Changes; Receptors, Opioid; Receptors, Opioid, kappa | 1987 |
Inhibition of cardiac Na+, K+-ATPase activity by dynorphin-A and ethylketocyclazocine.
Topics: Adenosine Triphosphate; Animals; Cyclazocine; Dynorphins; Enzyme Activation; Ethylketocyclazocine; Male; Myocardium; Naloxone; Peptide Fragments; Potassium; Rats; Rats, Inbred Strains; Sodium; Sodium-Potassium-Exchanging ATPase | 1988 |
Opioid receptors of bovine posterior pituitary neurosecretosomes are exclusively kappa.
Topics: Analgesics, Opioid; Animals; Cattle; Cyclazocine; Cytoplasmic Granules; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Kinetics; Morphinans; Pituitary Gland, Posterior; Receptors, Opioid; Receptors, Opioid, kappa | 1986 |
Different effects of ethylketocyclazocine on phencyclidine- and N-allylnormetazocine-induced stereotyped behaviors in rats.
Topics: Analgesics, Opioid; Animals; Cyclazocine; Ethylketocyclazocine; Male; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Stereotyped Behavior | 1987 |
Peripheral antagonistic action of trimebutine and kappa opioid substances on acoustic stress-induced gastric motor inhibition in dogs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acoustic Stimulation; Analgesics; Analgesics, Opioid; Animals; Benzoates; Benzomorphans; Cyclazocine; Dogs; Ethylketocyclazocine; Gastrointestinal Motility; Injections, Intravenous; Injections, Intraventricular; Naloxone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Stress, Psychological; Trimebutine | 1988 |
Observational analysis of the effects of kappa opioid agonists an open field behaviour in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Benzodiazepines; Benzomorphans; Cyclazocine; Diuretics; Ethylketocyclazocine; Male; Motor Activity; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Time Factors | 1988 |
Nocturnal depletion of hypothalamic dynorphin in anorexic Walker-256 tumor-bearing rats.
Topics: Animals; Anorexia; Carcinoma 256, Walker; Circadian Rhythm; Cyclazocine; Dynorphins; Eating; Ethylketocyclazocine; Feeding and Eating Disorders; Hypothalamus; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1988 |
Effect of ethylketocyclazocine on acetylcholine release in guinea-pig brain slices.
Topics: Acetylcholine; Analgesics, Opioid; Animals; Brain; Cyclazocine; Ethylketocyclazocine; Guinea Pigs; In Vitro Techniques; Morphine; Naloxone | 1988 |
CNS blockade of acoustic stress-induced gastric motor inhibition by kappa-opiate agonists in dogs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acoustic Stimulation; Adrenocorticotropic Hormone; Analgesics; Animals; Cyclazocine; Dogs; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethylketocyclazocine; Gastrointestinal Motility; Hydrocortisone; Pyrrolidines; Stress, Physiological | 1988 |
Characterization of opioid binding sites in murine neuroblastoma.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Cell Line; Clone Cells; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Kinetics; Ligands; Mice; Neuroblastoma; Receptors, Opioid | 1988 |
Selective protection of benzomorphan binding sites against inactivation by N-ethylmaleimide. Evidence for kappa-opioid receptors in frog brain.
Topics: Animals; Benzomorphans; Binding Sites; Brain; Cyclazocine; Dynorphins; Ethylketocyclazocine; Ethylmaleimide; Morphinans; Peptide Fragments; Rana esculenta; Receptors, Opioid; Sodium Chloride | 1988 |
Opioid and nicotinic medullary hyperalgesic influences in the decerebrated rat.
Topics: Analgesics, Opioid; Animals; Cyclazocine; Cystine; Decerebrate State; Endorphins; Ethylketocyclazocine; Female; Hyperalgesia; Hyperesthesia; Lobeline; Medulla Oblongata; Nicotine; Piperidines; Rats; Rats, Inbred Strains | 1988 |
Investigations on dynorphin structurally-related opioid peptides. I. Impact on nociceptive transmission. II. Regulation of pituitary content.
Topics: Animals; Benzomorphans; Cyclazocine; Dynorphins; Estradiol; Ethylketocyclazocine; Female; Hypothalamo-Hypophyseal System; Male; Ovary; Pain; Pain Measurement; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1988 |
Peripheral and central antinociceptive actions of ethylketocyclazocine in the formalin test.
Topics: Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Cyclazocine; Ethylketocyclazocine; Formaldehyde; Injections, Intraventricular; Male; Naloxone; Pain; Rats | 1988 |
Characterization of kappa opioid receptors in the rabbit ear artery.
Topics: Animals; Benzeneacetamides; Benzomorphans; Cyclazocine; Dynorphins; Ethylketocyclazocine; In Vitro Techniques; Male; Mice; Muscle, Smooth, Vascular; Narcotic Antagonists; Peptide Fragments; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1988 |
Presynaptic alpha 2-adrenoceptor, opioid kappa-receptor and adenosine A1-receptor interactions on noradrenaline release in rabbit brain cortex.
Topics: Analgesics, Opioid; Animals; Cadmium; Cerebral Cortex; Clonidine; Cocaine; Cyclazocine; Drug Interactions; Electric Stimulation; Ethylketocyclazocine; Female; In Vitro Techniques; Male; Norepinephrine; Phenylisopropyladenosine; Rabbits; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Purinergic; Tetrodotoxin; Yohimbine | 1988 |
Only activated but not non-activated presynaptic alpha 2-autoreceptors interfere with neighbouring presynaptic receptor mechanisms.
Topics: Analgesics, Opioid; Animals; Cyclazocine; Electric Stimulation; Ethylketocyclazocine; Female; In Vitro Techniques; Male; Norepinephrine; Phenylisopropyladenosine; Receptors, Adrenergic, alpha; Synapses; Yohimbine | 1988 |
Characterization of human placental opioid receptors by 3H-ethylketocyclazocine and 3H-naloxone binding.
Topics: Analgesics, Opioid; Binding, Competitive; Cell Membrane; Cyclazocine; Ethylketocyclazocine; Female; Humans; Kinetics; Naloxone; Placenta; Pregnancy; Receptors, Opioid; Receptors, Opioid, kappa | 1988 |
Body temperature effects of opioids in rats: intracerebroventricular administration.
Topics: Animals; beta-Endorphin; Body Temperature; Cyclazocine; Dose-Response Relationship, Drug; Endorphins; Ethylketocyclazocine; Etorphine; Heroin; Injections, Intraventricular; Injections, Subcutaneous; Male; Morphine; Naloxone; Narcotics; Pentazocine; Phenazocine; Rats; Rats, Inbred Strains | 1986 |
Identification of multiple opiate receptors through neuroendocrine responses. I. Effects of agonists.
Topics: Animals; Corticosterone; Cyclazocine; Ethylketocyclazocine; Growth Hormone; Injections, Subcutaneous; Luteinizing Hormone; Male; Morphine; Phenazocine; Pituitary Hormones, Anterior; Prolactin; Rats; Rats, Inbred Strains; Receptors, Opioid | 1985 |
Identification of multiple opiate receptors through neuroendocrine responses. II. Antagonism of mu, kappa and sigma agonists by naloxone and WIN 44,441-3.
Topics: Animals; Azocines; Corticosterone; Cyclazocine; Drug Interactions; Ethylketocyclazocine; Growth Hormone; Luteinizing Hormone; Male; Morphine; Naloxone; Narcotic Antagonists; Phenazocine; Pituitary Hormones, Anterior; Prolactin; Rats; Rats, Inbred Strains; Receptors, Opioid | 1985 |
The influence of opiate agonists on day-night feeding rhythms in young and old mice.
Topics: Aging; Animals; Cyclazocine; Endorphins; Ethylketocyclazocine; Feeding Behavior; Male; Mice; Morphine; Naloxone; Periodicity; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1985 |
Differential ontogeny of multiple opioid receptors (mu, delta, and kappa).
Topics: Animals; Animals, Newborn; Brain; Computers; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium | 1985 |
TENA, a selective kappa opioid receptor antagonist.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Azocines; Benzomorphans; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Ileum; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1985 |
A kappa-selective opioidergic pathway is involved in the reversal of a behavioural effect of adrenalectomy.
Topics: Adrenalectomy; Animals; Benzomorphans; Cyclazocine; Enkephalins; Ethylketocyclazocine; Immobilization; Male; Memory; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1985 |
Opiate receptor binding profile in the rabbit cerebellum and brain membranes.
Topics: Animals; beta-Endorphin; Binding Sites; Binding, Competitive; Brain; Cerebellum; Cold Temperature; Cyclazocine; Dihydromorphine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; In Vitro Techniques; Male; Rabbits; Receptors, Opioid; Sodium; Tritium | 1985 |
Differentiating aspects of opioid receptor binding by [3H](-) (1R,5R,9R,2''S)-5,9-dimethyl-2-tetrahydrofurfuryl-2'-hydroxy-6,7- benzomorphan hydrochloride ([3H]Mr 2034), a drug preferentially acting on kappa-receptors.
Topics: Animals; Benzomorphans; Binding, Competitive; Cyclazocine; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; In Vitro Techniques; Kinetics; Male; Morphinans; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1985 |
Separation of kappa-opioid receptor subtype from frog brain.
Topics: Animals; Brain Chemistry; Centrifugation, Density Gradient; Chromatography, Gel; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; Rana esculenta; Receptors, Opioid; Receptors, Opioid, kappa | 1985 |
Differentiating opioids by their pupillary effects in the rat.
Topics: Animals; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Male; Methadone; Motor Activity; Naloxone; Narcotics; Nystagmus, Physiologic; Phenazocine; Pupil; Rats; Rats, Inbred Strains; Receptors, Opioid; Stereoisomerism | 1985 |
Binding characteristics of kappa opioids in rat brain. A comparison of in vitro binding paradigms.
Topics: Animals; Binding, Competitive; Brain; Cyclazocine; Diprenorphine; Ethylketocyclazocine; Kinetics; Male; Morphinans; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1985 |
Effects of ethylketocyclazocine on adrenergic transmission in the isolated perfused cat spleen.
Topics: Animals; Cats; Cyclazocine; Electric Stimulation; Ethylketocyclazocine; Female; In Vitro Techniques; Male; Norepinephrine; Perfusion; Receptors, Opioid; Receptors, Opioid, kappa; Spleen; Sympathetic Nervous System; Synaptic Transmission | 1985 |
Detection and characterization of four binding sites for opioids in the mouse brain.
Topics: Animals; Binding Sites; Brain Chemistry; Cyclazocine; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Models, Biological; Naloxone; Receptors, Opioid; Software; Tritium | 1985 |
(+)-[3H]SKF 10,047, (+)-[3H]ethylketocyclazocine, mu, kappa, delta and phencyclidine binding sites in guinea pig brain membranes.
Topics: Animals; Binding Sites; Brain Chemistry; Cyclazocine; Ethylketocyclazocine; Guinea Pigs; In Vitro Techniques; Kinetics; Male; Membranes; Narcotics; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, Phencyclidine; Receptors, sigma; Trypsin; Type C Phospholipases | 1985 |
Mu, but not kappa, opioid agonists induce contractions of the canine small intestine ex vivo.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Cyclazocine; Dimethylphenylpiperazinium Iodide; Dogs; Ethylketocyclazocine; Gastrointestinal Motility; In Vitro Techniques; Intestine, Small; Morphine; Nalorphine; Phenazocine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1985 |
Effects of guanyl nucleotides and ions on kappa opioid binding.
Topics: Animals; Brain; Cyclazocine; Ethylketocyclazocine; Guanine Nucleotides; Guanosine Triphosphate; In Vitro Techniques; Kinetics; Magnesium; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Sodium | 1985 |
Profile of activity of kappa receptor agonists in the rabbit vas deferens.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzodiazepines; Benzomorphans; Butorphanol; Cyclazocine; Ethylketocyclazocine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nalorphine; Naloxone; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1985 |
Opioid binding to rat and guinea-pig neural membranes in the presence of physiological cations at 37 degrees C.
Topics: Animals; Brain; Cations; Cyclazocine; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guanosine Triphosphate; Guinea Pigs; In Vitro Techniques; Male; Narcotics; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Temperature; Tritium | 1985 |
In vivo receptor binding of opioid drugs at the mu site.
Topics: Animals; Brain; Cyclazocine; Ethylketocyclazocine; Etorphine; Female; Guanosine Triphosphate; In Vitro Techniques; Narcotic Antagonists; Narcotics; Rats; Receptors, Opioid; Receptors, Opioid, mu; Sodium; Tritium | 1985 |
Plasma corticosterone changes in response to central or peripheral administration of kappa and sigma opiate agonists.
Topics: Animals; Brain; Corticosterone; Cyclazocine; Ethylketocyclazocine; Humans; Hypothalamo-Hypophyseal System; Male; Morphine; Naloxone; Naltrexone; Opioid-Related Disorders; Phenazocine; Pituitary-Adrenal System; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma | 1985 |
Behavioural effects in rats of unilateral and bilateral injections of opiate receptor agonists into the globus pallidus.
Topics: Animals; Cyclazocine; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Female; Globus Pallidus; Motor Activity; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1985 |
Evidence for a kappa-opioid receptor on pituitary astrocytes: an autoradiographic study.
Topics: Animals; Astrocytes; Autoradiography; Binding Sites; Binding, Competitive; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Etorphine; Pituitary Gland; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1985 |
Autoradiographic localization of kappa opiate receptors in CNS taste and feeding areas.
Topics: Animals; Autoradiography; Binding, Competitive; Brain; Corpus Striatum; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Feeding Behavior; Limbic System; Male; Morphine; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Taste | 1985 |
The kappa opioid receptor and food intake.
Topics: Animals; Benzodiazepines; Benzomorphans; Butorphanol; Cyclazocine; Diprenorphine; Eating; Ethylketocyclazocine; Haloperidol; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Stereoisomerism; Time Factors | 1985 |
Interaction of opiates with opioid binding sites in the bovine adrenal medulla: II. Interaction with kappa sites.
Topics: Adrenal Medulla; Animals; Benzomorphans; Binding Sites; Calcium; Cattle; Cyclazocine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Ethylketocyclazocine; Ethylmaleimide; Etorphine; Guinea Pigs; Kinetics; Lithium; Manganese; Narcotics; Oligopeptides; Phospholipases A; Potassium; Receptors, Opioid; Receptors, Opioid, kappa; Sodium; Stereoisomerism | 1985 |
Opioid activity of lefetamine.
Topics: Anesthetics, Local; Animals; Binding, Competitive; Brain; Cyclazocine; Enkephalin, Methionine; Ethylketocyclazocine; Lethal Dose 50; Male; Methadone; Mice; Morphine; Naloxone; Phenethylamines; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid | 1985 |
The pineal gland and opiate-induced feeding.
Topics: Animals; Butorphanol; Cyclazocine; Endorphins; Ethylketocyclazocine; Feeding Behavior; Male; Melatonin; Morphine; Naloxone; Pineal Gland; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1985 |
Effects of opiate antagonists and putative kappa agonists on unpunished and punished operant behavior in the rat.
Topics: Animals; Conditioning, Operant; Cyclazocine; Diprenorphine; Ethylketocyclazocine; Male; Naloxone; Narcotic Antagonists; Punishment; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1985 |
Impairment of ketocyclazocine antinociception in rats by perinatal lead exposure.
Topics: Animals; Animals, Newborn; Animals, Suckling; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Female; Lead; Lead Poisoning; Pain; Pregnancy; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Sensory Thresholds | 1985 |
Involvement of different opioid receptor subtypes in electric shock-induced analgesia and motor suppression in the rat.
Topics: Animals; Cyclazocine; Electroshock; Enkephalin, Methionine; Ethylketocyclazocine; Male; Motor Activity; Naloxone; Pain; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Opioid; Time Factors | 1985 |
Interactions of codeine-7,8-oxide (codeine-epoxide), as a new metabolite of codeine, with multiple opiate receptors.
Topics: Animals; Brain; Cell Membrane; Codeine; Cyclazocine; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guanosine Triphosphate; Male; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid; Sodium Chloride | 1985 |
Direct action of opiates on bromocriptine-inhibited prolactin release by human prolactinoma cells in primary culture.
Topics: Adenoma; Bromocriptine; Cells, Cultured; Cyclazocine; Dopamine; Drug Interactions; Ethylketocyclazocine; Female; Humans; Male; Narcotics; Pituitary Neoplasms; Prolactin; Receptors, Opioid | 1985 |
Comparison of abstinence syndromes following chronic administration of mu and kappa opioid agonists in the rat.
Topics: Animals; Cyclazocine; Dose-Response Relationship, Drug; Electroencephalography; Electromyography; Ethylketocyclazocine; Female; Morphine; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sleep, REM; Substance Withdrawal Syndrome | 1985 |
Opioid receptors in human placenta may be affected by methadone and propoxyphene treatment.
Topics: Cyclazocine; Dextropropoxyphene; Ethylketocyclazocine; Female; Humans; In Vitro Techniques; Methadone; Placenta; Pregnancy; Receptors, Opioid; Substance-Related Disorders | 1985 |
Effects of tifluadom on food consumption compared with chlordiazepoxide and kappa agonists in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzodiazepinones; Benzomorphans; Chlordiazepoxide; Convulsants; Cyclazocine; Drug Interactions; Eating; Ethylketocyclazocine; Flumazenil; Male; Naloxone; Pyrazoles; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1985 |
Effects of kappa opiate agonists on palatable food consumption in non-deprived rats, with and without food preloads.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Cyclazocine; Eating; Ethylketocyclazocine; Male; Morphine; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Satiety Response | 1985 |
A monoclonal antibody capable of modulating opioid binding to rat neural membranes.
Topics: Animals; Antibodies, Monoclonal; Cell Line; Cyclazocine; Dihydromorphine; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Flunitrazepam; Immunoglobulin M; Kinetics; Male; Mice; Mice, Inbred BALB C; Molecular Weight; Naloxone; Narcotics; Nerve Tissue; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Opioid | 1985 |
Voltage dependent changes in opiate inhibition of electrically-driven guinea pig ileum longitudinal muscle.
Topics: Animals; Cyclazocine; Electric Stimulation; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine Derivatives; Muscle, Smooth; Naloxone; Narcotics; Receptors, Opioid | 1985 |
A radiolabeled-ligand-binding technique for the characterization of opioid receptors in the intact mouse vas deferens.
Topics: Animals; Binding, Competitive; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; In Vitro Techniques; Kinetics; Male; Mice; Morphine; Naltrexone; Radioligand Assay; Receptors, Opioid; Vas Deferens | 1985 |
Classification of presynaptic opioid receptors in the rabbit ear artery by competitive antagonists.
Topics: Animals; Arteries; Benzomorphans; Binding, Competitive; Biological Assay; Cyclazocine; Ear; Enkephalin, Leucine; Ethylketocyclazocine; In Vitro Techniques; Naloxone; Rabbits; Receptors, Opioid; Synaptic Membranes | 1986 |
Agonist and antagonist actions of buprenorphine on three types of opioid receptor in isolated preparations.
Topics: Animals; Benzomorphans; Buprenorphine; Cyclazocine; Electric Stimulation; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Morphinans; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Rabbits; Rats; Rats, Inbred Strains; Receptors, Opioid; Species Specificity; Time Factors; Vas Deferens | 1986 |
Kappa-opiate binding to rat brain and guinea pig cerebellum: sensitivity towards ions and nucleotides.
Topics: Animals; Brain; Cerebellum; Cyclazocine; Electrolytes; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guanine Nucleotides; Guinea Pigs; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1986 |
Discriminative stimulus effects of the opioid antagonist diprenorphine in the squirrel monkey.
Topics: Animals; Cyclazocine; Diprenorphine; Discrimination Learning; Dose-Response Relationship, Drug; Ethylketocyclazocine; Generalization, Stimulus; Morphinans; Naloxone; Narcotic Antagonists; Phenazocine; Psychotropic Drugs; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Saimiri | 1986 |
Subclass specificity of anti-idiotypic anti-opiate receptor antibodies in rat brain, guinea pig cerebellum, & neuroblastoma x glioma (NG 108-15).
Topics: Animals; Antibodies, Anti-Idiotypic; Binding, Competitive; Cell Line; Cerebellum; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Morphine; Neurilemma; Neurons; Rats; Receptors, Opioid | 1986 |
Mu- and kappa-opiate agonists modulate ingestive behaviors in the slug, Limax maximus.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cyclazocine; Ethylketocyclazocine; Feeding Behavior; Mollusca; Morphine; Narcotic Antagonists; Narcotics; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Time Factors | 1986 |
Kappa opioid receptors in human lumbo-sacral spinal cord.
Topics: Adult; Aged; Binding Sites; Cyclazocine; Endorphins; Ethylketocyclazocine; Etorphine; Female; Humans; Lumbosacral Region; Male; Middle Aged; Narcotics; Osmolar Concentration; Receptors, Opioid; Spinal Cord | 1986 |
Convulsions may alter the specificity of kappa-opiate receptors.
Topics: Animals; Codeine; Cyclazocine; Drug Resistance; Electroshock; Ethylketocyclazocine; Male; Mice; Mice, Inbred C57BL; Morphine; Receptors, Opioid; Receptors, Opioid, kappa; Seizures | 1986 |
Conditioned suppression and opioid kappa receptor in mice.
Topics: Animals; Conditioning, Operant; Cyclazocine; Drug Tolerance; Ethylketocyclazocine; Male; Mice; Motor Activity; Naloxone; Narcotic Antagonists; Phencyclidine; Receptors, Opioid; Receptors, Opioid, kappa; Synaptic Membranes | 1986 |
Endogenous ligands for sigma opioid receptors in the brain ("sigmaphin"): evidence from binding assays.
Topics: Animals; Binding, Competitive; Brain; Chromatography, Gel; Cyclazocine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Kinetics; Male; Naloxone; Phenazocine; Phencyclidine; Radioligand Assay; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, Phencyclidine; Receptors, sigma | 1986 |
Interaction between [3H]ethylketocyclazocine and [3H]etorphine and opioid receptors in membranes from rat brain. A kinetic analysis.
Topics: Animals; Brain; Computers; Cyclazocine; Drug Interactions; Ethylketocyclazocine; Etorphine; Kinetics; Ligands; Membranes; Morphinans; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1986 |
Traumatic injury alters opiate receptor binding in rat spinal cord.
Topics: Animals; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Spinal Cord Injuries | 1986 |
Role of ADH in ethylketocyclazocine-induced diuresis: studies in the Brattleboro rat.
Topics: Animals; Cyclazocine; Diabetes Insipidus; Diuresis; Ethylketocyclazocine; Rats; Rats, Brattleboro; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Vasopressins | 1986 |
Phencyclidine-induced stereotyped behaviors after injection of ethylketocyclazocine, Mr 2266 and naltrexone in rats.
Topics: Animals; Benzomorphans; Cyclazocine; Drug Interactions; Ethylketocyclazocine; Male; Motor Skills; Naltrexone; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Opioid; Stereotyped Behavior | 1986 |
Opioid receptors of human placental villi modulate acetylcholine release.
Topics: Acetylcholine; Animals; Benzomorphans; Cyclazocine; Endorphins; Ethylketocyclazocine; Humans; Organ Culture Techniques; Placenta; Rats; Receptors, Opioid | 1986 |
Sodium regulation of agonist binding at opioid receptors. I. Effects of sodium replacement on binding at mu- and delta-type receptors in 7315c and NG108-15 cells and cell membranes.
Topics: Adenylyl Cyclase Inhibitors; Animals; Cell Line; Cell Membrane; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Etorphine; Glioma; Guinea Pigs; Monensin; Naloxone; Neuroblastoma; Pituitary Neoplasms; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sodium | 1986 |
Sodium regulation of agonist binding at opioid receptors. II. Effects of sodium replacement on opioid binding in guinea pig cortical membranes.
Topics: Animals; Cell Membrane; Cerebral Cortex; Cyclazocine; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Etorphine; Guinea Pigs; Male; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium | 1986 |
Opioid ligand binding sites in the spinal cord of the guinea-pig.
Topics: Animals; Binding, Competitive; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; In Vitro Techniques; Kinetics; Male; Membranes; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1986 |
Reversal by beta-funaltrexamine of the antinociceptive effect of opioid agonists in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Buprenorphine; Cyclazocine; Ethylketocyclazocine; Fentanyl; Male; Naltrexone; Pain; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1986 |
Synthesis and opioid antagonist potencies of naltrexamine bivalent ligands with conformationally restricted spacers.
Topics: Animals; Biological Assay; Chemical Phenomena; Chemistry; Cyclazocine; Endorphins; Ethylketocyclazocine; Guinea Pigs; Ileum; Molecular Conformation; Morphine; Muscle Contraction; Naltrexone; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship | 1986 |
Studies of kappa agonist.
Topics: Animals; Brain; Cyclazocine; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; Humans; Morphine; Naloxone; Receptors, Opioid; Receptors, Opioid, kappa | 1986 |
Prejunctional opioid receptors in the pulmonary artery of the rabbit.
Topics: Animals; Cyclazocine; Electric Stimulation; Ethylketocyclazocine; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Naloxone; Narcotics; Norepinephrine; Pulmonary Artery; Rabbits; Receptors, Opioid; Tetrodotoxin | 1986 |
Involvement of opioid receptors in hypo- and hyperthermic effects induced by phencyclidine in mice.
Topics: Animals; Benzomorphans; Body Temperature; Cyclazocine; Ethylketocyclazocine; Hyperthermia, Induced; Hypothermia, Induced; Male; Mice; Morphine; Naloxone; Narcotic Antagonists; Phenazocine; Phencyclidine; Receptors, Opioid | 1986 |
Receptor protection experiments confirm the identity of presynaptic alpha 2-autoreceptors.
Topics: Animals; Cerebral Cortex; Clonidine; Cyclazocine; Ethylketocyclazocine; Female; In Vitro Techniques; Male; Norepinephrine; Phenoxybenzamine; Prazosin; Rabbits; Receptors, Adrenergic, alpha; Synapses; Yohimbine | 1986 |
Kappa opioid receptor-mediated analgesia in the developing rat.
Topics: Age Factors; Animals; Brain; Cyclazocine; Drug Tolerance; Ethylketocyclazocine; Hot Temperature; Morphine; Pain; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1986 |
Reversible and irreversible binding of beta-funaltrexamine to mu, delta and kappa opioid receptors in guinea pig brain membranes.
Topics: Animals; Brain; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Ethylmaleimide; Guinea Pigs; Kinetics; Male; Membranes; Naloxone; Naltrexone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium Chloride | 1986 |
Food hoarding and ingestion in the deer mouse, Peromyscus maniculatus: selective responses to mu and kappa opiate agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cyclazocine; Endorphins; Ethylketocyclazocine; Feeding Behavior; Food Deprivation; Male; Morphine; Peromyscus; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1986 |
A dose-ratio comparison of mu and kappa agonists in formalin and thermal pain.
Topics: Analgesia; Animals; Benzomorphans; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Fentanyl; Formaldehyde; Hot Temperature; Male; Naloxone; Pain; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sufentanil | 1986 |
Mutual interaction between presynaptic alpha 2-adrenoceptors and opioid kappa-receptors at the noradrenergic axons of rabbit brain cortex.
Topics: Animals; Axons; Cerebral Cortex; Clonidine; Cyclazocine; Ethylketocyclazocine; Female; Male; Naloxone; Norepinephrine; Rabbits; Receptors, Adrenergic, alpha; Receptors, Opioid; Yohimbine | 1986 |
[Differences in opioid binding in the left and right visual cortex of the turtle].
Topics: Animals; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Functional Laterality; Receptors, Opioid; Turtles; Visual Cortex | 1986 |
Selective proliferation of brain kappa opiate receptors in spontaneously hypertensive rats.
Topics: Animals; Binding, Competitive; Brain; Cyclazocine; Enkephalin, Leucine; Ethylketocyclazocine; Kinetics; Male; Naltrexone; Oligopeptides; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY; Receptors, Opioid; Receptors, Opioid, kappa | 1986 |
Discriminative stimulus effects of N-allylnormetazocine in rats trained to discriminate a kappa from a sigma agonist.
Topics: Animals; Cyclazocine; Discrimination Learning; Ethylketocyclazocine; Male; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, sigma; Stereoisomerism | 1987 |
Evaluation of the supraspinal analgesic activity and abuse liability of ethylketocyclazocine.
Topics: Analgesics; Animals; Brain; Cyclazocine; Escape Reaction; Ethylketocyclazocine; Male; Medial Forebrain Bundle; Rats; Reaction Time; Receptors, Opioid; Receptors, Opioid, kappa; Reward; Self Stimulation; Substance-Related Disorders | 1987 |
Unidirectional interaction between thyrotropin releasing hormone and opiates at the level of their brain receptors.
Topics: Animals; Brain; Cyclazocine; Enkephalin, Leucine; Ethylketocyclazocine; Male; Naltrexone; Oligopeptides; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid; Thyrotropin-Releasing Hormone | 1987 |
Morphine- and ketocyclazocine-induced analgesia in the developing rat: differences due to type of noxious stimulus and body topography.
Topics: Age Factors; Analgesics; Animals; Animals, Suckling; Central Nervous System; Cyclazocine; Ethylketocyclazocine; Morphine; Naloxone; Pain; Pain Measurement; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1987 |
TRH-induced antinociception: interaction with the opioid systems?
Topics: Analgesia; Animals; Brain; Cyclazocine; Endorphins; Ethylketocyclazocine; Fentanyl; Male; Mice; Morphine; Naloxone; Receptors, Opioid; Thyrotropin-Releasing Hormone | 1987 |
Use of beta-funaltrexamine to determine mu opioid receptor involvement in the analgesic activity of various opioid ligands.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Biological Assay; Buprenorphine; Butorphanol; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Etorphine; Fentanyl; Methadone; Mice; Morphine; Muscle Contraction; Nalbuphine; Nalorphine; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, mu | 1987 |
Modulation of rat brain opioid receptors by cannabinoids.
Topics: Animals; Cannabinoids; Cyclazocine; Dihydromorphine; Dose-Response Relationship, Drug; Dronabinol; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Etorphine; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Spiperone | 1987 |
Nonequilibrium opioid antagonist activity of 6,14-dideoxynaltrexone derivatives.
Topics: Animals; Cyclazocine; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Mice; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Structure-Activity Relationship | 1987 |
(+)- and (-)-N-allylnormetazocine binding sites in mouse brain: in vitro and in vivo characterization and regional distribution.
Topics: Animals; Binding, Competitive; Brain; Cyclazocine; Ethylketocyclazocine; Haloperidol; In Vitro Techniques; Mice; Naloxone; Phenazocine; Phencyclidine; Receptors, Opioid; Receptors, sigma; Stereoisomerism | 1987 |
Opioid receptor binding in rat spinal cord.
Topics: Animals; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Ligands; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1987 |
The topography and dynamics of cholinergic transmission in the myenteric plexus-smooth muscle preparation of the guinea-pig ileum; the effect of ketocyclazocine, a kappa opiate ligand.
Topics: Acetylcholine; Animals; Cyclazocine; Electric Stimulation; Electromyography; Ethylketocyclazocine; Guinea Pigs; Ileum; Ligands; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Narcotics; Parasympathetic Nervous System; Synaptic Transmission | 1987 |
Opiate receptor subtypes in the rat hypothalamus and neurointermediate lobe.
Topics: Animals; Binding, Competitive; Cyclazocine; Ethylketocyclazocine; Etorphine; Female; Hypothalamus; Kinetics; Naloxone; Phencyclidine; Pituitary Gland; Rats; Rats, Inbred Strains; Receptors, Opioid; Temperature | 1987 |
The topography of cholinergic transmission in the mechanism of drug action at muscarinic synapses of the guinea-pig ileum.
Topics: Action Potentials; Animals; Axons; Cholinergic Fibers; Cyclazocine; Electric Stimulation; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Synaptic Transmission | 1987 |
Opiates and medial hypothalamic knife cuts cause hyperphagia through different mechanisms.
Topics: Animals; Brain Mapping; Butorphanol; Cyclazocine; Dietary Carbohydrates; Dietary Fats; Eating; Ethylketocyclazocine; Hypothalamus, Middle; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1985 |
Kappa agonist-induced diuresis: evidence for stereoselectivity, strain differences, independence of hydration variables and a result of decreased plasma vasopressin levels.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Butorphanol; Cyclazocine; Diuresis; Drinking; Ethylketocyclazocine; Female; Male; Nalorphine; Pyrrolidines; Rats; Rats, Inbred Strains; Rats, Zucker; Receptors, Opioid; Receptors, Opioid, kappa; Stereoisomerism; Vasopressins; Water Deprivation | 1987 |
Differences of binding characteristics of non-selective opiates towards mu and delta receptor types.
Topics: Animals; Binding, Competitive; Brain; Cell Membrane; Cerebellum; Cyclazocine; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethylketocyclazocine; Etorphine; Male; Oligopeptides; Rabbits; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1987 |
Characteristics of opioid receptors in guinea-pig cerebellum and human placenta.
Topics: Animals; Binding, Competitive; Cerebellum; Cyclazocine; Ethylketocyclazocine; Female; Guanylyl Imidodiphosphate; Guinea Pigs; Humans; In Vitro Techniques; Male; Naloxone; Placenta; Pregnancy; Receptors, Opioid; Receptors, Opioid, kappa; Sodium | 1986 |
Synthesis and evaluation of melphalan-containing N,N-dialkylenkephalin analogues as irreversible antagonists of the delta opioid receptor.
Topics: Alkylation; Animals; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Melphalan; Mice; Morphine; Muscle, Smooth; Receptors, Opioid; Receptors, Opioid, delta; Structure-Activity Relationship | 1987 |
Ethylketocyclazocine and bremazocine analgesia in neonatal rats.
Topics: Analgesia; Analgesics; Animals; Animals, Newborn; Benzomorphans; Cyclazocine; Ethylketocyclazocine; Female; Male; Morphinans; Naltrexone; Narcotic Antagonists; Rats | 1988 |
Ethylketocyclazocine and N-cyclopropylmethyl-norazidomorphine are antagonists of morphine-induced analgesia in frog spinal cord.
Topics: Analgesia; Animals; Cyclazocine; Ethylketocyclazocine; Morphinans; Morphine; Naloxone; Narcotic Antagonists; Rana esculenta; Reflex; Spinal Cord | 1988 |
Localization of kappa-opioid binding sites in the guinea pig cerebellum.
Topics: Animals; Autoradiography; Binding Sites; Cerebellum; Cyclazocine; Ethylketocyclazocine; Guinea Pigs; Kainic Acid; Male; Narcotics; Tissue Distribution | 1988 |
Dose related effects of the kappa agonist U-50, 488H on behaviour, nociception and autonomic response in the horse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Autonomic Nervous System; Body Temperature; Chemical Phenomena; Chemistry; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Female; Fentanyl; Heart Rate; Horses; Locomotion; Male; Nociceptors; Pupil; Pyrrolidines; Respiration | 1988 |
Effects of opioid agonist drugs on the in vitro release of 3H-GABA, 3H-dopamine and 3H-5HT from slices of rat globus pallidus.
Topics: Animals; Cyclazocine; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dopamine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Female; gamma-Aminobutyric Acid; Globus Pallidus; Potassium Chloride; Rats; Rats, Inbred Strains; Serotonin | 1987 |
Kappa opioids in rhesus monkeys. II. Analysis of the antagonistic actions of quadazocine and beta-funaltrexamine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Azocines; Benzomorphans; Cyclazocine; Diuresis; Endorphins; Ethylketocyclazocine; Female; Hot Temperature; Macaca mulatta; Male; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Reaction Time; Tail | 1987 |
Kappa opioids in rhesus monkeys. III. Dependence associated with chronic administration.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Cyclazocine; Drug Tolerance; Endorphins; Ethylketocyclazocine; Macaca mulatta; Morphinans; Morphine; Narcotic Antagonists; Pentobarbital; Pyrrolidines; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1987 |
Phenylpropanolamine decreases food intake in rats made hyperphagic by various stimuli.
Topics: Animals; Appetite Depressants; Cyclazocine; Deoxyglucose; Dextroamphetamine; Eating; Ethylketocyclazocine; Feeding and Eating Disorders; Food Deprivation; Hyperphagia; Insulin; Male; Motor Activity; Phenylpropanolamine; Rats; Rats, Inbred Strains | 1987 |
Effects of morphine, ethylketocyclazocine, U-50,488H and naloxone on the acquisition of a classically conditioned response in the rabbit.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Cerebellum; Conditioning, Classical; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Female; Male; Morphine; Naloxone; Pyrrolidines; Rabbits | 1987 |
Comparison of the discriminative stimulus properties of U50,488 and morphine in pigeons.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Columbidae; Cyclazocine; Dextroamphetamine; Discrimination Learning; Dose-Response Relationship, Drug; Ethylketocyclazocine; Female; Fentanyl; Methadone; Morphine; Naloxone; Phenazocine; Phencyclidine; Pyrrolidines; Time Factors | 1987 |
Possible mechanism involved in the inhibitory action of U-50, 488H, an opioid kappa agonist, on guinea pig hippocampal CA3 pyramidal neurons in vitro.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Cyclazocine; Ethylketocyclazocine; Glutamates; Guinea Pigs; Hippocampus; In Vitro Techniques; Male; Neurons; Procaine; Pyramidal Tracts; Pyrrolidines; Tetrodotoxin; Veratrine | 1987 |
Neurochemical actions of ethylketocyclazocine and ketocyclazocine in different regions of rat brain.
Topics: Animals; Brain; Cyclazocine; Dopamine; Ethylketocyclazocine; Male; Norepinephrine; Rats; Rats, Inbred Strains; Serotonin | 1987 |
Differential antagonism by naltrexone of the effects of opioids on a fixed-ratio discrimination in rats.
Topics: Animals; Conditioning, Operant; Cyclazocine; Discrimination Learning; Dose-Response Relationship, Drug; Ethylketocyclazocine; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pentazocine; Rats | 1988 |
Effects of neonatal spinal cord serotonin depletion on opiate-induced analgesia in tests of thermal and mechanical pain.
Topics: 5,7-Dihydroxytryptamine; Analgesia; Animals; Animals, Newborn; Cyclazocine; Desipramine; Dihydroxytryptamines; Ethylketocyclazocine; Hot Temperature; Morphine; Pain; Physical Stimulation; Rats; Serotonin; Spinal Cord | 1988 |
Evaluation of the direct actions of drugs with a serotonergic link in spinal analgesia on the release of [3H]serotonin from spinal cord synaptosomes.
Topics: Analgesia; Animals; Calcium; Cyclazocine; Ethylketocyclazocine; In Vitro Techniques; Ketamine; Male; Morphine; Potassium; Quipazine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Spinal Cord; Synaptosomes | 1986 |
Differential protracted effects of morphine and ethylketocyclazocine challenges on EEG and behavior in the rat.
Topics: Animals; Behavior, Animal; Cyclazocine; Electroencephalography; Electromyography; Ethylketocyclazocine; Female; Morphine; Rats; Rats, Inbred Strains | 1986 |
Effects of ethylketazocine and morphine on schedule-controlled behavior in pigeons and squirrel monkeys.
Topics: Animals; Columbidae; Conditioning, Operant; Cyclazocine; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Ethylketocyclazocine; Food; Male; Morphine; Naloxone; Saimiri; Time Factors | 1986 |
Effects of morphine, ethylketocyclazocine, and N-allylnormetazocine on classical conditioning of the rabbit nictitating membrane response.
Topics: Animals; Conditioning, Classical; Conditioning, Eyelid; Cyclazocine; Ethylketocyclazocine; Female; Light; Male; Morphine; Nictitating Membrane; Phenazocine; Rabbits; Sound | 1986 |
Opiate-induced turning in rats after injection into the ventral tegmental area.
Topics: Animals; Cyclazocine; Diprenorphine; Endorphins; Ethylketocyclazocine; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Stereotyped Behavior; Tegmentum Mesencephali | 1986 |
Uptake of opioid drugs by rat cerebrocortical brain slices.
Topics: Animals; Cell Membrane; Cerebral Cortex; Cyclazocine; Ethylketocyclazocine; Etorphine; Kinetics; Membrane Lipids; Morphinans; Morphine; Rats; Rats, Inbred Strains | 1986 |
On the mechanisms of kappa-opioid-induced diuresis.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenal Medulla; Animals; Benzodiazepines; Catecholamines; Corticosterone; Cyclazocine; Diuresis; Ethylketocyclazocine; Male; Naloxone; Narcotics; Pyrrolidines; Rats; Sympatholytics | 1986 |
Selective breeding for levorphanol-induced antinociception on the hot-plate assay: commonalities in mechanism of action with morphine, pentazocine, ethylketocyclazocine, U-50488H and clonidine in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Clonidine; Cyclazocine; Ethylketocyclazocine; Female; Levorphanol; Male; Mice; Morphine; Narcotics; Pain; Pentazocine; Pyrrolidines | 1987 |
Effects of kappa opiate agonists, cholecystokinin and bombesin on intake of diets varying in carbohydrate-to-fat ratio in rats.
Topics: Animals; Body Weight; Bombesin; Butorphanol; Cyclazocine; Dietary Carbohydrates; Dietary Fats; Eating; Energy Intake; Ethylketocyclazocine; Food Preferences; Male; Naloxone; Rats; Rats, Inbred Strains; Sincalide | 1987 |
Evaluation of the effects of opioid agonists and antagonists under a fixed-consecutive-number schedule in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Conditioning, Operant; Cyclazocine; Discrimination Learning; Ethylketocyclazocine; Male; Methadone; Morphine; Naloxone; Narcotics; Phenazocine; Pyrrolidines; Rats; Reinforcement Schedule | 1987 |
The effects of tifluadom and ketazocine on behaviour, dopamine turnover in the basal ganglia and local cerebral glucose utilization of rats.
Topics: Animals; Benzodiazepines; Brain; Corpus Striatum; Cyclazocine; Dopamine; Ethylketocyclazocine; Glucose; Male; Motor Activity; Nucleus Accumbens; Rats; Rats, Inbred Strains | 1986 |
Determination of ketocyclazocine in human plasma by gas chromatography-negative-ion chemical-ionization mass spectrometry.
Topics: Cyclazocine; Ethylketocyclazocine; Gas Chromatography-Mass Spectrometry; Humans; Indicators and Reagents; Injections, Intramuscular | 1986 |
Selected opioids and responding for intracranial reinforcement.
Topics: Animals; Cyclazocine; Ethylketocyclazocine; Hypothalamic Area, Lateral; Naloxone; Phenazocine; Rats; Reinforcement, Psychology; Self Stimulation; Stereoisomerism | 1985 |
Comparative effects of opiate agonists on proximal and distal colonic motility in dogs.
Topics: Animals; Colon; Cyclazocine; Dogs; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Fentanyl; Gastrointestinal Motility; Injections, Intravenous; Injections, Spinal; Narcotics; Time Factors | 1985 |
The occurrence of cross-tolerance between morphine and ethyl-ketocyclazocine using the tail-flick test: lack of effect of diazepam, phenobarbital, or amphetamine.
Topics: Amphetamine; Animals; Cyclazocine; Diazepam; Drug Interactions; Drug Tolerance; Ethylketocyclazocine; Male; Mice; Morphine; Naloxone; Phenobarbital; Time Factors | 1985 |
Behavioral effects of a novel kappa opioid analgesic, U-50488, in rats and rhesus monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Cyclazocine; Discrimination, Psychological; Diuresis; Ethylketocyclazocine; Humans; Macaca mulatta; Male; Morphine; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains; Self Administration; Species Specificity; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1985 |
Behavioral effects of selected opiates and phencyclidine in the nondependent and cyclazocine-dependent rhesus monkey.
Topics: Animals; Behavior, Animal; Cyclazocine; Dose-Response Relationship, Drug; Drug Tolerance; Ethylketocyclazocine; Food; Macaca mulatta; Male; Naloxone; Phenazocine; Phencyclidine; Stereoisomerism; Substance-Related Disorders | 1985 |
Food intake: opioid/purine interactions.
Topics: Animals; Butorphanol; Caffeine; Cyclazocine; Drug Interactions; Endorphins; Ethylketocyclazocine; Feeding Behavior; Male; Naloxone; Purines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1984 |
Effects of a kappa receptor agonist, ethylketocyclazocine, on water consumption in water-deprived and nondeprived rats in diurnal and nocturnal tests.
Topics: Animals; Benzomorphans; Circadian Rhythm; Cyclazocine; Drinking Behavior; Ethylketocyclazocine; Male; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Water Deprivation | 1984 |
Kappa opiate receptor agonists: effects on behavior and on brain function and structure in rhesus monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Benzomorphans; Brain; Computers; Cyclazocine; Dose-Response Relationship, Drug; Electroencephalography; Ethylketocyclazocine; Evoked Potentials; Macaca mulatta; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa | 1984 |
Opioid control of the ruminant stomach motility: functional importance of mu, kappa and delta receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Ethylketocyclazocine; Fentanyl; Gastrointestinal Motility; Morphine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sheep; Stomach | 1984 |
An in vivo pharmacological analysis of benzomorphan binding sites in rats.
Topics: Animals; Benzomorphans; Bombesin; Brain; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Grooming; Humans; Male; Morphinans; Morphine; Naloxone; Narcotics; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Stereoisomerism; Stereotyped Behavior | 1984 |
Differential tolerance and cross-tolerance to chronic treatment with mu and kappa opioid agonists in the rat.
Topics: Animals; Arousal; Behavior, Animal; Brain; Cyclazocine; Drug Tolerance; Electroencephalography; Ethylketocyclazocine; Evoked Potentials; Female; Morphine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sleep Stages | 1984 |
Kappa opioid agonists and antagonists: effects on drinking and urinary output.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Butorphanol; Clonidine; Cyclazocine; Drinking; Ethylketocyclazocine; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Urination; Vasopressins | 1984 |
Comparison of sigma- and kappa-opiate receptor ligands as excitatory amino acid antagonists.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Cats; Cyclazocine; Ethylketocyclazocine; Kainic Acid; Ketamine; Ligands; Microelectrodes; N-Methylaspartate; Neurons; Oxadiazoles; Phenazocine; Quisqualic Acid; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, sigma; Stereoisomerism | 1984 |
[3H]Ethylketocyclazocine binding to mouse brain membranes: evidence for a kappa opioid receptor type.
Topics: Animals; Brain; Cyclazocine; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; In Vitro Techniques; Ligands; Male; Mice; Mice, Inbred ICR; Receptors, Opioid; Receptors, Opioid, kappa; Tritium | 1984 |
Genotype-dependent behavioral sensitivity to mu vs. kappa opiate agonists. I. Acute and chronic effects on mouse locomotor activity.
Topics: Animals; Body Weight; Cyclazocine; Ethylketocyclazocine; Genotype; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Morphine; Motor Activity; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Species Specificity | 1984 |
Genotype-dependent behavioral sensitivity to mu vs. kappa opiate agonists. II. Antinociceptive tolerance and physical dependence.
Topics: Analgesics; Animals; Cyclazocine; Drug Tolerance; Ethylketocyclazocine; Genotype; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Morphine; Opioid-Related Disorders; Pain; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Species Specificity | 1984 |
Altered opiate receptor binding in synaptosomes: implication of phosphorylation.
Topics: Animals; Cyclazocine; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Phosphorylation; Receptors, Opioid; Synaptosomes | 1984 |
Comparative antagonism by naltrexone and naloxone of mu, kappa, and delta agonists.
Topics: Animals; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1984 |
Differential, postnatal ontogeny of opiate and benzodiazepine receptor subtypes in rat cerebral cortex: binding characteristics of tifluadom and brotizolam.
Topics: Animals; Azepines; Benzodiazepines; Cerebral Cortex; Cyclazocine; Ethylketocyclazocine; Hypnotics and Sedatives; In Vitro Techniques; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Opioid; Tritium | 1984 |
Differential inhibition by propranolol of feeding induced in rats by various stimuli.
Topics: Animals; Cyclazocine; Deoxyglucose; Dose-Response Relationship, Drug; Eating; Ethylketocyclazocine; Insulin; Male; Naloxone; Propranolol; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1984 |
Ethylketocyclazocine decreases noradrenaline release and blood pressure in the rabbit at a peripheral opioid receptor.
Topics: Animals; Blood Pressure; Cyclazocine; Decerebrate State; Electric Stimulation; Ethylketocyclazocine; Female; Heart Rate; Hemodynamics; Male; Naloxone; Norepinephrine; Rabbits; Receptors, Opioid | 1984 |
Lesions of the globus pallidus and striatum attenuate ketocyclazocine-induced feeding.
Topics: Animals; Brain Mapping; Corpus Striatum; Cyclazocine; Endorphins; Ethylketocyclazocine; Feeding Behavior; Globus Pallidus; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1984 |
Differential neuropharmacological effects of mu, kappa and sigma opioid agonists on cortical EEG power spectra in the rat. Stereospecificity and naloxone antagonism.
Topics: Animals; Cerebral Cortex; Cyclazocine; Electroencephalography; Ethylketocyclazocine; Female; Methadone; Molecular Conformation; Morphine; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma | 1984 |
Kappa-opiates and urination: pharmacological evidence for an endogenous role of the kappa-opiate receptor in fluid and electrolyte balance.
Topics: Animals; Azocines; Benzomorphans; Cyclazocine; Diuresis; Ethylketocyclazocine; Female; Injections, Intraperitoneal; Morphinans; Morphine; Naloxone; Potassium; Rats; Rats, Inbred Strains; Receptors, Opioid; Sodium; Water-Electrolyte Balance | 1984 |
Radioligands for probing opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Binding Sites; Brain; Cyclazocine; Diprenorphine; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naloxone; Pro-Opiomelanocortin; Protein Precursors; Pyrrolidines; Radioligand Assay; Rats; Receptors, Opioid; Vas Deferens | 1984 |
Characterization of prototypical opioid antagonists, agonist-antagonists, and agonists in the morphine-dependent rhesus monkey.
Topics: Animals; Buprenorphine; Cyclazocine; Ethylketocyclazocine; Humans; Macaca mulatta; Morphine Dependence; Naloxone; Narcotic Antagonists; Narcotics; Receptors, Opioid; Receptors, Opioid, mu; Substance Withdrawal Syndrome | 1984 |
Peripheral opioid receptors located on the rat saphenous nerve.
Topics: Animals; Cyclazocine; Ethylketocyclazocine; Lidocaine; Male; Morphine; Naloxone; Peripheral Nerves; Rats; Rats, Inbred Strains; Receptors, Opioid; Vasodilation | 1984 |
Effects of full and partial kappa agonists and mu agonists on urine output of normally hydrated rats.
Topics: Animals; Benzomorphans; Cyclazocine; Diuresis; Ethylketocyclazocine; Naltrexone; Narcotics; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1984 |
EEG and behavioral effects of ethylketocyclazocine, morphine and cyclazocine in rats: differential sensitivities towards naloxone.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Cyclazocine; Electroencephalography; Ethylketocyclazocine; Male; Morphine; Naloxone; Rats | 1980 |
Dynorphin interaction at the kappa-opiate site.
Topics: Animals; Cyclazocine; Dynorphins; Electric Stimulation; Endorphins; Ethylketocyclazocine; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Receptors, Opioid; Receptors, Opioid, kappa | 1981 |
Spinal analgesia: comparison of the mu agonist morphine and the kappa agonist ethylketazocine.
Topics: Analgesics, Opioid; Animals; Cyclazocine; Ethylketocyclazocine; Male; Morphine; Rats; Reaction Time; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1981 |
Kappa opiate binding sites in human placenta.
Topics: Analgesics, Opioid; Binding, Competitive; Cell Membrane; Cyclazocine; Ethylketocyclazocine; Etorphine; Female; Humans; Kinetics; Placenta; Potassium; Pregnancy; Receptors, Opioid; Receptors, Opioid, kappa; Sodium | 1981 |
Demonstration and distribution of an opiate binding site in rat brain with high affinity for ethylketocyclazocine and SKF 10,047.
Topics: Analgesics, Opioid; Animals; Brain; Cerebral Cortex; Corpus Striatum; Cyclazocine; Ethylketocyclazocine; Kinetics; Mesencephalon; Phenazocine; Rats; Receptors, Opioid; Thalamus; Tissue Distribution | 1981 |
Distinct high-affinity binding sites for benzomorphan drugs and enkephalin in a neuroblastoma--brain hybrid cell line.
Topics: Analgesics, Opioid; Animals; Benzomorphans; Binding Sites; Binding, Competitive; Brain; Cell Line; Cyclazocine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Hybrid Cells; Kinetics; Morphinans; Neuroblastoma; Phenazocine; Rats; Receptors, Opioid | 1981 |
Opiate receptor antagonism by L-prolyl-L-leucyl-glycinamide, MIF-I.
Topics: Animals; Cyclazocine; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; Female; Ileum; In Vitro Techniques; Male; Mice; Morphine; Motor Activity; MSH Release-Inhibiting Hormone; Muscle Contraction; Pain; Rats; Rats, Inbred Strains; Receptors, Opioid; Vas Deferens | 1980 |
Stereospecific effects of cocaine derivatives on 3H-dopamine uptake: correlations with behavioral effects.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Brain; Cocaine; Corpus Striatum; Cyclazocine; Dopamine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Locomotion; Male; Molecular Conformation; Occipital Lobe; Rats; Stereoisomerism; Stereotaxic Techniques | 1981 |
Multiple opiate receptors: emerging concepts.
Topics: Analgesics, Opioid; Animals; Behavior; Binding, Competitive; Brain; Cyclazocine; Ethylketocyclazocine; Kinetics; Phenazocine; Rats; Receptors, Opioid; Structure-Activity Relationship | 1981 |
Dynorphin is a specific endogenous ligand of the kappa opioid receptor.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Brain; Cyclazocine; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; In Vitro Techniques; Ligands; Morphine Derivatives; Myenteric Plexus; Naloxone; Peptide Fragments; Receptors, Opioid | 1982 |
Studies on the nature and mechanism of the diuretic activity of the opioid analgesic ethylketocyclazocine.
Topics: Analgesics, Opioid; Animals; Body Water; Bufo marinus; Cyclazocine; Diuretics; Dose-Response Relationship, Drug; Ethylketocyclazocine; Male; Naltrexone; Radioimmunoassay; Rats; Rats, Inbred Strains; Urinary Bladder; Vasopressins | 1982 |
Discriminative stimulus, antagonist, and rate-decreasing effects of cyclorphan: multiple modes of action.
Topics: Animals; Columbidae; Conditioning, Psychological; Cyclazocine; Discrimination Learning; Dose-Response Relationship, Drug; Ethylketocyclazocine; Morphinans; Morphine | 1982 |
High affinity [3H]ethylketazocine binding: evidence for specific kappa receptors.
Topics: Analgesics, Opioid; Animals; Cyclazocine; Enkephalins; Ethylketocyclazocine; Ethylmaleimide; Rats; Receptors, Opioid; Tritium | 1982 |
Kappa opioid properties of dynorphin and its peptide fragments on the guinea-pig Ileum.
Topics: Animals; Cyclazocine; Drug Interactions; Drug Tolerance; Dynorphins; Endorphins; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Naloxone; Peptide Fragments; Receptors, Opioid; Receptors, Opioid, kappa | 1982 |
Discrimination of three opiate receptor binding sites with the use of a computerized curve-fitting technique.
Topics: Animals; Binding, Competitive; Brain; Computers; Cyclazocine; Dihydromorphine; Diprenorphine; Dynorphins; Endorphins; Ethylketocyclazocine; In Vitro Techniques; Kinetics; Phenazocine; Rats; Receptors, Opioid | 1982 |
Analgesic activity of intraspinally administered dynorphin and ethylketocyclazocine.
Topics: Analgesics; Animals; Cyclazocine; Dynorphins; Endorphins; Ethylketocyclazocine; Injections; Male; Mice; Spinal Cord | 1982 |
Stereospecific inhibition of oxotremorine-induced antinociception by (+)-isomers of opioid antagonists: comparison with opioid receptor agonists.
Topics: Animals; Benzomorphans; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Male; Mice; Morphine; Narcotic Antagonists; Nociceptors; Oxotremorine; Receptors, Opioid; Stereoisomerism | 1982 |
On the criteria for classifying opiate agonists in rats.
Topics: Analgesics; Animals; Charcoal; Cyclazocine; Ethylketocyclazocine; Gastrointestinal Motility; Male; Morphine; Naloxone; Narcotics; Rats; Rats, Inbred Strains | 1982 |
Activation of K-opiate sites by dynorphin in the myenteric plexus.
Topics: Animals; Cyclazocine; Drug Tolerance; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, Leucine; Ethylketocyclazocine; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Narcotics; Receptors, Opioid; Receptors, Opioid, kappa | 1982 |
In vivo evidence for multiple opiate receptors mediating analgesia in the rat spinal cord.
Topics: Animals; Cyclazocine; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Injections, Spinal; Male; Naloxone; Pain; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord | 1982 |
Kappa opiate receptors localized by autoradiography to deep layers of cerebral cortex: relation to sedative effects.
Topics: Analgesics; Analgesics, Opioid; Animals; Autoradiography; Benzomorphans; Brain Stem; Cerebral Cortex; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Male; Morphine; Organ Specificity; Receptors, Opioid; Receptors, Opioid, kappa; Tritium | 1982 |
Potency of three opiate antagonists to reverse the inhibitory activity of dynorphin, enkephalins and opioid-like alkaloids on the guinea pig ileum.
Topics: Animals; Azocines; Benzomorphans; Cyclazocine; Dynorphins; Endorphins; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine Derivatives; Muscle, Smooth; Naloxone; Narcotic Antagonists | 1982 |
Tolerance and cross-tolerance studies with morphine and ethylketocyclazocine.
Topics: Animals; Cyclazocine; Drug Implants; Drug Tolerance; Ethylketocyclazocine; Male; Morphine; Rats; Rats, Inbred Strains; Reaction Time | 1982 |
Effects of ketazocine, ethylketazocine and phenazocine on schedule-controlled behavior: antagonism by naloxone.
Topics: Analgesics, Opioid; Animals; Columbidae; Conditioning, Psychological; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Male; Naloxone; Phenazocine | 1982 |
Differential modification of opiate receptor activity by arylsulfatase treatment.
Topics: Analgesia; Analgesics, Opioid; Animals; Arylsulfatases; beta-Endorphin; Cyclazocine; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Drug Antagonism; Endorphins; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; Hormones; Kinetics; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Receptors, Opioid; Sulfatases | 1983 |
Analgesic actions of mu- and kappa-opiate agonists in rats.
Topics: Analgesics, Opioid; Animals; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Hot Temperature; Male; Nociceptors; Pain; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1983 |
Effects of elevated calcium and calcium antagonists on 6,7-benzomorphan-induced analgesia.
Topics: Analgesia; Analgesics; Analgesics, Opioid; Animals; Benzomorphans; Calcium; Calcium Channel Blockers; Cyclazocine; Egtazic Acid; Ethylketocyclazocine; Gallopamil; Male; Mice; Morphinans; Pentazocine; Phenazocine | 1983 |
Is dynorphin a k ligand?
Topics: Animals; Brain; Cyclazocine; Dynorphins; Endorphins; Ethylketocyclazocine; Receptors, Opioid; Receptors, Opioid, kappa | 1983 |
Further study of kappa opioids on increased urination.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Cyclazocine; Diuresis; Ethylketocyclazocine; Male; Morphinans; Naloxone; Narcotic Antagonists; Narcotics; Piperidines; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Urination | 1983 |
Possible medullary kappa hyperalgesic mechanism. I. A new potential role for endogenous opioid peptides in pain perception.
Topics: Animals; Cyclazocine; Dogs; Dynorphins; Endorphins; Ethylketocyclazocine; Medulla Oblongata; Naloxone; Pain; Receptors, Opioid; Reflex | 1983 |
Medullary kappa hyperalgesic mechanisms II. The effects of ethylketazocine administered into the fourth cerebral ventricle of the conscious dog.
Topics: Analgesics, Opioid; Animals; Cerebral Ventricles; Cyclazocine; Dogs; Ethylketocyclazocine; Female; Injections; Medulla Oblongata; Pain; Receptors, Opioid; Reflex | 1983 |
Dynorphin inhibition of the neurotensin contractile activity on the myenteric plexus.
Topics: Animals; Atropine; Cyclazocine; Dose-Response Relationship, Drug; Drug Tolerance; Dynorphins; Endorphins; Ethylketocyclazocine; Guinea Pigs; Ileum; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naloxone; Nerve Tissue Proteins; Neurotensin; Peptide Fragments; Receptors, Opioid; Tetrodotoxin | 1984 |
Kappa binding sites in guinea-pig brain membranes: evidence for a dynorphin-resistant subtype.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Brain; Cell Membrane; Cyclazocine; Ethylketocyclazocine; Guinea Pigs; Male; Phencyclidine; Receptors, Opioid; Receptors, Opioid, kappa | 1983 |
Comparative pharmacological properties and autoradiographic distribution of [3H]ethylketocyclazocine binding sites in rat and guinea pig brain.
Topics: Analgesics, Opioid; Animals; Autoradiography; Binding Sites; Binding, Competitive; Brain; Cyclazocine; Ethylketocyclazocine; Guinea Pigs; Narcotics; Rats; Species Specificity; Tissue Distribution; Tritium | 1983 |
Ontogeny of benzomorphan-selective (kappa) sites: a computerized analysis.
Topics: Aging; Analgesics, Opioid; Animals; Brain; Cyclazocine; Ethylketocyclazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1983 |
Placental kappa binding site : interaction with dynorphin and its possible implication in hCG secretion.
Topics: Analgesics, Opioid; Chorionic Gonadotropin; Cyclazocine; Dynorphins; Endorphins; Ethylketocyclazocine; Female; Humans; Peptide Fragments; Placenta; Pregnancy; Receptors, Opioid; Receptors, Opioid, kappa | 1983 |
Genetic differences in opioids binding sites and in antinociceptive activities of morphine and ethylketocyclazocine.
Topics: Analgesia; Analgesics, Opioid; Animals; Brain; Cyclazocine; Ethylketocyclazocine; Mice; Morphine; Nociceptors; Receptors, Opioid | 1983 |
Comparison of analgesic potencies of mu, delta and kappa agonists locally applied to various CNS regions relevant to analgesia in rats.
Topics: Analgesics, Opioid; Animals; Brain Stem; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Male; Morphine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1983 |
The effect of two different buffers on the high affinity 3H-ethylketocyclazocine and 3H-SKF10047 binding to guinea pig brain membranes.
Topics: Analgesics, Opioid; Animals; Brain; Cyclazocine; Ethylketocyclazocine; Guinea Pigs; HEPES; In Vitro Techniques; Morphine; Naloxone; Phenazocine; Piperazines; Receptors, Opioid; Tritium; Tromethamine | 1984 |
Resolution in the receptor binding of putative mu and kappa opiates.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Brain; Cell Membrane; Columbidae; Cyclazocine; Ethylketocyclazocine; Etorphine; Kinetics; Male; Morphinans; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Species Specificity | 1984 |
In vivo evidence for benzomorphan-selective receptors in rats.
Topics: Analgesics, Opioid; Animals; Benzomorphans; Bombesin; Buprenorphine; Cyclazocine; Dose-Response Relationship, Drug; Drug Tolerance; Ethylketocyclazocine; Male; Morphinans; Morphine; Naloxone; Phenazocine; Pruritus; Rats; Rats, Inbred Strains; Receptors, Opioid | 1984 |
Dynorphin A: inhibitory effect on other opiate ligand bindings in the mouse brain.
Topics: Animals; Brain; Cyclazocine; Dynorphins; Endorphins; Ethylketocyclazocine; In Vitro Techniques; Ligands; Male; Mice; Mice, Inbred ICR; Naloxone; Narcotics; Peptide Fragments; Receptors, Opioid; Sodium Chloride | 1984 |
Feeding systems in Chinese hamsters.
Topics: Animals; Brain; Calcitonin; Circadian Rhythm; Cricetinae; Cyclazocine; Diabetes Mellitus; Dynorphins; Eating; Endorphins; Ethylketocyclazocine; Feeding Behavior; Haloperidol; Mesocricetus; Naloxone; Peptide Fragments; Phenazocine; Sincalide; Starvation | 1984 |
Cardiac slowing induced by peripheral kappa-opiate receptor stimulation in rats.
Topics: Adrenergic beta-Antagonists; Animals; Benzomorphans; Cyclazocine; Electrocardiography; Ethylketocyclazocine; Heart Rate; Hemodynamics; Injections, Intravenous; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Time Factors; Vagotomy | 1984 |
Opioid receptor agonists in the rabbit colon: comparison of in vivo and in vitro studies.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Colon; Cyclazocine; Dynorphins; Electric Conductivity; Enkephalins; Ethylketocyclazocine; Fentanyl; Male; Morphine; Naloxone; Narcotics; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1984 |
Dynorphin-(1-13) restores the potency of morphine on the tolerant guinea pig ileum.
Topics: Animals; beta-Endorphin; Cyclazocine; Drug Interactions; Drug Tolerance; Dynorphins; Endorphins; Enkephalin, Leucine; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Peptide Fragments | 1984 |
Nitrous oxide generalizes to a discriminative stimulus produced by ethylketocyclazocine but not morphine.
Topics: Analgesics, Opioid; Animals; Cyclazocine; Ethylketocyclazocine; Generalization, Stimulus; Male; Morphine; Nitrous Oxide; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1984 |
The effect of ovariectomy, estradiol and progesterone on opioid modulation of feeding.
Topics: Animals; Appetite Regulation; Brain; Castration; Cyclazocine; Dynorphins; Eating; Estradiol; Ethylketocyclazocine; Female; Naloxone; Progesterone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1984 |
Affinities of some common opioid analgesics towards four binding sites in mouse brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Binding Sites; Brain; Codeine; Cyclazocine; Dextropropoxyphene; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Methionine; Ethylketocyclazocine; In Vitro Techniques; Membranes; Methadone; Mice; Models, Biological; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1984 |
Antagonism of the discriminative effects of ethylketazocine, cyclazocine, and nalorphine in macaques.
Topics: Analgesics, Opioid; Animals; Cyclazocine; Discrimination, Psychological; Ethylketocyclazocine; Macaca mulatta; Macaca nemestrina; Male; Nalorphine; Naltrexone; Narcotic Antagonists | 1984 |
[Dynorphin: analgesic effect via kappa receptors in the spinal cord of rats].
Topics: Analgesics; Animals; Cyclazocine; Dynorphins; Ethylketocyclazocine; Female; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Spinal Cord | 1984 |
Characteristics of 3H-tifluadom binding in guinea-pig brain membranes.
Topics: Animals; Benzodiazepines; Benzomorphans; Binding Sites; Brain; Cyclazocine; Dihydromorphine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; In Vitro Techniques; Male; Morphine; Receptors, Opioid | 1984 |
Binding of [3H]clonidine to membranes from cow neurohypophysis and cerebral cortex of the rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Cattle; Cerebral Cortex; Clonidine; Cyclazocine; Enkephalin, Leucine; Ethylketocyclazocine; In Vitro Techniques; Kinetics; Male; Membranes; Morphine; Naloxone; Narcotics; Pituitary Gland, Posterior; Rats | 1984 |
[Dynorphin: analgesic effect via kappa receptors in spinal cord of the spinal cords of rats].
Topics: Analgesics; Animals; Cyclazocine; Dynorphins; Ethylketocyclazocine; Female; Morphine; Naloxone; Pain; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Sensory Thresholds; Spinal Cord | 1984 |
Intrathecal opioids block a spinal action of substance P in mice: functional importance of both mu- and delta-receptors.
Topics: Animals; Cyclazocine; Enkephalins; Ethylketocyclazocine; Injections, Spinal; Male; Mice; Morphine; Narcotics; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord; Substance P; Synaptic Transmission | 1982 |
Specific, high affinity [3H]ethylketocyclazocine binding in rat central nervous system: lack of evidence for kappa receptors.
Topics: Animals; Binding, Competitive; Brain; Central Nervous System; Cyclazocine; Ethylketocyclazocine; In Vitro Techniques; Male; Rats; Receptors, Opioid; Salts; Spinal Cord | 1980 |
Multiple opiate receptors: [3H]ethylketocyclazocine receptor binding and ketocyclazocine analgesia.
Topics: Analgesics; Animals; Brain; Cyclazocine; Dihydromorphine; Dose-Response Relationship, Drug; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Mice; Morphine; Motor Activity; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1980 |
Bremazocine: a potent, long-acting opiate kappa-agonist.
Topics: Analgesia; Animals; Benzomorphans; Brain; Cyclazocine; Electric Stimulation; Ethylketocyclazocine; Guinea Pigs; Ileum; Macaca mulatta; Male; Mice; Morphinans; Morphine; Naloxone; Pentazocine; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Vas Deferens | 1980 |
Possible role of distinct morphine and enkephalin receptors in mediating actins of benzomorphan drugs (putative kappa and sigma agonists).
Topics: Animals; Benzomorphans; Brain; Cyclazocine; Diprenorphine; Endorphins; Enkephalins; Ethylketocyclazocine; Guanosine Triphosphate; Morphinans; Morphine; Naloxone; Neuroblastoma; Rats; Receptors, Opioid; Sodium; Synaptic Membranes | 1980 |
Discriminative stimulus effects of prototype opiate receptor agonists in monkeys.
Topics: Animals; Apomorphine; Cyclazocine; Ethylketocyclazocine; Female; Generalization, Stimulus; Haloperidol; Male; Models, Biological; Morphine; Naltrexone; Phenazocine; Prejudice; Receptors, Opioid; Saimiri | 1980 |
Endogenous peptide(s) inhibiting [3H]cocaine binding in mouse brain.
Topics: Animals; Binding Sites; Cell Membrane; Cerebral Cortex; Cocaine; Cyclazocine; Dihydromorphine; Dioxanes; Ethylketocyclazocine; Mice; Molecular Weight; Naloxone; Peptides; Receptors, Opioid; Spiperone | 1980 |
Involvement of mu-receptors in the opioid-induced generation of bursting discharges in hippocampal pyramidal cells.
Topics: Animals; Benzomorphans; Culture Techniques; Cyclazocine; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dose-Response Relationship, Drug; Electrophysiology; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Hippocampus; Membrane Potentials; Morphinans; Rats; Receptors, Opioid; Receptors, Opioid, mu | 1981 |
Characterization of the kappa-subtype of the opiate receptor in the guinea-pig brain.
Topics: Animals; Benzomorphans; Binding Sites; Binding, Competitive; Brain; Cyclazocine; Dihydromorphine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Naloxone; Naltrexone; Narcotics; Phenoxybenzamine; Receptors, Opioid | 1981 |
Strain differences in opiate receptors in mouse brain.
Topics: Animals; Brain; Cyclazocine; Dihydromorphine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Naloxone; Receptors, Opioid; Species Specificity | 1981 |
Evidence that dynorphin-(1-13) acts as an agonist on opioid kappa-receptors.
Topics: Animals; Cyclazocine; Dynorphins; Electric Stimulation; Endorphins; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Muscle, Smooth; Naloxone; Peptide Fragments; Rabbits; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Vas Deferens | 1982 |
D-Ala2,D-Leu5-enkephalin generalizes to a discriminative stimulus produced by fentanyl but not ethylketocyclazocine.
Topics: Animals; Cyclazocine; Discrimination, Psychological; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Fentanyl; Generalization, Stimulus; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1982 |
Benzomorphan binding sites in rat lumbo-sacral spinal cord.
Topics: Animals; Benzomorphans; Binding Sites; Cyclazocine; Ethylketocyclazocine; Etorphine; In Vitro Techniques; Kinetics; Lumbosacral Region; Male; Morphinans; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord | 1982 |
Interactions between narcotic agonists, partial agonists andd antagonists evaluated by punished an unpunished behavior in the rat.
Topics: Animals; Conditioning, Psychological; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Phenazocine; Punishment; Rats; Rats, Inbred Strains; Receptors, Opioid | 1982 |
The binding of kappa- and sigma-opiates in rat brain.
Topics: Animals; Binding Sites; Brain; Culture Techniques; Cyclazocine; Dihydromorphine; Enkephalins; Ethylketocyclazocine; Ligands; Male; Naloxone; Narcotics; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Tritium | 1982 |
Evidence that the discriminative stimulus properties of fentanyl and ethylketocyclazocine are mediated by an interaction with different opiate receptors.
Topics: Animals; Benzomorphans; Cyclazocine; Discrimination Learning; Discrimination, Psychological; Ethylketocyclazocine; Fentanyl; Male; Rats; Rats, Inbred Strains; Receptors, Opioid | 1982 |
The choice of opiate receptor subtype by neo-endorphins.
Topics: Animals; Benzomorphans; beta-Endorphin; Cyclazocine; Drug Interactions; Endorphins; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Naloxone; Protein Precursors; Rabbits; Receptors, Opioid | 1982 |
[Met5]enkephalin-Arg-Phe ACTS on vascular opiate receptors.
Topics: Animals; Cyclazocine; Electric Stimulation; Endorphins; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Rabbits; Receptors, Opioid | 1982 |
Differential effect of humoral endorphin on the binding of opiate agonists and antagonists.
Topics: Animals; Binding Sites; Binding, Competitive; Cyclazocine; Endorphins; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Quinuclidinyl Benzilate; Radioligand Assay; Rats; Receptors, Opioid; Sodium | 1982 |
Mu and kappa opioid agonists elevate brain stimulation threshold for escape by inhibiting aversion.
Topics: Animals; Avoidance Learning; Brain Stem; Cyclazocine; Electric Stimulation; Escape Reaction; Ethylketocyclazocine; Hypothalamic Area, Lateral; Male; Morphine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Self Stimulation | 1982 |
Opiate and opioid peptide binding in rat goldfish: further evidence for opiate receptor heterogeneity.
Topics: Animals; Brain; Cyclazocine; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Goldfish; Male; Naloxone; Narcotics; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma | 1982 |
Opiate receptor-mediated inhibition of catecholamine release in primary cultures of bovine adrenal chromaffin cells.
Topics: Acetylcholine; Adrenal Medulla; Animals; beta-Endorphin; Catecholamines; Cattle; Cells, Cultured; Chromaffin Granules; Chromaffin System; Cyclazocine; Dihydromorphine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Phenazocine; Receptors, Opioid | 1982 |
Discriminative stimulus properties of narcotic and non-narcotic drugs in rats trained to discriminate opiate kappa-receptor agonists.
Topics: Animals; Benzomorphans; Cyclazocine; Discrimination Learning; Dose-Response Relationship, Drug; Ethylketocyclazocine; Generalization, Stimulus; Male; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1982 |
A kappa opioid effect: increased urination in the rat.
Topics: Animals; Benzomorphans; Clonidine; Cyclazocine; Diuretics; Ethylketocyclazocine; Male; Narcotic Antagonists; Narcotics; Phencyclidine; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1983 |
A comparison of the receptor constants of morphine and ethylketocyclazocine for analgesia and inhibition of gastrointestinal transit in the rat.
Topics: Analgesia; Animals; Buprenorphine; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Gastrointestinal Motility; Male; Morphine; Rats; Rats, Inbred Strains; Receptors, Opioid | 1982 |
The epileptogenic spectrum of opiate agonists.
Topics: Animals; Anticonvulsants; beta-Endorphin; Cyclazocine; Electroencephalography; Endorphins; Enkephalin, Leucine; Epilepsy; Ethylketocyclazocine; Injections, Intraventricular; Male; Naloxone; Narcotics; Phenazocine; Rats; Rats, Inbred Strains | 1982 |
Improved assays for the assessment of kappa- and delta-properties of opioid ligands.
Topics: Animals; Cyclazocine; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Vas Deferens | 1982 |
Relative involvement of receptor subtypes in opioid-induced inhibition of gastrointestinal transit in mice.
Topics: Animals; Charcoal; Cyclazocine; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Female; Gastrointestinal Motility; Male; Mice; Morphine; Nalorphine; Naltrexone; Receptors, Opioid | 1983 |
An investigation of the role of kappa opiate receptor agonists in the initiation of feeding.
Topics: Animals; Circadian Rhythm; Cyclazocine; Eating; Ethylketocyclazocine; Male; Morphine; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Starvation; Time Factors | 1982 |
Evidence for multiple "Kappa" binding sites by use of opioid peptides in the guinea-pig lumbo-sacral spinal cord.
Topics: Animals; Binding Sites; Cyclazocine; Dihydromorphine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Guinea Pigs; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, kappa; Spinal Cord | 1982 |
Concerning the specificity of the hypothalamic opiate receptor responsible for food intake in the rat.
Topics: Animals; Body Temperature Regulation; Codeine; Cyclazocine; Dextrorphan; Eating; Ethylketocyclazocine; Levorphanol; Male; Morphine; Naloxone; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Ventromedial Hypothalamic Nucleus | 1982 |
Effects of opiate antagonists and putative mu- and kappa-agonists on milk intake in rat and squirrel monkey.
Topics: Animals; Buprenorphine; Cyclazocine; Diazepam; Diprenorphine; Drinking; Ethylketocyclazocine; Etorphine; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri; Taste | 1982 |
Peptide and non-peptide opioid-induced hyperthermia in rabbits.
Topics: Animals; beta-Endorphin; Body Temperature; Cyclazocine; Endorphins; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; Male; Morphine; Naloxone; Peptides; Phenazocine; Rats | 1983 |
Visualization and solubilization of rat brain opiate receptors with a "kappa" ligand selectivity pattern.
Topics: Animals; Binding, Competitive; Corpus Striatum; Cyclazocine; Ethylketocyclazocine; Rats; Receptors, Opioid; Solubility; Structure-Activity Relationship | 1982 |
[3H]Mr 2034 labels a high affinity opioid kappa-receptor not accessible to naloxazone.
Topics: Animals; Benzomorphans; Binding, Competitive; Brain; Cyclazocine; Ethylketocyclazocine; In Vitro Techniques; Kinetics; Morphinans; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1983 |
Differential stereospecific effects of mu, kappa, and sigma opioid agonists on cortical EEG power spectra in the rat.
Topics: Animals; Cerebral Cortex; Cyclazocine; Electroencephalography; Ethylketocyclazocine; Female; Methadone; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma; Stereoisomerism | 1983 |
Effectiveness of ethylketocyclazocine in hemorrhagic shock.
Topics: Animals; Blood Pressure; Cathepsin D; Cathepsins; Cats; Cyclazocine; Ethylketocyclazocine; Male; Myocardial Depressant Factor; Receptors, Opioid; Shock, Hemorrhagic | 1983 |
Opiate-induced enhancement of the effects of naloxone on serum luteinizing hormone levels in the male rat: specificity for Mu agonists.
Topics: Animals; Binding, Competitive; Cyclazocine; Ethanol; Ethylketocyclazocine; Kinetics; Luteinizing Hormone; Male; Morphine; Naloxone; Pentobarbital; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid | 1983 |
The binding to rat brain homogenates of Mr2034, a universal opiate.
Topics: Animals; Benzomorphans; Brain; Cyclazocine; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Male; Morphinans; Naloxone; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid | 1983 |
An analysis of nicotinic and opioid processes in the medulla oblongata and nucleus ambiguus of the dog.
Topics: Animals; Blood Pressure; Cyclazocine; Decerebrate State; Dogs; Electric Stimulation; Endorphins; Ethylketocyclazocine; Female; Fentanyl; Heart Rate; Male; Mecamylamine; Medulla Oblongata; Naloxone; Nicotine; Phenazocine; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma | 1983 |
Naloxone-inaccessible sigma receptor in rat central nervous system.
Topics: Animals; Binding, Competitive; Brain; Cyclazocine; Enkephalins; Ethylketocyclazocine; Kinetics; Naloxone; Phenazocine; Phencyclidine; Rats; Receptors, Opioid; Receptors, sigma; Spinal Cord; Tissue Distribution | 1983 |
The effect of the opioid-benzodiazepine, tifluadom, on ingestive behaviors.
Topics: Animals; Benzodiazepines; Butorphanol; Cyclazocine; Drinking Behavior; Ethylketocyclazocine; Feeding Behavior; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1983 |
Opiate binding sites in bovine adrenal medulla.
Topics: Adrenal Medulla; Animals; Binding Sites; Brain; Brain Chemistry; Cattle; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; In Vitro Techniques; Ligands; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1983 |
Characterization of solubilized opiate receptors from human placenta.
Topics: Binding, Competitive; Chemical Phenomena; Chemistry, Physical; Cyclazocine; Ethylketocyclazocine; Etorphine; Female; Humans; Naloxone; Placenta; Pregnancy; Receptors, Opioid; Solubility | 1983 |
N-allylnormetazocine (SKF-10,047): the induction of feeding by a putative sigma agonist.
Topics: Animals; Cyclazocine; Dose-Response Relationship, Drug; Drug Interactions; Eating; Ethylketocyclazocine; Male; Morphine; Naloxone; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid | 1983 |
Effects of mu- and kappa-opioid receptor agonists on urinary output in mice.
Topics: Animals; Benzomorphans; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Fentanyl; Male; Mice; Morphine; Naloxone; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Species Specificity; Stimulation, Chemical; Urination | 1983 |
Determination of receptors that mediate opiate side effects in the mouse.
Topics: Analgesics; Animals; Benzamides; Benzomorphans; Body Temperature; Cyclazocine; Ethylketocyclazocine; Female; Gastrointestinal Motility; Male; Mice; Narcotic Antagonists; Narcotics; Pentazocine; Pupil; Receptors, Opioid; Respiration; Rotation; Tail | 1983 |
Discriminative stimulus properties of nalorphine in the rhesus monkeys.
Topics: Animals; Benzodiazepines; Benzomorphans; Conditioning, Operant; Cyclazocine; Discrimination Learning; Dose-Response Relationship, Drug; Ethylketocyclazocine; Macaca mulatta; Male; Nalorphine; Naloxone; Phenazocine; Receptors, Opioid; Receptors, Opioid, kappa | 1983 |
Prenatal and postnatal exposure to diazepam: effects on opioid receptor binding in rat brain cortex.
Topics: Animals; Cerebral Cortex; Corpus Striatum; Cyclazocine; Diazepam; Ethylketocyclazocine; Female; Male; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Receptors, Opioid | 1983 |
Central cardiovascular effects of kappa agonists dynorphin-(1-13) and ethylketocyclazocine in the anaesthetized rat.
Topics: Animals; beta-Endorphin; Blood Pressure; Cyclazocine; Dynorphins; Endorphins; Enkephalin, Methionine; Ethylketocyclazocine; Fentanyl; Heart Rate; Male; Naloxone; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Vagus Nerve | 1983 |
Comparison of mu, delta, and kappa opiate binding sites in rat brain and spinal cord.
Topics: Animals; Binding Sites; Brain; Cell Membrane; Cyclazocine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord | 1984 |
The kappa opioid receptor, ingestive behaviors and the obese mouse (ob/ob).
Topics: Animals; Appetite; Benzodiazepines; Body Weight; Butorphanol; Cyclazocine; Dose-Response Relationship, Drug; Drinking; Eating; Ethylketocyclazocine; Male; Mice; Mice, Obese; Receptors, Opioid; Receptors, Opioid, kappa | 1983 |
Identification of benzomorphan-kappa opiate receptors in cerebral arteries which subserve relaxation.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Cerebral Arteries; Cyclazocine; Dinoprost; Dogs; Drug Interactions; Ethylketocyclazocine; Female; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Phencyclidine; Prostaglandins F; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa | 1984 |
Differential tolerance and cross-tolerance to repeated daily injections of mu and kappa opioid agonists in the rat.
Topics: Animals; Behavior, Animal; Cyclazocine; Drug Tolerance; Electroencephalography; Electromyography; Ethylketocyclazocine; Male; Morphine; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sleep, REM | 1984 |
Similar anticonvulsant, but unique, behavioural effects of opioid agonists in the seizure-sensitive Mongolian gerbil.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cyclazocine; Electroencephalography; Ethylketocyclazocine; Female; Gerbillinae; Male; Morphine; Narcotics; Phenazocine; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Seizures | 1984 |
Further characterization of the three-choice morphine, cyclazocine and saline discrimination paradigm: opioids with agonist and antagonist properties.
Topics: Animals; Cyclazocine; Discrimination Learning; Discrimination, Psychological; Ethylketocyclazocine; Male; Morphine; Narcotic Antagonists; Narcotics; Phenazocine; Phencyclidine; Rats; Sodium Chloride; Stereoisomerism | 1983 |
Ketazocines and morphine: effects on gastrointestinal transit after central and peripheral administration.
Topics: Animals; Cyclazocine; Ethylketocyclazocine; Gastrointestinal Motility; Injections, Intraventricular; Injections, Subcutaneous; Male; Morphine; Phenazocine; Rats; Rats, Inbred Strains | 1983 |
[3H]ethylketocyclazocine binding to NCB-20 hybrid neurotumor cells.
Topics: Animals; Binding, Competitive; Brain; Cricetinae; Cricetulus; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Hybrid Cells; Kinetics; Neuroblastoma; Trypsin | 1983 |
Effects of opiate agonists on the conditioned suppression in motility of mice.
Topics: Animals; Conditioning, Psychological; Cyclazocine; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Ethylketocyclazocine; Male; Mice; Morphine; Motor Activity; Phencyclidine | 1983 |
Adrenal modulation of opiate induced feeding.
Topics: Adrenal Glands; Adrenalectomy; Animals; Butorphanol; Corticosterone; Cyclazocine; Endorphins; Ethylketocyclazocine; Feeding Behavior; Male; Naloxone; Rats; Rats, Inbred Strains | 1983 |
Self-administration of ketocyclazocine and ethylketocyclazocine by the rat.
Topics: Animals; Cyclazocine; Drug Tolerance; Electroencephalography; Ethylketocyclazocine; Female; Humans; Injections, Intravenous; Opioid-Related Disorders; Rats; Rats, Inbred Strains; Self Administration | 1983 |
A comparison of the effects of corticotropin releasing factor and sauvagine on food intake.
Topics: Amphibian Proteins; Animals; Corticotropin-Releasing Hormone; Cyclazocine; Ethylketocyclazocine; Feeding Behavior; Food Deprivation; Male; Peptide Hormones; Peptides; Rats; Rats, Inbred Strains | 1983 |
Effects of ketocyclazocine and ethylketocyclazocine on electric shock titration.
Topics: Animals; Behavior, Animal; Cyclazocine; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Electroshock; Ethylketocyclazocine; Morphine; Naloxone; Saimiri | 1983 |
Opposite central cardiovascular effects of various morphine-like drugs and opiate peptides in the rat.
Topics: Animals; Blood Pressure; Brain; Cyclazocine; Dynorphins; Endorphins; Enkephalin, Methionine; Ethylketocyclazocine; Fentanyl; Heart Rate; Male; Peptide Fragments; Rats; Rats, Inbred Strains | 1983 |
Phencyclidine-induced inhibition of striatal acetylcholine release: comparisons with mu, kappa, and sigma opiate agonists.
Topics: Acetylcholine; Animals; Corpus Striatum; Cyclazocine; Ethylketocyclazocine; Haloperidol; Male; Morphine; Naloxone; Narcotic Antagonists; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains | 1984 |
Analgesia induced by intrathecal injection of dynorphin B in the rat.
Topics: Analgesics; Animals; Cyclazocine; Dose-Response Relationship, Drug; Drug Tolerance; Dynorphins; Endorphins; Enkephalin, Leucine; Ethylketocyclazocine; Female; Injections, Spinal; Morphine; Naloxone; Rats | 1984 |
Effects of opioids on accuracy of a fixed-ratio discrimination in monkeys and rats.
Topics: Animals; Buprenorphine; Cyclazocine; Discrimination Learning; Dose-Response Relationship, Drug; Erythrocebus patas; Ethylketocyclazocine; Isomerism; Macaca mulatta; Male; Methadone; Morphinans; Morphine; Phenazocine; Rats | 1984 |
Narcotic discrimination in pigeons: antagonism by naltrexone.
Topics: Animals; Columbidae; Cyclazocine; Discrimination, Psychological; Dose-Response Relationship, Drug; Ethylketocyclazocine; Meperidine; Morphine; Naloxone; Naltrexone; Narcotics | 1984 |
Stimulation of food intake following opiate agonists in rats but not hamsters.
Topics: Animals; Cricetinae; Cyclazocine; Dose-Response Relationship, Drug; Drinking Behavior; Ethylketocyclazocine; Feeding Behavior; Male; Meperidine; Mesocricetus; Morphine; Narcotics; Rats; Rats, Inbred Strains; Species Specificity | 1983 |
Analgesic effects of ethylketocyclazocine and morphine in rat and toad.
Topics: Analgesia; Animals; Brain; Bufo marinus; Cyclazocine; Dose-Response Relationship, Drug; Electroshock; Ethylketocyclazocine; Male; Morphine; Motor Activity; Naloxone; Rats; Rats, Inbred Strains | 1984 |
Behavioral interactions of opioid agonists and antagonists with serotonergic systems.
Topics: Animals; Brain; Conditioning, Operant; Cyclazocine; DOM 2,5-Dimethoxy-4-Methylamphetamine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Lysergic Acid Diethylamide; Male; Metergoline; Naloxone; Narcotic Antagonists; Narcotics; Phenazocine; Quipazine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Reinforcement Schedule | 1984 |
Progress report from the NIDA Addiction Research Center Baltimore, Maryland (1984).
Topics: Blood Pressure; Body Temperature; Compulsive Behavior; Cyclazocine; Discrimination Learning; Endorphins; Ethylketocyclazocine; Euphoria; Gambling; Glucose; Heart Rate; Humans; Morphine; Naloxone; Nicotine; Perception; Respiration; Substance-Related Disorders; Time Factors | 1984 |
Modification of an analgesy meter for paw-pressure antinociceptive testing in neonatal rats.
Topics: Aging; Analgesics; Animals; Animals, Newborn; Cyclazocine; Drug Evaluation, Preclinical; Ethylketocyclazocine; Foot; Pressure; Rats; Tail | 1984 |
Development of enhanced sensitivity to naloxone.
Topics: Animals; Buprenorphine; Cyclazocine; Diprenorphine; Dose-Response Relationship, Drug; Drug Interactions; Ethylketocyclazocine; Male; Meperidine; Naloxone; Phencyclidine; Reaction Time; Saimiri | 1983 |
Catatonic or hypotonic immobility induced in mice by intracerebroventricular injection of mu or kappa opioid receptor agonists as well as enkephalins or inhibitors of their degradation.
Topics: Animals; Benzomorphans; Catatonia; Cyclazocine; Enkephalins; Ethylketocyclazocine; Fentanyl; Humans; Immobilization; Injections, Intraventricular; Male; Mice; Morphine; Naloxone; Narcotic Antagonists; Narcotics | 1983 |
Agonist and antagonist effects of prototype opiate drugs in rats discriminating fentanyl from saline: characteristics of partial generalization.
Topics: Animals; Conditioning, Operant; Cyclazocine; Discrimination Learning; Ethylketocyclazocine; Fentanyl; Male; Morphine; Nalorphine; Naloxone; Narcotics; Phenazocine; Rats; Rats, Inbred Strains; Sodium Chloride | 1984 |
Phencyclidine-like discriminative stimulus properties of psychotomimetic opioids.
Topics: Animals; Columbidae; Cyclazocine; Discrimination, Psychological; Ethylketocyclazocine; Generalization, Psychological; Generalization, Stimulus; Morphine; Naltrexone; Phencyclidine; Rats; Saimiri | 1982 |
Hippocampal involvement in the pharmacologic induction of withdrawal-like behaviors.
Topics: Animals; Cyclazocine; Endorphins; Enkephalin, Methionine; Enkephalins; Escape Reaction; Ethylketocyclazocine; Hippocampus; Humans; Injections, Intraventricular; Kainic Acid; Morphine Dependence; Pyrrolidines; Rats; Serotonin; Shivering; Substance Withdrawal Syndrome; Valproic Acid | 1981 |
Pharmacologic effects of N-allylnormetazocine (SKF-10047).
Topics: Analgesics; Animals; Behavior, Animal; Clonidine; Cyclazocine; Ethylketocyclazocine; Male; Morphine; Motor Activity; Phenazocine; Rats; Receptors, Dopamine; Spiperone | 1981 |
Discriminative stimulus effects of etorphine in Rhesus monkeys.
Topics: Animals; Codeine; Cyclazocine; Discrimination Learning; Ethylketocyclazocine; Etorphine; Macaca mulatta; Male; Meperidine; Morphinans; Morphine; Pentazocine; Phenazocine; Sodium Chloride | 1981 |
Increased food and water intake produced in rats by opiate receptor agonists.
Topics: Animals; Cyclazocine; Drinking; Drug Interactions; Eating; Enkephalins; Ethylketocyclazocine; Male; Morphine; Naloxone; Narcotics; Rats | 1981 |
Effects of ketocyclazocine alone and in combination with naloxone on schedule-controlled responding in squirrel monkeys.
Topics: Animals; Conditioning, Operant; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Male; Naloxone; Reinforcement Schedule; Saimiri | 1983 |
Differential effects of prototype opioid agonists on the acquisition of conditional discriminations in monkeys.
Topics: Animals; Behavior, Animal; Conditioning, Psychological; Cyclazocine; Discrimination Learning; Dose-Response Relationship, Drug; Erythrocebus patas; Ethylketocyclazocine; Male; Morphine; Pentazocine; Phenazocine; Psychomotor Performance | 1983 |
Narcotic discrimination in pigeons.
Topics: Animals; Clonidine; Codeine; Columbidae; Cyclazocine; Discrimination Learning; Dose-Response Relationship, Drug; Ethylketocyclazocine; Ketamine; Meperidine; Morphine; Nalorphine; Naltrexone; Narcotics; Pentazocine; Pentobarbital; Species Specificity | 1980 |
High affinity binding of [3H]ethylketocyclazocine to rat brain homogenate.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Cyclazocine; Ethylketocyclazocine; Kinetics; Male; Narcotics; Rats; Receptors, Drug | 1980 |
Pharmacological analysis of the discriminative stimulus characteristics of ethylketazocine in the rhesus monkey.
Topics: Animals; Cyclazocine; Dextrorphan; Dose-Response Relationship, Drug; Ethylketocyclazocine; Ketamine; Macaca mulatta; Naltrexone; Narcotic Antagonists; Narcotics; Phencyclidine; Prejudice; Stereoisomerism | 1981 |
Classification of narcotics on the basis of their reinforcing, discriminative, and antagonist effects in rhesus monkeys.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Cyclazocine; Discrimination, Psychological; Ethylketocyclazocine; Humans; Macaca; Macaca mulatta; Morphine; Naloxone; Naltrexone; Narcotics; Opioid-Related Disorders; Reinforcement, Psychology; Self Administration | 1982 |
Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. 4. Opioid receptor binding properties of 8-[N-(4'-phenyl)-phenethyl)carboxamido] analogues of cyclazocine and ethylketocycalzocine.
Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Cyclazocine; Ethylketocyclazocine; Humans; Hydrophobic and Hydrophilic Interactions; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereoisomerism; Structure-Activity Relationship | 2006 |